Sophia Morel, Pauline Léveillé, Mariia Samoilenko, Anita Franco, Jade England, Nicolas Malaquin, Véronique Tu, Guillaume B Cardin, Simon Drouin, Francis Rodier, Sarah Lippé, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Geneviève Lefebvre, Emile Levy, Valérie Marcil
Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 ± 6.3 years; mean time since diagnosis, 15.5 ± 5.2 years) and evaluated the associations using a series of logistic regressions. Using structural equation models, we also tested if the relationship between endotoxemia and cardiometabolic complications was mediated by the latent (unobserved) variable inflammation inferred from the observed biomarkers CRP, TNF-α and IL-6...
December 9, 2020: Scientific Reports