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https://www.readbyqxmd.com/read/28922414/a-nonrandomized-trial-of-vitamin-d-supplementation-for-barrett-s-esophagus
#1
Linda C Cummings, Prashanthi N Thota, Joseph E Willis, Yanwen Chen, Gregory S Cooper, Nancy Furey, Beth Bednarchik, Bronia M Alashkar, John Dumot, Ashley L Faulx, Stephen P Fink, Adam M Kresak, Basel Abusneineh, Jill Barnholtz-Sloan, Patrick Leahy, Martina L Veigl, Amitabh Chak, Sanford D Markowitz
BACKGROUND: Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett's esophagus (BE). We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE. METHODS: BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol) 50,000 international units weekly plus a proton pump inhibitor for 12 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28919616/detection-of-human-papilloma-virus-by-molecular-method-from-patients-attending-at-colposcopy-clinic-of-mymensingh-medical-college-hospital-mymensingh
#2
H Begum, M A Hossain, S K Paul, S A Nasreen, S Ahmed, S Nahar, S Monwar, F Nahar, S Roy, S A Abdullah, S Abedin, M U Ahmed, T K Barman
Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is considered as the main cause of invasive cervical cancer and cervical intra-epithelial neoplasia. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers. So HPV DNA testing for screening of cervical cancers may play a potential role in early detection and management of cervical cancer. With above background a cross sectional study was undertaken to estimate the prevalence and to identify the associated risk factors of human Papillomavirus infection among Visual Inspection with Acetic acid (VIA) positive women attending at colposcopy clinic of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from July 2013 to December 2014...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28904918/evaluation-of-genetic-polymorphisms-in-glutathione-s-transferase-theta1-glutathione-s-transferase-mu1-and-glutathione-s-transferase-mu3-in-oral-leukoplakia-and-oral-squamous-cell-carcinoma-with-deleterious-habits-using-polymerase-chain-reaction
#3
Ayyagari Kameswara Rao, Peela Parameswar, Sumit Majumdar, Divya Uppala, Sreekanth Kotina, Naga Himabindu Vennamaneni
CONTEXT: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. As per previous studies, most patients who develop oral cancer are elderly males who are heavy users of tobacco and alcohol; however, the incidence is increasing in younger individuals and in those who neither smoke nor drink. Many of the genes that code for the detoxification enzymes are polymorphic with abnormal activity profiles. AIMS AND OBJECTIVES: The aim of this study was to evaluate the risk of development of oral leukoplakia (OLP) and OSCC in glutathione S-transferase polymorphisms genes in the east coast of Andhra Pradesh population with tobacco consumption habit and habit-free controls using polymerase chain reaction (PCR-restriction fragment length polymorphism)...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28903838/prognostic-potential-of-n-cadherin-in-oral-squamous-cell-carcinoma-via-immunohistochemical-methods
#4
Betina Chandolia, Jai Parkash Rajliwal, Manas Bajpai, Manika Arora
OBJECTIVE: To assess the prognostic potential for N-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia. STUDY DESIGN: Across-sectional study, analytical study. PLACE AND DURATION OF STUDY: Maharishi Markandeshwar College of Dental Science Research (MMCDSR), Ambala, India, from 2011 to 2014. METHODOLOGY: Immunohistochemistry was used to observe the N-cadherin expression in 100 cases having epithelium with normal oral mucosa, oral epithelial dysplastic lesions and oral squamous cell carcinoma (OSCC)...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28900112/genomic-comparison-of-esophageal-squamous-cell-carcinoma-and-its-precursor-lesions-by-multi-region-whole-exome-sequencing
#5
Xi-Xi Chen, Qian Zhong, Yang Liu, Shu-Mei Yan, Zhang-Hua Chen, Shan-Zhao Jin, Tian-Liang Xia, Ruo-Yan Li, Ai-Jun Zhou, Zhe Su, Yu-Hua Huang, Qi-Tao Huang, Li-Yun Huang, Xing Zhang, Yan-Na Zhao, Jin-Ping Yun, Qiu-Liang Wu, Dong-Xin Lin, Fan Bai, Mu-Sheng Zeng
Esophageal squamous dysplasia is believed to be the precursor lesion of esophageal squamous cell carcinoma (ESCC); however, the genetic evolution from dysplasia to ESCC remains poorly understood. Here, we applied multi-region whole-exome sequencing to samples from two cohorts, 45 ESCC patients with matched dysplasia and carcinoma samples, and 13 tumor-free patients with only dysplasia samples. Our analysis reveals that dysplasia is heavily mutated and harbors most of the driver events reported in ESCC. Moreover, dysplasia is polyclonal, and remarkable heterogeneity is often observed between tumors and their neighboring dysplasia samples...
September 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28891852/condyloma-acuminatum-anal-intraepithelial-neoplasia-and-anal-cancer-in-the-setting-of-hiv-do-we-really-understand-the-risk
#6
Edward A Fazendin, Alexander J Crean, Jessica M Fazendin, Robert J Kucejko, Harkenwar S Gill, Juan L Poggio, David E Stein
BACKGROUND: The gold standard for surveillance of patients with anal lesions is unclear. OBJECTIVE: The aim of this study was to stratify patients for risk of progression of disease and to determine appropriate intervals for surveillance of patients with anal disease. DESIGN: This was a retrospective chart review for patients treated for anal lesions between 2007 and 2014. Only patients with ≥1 year of follow-up from index evaluation, pathology, documented physical examination, and anoscopy findings were included for analysis...
October 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28891195/prevalence-of-synchronous-bilateral-tonsil-squamous-cell-carcinoma-a-retrospective-study
#7
Malene Sine Rokkjaer, Tejs Ehlers Klug
OBJECTIVES: The prevalence of synchronous bilateral tonsil cancer remains unexplored. To date, only 38 cases have been described in the literature. With an aim to substantiate the Danish recommendation of performing bilateral tonsillectomy in patients with suspected or proven tonsil cancer and in patients with cervical carcinoma metastasis from an unknown primary tumour, the current study was undertaken to determine the prevalence of synchronous bilateral tonsil cancer. DESIGN: A retrospective review of all patients diagnosed with tonsil cancer in the period 2000-2015, Aarhus University Hospital, Denmark, was performed...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28881898/performance-characteristics-of-optical-coherence-tomography-in-assessment-of-barrett-s-esophagus-and-esophageal-cancer-systematic-review
#8
D R Kohli, M L Schubert, A M Zfass, T U Shah
Optical coherence tomography (OCT) can generate high-resolution images of the esophagus that allows cross-sectional visualization of esophageal wall layers. We conducted a systematic review to assess the utility of OCT for diagnosing of esophageal intestinal metaplasia (IM; Barrett's esophagus BE)), dysplasia, cancer and staging of early esophageal cancer. English language human observational studies and clinical trials published in PubMed and Embase were included if they assessed any of the following: (i) in-vivo features and accuracy of OCT at diagnosing esophageal IM, sub-squamous intestinal metaplasia (SSIM), dysplasia, or cancer, and (ii) accuracy of OCT in staging esophageal cancer...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28878914/a-novel-keratin-13-variant-in-a-four-generation-family-with-white-sponge-nevus
#9
Stephanie B de Haseth, Egbert Bakker, Maarten H Vermeer, Hakima El Idrissi, Tjalling Bosse, Vincent T H B M Smit, Anna Terron-Kwiatkowski, W H Irwin McLean, Alexander A W Peters, Frederik J Hes
We report a novel KRT13 germ line variant that causes white sponge nevus (WSN) with mucosal dysplasia. Genital, vaginal, and cervical WSN were observed in four female patients, of whom two had premalignant cervical lesions at young age. Two of the 12 patients with oral WSN developed oral squamous cell carcinoma.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28870901/nicotinamide-phosphoribosyl-transferase-a-reliable-marker-of-progression-in-cervical-dysplasia
#10
Moiz Vora, Lubna A Alattia, Junaid Ansari, Menchu Ong, James Cotelingam, Domenico Coppola, Rodney Shackelford
BACKGROUND/AIM: Nicotinamide phosphoribosyl transferase (Nampt) catalyses the rate-limiting step of the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway. Nampt is highly expressed in several epithelial and mesenchymal neoplasms, where is promotes cell-cycle progression ans chemotherapy resistance. To our knowledge, alterations in Nampt expression have not been examined in cervical intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC). MATERIALS AND METHODS: We performed immunohistochemical analysis for Nampt using tissue microarrays on 14 samples of benign cervical squamous epithelium and 15 CIN I, 15 CIN II, and 13 samples of CIN III...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28860942/accuracy-of-cervical-cytology-comparison-of-diagnoses-of-100-pap-smears-read-by-four-pathologists-at-three-hospitals-in-norway
#11
Sveinung Wergeland Sørbye, Pål Suhrke, Berit Wallem Revå, Jannicke Berland, Ramona Johansen Maurseth, Khalid Al-Shibli
BACKGROUND: Cervical cancer can be prevented by early detection and treatment for precancerous lesions. Since 1995, there has been a national cervical cancer screening program in Norway, where women aged 25-69 years are recommended to take Pap smears every three years. There are 17 cytology laboratories covering a population of 5 million people. The detection rate of cervical abnormalities varies from laboratory to laboratory. We wanted to investigate the accuracy of cytology diagnoses by four different pathologists at three different hospitals in Norway...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28860646/metaplasia-tissue-injury-adaptation-and-a-precursor-to-the-dysplasia-cancer-sequence
#12
REVIEW
Veronique Giroux, Anil K Rustgi
Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by environmental stimuli, which may act in concert with the deleterious effects of microorganisms and inflammation. The cell of origin for intestinal metaplasia in the oesophagus and stomach and for pancreatic acinar-ductal metaplasia has been posited through genetic mouse models and lineage tracing but has not been identified in other types of metaplasia, such as squamous metaplasia...
September 1, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28858374/pten-allelic-loss-is-an-important-mechanism-in-the-late-stage-of-development-of-oral-leukoplakia-into-oral-squamous-cell-carcinoma
#13
Ligia Akiko Ninokata Miyahara, Flávia Sirotheau Corrêa Pontes, Rommel Mario Rodríguez Burbano, Nicolau Conte Neto, Douglas Magno Guimarães, Felipe Paiva Fonseca, Hélder Antônio Rebelo Pontes
OBJECTIVES: The aim of this study is to analyse allelic loss of the PTEN gene and its protein immunoexpression in dysplastic oral lesions and oral squamous cell carcinomas (OSCCs). MATERIALS AND METHODS: Samples were collected from 153 patients (20 ranulas used as a control - C, 30 leukoplakias with mild dysplasia - MD, 30 leukoplakias with moderate to severe dysplasia - MSD, and 73 OSCC). PTEN protein expression was investigated using immunohistochemistry, and PTEN allelic loss was analysed by fluorescence in situ hybridisation (FISH)...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28857739/association-of-codon-72-polymorphism-of-p53-with-the-severity-of-cervical-dysplasia-e6-t350g-and-hpv16-variant-lineages-in-hpv16-infected-women
#14
George D Moschonas, Dimitris Tsakogiannis, Konstantinos A Lamprou, Eirini Mastora, Tilemachos G Dimitriou, Zaharoula Kyriakopoulou, Christine Kottaridi, Petros Karakitsos, Panayotis Markoulatos
PURPOSE: Polymorphic variability in the tumour-suppressor protein p53 at codon 72 has a considerable impact on cervical cancer development. The present study clarified the association between p53 codon 72 genotypes and the risk of cervical disease in Greek patients. We also examined whether the presence of specific p53 genotypes in combination with HPV16 variants or E6 T350G sequence variation can modify an individual's susceptibility to cervical disease. METHODOLOGY: The analysis of p53 genotypes was performed through PCR-RFLP...
August 31, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28855108/squamoid-morules-in-the-pseudoinvasive-foci-of-colonic-polyp-morphologically-mimic-invasive-carcinoma
#15
Hee Eun Lee, Vishal S Chandan, Chung-Ta Lee, Tsung-Teh Wu
Colorectal adenomas can show focal squamous differentiation or squamoid morules. We describe histologic findings of squamoid morules in the pseudoinvasive foci of colorectal polyps mimicking invasive carcinoma. Five colonic polyps with squamoid morules in the pseudoinvasive foci were collected. Histologic review and immunostains for cytokeratin (CK) 5/6, p63, synaptophysin, and chromogranin were performed on cases with squamoid morules. Forty-seven consecutive colorectal polyps with pseudoinvasion, none of which showed squamoid morules by histology review, and their clinicopathologic features were compared with the cases containing squamoid morules...
August 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/28846793/a-clinicopathologic-and-epidemiologic-study-of-chronic-white-lesions-in-the-oral-mucosa
#16
Sampurna Ghosh, Sudipta Pal, Soumya Ghatak, Somnath Saha, Surajit Biswas, Prabha Srivastava
Invasive oral squamous cell carcinoma is often preceded by the presence of clinically identifiable premalignant changes of the oral mucosa, including white lesions. We conducted a cross-sectional, observational study to assess the clinicopathologic and epidemiologic aspects of chronic oral mucosal white lesions to determine the necessity of early biopsy in these cases. Our study population was made up of 77 patients-50 males and 27 females, aged 15 to 70 years (mean: 42.9)-who presented with white lesions persisting for at least 4 weeks...
August 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28836534/determination-of-p16-overexpression-as-an-indicator-of-human-papillomavirus-infection-in-oral-dysplasia-and-carcinoma
#17
Adrija Pathak, Mahendra Singh, Asha Agarwal, Sonal Amit
CONTEXT: Oral and pharyngeal cancer, grouped together, is the sixth most common cancer in the world. In the past few years, human papillomavirus (HPV) infection has been suggested as a risk factor for oral cancer apart from traditional risk factors such as smoking, tobacco, and alcohol consumption. AIMS: The aim of this study was to determine HPV status of the tumors using polymerase chain reaction (HPV-DNA PCR) and p16 immunostaining and to correlate p16 overexpression as an indicator of HPV-associated oral dysplasia and carcinoma...
July 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28836525/a-study-of-complexity-of-oral-mucosa-using-fractal-geometry
#18
S R Shenoi, Payal Peshwani, Anup Garg, Rohit Moharil
BACKGROUND: The oral mucosa lining the oral cavity is composed of epithelium supported by connective tissue. The shape of the epithelial-connective tissue interface has traditionally been used to describe physiological and pathological changes in the oral mucosa. AIM: The aim is to evaluate the morphometric complexity in normal, dysplastic, well-differentiated, and moderately differentiated squamous cell carcinoma (SCC) of the oral mucosa using fractal geometry...
July 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28834425/promotion-of-cell-proliferation-by-the-proto-oncogene-dek-enhances-oral-squamous-cell-carcinogenesis-through-field-cancerization
#19
Takayuki Nakashima, Hiroyuki Tomita, Akihiro Hirata, Kazuhisa Ishida, Kenji Hisamatsu, Yuichiro Hatano, Tomohiro Kanayama, Ayumi Niwa, Kei Noguchi, Keizo Kato, Tatsuhiko Miyazaki, Takuji Tanaka, Toshiyuki Shibata, Akira Hara
Oral squamous cell carcinoma (OSCC) develops through a multistep carcinogenic process involving field cancerization. The DEK gene is a proto-oncogene with functions in genetic and epigenetic modifications, and has oncogenic functions, including cellular proliferation, differentiation, and senescence. DEK overexpression is associated with malignancies; however, the functional roles of DEK overexpression are unclear. We demonstrated that DEK-expressing cells were significantly increased in human dysplasia/carcinoma in situ and OSCC...
August 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28833675/efficacy-of-oral-brush-biopsy-in-potentially-malignant-disorder-management
#20
M L Goodson, D R Smith, P J Thomson
BACKGROUND: Oral potentially malignant disorders (PMD) harbour unpredictable risk for squamous cell carcinoma development. Current management requires tissue biopsy for histopathology characterisation, dysplasia grading and targeted intervention to "high-risk" lesions, although evidence-based guidelines are limited and diagnoses subjective. This study investigated the use of adjunctive oral brush biopsy techniques during the management of PMD in a UK hospital population. METHODS: Retrospective review of a 310 PMD patient cohort presenting to Maxillofacial Surgery in Newcastle upon Tyne with new, single-site lesions between December 2009 and May 2014...
August 21, 2017: Journal of Oral Pathology & Medicine
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