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https://www.readbyqxmd.com/read/29230166/the-therapeutic-potential-of-monocyte-macrophage-manipulation-in-the-treatment-of-chemotherapy-induced-painful-neuropathy
#1
REVIEW
Karli Montague, Marzia Malcangio
In cancer treatments a dose-limiting side-effect of chemotherapeutic agents is the development of neuropathic pain, which is poorly managed by clinically available drugs at present. Chemotherapy-induced painful neuropathy (CIPN) is a major cause of premature cessation of treatment and so a greater understanding of the underlying mechanisms and the development of novel, more effective therapies, is greatly needed. In some cases, only a weak correlation between chemotherapy-induced pain and neuronal damage is observed both clinically and preclinically...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29104823/record-breaking-achievements-by-spiders-and-the-scientists-who-study-them
#2
Stefano Mammola, Peter Michalik, Eileen A Hebets, Marco Isaia
Organismal biology has been steadily losing fashion in both formal education and scientific research. Simultaneous with this is an observable decrease in the connection between humans, their environment, and the organisms with which they share the planet. Nonetheless, we propose that organismal biology can facilitate scientific observation, discovery, research, and engagement, especially when the organisms of focus are ubiquitous and charismatic animals such as spiders. Despite being often feared, spiders are mysterious and intriguing, offering a useful foundation for the effective teaching and learning of scientific concepts and processes...
2017: PeerJ
https://www.readbyqxmd.com/read/29080511/influence-of-outdoor-running-fatigue-and-medial-tibial-stress-syndrome-on-accelerometer-based-loading-and-stability
#3
Kurt H Schütte, Stefan Seerden, Rachel Venter, Benedicte Vanwanseele
Medial tibial stress syndrome (MTSS) is a common overuse running injury with pathomechanics likely to be exaggerated by fatigue. Wearable accelerometry provides a novel alternative to assess biomechanical parameters continuously while running in more ecologically valid settings. The purpose of this study was to determine the influence of outdoor running fatigue and MTSS on both dynamic loading and dynamic stability derived from trunk and tibial accelerometery. Runners with (n=14) and without (n=16) history of MTSS performed an outdoor fatigue run of 3200m...
January 2018: Gait & Posture
https://www.readbyqxmd.com/read/29076961/six-sessions-of-sprint-interval-training-improves-running-performance-in-trained-athletes
#4
Jerome Koral, Dustin J Oranchuk, Roberto Herrera, Guillaume Y Millet
Sprint interval training (SIT) is gaining popularity with endurance athletes. Various studies have shown that SIT allows similar or greater endurance, strength, and power performance improvements than traditional endurance training, but demands less time and volume. One of the main limitations in SIT research is that most studies were performed in a laboratory using expensive treadmills or ergometers. The aim of this study was to assess the performance effects of a novel short term and highly accessible training protocol based on maximal shuttle runs in the field (SIT-F)...
October 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28932899/voluntary-running-enhanced-synaptic-plasticity-learning-and-memory-are-mediated-by-notch1-signal-pathway-in-c57bl-mice
#5
Xiaochen Zhang, Chunxiao Yang, Jing Gao, Hongqiang Yin, Hui Zhang, Tao Zhang, Zhuo Yang
It is well known that voluntary running can enhance synaptic plasticity and improve learning and memory abilities. The Notch1 receptor is also reported to be associated with these processes, but its role in running-induced alterations is unclear. In this study, we aimed to investigate whether the Notch1 signalling pathway was involved in voluntary running-induced enhancement of synaptic plasticity, learning and memory. Notch1 heterozygous deficient (Notch1(+/-)) mice and wildtype (WT) C57BL littermates were randomly divided into runner group and non-runner group...
September 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28901963/underlying-chronic-disease-medication-use-history-of-running-injuries-and-being-a-more-experienced-runner-are-independent-factors-associated-with-exercise-associated-muscle-cramping-a-cross-sectional-study-in-15778-distance-runners
#6
Martin P Schwellnus, Sonja Swanevelder, Esme Jordaan, Wayne Derman, Dina C Janse Van Rensburg
BACKGROUND: Exercise-associated muscle cramping (EAMC) is a significant medical complication in distance runners, yet factors associated with EAMC are poorly documented. OBJECTIVE: To document risk factors associated with EAMC in runners. DESIGN: Cross-sectional study. SETTING: Two ocean races (21.1 km, and 56 km). PARTICIPANTS: Fifteen thousand seven hundred seventy-eight race entrants. METHODS: Participants completed a prerace medical history screening tool including: training, cardiovascular disease (CVD), risk factors for, and symptoms of CVD, history of diseases affecting major organ systems, cancer, allergies, medication use, and running injury...
August 18, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28887210/can-half-marathon-affect-overall-health-the-yin-yang-of-sport
#7
Luca Dalle Carbonare, Marcello Manfredi, Giuseppe Caviglia, Eleonora Conte, Elisa Robotti, Emilio Marengo, Samuele Cheri, Francesco Zamboni, Daniele Gabbiani, Michela Deiana, Daniela Cecconi, Federico Schena, Monica Mottes, Maria Teresa Valenti
Physical activity improves overall health and counteracts metabolic pathologies. Adipose tissue and bone are important key targets of exercise; the prevalence of diseases associated with suboptimal physical activity levels has increased in recent times as a result of lifestyle changes. Mesenchymal stem cells (MSCs) differentiation in either osteogenic or adipogenic lineage is regulated by many factors. Particularly, the expression of master genes such as RUNX2 and PPARγ2 is essential for MSC commitment to osteogenic or adipogenic differentiation, respectively...
January 6, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/28790928/enhanced-right-chamber-remodeling-in-endurance-ultra-trail-athletes-compared-to-marathon-runners-detected-by-standard-and-speckle-tracking-echocardiography
#8
Kristian Ujka, Luca Bastiani, Gennaro D'Angelo, Bruna Catuzzo, Alessandro Tonacci, Simona Mrakic-Sposta, Alessandra Vezzoli, Guido Giardini, Lorenza Pratali
Background: Strenuous and endurance exercise training have been associated with morphological and functional heart remodeling. Two-dimensional speckle-tracking echocardiography (STE) is a novel technique that allows an accurate quantification of global myocardium deformation. Our aim was to evaluate together left and right cardiac remodeling in different long-distance running athletes: marathon runners (42 km) (M) and endurance mountain runners (>300 Km) (UT). Methods: A total of 92 athletes (70 males, 76%) including 47 M [age 45 ± 7 years; training: 18 (9-53) years(*)days/week], 45 UT [age 42 ± 9, training: 30 (15-66) years(*)days/week] underwent conventional echocardiography and STE (Beyond Diogenes 2...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28739221/structure-and-computation-in-immunoreagent-design-from-diagnostics-to-vaccines
#9
REVIEW
Louise Gourlay, Claudio Peri, Martino Bolognesi, Giorgio Colombo
Novel immunological tools for efficient diagnosis and treatment of emerging infections are urgently required. Advances in the diagnostic and vaccine development fields are continuously progressing, with reverse vaccinology and structural vaccinology (SV) methods for antigen identification and structure-based antigen (re)design playing increasingly relevant roles. SV, in particular, is predicted to be the front-runner in the future development of diagnostics and vaccines targeting challenging diseases such as AIDS and cancer...
December 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28604051/safe-or-out-does-the-location-of-attention-affect-judgments-at-first-base-in-baseball
#10
Ralph S Redden, Ghislain d'Entremont, Raymond M Klein
Titchener's law of prior entry states that attended stimuli are perceived before unattended stimuli. Prior entry effects measured with visual stimuli have been generated with both endogenous and exogenous attentional deployment (e.g., by Shore, Spence, & Klein, 2001). In theory, the endogenous form of prior entry may have implications for baseball umpire judgments. Conventionally, umpires are instructed to first attend to the ball when it is hit into play; however, where they attend at the imperative instant of the play at first base can vary between individuals and across scenarios...
June 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/28599003/measurement-agreement-between-a-newly-developed-sensing-insole-and-traditional-laboratory-based-method-for-footstrike-pattern-detection-in-runners
#11
Roy T H Cheung, Winko W An, Ivan P H Au, Janet H Zhang, Zoe Y S Chan, Alfred Man, Fannie O Y Lau, Melody K Y Lam, K K Lau, C Y Leung, N W Tsang, Louis K Y Sze, Gilbert W K Lam
This study introduced a novel but simple method to continuously measure footstrike patterns in runners using inexpensive force sensors. Two force sensing resistors were firmly affixed at the heel and second toe of both insoles to collect the time signal of foot contact. A total of 109 healthy young adults (42 males and 67 females) were recruited in this study. They ran on an instrumented treadmill at 0°, +10°, and -10° inclinations and attempted rearfoot, midfoot, and forefoot landings using real time visual biofeedback...
2017: PloS One
https://www.readbyqxmd.com/read/28424267/using-a-novel-data-resource-to-explore-heart-rate-during-mountain-and-road-running
#12
Andrew Best, Barry Braun
Online, accessible performance and heart rate data from running competitions are posted publicly or semi-publicly to social media. We tested the efficacy of one such data resource- Strava- as a tool in exercise physiology investigations by exploring heart rate differences in mountain racing and road racing running events. Heart rate and GPS pace data were gathered from Strava activities posted by 111 males aged 21-49, from two mountain races (Mt. Washington Road Race and Pike's Peak Ascent) and two road race distances (half marathon and marathon)...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28388232/acute-responses-of-strength-and-running-mechanics-to-increasing-and-decreasing-pain-in-patients-with-patellofemoral-pain
#13
David M Bazett-Jones, Wendy Huddleston, Stephen Cobb, Kristian O'Connor, Jennifer E Earl-Boehm
CONTEXT:   Patellofemoral pain (PFP) is typically exacerbated by repetitive activities that load the patellofemoral joint, such as running. Understanding the mediating effects of changes in pain in individuals with PFP might inform injury progression, rehabilitation, or both. OBJECTIVE:   To investigate the effects of changing pain on muscular strength and running biomechanics in those with PFP. DESIGN:   Crossover study. SETTING:   University research laboratory...
May 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28263283/running-technique-is-an-important-component-of-running-economy-and-performance
#14
Jonathan P Folland, Sam J Allen, Matthew I Black, Joseph C Handsaker, Stephanie E Forrester
Despite an intuitive relationship between technique and both running economy (RE) and performance, and the diverse techniques used by runners to achieve forward locomotion, the objective importance of overall technique and the key components therein remain to be elucidated. PURPOSE: This study aimed to determine the relationship between individual and combined kinematic measures of technique with both RE and performance. METHODS: Ninety-seven endurance runners (47 females) of diverse competitive standards performed a discontinuous protocol of incremental treadmill running (4-min stages, 1-km·h increments)...
July 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28212265/variations-in-oxidative-stress-levels-in-3-days-follow-up-in-ultramarathon-mountain-race-athletes
#15
Ypatios Spanidis, Dimitrios Stagos, Marina Orfanou, Nikolaos Goutzourelas, David Bar-Or, Demetrios Spandidos, Demetrios Kouretas
Spanidis, Y, Stagos, D, Orfanou, M, Goutzourelas, N, Bar-or, D, Spandidos, D, and Kouretas, D. Variations in oxidative stress levels in 3 days follow-up in ultramarathon mountain race athletes. J Strength Cond Res 31(3): 582-594, 2017-The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultramarathon race of 103 km. Blood samples from 12 runners were collected prerace and 24, 48, and 72 hours postrace. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27812406/pacing-during-an-ultramarathon-running-event-in-hilly-terrain
#16
Hugo A Kerhervé, Tom Cole-Hunter, Aaron N Wiegand, Colin Solomon
PURPOSE: The dynamics of speed selection as a function of distance, or pacing, are used in recreational, competitive, and scientific research situations as an indirect measure of the psycho-physiological status of an individual. The purpose of this study was to determine pacing on level, uphill and downhill sections of participants in a long (>80 km) ultramarathon performed on trails in hilly terrain. METHODS: Fifteen ultramarathon runners competed in a  173 km event (five finished at  103 km) carrying a Global-Positioning System (GPS) device...
2016: PeerJ
https://www.readbyqxmd.com/read/27749685/pacing-ability-in-elite-runners-with-intellectual-impairment
#17
Debbie VAN Biesen, Florentina J Hettinga, Katina McCulloch, Yves C Vanlandewijck
PURPOSE: To understand how athletes invest their energy over a race, differences in pacing ability between athletes with and without intellectual impairment (II) were explored using a novel field test. METHODS: Well-trained runners (n = 67) participated in this study, including 34 runners with II (age = 24.4 ± 4.5 yr; IQ = 63.1 ± 7.7) and 33 runners without II (age = 31.4 ± 11.2 yr). The ability to perform at a preplanned submaximal pace was assessed. Two 400-m running trials were performed on an athletics track, with an individually standardized velocity...
March 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27637250/selection-age-and-exercise-dependence-of-skeletal-muscle-gene-expression-patterns-in-a-rat-model-of-metabolic-fitness
#18
Yu-Yu Ren, Lauren G Koch, Steven L Britton, Nathan R Qi, Mary K Treutelaar, Charles F Burant, Jun Z Li
Intrinsic aerobic exercise capacity can influence many complex traits including obesity and aging. To study this connection we established two rat lines by divergent selection of untrained aerobic capacity. After 32 generations the high capacity runners (HCR) and low capacity runners (LCR) differed in endurance running distance and body fat, blood glucose, other health indicators, and natural life span. To understand the interplay among genetic differences, chronological age, and acute exercise we performed microarray-based gene expression analyses in skeletal muscle with a 2×2×2 design to simultaneously compare HCR and LCR, old and young animals, and rest and exhaustion...
November 1, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27607302/a-new-footwear-technology-to-promote-non-heelstrike-landing-and-enhance-running-performance-fact-or-fad
#19
Janet H Zhang, Aislinn J C McPhail, Winko W An, Waqar M Naqvi, Daniel L H Chan, Ivan P H Au, Alvin T W Luk, Tony L Chen, Roy T H Cheung
This study sought to compare the kinetics and kinematics data in a group of habitual shod runners when running in traditional running shoes and newly designed minimalist shoes with lug platform. This novel footwear design claims to simulate barefoot running and reduce energy loss during impact. We compared footstrike angle (FSA), vertical average (VALR) and instantaneous (VILR) loading rates, energy loss and initial vertical stiffness between two shoe conditions. Runners demonstrated a decreased FSA while running in minimalist shoes with lug platform than traditional shoes (P = 0...
August 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27553989/novel-approach-to-analysing-large-data-sets-of-personal-sun-exposure-measurements
#20
Suzana M Blesić, Đorđe I Stratimirović, Jelena V Ajtić, Caradee Y Wright, Martin W Allen
Personal sun exposure measurements provide important information to guide the development of sun awareness and disease prevention campaigns. We assess the scaling properties of personal ultraviolet radiation (pUVR) sun exposure measurements using the wavelet transform (WT) spectral analysis to process long-range, high-frequency personal recordings collected by electronic UVR dosimeters designed to measure erythemal UVR exposure. We analysed the sun exposure recordings of school children, farmers, marathon runners and outdoor workers in South Africa, and construction workers and work site supervisors in New Zealand...
November 2016: Journal of Exposure Science & Environmental Epidemiology
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