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https://www.readbyqxmd.com/read/28735295/azithromycin-for-episodes-with-asthma-like-symptoms-in-young-children-aged-1-3-years
#1
Katy McConnell, Michael Shields
N/A.
July 22, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28730729/traffic-related-air-pollution-associations-with-cytokeratin-18-a-marker-of-hepatocellular-apoptosis-in-an-overweight-and-obese-paediatric-population
#2
S Hsieh, B P Leaderer, A E Feldstein, N Santoro, L A McKay, S Caprio, R McConnell
INTRODUCTION: Traffic-related air pollution causes fatty liver, inflammation and fibrosis in animal models, but there have been few studies in humans. OBJECTIVES: To test the hypothesis that traffic-related air pollution causes non-alcoholic fatty liver disease (NAFLD) and increased markers for non-alcoholic steatohepatitis (NASH); and that NAFLD increases liver susceptibility to increased NASH risk. METHODS: Data collected prospectively from 74 overweight or obese children were obtained from the Yale Pediatric Obesity Clinic...
July 20, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28729354/continuous-flow-lvad-support-causes-a-distinct-form-of-intestinal-angiodysplasia
#3
Jooeun Kang, Samson Hennessy-Strahs, Pawel Kwiatkowski, Christian Bermudez, Michael A Acker, Pavan Atluri, Patrick McConnell, Carlo R Bartoli
Rationale: The objective of this autopsy study was to determine whether abnormal gastrointestinal vascularity develops during continuous-flow LVAD support. Objective: Left ventricular assist device (LVAD) support causes pathologic degradation of von Willebrand factor (vWF) and bleeding from gastrointestinal angiodysplasia at an alarming rate. It has been speculated that LVAD support, itself may cause angiodysplasia. The relationship to abnormal vWF metabolism is unknown. We tested the hypothesis that abnormal gastrointestinal vascularity develops during continuous-flow LVAD support...
July 20, 2017: Circulation Research
https://www.readbyqxmd.com/read/28722316/the-mincle-ligand-trehalose-dibehenate-differentially-modulates-m1-like-and-m2-like-macrophage-phenotype-and-function-via-syk-signaling
#4
Kristel Kodar, Jacquie L Harper, Melanie J McConnell, Mattie S M Timmer, Bridget L Stocker
INTRODUCTION: Macrophages play a significant role in the progression of diseases, such as cancer, making them a target for immune-modulating agents. Trehalose dibehenate (TDB) is known to activate M1-like macrophages via Mincle, however, the effect of TDB on M2-like macrophages, which are found in the tumor microenvironment, has not been studied. METHODS: qRT-PCR, flow cytometry, cytokine ELISA, and Western Blotting were used to study the effect of TDB on GM-CSF and M-CSF/IL-4 derived bone marrow macrophages (BMMs) from C57BL/6 and Mincle(-/-) mice...
July 19, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28720627/costs-of-transforming-established-primary-care-practices-to-patient-centered-medical-homes-pcmhs
#5
Neil S Fleming, Briget da Graca, Gerald O Ogola, Steven D Culler, Jessica Austin, Patrice McConnell, Russell McCorkle, Phil Aponte, Michael Massey, Cliff Fullerton
BACKGROUND: The patient-centered medical home (PCMH) shows promise for improving care and reducing costs. We sought to reduce the uncertainty regarding the time and cost of PCMH transformation by quantifying the direct costs of transforming 57 practices in a medical group to National Committee for Quality Assurance (NCQA)-recognized Level III PCMHs. METHODS: We conducted structured interviews with corporate leaders, and with physicians, practice administrators, and office managers from a representative sample of practices regarding time spent on PCMH transformation and NCQA application, and related purchases...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28705377/load-adaptability-in-patients-with-pulmonary-arterial-hypertension
#6
Myriam Amsallem, David Boulate, Marie Aymami, Julien Guihaire, Mona Selej, Jennie Huo, Andre Y Denault, Michael V McConnell, Ingela Schnittger, Elie Fadel, Olaf Mercier, Roham T Zamanian, Francois Haddad
Right ventricular (RV) adaptation to pressure overload is a major prognostic factor in patients with pulmonary arterial hypertension (PAH). The objectives were first to define the relation between RV adaptation and load using allometric modeling, then to compare the prognostic value of different indices of load adaptability in PAH. Both a derivation (n = 85) and a validation cohort (n = 200) were included. Load adaptability was assessed using 3 approaches: (1) surrogates of ventriculo-arterial coupling (e...
June 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28694338/no-effect-of-commercial-cognitive-training-on-neural-activity-during-decision-making
#7
Joseph W Kable, M Kathleen Caulfield, Mary Falcone, Mairead McConnell, Leah Bernardo, Trishala Parthasarathi, Nicole Cooper, Rebecca Ashare, Janet Audrain-McGovern, Robert Hornik, Paul Diefenbach, Frank J Lee, Caryn Lerman
Increased preference for immediate over delayed and for risky over certain rewards has been associated with unhealthy behavioral choices. Motivated by evidence that enhanced cognitive control can shift choice behavior away from immediate and risky rewards, we tested whether training executive cognitive function could influence choice behavior and brain responses. In this randomized controlled trial, 128 young adults (71 male, 57 female) participated in 10 weeks of training with either a commercial web-based cognitive training program or web-based video games that do not specifically target executive function or adapt the level of difficulty throughout training...
July 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28687283/advanced-and-extended-scope-practice-of-diagnostic-radiographers-in-scotland-exploring-strategic-imaging-service-imperatives
#8
I Henderson, S A Mathers, J McConnell
INTRODUCTION: The development of diagnostic imaging services manifests features specific to the Scottish environment, in particular development of the radiographic workforce through implementing skills mix and role developments to enhance outcomes for patients. A component of a College of Radiographers Industry Partnership Scheme (CoRIPS) supported study, this research investigates perspectives of strategic service managers with Health Board responsibility for service delivery. METHOD: A questionnaire survey was administered to strategic service managers across Scotland (N = 14), followed up with telephone interviews...
August 2017: Radiography
https://www.readbyqxmd.com/read/28671484/express-recommendations-for-the-clinical-management-of-patients-receiving-macitentan-for-pulmonary-arterial-hypertension-pah-a-delphi-consensus-document
#9
Franck F Rahaghi, Hassan Alnuaimat, Rana L A Awdish, Vijay P Balasubramanian, Robert C Bourge, Charles D Burger, John A Butler, C Gregory Cauthen, Murali Chakinala, Bennett P deBoisblanc, Michael S Eggert, Peter Engel, Jeremy Feldman, J Wesley McConnell, Myung H Park, Jeffrey S Sager, Namita Sood, Harold I Palevsky
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28670841/the-sensitivity-of-38-heart-rate-variability-measures-to-the-addition-of-artifact-in-human-and-artificial-24-hr-cardiac-recordings
#10
Nicolas J C Stapelberg, David L Neumann, David H K Shum, Harry McConnell, Ian Hamilton-Craig
BACKGROUND: Artifact is common in cardiac RR interval data derived from 24-hr recordings and has a significant impact on heart rate variability (HRV) measures. However, the relative impact of progressively added artifact on a large group of commonly used HRV measures has not been assessed. This study compared the relative sensitivity of 38 commonly used HRV measures to artifact to determine which measures show the most change with increasing increments of artifact. A secondary aim was to ascertain whether short-term and long-term HRV measures, as groups, share similarities in their sensitivity to artifact...
July 2, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28666909/the-healing-influence-of-nature
#11
Kathryn McConnell Greven
No abstract text is available yet for this article.
April 13, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28657712/a-ruthenium-ii-complex-as-a-luminescent-probe-for-dna-mismatches-and-abasic-sites
#12
Adam N Boynton, Lionel Marcélis, Anna J McConnell, Jacqueline K Barton
[Ru(bpy)2(BNIQ)](2+) (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28648681/traumatic-brain-injury-severity-comorbidity-social-support-family-functioning-and-community-reintegration-among-veterans-of-the-afghanistan-and-iraq-wars
#13
Mary Jo Pugh, Alicia A Swan, Kathleen F Carlson, Carlos A Jaramillo, Blessen C Eapen, Christina Dillahunt-Aspillaga, Megan E Amuan, Roxana Delgado, Kimberly McConnell, Erin P Finley, Jordan Grafman
OBJECTIVE: Examine the association between traumatic brain injury (TBI) severity and social, family, community reintegration outcomes as well as return to work status among Post-9/11 veterans in Department of Veterans Affairs (VA) care. DESIGN: Retrospective observational cohort study. SETTING: Mail/online survey fielded to a national sample of veterans. PARTICIPANTS: Among a sample of Post-9/11 veterans with at least 3 years of VA care stratified according to TBI severity and comorbidities, 2023 completed and returned surveys...
June 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28646041/concurrent-ox40-and-cd30-ligand-blockade-abrogates-the-cd4-driven-autoimmunity-associated-with-ctla4-and-pd1-blockade-while-preserving-excellent-anti-cd8-tumor-immunity
#14
Maher G Nawaf, Maria H Ulvmar, David R Withers, Fiona M McConnell, Fabrina M Gaspal, Gwilym J Webb, Nick D Jones, Hideo Yagita, James P Allison, Peter J L Lane
Although strategies that block FOXP3-dependent regulatory T cell function (CTLA4 blockade) and the inhibitory receptor PD1 have shown great promise in promoting antitumor immune responses in humans, their widespread implementation for cancer immunotherapy has been hampered by significant off-target autoimmune side effects that can be lethal. Our work has shown that absence of OX40 and CD30 costimulatory signals prevents CD4 T cell-driven autoimmunity in Foxp3-deficient mice, suggesting a novel way to block these side effects...
June 23, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28636838/searching-for-affective-and-cognitive-restoration-examining-the-restorative-effects-of-casual-video-game-play
#15
Michael A Rupp, Richard Sweetman, Alejandra E Sosa, Janan A Smither, Daniel S McConnell
OBJECTIVE: We investigated the effects of a passive break, relaxation activity, and casual video game on affect, stress, engagement, and cognitive performance. BACKGROUND: Reducing stress and improving cognitive performance is critical across many domains. Previous studies investigated taking a break, relaxation techniques, or playing a game; however, these methods have not been compared within a single experiment. METHOD: Participants completed a baseline affective and cognitive assessment (ACA), which included the Positive and Negative Affect Schedule, shortened version of the Dundee Stress State Questionnaire, and backward digit-span...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28626335/2-dimensional-analysis-of-low-limb-taping-methods-on-ambulation-for-stroke-patients
#16
Jung-Ho Lee
[Purpose] The purpose of this study was to investigate the effect of treatment on the type of taping applied before proprioceptive neuromuscular facilitation treatment. [Subjects and Methods] This study was conducted on thirty patients diagnosed with stroke. The study subjects were divided into three groups: experimental group 1, experimental group 2, and control group 3. Experimental group 1 applied Kinesio taping to the lower limb before applying proprioceptive neuromuscular facilitation technique. Experimental group 2 applied McConnell taping to the lower limb before applying proprioceptive neuromuscular facilitation technique and control group applied only proprioceptive neuromuscular facilitation technique...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28622786/dairy-cow-disability-weights
#17
Craig S McConnel, Ashleigh A McNeil, Joleen C Hadrich, Jason E Lombard, Franklyn B Garry, Jane Heller
Over the past 175 years, data related to human disease and death have progressed to a summary measure of population health, the Disability-Adjusted Life Year (DALY). As dairies have intensified there has been no equivalent measure of the impact of disease on the productive life and well-being of animals. The development of a disease-adjusted metric requires a consistent set of disability weights that reflect the relative severity of important diseases. The objective of this study was to use an international survey of dairy authorities to derive disability weights for primary disease categories recorded on dairies...
August 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28622389/-foraging-for-a-place-to-lay-eggs-a-genetic-link-between-foraging-behaviour-and-oviposition-preferences
#18
Murray W McConnell, Mark J Fitzpatrick
Gravid female arthropods in search of egg-laying substrates embark on foraging-like forays: they survey the environment assessing multiple patches, tasting each with their tarsi and proboscis, and then, if interested, they deposit an egg (or eggs). In fruit flies, Drosophila melanogaster, allelic variation in the foraging gene (for) underlies the rover/sitter foraging behaviour polymorphism. Rover flies (forR) are more active foragers (both within and between food patches) compared to sitters (fors). In nematodes, Caenorhabditis elegans, a mutation in egl-4, the ortholog of for, leads to aberrations in egg laying...
2017: PloS One
https://www.readbyqxmd.com/read/28622095/black-and-white-lies-race-based-biases-in-deception-judgments
#19
E Paige Lloyd, Kurt Hugenberg, Allen R McConnell, Jonathan W Kunstman, Jason C Deska
In six studies ( N = 605), participants made deception judgments about videos of Black and White targets who told truths and lies about interpersonal relationships. In Studies 1a, 1b, 1c, and 2, White participants judged that Black targets were telling the truth more often than they judged that White targets were telling the truth. This truth bias was predicted by Whites' motivation to respond without prejudice. For Black participants, however, motives to respond without prejudice did not moderate responses (Study 2)...
June 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28617653/systematic-review-of-the-effect-of-taping-techniques-on-patellofemoral-pain-syndrome
#20
Catherine A Logan, Abhiram R Bhashyam, Ashley J Tisosky, Daniel B Haber, Anna Jorgensen, Adam Roy, Matthew T Provencher
CONTEXT: Taping is commonly used in the management of several musculoskeletal conditions, including patellofemoral pain syndrome (PFPS). Specific guidelines for taping are unknown. OBJECTIVE: To investigate the efficacy of knee taping in the management of PFPS. Our hypothesis was that tension taping and exercise would be superior to placebo taping and exercise as well as to exercise or taping alone. DATA SOURCES: The PubMed/MEDLINE, Cochrane, Rehabilitation and Sports Medicine Source, and CINAHL databases were reviewed for English-language randomized controlled trials (RCTs) evaluating the efficacy of various taping techniques that were published between 1995 and April 2015...
June 1, 2017: Sports Health
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