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JOURNAL ARTICLE
Craig M Zaidman, Natalie L Goedeker, Amal A Aqul, Russell J Butterfield, Anne M Connolly, Ronald G Crystal, Kara E Godwin, Kan N Hor, Katherine D Mathews, Crystal M Proud, Elizabeth Kula Smyth, Aravindhan Veerapandiyan, Paul B Watkins, Jerry R Mendell
BACKGROUND: Duchenne muscular dystrophy (DMD) is a rare, degenerative, recessive X-linked neuromuscular disease. Mutations in the gene encoding dystrophin lead to the absence of functional dystrophin protein. Individuals living with DMD exhibit progressive muscle weakness resulting in loss of ambulation and limb function, respiratory insufficiency, and cardiomyopathy, with multiorgan involvement. Adeno-associated virus vector-mediated gene therapy designed to enable production of functional dystrophin protein is a new therapeutic strategy...
April 11, 2024: Journal of Neuromuscular Diseases
#22
JOURNAL ARTICLE
Shiliang Li, Zijun Chen, Kunsheng Li, Ziyue Zhang, Yan Zhou
OBJECTIVE: This study evaluates the effects of valve surgery on safety and cardiac function in patients with valvular heart disease complicated by pulmonary arterial hypertension (PAH), focusing on postoperative outcomes influenced by age, heart function grade, and PAH severity. METHODS: A retrospective analysis was conducted on 307 valve surgery patients from April 2017 to April 2022. The cohort had a mean age of 57.6 years, with 56.9% males, and was stratified by NYHA functional class II-IV...
April 12, 2024: Alternative Therapies in Health and Medicine
#23
JOURNAL ARTICLE
Ji-Yong Moon, Sang Hyuk Kim, Youlim Kim, Hyun Lee, Chin Kook Rhee, Seung Won Ra, Chang Youl Lee, Joo Hun Park, Yong Bum Park, Kwang Ha Yoo
BACKGROUND: A suboptimal peak inspiratory flow rate (PIFR) in dry-powder inhaler (DPI) users can lead to insufficient therapeutic effects in the treatment of chronic obstructive pulmonary disease (COPD). However, few data on the prevalence of and factors associated with suboptimal PIFR in Korean patients with COPD are available. METHODS: We conducted a cross-sectional study of patients with COPD who had been using DPIs for more than three months. PIFR was measured using an In-Check DIAL G16 device...
April 9, 2024: Pulmonary Pharmacology & Therapeutics
#24
Tomoaki Oda, Naoaki Tamura, Daisuke Yata, Ayako Oda-Kishimoto, Toshiya Itoh, Naohiro Kubota, Yasuyuki Suzuki, Naohiro Kanayama, Hiroaki Itoh
Amniotic fluid embolism (AFE) induces cardiopulmonary insufficiency with consumptive coagulopathy. Previous studies reported that refractory coagulopathy has already advanced at the onset of maternal cardiovascular and/or respiratory symptoms. However, when the consumption of coagulation factors starts during the clinical course, AFE remains to be elucidated. We report an intrapartum AFE case of consumptive coagulopathy before dyspnea with hypotension developing during urgent cesarean delivery that was revealed by non-reassuring fetal heart rate tracing...
March 2024: Curēus
#25
JOURNAL ARTICLE
Yuanfang Ren, Yanjun Li, Tyler J Loftus, Jeremy Balch, Kenneth L Abbott, Matthew M Ruppert, Ziyuan Guan, Benjamin Shickel, Parisa Rashidi, Tezcan Ozrazgat-Baslanti, Azra Bihorac
Using clustering analysis for early vital signs, unique patient phenotypes with distinct pathophysiological signatures and clinical outcomes may be revealed and support early clinical decision-making. Phenotyping using early vital signs has proven challenging, as vital signs are typically sampled sporadically. We proposed a novel, deep temporal interpolation and clustering network to simultaneously extract latent representations from irregularly sampled vital signs and derive phenotypes. Four distinct clusters were identified...
April 10, 2024: Scientific Reports
#26
JOURNAL ARTICLE
Ken-Ichiro Inoue
No abstract text is available yet for this article.
April 9, 2024: Internal Medicine
#27
REVIEW
James Manifield, Yousuf Chaudhry, Sally J Singh, Thomas J C Ward, Maxine E Whelan, Mark W Orme
BACKGROUND: The variety of innovations to traditional centre-based pulmonary rehabilitation (CBPR), including different modes of delivery and adjuncts, are likely to lead to differential responses in physical activity, sedentary behaviour and sleep. OBJECTIVES: To examine the relative effectiveness of different pulmonary rehabilitation-based interventions on physical activity, sedentary behaviour and sleep. METHODS: Randomised trials in chronic respiratory disease involving pulmonary rehabilitation-based interventions were systematically searched for...
April 30, 2024: European Respiratory Review: An Official Journal of the European Respiratory Society
#28
JOURNAL ARTICLE
Ohoud Aljuhani, Khalid Al Sulaiman, Ghazwa B Korayem, Ali F Altebainawi, Abdulrahman Alshaya, Majed Nahari, Khuzama Alsamnan, Munirah A Alkathiri, Bodoor S Al-Dosari, Abeer A Alenazi, Samiah Alsohimi, Lina I Alnajjar, Mashael Alfaifi, Nora AlQussair, Reem M Alanazi, Munirah F Alhmoud, Nadin L Alanazi, Hadeel Alkofide, Aljawharah M Alenezi, Ramesh Vishwakarma
BACKGROUNDS: Ketamine possesses analgesia, anti-inflammation, anticonvulsant, and neuroprotection properties. However, the evidence that supports its use in mechanically ventilated critically ill patients with COVID-19 is insufficient. The study's goal was to assess ketamine's effectiveness and safety in critically ill, mechanically ventilated (MV) patients with COVID-19. METHODS: Adult critically ill patients with COVID-19 were included in a multicenter retrospective-prospective cohort study...
May 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
#29
JOURNAL ARTICLE
Rakhat Akmatova, Malembe S Ebama, Sanjar Temirbekov, Venera Alymkulova, Dinara Otorbaeva
INTRODUCTION: Influenza, a globally significant respiratory illness with pandemic potential, affects around 1 billion individuals annually, leading to increased risk for severe illness and mortality. Despite recommendations from the WHO Strategic Advisory Group of Experts on Immunization (SAGE) and MoH prioritization, influenza vaccination coverage rate among HCWs in Kyrgyzstan remains low, ranging between 16 % and 46 % over the past five years. Understanding the Knowledge, Attitudes, and Practices (KAP) dynamics of HCWs regarding influenza vaccinations, both before and during the COVID-19 pandemic is crucial for refining national strategies and institutional approaches to enhance vaccination coverage rates in this important risk group...
April 9, 2024: Vaccine
#30
REVIEW
Sooyeon Kwon, Marc A Judson
When sarcoidosis needs treatment, pharmacotherapy is usually required. Although glucocorticoids work reliably and relatively quickly for sarcoidosis, these drugs are associated with numerous significant side effects. Such side effects are common in sarcoidosis patients, as the disease frequently has a chronic course and glucocorticoid treatment courses are often prolonged. For these reasons, corticosteroid-sparing and corticosteroid-replacing therapies are often required for sarcoidosis. Unfortunately, many healthcare providers who care for sarcoidosis patients are not familiar with the use of these agents...
February 22, 2024: Journal of Clinical Medicine
#31
REVIEW
Paweł Radkowski, Maciej Szewczyk, Klaudia Sztaba, Mariusz Kęska
Rheumatoid arthritis (RA) is a chronic connective tissue disease of immunological etiology. In the course of the disease, symptoms of the musculoskeletal system predominate, but other systems can also be affected. The disease may require long-term treatment, and patients often require surgery on damaged joints. Complications of the disease and drug interactions may contribute to difficulties in perioperative care; therefore, knowledge is required to provide appropriate care. When anesthetizing a patient with RA, we should pay special attention to preoperative evaluation, taking a medical history, risk of difficult intubation or cardiac incidents, respiratory insufficiency, and frequent pulmonary infections...
April 9, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#32
JOURNAL ARTICLE
Yen-Liang Yeh, Chien-Ming Lai, Hui-Pu Liu
BACKGROUND: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are associated with unfavorable outcomes following coronary artery bypass grafting (CABG). The purpose of this study was to compare in-hospital outcomes of patients with COPD alone versus OSA-COPD overlap after CABG. METHODS: Data of adults ≥ 18 years old with COPD who received elective CABG between 2005 and 2018 were extracted from the US Nationwide Inpatient Sample (NIS)...
April 8, 2024: BMC Pulmonary Medicine
#33
A Reghan Foley, Véronique Bolduc, Fady Guirguis, Sandra Donkervoort, Ying Hu, Rotem Orbach, Riley M McCarty, Apurva Sarathy, Gina Norato, Beryl B Cummings, Monkol Lek, Anna Sarkozy, Russell J Butterfield, Janbernd Kirschner, Andrés Nascimento, Daniel Natera-de Benito, Susana Quijano-Roy, Tanya Stojkovic, Luciano Merlini, Giacomo Comi, Monique Ryan, Denise McDonald, Pinki Munot, Grace Yoon, Edward Leung, Erika Finanger, Meganne E Leach, James Collins, Cuixia Tian, Payam Mohassel, Sarah B Neuhaus, Dimah Saade, Benjamin T Cocanougher, Mary-Lynn Chu, Mena Scavina, Carla Grosmann, Randal Richardson, Brian D Kossak, Sidney M Gospe, Vikram Bhise, Gita Taurina, Baiba Lace, Monica Troncoso, Mordechai Shohat, Adel Shalata, Sophelia H S Chan, Manu Jokela, Johanna Palmio, Göknur Haliloğlu, Cristina Jou, Corine Gartioux, Herimela Solomon-Degefa, Carolin D Freiburg, Alvise Schiavinato, Haiyan Zhou, Sara Aguti, Yoram Nevo, Ichizo Nishino, Cecilia Jimenez-Mallebrera, Shireen R Lamandé, Valérie Allamand, Francesca Gualandi, Alessandra Ferlini, Daniel G MacArthur, Steve D Wilton, Raimund Wagener, Enrico Bertini, Francesco Muntoni, Carsten G Bönnemann
Collagen VI-related dystrophies (COL6-RDs) manifest with a spectrum of clinical phenotypes, ranging from Ullrich congenital muscular dystrophy (UCMD), presenting with prominent congenital symptoms and characterised by progressive muscle weakness, joint contractures and respiratory insufficiency, to Bethlem muscular dystrophy, with milder symptoms typically recognised later and at times resembling a limb girdle muscular dystrophy, and intermediate phenotypes falling between UCMD and Bethlem muscular dystrophy...
March 29, 2024: medRxiv
#34
JOURNAL ARTICLE
Qian He, Song Hu, Jun Xie, Yunqi Ge, Chong Li
BACKGROUND: Vitamin D is a crucial fat-soluble vitamin that has garnered significant attention due to its potential impact on respiratory health. It is noteworthy that many patients with chronic obstructive pulmonary disease (COPD) often experience deficiencies or insufficiencies of vitamin D. To address this issue, our retrospective study aimed to explore the potential association between serum 25-hydroxyvitamin D concentration and the prognoses of COPD patients in the Intensive Care Unit (ICU)...
2024: Frontiers in Medicine
#35
JOURNAL ARTICLE
Awada Lina, Hamilton Keith, Hutchison Jenny, Marrana Mariana, Torres Gregorio, Weber-Vintzel Laure, Tizzani Paolo
AIMS: Current data suggest that SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) emerged from an animal source. However, to date, there is insufficient scientific evidence to identify the source of SARS-CoV-2 or to explain the original route of transmission to humans. A wide range of mammalian species have been shown to be susceptible to the virus through experimental infection, and in natural environments when in contact with infected humans. The main objective of this work was to provide a summary of the official data shared by countries on SARS-CoV-2 in animals with the World Organisation for Animal Health (WOAH), to highlight the role of WOAH as an international organization in coordinating scientific information actions and to discuss the implications and impact of these activities...
April 7, 2024: Zoonoses and Public Health
#36
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations...
April 3, 2024: Lancet
#37
JOURNAL ARTICLE
Liliana Fernandez-Trujillo, Saveria Sangiovanni, Ana Isabel Castrillon, Lina Hincapie-Zapata, Lina Maria Góez-Mogollón, Marcela Brun Vergara, Sergio I Prada
PURPOSE: This study examines the financial impact of the COVID-19 pandemic on the Colombian Health System, focusing on the adequacy of reimbursement rates for inpatient stays. The study, based on a cost of illness analysis, aims to evaluate the effectiveness of the reimbursement scheme and identify potential economic losses within the health system. PATIENTS AND METHODS: The study protocol outlines the inclusion criteria for patients >18 years with confirmed COVID-19 infection and moderate to critical disease...
April 5, 2024: BMJ Open Respiratory Research
#38
JOURNAL ARTICLE
Xingru Zhao, Haonan Kang, Yunxia An, Zhiwei Xu, Meihui Wei, Quncheng Zhang, Linqi Diao, Zhiping Guo, Xiaoju Zhang
BACKGROUND: Despite substantial progress in reducing the global burden of chronic obstructive pulmonary disease (COPD), traditional methods to promote understanding and management of COPD are insufficient. We developed an innovative model based on the internet of things (IoT) for screening and management of COPD in primary healthcare (PHC). METHODS: Electronic questionnaire and IoT-based spirometer were used to screen residents. We defined individuals with a questionnaire score of 16 or higher as high-risk population, COPD was diagnosed according to 2021 Global Initiative for COPD (Global Initiative for Chronic Obstructive Lung Disease) criteria...
April 5, 2024: BMJ Open Respiratory Research
#39
JOURNAL ARTICLE
Bikram Poudel, Kiran Paudel, Bikram Adhikari, Rajan Paudel, Sandesh Bhusal, Nabin Adhikari, Tara Ballav Adhikari, Vishnu Prasad Sapkota, Roman Shrestha
Four noncommunicable diseases (NCDs): cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes, account for 71% of global deaths. However, little is known about the NCDs risk profile of sexual and gender minorities (SGMs). This study aimed to determine the prevalence of NCDs risk factors among the SGMs of Kathmandu valley, Nepal. A cross-sectional study was conducted among SGMs in the Kathmandu valley, Nepal. We recruited 140 participants using the snowball sampling method. A face-to-face interview was done using a structured questionnaire adapted from World Health Organization Step Wise Approach to Surveillance (STEPS instruments V2...
April 5, 2024: Medicine (Baltimore)
#40
JOURNAL ARTICLE
Denis Peruzzo, Tommaso Ciceri, Sara Mascheretti, Valentina Lampis, Filippo Arrigoni, Nivedita Agarwal, Alice Giubergia, Filippo Maria Villa, Alessandro Crippa, Maria Nobile, Elisa Mani, Annamaria Russo, Maria Grazia D'Angelo
BACKGROUND: Duchenne Muscular Dystrophy (DMD) is a genetic disease in which lack of the dystrophin protein causes progressive muscular weakness, cardiomyopathy and respiratory insufficiency. DMD is often associated with other cognitive and behavioral impairments, however the correlation of abnormal dystrophin expression in the central nervous system with brain structure and functioning remains still unclear. OBJECTIVE: To investigate brain involvement in patients with DMD through a multimodal and multivariate approach accounting for potential comorbidities...
April 5, 2024: Journal of Neuromuscular Diseases
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