keyword
MENU ▼
Read by QxMD icon Read
search

D-amphetamine

keyword
https://www.readbyqxmd.com/read/29792471/sex-differences-in-the-anorexigenic-effects-of-dexfenfluramine-and-amphetamine-in-baboons
#1
Richard W Foltin, Suzette M Evans
The anorexigenic effects of intramuscular d-amphetamine HCl (0.06-0.50 mg/kg) and dexfenfluramine HCl (0.25-2.0 mg/kg) were determined in experimentally naïve baboons. A group of 8 adult male baboons was tested prior to a group of 7 adult female baboons. A 120-min session occurred at 9:00 a.m. during which baboons could respond for food pellets. Drug was given 30 min prior to the 9:00 a.m. morning session. Beginning at 11:00 a.m., baboons had a 6-hr multiple-meal session during which they could have up to 4 food pellet meals...
May 24, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29782943/effects-of-d-amphetamine-on-risk-choice-in-rats-depend-on-the-manner-in-which-the-expected-reward-value-is-varied
#2
Jen-Hau Yang, Chung-Ping Cheng, Ruey-Ming Liao
Decision making related to risks and rewards has been studied in the rodent by using several behavioral tests including the use of probability discounting tasks. However, it still remains unclear how long-term values and the different levels of risk are involved in decisions with reward uncertainty. In this study, we used a T-maze choice task to investigate the role of expected reward values in decision making under risk in the rat. The task was specifically set up to run with the expected value (EV) being equal to 1 between binary choice options (small-and-certain vs...
May 18, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29778625/the-mediating-role-of-phosphodiesterase-type-4-in-the-dopaminergic-modulation-of-motor-impulsivity
#3
P R A Heckman, A Blokland, N P Van Goethem, B T J Van Hagen, J Prickaerts
The current study investigated the mediating role of phosphodiesterase type 4 (PDE4) regulated cAMP in the dopaminergic modulation of premature responding (action restraint) in rats. Response inhibition, which includes action restraint, finds its neurobiological origin in cortico-striatal-thalamic circuitry and can be modulated by dopamine. Intracellularly, the effect of dopamine is largely mediated through the cAMP/PKA signaling cascade. Areas in the prefrontal cortex are very sensitive to their neurochemical environment, including catecholamine levels...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29770212/adolescent-thc-exposure-does-not-sensitize-conditioned-place-preferences-to-subthreshold-d-amphetamine-in-male-and-female-rats
#4
Robin J Keeley, Cameron Bye, Jan Trow, Robert J McDonald
The acute effects of marijuana consumption on brain physiology and behaviour are well documented, but the long-term effects of its chronic use are less well known. Chronic marijuana use during adolescence is of increased interest, given that the majority of individuals first use marijuana during this developmental stage , and  adolescent marijuana use is thought to increase the susceptibility to abusing other drugs when exposed later in life. It is possible that marijuana use during critical periods in adolescence could lead to increased sensitivity to other drugs of abuse later on...
2018: F1000Research
https://www.readbyqxmd.com/read/29749024/determining-the-effects-of-adulterants-on-drug-detection-via-elisa-and-adulterant-tests-strips
#5
Bianca Olivieri, Mark Marić, Candice Bridge
The use of immunoassays for drug screening has increased due to their sensitivity towards target analytes, specifically the enzyme linked immunosorbent assay (ELISA) technique. Adulterant test strips are commonly used in conjunction with immunoassay tests to ensure that the integrity of the specimen has not been altered prior to drug screening. This research focuses on determining which adulterants can produce a false negative result, not only with one of the screening tests, but throughout the entire screening process...
May 10, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29729640/determination-of-d-amphetamine-and-diphenhydramine-in-beagle-dog-plasma-by-a-96-well-formatted-liquid-liquid-extraction-and-capillary-zone-electrophoresis-with-field-amplified-sample-stacking
#6
Ji Li, Lingli Zhang, Xianliang Cheng, Lei Zhang, Baochun Shen, Chen Qing, Guorong Fan
This paper describes a method for quantification of d-amphetamine and diphenhydramine in beagle dog plasma by organic solvent field-amplified sample stacking (FASS)-capillary zone electrophoresis (CZE), using amlodipine as the internal standard. The separation was carried out at 25 °C in a 40.2 cm × 75 μm fused-silica capillary with an applied voltage of 20 kV using 25 mM phosphate-18.75 mM borate (pH 3.5). The detection wavelength was 200 nm. Clean-up and preconcentration of plasma biosamples were developed by 96-well formatted liquid- liquid extraction (LLE)...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29670821/amphetamine-but-not-methylphenidate-increases-ethanol-intake-in-adolescent-male-but-not-in-female-rats
#7
Paul Ruiz, Aldo Calliari, Patricia Genovese, Cecilia Scorza, Ricardo Marcos Pautassi
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40)...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29596148/personalized-n-of-1-trials-for-depression-a-systematic-review
#8
Ian M Kronish, Meghan Hampsey, Louise Falzon, Beatrice Konrad, Karina W Davidson
PURPOSE/BACKGROUND: Personalized (N-of-1) trials are single-patient, crossover-design trials that may be useful for personalizing the selection of depression treatments. We conducted a systematic review of published N-of-1 trials for depression to determine the feasibility and suitability of this methodology for personalizing depression care. METHODS/PROCEDURES: Electronic databases were searched from database inception through October 2016. Studies were selected if they enrolled depressed patients, included a within-subject crossover design, and systematically assessed depressive symptoms during the N-of-1 trial...
June 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29581536/neural-activation-to-monetary-reward-is-associated-with-amphetamine-reward-sensitivity
#9
Natania A Crane, Stephanie M Gorka, Jessica Weafer, Scott A Langenecker, Harriet de Wit, K Luan Phan
One known risk factor for drug use and abuse is sensitivity to rewarding effects of drugs. It is not known whether this risk factor extends to sensitivity to non-drug rewards. In this study with healthy young adults, we examined the association between sensitivity to the subjective rewarding effects of amphetamine and a neural indicator of anticipation of monetary reward. We hypothesized that greater euphorigenic response to amphetamine would be associated with greater neural activation to anticipation of monetary reward (Win > Loss)...
March 14, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29511807/acute-effects-of-lisdexamfetamine-and-d-amphetamine-on-social-cognition-and-cognitive-performance-in-a-placebo-controlled-study-in-healthy-subjects
#10
Patrick C Dolder, Petra Strajhar, Patrick Vizeli, Alex Odermatt, Matthias E Liechti
RATIONALE: Amphetamines are used as medications but are also misused as cognitive enhancers by healthy subjects and may have additional effects on social cognition. METHODS: We investigated the acute effects of single, high, equimolar doses of D-amphetamine (40 mg) and lisdexamfetamine (100 mg) on social cognition and cognitive performance using a randomized, placebo-controlled, double-blind, cross-over design in 24 healthy volunteers. Effects on social cognition were assessed using the Facial Emotion Recognition Task (FERT), Multifaceted Empathy Test (MET), and Sexual Arousal Task (SAT)...
May 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29511334/psychostimulant-drug-effects-on-glutamate-glx-and-creatine-in-the-anterior-cingulate-cortex-and-subjective-response-in-healthy-humans
#11
Tara L White, Mollie A Monnig, Edward G Walsh, Adam Z Nitenson, Ashley D Harris, Ronald A Cohen, Eric C Porges, Adam J Woods, Damon G Lamb, Chelsea A Boyd, Sinda Fekir
Prescription psychostimulants produce rapid changes in mood, energy, and attention. These drugs are widely used and abused. However, their effects in human neocortex on glutamate and glutamine (pooled as Glx), and key neurometabolites such as N-acetylaspartate (tNAA), creatine (tCr), choline (Cho), and myo-inositol (Ins) are poorly understood. Changes in these compounds could inform the mechanism of action of psychostimulant drugs and their abuse potential in humans. We investigated the acute impact of two FDA-approved psychostimulant drugs on neurometabolites using magnetic resonance spectroscopy (1 H MRS)...
June 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29427080/amphetamine-primes-enhanced-motivation-toward-uncertain-choices-in-rats-with-genetic-alcohol-preference
#12
Ville Oinio, Mikko Sundström, Pia Bäckström, Johanna Uhari-Väänänen, Kalervo Kiianmaa, Atso Raasmaja, Petteri Piepponen
RATIONALE: Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE: The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior. METHODS: In this study, Alko alcohol (AA) and Wistar rats went through long periods of operant lever pressing training where the task was to choose the profitable of two options...
May 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29413527/the-role-of-serine-racemase-in-the-pathophysiology-of-brain-disorders
#13
Joseph T Coyle, Darrick T Balu
The N-methyl-d-aspartate receptor (NMDAR) is unique in requiring two agonists to bind simultaneously to open its cation channel: the neurotransmitter, glutamate, and the coagonists, glycine, or d-serine. The Snyder laboratory was the first to clone serine racemase (SR), the enzyme that synthesizes d-serine, and to localize it immunocytochemically. Our laboratory has focused on the role of d-serine in brain disorders. Silencing the expression of SR, a risk gene for schizophrenia (SCZ), in mice (SR-/-), results in a phenotype that closely resembles SCZ including: cortical atrophy, reduced dendritic spine density and complexity, downregulation of parvalbumin-positive cortical GABAergic neurons, and cognitive impairments...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29389167/adolescent-d-amphetamine-exposure-enhances-the-acquisition-of-cocaine-self-administration-in-male-and-female-rats
#14
Ryan T Lacy, Hannah K Schorsch, Bridget P Austin
Diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD) has risen drastically over the past 20 years in the United States and abroad. Amphetamine-based prescription stimulants are the most prescribed treatment for ADHD and the diversion of these drugs has also increased. Reports indicate 61% of individuals with an ADHD medication prescription have sold or shared their medication. Exposure to prescription stimulants, especially for those without an ADHD diagnosis, may increase susceptibility to drugs of abuse...
February 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29355511/low-dose-d-amphetamine-induced-regression-of-liver-fat-deposits-in-dercum-disease
#15
Sehem Ghazala, Jawad Bilal, Elle Ross, Irbaz Bin Riaz, Bobby Kalb, Karen L Herbst
BACKGROUND: Dercum disease is a rare disorder of painful subcutaneous adipose tissue masses typically presenting as a constellation of signs and symptoms affecting most organs, including slow lymphatic flow and fatty liver. METHOD: The University of Arizona Institutional Review Board considered this report exempt after patient consent. Multislice, multisequence magnetic resonance imaging (MRI) of the abdomen and pelvis was performed prior to and after d-amphetamine, with and without intravenous gadolinium...
January 31, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29338486/rewarding-effects-of-physical-activity-predict-sensitivity-to-the-acute-subjective-effects-of-d-amphetamine-in-healthy-volunteers
#16
Mollie S Pester, Matthew G Kirkpatrick, Bree A Geary, Adam M Leventhal
While individual differences in reward sensitivity are believed to generalize across drugs and alternative rewards, this notion has received little empirical attention in human research. Here, we tested whether individual differences in the subjective rewarding effects of physical activity were associated with the subjective response to d-amphetamine administration. Healthy volunteers ( n=95; age 18-35 years) completed questionnaires measuring the self-reported pleasurable effects of physical activity and other covariates, and this was followed by two double-blind counterbalanced sessions during which they received either 20 mg oral d-amphetamine or placebo...
March 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29325847/amphetamine-induced-striatal-dopamine-release-measured-with-an-agonist-radiotracer-in-schizophrenia
#17
W Gordon Frankle, Jennifer Paris, Michael Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran
BACKGROUND: Receptor imaging studies have reported increased amphetamine-induced dopamine release in subjects with schizophrenia (SCH) relative to healthy control subjects (HCs). A limitation of these studies, performed with D2/3 antagonist radiotracers, is the failure to provide information about D2/3 receptors configured in a state of high affinity for the agonists (i.e., D2/3 receptors coupled to G proteins [D2/3 HIGH ]). The endogenous agonist dopamine binds with preference to D2/3 HIGH receptors relative to D2/3 LOW receptors, making it critical to understand the status of D2/3 HIGH receptors in SCH...
April 15, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29314376/validation-of-a-behavioral-economic-purchase-task-for-assessing-drug-abuse-liability
#18
James MacKillop, Nicholas I Goldenson, Matthew G Kirkpatrick, Adam M Leventhal
Behavioral economic purchase tasks quantify drug demand (i.e. reinforcing value of a drug) and have been used extensively to assess the value of various drugs among current users. However, purchase tasks have been rarely used with unfamiliar drugs to address a compound's abuse liability, and the current study sought to validate the paradigm in this capacity. Using a double-blind placebo-controlled within-subjects drug challenge design, the study evaluated differential drug demand on an experimental drug purchase task for a 20 mg dose of oral D-amphetamine (versus placebo), a prototypic psychostimulant, in 98 stimulant-naïve participants...
January 5, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29258368/lisdexamfetamine-chemistry-pharmacodynamics-pharmacokinetics-and-clinical-efficacy-safety-and-tolerability-in-the-treatment-of-binge-eating-disorder
#19
REVIEW
Kristen Ward, Leslie Citrome
The indications for lisdexamfetamine (LDX), a central nervous system stimulant, were recently expanded to include treatment of moderate to severe binge eating disorder (BED). Areas covered: This review aims to describe the chemistry and pharmacology of LDX, as well as the clinical trials investigating the efficacy and safety of this medication for the management of BED. Expert opinion: LDX is the first medication with United States Food and Drug Administration approval for the treatment of BED. It is an inactive prodrug of d-amphetamine that extends the half-life of d-amphetamine to allow for once daily dosing...
February 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29236922/effects-of-n-acetylcysteine-on-amphetamine-induced-sensitization-in-mice
#20
Ana P Herrmann, Roberta Andrejew, Radharani Benvenutti, Clarissa S Gama, Elaine Elisabetsky
OBJECTIVE: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. METHODS: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg...
December 11, 2017: Revista Brasileira de Psiquiatria
keyword
keyword
91939
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"