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https://www.readbyqxmd.com/read/28327164/international-consultation-on-long-term-global-health-research-priorities-research-capacity-and-research-uptake-in-developing-countries
#1
David Mc Conalogue, Sue Kinn, Jo-Ann Mulligan, Malcolm McNeil
BACKGROUND: In recognition of the need for long-term planning for global health research, and to inform future global health research priorities, the United Kingdom Department for International Development (DfID) carried out a public consultation between May and June 2015. The consultation aimed to elicit views on the (1) the long-term future global health research priorities; (2) areas likely to be less important over time; (3) how to improve research uptake in low-income countries; and (4) how to build research capacity in low-income countries...
March 21, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28325082/-i-do-like-the-activities-which-i-can-do%C3%A2-leisure-participation-experiences-of-children-with-movement-impairments
#2
Parimala S Kanagasabai, Hilda Mulligan, Leigh A Hale, Brigit Mirfin-Veitch
AIM: To explore in depth the leisure participation experiences of children with movement impairments. METHODS: We used Interpretative Phenomenological Analysis approach to interpret and understand the experiences of 22 children with movement impairments, aged between 6 and 12 years. Children expressed their views through flexible child-centred methods of data collection that allowed the children to draw, paint, use stickers, and demonstrate their leisure activities and equipment while communicating about their experiences...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28306182/barriers-and-enablers-of-type-2-diabetes-self-management-in-people-with-severe-mental-illness
#3
Kathleen Mulligan, Hayley McBain, Frederique Lamontagne-Godwin, Jacqui Chapman, Mark Haddad, Julia Jones, Chris Flood, David Thomas, Alan Simpson
BACKGROUND: People with diabetes and severe mental illness (SMI) experience poorer outcomes than those with diabetes alone. To improve outcomes, it is necessary to understand the difficulties that people with SMI experience in managing their diabetes. AIMS: To identify barriers and enablers to effective diabetes self-management experienced by people with SMI and type 2 diabetes. METHOD: Qualitative methodology using semi-structured interviews was employed...
March 17, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28301980/an-investigation-of-intra-individual-variability-in-children-with-fetal-alcohol-spectrum-disorder-fasd
#4
Sheliza Ali, Kimberly A Kerns, Bryce P Mulligan, Heather Carmichael Olson, Susan J Astley
Intra-individual variability (IIV) is defined as systematic within-person variation in performance either across test sessions (e.g., test/retest performance on the same task) or in one session (e.g., variations in performance on multiple trials of a single task). Higher levels of IIV have been noted as a characteristic of neurodevelopmental disorders such as attention deficit/hyperactivity disorder​ (ADHD), but IIV is yet to be investigated in fetal alcohol spectrum disorder (FASD). FASD is a term used to describe a range of conditions resulting from prenatal exposure to alcohol...
March 16, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28296577/genome-wide-identification-and-characterization-of-small-rnas-in-rhodobacter-capsulatus-and-identification-of-small-rnas-affected-by-loss-of-the-response-regulator-ctra
#5
Marc P Grüll, Lourdes Peña-Castillo, Martin E Mulligan, Andrew S Lang
Small non-coding RNAs (sRNAs) are involved in the control of numerous cellular processes through various regulatory mechanisms, and in the past decade many studies have identified sRNAs in a multitude of bacterial species using RNA sequencing (RNA-seq). Here, we present the first genome-wide analysis of sRNA sequencing data in Rhodobacter capsulatus, a purple nonsulfur photosynthetic alphaproteobacterium. Using a recently developed bioinformatics approach, sRNA-Detect, we detected 422 putative sRNAs from R...
March 15, 2017: RNA Biology
https://www.readbyqxmd.com/read/28295171/successful-use-of-bruton-s-kinase-inhibitor-ibrutinib-to-control-paraneoplastic-pemphigus-in-a-patient-with-paraneoplastic-autoimmune-multiorgan-syndrome-and-chronic-lymphocytic-leukaemia
#6
Andrew Lee, Suneet Sandhu, Louise Imlay-Gillespie, Stephen Mulligan, Stephen Shumack
We present the case of a 51-year-old man who developed paraneoplastic pemphigus (PNP) in the context of chronic lymphocytic leukemia (CLL). His CLL was successfully controlled with ibrutinib. Concurrently, there was significant improvement of his PNP, suggesting that ibrutinib may be a very useful addition to the treatment options in this potentially life-threatening autoimmune disorder.
March 13, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28285363/not-all-identification-tasks-are-born-equal-testing-the-involvement-of-production-processes-in-perceptual-identification-and-lexical-decision
#7
Pietro Spataro, Daniele Saraulli, Neil W Mulligan, Vincenzo Cestari, Marco Costanzi, Clelia Rossi-Arnaud
The distinction between identification and production processes suggests that implicit memory should require more attention resources when there is a competition between alternative solutions during the test phase. The present two experiments assessed this hypothesis by examining the effects of divided attention (DA) at encoding on the high- and low-response-competition versions of perceptual identification (Experiment 1) and lexical decision (Experiment 2). In both experiments, words presented in the high-response-competition condition had many orthographic neighbours and at least one higher-frequency neighbour, whereas words presented in the low-response-competition condition had few orthographic neighbours and no higher-frequency neighbour...
March 11, 2017: Psychological Research
https://www.readbyqxmd.com/read/28277568/neurodevelopmental-perspectives-on-wnt-signaling-in-psychiatry
#8
REVIEW
Kimberly A Mulligan, Benjamin N R Cheyette
Mounting evidence indicates that Wnt signaling is relevant to pathophysiology of diverse mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In the 35 years since Wnt ligands were first described, animal studies have richly explored how downstream Wnt signaling pathways affect an array of neurodevelopmental processes and how their disruption can lead to both neurological and behavioral phenotypes. Recently, human induced pluripotent stem cell (hiPSC) models have begun to contribute to this literature while pushing it in increasingly translational directions...
February 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/28271010/measurement-of-dynamic-cell-induced-3d-displacement-fields-in-vitro-for-traction-force-optical-coherence-microscopy
#9
Jeffrey A Mulligan, François Bordeleau, Cynthia A Reinhart-King, Steven G Adie
Traction force microscopy (TFM) is a method used to study the forces exerted by cells as they sense and interact with their environment. Cell forces play a role in processes that take place over a wide range of spatiotemporal scales, and so it is desirable that TFM makes use of imaging modalities that can effectively capture the dynamics associated with these processes. To date, confocal microscopy has been the imaging modality of choice to perform TFM in 3D settings, although multiple factors limit its spatiotemporal coverage...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28256358/safety-and-immunogenicity-of-a-modified-vaccinia-ankara-vaccine-using-three-immunization-schedules-and-two-modes-of-delivery-a-randomized-clinical-non-inferiority-trial
#10
Lisa A Jackson, Sharon E Frey, Hana M El Sahly, Mark J Mulligan, Patricia L Winokur, Karen L Kotloff, James D Campbell, Robert L Atmar, Irene Graham, Evan J Anderson, Edwin L Anderson, Shital M Patel, Colin Fields, Wendy Keitel, Nadine Rouphael, Heather Hill, Johannes B Goll
INTRODUCTION: To guide the use of modified vaccinia Ankara (MVA) vaccine in response to a release of smallpox virus, the immunogenicity and safety of shorter vaccination intervals, and administration by jet injector (JI), were compared to the standard schedule of administration on Days 1 and 29 by syringe and needle (S&N). METHODS: Healthy adults 18-40years of age were randomly assigned to receive MVA vaccine subcutaneously by S&N on Days 1 and 29 (standard), Days 1 and 15, or Days 1 and 22, or to receive the vaccine subcutaneously by JI on Days 1 and 29...
February 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28253470/public-access-defibrillation-emerging-importance-of-automated-external-defibrillators-as-a-diagnostic-clinical-tool
#11
Andrew D Mulligan, Omar Al-Mukhtar, Michael Wong
No abstract text is available yet for this article.
March 6, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28217956/child-with-radiologically-recurrent-thalamic-tumor
#12
Tafadzwa Mandiwanza, Chandrasekaran Kaliaperumal, Linda Mulligan, Elizabeth Ryan, Seamus Looby, John Caird, Francesca Brett
No abstract text is available yet for this article.
March 2017: Brain Pathology
https://www.readbyqxmd.com/read/28217921/winners-of-the-2016-american-college-of-rheumatology-annual-image-competition
#13
Miles Mulligan, Brian Keroack
No abstract text is available yet for this article.
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28217426/treatment-of-anterior-shoulder-subluxation-using-the-mulligan-concept-and-reflex-neuromuscular-stabilization-a-case-report
#14
Robinetta A Hudson, Russell T Baker, Alan Nasypany, Don Reordan
BACKGROUND AND PURPOSE: Shoulder instability, a common issue among athletes who engage in contact sports, may lead to recurrent subluxations, or partial dislocations of the shoulder. Young athletic patients generally respond poorly to the nonsurgical treatments for shoulder instability that are commonly utilized. The purpose of this case report is to describe the effects of the treatment guided by the Mulligan Concept (MC) coupled with reflex neuromuscular stabilization (RNS) also known as reactive neuromuscular training (RNT), on an adolescent football player with glenohumeral joint (GHJ) instability who sustained a traumatic anterior subluxation...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28212159/liver-allocation-and-distribution-time-for-a-change
#15
Ranjit Deshpande, Ryutaro Hirose, David Mulligan
PURPOSE OF REVIEW: Liver allograft allocation has been a topic of hot debate for over a decade. New redistricting changes have been proposed by the Liver and Intestinal Transplant Committee to the existing United Network for Organ Sharing (UNOS) liver allocation policy. The basis of this new proposal is similar to the old one with an aim to distribute organs in a fair, efficient and equitable fashion. In this review, we plan to look in depth at the redistribution proposals thus far, their merits and how they may help patients who do not have adequate access to livers...
February 15, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28207639/predictors-of-waitlist-mortality-in-portopulmonary-hypertension
#16
Hilary M DuBrock, David S Goldberg, Norman L Sussman, Sonja D Bartolome, Zakiyah Kadry, Reena J Salgia, David C Mulligan, Walter K Kremers, Steven M Kawut, Michael J Krowka, Richard N Channick
BACKGROUND: The current Organ Procurement Transplantation Network (OPTN) policy grants Model for End Stage Liver Disease (MELD) exception points to patients with portopulmonary hypertension (POPH), but potentially important factors, such as severity of liver disease and pulmonary hypertension, are not included in the exception score, and may affect survival. The purpose of this study was to identify significant predictors of waitlist mortality in patients with POPH. METHODS: We performed a retrospective cohort study of patients in the OPTN database with hemodynamics consistent with POPH [defined as mean pulmonary arterial pressure (mPAP) >25mmHg and pulmonary vascular resistance (PVR) ≥240 dynes-s-cm] who were approved for a POPH MELD exception between 2006 and 2014...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28199679/higher-t-cell-responses-induced-by-dna-rad5-hiv-1-preventive-vaccine-are-associated-with-lower-hiv-1-infection-risk-in-an-efficacy-trial
#17
Holly E Janes, Kristen W Cohen, Nicole Frahm, Stephen C De Rosa, Brittany Sanchez, John Hural, Craig A Magaret, Shelly Karuna, Carter Bentley, Raphael Gottardo, Greg Finak, Douglas Grove, Mingchao Shen, Barney S Graham, Richard A Koup, Mark J Mulligan, Beryl Koblin, Susan P Buchbinder, Michael C Keefer, Elizabeth Adams, Chuka Anude, Lawrence Corey, Magdalena Sobieszczyk, Scott M Hammer, Peter B Gilbert, M Juliana McElrath
No abstract text is available yet for this article.
February 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28169568/the-influence-of-age-sex-and-body-mass-index-on-the-effectiveness-of-brisk-walking-for-obesity-management-in-adults-a-systematic-review-and-meta-analysis
#18
Leon Mabire, Ramakrishnan Mani, Lizhou Liu, Hilda Mulligan, David Baxter
BACKGROUND: Brisk walking is the most popular activity for obesity management for adults. We aimed to identify whether participant age, sex and body mass index (BMI) influenced the effectiveness of brisk walking. METHODS: A search of nine databases was conducted for randomized controlled trials (RCTs). Two investigators selected RCTs reporting on change in body weight, BMI, waist circumference, fat mass, fat-free mass, and body fat percentage following a brisk walking intervention in obese adults...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28157216/ibrutinib-in-previously-treated-chronic-lymphocytic-leukemia-patients-with-autoimmune-cytopenias-in-the-resonate-study
#19
M Montillo, S O'Brien, A Tedeschi, J C Byrd, C Dearden, D Gill, J R Brown, J C Barrientos, S P Mulligan, R R Furman, F Cymbalista, C Plascencia, S Chang, E Hsu, D F James, P Hillmen
No abstract text is available yet for this article.
February 3, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28130182/induction-of-cftr-gene-expression-by-1-25-oh-2-vitamin-d3-25oh-vitamin-d3-and-vitamin-d3-in-cultured-human-airway-epithelial-cells-and-in-mouse-airways
#20
Kristina M DiFranco, Jennifer K Mulligan, Aman S Sumal, Gill Diamond
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which often leads to protein misfolding and no CFTR surface localization. This then leads to chronic airway infections, inflammation, and tissue damage. Although vitamin D has been explored as a therapy to treat CF due to its antimicrobial-inducing and anti-inflammatory properties, the effect of 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3) on CFTR directly has not been studied...
January 24, 2017: Journal of Steroid Biochemistry and Molecular Biology
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