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https://www.readbyqxmd.com/read/28217956/child-with-radiologically-recurrent-thalamic-tumor
#1
Tafadzwa Mandiwanza, Chandrasekaran Kaliaperumal, Linda Mulligan, Elizabeth Ryan, Seamus Looby, John Caird, Francesca Brett
No abstract text is available yet for this article.
March 2017: Brain Pathology
https://www.readbyqxmd.com/read/28217921/winners-of-the-2016-american-college-of-rheumatology-annual-image-competition
#2
Miles Mulligan, Brian Keroack
No abstract text is available yet for this article.
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28217426/treatment-of-anterior-shoulder-subluxation-using-the-mulligan-concept-and-reflex-neuromuscular-stabilization-a-case-report
#3
Robinetta A Hudson, Russell T Baker, Alan Nasypany, Don Reordan
BACKGROUND AND PURPOSE: Shoulder instability, a common issue among athletes who engage in contact sports, may lead to recurrent subluxations, or partial dislocations of the shoulder. Young athletic patients generally respond poorly to the nonsurgical treatments for shoulder instability that are commonly utilized. The purpose of this case report is to describe the effects of the treatment guided by the Mulligan Concept (MC) coupled with reflex neuromuscular stabilization (RNS) also known as reactive neuromuscular training (RNT), on an adolescent football player with glenohumeral joint (GHJ) instability who sustained a traumatic anterior subluxation...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28212159/liver-allocation-and-distribution-time-for-a-change
#4
Ranjit Deshpande, Ryutaro Hirose, David Mulligan
PURPOSE OF REVIEW: Liver allograft allocation has been a topic of hot debate for over a decade. New redistricting changes have been proposed by the Liver and Intestinal Transplant Committee to the existing United Network for Organ Sharing (UNOS) liver allocation policy. The basis of this new proposal is similar to the old one with an aim to distribute organs in a fair, efficient and equitable fashion. In this review, we plan to look in depth at the redistribution proposals thus far, their merits and how they may help patients who do not have adequate access to livers...
February 15, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28207639/predictors-of-waitlist-mortality-in-portopulmonary-hypertension
#5
Hilary M DuBrock, David S Goldberg, Norman L Sussman, Sonja D Bartolome, Zakiyah Kadry, Reena J Salgia, David C Mulligan, Walter K Kremers, Steven M Kawut, Michael J Krowka, Richard N Channick
BACKGROUND: The current Organ Procurement Transplantation Network (OPTN) policy grants Model for End Stage Liver Disease (MELD) exception points to patients with portopulmonary hypertension (POPH), but potentially important factors, such as severity of liver disease and pulmonary hypertension, are not included in the exception score, and may affect survival. The purpose of this study was to identify significant predictors of waitlist mortality in patients with POPH. METHODS: We performed a retrospective cohort study of patients in the OPTN database with hemodynamics consistent with POPH [defined as mean pulmonary arterial pressure (mPAP) >25mmHg and pulmonary vascular resistance (PVR) ≥240 dynes-s-cm] who were approved for a POPH MELD exception between 2006 and 2014...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28199679/higher-t-cell-responses-induced-by-dna-rad5-hiv-1-preventive-vaccine-are-associated-with-lower-hiv-1-infection-risk-in-an-efficacy-trial
#6
Holly E Janes, Kristen W Cohen, Nicole Frahm, Stephen C De Rosa, Brittany Sanchez, John Hural, Craig A Magaret, Shelly Karuna, Carter Bentley, Raphael Gottardo, Greg Finak, Douglas Grove, Mingchao Shen, Barney S Graham, Richard A Koup, Mark J Mulligan, Beryl Koblin, Susan P Buchbinder, Michael C Keefer, Elizabeth Adams, Chuka Anude, Lawrence Corey, Magdalena Sobieszczyk, Scott M Hammer, Peter B Gilbert, M Juliana McElrath
No abstract text is available yet for this article.
February 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28169568/the-influence-of-age-sex-and-body-mass-index-on-the-effectiveness-of-brisk-walking-for-obesity-management-in-adults-a-systematic-review-and-meta-analysis
#7
Leon Mabire, Ramakrishnan Mani, Lizhou Liu, Hilda Mulligan, David Baxter
BACKGROUND: Brisk walking is the most popular activity for obesity management for adults. We aimed to identify whether participant age, sex and body mass index (BMI) influenced the effectiveness of brisk walking. METHODS: A search of nine databases was conducted for randomized controlled trials (RCTs). Two investigators selected RCTs reporting on change in body weight, BMI, waist circumference, fat mass, fat-free mass, and body fat percentage following a brisk walking intervention in obese adults...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28157216/ibrutinib-in-previously-treated-chronic-lymphocytic-leukemia-patients-with-autoimmune-cytopenias-in-the-resonate-study
#8
M Montillo, S O'Brien, A Tedeschi, J C Byrd, C Dearden, D Gill, J R Brown, J C Barrientos, S P Mulligan, R R Furman, F Cymbalista, C Plascencia, S Chang, E Hsu, D F James, P Hillmen
No abstract text is available yet for this article.
February 3, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28130182/induction-of-cftr-gene-expression-by-1-25-oh-2-vitamin-d3-25oh-vitamin-d3-and-vitamin-d3-in-cultured-human-airway-epithelial-cells-and-in-mouse-airways
#9
Kristina M DiFranco, Jennifer K Mulligan, Aman S Sumal, Gill Diamond
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which often leads to protein misfolding and no CFTR surface localization. This then leads to chronic airway infections, inflammation, and tissue damage. Although vitamin D has been explored as a therapy to treat CF due to its antimicrobial-inducing and anti-inflammatory properties, the effect of 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3) on CFTR directly has not been studied...
January 24, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28121987/genetic-variation-in-the-social-environment-contributes-to-health-and-disease
#10
Amelie Baud, Megan K Mulligan, Francesco Paolo Casale, Jesse F Ingels, Casey J Bohl, Jacques Callebert, Jean-Marie Launay, Jon Krohn, Andres Legarra, Robert W Williams, Oliver Stegle
Assessing the impact of the social environment on health and disease is challenging. As social effects are in part determined by the genetic makeup of social partners, they can be studied from associations between genotypes of one individual and phenotype of another (social genetic effects, SGE, also called indirect genetic effects). For the first time we quantified the contribution of SGE to more than 100 organismal phenotypes and genome-wide gene expression measured in laboratory mice. We find that genetic variation in cage mates (i...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28121290/a-general-method-for-determining-secondary-active-transporter-substrate-stoichiometry
#11
Gabriel A Fitzgerald, Christopher Mulligan, Joseph A Mindell
The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter's mechanism. Stoichiometry is known for a wide array of mammalian transporters, but, due to a lack of readily available tools, not for most of the prokaryotic transporters for which high-resolution structures are available. Here, we describe a general method for using radiolabeled substrate flux assays to determine coupling stoichiometries of electrogenic secondary active transporters reconstituted in proteoliposomes by measuring transporter equilibrium potentials...
January 25, 2017: ELife
https://www.readbyqxmd.com/read/28113023/reply-to-l-casadaban-et-al
#12
Donna Niedzwiecki, Wendy L Frankel, Alan P Venook, Xing Ye, Paula N Friedman, Richard M Goldberg, Robert J Mayer, Thomas A Colacchio, Jude Marie Mulligan, Timothy S Davison, Eamonn O'Brien, Peter Kerr, Patrick G Johnston, Richard D Kennedy, D Paul Harkin, Richard L Schilsky, Monica M Bertagnolli, Robert S Warren, Federico Innocenti
No abstract text is available yet for this article.
January 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28106458/nonsupersymmetric-dualities-from-mirror-symmetry
#13
Shamit Kachru, Michael Mulligan, Gonzalo Torroba, Huajia Wang
We study supersymmetry breaking perturbations of the simplest dual pair of (2+1)-dimensional N=2 supersymmetric field theories-the free chiral multiplet and N=2 super QED with a single flavor. We find dual descriptions of a phase diagram containing four distinct massive phases. The equivalence of the intervening critical theories gives rise to several nonsupersymmetric avatars of mirror symmetry: we find dualities relating scalar QED to a free fermion and Wilson-Fisher theories to both scalar and fermionic QED...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28101962/the-peopling-of-the-americas-and-the-origin-of-the-beringian-occupation-model
#14
Connie J Mulligan, Emőke J E Szathmáry
The current model for peopling of the Americas involves divergence from an ancestral Asian population followed by a period of population isolation and genetic diversification in Beringia, and finally, a rapid expansion into and throughout the Americas. Studies in the 1970s sought to characterize the biological relationships between different indigenous populations and first proposed an occupation of Beringia. More recent studies using molecular genetic markers often neglect to reference early works that laid the groundwork for current colonization models...
March 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28095256/evaluation-of-a-psychomotor-vigilance-task-for-touch-screen-devices
#15
Lucia Arsintescu, Jeffrey B Mulligan, Erin E Flynn-Evans
OBJECTIVE: Our goals were to compare three techniques for performing a psychomotor vigilance task (PVT) on a touch screen device (fifth-generation iPod) and to determine the device latency. BACKGROUND: The PVT is a reaction-time test that is sensitive to sleep loss and circadian misalignment. Several PVT tests have been developed for touch screen devices, but unlike the standard PVT developed for laboratory use, these tests allow for touch responses to be recorded at any location on the device, with contact from any finger...
January 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28088430/flipping-the-classroom-case-based-learning-accountability-assessment-and-feedback-leads-to-a-favorable-change-in-culture
#16
Nahush A Mokadam, Todd F Dardas, Joshua L Hermsen, Jay D Pal, Michael S Mulligan, L Myria Jacobs, Douglas E Wood, Edward D Verrier
OBJECTIVE: The 88-week Thoracic Surgery Curriculum is challenging to implement because of the large content in a traditional lecture format. This study investigates flipping the classroom by using a case-based format designed to stimulate resident preparation and engagement. METHODS: The didactic conference format was altered. Curricular reading assignments, case review, and conference participation prepared residents for novel formative assessment quizzes. Ten residents participated, and faculty served as controls...
December 19, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28058793/effects-of-selection-for-ethanol-preference-on-gene-expression-in-the-nucleus-accumbens-of-hs-cc-mice
#17
A M Colville, O D Iancu, D L Oberbeck, P Darakjian, C L Zheng, N A R Walter, C A Harrington, R P Searles, S McWeeney, R J Hitzemann
Previous studies on changes in murine brain gene expression associated with the selection for ethanol preference have used F2 intercross or heterogeneous stock (HS) founders, derived from standard laboratory strains. However, these populations represent only a small proportion of the genetic variance available in Mus musculus. To investigate a wider range of genetic diversity, we selected mice for ethanol preference using an HS derived from the eight strains of the collaborative cross. These HS mice were selectively bred (four generations) for high and low ethanol preference...
January 6, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28038352/effects-of-decreased-dopamine-transporter-levels-on-nigrostriatal-neurons-and-paraquat-maneb-toxicity-in-mice
#18
Franziska Richter, Lauryn Gabby, Kimberly A McDowell, Caitlyn K Mulligan, Krystal De La Rosa, Pedrom C Sioshansi, Farzad Mortazavi, Ingrid Cely, Larry C Ackerson, Linda Tsan, Niall P Murphy, Nigel T Maidment, Marie-Françoise Chesselet
How genetic variations in the dopamine transporter (DAT) combined with exposure to environmental toxins modulate the risk of Parkinson's disease remains unclear. Using unbiased stereology in DAT knock-down mice (DAT-KD) and wild-type (WT) littermates, we found that decreased DAT caused a loss of tyrosine hydroxylase-positive (dopaminergic) neurons in subregions of the substantia nigra pars compacta at 3-4 days, 5 weeks, and 18 months of age. Both genotypes lost dopaminergic neurons with age and remaining neurons at 11 months were resilient to paraquat/maneb...
March 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28027852/analyses-of-differentially-expressed-genes-after-exposure-to-acute-stress-acute-ethanol-or-a-combination-of-both-in-mice
#19
Jessica A Baker, Jingxin Li, Diana Zhou, Ming Yang, Melloni N Cook, Byron C Jones, Megan K Mulligan, Kristin M Hamre, Lu Lu
Alcohol abuse is a complex disorder, which is confounded by other factors, including stress. In the present study, we examined gene expression in the hippocampus of BXD recombinant inbred mice after exposure to ethanol (NOE), stress (RSS), and the combination of both (RSE). Mice were given an intraperitoneal (i.p.) injection of 1.8 g/kg ethanol or saline, and subsets of both groups were exposed to acute restraint stress for 15 min or controls. Gene expression in the hippocampus was examined using microarray analysis...
February 2017: Alcohol
https://www.readbyqxmd.com/read/28013265/decline-in-bone-mass-with-tenofovir-disoproxil-fumarate-emtricitabine-is-associated-with-hormonal-changes-in-the-absence-of-renal-impairment-when-used-by-hiv-uninfected-adolescent-boys-and-young-men-for-hiv-preexposure-prophylaxis
#20
Peter L Havens, Charles B Stephensen, Marta D Van Loan, Gertrud U Schuster, Leslie R Woodhouse, Patricia M Flynn, Catherine M Gordon, Cynthia G Pan, Brandy Rutledge, Nancy Liu, Craig M Wilson, Rohan Hazra, Sybil G Hosek, Peter L Anderson, Sharon M Seifert, Bill G Kapogiannis, Kathleen Mulligan
BACKGROUND: We aimed to define the relative importance of renal and endocrine changes in tenofovir disoproxil fumarate (TDF)-related bone toxicity. METHODS: In a study of daily TDF/emtricitabine (FTC) preexposure prophylaxis (PrEP) in human immunodeficiency virus (HIV)-uninfected young men who have sex with men, we measured changes from baseline in blood and urine markers of the parathyroid hormone (PTH)-vitamin D-fibroblast growth factor 23 (FGF23) axis, creatinine, and renal tubular reabsorption of phosphate (TRP)...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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