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Proliferative verrucous leukoplakia

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https://www.readbyqxmd.com/read/27900324/low-expression-of-angiotensinogen-and-dipeptidyl-peptidase-1-in-saliva-of-patients-with-proliferative-verrucous-leukoplakia
#1
Isadora Luana Flores, Alan Roger Santos-Silva, Ricardo Della Coletta, Adriana Franco Paes Leme, Marcio Ajudarte Lopes
AIM: To elucidate the profile of the salivary proteome. METHODS: Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests. RESULTS: A total of two hundred and eighty-three proteins were confidently identified in saliva...
November 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27891495/proliferative-verrucous-leukoplakia-a-perpetuating-ambiguity
#2
Monica Mehendiratta, Kanu Jain
No abstract text is available yet for this article.
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27866683/interventional-laser-surgery-for-oral-potentially-malignant-disorders-a-longitudinal-patient-cohort-study
#3
P J Thomson, M L Goodson, K Cocks, J E Turner
Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation risk. No clear management guidelines exist and it is unclear from the literature whether early diagnosis and intervention prevents cancer...
November 17, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27865210/exophytic-verrucous-hyperplasia-of-the-oral-cavity-%C3%A2-application-of-standardized-criteria-for-diagnosis-from-a-consensus-report
#4
Binti Zain Rosnah, George Kallarakkal Thomas, Ramanathan Anand, Kim Jin, Tilakaratne Wm, Takata Takashi, Warnakulasuriya Saman, Kumar Hazarey Vinay, Rich Alison, Mohd Hussaini Haizal, Jalil Ajura
Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Apart from virus-associated lesions, VPLs harboring malignant potential or behaviour such as verrucous carcinoma, proliferative verrucous leukoplakia, oral verrucous hyperplasia (OVH), oral papillary squamous cell carcinoma (PSCC) and oral conventional squamous cell carcinoma with papillary features (CSCC) need to be further clarified for better understanding of their predictable biologic behavior and appropriate treatment...
January 9, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27681951/cancer-associated-fibroblasts-are-an-infrequent-finding-in-the-microenvironment-of-proliferative-verrucous-leukoplakia-associated-squamous-cell-carcinoma
#5
Sharon J Akrish, Adi Rachmiel, Edmond Sabo, Marilena Vered, Ofer Ben-Izhak
BACKGROUND: Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca). METHODS: A retrospective clinicopathologic and immunohistochemical analysis of 97 tumor specimens from 78 patients (13 patients with proliferative verrucous leukoplakia-associated squamous cell carcinoma (n = 32) and conventional squamous cell carcinoma from the buccal mucosa, gingiva, and palate (n = 65) was conducted...
September 29, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27478070/a-proteomic-approach-to-compare-saliva-from-individuals-with-and-without-oral-leukoplakia
#6
Danielle Resende Camisasca, Lorena da Rós Gonçalves, Márcia Regina Soares, Vanessa Sandim, Fábio César Sousa Nogueira, Carlos Henrique Saraiva Garcia, Rodrigo Santana, Silvia Paula de Oliveira, Luisa Aguirre Buexm, Paulo Antônio Silvestre de Faria, Fernando Luiz Dias, Denise de Abreu Pereira, Russolina B Zingali, Gilda Alves, Simone Queiroz Chaves Lourenço
BACKGROUND: Oral leukoplakia is the most common potentially malignant disorder in the oral cavity and can precede carcinoma. This study aimed to identify possible oral leukoplakia salivary biomarkers. METHODS: Unstimulated saliva was collected from participants and protein concentration was determined. Proteins were then precipitated with cold acetone and separated using 2DE over a pH range of 3-10. Spot demarcation and matching were performed and protein identification was done through MS analysis...
July 29, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27461595/proliferative-verrucous-leukoplakia-an-update
#7
REVIEW
Anita Munde, Ravindra Karle
Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in elderly women, over 60 years at the time of diagnosis. The buccal mucosa and tongue are the most frequently involved sites...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27307679/diode-laser-in-treatment-of-recurrent-verrucous-leukoplakia
#8
Debanti Giri, Nitin Agarwal, Abhishek Sinha, Sunita Srivastava, Anuj Mishra
Laser first came into light in 1960 and had been used extensively in various fields of medicine. Laser has been experimented in the various dental field, and its utility is being recognized and established well in the dentistry. Lasers are widely used for a number of procedures such as cavity preparation, scaling, and root planning, surgical procedures like excision of soft tissue growths, etc., Improved healing, hemostasis, and sutureless excisions are some of the many advantages of laser over conventional treatment modalities...
April 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27031060/the-development-of-proliferative-verrucous-leukoplakia-in-oral-lichen-planus-a-preliminary-study
#9
M-J Garcia-Pola, S Llorente-Pendás, M González-Garcia, J-M García-Martín
BACKGROUND: Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus. MATERIAL AND METHODS: The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years. RESULTS: The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56...
2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/26960457/the-role-of-ki-67-p16-cd34-bcl-2-cyclooxygenase-2-in-the-pathogenesis-of-proliferative-verrucous-leukoplakia
#10
A Thennavan, A A Byatnal, M C Solomon, R A Radhakrishnan
CONTEXT: Proliferative verrucous leukoplakia (PVL) is a highly persistent and aggressive oral pre-malignant lesion with an obscure etiopathogenesis and a malignant transformation rate of 85-100%. AIMS: The aim of the present study is to assess the role of Ki-67, p16, CD34, Bcl-2, cyclooxygenase-2 (COX-2) in the spectrum of PVL to ascertain their role in its etiopathogenesis. SETTINGS AND DESIGN: A retrospective chart analysis was carried out on a series of seven confirmed cases of PVL, which were followed-up for 2 years...
October 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26837785/the-lichenoid-tissue-reactions-of-the-oral-mucosa-oral-lichen-planus-and-other-lichenoid-lesions
#11
Susan Müller
Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions and can have varied etiologies. Immune-mediated disorders, including lichen planus, mucous membrane pemphigoid, discoid lupus erythematosus, and graft-versus-host disease, can have clinical and histologic overlaps. Lichenoid reactions to dental materials, such as amalgam, or to many systemic drugs are also well documented. Dysplasia of the oral cavity at times can also express a lichenoid histology, which may mask the potentially cancerous component...
December 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26832120/-proliferative-verrucous-leukoplakia-three-cases-and-literature-review
#12
A Ottavioli, F Campana, J-H Catherine, E Massereau, J Del Grande, U Ordioni
BACKGROUND: The aim of this study was to collect epidemiological, aetiopathogenic, clinical, histological and therapeutic data concerning proliferative verrucous leucoplakia (PVL) and to report three new cases. PATIENTS AND METHODS: A literature review performed using the Medline database enabled us to collate 39 studies involving 607 cases. Three new cases were added. RESULTS: PVL is a rare disease characterized by extensive and multifocal oral leucoplakic lesions...
March 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/26488020/proliferative-verrucous-leukoplakia-may-initially-mimic-lichenoid-reactions
#13
Marcio Ajudarte Lopes, Patricia Feio, Alan Roger Santos-Silva, Pablo Agustin Vargas
Proliferative verrucous leukoplakia is an intriguing disease, which occurs particularly in women aged greater than 60 years, is not associated with tobacco and alcohol, and has a high risk of recurrence and malignant transformation. Although it is well known that the typical presentation is characterized by multifocal and verrucous white lesions, there is no description that its initial clinical presentation may simulate a lichenoid reaction.
October 16, 2015: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/26299096/7-cases-of-proliferative-verrucous-leukoplakia-the-need-for-a-high-clinical-suspicion-among-dental-practitioners
#14
Adepitan A Owosho, Elizabetg A Bilodeau, Kurt F Summersgill
Proliferative verrucous leukoplakia is a distinct precancerous condition with a high rate of recurrence and malignant transformation over time. Proliferative verrucous leukoplakia has no specific histopathologic presentation; therefore, emphases must be on clinical presentation and history to make a diagnosis; giving the need for a high clinical suspicion. This condition is very important for the general dentist to recognize. Here we describe the clinical and microscopic features of seven cases of proliferative verrucous leukoplakia, with two cases which demonstrated malignant transformation (hybrid carcinoma and squamous cell carcinoma)...
January 2015: Pennsylvania Dental Journal
https://www.readbyqxmd.com/read/26285537/seven-cases-of-proliferative-verrucous-leukoplakia-the-need-for-a-high-clinical-suspicion-among-dental-practitioners
#15
A Owosho, Elizabeth A Bilodeau, Kurt F Summersgill
Proliferative verrucous leukoplakia is a distinct precancerous condition with a high rate of recurrence and malignant transformation over time. Proliferative verrucous leukoplakia has no specific histopathologic presentation; therefore, emphases must be on clinical presentation and history to make a diagnosis giving the need for a high clinical suspicion. This condition is very important for the general dentist to recognize. Here we describe the clinical and microscopic features of seven cases of proliferative verrucous leukoplakia, with two cases which demonstrated malignant transformation (hybrid carcinoma and squamous cell carcinoma)...
June 2015: Journal of the Michigan Dental Association
https://www.readbyqxmd.com/read/26254143/salivary-and-serum-interleukin-6-levels-in-proliferative-verrucous-leukoplakia
#16
Leticia Bagan, Guillermo T Sáez, M Carmen Tormos, Carlos Labaig-Rueda, Judith Murillo-Cortes, Jose V Bagan
BACKGROUND: Cytokines and chemokines have been analysed in patients with oral squamous cell carcinoma and potentially malignant disorders. We selected interleukin-6 (IL-6) because it is a multifunctional interleukin reported to be altered in potentially malignant oral disorders and in malignant lesions. To date, this has not been evaluated or tested in proliferative verrucous leukoplakia (PVL), however. OBJECTIVES: This study aimed to analyse the differences in serum and saliva IL-6 levels among patients with PVL, oral squamous cell carcinoma (OSCC) and healthy controls and to examine the relationship between salivary IL-6 levels and the extent of the verrucous area...
May 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/26215020/oral-pathology-quiz-86-case-number-2-proliferative-verrucous-leukoplakia
#17
(no author information available yet)
No abstract text is available yet for this article.
2015: Journal of the New Jersey Dental Association
https://www.readbyqxmd.com/read/26097339/role-of-human-papillomavirus-in-oral-squamous-cell-carcinoma-and-oral-potentially-malignant-disorders-a-review-of-the-literature
#18
REVIEW
Shikha Gupta, Sunita Gupta
Human papillomaviruses (HPVs) are epitheliotropic viruses with an affinity for keratinocytes and are principally found in the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa. On the basis of high, but variable frequency of HPV in oral squamous cell carcinoma (OSCC), malignant potential of HPV infection has been hypothesized but not definitely confirmed. The aim of this review was to highlight the genomic structure and possible mechanism of infection and carcinogenesis by HPV in the oral mucosa and to review the frequency of HPV prevalence in OSCC and oral potentially malignant disorders...
April 2015: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/26044786/optimal-management-of-proliferative-verrucous-leukoplakia-a-systematic-review-of-the-literature
#19
REVIEW
Wesley M Abadie, Erin J Partington, Craig B Fowler, Cecelia E Schmalbach
OBJECTIVE: Proliferative verrucous leukoplakia (PVL) is a rare and recalcitrant form of leukoplakia. The purpose of this review is to further characterize the risk factors, clinical course, and optimal treatment for this highly aggressive, premalignant lesion. DATA SOURCES: Twenty-six articles on PVL with a total of 329 PVL cases. REVIEW METHODS: A systematic review of the literature using Ovid, PubMed, Cochrane Database, and gray literature was conducted of all PVL cases reported between 1985 and 2014...
October 2015: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/25737860/oral-verrucous-lesions-controversies-in-diagnosis-and-management
#20
D Mehrotra, M Goel, S Kumar, R Pandey, Hari Ram
AIMS: Oral verrucous lesions, typically presenting as slowly enlarging, grey or white, warty, exophytic overgrowths on the buccal mucosa or gingiva may be verrucous carcinoma (VC), verrucous hyperplasia (VH), proliferative verrucous leukoplakia (PVL), or may show the conventional invasive pattern of squamous cell carcinoma (SCC). This study was undertaken with the aim to report the demography of different types of oral verrucous lesions and evaluate their long-term outcome. MATERIAL & METHODS: This clinical study comprised 15 patients with verrucous lesions of the oral cavity who underwent biopsy for confirmation of diagnosis...
September 2012: Journal of Oral Biology and Craniofacial Research
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