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Sam Porter, Tracey McConnell, Mike Clarke, Jenny Kirkwood, Naomi Hughes, Lisa Graham-Wisener, Joan Regan, Miriam McKeown, Kerry McGrillen, Joanne Reid
BACKGROUND: Music therapy is increasingly used as an adjunct therapy to support symptom management in palliative care. However, studies to date have paid little attention to the processes that lead to changes in patient outcomes. To fill this gap, we examined the processes and experiences involved in the introduction of music therapy as an adjunct complementary therapy to palliative care in a hospice setting in the United Kingdom (UK). METHODS: Using a realistic evaluation approach, we conducted a qualitative study using a variety of approaches...
December 8, 2017: BMC Palliative Care
Sigrun Badrnya, Tara Doherty, Ciaran Richardson, Robert I McConnell, John V Lamont, Michael Veitinger, Stephen P FitzGerald, Maria Zellner, Ellen Umlauf
BACKGROUND: Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validated assay for rapid and reliable APOE4 classification is therefore advantageous. METHODS: Biochip array technology (BAT) was successfully applied to identify directly the APOE4 status from plasma within 3 h, through simultaneous immunoassay-based detection of both specific APOE4 and total APOE levels...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
Hui Zhou, Xia Iona Li, Jeong Hee Kim, Muhammad T Salam, Hyo Bin Kim, Rob S McConnell, Rima Habre, Tracy Bastain, Shohreh F Farzan, Jill Johnston, Frank D Gilliland
No abstract text is available yet for this article.
December 5, 2017: Annals of Allergy, Asthma & Immunology
Suman Mallick, Ye Lu, Ming Hui Luo, Miao Meng, Ying Ning Tan, Chun Y Liu, Jing-Lin Zuo
We have synthesized and characterized the mixed-ligand dimolybdenum paddlewheel complex Na[(DAniF)3Mo2(C3S5)] (Na[1]; DAniF = N,N'-di-p-anisylformamidinate, dmit = 1,3-dithiole-2-thione-4,5-dithiolate), which has a six-membered chelating [Mo2S2C2] ring created by equatorial coordination of the dmit (C3S5) ligand to the Mo2 unit. One-electron oxidation of Na[1] using Cp2FePF6 yields the neutral complex [(DAniF)3Mo2(C3S5)] ([1]), and removal of two electrons from Na[1] using AgBPh4 gives [(DAniF)3Mo2(C3S5)]BPh4 ([1]BPh4)...
December 5, 2017: Inorganic Chemistry
Nathan D Wiebracht, Shan He, Colin Cotton, Jareen Meinzen-Derr, Gordon Shott, David F Smith, Keith B McConnell, Stacey L Ishman
Objective Home oximetry is commonly used to screen for obstructive sleep apnea (OSA) in children; however, normal oxygen desaturation levels by disease severity are not well known. It was our objective to determine if oxygen saturation levels differed by OSA severity category in children and if these differences were similar for preteen children and adolescents. Study Design Retrospective case series of children undergoing polysomnography from September 2011 to July 2015. Setting Tertiary pediatric hospital...
November 1, 2017: Otolaryngology—Head and Neck Surgery
Simonne Cohen, Ben D Fulcher, Shantha M W Rajaratnam, Russell Conduit, Jason P Sullivan, Melissa A St Hilaire, Andrew J K Phillips, Tobias Loddenkemper, Sanjeev V Kothare, Kelly McConnell, Paula Braga-Kenyon, William Ahearn, Andrew Shlesinger, Jacqueline Potter, Frank Bird, Kim M Cornish, Steven W Lockley
Increased severity of problematic daytime behavior has been associated with poorer sleep quality in individuals with autism spectrum disorder. In this work, we investigate whether this relationship holds in a real-time setting, such that an individual's prior sleep can be used to predict their subsequent daytime behavior. We analyzed an extensive real-world dataset containing over 20,000 nightly sleep observations matched to subsequent challenging daytime behaviors (aggression, self-injury, tantrums, property destruction and a challenging behavior index) across 67 individuals with low-functioning autism living in two U...
December 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
Lise J Harbom, Nadine Michel, Michael J McConnell
Neural stem and progenitor cells produce one of the most remarkable organs in nature, the human brain. Among neural stem cell progeny, post-mitotic neurons are likewise remarkably diverse. Single-cell transcriptomic approaches are now cataloging a long-sought-after molecular taxonomy of neuronal diversity in the brain. Contemporary single-cell omic classifications of neuronal diversity build from electrophysiological approaches that for decades have measured and cataloged diverse biophysical properties of single neurons...
November 29, 2017: Cell and Tissue Research
Katrina Ortblad, Daniel Kibuuka Musoke, Thomson Ngabirano, Aidah Nakitende, Jonathan Magoola, Prossy Kayiira, Geoffrey Taasi, Leah G Barresi, Jessica E Haberer, Margaret A McConnell, Catherine E Oldenburg, Till Bärnighausen
BACKGROUND: HIV self-testing allows HIV testing at any place and time and without health workers. HIV self-testing may thus be particularly useful for female sex workers (FSWs), who should test frequently but face stigma and financial and time barriers when accessing healthcare facilities. METHODS AND FINDINGS: We conducted a cluster-randomized controlled health systems trial among FSWs in Kampala, Uganda, to measure the effect of 2 HIV self-testing delivery models on HIV testing and linkage to care outcomes...
November 2017: PLoS Medicine
Raviprasad Kattimani, Jamie McConnell, Jon Waite
Introduction: We present a case of 12 year old boy presented with right hip pain, fever and antalgic gait. Inflammatory markers were raised at presentation. The pelvic radiograph and ultra sound scan of right hip joint did not detect any abnormality. The Magnetic Resonance Imaging (MRI) scans revealed inflammatory oedema in the right gluteus medius muscle. He was treated with intravenous Flucloxacillin for 10 days and later 6 weeks of oral Flucloxacillin. At the 6 weeks follow up patient was asymptomatic with normal gait...
July 2017: Journal of Orthopaedic Case Reports
Rebecca Kohnken, Jing Wen, Bethany Mundy-Bosse, Kathleen McConnell, Ashleigh Keiter, Leah Grinshpun, Alex Hartlage, Max Yano, Betina McNeil, Nitin Chakravarti, Basem William, James E Bradner, Michael A Caligiuri, Pierluigi Porcu, Anjali Mishra
MicroRNA dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), a uniformly fatal malignancy of skin-homing CD4+ T-cells for which there are few effective therapies. The role of microRNAs (miRs) in controlling epigenetic modifier-dependent transcriptional regulation in CTCL is unknown. In this study, we characterize a novel miR dysregulation contributing to overexpression of epigenetic reader bromodomain-containing protein 4 (BRD4). Using patient CD4+ T-cells, we show diminished levels of miR-29b compared to healthy donor cells...
November 27, 2017: Blood
Donald Warne, Kristen Dulacki, Margaret Spurlock, Thomas Meath, Melinda M Davis, Bill Wright, K John McConnell
OBJECTIVES: To assess the prevalence of Adverse Childhood Experiences (ACEs) and their association with behavioral health in American Indian (AI) and non-AI populations in South Dakota. METHODS: We included the validated ACE questionnaire in a statewide health survey of 16,001 households. We examined the prevalence of ACEs and behavioral health conditions in AI and non-AI populations and associations between ACEs and behavioral health. RESULTS: Compared with non-AIs, AIs displayed higher prevalence of ACEs including abuse, neglect, and household dysfunction and had a higher total number of ACEs...
2017: Journal of Health Care for the Poor and Underserved
Benjamin C Sun, Nicoleta Lupulescu-Mann, Christina J Charlesworth, Hyunjee Kim, Daniel M Hartung, Richard A Deyo, K John McConnell
STUDY OBJECTIVE: The link between prescription opioid shopping and overdose events is poorly understood. We test the hypothesis that a history of prescription opioid shopping is associated with increased risk of overdose events. METHODS: This is a secondary analysis of a linked claims and controlled substance dispense database. We studied adult Medicaid beneficiaries in 2014 with prescription opioid use in the 6 months before an ambulatory care or emergency department visit with a pain-related diagnosis...
November 23, 2017: Annals of Emergency Medicine
Cathleen S Colón-Emeric, Kirsten N Corazzini, Eleanor S McConnell, Wei Pan, Mark P Toles, Rasheeda Hall, Melissa Batchelor-Murphy, Tracey L Yap, Amber L Anderson, Andrew Burd, Sathya Amarasekara, Ruth A Anderson
OBJECTIVES: Validated process measures that correlate with patient outcomes are needed for research and quality improvement. DESIGN: Cross-sectional analysis within a cluster-randomized fall prevention study. SETTING: Nursing homes in North Carolina (n = 16). PARTICIPANTS: Nursing home staff (n = 541) and residents with 1 or more falls in 6 months (n = 597). MEASUREMENTS: Fall-prevention process measures in 4 categories derived from Assessing Care of Vulnerable Elders quality indicators were measured in 2 ways: (1) chart abstraction; and (2) staff responses to clinical vignettes of hypothetical residents at risk for falls...
November 21, 2017: Journal of the American Medical Directors Association
Kristin H Dwyer, Joshua S Rempell, Michael B Stone
OBJECTIVE: The study objective was to investigate the combined accuracy of right heart strain on focused cardiac ultrasound (FOCUS) and deep vein thrombosis (DVT) on compression ultrasound (CUS) for identification of centrally located pulmonary embolism (PE) diagnosed on computed tomography pulmonary angiography (CTPA). METHODS: This was a prospective observational study using a convenience sample of patients undergoing CTPA in the emergency department (ED) for evaluation of PE...
November 14, 2017: American Journal of Emergency Medicine
Matthew McConnell, Josh Baisden, Andra E Duncan
No abstract text is available yet for this article.
August 12, 2017: Journal of Cardiothoracic and Vascular Anesthesia
John McConnell
No abstract text is available yet for this article.
December 2017: Lancet Infectious Diseases
William R McConnell
Research on relationships and health often interprets culture as the passively transmitted "content" of social ties, an approach that overlooks the influence of cultural resources on relationships themselves. I propose that mental health patients seek social support partly based on cultural resources held by their network members, including members' medical knowledge and beliefs. I test hypotheses using data from the Indianapolis Network Mental Health Study, an egocentric network survey of new mental health patients ( N = 152) and their personal relationships ( N = 1,868)...
December 2017: Journal of Health and Social Behavior
Emilie Mchantaf, Hicham Mansour, Joseph Sabbagh, Mireille Feghali, Robbie J McConnell
Improving patients’ aesthetics is an important request in daily practice. Tooth whitening is a treatment option available for improving aesthetics. This paper will pose questions asked by our patients on bleaching techniques and outcomes and offer appropriate up-to-date answers. Clinical relevance: This paper addresses the most important questions raised by patients and colleagues concerning vital tooth whitening (VTW).
January 2017: Dental Update
Hannah McConnell, Rachel White, Jane Maher
OBJECTIVES: The aim of this study is to categorise cancers into broad groups based on clusters of common treatment aims, experiences and outcomes to provide a numerical framework for understanding the services required to meet the needs of people with different cancers. This framework will enable a high-level overview of care and support requirements for the whole cancer population. SETTING AND PARTICIPANTS: People in the UK with 1 of 20 common cancers; an estimated 309 000 diagnoses in 2014, 1 679 000 people diagnosed in a 20-year period and still living in 2010 and 135 000 cancer deaths in 2014...
November 22, 2017: BMJ Open
Ailian Xiong, Jessica Haithcock, Yingying Liu, Lauren Eusner, Matthew McConnell, Howard D White, Betty Belknap, Eva Forgacs
Mutations in the MYO7A gene, encoding the motor protein myosin VIIa, can cause Usher 1B, a deafness/blindness syndrome in humans, and the shaker-1 phenotype, characterized by deafness, head tossing and circling behavior, in mice. Myosin VIIa is responsible for tension bearing and the transduction mechanism in the stereocilia and for melanosome transport in the retina, in line with the phenotypic outcomes observed in mice. However, the effect of the shaker-1 mutation, a R502P amino acid substitution, on the motor function is unclear...
November 22, 2017: Journal of Biological Chemistry
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