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https://www.readbyqxmd.com/read/28817419/the-association-of-fat-and-lean-tissue-with-whole-body-and-spine-bone-mineral-density-is-modified-by-hiv-status-and-sex-in-children-and-youth
#1
Denise L Jacobson, Jane C Lindsey, Brent A Coull, Kathleen Mulligan, Priya Bhagwat, Grace M Aldrovandi
BACKGROUND: HIV-infected (HIV-pos) male children/youth showed lower bone mineral density at sexual maturity than HIV-uninfected (HIV-neg) females. It is not known whether complications of HIV disease, including abnormal body fat distribution, contribute to lower bone accrual in male HIV-pos adolescents. METHODS: In a cross-sectional study, we evaluated the relationship between body composition (fat and lean mass) and bone mass in HIV-pos and HIV-neg children/youth and determined if it is modified by HIV status and sex...
August 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28801978/mindfulness-of-voices-self-compassion-and-secure-attachment-in-relation-to-the-experience-of-hearing-voices
#2
James Dudley, Catrin Eames, John Mulligan, Naomi Fisher
OBJECTIVES: Developing compassion towards oneself has been linked to improvement in many areas of psychological well-being, including psychosis. Furthermore, developing a non-judgemental, accepting way of relating to voices is associated with lower levels of distress for people who hear voices. These factors have also been associated with secure attachment. This study explores associations between the constructs of mindfulness of voices, self-compassion, and distress from hearing voices and how secure attachment style related to each of these variables...
August 12, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28794017/differential-recruitment-of-e3-ubiquitin-ligase-complexes-regulates-ret-isoform-internalization
#3
Brandy D Hyndman, Mathieu J F Crupi, Susan Peng, Leslie N Bone, Aisha N Rekab, Eric Y Lian, Simona M Wagner, Costin N Antonescu, Lois M Mulligan
The RET receptor tyrosine kinase is implicated in normal development and cancer. RET is expressed as two isoforms, RET9 and RET51, with unique C-terminal tail sequences that recruit distinct protein complexes to mediate signals. Upon activation, RET isoforms are internalized with distinct kinetics, suggesting differences in regulation. Here, we demonstrate that RET9 and RET51 differ in their abilities to recruit E3-ubiquitin ligases to their unique C-termini. RET51, but not RET9, interacts with, and is ubiquitinated by CBL, which is recruited through interactions with the GRB2 adaptor protein...
August 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28783501/high-risk-family-colorectal-cancer-screening-service-in-ireland-critical-review-of-clinical-outcomes
#4
Margaret Walshe, Robert Moran, Marie Boyle, Ion Cretu, Zita Galvin, Victoria Swan, Jason Trikovic, Michael P Farrell, Sinéad Foy, Loretta O'Brien, Jan Leyden, Niall Mulligan, Helen Fenlon, David J Gallagher, Padraic MacMathúna
BACKGROUND: We present the 15-year experience of a family colorectal cancer screening service in Ireland with emphasis on real life experience and outcomes. METHODS: Questionnaires were used to assess family cancer history and assign patients to risk categories; 'Moderate Risk', HNPCC, (suspected) genetic syndrome (non-HNPCC), 'Low Risk'. Screening was by full colonoscopy. We report neoplastic yield, examining effect of risk category, age, gender, and index colonoscopy findings...
August 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28779840/pinning-down-the-mechanism-of-transport-probing-the-structure-and-function-of-transporters-using-cysteine-cross-linking-and-site-specific-labeling
#5
Christopher Mulligan, Joseph A Mindell
Transporters are crucial in a number of cellular functions, including nutrient uptake, cell signaling, and toxin removal. As such, transporters are important drug targets and their malfunction is related to several disease states. Treating transporter-related diseases and developing pharmaceuticals targeting transporters require an understanding of their mechanism. Achieving a detailed understanding of transporter mechanism depends on an integrative approach involving structural and computational approaches as well as biochemical and biophysical methodologies...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28771053/recommendations-for-skin-cancer-monitoring-for-patients-with-chronic-lymphocytic-leukemia
#6
Anthea Mulcahy, Stephen P Mulligan, Stephen P Shumack
No abstract text is available yet for this article.
August 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28763731/natural-assurance-scheme-a-level-playing-field-framework-for-green-grey-infrastructure-development
#7
Benjamin Denjean, Mónica A Altamirano, Nina Graveline, Raffaele Giordano, Peter Van der Keur, David Moncoulon, Josh Weinberg, María Máñez Costa, Zdravko Kozinc, Mark Mulligan, Polona Pengal, John Matthews, Nora van Cauwenbergh, Elena López Gunn, David N Bresch
This paper proposes a conceptual framework to systematize the use of Nature-based solutions (NBS) by integrating their resilience potential into Natural Assurance Scheme (NAS), focusing on insurance value as corner stone for both awareness-raising and valuation. As such one of its core goal is to align research and pilot projects with infrastructure development constraints and priorities. Under NAS, the integrated contribution of natural infrastructure to Disaster Risk Reduction is valued in the context of an identified growing need for climate robust infrastructure...
July 29, 2017: Environmental Research
https://www.readbyqxmd.com/read/28761900/biphasic-zika-illness-with-rash-and-joint-pain
#8
Srilatha Edupuganti, Muktha S Natrajan, Nadine Rouphael, Lilin Lai, Yongxian Xu, Matthew Feldhammer, Charles Hill, Shital M Patel, Sara Jo Johnson, Mary Bower, Rodion Gorchakov, Rebecca Berry, Kristy O Murray, Mark J Mulligan
During the current Zika virus (ZIKV) outbreak, acute symptomatic ZIKV infection in adults appears to be a mild-to-moderate, self-limited illness. We present a case of ZIKV rash illness that improved and then relapsed without repeat exposure to ZIKV. Clinicians should be alert for relapses in patients with ZIKV infection.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28759094/conversion-of-sugar-to-fat-is-hepatic-de-novo-lipogenesis-leading-to-metabolic-syndrome-and-associated-chronic-diseases
#9
Jean-Marc Schwarz, Michael Clearfield, Kathleen Mulligan
Epidemiologic studies suggest a link between excess sugar consumption and obesity, fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus. One important pathway that may link these metabolic diseases to sugar consumption is hepatic conversion of sugar to fat, a process known as de novo lipogenesis (DNL). Mechanistic studies have shown that diets high in simple sugars increase both DNL and liver fat. Importantly, removal of sugar from diets of children with obesity for only 9 days consistently reduced DNL and liver fat and improved glucose and lipid metabolism...
August 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28757079/tracheal-diverticula-in-advanced-cystic-fibrosis-prevalence-features-and-outcomes-after-lung-transplantation
#10
Siddhartha G Kapnadak, Gregory A Kicska, Kathleen J Ramos, Desiree A Marshall, Tamara Y Carroll, Sudhakar N Pipavath, Michael S Mulligan, Christopher H Goss, Moira L Aitken
BACKGROUND: Tracheal diverticula (TD) are rare anomalies that may harbor infected secretions, posing potential risk to patients with lung disease. In an end-stage cystic fibrosis (CF) cohort, we describe the characteristics and associated post-lung transplant (LTx) outcomes of TD. METHODS: Pre-transplant computed tomography (CT)'s were reviewed in CF patients undergoing LTx. TD were characterized radiographically and on autopsy when available. Pre-transplant clinical variables and post-transplant outcomes were compared by TD status...
July 27, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28751453/maternal-modifiers-of-the-infant-gut-microbiota-metabolic-consequences
#11
Christopher M Mulligan, Jacob E Friedman
Transmission of metabolic diseases from mother to child is multifactorial and includes genetic, epigenetic, and environmental influences. Evidence in rodents, humans and non-human primates support the scientific premise that exposure to maternal obesity or high-fat diet during pregnancy creates a long-lasting metabolic signature on the infant innate immune system and the juvenile microbiota which predisposes the offspring to obesity and metabolic diseases. In neonates, gastrointestinal microbes introduced through the mother are noted for their ability to serve as direct inducers/regulators of the infant immune system...
July 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28750854/tularemia-vaccine-safety-reactogenicity-take-skin-reactions-and-antibody-responses-following-vaccination-with-a-new-lot-of-the-francisella-tularensis-live-vaccine-strain-a-phase-2-randomized-clinical-trial
#12
Mark J Mulligan, Jack T Stapleton, Wendy A Keitel, Sharon E Frey, Wilbur H Chen, Nadine Rouphael, Srilatha Edupuganti, Allison Beck, Patricia L Winokur, Hana M El Sahly, Shital M Patel, Robert L Atmar, Irene Graham, Edwin Anderson, Samer S El-Kamary, Marcela F Pasetti, Marcelo B Sztein, Heather Hill, Johannes B Goll
BACKGROUND: Tularemia is caused by Francisella tularensis, a gram-negative bacterium that has been weaponized as an aerosol. For protection of personnel conducting biodefense research, the United States Army required clinical evaluation of a new lot of tularemia live vaccine strain manufactured in accordance with Current Good Manufacturing Practices. METHODS: A phase 2 randomized clinical trial compared the new lot (DVC-LVS) to the existing vaccine that has been in use for decades (USAMRIID-LVS)...
July 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28720169/characteristics-of-healthy-older-adults-that-influence-self-rated-cognitive-function
#13
Bryce P Mulligan, Colette M Smart, Sidney J Segalowitz, Stuart W S MacDonald
OBJECTIVES: We sought to clarify the nature of self-reported cognitive function among healthy older adults by considering the short-term, within-person association (coupling) of subjective cognitive function with objective cognitive performance. We expected this within-person coupling to differ between persons as a function of self-perceived global cognitive decline and depression, anxiety, or neuroticism. METHODS: This was an intensive measurement (short-term longitudinal) study of 29 older adult volunteers between the ages of 65 and 80 years without an existing diagnosis of dementia or mild cognitive impairment...
July 19, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28713554/growth-hormone-receptor-antagonism-with-pegvisomant-in-insulin-resistant-non-diabetic-men-a-phase-ii-pilot-study
#14
Ada P Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J Murphy, Ethan J Weiss
Background: Growth hormone (GH) is known to affect insulin and glucose metabolism.  Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men.  Methods: Four men between the ages of 18-62 with a BMI of 18-35kg/m (2), with insulin resistance as defined by a HOMA-IR > 2.77, were treated for four weeks with pegvisomant 20 mg daily...
2017: F1000Research
https://www.readbyqxmd.com/read/28706065/global-analysis-of-protein-folding-using-massively-parallel-design-synthesis-and-testing
#15
Gabriel J Rocklin, Tamuka M Chidyausiku, Inna Goreshnik, Alex Ford, Scott Houliston, Alexander Lemak, Lauren Carter, Rashmi Ravichandran, Vikram K Mulligan, Aaron Chevalier, Cheryl H Arrowsmith, David Baker
Proteins fold into unique native structures stabilized by thousands of weak interactions that collectively overcome the entropic cost of folding. Although these forces are "encoded" in the thousands of known protein structures, "decoding" them is challenging because of the complexity of natural proteins that have evolved for function, not stability. We combined computational protein design, next-generation gene synthesis, and a high-throughput protease susceptibility assay to measure folding and stability for more than 15,000 de novo designed miniproteins, 1000 natural proteins, 10,000 point mutants, and 30,000 negative control sequences...
July 14, 2017: Science
https://www.readbyqxmd.com/read/28702470/pericarditis-associated-with-acute-zika-virus-infection-in-a-returning-traveler
#16
Jesse J Waggoner, Nadine Rouphael, Yongxian Xu, Muktha Natrajan, Lilin Lai, Shital M Patel, Rebeca D Levit, Srilatha Edupuganti, Mark J Mulligan
Despite the widespread outbreak, few cases of Zika virus associated with cardiac manifestations have been described. We present a case of pericarditis in the setting of an acute, symptomatic Zika virus infection in a traveler returning from St. Thomas. Clinicians should be alert for this potential complication of Zika virus infection.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28698189/a-comprehensive-review-on-men-2b
#17
Frederic Castinetti, Jeff Moley, Lois M Mulligan, Steven G Waguespack
MEN2B is a very rare autosomal dominant hereditary tumor syndrome associated with medullary thyroid carcinoma (MTC) in 100% cases, pheochromocytoma in 50% cases, and multiple extra-endocrine features, many of which can be quite disabling. Only few data are available in the literature. The aim of this review is to try to give further insights into the natural history of the disease and to point out the missing evidence that would help clinicians optimize the management of such patients. MEN2B is mainly characterized by the early occurrence of MTC, which led the American Thyroid Association to recommend preventive thyroidectomy before the age of 1...
July 11, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28681381/epilepsy-transition-from-pediatric-to-adult-care-recommendations-of-the-ontario-epilepsy-implementation-task-force
#18
REVIEW
Danielle M Andrade, Anne S Bassett, Eduard Bercovici, Felippe Borlot, Esther Bui, Peter Camfield, Guida Quaglia Clozza, Eyal Cohen, Timothy Gofine, Lisa Graves, Jon Greenaway, Beverly Guttman, Maya Guttman-Slater, Ayman Hassan, Megan Henze, Miriam Kaufman, Bernard Lawless, Hannah Lee, Lezlee Lindzon, Lysa Boissé Lomax, Mary Pat McAndrews, Dolly Menna-Dack, Berge A Minassian, Janice Mulligan, Rima Nabbout, Tracy Nejm, Mary Secco, Laurene Sellers, Michelle Shapiro, Marie Slegr, Rosie Smith, Peter Szatmari, Leeping Tao, Anastasia Vogt, Sharon Whiting, O Carter Snead
The transition from a pediatric to adult health care system is challenging for many youths with epilepsy and their families. Recently, the Ministry of Health and Long-Term Care of the Province of Ontario, Canada, created a transition working group (TWG) to develop recommendations for the transition process for patients with epilepsy in the Province of Ontario. Herein we present an executive summary of this work. The TWG was composed of a multidisciplinary group of pediatric and adult epileptologists, psychiatrists, and family doctors from academia and from the community; neurologists from the community; nurses and social workers from pediatric and adult epilepsy programs; adolescent medicine physician specialists; a team of physicians, nurses, and social workers dedicated to patients with complex care needs; a lawyer; an occupational therapist; representatives from community epilepsy agencies; patients with epilepsy; parents of patients with epilepsy and severe intellectual disability; and project managers...
July 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28680507/bndf-methylation-in-mothers-and-newborns-is-associated-with-maternal-exposure-to-war-trauma
#19
Darlene A Kertes, Samarth S Bhatt, Hayley S Kamin, David A Hughes, Nicole C Rodney, Connie J Mulligan
BACKGROUND: The BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critical roles throughout the body and is essential for placental and fetal development. Rodent studies show that early life stress, including prenatal stress, broadly alters BDNF methylation, with presumed changes in gene expression. No studies have assessed prenatal exposure to maternal traumatic stress and BDNF methylation in humans...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28677942/effect-of-fibular-repositioning-taping-in-adult-basketball-players-with-chronic-ankle-instability-a-randomized-placebo-controlled-crossover-trial
#20
Yanina Alves, Fernando Ribeiro, Anabela G Silva
BACKGROUND: Chronic ankle instability presents a high incidence and prevalence in basketbal players. It's important to develop strategies to reduce the functional and mechanical limitations resulting from this condition. To compare the effect of Mulligan ́s fibular repositioning taping with a placebo taping immediatly after application and after a running test (Yo-Yo IRT). METHODS: 16 adult basketball players (10 male, 6 female) with chronic ankle instability and mean age 21...
July 5, 2017: Journal of Sports Medicine and Physical Fitness
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