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Squamous dysplasia

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https://www.readbyqxmd.com/read/27908632/risk-of-persistent-and-recurrent-cervical-neoplasia-following-incidentally-detected-adenocarcinoma-in-situ
#1
Aime Munro, Jim Codde, Katrina Spilsbury, Nerida Steel, Colin J R Stewart, Stuart G Salfinger, Jason Tan, Ganendra R Mohan, Yee Leung, James Semmens, Peter O'Leary, Vincent Williams, Paul A Cohen
BACKGROUND: Adenocarcinoma-in-situ (AIS) of the uterine cervix is a precursor to cervical adenocarcinoma and may co-exist with both adenocarcinoma and high-grade squamous dysplasia (cervical intraepithelial neoplasia (CIN) 2 and 3). Up to 60% of AIS lesions are detected incidentally following excisional biopsies performed for the treatment of CIN 2/3. To date there are no data regarding risk factors for persisting or progressive cervical neoplasia in these patients. OBJECTIVE: To investigate patient outcomes following incidentally detected cervical AIS after loop electrosurgical excision procedure (LEEP) or cold knife cone (CKC) biopsy performed for the treatment of high-grade cervical intraepithelial neoplasia (CIN)...
November 28, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27900245/image-analysis-assisted-study-of-mitotic-figures-in-oral-epithelial-dysplasia-and-squamous-cell-carcinoma-using-differential-stains
#2
Ankita Tandon, Narendra Nath Singh, V R Brave, Gadiputi Sreedhar
BACKGROUND: Mitosis is a process of cell division resulting in two genetically equivalent daughter cells. Excessive proliferation of cells due to mitosis is the hallmark in pre cancer and cancer. AIMS: This study was conducted to count the number of mitotic figures in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma in both Hematoxylin and Eosin (H&E) and Crystal Violet stained sections. Also the overall number of mitotic figures with both stains were compared along with the evaluation of staining efficacy of both the stains...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899988/mtor-downstream-effectors-4ebp1-and-eif4e-are-overexpressed-and-associated-with-hpv-status-in-precancerous-lesions-and-carcinomas-of-the-uterine-cervix
#3
Aristidis Asimomytis, Maria Karanikou, Alexander Rodolakis, Anna Vaiopoulou, Paraskevi Tsetsa, George Creatsas, Theodoros Stefos, Aristidis Antsaklis, Efstratios Patsouris, George Z Rassidakis
The present study aims to investigate the expression levels of two critical mammalian target of rapamycin (mTOR) downstream effectors, 4E binding protein 1 (4EBP1) and eukaryotic initiation factor 4E (eIF4E) proteins, in precancerous squamous intraepithelial lesions and cancer of the uterine cervix, and their association with human papilloma virus (HPV) infection status. Uterine cervical biopsies from 73 patients were obtained, including 40 fresh-frozen samples and 42 archival formalin-fixed, paraffin-embedded tissue specimens...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889544/the-role-of-eus-in-patients-with-suspected-barrett-s-esophagus-with-high-grade-dysplasia-or-early-esophageal-adenocarcinoma-impact-on-endoscopic-therapy
#4
Michael J Bartel, Timothy Wallace, Rene Gomez, Massimo Raimondo, Herbert C Wolfsen, Timothy A Woodward, Michael B Wallace
BACKGROUND AND AIMS: Endoscopic therapy is the standard treatment for high-grade dysplasia and some cases of T1a esophageal adenocarcinoma (EAC), but it is not appropriate for deeply invasive disease. Data on the value of EUS for patient selection for endoscopic or surgical resection are conflicting. We investigated the outcome of esophageal EUS for the staging and treatment selection of patients with treatment-naïve, premalignant Barrett's esophagus (BE) and suspected superficial EAC...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27889035/anal-dysplasia
#5
REVIEW
Craig A Messick, Miguel A Rodriguez-Bigas
Anal dysplasia is a cytopathology term describing specific squamous cell morphology and represents a varying degree of benign changes. Often a source of confusion, the current iteration includes two types, low-grade and high-grade, and carries significant clinical implications. This article updates readers on the current definition of anal dysplasia, describes its incidence and prevalence, defines high-risk populations, and highlights diagnostics, treatment, and long-term management strategies for patients with anal dysplasia...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27886713/automated-classification-of-pap-smear-images-to-detect-cervical-dysplasia
#6
Kangkana Bora, Manish Chowdhury, Lipi B Mahanta, Malay Kumar Kundu, Anup Kumar Das
BACKGROUND AND OBJECTIVES: The present study proposes an intelligent system for automatic categorization of Pap smear images to detect cervical dysplasia, which has been an open problem ongoing for last five decades. METHODS: The classification technique is based on shape, texture and color features. It classifies the cervical dysplasia into two-level (normal and abnormal) and three-level (Negative for Intraepithelial Lesion or Malignancy, Low-grade Squamous Intraepithelial Lesion and High-grade Squamous Intraepithelial Lesion) classes reflecting the established Bethesda system of classification used for diagnosis of cancerous or precancerous lesion of cervix...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27883177/feasibility-of-clinical-detection-of-cervical-dysplasia-using-angle-resolved-low-coherence-interferometry-measurements-of-depth-resolved-nuclear-morphology
#7
Derek Ho, Tyler K Drake, Karen K Smith-McCune, Teresa M Darragh, Loris Y Hwang, Adam Wax
This study sought to establish the feasibility of using in situ depth-resolved nuclear morphology measurements for detection of cervical dysplasia. Forty (40) enrolled patients received routine cervical colposcopy with angle-resolved low coherence interferometry (a/LCI) measurements of nuclear morphology. a/LCI scans from 63 tissue sites were compared to histopathological analysis of co-registered biopsy specimens which were classified as benign, low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL)...
November 24, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27880766/sox2-and-pi3k-cooperate-to-induce-and-stabilize-a-squamous-committed-stem-cell-injury-state-during-lung-squamous-cell-carcinoma-pathogenesis
#8
Bo Ram Kim, Emily Van de Laar, Michael Cabanero, Shintaro Tarumi, Stefan Hasenoeder, Dennis Wang, Carl Virtanen, Takaya Suzuki, Bizhan Bandarchi, Shingo Sakashita, Nhu An Pham, Sharon Lee, Shaf Keshavjee, Thomas K Waddell, Ming-Sound Tsao, Nadeem Moghal
Although cancers are considered stem cell diseases, mechanisms involving stem cell alterations are poorly understood. Squamous cell carcinoma (SQCC) is the second most common lung cancer, and its pathogenesis appears to hinge on changes in the stem cell behavior of basal cells in the bronchial airways. Basal cells are normally quiescent and differentiate into mucociliary epithelia. Smoking triggers a hyperproliferative response resulting in progressive premalignant epithelial changes ranging from squamous metaplasia to dysplasia...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27866683/interventional-laser-surgery-for-oral-potentially-malignant-disorders-a-longitudinal-patient-cohort-study
#9
P J Thomson, M L Goodson, K Cocks, J E Turner
Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation risk. No clear management guidelines exist and it is unclear from the literature whether early diagnosis and intervention prevents cancer...
November 17, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27865370/hypermethylated-znf582-and-pax1-are-effective-biomarkers-for-detection-of-oral-dysplasia-and-oral-cancer
#10
Shih-Jung Cheng, Chi-Feng Chang, Jang-Jaer Lee, Hsin-Ming Chen, Huei-Jen Wang, Yu-Ligh Liou, Carolyn Yen, Chun-Pin Chiang
OBJECTIVES: This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS: Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral precancer patients, and 95 oral squamous cell carcinoma patients. Methylation levels of the five genes were quantified by real-time methylation-specific PCR after bisulfite conversion...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865360/langerhans-cell-number-is-a-strong-and-independent-prognostic-factor-for-head-and-neck-squamous-cell-carcinomas
#11
Nadège Kindt, Géraldine Descamps, Imelda Seminerio, Justine Bellier, Jérôme R Lechien, Charles Pottier, Denis Larsimont, Fabrice Journé, Philippe Delvenne, Sven Saussez
OBJECTIVES: Head and neck squamous cell carcinomas (HNSCCs) exhibit great biological heterogeneity and relatively poor prognosis. Tobacco and alcohol consumption is involved in the cause of the majority of these cancers, but over the last several years, Human Papilloma Virus (HPV) infection has increased specifically in oropharyngeal cancers and become an additional risk factor. Here, we evaluated the number of Langerhans cells (LCs) in HNSCC and reporting its prognostic power in comparison to other risk factors...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27864932/hpv-status-and-favorable-outcome-in-vulvar-squamous-cancer
#12
Katie Wakeham, Kim Kavanagh, Kate Cuschieri, David Millan, Kevin G Pollock, Sarah Bell, Kevin Burton, Nicholas S Reed, Sheila V Graham
It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. We have conducted a detailed population-based study to examine rates of progression of VIN to VSCC, type-specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27860386/raman-spectroscopy-can-discriminate-between-normal-dysplastic-and-cancerous-oral-mucosa-a-tissue-engineering-approach
#13
Salman A Mian, Ceyla Yorucu, Muhammad Saad Ullah, Ihtesham U Rehman, Helen E Colley
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Squamous cell carcinoma, the primary cause of HNC, evolves from normal epithelium through dysplasia before invading the connective tissue to form a carcinoma. However, less than 18% of suspicious oral lesions progress to cancer, with diagnosis currently relying on histopathological evaluation, which is invasive and time consuming. A non-invasive, real-time, point-of-care method could overcome these problems and facilitate regular screening...
November 10, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27855375/three-circulating-lncrna-predict-early-progress-of-esophageal-squamous-cell-carcinoma
#14
Hai-Bo Hu, Hong-Ying Jie, Xiang-Xiang Zheng
BACKGROUND/AIMS: Previous studies revealed that circulating (either from plasma or serum) long non-coding RNA may predict the occurrence or prognosis of multiple human malignant tumors. In this study, we mainly explored whether circulating lncRNAs can be utilized as biomarkers predicting the development of human esophageal squamous cell carcinoma (ESCC). METHODS: LncRNA microarray was applied to screen the potential biomarkers for ESCC. Each group contained three individual plasma samples...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27849339/immunohistochemical-study-of-p21-and-bcl-2-in-leukoplakia-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma
#15
Rakesh V Sutariya, Bhari Sharanesha Manjunatha
BACKGROUND: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia). OBJECTIVES: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27843896/surgical-reconstruction-of-ocular-surface-tumors-using-fibrin-sealant-tissue-adhesive
#16
Aline Roseane Queiroz de Paiva, Larissa Abreu de Azevedo Fraga, Virgínia Laura Lucas Torres
PURPOSE: To evaluate the surgical outcomes of ocular surface reconstruction in corneal-conjunctival tumors using fibrin tissue adhesive. METHODS: A prospective noncomparative study was performed between May 2013 and February 2015. Patients were submitted to routine surgical procedure for corneal-conjunctival tumor excision followed by amniotic membrane graft transplantation using fibrin tissue adhesive (Evicel®, Omrix Biopharmaceuticals Ltd., Israel). Results were assessed on the 1st, 7th, 15th and 30th postoperative days to analyze subjective complaints, adhesiveness and positioning of the graft, potential complications and recurrences...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27837320/a-retrospective-study-of-endoscopic-resection-for-368-patients-with-early-esophageal-squamous-cell-carcinoma-or-precancerous-lesions
#17
Dongxian Jiang, Xuquan Li, Haixing Wang, Chen Xu, Xiaojing Li, Akesu Sujie, Haiying Zeng, Yingyong Hou, Yunshi Zhong
BACKGROUND: To retrospectively investigate the clinicopathological features and prognosis of early esophageal squamous cell neoplasm (ESCN) treated with endoscopic resection (ER), especially, to compare the prognosis in patients with sm2 cancer and non-sm2 cancer. METHODS: From 2007 to 2013, 368 patients were included in our analysis. RESULTS: The patients were 252 (68.5 %) men and 116 (31.5 %) women with a median age of 61 (range 16-84 years) years...
November 11, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27818592/predicting-malignant-transformation-of-esophageal-squamous-cell-lesions-by-combined-biomarkers-in-an-endoscopic-screening-program
#18
Hao Zhang, Hao Li, Qing Ma, Fang-Yan Yang, Tao-Yu Diao
AIM: To determine the association of p53, carcinoembryonic antigen (CEA) and CA19-9 protein expression with esophageal carcinogenesis. METHODS: An iodine staining endoscopic screening program of esophageal lesions was carried out in the high-incidence area of Feicheng County, China. Seventy-seven patients with basal cell hyperplasia (BCH), 247 with low-grade dysplasia (LGD), 51 with high-grade dysplasia (HGD), 134 with invasive cancer, and 80 normal controls diagnosed by mucous membrane biopsy pathology were enrolled...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27807370/role-of-endoscopy-in-early-oesophageal-cancer
#19
REVIEW
Jayan Mannath, Krish Ragunath
Incidence of oesophageal adenocarcinoma has increased exponentially in the West over the past few decades. Following detection of advanced cancers, 5-year survival rates remain bleak, making identification of early neoplasia, which has a better outcome, important. Detection of subtle oesophageal lesions during endoscopy can be challenging, and advanced imaging techniques might improve their detection. High-definition endoscopy has become a standard in most endoscopy centres, and this technology probably provides better delineation of mucosal features than standard-definition endoscopy...
November 3, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27801760/the-prevalence-of-lichen-sclerosus-in-patients-with-vulvar-squamous-cell-carcinoma
#20
Jonathan J Davick, Megan Samuelson, James T Krone, Colleen K Stockdale
Women with vulvar lichen sclerosus (LS) have an increased risk of developing differentiated vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma (SCC). Our primary aim was to determine the prevalence of LS among women with vulvar SCC. All patients who underwent excision for invasive SCC of the vulva from January 1, 2009 to December 31, 2013 were identified by searching our institution's electronic laboratory information system (n=111). The vulvar excision specimens from these patients were reviewed for the presence of adjacent LS...
October 31, 2016: International Journal of Gynecological Pathology
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