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https://www.readbyqxmd.com/read/28934350/correction-magnetic-cell-labeling-of-primary-and-stem-cell-derived-pig-hepatocytes-for-mri-based-cell-tracking-of-hepatocyte-transplantation
#1
Dwayne R Roach, Wesley M Garrett, Glenn Welch, Dorela D Shuboni-Mulligan, Thomas J Caperna, Neil C Talbot, Erik M Shapiro
[This corrects the article DOI: 10.1371/journal.pone.0123282.].
2017: PloS One
https://www.readbyqxmd.com/read/28924479/marked-hyperandrogenicity-in-a-60-year-old-woman
#2
Khaled Aljenaee, Sulaiman Ali, Seong Keat Cheah, Owen MacEneaney, Niall Mulligan, Neil Hickey, Tommy Kyaw Tun, Seamus Sreenan, John H McDermott
Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21 nmol/L (normal range: 0...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28916627/interactions-between-medial-prefrontal-cortex-and-dorsomedial-striatum-are-necessary-for-odor-span-capacity-in-rats-role-of-glun2b-containing-nmda-receptors
#3
Don A Davies, Quentin Greba, Jantz C Selk, Jillian K Catton, Landon D Baillie, Sean J Mulligan, John G Howland
Working memory is involved in the maintenance and manipulation of information essential for complex cognition. While the neural substrates underlying working memory capacity have been studied in humans, considerably less is known about the circuitry mediating working memory capacity in rodents. Therefore, the present experiments tested the involvement of medial prefrontal cortex (mPFC) and dorsal striatum (STR) in the odor span task (OST), a task proposed to assay working memory capacity in rodents. Initially, Long Evans rats were trained to dig in scented sand for food following a serial delayed nonmatching-to-sample rule...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28913852/testing-support-for-the-northern-and-southern-dispersal-routes-out-of-africa-an-analysis-of-levantine-and-southern-arabian-populations
#4
Deven N Vyas, Ali Al-Meeri, Connie J Mulligan
OBJECTIVES: The Northern Dispersal Route (NDR) and Southern Dispersal Route (SDR) are hypothesized to have been used by modern humans in the dispersal out of Africa. The NDR follows the Nile into Northeast Africa and crosses the Red Sea into the Levant. The SDR emerges from the Horn of Africa and crosses the Bab el-Mandeb into southern Arabia. In this study, we analyze genetic data from populations living along the NDR and SDR to test support for each dispersal route. MATERIALS AND METHODS: We genotyped 90 Yemeni samples on the Affymetrix Human Origins array...
September 15, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28903799/a-comparison-of-outcomes-according-to-different-diagnostic-systems-for-delirium-dsm-5-dsm-iv-cam-and-drs-r98
#5
Dimitrios Adamis, David Meagher, Siobhan Rooney, Owen Mulligan, Geraldine McCarthy
Studies indicate that DSM-5 criteria for delirium are relatively restrictive, and identify different cases of delirium compared with previous systems. We evaluate four outcomes of delirium (mortality, length of hospital stay, institutionalization, and cognitive improvement) in relation to delirium defined by different DSM classification systems. Prospective, longitudinal study of patients aged 70+ admitted to medical wards of a general hospital. Participants were assessed up to a maximum of four times during two weeks, using DSM-5 and DSM-IV criteria, DRS-R98 and CAM scales as proxies for DSM III-R and DSM III...
September 14, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28899948/happy-20th-anniversary-men1-from-positional-cloning-to-gene-function-restoration
#6
EDITORIAL
Frank Weber, Lois M Mulligan
No abstract text is available yet for this article.
October 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28899898/investigating-the-association-of-rs2910164-with-cancer-in-irish-patients
#7
Terri Patricia McVeigh, Robert J Mulligan, Una Mary McVeigh, Patrick W Owens, Nicola Miller, Marcia Bell, Frederic Sebag, Carole Guerin, Denis Quill, Joanne Barnes Weidhaas, Michael Kerin, Aoife J Lowery
INTRODUCTION: Micro(mi)-RNAs are small non-coding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger-(m)RNA. MiR146a has a role in inflammation, and may have a role as a tumour suppressor. The polymorphism rs2910164 in pre-mir146a has been implicated in inflammatory pathologies, including cancers of the breast and thyroid; although evidence for association is conflicting in different populations. We aimed to investigate the association of this variant with these two cancers in an Irish cohort...
September 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28882468/inclusive-design-in-architectural-practice-experiential-learning-of-disability-in-architectural-education
#8
Kerry Mulligan, Allyson Calder, Hilda Mulligan
BACKGROUND: The built environment can facilitate or impede an individual's ability to participate in society. This is particularly so for people with disability. Architects are well placed to be advocates for design that enhances societal equality. OBJECTIVE: This qualitative study explored architectural design students' perceptions of inclusive design, their reflections resulting from an experiential learning module and the subsequent influence of these on their design practice...
August 31, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28873128/safety-and-feasibility-of-antiretroviral-preexposure-prophylaxis-for-adolescent-men-who-have-sex-with-men-aged-15-to-17-years-in-the-united-states
#9
Sybil G Hosek, Raphael J Landovitz, Bill Kapogiannis, George K Siberry, Bret Rudy, Brandy Rutledge, Nancy Liu, D Robert Harris, Kathleen Mulligan, Gregory Zimet, Kenneth H Mayer, Peter Anderson, Jennifer J Kiser, Michelle Lally, Jennifer Brothers, Kelly Bojan, Jim Rooney, Craig M Wilson
Importance: Adolescents represent a key population for implementing preexposure prophylaxis (PrEP) interventions worldwide, yet tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for PrEP is only licensed for adults. Objective: To examine the safety of and adherence to PrEP along with changes in sexual risk behavior among adolescent men who have sex with men (MSM). Design, Setting, and Participants: Adolescent Medicine Trials Network for HIV/AIDS Interventions 113 (Project PrEPare) was a PrEP demonstration project that evaluated the safety, tolerability, and acceptability of TDF/FTC and patterns of use, rates of adherence, and patterns of sexual risk behavior among healthy young MSM aged 15 to 17 years...
September 5, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28862883/randomized-phase-ii-study-of-r-chop-with-or-without-bortezomib-in-previously-untreated-patients-with-non-germinal-center-b-cell-like-diffuse-large-b-cell-lymphoma
#10
John P Leonard, Kathryn S Kolibaba, James A Reeves, Anil Tulpule, Ian W Flinn, Tatjana Kolevska, Robert Robles, Christopher R Flowers, Robert Collins, Nicholas J DiBella, Steven W Papish, Parameswaran Venugopal, Andrew Horodner, Amir Tabatabai, Julio Hajdenberg, Jaehong Park, Rachel Neuwirth, George Mulligan, Kaveri Suryanarayan, Dixie-Lee Esseltine, Sven de Vos
Purpose To evaluate the impact of the addition of bortezomib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) on outcomes in previously untreated patients with non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL). Patients and Methods After real-time determination of non-GCB DLBCL using the Hans immunohistochemistry algorithm, 206 patients were randomly assigned (1:1; stratified by International Prognostic Index [IPI] score) to six 21-day cycles of standard R-CHOP alone or R-CHOP plus bortezomib 1...
September 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28829680/american-telemedicine-association-operating-procedures-for-pediatric-telehealth
#11
S David McSwain, Jordana Bernard, Bryan L Burke, Stacey L Cole, Madan Dharmar, Julie Hall-Barrow, Neil Herendeen, Pamela Herendeen, Elizabeth A Krupinski, Amanda Martin, Dan McCafferty, Deborah Ann Mulligan, Steve North, Jennifer Ruschman, Morgan Waller, Kathleen Webster, Sherrie Williams, Susan Yamamoto, Brooke Yeager
No abstract text is available yet for this article.
September 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28828144/assessment-of-radiometer-calibration-with-gps-radio-occultation-for-the-mirata-cubesat-mission
#12
Anne D Marinan, Kerri L Cahoy, Rebecca L Bishop, Susan S Lui, James R Bardeen, Tamitha Mulligan, William J Blackwell, R Vincent Leslie, Idahosa Osaretin, Michael Shields
The Microwave Radiometer Technology Acceleration (MiRaTA) is a 3U CubeSat mission sponsored by the NASA Earth Science Technology Office (ESTO). The science payload on MiRaTA consists of a tri-band microwave radiometer and Global Positioning System (GPS) radio occultation (GPSRO) sensor. The microwave radiometer takes measurements of all-weather temperature (V-band, 50-57 GHz), water vapor (G-band, 175-191 GHz), and cloud ice (G-band, 205 GHz) to provide observations used to improve weather forecasting. The Aerospace Corporation's GPSRO experiment, called the Compact TEC (Total Electron Content) and Atmospheric GPS Sensor (CTAGS), measures profiles of temperature and pressure in the upper troposphere/lower stratosphere (∼20 km) and electron density in the ionosphere (over 100 km)...
December 2016: IEEE J Sel Top Appl Earth Obs Remote Sens
https://www.readbyqxmd.com/read/28818404/report-of-the-ishlt-working-group-on-primary-lung-graft-dysfunction-part-iii-mechanisms-a-2016-consensus-group-statement-of-the-international-society-for-heart-and-lung-transplantation
#13
EDITORIAL
Andrew E Gelman, Andrew J Fisher, Howard J Huang, Maher A Baz, Ciara M Shaver, Thomas M Egan, Micheal S Mulligan
No abstract text is available yet for this article.
July 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28817419/the-association-of-fat-and-lean-tissue-with-whole-body-and-spine-bone-mineral-density-is-modified-by-hiv-status-and-sex-in-children-and-youth
#14
Denise L Jacobson, Jane C Lindsey, Brent A Coull, Kathleen Mulligan, Priya Bhagwat, Grace M Aldrovandi
BACKGROUND: HIV-infected (HIV-pos) male children/youth showed lower bone mineral density at sexual maturity than HIV-uninfected (HIV-neg) females. It is not known whether complications of HIV disease, including abnormal body fat distribution, contribute to lower bone accrual in male HIV-pos adolescents. METHODS: In a cross-sectional study, we evaluated the relationship between body composition (fat and lean mass) and bone mass in HIV-pos and HIV-neg children/youth and determined if it is modified by HIV status and sex...
August 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28801978/mindfulness-of-voices-self-compassion-and-secure-attachment-in-relation-to-the-experience-of-hearing-voices
#15
James Dudley, Catrin Eames, John Mulligan, Naomi Fisher
OBJECTIVES: Developing compassion towards oneself has been linked to improvement in many areas of psychological well-being, including psychosis. Furthermore, developing a non-judgemental, accepting way of relating to voices is associated with lower levels of distress for people who hear voices. These factors have also been associated with secure attachment. This study explores associations between the constructs of mindfulness of voices, self-compassion, and distress from hearing voices and how secure attachment style related to each of these variables...
August 12, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28794017/differential-recruitment-of-e3-ubiquitin-ligase-complexes-regulates-ret-isoform-internalization
#16
Brandy D Hyndman, Mathieu J F Crupi, Susan Peng, Leslie N Bone, Aisha N Rekab, Eric Y Lian, Simona M Wagner, Costin N Antonescu, Lois M Mulligan
The RET receptor tyrosine kinase is implicated in normal development and cancer. RET is expressed as two isoforms, RET9 and RET51, with unique C-terminal tail sequences that recruit distinct protein complexes to mediate signals. Upon activation, RET isoforms are internalized with distinct kinetics, suggesting differences in regulation. Here, we demonstrate that RET9 and RET51 differ in their abilities to recruit E3-ubiquitin ligases to their unique C-termini. RET51, but not RET9, interacts with, and is ubiquitinated by CBL, which is recruited through interactions with the GRB2 adaptor protein...
August 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28783501/high-risk-family-colorectal-cancer-screening-service-in-ireland-critical-review-of-clinical-outcomes
#17
Margaret Walshe, Robert Moran, Marie Boyle, Ion Cretu, Zita Galvin, Victoria Swan, Jason Trikovic, Michael P Farrell, Sinéad Foy, Loretta O'Brien, Jan Leyden, Niall Mulligan, Helen Fenlon, David J Gallagher, Padraic MacMathúna
BACKGROUND: We present the 15-year experience of a family colorectal cancer screening service in Ireland with emphasis on real life experience and outcomes. METHODS: Questionnaires were used to assess family cancer history and assign patients to risk categories; 'Moderate Risk', HNPCC, (suspected) genetic syndrome (non-HNPCC), 'Low Risk'. Screening was by full colonoscopy. We report neoplastic yield, examining effect of risk category, age, gender, and index colonoscopy findings...
August 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28779840/pinning-down-the-mechanism-of-transport-probing-the-structure-and-function-of-transporters-using-cysteine-cross-linking-and-site-specific-labeling
#18
Christopher Mulligan, Joseph A Mindell
Transporters are crucial in a number of cellular functions, including nutrient uptake, cell signaling, and toxin removal. As such, transporters are important drug targets and their malfunction is related to several disease states. Treating transporter-related diseases and developing pharmaceuticals targeting transporters require an understanding of their mechanism. Achieving a detailed understanding of transporter mechanism depends on an integrative approach involving structural and computational approaches as well as biochemical and biophysical methodologies...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28771053/recommendations-for-skin-cancer-monitoring-for-patients-with-chronic-lymphocytic-leukemia
#19
Anthea Mulcahy, Stephen P Mulligan, Stephen P Shumack
No abstract text is available yet for this article.
August 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28763731/natural-assurance-scheme-a-level-playing-field-framework-for-green-grey-infrastructure-development
#20
Benjamin Denjean, Mónica A Altamirano, Nina Graveline, Raffaele Giordano, Peter van der Keur, David Moncoulon, Josh Weinberg, María Máñez Costa, Zdravko Kozinc, Mark Mulligan, Polona Pengal, John Matthews, Nora van Cauwenbergh, Elena López Gunn, David N Bresch
This paper proposes a conceptual framework to systematize the use of Nature-based solutions (NBS) by integrating their resilience potential into Natural Assurance Scheme (NAS), focusing on insurance value as corner stone for both awareness-raising and valuation. As such one of its core goal is to align research and pilot projects with infrastructure development constraints and priorities. Under NAS, the integrated contribution of natural infrastructure to Disaster Risk Reduction is valued in the context of an identified growing need for climate robust infrastructure...
July 29, 2017: Environmental Research
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