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Michael McConnell, Rajendra Kumar, Behrang Amini, Patrick P Lin, Wei-Lien Wang
We present the case of an 83-year-old man who had painful swelling of right knee for 6 months. Radiographs showed a large intra-articular soft-tissue mass with small calcifications, whereas MRI detected a multilobulated intra-articular tumor with bone erosions at the distal femur. Histopathology of ultrasound-guided biopsy specimen of the synovial mass revealed it to be a poorly differentiated metastatic carcinoma. Abdominal computed tomography with intravenous contrast medium administration found a heterogeneously enhancing large right renal mass with calcifications, which was shown to be a renal cell carcinoma on histopathology...
October 20, 2016: Skeletal Radiology
Bonnie B McConnell
Drawing on ethnographic research with kanyeleng fertility society performers and health workers in The Gambia (2012-2013), this paper uses a social capital approach to analyze the relationship between musical performance and health communication. Health communication research has demonstrated the important role of social capital in mediating the impact of interventions. Music research has drawn attention to performance as a site in which social relationships and obligations are produced and negotiated. In this paper, I bring these two perspectives together in order to open up new ways of thinking about musical performance as a culturally appropriate strategy in health communication...
September 19, 2016: Social Science & Medicine
Emma Elison, Louise K Vigsnaes, Laura Rindom Krogsgaard, Julie Rasmussen, Nikolaj Sørensen, Bruce McConnell, Thierry Hennet, Morten O A Sommer, Peter Bytzer
The gut microbiota has been established as an important player influencing many aspects of human physiology. Breast milk, the first diet for an infant, contains human milk oligosaccharides (HMO) that shape the infant's gut microbiota by selectively stimulating the growth of specific bacteria, especially bifidobacteria. In addition to their bifidogenic activity, the ability of HMO to modulate immune function and the gut barrier makes them prime candidates to restore a beneficial microbiota in dysbiotic adults and provide health benefits...
October 2016: British Journal of Nutrition
Elizabeth A McConnell, Michelle Birkett, Brian Mustanski
PURPOSE: Lesbian, gay, bisexual, and transgender (LGBT) adolescents are at greater risk for mental health problems than their heterosexual peers, in part due to victimization. Social support, particularly from families, has been identified as an important promotive factor. However, little is known about how LGBT youth experience multiple forms of support or how early support predicts mental health across adolescence and into young adulthood. METHODS: In an analytic sample of 232 LGBT youth aged 16-20 years at baseline across 5...
October 1, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Evan P McConnell, Robin M Queen
BACKGROUND: Functional recovery following total ankle arthroplasty (TAA) is assessed with patient-reported metrics, but physical performance tests may allow for a more accurate assessment of patient function. We quantified correlations between patient-reported measures and physical performance tests in patients after TAA to determine the usefulness of physical performance tests in post-TAA assessment. METHODS: In total, 140 patients with end-stage ankle osteoarthritis were assessed prior to TAA and again at 12 and 24 months postoperatively...
October 2, 2016: Foot & Ankle International
Cynthia Gobbi Alves Araújo, Christiane de Souza Guerino Macedo, Daiene Ferreira, Leonardo Shigaki, Rubens A da Silva
: The purpose of this study was to assess the effect of patellar taping on muscle activation of the knee and hip muscles in women with Patellofemoral Pain Syndrome during five proprioceptive exercises. Forty sedentary women with syndrome were randomly allocated in two groups: Patellar Taping (based in McConnell) and Placebo (vertical taping on patella without any stretching of lateral structures of the knee). Volunteers performed five proprioceptive exercises randomly: Swing apparatus, Mini-trampoline, Bosu balance ball, Anteroposterior sway on a rectangular board and Mediolateral sway on a rectangular board...
September 21, 2016: Journal of Electromyography and Kinesiology
Toshiro Kitagawa, Hisanori Kosuge, Masaki Uchida, Yasunori Iida, Ronald L Dalman, Trevor Douglas, Michael V McConnell
PURPOSE: To evaluate Arg-Gly-Asp (RGD)-conjugated human ferritin (HFn) iron oxide nanoparticles for in vivo magnetic resonance imaging (MRI) of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm (AAA). MATERIALS AND METHODS: HFn was genetically engineered to express the RGD peptide and Fe3 O4 nanoparticles were chemically synthesized inside the engineered HFn (RGD-HFn). Macrophage-rich left carotid lesions were induced by ligation in FVB mice made hyperlipidemic and diabetic (n = 14), with the contralateral right carotid serving as control...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Colin D Bruzewicz, Robert McConnell, John Chiaverini, Jeremy M Sage
Two-dimensional arrays of trapped-ion qubits are attractive platforms for scalable quantum information processing. Sufficiently rapid reloading capable of sustaining a large array, however, remains a significant challenge. Here with the use of a continuous flux of pre-cooled neutral atoms from a remotely located source, we achieve fast loading of a single ion per site while maintaining long trap lifetimes and without disturbing the coherence of an ion quantum bit in an adjacent site. This demonstration satisfies all major criteria necessary for loading and reloading extensive two-dimensional arrays, as will be required for large-scale quantum information processing...
2016: Nature Communications
Jonathan S Harrison, Shellaine R Frazier, Dianne D McConnell, Senan John Yasar, Nataliya Melnyk, Gratian Salaru
Acquired coagulopathies are common; uncommonly, adsorption of coagulation factors from the circulation into the tissues by pathologic amyloid exceeds the body's ability to produce factor and results in acquired factor deficiency. When amyloidosis does cause a coagulopathy, it is most often acquired factor X deficiency, but there are rare reports of amyloidosis being associated with other acquired factor deficiencies. We investigated a case of a severe bleeding diathesis, the cause of which was combined acquired factor V deficiency and concomitant acquired von Willebrand syndrome...
September 24, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
P Mathen, Y McConnell, R Yeung, D Graham, H K Warkentin, B Warkentin, K Joseph, C M Doll
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Rebecca McConnell, Jasmine Y Zheng, Edmund H Chadd, Claire Kalpakjian
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Emily G Werth, Evan W McConnell, T S Karim Gilbert, Inmaculada Couso Lianez, Carlos A Perez, Cherrel K Manley, Lee M Graves, James G Umen, Leslie M Hicks
Identifying dynamic protein phosphorylation events is critical for understanding kinase/phosphatase regulated signaling pathways. To date, protein phosphorylation and kinase expression have been examined independently in photosynthetic organisms. Presented here is a method to study the global kinome and phosphoproteome in tandem in the model photosynthetic organism, the alga Chlamydomonas reinhardtii (Chlamydomonas), using mass spectrometry-based label-free proteomics. A dual enrichment strategy targets intact protein kinases via capture on immobilized multiplexed inhibitor beads (MIBs) with subsequent proteolytic digestion of unbound proteins and peptide-based phosphorylation enrichment...
September 27, 2016: Plant Journal: for Cell and Molecular Biology
Karen Low, Tazeen Ashraf, Natalie Canham, Jill Clayton-Smith, Charu Deshpande, Alan Donaldson, Richard Fisher, Frances Flinter, Nicola Foulds, Alan Fryer, Kate Gibson, Ian Hayes, Alison Hills, Susan Holder, Melita Irving, Shelagh Joss, Emma Kivuva, Kathryn Lachlan, Alex Magee, Vivienne McConnell, Meriel McEntagart, Kay Metcalfe, Tara Montgomery, Ruth Newbury-Ecob, Fiona Stewart, Peter Turnpenny, Julie Vogt, David Fitzpatrick, Maggie Williams, Sarah Smithson
KBG syndrome is characterized by short stature, distinctive facial features, and developmental/cognitive delay and is caused by mutations in ANKRD11, one of the ankyrin repeat-containing cofactors. We describe 32 KBG patients aged 2-47 years from 27 families ascertained via two pathways: targeted ANKRD11 sequencing (TS) in a group who had a clinical diagnosis of KBG and whole exome sequencing (ES) in a second group in whom the diagnosis was unknown. Speech delay and learning difficulties were almost universal and variable behavioral problems frequent...
November 2016: American Journal of Medical Genetics. Part A
Jessica Cohen, Ginger Golub, Margaret E Kruk, Margaret McConnell
Despite poverty and limited access to health care, evidence is growing that patients in low-income countries are taking a more active role in their selection of health care providers. Urban areas such as Nairobi, Kenya offer a rich context for studying these "active" patients because of the large number of heterogeneous providers available. We use a unique panel dataset from 2015 in which 402 pregnant women from peri-urban (the "slums" of) Nairobi, Kenya were interviewed three times over the course of their pregnancy and delivery, allowing us to follow women's care decisions and their perceptions of the quality of care they received...
September 22, 2016: Preventive Medicine
Gail McConnell, Johanna Trägårdh, Rumelo Amor, John Dempster, Es Reid, William Bradshaw Amos
Current optical microscope objectives of low magnification have low numerical aperture and therefore have too little depth resolution and discrimination to perform well in confocal and nonlinear microscopy. This is a serious limitation in important areas, including the phenotypic screening of human genes in transgenic mice by study of embryos undergoing advanced organogenesis. We have built an optical lens system for 3D imaging of objects up to 6 mm wide and 3 mm thick with depth resolution of only a few microns instead of the tens of microns currently attained, allowing sub-cellular detail to be resolved throughout the volume...
2016: ELife
Alicia M McConnell, Bindu Konda, David G Kirsch, Barry R Stripp
Exposure to high-linear energy transfer (LET) radiation occurs in a variety of situations, including charged particle radiotherapy, radiological accidents, and space travel. However, the extent of normal tissue injury in the lungs following high-LET radiation exposure is unknown. Here we show that exposure to high-LET radiation led to a prolonged loss of in vitro colony forming ability by airway epithelial progenitor cells. Furthermore, exposure to high-LET radiation induced clonal expansion of a subset of progenitor cells in the distal airway epithelium...
2016: Scientific Reports
Steve Varvel, Joseph P McConnell, Sotirios Tsimikas
OBJECTIVE: Elevated lipoprotein(a) [Lp(a)] is a causal, independent risk factor for cardiovascular disease and aortic stenosis. We aimed to define the prevalence and patient thresholds of elevated Lp(a) levels in the United States. APPROACH AND RESULTS: We analyzed Lp(a) levels in 532 359 subjects from 2 data sets: (1) in 531 144 subjects from a referral laboratory and (2) in 915 patients from a tertiary referral center. Lp(a) mass levels were measured by immunoturbidometric assays in both centers and expressed as mg/dL...
September 22, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Richard Sheu, Daniel Cormican, Matthew McConnell
No abstract text is available yet for this article.
October 2016: Journal of Cardiothoracic and Vascular Anesthesia
Anna Marie Chang, Amber Lin, Rongwei Fu, K John McConnell, Benjamin Sun
OBJECTIVE: The Institute of Medicine identified emergency department (ED) crowding as a critical threat to patient safety. We assess the association between changes in publicly reported ED length-of-stay (LOS) and changes in quality-of-care measures in a national cohort of hospitals. METHODS: Longitudinal analysis of 2012 and 2013 data from the American Hospital Association (AHA) Survey, Center for Medicare and Medicaid Services (CMS) Cost Reports, and CMS Hospital Compare...
September 19, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Christina Jeon, Keum Ji Jung, Heejin Kimm, Sungkyu Lee, Jessica L Barrington-Trimis, Rob McConnell, Jonathan M Samet, Sun Ha Jee
OBJECTIVE: To examine risk factors associated with use of e-cigarettes only, conventional cigarettes only, and dual use in Korean adolescents and young adults. METHODS: In a cross-sectional study, anonymous questionnaires were completed between April-May, 2015 among 1) 2744 middle and high school students, aged 13-18, from Seoul, Incheon, Gyeonggi, and Cheongju, Korea and 2) 2167 university students, aged 19-29, from fourteen universities in Korea. RESULTS: The results show that 12...
September 5, 2016: Drug and Alcohol Dependence
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