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https://www.readbyqxmd.com/read/28811703/barrett-s-oesophagus-current-controversies
#1
REVIEW
Chidi Amadi, Piers Gatenby
Oesophageal adenocarcinoma is rapidly increasing in Western countries. This tumour frequently presents late in its course with metastatic disease and has a very poor prognosis. Barrett's oesophagus is an acquired condition whereby the native squamous mucosa of the lower oesophagus is replaced by columnar epithelium following prolonged gastro-oesophageal reflux and is the recognised precursor lesion for oesophageal adenocarcinoma. There are multiple national and society guidelines regarding screening, surveillance and management of Barrett's oesophagus, however all are limited regarding a clear evidence base for a well-demonstrated benefit and cost-effectiveness of surveillance, and robust risk stratification for patients to best use resources...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28807115/correlation-between-hpv-status-via-in-situ-hybridization-testing-on-genital-squamous-papillomas-and-risk-for-cervical-dysplasia-or-other-anogenital-hpv-related-complications-a-case-control-study
#2
Michelle J Duvall, Julie A Maxon, Julia S Lehman
No abstract text is available yet for this article.
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28799537/hpv-16-in-a-distinct-subset-of-oral-epithelial-dysplasia
#3
Mark A Lerman, Soulafa Almazrooa, Neal Lindeman, Dimity Hall, Alessandro Villa, Sook-Bin Woo
Human papillomavirus (HPV) 16 is the most common high-risk HPV type identified in oropharyngeal and cervical neoplasia. Recently, HPV-associated oral epithelial dysplasia with specific histopathologic features and demographics similar to HPV-oropharyngeal carcinoma has been identified. The objective of this study was to evaluate histopathologically all cases of HPV-oral epithelial dysplasia seen in one center and identify HPV types in a subset of cases. Cases with specific histopathology for HPV-oral epithelial dysplasia that were positive both by immunohistochemical studies for p16 and by in situ hybridization for high-risk types of HPV were further analyzed using QIAamp DNA Tissue Kits (Qiagen, Hilden, Germany)...
August 11, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28797449/nomogram-for-risk-prediction-of-malignant-transformation-in-oral-leukoplakia-patients-using-combined-biomarkers
#4
Xianglan Zhang, Ki-Yeol Kim, Zhenlong Zheng, Shadavlonjid Bazarsad, Jin Kim
OBJECTIVE: Squamous cell carcinomas (SCC) are the most common malignancies in the oral mucosa; these carcinomas have been preceded by potentially malignant oral disorders (PMODs), mostly oral leukoplakia (OL). No specific biomarker has been widely accepted for predicting the risk of malignant transformation of PMODs. The aim of this study was to develop an accurate prediction model for the malignant transformation of OL using clinical variables and candidate biomarkers. MATERIALS AND METHODS: To achieve this goal, 10 candidate biomarkers that had previously been reported as useful molecules were investigated: P53, Ki-67, P16, β-catenin, c-jun, c-met, insulin like growth factor II mRNA-binding protein (IMP-3), cyclooxygenase (COX-2), podoplanin (PDPN) and carbonic anhydrase 9 (CA9)...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797444/straticyte-demonstrates-prognostic-value-over-oral-epithelial-dysplasia-grade-for-oral-potentially-malignant-lesion-assessment
#5
Jason T K Hwang, Ying R Gu, Benjamin J Dickson, Mi Shen, Ranju Ralhan, Paul G Walfish, David Mock, Kenneth P H Pritzker
OBJECTIVES: Straticyte™ was previously shown to be a more effective prognostic assessment than the current standard of care, histopathological dysplasia grading, to assess progression risk of oral epithelial dysplasia to invasive cancer [Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123:374-81]. In this follow-up study, our aim is to confirm the prognostic value of Straticyte using an independent cohort of oral biopsy cases previously assessed as epithelial dysplasia of various grades...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28791328/a-feasibility-study-of-photoacoustic-imaging-of-ex-vivo-endoscopic-mucosal-resection-tissues-from-barrett-s-esophagus-patients
#6
Liang Lim, Catherine J Streutker, Norman Marcon, Maria Cirocco, Alexandra Lao, Vladimir V Iakovlev, Ralph DaCosta, Brian C Wilson
BACKGROUND AND STUDY AIMS : Accurate endoscopic detection of dysplasia in patients with Barrett's esophagus (BE) remains a major clinical challenge. The current standard is to take multiple biopsies under endoscopic image guidance, but this leaves the majority of the tissue unsampled, leading to significant risk of missing dysplasia. Furthermore, determining whether there is submucosal invasion is essential for proper staging. Hence, there is a clinical need for a rapid in vivo wide-field imaging method to identify dysplasia in BE, with the capability of imaging beyond the mucosal layer...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28781790/somatic-brca1-associated-protein-1-bap1-loss-is-an-early-and-rare-event-in-esophageal-adenocarcinoma
#7
Heike Loeser, Dirk Waldschmidt, Fabian Kuetting, Simon Schallenberg, Thomas Zander, Elfriede Bollschweiler, Arnulf Hoelscher, Katharina Weckermann, Patrick Plum, Hakan Alakus, Reinhard Buettner, Alexander Quaas
Esophageal cancer is the eighth most common malignant tumor worldwide, and the number of incidences of esophageal adenocarcinoma is increasing in the Western world. Despite improvements in perioperative treatment, the overall survival rate of patients with esophageal adenocarcinoma remains poor. Breast cancer type 1 susceptibility protein (BRCA1)-associated protein (BAP1) is located on chromosome 3p21, and it is an enzyme with ubiquitin carboxyl hydrolase activity that regulates cell growth. It interacts with BRCA1, and the nuclear localization of BAP1 is required for its tumor suppressor function...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28766760/the-methylation-status-and-expression-of-human-telomerase-reverse-transcriptase-is-significantly-high-in-oral-carcinogenesis
#8
Kazuya Haraguchi, Naomi Yada, Shinobu Sato, Manabu Habu, Mana Hayakawa, Osamu Takahashi, Masaaki Sasaguri, Shigeori Takenaka, Izumi Yoshioka, Kou Matsuo, Kazuhiro Tominaga
Telomerase activity is present in most cancers and is tightly regulated by the expression of human telomerase reverse transcriptase (hTERT). Hypermethylation in the promoter region of hTERT contributes to the regulation of hTERT expression. In this study, we investigated the methylation and expression of hTERT in oral squamous cell carcinoma (OSCC), oral leukoplakia, and normal oral mucosa. Furthermore, we investigated the significance of hTERT to the clinicopathological findings of OSCC. 35 OSCC, 50 oral leukoplakia (epithelial dysplasia n = 25, squamous cell hyperplasia n = 25), and 10 normal oral mucosa samples were investigated through methylation-specific PCR...
September 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#9
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. 815 incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28752518/the-color-of-cancer-margin-guidance-for-oral-cancer-resection-using-elastic-scattering-spectroscopy
#10
Gregory A Grillone, Zimmern Wang, Gintas P Krisciunas, Angela C Tsai, Vishnu R Kannabiran, Robert W Pistey, Qing Zhao, Eladio Rodriguez-Diaz, Ousama M A'Amar, Irving J Bigio
OBJECTIVES/HYPOTHESIS: To evaluate the usefulness of elastic scattering spectroscopy (ESS) as a diagnostic adjunct to frozen section analysis in patients with diagnosed squamous cell carcinoma of the oral cavity. STUDY DESIGN: Prospective analytic study. METHODS: Subjects for this single institution, institutional review board-approved study were recruited from among patients undergoing surgical resection for squamous cell cancer of the oral cavity...
July 28, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28743666/biological-significance-of-5-hydroxymethylcytosine-in-oral-epithelial-dysplasia-and-oral-squamous-cell-carcinoma
#11
Maria Carolina Cuevas-Nunez, Camilla Borges F Gomes, Sook-Bin Woo, Matthew R Ramsey, Xiaoxin L Chen, Shuyun Xu, Ting Xu, Qian Zhan, George F Murphy, Christine G Lian
OBJECTIVES: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC. STUDY DESIGN: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC...
June 16, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28739686/chemoprevention-by-quercetin-of-oral-squamous-cell-carcinoma-by-suppression-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-dmba-treated-hamsters
#12
Wen Zhang, Gang Yin, Jianguo Dai, Y U Sun, Robert M Hoffman, Zhijian Yang, Yuan Fan
BACKGROUND/AIM: The aim of this study was to investigate the effects of the flavonoid quercetin on chemoprevention of oral squamous cell carcinoma (OSCC). The study involved molecular signaling pathways in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. MATERIALS AND METHODS: DMBA (0.5%) was painted at the right buccal pouches of hamsters for 14 weeks to induce carcinoma. DMBA-treated hamsters received simultaneous doses of quercetin...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28731047/targeted-next-generation-sequencing-supports-epidermoid-metaplasia-of-the-esophagus-as-a-precursor-to-esophageal-squamous-neoplasia
#13
Aatur D Singhi, Christina A Arnold, Dora M Lam-Himlin, Marina N Nikiforova, Lysandra Voltaggio, Marcia I Canto, Kevin M McGrath, Elizabeth A Montgomery
Esophageal epidermoid metaplasia is a rare condition that involves the proximal-to-middle third of the esophagus. It is sharply demarcated and defined histologically by epithelial hyperplasia, a prominent granular cell layer, and superficial hyperorthokeratosis. In addition, preliminary studies have suggested an association between esophageal epidermoid metaplasia and esophageal squamous neoplasia (squamous dysplasia and esophageal squamous cell carcinoma). To further characterize esophageal epidermoid metaplasia and better define its relationship to squamous neoplasia of the esophagus, we performed targeted next-generation sequencing on uninvolved esophageal squamous mucosa and matching esophageal epidermoid metaplasia specimens from 18 patients...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28725300/epstein-barr-virus-ebv-associated-epithelial-and-non-epithelial-lesions-of-the-oral-cavity
#14
REVIEW
Kentaro Kikuchi, Harumi Inoue, Yuji Miyazaki, Fumio Ide, Masaru Kojima, Kaoru Kusama
Epstein-Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gland tumor, gastric carcinoma and breast carcinoma. In terms of oral disease, there have been several reports of EBV-related oral squamous cell carcinoma (OSCC) worldwide...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28688684/early-detection-of-squamous-cell-carcinoma-in-carcinogen-induced-oral-cancer-rodent-model-by-ratiometric-activatable-cell-penetrating-peptides
#15
Dina V Hingorani, Aaron J Lemieux, Joseph R Acevedo, Heather L Glasgow, Suraj Kedarisetty, Michael A Whitney, Alfredo A Molinolo, Roger Y Tsien, Quyen T Nguyen
OBJECTIVES: Ratiometric cell-penetrating-peptides (RACPP) are hairpin-shaped molecules that undergo cleavage by tumor-associated proteases resulting in measurable Cy5:Cy7 fluorescence ratiometric change to label cancer in vivo. We evaluated an MMP cleavable RACPP for use in the early detection of malignant lesions in a carcinogen-induced rodent tumor model. METHODS: Wild-type immune-competent mice were given 4-nitroquinoline-oxide (4NQO) for 16weeks. Oral cavities from live mice that had been intravenously administered MMP cleavable PLGC(Me)AG-RACPP were serially imaged from week 11 through week 21 using white-light reflectance and Cy5:Cy7 ratiometric fluorescence...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28687439/subsquamous-intestinal-metaplasia-is-common-in-treatment-na%C3%A3-ve-barrett-s-esophagus
#16
Michael J Bartel, Amitabh Srivastava, Stuart Gordon, Richard I Rothstein, Heiko Pohl
BACKGROUND AND AIMS: Barrett's intestinal metaplasia may extend beneath normal squamous epithelium at the squamocolumnar junction (SCJ) and therefore escape surveillance biopsy sampling. The prevalence of subsquamous intestinal metaplasia (SSIM) in patients undergoing Barrett's esophagus (BE) surveillance is unknown. Our aim was to examine the prevalence and distribution of SSIM proximal to the SCJ in patients undergoing BE surveillance. METHODS: We enrolled consecutive patients with biopsy specimen-proven BE...
July 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28685798/cyto-colpo-histologic-correlation-about-an-analytical-study-of-120-colposcopies
#17
Olfa Slimani, Riadh Ben Temim, Tahar Makhlouf, Nabil Mathlouthi, Leila Attia
PROBLEM: Cervical cancer is the second gynecological cancer Tunisian women after breast. This is a sexually transmitted disease including the role of HPV has been proven. Cervical cancer screening is possible due to the accessibility of the cervix with a speculum examination and implementation of cervical smear. AIM OF THE WORK: To study the epidemiological and clinical data of patients, analyze the results of the Pap test, colposcopy and cervical biopsy staging are the lesions observed in colposcopy, compare the results of smears, colposcopy and cervical biopsy...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28679629/evaluation-of-ethyl-gallate-for-its-antioxidant-and-anticancer-property-against-chemical-induced-tongue-carcinogenesis-in-mice
#18
Shalini Mohan, Kalaivani Thiagarajan, Rajasekaran Chandrasekaran
Cancer raised in the oral cavity is one of the major causes of mortality worldwide and demand immediate attention. Regardless of the use of advanced treatment for oral cancer, successful treatment with cancer survival is less. Currently available drugs are though effective against cancer, treatment without toxic effects remains essential. This is quiet challenging leading to the identification of natural bioactive compounds for oral cancer treatment. Thus, a plant extract rich in phenolics was preferred to study the cellular, biochemical and molecular changes associated with oral carcinogenesis...
July 5, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28677822/spectroscopic-characterization-of-oral-epithelial-dysplasia-and-squamous-cell-carcinoma-using-multiphoton-autofluorescence-micro-spectroscopy
#19
Rahul Pal, Kert Edward, Liang Ma, Suimin Qiu, Gracie Vargas
OBJECTIVE: Multiphoton autofluorescence microscopy (MPAM) has shown potential in identifying features that are directly related to tissue microstructural and biochemical changes throughout epithelial neoplasia. In this study, we evaluate the autofluorescence spectral characteristics of neoplastic epithelium in dysplasia and oral squamous cell carcinoma (OSCC) using multiphoton autofluorescence spectroscopy (MPAS) in an in vivo hamster model of oral neoplasia in order to identify unique signatures that could be used to delineate normal oral mucosa from neoplasia...
July 5, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28664668/human-papillomavirus-related-carcinoma-with-adenoid-cystic-like-features-a-series-of-5-cases-expanding-the-pathologic-spectrum
#20
Jen-Fan Hang, Min-Shu Hsieh, Wing-Yin Li, Jo-Yu Chen, Shih-Yao Lin, Shih-Hao Liu, Chin-Chen Pan, Ying-Ju Kuo
AIMS: Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a newly described entity of the sinonasal tract. In this study, we evaluated histomorphology, immunophenotype, and molecular testing to identify potentially helpful features in distinguishing it from classical adenoid cystic carcinoma (AdCC). METHODS AND RESULTS: We retrospectively collected 5 HPV-related carcinomas with adenoid cystic-like features and 14 AdCCs of the sinonasal tract...
June 30, 2017: Histopathology
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