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https://www.readbyqxmd.com/read/29650415/pulmonary-vein-stenosis-in-infants-a-systematic-review-meta-analysis-and-meta-regression
#1
Carl H Backes, Erin Nealon, Aimee K Armstrong, Clifford L Cua, Courtney Mitchell, Usha Krishnan, Rachel D Vanderlaan, Mi Kyoung Song, Nicola Viola, Charles V Smith, Patrick I McConnell, Brian K Rivera, Jeffrey Bridge
OBJECTIVE: To quantify outcomes of infants (<1 year of age) diagnosed with pulmonary vein stenosis (PVS). STUDY DESIGN: MEDLINE (PubMed), Scopus, and Web of Science were searched through February 1, 2017, with no language restrictions. Publications including infants diagnosed with primary PVS, defined as the absence of preceding intervention(s), were considered. The study was performed according to Meta-analysis of Observational Studies in Epidemiology guidelines, the Systematic Reviews, and Meta-Analysis checklist, and registered prospectively...
April 9, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29619738/uphill-energy-transfer-in-photosystem-i-from-chlamydomonas-reinhardtii-time-resolved-fluorescence-measurements-at-77-k
#2
Wojciech Giera, Sebastian Szewczyk, Michael D McConnell, Kevin E Redding, Rienk van Grondelle, Krzysztof Gibasiewicz
Energetic properties of chlorophylls in photosynthetic complexes are strongly modulated by their interaction with the protein matrix and by inter-pigment coupling. This spectral tuning is especially striking in photosystem I (PSI) complexes that contain low-energy chlorophylls emitting above 700 nm. Such low-energy chlorophylls have been observed in cyanobacterial PSI, algal and plant PSI-LHCI complexes, and individual light-harvesting complex I (LHCI) proteins. However, there has been no direct evidence of their presence in algal PSI core complexes lacking LHCI...
April 4, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29618598/routine-assessment-and-promotion-of-physical-activity-in-healthcare-settings-a-scientific-statement-from-the-american-heart-association
#3
REVIEW
Felipe Lobelo, Deborah Rohm Young, Robert Sallis, Michael D Garber, Sandra A Billinger, John Duperly, Adrian Hutber, Russell R Pate, Randal J Thomas, Michael E Widlansky, Michael V McConnell, Elizabeth A Joy
Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. Improving and maintaining recommended levels of physical activity leads to reductions in metabolic, hemodynamic, functional, body composition, and epigenetic risk factors for noncommunicable chronic diseases. Physical activity also has a significant role, in many cases comparable or superior to drug interventions, in the prevention and management of >40 conditions such as diabetes mellitus, cancer, cardiovascular disease, obesity, depression, Alzheimer disease, and arthritis...
April 4, 2018: Circulation
https://www.readbyqxmd.com/read/29608365/primary-care-practices-abilities-and-challenges-in-using-electronic-health-record-data-for-quality-improvement
#4
Deborah J Cohen, David A Dorr, Kyle Knierim, C Annette DuBard, Jennifer R Hemler, Jennifer D Hall, Miguel Marino, Leif I Solberg, K John McConnell, Len M Nichols, Donald E Nease, Samuel T Edwards, Winfred Y Wu, Hang Pham-Singer, Abel N Kho, Robert L Phillips, Luke V Rasmussen, F Daniel Duffy, Bijal A Balasubramanian
Federal value-based payment programs require primary care practices to conduct quality improvement activities, informed by the electronic reports on clinical quality measures that their electronic health records (EHRs) generate. To determine whether EHRs produce reports adequate to the task, we examined survey responses from 1,492 practices across twelve states, supplemented with qualitative data. Meaningful-use participation, which requires the use of a federally certified EHR, was associated with the ability to generate reports-but the reports did not necessarily support quality improvement initiatives...
April 2018: Health Affairs
https://www.readbyqxmd.com/read/29605114/digital-training-platform-for-interpreting-radiographic-images-of-the-chest
#5
L McLaughlin, N Woznitza, A Cairns, S L McFadden, R Bond, C M Hughes, A Elsayed, D Finlay, J McConnell
INTRODUCTION: Time delays and errors exist which lead to delays in patient care and misdiagnosis. Reporting clinicians follow guidance to form their own search strategy. However, little research has tested these training guides. With the use of eye tracking technology and expert input we developed a digital training platform to be used in chest image interpretation learning. METHODS: Two sections of a digital training platform were planned and developed; A) a search strategy training tool to assist reporters during their interpretation of images, and B) an educational tool to communicate the search strategies of expert viewers to trainees by using eye tracking technology...
May 2018: Radiography
https://www.readbyqxmd.com/read/29600899/human-muscle-specific-a-kinase-anchoring-protein-makap-polymorphisms-modulate-the-susceptibility-to-cardiovascular-diseases-by-altering-camp-pka-signaling
#6
Santosh V Suryavanshi, Shweta M Jadhav, Kody L Anderson, Panagiotis Katsonis, Olivier Lichtarge, Bradley K McConnell
One of the crucial cardiac signaling pathways is cAMP-mediated PKA signal transduction which is regulated by a family of scaffolding proteins, A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) partly regulates cardiac cAMP/PKA signaling by binding to PKA and phosphodiesterase4D3 (PDE4D3) among other proteins and plays a central role in modulating cardiac remodeling. Moreover, genetics plays an incomparable role in modifying the risk of cardiovascular diseases (CVDs). Especially, single nucleotide polymorphisms (SNPs) in various proteins have been shown to predispose individuals to CVDs...
March 30, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29595530/cor-pulmonale-in-children-with-acute-respiratory-failure-on-venovenous-extracorporeal-membrane-oxygenation
#7
Patrick I McConnell, Don Hayes
No abstract text is available yet for this article.
March 26, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29594338/macro-and-micromechanical-remodelling-in-the-fish-atrium-is-associated-with-regulation-of-collagen-1-alpha-3-chain-expression
#8
Adam N Keen, Andrew J Fenna, James C McConnell, Michael J Sherratt, Peter Gardner, Holly A Shiels
Numerous pathologies lead to remodelling of the mammalian ventricle, often associated with fibrosis. Recent work in fish has shown that fibrotic remodelling of the ventricle is 'reversible', changing seasonally as temperature-induced changes in blood viscosity alter haemodynamic load on the heart. The atrial response to varying haemodynamic load is less understood in mammals and completely unexplored in non-mammalian vertebrates. To investigate atrial remodelling, rainbow trout were chronically cooled (from 10 ± 1 to 5 ± 1 °C) and chronically warmed (from 10 ± 1 to 18 ± 1 °C) for a minimum of 8 weeks...
March 28, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29588905/endoscopic-endonasal-resection-of-a-suprasellar-pituitary-adenoma-mimicking-tuberculum-sellae-meningioma-in-a-patient-with-an-intrasellar-persistent-trigeminal-artery
#9
Alaa S Montaser, Alexandre B Todeschini, Juan M Revuelta Barbero, Mostafa Shahein, E Antonio Chiocca, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
A 50-year-old female with an incidentally diagnosed suprasellar lesion was initially managed conservatively due to the presence of an intrasellar persistent trigeminal artery going through the dorsum sellae and fundamentally forming the blood supply of the entire posterior circulation. Serial follow-up brain magnetic resonance imaging (MRI) revealed progressive enlargement of the suprasellar lesion over 4 years period. Surgery was indicated after the initial tumor growth; however, the patient refused surgery for fear of complications related to the persistent trigeminal artery...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29577303/ct-findings-in-pneumocystis-carinii-pneumonia-in-five-dogs
#10
F Schiborra, C J Scudder, R M Littler, C R Lamb, J F McConnell, T W Maddox
Pneumocystis carinii pneumonia is a rare disease in dogs. It is primarily reported in cavalier King Charles spaniels and miniature dachshunds with suspected underlying immunodeficiency. This case series reports the findings in five dogs (four cavalier King Charles spaniels and one Bedlington terrier) with confirmed P. carinii pneumonia. Thoracic (CT) revealed ground glass opacity of the pulmonary parenchyma with a diffuse or multifocal distribution. The severity of this pattern was variable. Less consistent imaging findings included parenchymal bands, bronchial dilation and signs consistent with pulmonary hypertension...
March 25, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29570774/application-of-the-mesolens-for-subcellular-resolution-imaging-of-intact-larval-and-whole-adult-drosophila
#11
G McConnell, W B Amos
In a previous paper, we showed a new giant lens called the Mesolens and presented performance data and images from whole fixed and intact fluorescently-stained 12.5-day old mouse embryos. Here, we show that using the Mesolens we can image an entire Drosophila larva or adult fly in confocal epifluorescence and show subcellular detail in all tissues. By taking several hundreds of optical sections through the entire volume of the specimen, we show cells and nuclear details within the gut, brain, salivary glands and reproductive system that normally require dissection for study...
March 23, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29561551/a-novel-method-for-source-specific-hemoglobin-adducts-of-nitro-polycyclic-aromatic-hydrocarbons
#12
Kylie Wheelock, Junfeng Jim Zhang, Rob McConnell, Deliang Tang, Heather E Volk, Ya Wang, Julie B Herbstman, Shuang Wang, David H Phillips, David Camann, Jicheng Gong, Frederica Perera
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposure are needed for targeting interventions to protect children. Nitro-derivatives of PAH can act as markers of exposure to diesel exhaust, gasoline exhaust, or general combustion sources. Using a novel HPLC-APCI-MS/MS detection method, we examined four hemoglobin (Hb) adducts of nitro-PAH metabolites and the Hb adduct of a benzo[a]pyrene (BaP) metabolite in 22 umbilical cord blood samples...
March 21, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29553629/precommitment-cash-transfers-and-timely-arrival-for-birth-evidence-from-a-randomized-controlled-trial-in-nairobi-kenya
#13
Jessica Cohen, Katherine Lofgren, Margaret McConnell
No abstract text is available yet for this article.
May 2017: American Economic Review
https://www.readbyqxmd.com/read/29553459/air-toxics-in-relation-to-autism-diagnosis-phenotype-and-severity-in-a-u-s-family-based-study
#14
Amy E Kalkbrenner, Gayle C Windham, Cheng Zheng, Rob McConnell, Nora L Lee, James J Schauer, Brian Thayer, Juhi Pandey, Heather E Volk
BACKGROUND: Previous studies have reported associations of perinatal exposure to air toxics, including some metals and volatile organic compounds, with autism spectrum disorder (ASD). OBJECTIVES: Our goal was to further explore associations of perinatal air toxics with ASD and associated quantitative traits in high-risk multiplex families. METHODS: We included participants of a U.S. family-based study [the Autism Genetic Resource Exchange (AGRE)] who were born between 1994 and 2007 and had address information...
March 12, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29546228/multiple-minority-stress-and-lgbt-community-resilience-among-sexual-minority-men
#15
Elizabeth A McConnell, Patrick Janulis, Gregory Phillips, Roky Truong, Michelle Birkett
Minority stress theory has widespread research support in explaining health disparities experienced by sexual and gender minorities. However, less is known about how minority stress impacts multiply marginalized groups, such as lesbian, gay, bisexual, and transgender people of color (LGBT POC). Also, although research has documented resilience in the face of minority stress at the individual level, research is needed that examines macro-level processes such as community resilience (Meyer, 2015). In the current study, we integrate minority stress theory and intersectionality theory to examine multiple minority stress (i...
March 2018: Psychology of Sexual Orientation and Gender Diversity
https://www.readbyqxmd.com/read/29540556/agreement-between-transverse-t2-weighted-and-three-dimensional-constructive-interference-in-steady-state-sequences-in-the-evaluation-of-spinal-cord-disease-in-dogs
#16
Maria Oliveira, James Fraser McConnell, Thomas W Maddox, Daniel Sanchez-Masian, Rita Gonçalves
The constructive interference in steady state (CISS) sequence has been widely used in human neuroimaging. It has been shown to be advantageous in the evaluation of intra-axial and extra-axial cystic abnormalities, arteriovenous and dysraphic malformations and disturbances of cerebrospinal fluid circulation. To assess the utility of this technique in small animals, interpretations based on this sequence were compared with those based on T2-weighted (T2W) sequences in 145 dogs that underwent MRI of the spine for suspected spinal cord disease...
March 14, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29538109/a-call-to-investigate-the-relationship-between-education-and-health-outcomes-using-big-data
#17
Saad Chahine, Kulamakan Mahan Kulasegaram, Sarah Wright, Sandra Monteiro, Lawrence E M Grierson, Cassandra Barber, Stefanie S Sebok-Syer, Meghan McConnell, Wendy Yen, Andre De Champlain, Claire Touchie
There exists an assumption that improving medical education will improve patient care. While seemingly logical, this premise has rarely been investigated. In this Invited Commentary, the authors propose the use of big data to test this assumption. The authors present a few example research studies linking education and patient care outcomes and argue that using big data may more easily facilitate the process needed to investigate this assumption. The authors also propose that collaboration is needed to link educational and health care data...
March 13, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29529478/assessment-of-particulate-matter-and-ammonia-emission-concentrations-and-respective-plume-profiles-from-a-commercial-poultry-house
#18
Qi Yao, Zijiang Yang, Hong Li, Michael D Buser, John D Wanjura, Peter M Downey, Chen Zhang, Collin Craige, Alba Torrents, Laura L McConnell, Gregory A Holt, Cathleen J Hapeman
Poultry-emitted air pollutants, including particulate matter (PM) and ammonia, have raised concerns due to potential negative effects on human health and the environment. However, developing and optimizing remediation technologies requires a better understanding of air pollutant concentrations, the emission plumes, and the relationships between the pollutants. Therefore, we conducted ten field experiments to characterize PM (total suspended particulate [TSP], particulate matter less than 10 μm in aerodynamic diameter [PM10 ], and particulate matter less than 2...
March 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29507899/exploring-opportunities-to-prevent-cirrhosis-admissions-in-the-emergency-department-a-multicenter-multidisciplinary-survey
#19
Shazia Mehmood Siddique, Meghan Lane-Fall, Matthew J McConnell, Neha Jakhete, James Crismale, Stefanie Porges, Vandana Khungar, Shivan J Mehta, David Goldberg, Zhiping Li, Thomas Schiano, Linda Regan, Clinton Orloski, Judy A Shea
Patients with cirrhosis have high admission and readmission rates, and it is estimated that a quarter are potentially preventable. Little data are available regarding nonmedical factors impacting triage decisions in this patient population. This study sought to explore such factors as well as to determine provider perspectives on low-acuity clinical presentations to the emergency department, including ascites and hepatic encephalopathy. A survey was distributed in four liver transplant centers to both emergency medicine and hepatology providers, who included attending physicians, house staff, and advanced practitioners; 196 surveys were returned (estimated response rate 50...
March 2018: Hepatology communications
https://www.readbyqxmd.com/read/29507715/a-comparison-of-a-novel-time-based-summary-measure-of-dairy-cow-health-against-cumulative-disease-frequency
#20
Craig S McConnel, Ashleigh A McNeil, Joleen C Hadrich, Jason E Lombard, Jane Heller, Franklyn B Garry
Background: There is an increasing push for dairy production to be scientifically grounded and ethically responsible in the oversight of animal health and well-being. Addressing underlying challenges affecting the quality and length of productive life necessitates novel assessment and accountability metrics. Human medical epidemiologists developed the Disability-Adjusted Life Year metric as a summary measure of health addressing the complementary nature of disease and death. The goal of this project was to develop and implement a dairy Disease-Adjusted Lactation (DALact) summary measure of health, as a comparison against cumulative disease frequency...
2018: Irish Veterinary Journal
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