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https://www.readbyqxmd.com/read/29433336/dumbell-atypical-teratoid-rhabdoid-tumour-at-rt-of-the-cervical-spine
#1
Amit Amit, Atul Vats, Alireza Shoakazemi, Brian Herron, Anthony McCarthy, Robert Scott McConnell
Spinal Atypical Teratoid/Rhabdoid Tumour (AT/RT) is a highly malignant tumour, and its prognosis is dismal especially for very young patients. In this article, we present the case of a teenage boy with AT/RT in the cervical spine and its multimodality management. A review of the literature on ATRT of the spine is also presented.
February 12, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29404757/motivated-reasoning-and-hiv-risk-views-on-relationships-trust-and-risk-from-young-women-in-cape-town-south-africa-and-implications-for-oral-prep
#2
Miriam Hartmann, Margaret McConnell, Linda-Gail Bekker, Connie Celum, Thola Bennie, Jabulisile Zuma, Ariane van der Straten
In high prevalence environments relationship characteristics are likely to be associated with HIV risk, yet evidence indicates general underestimation of risk. Furthermore uncertainty about partner's risk may challenge PrEP demand among young African women. We conducted quantitative and qualitative interviews with women before and after HIV discussions with partners, to explore how partner's behavior affected risk perceptions and interest in PrEP. Twenty-three women were interviewed once; twelve had a follow-up interview after speaking to their partners...
February 5, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29400695/claudin-18-mediated-yap-activity-regulates-lung-stem-and-progenitor-cell-homeostasis-and-tumorigenesis
#3
Beiyun Zhou, Per Flodby, Jiao Luo, Dan R Castillo, Yixin Liu, Fa-Xing Yu, Alicia McConnell, Bino Varghese, Guanglei Li, Nyam-Osor Chimge, Mitsuhiro Sunohara, Michael N Koss, Wafaa Elatre, Peter Conti, Janice M Liebler, Chenchen Yang, Crystal N Marconett, Ite A Laird-Offringa, Parviz Minoo, Kunliang Guan, Barry R Stripp, Edward D Crandall, Zea Borok
Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we demonstrated that knockout of Cldn18, a claudin family member highly expressed in lung alveolar epithelium, leads to lung enlargement, parenchymal expansion, increased abundance and proliferation of known distal lung progenitors, the alveolar epithelial type II (AT2) cells, activation of Yes-associated protein (YAP), increased organ size, and tumorigenesis in mice...
February 5, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29396742/a-review-of-diagnostic-accuracy-and-clinical-impact-from-the-focused-use-of-perioperative-ultrasound
#4
REVIEW
Daniel Bainbridge, Brie McConnell, Colin Royse
PURPOSE: To perform a narrative review of the current trials examining the use of perioperative ultrasound to diagnose common issues related to the heart, lungs, stomach, and airway. METHOD: A review of the current literature was conducted in June 2017 on all trials involving ultrasound, including both surface and transesophageal ultrasound, in the perioperative period. The search included the terms 'ultrasonography', 'perioperative care', 'point-of-care', and 'bedside'...
February 2, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29386252/tumour-risks-and-genotype-phenotype-correlations-associated-with-germline-variants-in-succinate-dehydrogenase-subunit-genes-sdhb-sdhc-and-sdhd
#5
Katrina A Andrews, David B Ascher, Douglas Eduardo Valente Pires, Daniel R Barnes, Lindsey Vialard, Ruth T Casey, Nicola Bradshaw, Julian Adlard, Simon Aylwin, Paul Brennan, Carole Brewer, Trevor Cole, Jackie A Cook, Rosemarie Davidson, Alan Donaldson, Alan Fryer, Lynn Greenhalgh, Shirley V Hodgson, Richard Irving, Fiona Lalloo, Michelle McConachie, Vivienne P M McConnell, Patrick J Morrison, Victoria Murday, Soo-Mi Park, Helen L Simpson, Katie Snape, Susan Stewart, Susan E Tomkins, Yvonne Wallis, Louise Izatt, David Goudie, Robert S Lindsay, Colin G Perry, Emma R Woodward, Antonis C Antoniou, Eamonn R Maher
BACKGROUND: Germline pathogenic variants in SDHB/SDHC/SDHD are the most frequent causes of inherited phaeochromocytomas/paragangliomas. Insufficient information regarding penetrance and phenotypic variability hinders optimum management of mutation carriers. We estimate penetrance for symptomatic tumours and elucidate genotype-phenotype correlations in a large cohort of SDHB/SDHC/SDHD mutation carriers. METHODS: A retrospective survey of 1832 individuals referred for genetic testing due to a personal or family history of phaeochromocytoma/paraganglioma...
January 31, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29383978/of-two-minds-or-one-a-registered-replication-of-rydell-et%C3%A2-al-2006
#6
Tobias Heycke, Sarah Gehrmann, Julia M Haaf, Christoph Stahl
Evaluative conditioning (EC) is proposed as a mechanism of automatic preference acquisition in dual-process theories of attitudes (Gawronski, B., & Bodenhausen, G. V. (2006). Associative and propositional processes in evaluation: An integrative review of implicit and explicit attitude change. Psychological Bulletin, 132(5), 692-731. doi:10.1037/0033-2909.132.5.692). Evidence for the automaticity of EC comes from studies claiming EC effects for subliminally presented stimuli. An impression-formation study showed a selective influence of briefly presented primes on implicitly measured attitudes, whereas supraliminally presented behavioural information about the target person was reflected in explicit ratings (Rydell, R...
January 31, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29382705/discovery-of-potent-and-selective-mrck-inhibitors-with-therapeutic-effect-on-skin-cancer
#7
Mathieu Unbekandt, Simone Belshaw, Justin Bower, Maeve Clarke, Jacqueline Cordes, Diane Crighton, Daniel R Croft, Martin J Drysdale, Mathew J Garnett, Kathryn Gill, Christopher Gray, David A Greenhalgh, James Am Hall, Jennifer Konczal, Sergio Lilla, Duncan McArthur, Patricia McConnell, Laura McDonald, Lynn McGarry, Heather McKinnon, Carol McMenemy, Mokdad Mezna, Nicholas A Morrice, June Munro, Gregory Naylor, Nicola Rath, Alexander W Schüttelkopf, Mairi Sime, Michael F Olson
The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The absence of highly potent and selective MRCK inhibitors has resulted in relatively little knowledge of the potential roles of these kinases in cancer. Here we report the discovery of the azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors that reduce substrate phosphorylation, leading to morphological changes in cancer cells along with inhibition of their motility and invasive character...
January 30, 2018: Cancer Research
https://www.readbyqxmd.com/read/29376441/spontaneous-haemorrhage-into-a-large-abducens-nerve-schwannoma-a-case-report
#8
Daniel Brown, Nicolas McConnell, Richard List, Farouk Olubajo, Robin Highley, Mathew Storey, Gueorgui Kounin
PURPOSE: Abducens schwannomas are rare tumors that are not known to present with acute haemorrhage. We present a case of a 59 year-old female on warfarin who presented acutely with a sudden onset headache, nausea and photophobia. Neuroimaging revealed an acute haemorrhage into a lesion that entered Dorello's canal and was consistent with an abducens nerve schwannoma. MATERIALS AND METHODS: The patient's case notes, imaging, histology and operative recording were reviewed retrospectively to compile this case report...
January 29, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29370999/a-comparison-of-three-apolipoprotein-b-methods-and-their-associations-with-incident-coronary-heart-disease-risk-over-a-12-year-follow-up-period-the-multi-ethnic-study-of-atherosclerosis
#9
Jing Cao, Brian T Steffen, Weihua Guan, Alan T Remaley, Joseph P McConnell, Vikram Palamalai, Michael Y Tsai
BACKGROUND: Apolipoprotein B-100 (ApoB) is a well-researched lipoprotein marker used in assessing the risk of coronary heart disease (CHD) development. Despite its continued use at the bedside, ApoB methodologies have not been thoroughly compared and may differentially discriminate CHD risk, resulting in patient misclassification. OBJECTIVE: This study compared 3 ApoB immunoassays and their associations with incident CHD risk over a 12-year follow-up period in the Multi-Ethnic Study of Atherosclerosis...
December 29, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29370121/polymorphisms-mutations-in-a-kinase-anchoring-proteins-akaps-role-in-the-cardiovascular-system
#10
REVIEW
Santosh V Suryavanshi, Shweta M Jadhav, Bradley K McConnell
A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases. By scaffolding these proteins together, AKAPs build a "signalosome" at specific subcellular locations and compartmentalize PKA signaling. Thus, AKAPs are important for signal transduction after upstream activation of receptors ensuring accuracy and precision of intracellular PKA-dependent signaling pathways...
January 25, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29358271/catalogue-of-inherited-disorders-found-among-the-irish-traveller-population
#11
Sally Ann Lynch, Ellen Crushell, Deborah M Lambert, Niall Byrne, Kathleen Gorman, Mary D King, Andrew Green, Siobhan O'Sullivan, Fiona Browne, Joanne Hughes, Ina Knerr, Ahmad A Monavari, Melanie Cotter, Vivienne P M McConnell, Bronwyn Kerr, Simon A Jones, Catriona Keenan, Nuala Murphy, Declan Cody, Sean Ennis, Jackie Turner, Alan D Irvine, Jillian Casey
Background Irish Travellers are an endogamous, nomadic, ethnic minority population mostly resident on the island of Ireland with smaller populations in Europe and the USA. High levels of consanguinity result in many rare autosomal recessive disorders. Due to founder effects and endogamy, most recessive disorders are caused by specific homozygous mutations unique to this population. Key clinicians and scientists with experience in managing rare disorders seen in this population have developed a de facto advisory service on differential diagnoses to consider when faced with specific clinical scenarios...
January 22, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29356752/from-the-editor
#12
Charles R McConnell
No abstract text is available yet for this article.
January 2018: Health Care Manager
https://www.readbyqxmd.com/read/29348013/dose-dependent-cardioprotection-of-moderate-32%C3%A2-c-versus-mild-35%C3%A2-c-therapeutic-hypothermia-in-porcine-acute%C3%A2-myocardial-infarction
#13
Rajesh Dash, Yoshiaki Mitsutake, Wook Bum Pyun, Fady Dawoud, Jennifer Lyons, Atsushi Tachibana, Kazuyuki Yahagi, Yuka Matsuura, Frank D Kolodgie, Renu Virmani, Michael V McConnell, Uday Illindala, Fumiaki Ikeno, Alan Yeung
OBJECTIVES: The study investigated whether a dose response exists between myocardial salvage and the depth of therapeutic hypothermia. BACKGROUND: Cardiac protection from mild hypothermia during acute myocardial infarction (AMI) has yielded equivocal clinical trial results. Rapid, deeper hypothermia may improve myocardial salvage. METHODS: Swine (n = 24) undergoing AMI were assigned to 3 reperfusion groups: normothermia (38°C) and mild (35°C) and moderate (32°C) hypothermia...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29346053/what-is-your-diagnosis
#14
Beatrice E Carletti, Fraser J McConnell, Daniel Sanchez-Masian
No abstract text is available yet for this article.
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29337773/prognostic-factors-for-locoregional-recurrence-in-neuroendocrine-tumors-of-the-rectum
#15
Erica S Tsang, Yarrow J McConnell, David F Schaeffer, Yaling Yin, Caroline H Speers, Hagen F Kennecke
BACKGROUND: Optimal management of rectal neuroendocrine tumors is not yet well defined. Various pathologic factors, particularly tumor size, have been proposed as prognostic markers. OBJECTIVE: We characterized sequential patients diagnosed with rectal neuroendocrine tumors in a population-based setting to determine whether tumor size and other pathologic markers could be useful in guiding locoregional management. DESIGN: This study is a retrospective analysis of data from the British Columbia provincial cancer registry...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29333889/risking-it-anyway-an-adolescent-case-study-of-trauma-sexual-and-gender-identities-and-relationality
#16
Elizabeth A McConnell
This article presents the case of a Chinese-American adolescent with a significant trauma history who was questioning her sexual and gender identities. The implications of the client's intersecting identities for case conceptualization and treatment are considered within the framework of affirmative practices for sexual and gender minority (SGM) clients. The impacts of stress and trauma on this client's experiences-and SGM clients more broadly-are also considered, particularly with respect to how this client understood and negotiated her experiences of relational trauma...
January 15, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29333886/anaemia-worsens-early-functional-outcome-after-traumatic-brain-injury-a-preliminary-study
#17
N Scott Litofsky, Douglas C Miller, Zhenzhou Chen, Agnes Simonyi, Diana Klakotskaia, Andrew Giritharan, Qi Feng, Diane McConnell, Jiankun Cui, Zezong Gu
OBJECTIVE: To determine early effects on outcome from traumatic brain injury (TBI) induced by controlled cortical impact (CCI) associated with anaemia in mice. HYPOTHESIS: Outcome from TBI with concomitant anaemia would be worse than TBI without anaemia. METHODS: CCI was induced with electromagnetic impaction in four groups of C57BL/6J mice: sham, sham+anaemia; TBI; and TBI+anaemia. Anaemia was created by withdrawal of 30% of calculated intravascular blood volume and saline replacement of equal volume...
January 15, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29327189/using-a-high-organic-matter-biowall-to-treat-a-trichloroethylene-plume-at-the-beaver-dam-road-landfill
#18
Gabriela T Niño de Guzmán, Cathleen J Hapeman, Patricia D Millner, Laura L McConnell, Dana Jackson, David Kindig, Alba Torrents
Trichloroethylene (TCE) is a highly effective industrial degreasing agent and known carcinogen. It was frequently buried improperly in landfills and has subsequently become one of the most common groundwater and soil contaminants in the USA. A common strategy to remediate TCE-contaminated sites and to prevent movement of the TCE plumes into waterways is to construct biowalls which consist of biomaterials and amendments to enhance biodegradation. This approach was chosen to contain a TCE plume emanating from a closed landfill in Maryland...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29323933/cardioventilatory-control-in-preterm-born-children-and-the-risk-of-obstructive-sleep-apnea
#19
Keren Armoni Domany, Md Monir Hossain, Leonardo Nava-Guerra, Michael C Khoo, Keith McConnell, John L Carroll, Yuanfang Xu, Mark DiFrancesco, Raouf S Amin
Rationale The contribution of ventilatory control to the pathogenesis of obstructive sleep apnea (OSA) in preterm born children is unknown. Objectives To characterize phenotypes of ventilatory control that are associated with the presence of OSA in preterm born children during early childhood. Methods Preterm and term born children without comorbid conditions were enrolled. They were categorized into OSA group and non-OSA group based on polysomnography. Measurements Loop gain, controller gain and plant gain, reflecting ventilatory instability, chemoreceptor sensitivity and blood gas response to a change in ventilation, respectively, were estimated from spontaneous sighs identified during polysomnography...
January 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29322639/prokaryotes-in-the-wais-divide-ice-core-reflect-source-and-transport-changes-between-last-glacial-maximum-and-the-early-holocene
#20
Pamela A Santibáñez, Olivia J Maselli, Mark C Greenwood, Mackenzie M Grieman, Eric S Saltzman, Joseph R McConnell, John C Priscu
We present the first long-term, highly resolved prokaryotic cell concentration record obtained from a polar ice core. This record, obtained from the West Antarctic Ice Sheet (WAIS) Divide (WD) ice core, spanned from the Last Glacial Maximum (LGM) to the early Holocene (EH) and showed distinct fluctuations in prokaryotic cell concentration coincident with major climatic states. The time series also revealed a ~1,500-year periodicity with greater amplitude during the Last Deglaciation (LDG). Higher prokaryotic cell concentration and lower variability occurred during the LGM and EH than during the LDG...
January 11, 2018: Global Change Biology
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