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https://www.readbyqxmd.com/read/28236118/expression-of-vista-correlated-with-immunosuppression-and-synergized-with-cd8-to-predict-survival-in-human-oral-squamous-cell-carcinoma
#1
Lei Wu, Wei-Wei Deng, Cong-Fa Huang, Lin-Lin Bu, Guang-Tao Yu, Liang Mao, Wen-Feng Zhang, Bing Liu, Zhi-Jun Sun
V-domain Ig suppressor of T cell activation (VISTA), a novel immune checkpoint regulatory molecule, suppresses T cell mediated immune responses. The aim of the present study was to profile the immunological expression, clinical significance and correlation of VISTA in human oral squamous cell carcinoma (OSCC). Human tissue microarrays, containing 165 primary OSCCs, 48 oral epithelial dysplasias and 43 normal oral mucosae, were applied to investigate the expression levels of VISTA, CD8, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed death ligand 1 (PD-L1), PI3Kα p110, IL13Rα2, phospho-STAT3 at tyrosine 705 (p-STAT3) and myeloid-derived suppressor cell (MDSC) markers (CD11b and CD33) by immunohistochemistry and digital pathology analysis...
February 24, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28223834/bile-salt-receptor-tgr5-is-highly-expressed-in-esophageal-adenocarcinoma-and-precancerous-lesions-with-significantly-worse-overall-survival-and-gender-differences
#2
Chunhong Pang, Amy LaLonde, Tony E Godfrey, Jianwen Que, Jun Sun, Tong Tong Wu, Zhongren Zhou
Bile acid reflux in the esophagus plays an important role in the carcinogenesis of esophageal adenocarcinoma (EAC). The G-protein coupled bile acid receptor (TGR5) has been associated with the development of gastrointestinal cancer. However, little is known regarding the role of TGR5 in esophageal carcinoma and precancerous lesions. We analyzed genomic DNA from 116 EACs for copy number aberrations via Affymetrix SNP6.0 microarrays. The TGR5 gene locus was amplified in 12.7% (14/116) of the EACs. The TGR5 protein expression was also assessed using immunohistochemistry from tissue microarrays, including Barrett's esophagus (BE), low-(LGD) and high-grade dysplasia (HGD), columnar cell metaplasia (CM), squamous epithelium (SE), EAC and squamous cell carcinoma...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28214204/detection-of-occult-endocervical-glandular-dysplasia-in-cervical-conization-specimens-for-squamous-lesions
#3
F Sopracordevole, N Clemente, L Alessandrini, J Di Giuseppe, F Cigolot, M Buttignol, A Ciavattini, V Canzonieri
The aim of this work was to evaluate the incidence of occult cervical glandular intraepithelial neoplasia (CGIN) and adenocarcinoma of the cervix (AC) in women treated with CO2-laser conization for cervical intraepithelial neoplasia (CIN) or squamocellular cervical cancer (SCC). The medical records of all women with a histological diagnosis of squamous lesions of the uterine cervix (persistent CIN1, CIN2, CIN3 and SCC) who were subsequently treated with CO2-laser conization at our institution, during the period from January 1991 to December 2014, were analyzed in a retrospective case series...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28212604/high-expression-of-claudin-2-in-esophageal-carcinoma-and-precancerous-lesions-is-significantly-associated-with-the-bile-salt-receptors-vdr-and-tgr5
#4
Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun, Zhongren Zhou
BACKGROUND: Claudins are a family of integral membrane proteins and are components of tight junctions (TJs). Many TJ proteins are known to tighten the cell structure and maintain a barrier. Claudin-2 forms gated paracellular channels and allows sodium ions and other small positively charged ions to cross between adjacent cells. Recently, we found that vitamin D receptor (VDR) enhanced Claudin-2 expression in colon and that bile salt receptors VDR and Takeda G-protein coupled receptor5 (TGR5) were highly expressed in esophageal adenocarcinoma (EAC) and precancerous lesions...
February 17, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28209524/foxa1-in-hpv-associated-carcinomas-its-expression-in-carcinomas-of-the-head-and-neck-and-of-the-uterine-cervix
#5
Georgia Karpathiou, Vanessa Da Cruz, Francois Casteillo, Mousa Mobarki, Jean Marc Dumollard, Celine Chauleur, Fabien Forest, Jean Michel Prades, Michel Peoc'h
BACKGROUND: FOXA1 is a major transcription factor involved in the action of human papilloma virus (HPV). However, it has been never studied in HPV-associated tumors. AIM OF THE STUDY: To investigate its expression in cervical and head and neck tumors. MATERIAL AND METHODS: 63 cervical carcinomas/dysplasias and 152 head and neck squamous cell carcinomas (HNSCC) were immunohistochemically studied for the expression of FOXA1. RESULTS: 63...
February 14, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28199128/sox2-drives-bronchial-dysplasia-in-a-novel-organotypic-model-of-early-human-squamous-lung-cancer
#6
Lúcia L Correia, Jo-Anne Johnson, Peter McErlean, Julien Bauer, Hassan Farah, Doris M Rassl, Robert C Rintoul, Tariq Sethi, Paul Lavender, Emma L Rawlins, Trevor D Littlewood, Gerard I Evan, Frank M McCaughan
Rationale Improving the early detection and chemoprevention of lung cancer are key to improving outcomes. The pathobiology of early squamous lung cancer is poorly understood. We have shown that amplification of SOX2 is an early and consistent event in the pathogenesis of this disease but its functional oncogenic potential remains uncertain. We tested the impact of deregulated SOX2 expression in a novel organotypic system that recreates the molecular and microenvironmental context in which squamous carcinogenesis occurs...
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28181187/transcriptionally-active-high-risk-human-papillomavirus-is-not-a-common-etiologic-agent-in-the-malignant-transformation-of-inverted-schneiderian-papillomas
#7
Lisa M Rooper, Justin A Bishop, William H Westra
The role of human papillomavirus (HPV) as an etiologic and transformational agent in inverted Schneiderian papilloma (ISP) is unclear. Indeed, reported detection rates of HPV in ISPs range from 0 to 100%. The true incidence has been confounded by a tendency to conflate high- and low-risk HPV types and by the inability to discern biologically relevant from irrelevant HPV infections. The recent development of RNA in situ hybridization for high-risk HPV E6/E7 mRNA now allows the direct visualization of transcriptionally active high-risk HPV in ISP, providing an opportunity to more definitively assess its role in the development and progression of ISPs...
February 8, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28162852/the-role-of-immunosuppression-in-squamous-cell-carcinomas-arising-in-seborrheic-keratosis
#8
Ruzica Z Conic, Karl Napekoski, Heidi Schuetz, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
BACKGROUND: Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described. OBJECTIVE: To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions. METHODS: There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic specimens and medical records were reviewed...
February 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28160592/development-of-proliferative-verrucous-leukoplakia-pvl-in-oral-lichen-planus-is-it-not-a-clinical-spectrum-of-pvl
#9
D-T Fernandes, A-R Santos-Silva, P-A Vargas, M-A Lopes
In their recent publication, Garcia-Pola et al. (2016) suggested the development of proliferative verrucous leukoplakia (PVL) in oral lichen planus (OLP). It was described as a preliminary study, where this association supposedly occurred (1). They presented a retrospective analysis with a long-term follow-up, showing an interesting relationship between these lesions. It is important to emphasize that the clinical profile of patients with PVL is well recognized in the literature, mainly affecting non-smoking and non-drinking elderly women, older than 60 years (2-4)...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28160456/primary-anorectal-mucosal-melanoma-detected-by-anorectal-cytology
#10
Ryan Paul Lau, Jeanine Chiaffarano, Melissa Alexander, Jolene Octavius, Omar Azar, Yan Shi, Melissa Yee-Chang
The detection of primary anorectal melanoma on anal cytology is a rare and challenging diagnosis. We report a case where anorectal cytology showed isolated malignant cells with oval nuclei, prominent nucleoli, and elongated wispy cytoplasmic projections. There was no evidence of squamous dysplasia or melanin pigment identified. To the best of our knowledge, this is the first reported case of a primary anorectal melanoma detected in anorectal cytology. Detection of malignancies other than squamous cell carcinoma can be seen on anorectal cytology and should be considered when there is no evidence of anal intraepithelial neoplasia...
February 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28153131/laryngeal-dysplasia-squamous-cell-carcinoma-and-variants
#11
REVIEW
Lester D R Thompson
Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Each SCC variant has unique cytomorphologic features and histologic differential diagnoses that are important to consider, as management and outcomes are different...
March 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28150409/bizarre-cell-dysplasia-of-the-cervix
#12
Ondrej Ondič, Radoslav Ferko, Jana Kašpírková, Marián Švajdler, Boris Rýchly, Peter Talarčík, Jiří Bouda, Michal Michal
AIM: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD). METHODS: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. BCD was defined as a subtype of HSIL characterized by the presence of large dysplastic cells with abnormal, large pleomorphic nuclei or multinucleation causing nucleomegaly...
February 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28146434/selective-extracellular-vesicle-exclusion-of-mir-142-3p-by-oral-cancer-cells-promotes-both-internal-and-extracellular-malignant-phenotypes
#13
Christopher Td Dickman, James Lawson, James Jabalee, Sara A MacLellan, Nancy E LePard, Kevin L Bennewith, Cathie Garnis
Packaging of small molecular factors, including miRNAs, into small extracellular vesicles (SEVs) may contribute to malignant phenotypes and facilitate communication between cancer cells and tumor stroma. The process by which some miRNAs are enclosed in SEVs is selective rather than indiscriminate, with selection in part governed by specific miRNA sequences. Herein, we describe the selective packaging and removal via SEVs of four miRNAs (miR-142-3p, miR-150-5p, miR-451a, and miR-223-3p) in a panel of oral dysplasia and oral squamous cell carcinoma cell lines...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28141783/prevalence-of-anal-hpv-and-anal-dysplasia-in-hiv-infected-women-from-johannesburg-south-africa
#14
Bridgette J Goeieman, Cynthia S Firnhaber, Eefje Jong, Pam Michelow, Avril Swarts, Anna-Lise Williamson, Bruce Allan, Jennifer S Smith, Patricia Kegorilwe, Timothy J Wilkin
BACKGROUND: Anal cancer is a relatively common cancer among HIV-infected populations. There are limited data on the prevalence of anal high-risk human papillomavirus (HR-HPV) infection and anal dysplasia in HIV-infected women from resource-constrained settings. METHODS: A cross-sectional study of HIV-infected women age 25-65 recruited from an HIV clinic in Johannesburg, South Africa. Cervical and anal swabs were taken for conventional cytology and HR-HPV testing...
January 30, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28129293/ocular-surface-epithelial-atypia-mimicking-squamous-neoplasia-in-association-with-ulcerative-colitis
#15
Sally S Ong, Scott D Walter, Xi Chen, Gargi K Vora, Melissa Daluvoy, Alan D Proia, Prithvi Mruthyunjaya
PURPOSE: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). METHODS: Case report. RESULTS: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28123440/biliary-intraepithelial-neoplasia-bilin-in-primary-sclerosing-cholangitis-the-first-report-from-iran
#16
Laleh Akbarzadeh, Bita Geramizadeh, Kurosh Kazemi, Saman Nikeghbalian, Seyedali Malekhosseini
BACKGROUND: Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to cholangiocarcinoma. There are very few studies about the frequency of BilIN in the patients with PSC and its correlation with paraclinical findings. OBJECTIVES: In this study, we tried to find the frequency of BilIN in the patients with PSC and correlate its presence with clinicopathologic factors...
December 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/28116435/-expression-of-cytokeratin-19-in-the-development-and-progression-of-oral-squamous-cell-carcinoma
#17
Dan Tan, Chun-Hui Li, Min-Hai Nie
PURPOSE: To investigate the expression of cytokeratin 19 (CK19) in various stages of oral squamous cell carcinoma (OSCC), and to explore the relation between CK19 and OSCC. METHODS: Forty-nine specimens including normal oral mucosa, epithelial hyperplasia, epithelial dysplasia, and oral squamous carcinoma were investigated. The expression of CK19 was detected by immunohistochemistry and Western blot. The serum of OSCC patients and healthy people was collected and CYFRA21-1 level was determined by ELISA...
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28116194/endocervical-carcinogenesis-and-hpv-vaccination-an-occasional-circumstance-or-a-gap-in-the-chain
#18
Georgios-Marios Makris, Petros Karakitsos, Eugenia Kotsifa, Niki Margari, Nikiforita Poulakaki, Theodoros N Sergentanis, Marco-Johannes Battista, Charalampos Chrelias, Nicolaos Papantoniou
As a result of the Human Papillomavirus (HPV) vaccination program, the prevalence of precancerous dysplasia and invasive cervical cancer has substantially decreased. In this brief report, we present a case of a young patient who was diagnosed with in situ adenocarcinoma of the cervix. This 30-year-old female had completed the HPV vaccination after she became sexually active and has been undergoing annual gynecological assessments, including clinical examination and Pap test, all of which had been negative. This year, her Pap test revealed a low grade squamous intraepithelial lesion (LGSIL) and additionally a colposcopy was performed...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28110942/individualized-five-year-risk-assessment-for-oral-premalignant-lesion-progression-to-cancer
#19
Jason T K Hwang, Ying R Gu, Mi Shen, Ranju Ralhan, Paul G Walfish, Kenneth P H Pritzker, David Mock
OBJECTIVE: The standard of care for premalignant lesion risk assessment is dysplasia grading by histopathology. With significant overlap between dysplasia grades and high inter- and intraobserver variations, histopathology dysplasia grading alone is not a useful prognostic tool. Our aim is to investigate whether a method for quantitatively assessing S100A7, a prognostic biomarker, using image analysis can better predict clinical outcome in cases with oral dysplasia. STUDY DESIGN: Using the Visiopharm image analysis system, we analyzed a cohort of 150 oral biopsy samples to build and test Straticyte, a model for individualized assessment of the 5-year risk of progression of oral precancerous lesions to invasive squamous cell carcinomas...
March 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28094216/mild-to-moderate-dysplasia-at-surgical-margin-is-a-significant-indicator-of-survival-in-patients-with-oral-cancer
#20
Sandhya Gokavarapu, Nagendra Parvataneni, Sreenivasa Pavagada, L M Chandrasekhara Rao, K V Raju, T Subramaneshwar Rao
OBJECTIVE: The objective of this study was to investigate the significance of mild and moderate dysplasia at the surgical margin with regard to survival and locoregional recurrence. STUDY DESIGN: We investigated cases of primary oral squamous cell carcinoma with negative margins retrospectively from the database of a tertiary cancer hospital. All patients had been treated between January 2010 and December 2012, and margin dysplasia was investigated in a multivariate analysis for locoregional recurrence and overall survival...
March 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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