Junxiong Chen, Yingjun Ding, Chao Jiang, Rongmei Qu, Jonathan D Wren, Constantin Georgescu, Xuejun Wang, Darlene N Reuter, Beibei Liu, Cory B Giles, Christoph H Mayr, Herbert B Schiller, Jingxing Dai, Christopher S Stipp, Bharathiraja Subramaniyan, Jie Wang, Houjuan Zuo, Chao Huang, Kar-Ming Fung, Heather C Rice, Arnoud Sonnenberg, David Wu, Matthew S Walters, You-Yang Zhao, Tomoharu Kanie, Franklin A Hays, James F Papin, Dao Wen Wang, Xin A Zhang
BACKGROUND: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown. METHODS: In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events. RESULTS: Endothelial ablation of Cd151 leads to pulmonary and cardiac inflammation, severe sepsis, and perilous COVID-19, and endothelial CD151 becomes downregulated in inflammation...
April 1, 2024: Circulation Research