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Proliferative verrucous leukoplakia

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https://www.readbyqxmd.com/read/29097794/oral-leukoplakia-and-proliferative-verrucous-leukoplakia-a-review-for-dental-practitioners
#1
K Staines, H Rogers
Objectives To provide an overview of the current thinking in terms of the diagnosis and management of oral leukoplakia and proliferative verrucous leukoplakia as relevant to general dental practitioners.Data sources, data selection, data extraction, data synthesis We searched the MEDLINE Ovid, EMBASE databases and the Cochrane Library, (1990 to 16 April 2017), restricting our search to English language with the following key words: leukoplakia, white patch, proliferative verrucous leukoplakia, precancerous lesion, premalignant lesions, potentially malignant oral conditions and potentially malignant oral disorders...
December 2017: British Dental Journal
https://www.readbyqxmd.com/read/28891106/treatment-resistance-in-potentially-malignant-disorders-nature-or-nurture-%C3%A2
#2
P J Thomson, M L Goodson, D R Smith
BACKGROUND: Contemporary potentially malignant disorder management is based upon provisional histological diagnosis followed by interventional surgery to excise or ablate 'high-risk' mucosal lesions. Although the majority of patients achieve disease-free status post-treatment, others develop further or persistent disease unresponsive to intervention. METHODS: A detailed, retrospective clinico-pathological review of treatment resistant potentially malignant lesions, from a 590 patient cohort treated by CO2 laser surgery and followed for a mean of 7...
September 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28814981/cpg-location-and-methylation-level-are-crucial-factors-for-the-early-detection-of-oral-squamous-cell-carcinoma-in-brushing-samples-using-bisulfite-sequencing-of-a-13-gene-panel
#3
Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini
BACKGROUND: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. The purpose of this study was to evaluate the diagnostic value of methylation level in a set of 18 genes by bisulfite next-generation sequencing...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28640498/management-of-proliferative-verrucous-leukoplakia-justification-for-a-conservative-approach
#4
Scott C Borgna, Peter T Clarke, Andrew G Schache, Derek Lowe, Michael W Ho, Caroline E McCarthy, Stephen Adair, E Anne Field, John K Field, Deborah Holt, Janet M Risk, Bijay P Rajlawat, Asterios Triantafyllou, Richard J Shaw
BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic. METHOD: Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Human papillomavirus (HPV) testing was undertaken on a subset...
October 2017: Head & Neck
https://www.readbyqxmd.com/read/28416237/proliferative-verrucous-leukoplakia-of-the-tongue
#5
Paolo Cariati, Ana Belen Marin Fernandez, Jose Fernandez Solis
No abstract text is available yet for this article.
April 14, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28209441/proliferative-verrucous-leukoplakia-diagnosis-management-and-current-advances
#6
Diogo Lenzi Capella, Jussara Maria Gonçalves, Adelino António Artur Abrantes, Liliane Janete Grando, Filipe Ivan Daniel
INTRODUCTION: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations. OBJECTIVE: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. METHODS: A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized...
September 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28160592/letter-to-the-editor-development-of-proliferative-verrucous-leukoplakia-pvl-in-oral-lichen-planus-is-it-not-a-clinical-spectrum-of-pvl
#7
D-T Fernandes, A-R Santos-Silva, P-A Vargas, M-A Lopes
No abstract text is available yet for this article.
March 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28060366/oral-lichenoid-lesions-distinguishing-the-benign-from-the-deadly
#8
Susan Müller
Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27900324/low-expression-of-angiotensinogen-and-dipeptidyl-peptidase-1-in-saliva-of-patients-with-proliferative-verrucous-leukoplakia
#9
Isadora Luana Flores, Alan Roger Santos-Silva, Ricardo Della Coletta, Adriana Franco Paes Leme, Marcio Ajudarte Lopes
AIM: To elucidate the profile of the salivary proteome. METHODS: Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests. RESULTS: A total of two hundred and eighty-three proteins were confidently identified in saliva...
November 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27891495/proliferative-verrucous-leukoplakia-a-perpetuating-ambiguity
#10
Monica Mehendiratta, Kanu Jain
No abstract text is available yet for this article.
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27866683/interventional-laser-surgery-for-oral-potentially-malignant-disorders-a-longitudinal-patient-cohort-study
#11
P J Thomson, M L Goodson, K Cocks, J E Turner
Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation risk. No clear management guidelines exist and it is unclear from the literature whether early diagnosis and intervention prevents cancer...
March 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27865210/exophytic-verrucous-hyperplasia-of-the-oral-cavity-%C3%A2-application-of-standardized-criteria-for-diagnosis-from-a-consensus-report
#12
Binti Zain Rosnah, George Kallarakkal Thomas, Ramanathan Anand, Kim Jin, Tilakaratne Wm, Takata Takashi, Warnakulasuriya Saman, Kumar Hazarey Vinay, Rich Alison, Mohd Hussaini Haizal, Jalil Ajura
Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Apart from virus-associated lesions, VPLs harboring malignant potential or behaviour such as verrucous carcinoma, proliferative verrucous leukoplakia, oral verrucous hyperplasia (OVH), oral papillary squamous cell carcinoma (PSCC) and oral conventional squamous cell carcinoma with papillary features (CSCC) need to be further clarified for better understanding of their predictable biologic behavior and appropriate treatment...
January 9, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27681951/cancer-associated-fibroblasts-are-an-infrequent-finding-in-the-microenvironment-of-proliferative-verrucous-leukoplakia-associated-squamous-cell-carcinoma
#13
Sharon J Akrish, Adi Rachmiel, Edmond Sabo, Marilena Vered, Ofer Ben-Izhak
BACKGROUND: Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca). METHODS: A retrospective clinicopathologic and immunohistochemical analysis of 97 tumor specimens from 78 patients (13 patients with proliferative verrucous leukoplakia-associated squamous cell carcinoma (n = 32) and conventional squamous cell carcinoma from the buccal mucosa, gingiva, and palate (n = 65) was conducted...
September 29, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27478070/a-proteomic-approach-to-compare-saliva-from-individuals-with-and-without-oral-leukoplakia
#14
Danielle Resende Camisasca, Lorena da Rós Gonçalves, Márcia Regina Soares, Vanessa Sandim, Fábio César Sousa Nogueira, Carlos Henrique Saraiva Garcia, Rodrigo Santana, Silvia Paula de Oliveira, Luisa Aguirre Buexm, Paulo Antônio Silvestre de Faria, Fernando Luiz Dias, Denise de Abreu Pereira, Russolina B Zingali, Gilda Alves, Simone Queiroz Chaves Lourenço
BACKGROUND: Oral leukoplakia is the most common potentially malignant disorder in the oral cavity and can precede carcinoma. This study aimed to identify possible oral leukoplakia salivary biomarkers. METHODS: Unstimulated saliva was collected from participants and protein concentration was determined. Proteins were then precipitated with cold acetone and separated using 2DE over a pH range of 3-10. Spot demarcation and matching were performed and protein identification was done through MS analysis...
January 16, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27461595/proliferative-verrucous-leukoplakia-an-update
#15
REVIEW
Anita Munde, Ravindra Karle
Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in elderly women, over 60 years at the time of diagnosis. The buccal mucosa and tongue are the most frequently involved sites...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27307679/diode-laser-in-treatment-of-recurrent-verrucous-leukoplakia
#16
Debanti Giri, Nitin Agarwal, Abhishek Sinha, Sunita Srivastava, Anuj Mishra
Laser first came into light in 1960 and had been used extensively in various fields of medicine. Laser has been experimented in the various dental field, and its utility is being recognized and established well in the dentistry. Lasers are widely used for a number of procedures such as cavity preparation, scaling, and root planning, surgical procedures like excision of soft tissue growths, etc., Improved healing, hemostasis, and sutureless excisions are some of the many advantages of laser over conventional treatment modalities...
April 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27031060/the-development-of-proliferative-verrucous-leukoplakia-in-oral-lichen-planus-a-preliminary-study
#17
M-J Garcia-Pola, S Llorente-Pendás, M González-Garcia, J-M García-Martín
BACKGROUND: Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus. MATERIAL AND METHODS: The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years. RESULTS: The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56...
May 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/26960457/the-role-of-ki-67-p16-cd34-bcl-2-cyclooxygenase-2-in-the-pathogenesis-of-proliferative-verrucous-leukoplakia
#18
A Thennavan, A A Byatnal, M C Solomon, R A Radhakrishnan
CONTEXT: Proliferative verrucous leukoplakia (PVL) is a highly persistent and aggressive oral pre-malignant lesion with an obscure etiopathogenesis and a malignant transformation rate of 85-100%. AIMS: The aim of the present study is to assess the role of Ki-67, p16, CD34, Bcl-2, cyclooxygenase-2 (COX-2) in the spectrum of PVL to ascertain their role in its etiopathogenesis. SETTINGS AND DESIGN: A retrospective chart analysis was carried out on a series of seven confirmed cases of PVL, which were followed-up for 2 years...
October 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26837785/the-lichenoid-tissue-reactions-of-the-oral-mucosa-oral-lichen-planus-and-other-lichenoid-lesions
#19
Susan Müller
Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions and can have varied etiologies. Immune-mediated disorders, including lichen planus, mucous membrane pemphigoid, discoid lupus erythematosus, and graft-versus-host disease, can have clinical and histologic overlaps. Lichenoid reactions to dental materials, such as amalgam, or to many systemic drugs are also well documented. Dysplasia of the oral cavity at times can also express a lichenoid histology, which may mask the potentially cancerous component...
December 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26832120/-proliferative-verrucous-leukoplakia-three-cases-and-literature-review
#20
REVIEW
A Ottavioli, F Campana, J-H Catherine, E Massereau, J Del Grande, U Ordioni
BACKGROUND: The aim of this study was to collect epidemiological, aetiopathogenic, clinical, histological and therapeutic data concerning proliferative verrucous leucoplakia (PVL) and to report three new cases. PATIENTS AND METHODS: A literature review performed using the Medline database enabled us to collate 39 studies involving 607 cases. Three new cases were added. RESULTS: PVL is a rare disease characterized by extensive and multifocal oral leucoplakic lesions...
March 2016: Annales de Dermatologie et de Vénéréologie
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