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Intrathecal dexmedetomidine

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https://www.readbyqxmd.com/read/28435222/effects-of-intrathecal-dexmedetomidine-on-shivering-after-spinal-anesthesia-for-cesarean-section-a-double-blind-randomized-clinical-trial
#1
Karim Nasseri, Negin Ghadami, Bijan Nouri
BACKGROUND: Shivering is among the common troublesome complications of spinal anesthesia (SA), and causes discomfort and discontentment in parturients undergoing cesarean sections (CSs). The aim of this study was to investigate the effects of intrathecal dexmedetomidine in the prevention of shivering in those who underwent CS under SA. SUBJECTS AND METHODS: Fifty parturients planned for elective CSs under SA were enrolled in this prospective, double-blinded, controlled study and randomly divided into two equal groups...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28416997/comparison-of-intrathecal-versus-intra-articular-dexmedetomidine-as-an-adjuvant-to-bupivacaine-on-postoperative-pain-following-knee-arthroscopy-a-randomized-clinical-trial
#2
Eman A Ismail, Jehan A Sayed, Mohamed H Bakri, Reda Z Mahfouz
BACKGROUND: Postoperative pain is a common, distressing symptom following arthroscopic knee surgery. The aim of this study was to compare the potential analgesic effect of dexmedetomidine after intrathecal versus intra-articular administration following arthroscopic knee surgery. METHODS: Ninety patients undergoing unilateral elective arthroscopic knee surgery were randomly assigned into three groups in a double-blind placebo controlled study. The intrathecal dexmedetomidine group (IT) received an intrathecal block with intrathecal dexmedetomidine, the intra-articular group (IA) received an intrathecal block and intra-articular dexmedetomidine, and the control group received an intrathecal block and intra-articular saline...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28384962/comparison-of-intravenous-dexmedetomidine-with-midazolam-in-prolonging-spinal-anaesthesia-with-ropivacaine
#3
Balwinder Kaur Rekhi, Tejinderpal Kaur, Divya Arora, Pankaj Dugg
INTRODUCTION: Midazolam and dexmedetomidine both being sedatives, but the latter with additional analgesic properties is expected to prolong the duration of sensory and motor block obtained with spinal anaesthesia. AIM: To compare intravenous dexmedetomidine with midazolam and placebo with respect to sensory and motor block duration, analgesia, and sedation in patients undergoing lower limb and lower abdominal surgeries with intrathecal ropivacaine anaesthesia. MATERIALS AND METHODS: In this single blind placebo controlled trial, 60 patients, classified as American Society of Anaesthesiologists' (ASA) physical status I-II, were randomized into three groups (n=20 per group)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28302458/the-effects-of-dexmedetomidine-pretreatment-on-the-pro-and-anti-inflammation-systems-after-spinal-cord-injury-in-rats
#4
Hui Rong, Zhibin Zhao, Jiying Feng, Yishan Lei, Hao Wu, Rao Sun, Zuoxia Zhang, Bailing Hou, Wei Zhang, YuE Sun, Xiaoping Gu, Zhengliang Ma, Yue Liu
Excessive inflammatory responses play important roles in the aggravation of secondary damage to an injured spinal cord. Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist, has recently been implied to be neuroprotective in clinical anesthesia, but the underlying mechanism is elusive. As signaling through Toll-like receptor 4 (TLR4) and nicotinic receptors (nAChRs, notably α7nAChR) play important roles in the pro- and anti-inflammation systems in the central nervous system, respectively, this study investigated whether and how they were modulated by DEX pretreatment in a rat model of spinal cord compression...
March 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28298786/comparison-of-dexmedetomidine-and-magnesium-sulfate-as-adjuvants-with-ropivacaine-for-spinal-anesthesia-in-infraumbilical-surgeries-and-postoperative-analgesia
#5
Reena Makhni, Joginder Pal Attri, Payal Jain, Veena Chatrath
INTRODUCTION: Postoperative pain is a major cause of fear and anxiety in hospitalized patients and so if patients remain pain-free during this period, they can cooperate with the circumstances well, leading to early recovery. Over the last two decades, there has been considerable revival of interest in the use of regional anesthesia techniques for surgery and pain management. As very few studies have been conducted using ropivacaine with dexmedetomidine and magnesium sulfate (MgSO4) as adjuvants, the present study was undertaken with primary aims to compare the hemodynamic stability, onset and duration of sensory and motor block and with secondary aims of the postoperative analgesic effect of dexmedetomidine and MgSO4 along with ropivacaine...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28210917/adjuvant-agents-in-regional-anesthesia-in-the-ambulatory-setting
#6
REVIEW
Veerandra Koyyalamudi, Sudipta Sen, Shilpadevi Patil, Justin B Creel, Elyse M Cornett, Charles J Fox, Alan D Kaye
PURPOSE OF REVIEW: A majority of surgical practice has involved ambulatory centers with the number of outpatient operations in the USA doubling to 26.8 million per year. Local anesthesia delivery provides numerous benefits, including increased satisfaction, earlier discharge, and reduction in unplanned hospital admission. Further, with the epidemic of opioid mediated overdoses, local anesthesia can be a key tool in providing an opportunity to reduce the need for other analgesics postoperatively...
January 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28154256/intrathecal-dexmedetomidine-alleviates-shivering-during-cesarean-delivery-under-spinal-anesthesia
#7
RANDOMIZED CONTROLLED TRIAL
Liang He, Jun-Mei Xu, Su-Mei Liu, Zhi-Jun Chen, Xin Li, Rong Zhu
Shivering associated with spinal anesthesia during Cesarean delivery is an uncomfortable experience for the parturient, which may also cause adverse effects. In this prospective, randomized, double-blind, placebo-controlled study, we sought to evaluate the effect of intrathecal dexmedetomidine, administered as an adjunct to hyperbaric bupivacaine for Cesarean delivery, on the incidence and severity of shivering associated with spinal anesthesia. Patients undergoing Cesarean delivery were randomly allocated to three groups of 30 patients each...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27871236/the-timing-of-administration-of-intravenous-dexmedetomidine-during-lower-limb-surgery-a-randomized-controlled-trial
#8
Eunsu Kang, Ki Hwa Lee, Sang Yoon Jeon, Kyu Won Lee, Myoung Jin Ko, Hyojoong Kim, Yong Han Kim, Jae-Wook Jung
BACKGROUND: Dexmedetomidine, a selective alpha-2 agonist, has sedative, analgesic, and anxiolytic effects without respiratory depression. Dexmedetomidine can cause a biphasic cardiovascular response, and induce transient hypertension. Hypotension is a common complication of spinal anesthesia. Decreasing anxiety of patients before procedure is important for high quality of procedure. This study aimed to compare the incidence of hypotension and patients' anxiety and comfort levels when dexmedetomidine was intravenously administered before and after spinal anesthesia...
November 21, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27846112/effectiveness-of-intrathecal-dexmedetomidine-as-an-adjuvant-to-bupivacaine-spinal-anesthesia-in-adult-patients-undergoing-elective-surgery-a-systematic-review-protocol
#9
Stephanie Pierce, Laura Bonanno, Stephanie Sanvi
The current review aims to identify the effects of intrathecal dexmedetomidine as an adjuvant to bupivacaine spinal anesthesia compared to the sole use of bupivacaine spinal anesthesia alone in adult patients undergoing elective surgical procedures.
October 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27790558/intrathecal-dexmedetomidine-for-anaesthetic-management-of-a-patient-with-chronic-inflammatory-demyelinating-polyneuropathy
#10
S Bala Bhaskar, D Srinivasalu
Chronic demyelinating disorders have multifactorial origin but common important physiologic and anaesthetic considerations. Choice of anaesthesia technique and the drugs used, undertanding the pros and cons of using central neuraxial blocks will help in successful management of such patients. We describe the anaesthetic management of a 34-year-old male with chronic inflammatory demyelinating polyneuropathy posted for cystolithotripsy.
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27454273/intrathecal-dexmedetomidine-ketamine-and-their-combination-added-to-bupivacaine-for-postoperative-analgesia-in-major-abdominal-cancer-surgery
#11
Sahar Abd-Elbaky Mohamed, Ahmad Mohammad Abd El-Rahman, Khaled M Fares
BACKGROUND: Intrathecal ketamine has been studied extensively in animals, but rarely in humans. Intrathecal dexmedetomidine prolongs the duration of spinal anesthesia. OBJECTIVE: To investigate the efficacy and safety of intrathecal dexmedetomidine, ketamine, or both when added to bupivacaine for postoperative analgesia in major abdominal cancer surgery. DESIGN: Double-blinded, randomized, controlled trial. SETTING: Academic medical center...
July 2016: Pain Physician
https://www.readbyqxmd.com/read/27349272/comparison-of-intrathecal-dexmedetomidine-with-morphine-as-adjuvants-in-cesarean-sections
#12
RANDOMIZED CONTROLLED TRIAL
Xiaofei Qi, Daili Chen, Gehui Li, Xiaolei Huang, Yuantao Li, Xiaoguang Wang, Yong Li
To compare the effects of intrathecal dexmedetomidine and intrathecal morphine as supplements to bupivacaine in cesarean sections under spinal anesthesia. Full-term parturients (n=120) undergoing elective cesarean sections under spinal anesthesia were randomly allocated into three groups: Group B received 10 mg bupivacaine, Group BD received 10 mg bupivacaine plus 5 µg dexmedetomidine, and Group BM received 10 mg bupivacaine plus 100 µg morphine. The onset and regression time of sensory and motor blockade, postoperative analgesia, and side effects were recorded...
September 1, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27330198/comparative-evaluation-of-intrathecal-morphine-and-intrathecal-dexmedetomidine-in-patients-undergoing-gynaecological-surgeries-under-spinal-anaesthesia-a-prospective-randomised-double-blind-study
#13
Pranjali Kurhekar, S Madan Kumar, D Sampath
BACKGROUND AND AIMS: Inrathecal opioids like morphine added to local anaesthetic agents have been found to be effective in achieving prolonged post-operative analgesia. Intrathecal dexmedetomidine may be devoid of undesirable side effects related to morphine and hence, this study was designed to evaluate analgesic efficacy, haemodynamic stability and adverse effects of both these adjuvants in patients undergoing gynaecological surgeries. METHODS: This was a prospective, randomised, double blind study involving 25 patients in each group...
June 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27275052/dexmedetomidine-versus-midazolam-as-adjuvants-to-intrathecal-bupivacaine-a-clinical-comparison
#14
Usha Shukla, Tallamraju Prabhakar, Kiran Malhotra, Dheeraj Srivastava
BACKGROUND AND AIMS: Trials are being carried out to identify an adjuvant to intrathecal bupivacaine that preferably potentiates postoperative analgesia. This prospective, randomized, double-blind study was aimed to compare the onset and duration of sensory and motor block, postoperative analgesia and adverse effects of dexmedetomidine or midazolam given with 0.5% hyperbaric bupivacaine for spinal anesthesia. MATERIAL AND METHODS: A total of 80 patients, scheduled for vaginal hysterectomies, were randomly allocated to Group D (n = 40) to receive intrathecally 3...
April 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27212760/single-dose-intravenous-dexmedetomidine-prolongs-spinal-anesthesia-with-hyperbaric-bupivacaine
#15
Jyotsna Kubre, Ashish Sethi, Mamta Mahobia, Deeksha Bindal, Neeraj Narang, Anudeep Saxena
BACKGROUND AND INTRODUCTION: Spinal block, a known technique to obtain anaesthesia for infraumblical surgeries. Now physician have advantage of using adjuvant to prolong the effect of intrathecal block, which can be given either intravenously or intrathecally, dexmedetomidine is one of them. We studied effect of intravenous dexmedetomidine for prolongation of duration of intrathecal block of 0.5% bupivacaine block. OBJECTIVE: To evaluate the effect of intravenous dexmedetomidine on sensory regression, hemodynamic profile, level of sedation and postoperative analgesia...
May 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27190922/optimal-dose-of-intrathecal-dexmedetomidine-in-lower-abdominal-surgeries-in-average-indian-adult
#16
Shagufta Naaz, Jahanara Bandey, Erum Ozair, Adil Asghar
BACKGROUND: Dexmedetomidine, a selective alpha2 adrenoceptor agonist, has been used as adjuvant to spinal anaesthesia. AIM: To find out the optimum dose of dexmedetomidine to be used in lower abdomen surgery intrathecally. MATERIALS AND METHODS: This was a randomized, controlled, double blinded study which included adult ASA I and II patients. They were allocated into five groups (n=20). Patients allergic to drugs to be used in the study and those with co-existing neurological disorders, coagulopathies, cardiac diseases, obesity and hypertension were excluded...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27134975/evaluation-of-dexmedetomidine-as-an-adjuvant-to-intrathecal-bupivacaine-in-infraumbilical-surgeries
#17
Sisinti Sanjeeb Patro, Hemant Deshmukh, Yerramalli Roja Ramani, Gitanjali Das
INTRODUCTION: Various adjuvants like morphine, buprenorphine and fentanyl, clonidine, ketamine are being used in anaesthetic practice since long for improvement of peri-operative analgesia following spinal anaesthesia. Such adjuvants have been helpful in induction of early ambulation but at the cost of their associated adverse effects. Therefore search for an effective adjuvant is still going on. Currently Dexmedetomidine, a highly selective α2-adrenoreceptor agonist is being studied for its adjuvant action in spinal anaesthesia...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27110524/intrathecal-dexmedetomidine-and-fentanyl-as-adjuvant-to-bupivacaine-on-duration-of-spinal-block-in-addicted-patients
#18
Farhad Safari, Reza Aminnejad, Seyed Amir Mohajerani, Farshad Farivar, Kamran Mottaghi, Hasan Safdari
BACKGROUND: Addicted patients have innate tolerance to local anesthetics in both neuraxial and peripheral blocks. Dexmedetomidine (Dex) is a highly selective α2 adrenergic receptor agonist used as additive to increase quality and duration of peripheral nerve blocks. OBJECTIVES: The current study aimed to compare the effect of dexmedetomidine and fentanyl additives on bupivacaine to prolong the duration of block and minimizing side effects. PATIENTS AND METHODS: Patients were candidates for elective surgery less than three hours of lower abdomen or lower extremities surgeries...
February 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27008297/effect-of-3-different-doses-of-intrathecal-dexmedetomidine-2-5%C3%A2%C2%B5g-5%C3%A2%C2%B5g-and-10-%C3%A2%C2%B5g-on-subarachnoid-block-characteristics-a-prospective-randomized-double-blind-dose-response-trial
#19
RANDOMIZED CONTROLLED TRIAL
Mayank Gupta, Priyanka Gupta, Dhananjay Kumar Singh
BACKGROUND: The extended analgesic efficacy of intrathecal dexmedetomidine (ITD) has been investigated in a few clinical trials; however, there is a lack of conclusive evidence upon its ideal dosage. OBJECTIVES: To elucidate the dose-response relationship between ITD and subarachnoid block characteristics, particularly the duration of analgesia and differential analgesia (DA: defined as time difference from the offset of motor blockade to the first analgesic requirement on numerical rating scale = 4...
March 2016: Pain Physician
https://www.readbyqxmd.com/read/27002003/combined-intrathecal-morphine-and-dexmedetomidine-for-postoperative-analgesia-in-patients-undergoing-major-abdominal-cancer-surgery
#20
Hala Saad Abdel-Ghaffar, Sahar Abdel-Baky Mohamed, Khaled Mohamed Fares
OBJECTIVE: To compare the analgesic effect of combined intrathecal morphine and dexmedetomidine with either drug alone for postoperative analgesia in patients undergoing major abdominal cancer surgery. METHODS: Ninety patients were allocated to receive intrathecal 10 mg bupivacaine 0.5% (bupivacaine group, n = 30), 10 mg bupivacaine 0.5% and 0.5 mg morphine (Morphine Group, n = 30), or 10 mg bupivacaine 0.5%, 0.5 mg morphine and 5 µg dexmedetomidine (morphine-Dex group, n = 30)...
November 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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