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Respiratory adults and paediatric

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https://www.readbyqxmd.com/read/29912602/comparing-immunoglobulin-a-vasculitis-henoch-sch%C3%A3-nlein-purpura-in-children-and-adults-a-single-centre-study-from-turkey
#1
E D Batu, A Sarı, A Erden, H E Sönmez, B Armağan, U Kalyoncu, Ö Karadağ, Y Bilginer, A Akdoğan, S Kiraz, S Özen
OBJECTIVE: Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It is the most common primary systemic vasculitis of childhood and is much less common in adults. Our aim was to investigate the differences and similarities between adult and paediatric patients with IgAV/HSP. METHOD: We retrospectively evaluated the medical records of 35 adult and 159 paediatric (˂ 18 years old) patients with a clinical diagnosis of IgAV/HSP who were seen at the Departments of Rheumatology and Pediatric Rheumatology, Hacettepe University, Ankara, Turkey...
June 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29873433/respiratory-virus-detection-and-co-infection-in-children-and-adults-in-a-large-australian-hospital-in-2009-2015
#2
Natasha S Ching, Despina Kotsanas, Mee L Easton, Michelle J Francis, Tony M Korman, Jim P Buttery
AIM: This hospital network-based retrospective observational study aimed to describe the prevalence and seasonality of paediatric and adult viral respiratory pathogens and their rates of co-infections, following the introduction of a rapid multiplex molecular diagnostic assay. METHODS: All nasopharyngeal samples tested in patients presenting to Monash Health, Melbourne, Australia, from August 2009 to July 2015 by means of multiplex tandem polymerase chain reaction using the Respiratory Pathogen 12Plex kit (AusDiagnostics) were included in the analysis...
June 6, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29871899/myotonic-dystrophy-type-1-clinical-manifestations-in-children-and-adolescents
#3
Genevieve Ho, Kate A Carey, Michael Cardamone, Michelle A Farrar
OBJECTIVE: Myotonic dystrophy type 1 (DM1) is an autosomal-dominant neuromuscular disease with variable severity affecting all ages; however, current care guidelines are adult-focused. The objective of the present study was to profile DM1 in childhood and propose a framework to guide paediatric-focused management. DESIGN, SETTING AND PATIENTS: 40 children with DM1 (mean age 12.8 years; range 2-19) were studied retrospectively for a total of 513 follow-up years at Sydney Children's Hospital...
June 5, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29865934/tele-monitoring-in-paediatric-and-young-home-ventilated-neuromuscular-patients-a-multicentre-case-control-trial
#4
Federica Trucco, Marina Pedemonte, Fabrizio Racca, Raffaele Falsaperla, Catia Romano, Anette Wenzel, Alessia D'Agostino, Angela Pistorio, Paola Tacchetti, Cristina Bella, Claudio Bruno, Carlo Minetti
Introduction Tele-monitoring (TM) has proved effective in the home management of adult ventilator-dependent neuromuscular disease (NMD) patients. We aimed to evaluate a 2-year longitudinal multicentre TM trial designed for young ventilated NMD patients in terms of feasibility, home management of exacerbations and caregivers' burden. Methods The TM trial protocol included patients' weekly scheduled overnight home-recording of SpO2 , heart rate and ventilation and their transmission to each TM centre the following morning...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29802097/15-minute-consultation-using-point-of-care-ultrasound-to-assess-children-with-respiratory-failure
#5
Helen L Ord, Michael J Griksaitis
Point of care ultrasound (POCUS) is well established in adult emergency medicine and critical care. It is used for immediate diagnosis and evaluation of the impact of bedside interventions in the acutely unwell child. This article highlights how ultrasound can be helpful in paediatric practice when dealing with the neonate, infant or older child with undifferentiated respiratory distress, respiratory failure or ventilation problems. It highlights indications for use, key diagnostic features of common pathology and outlines the benefits of POCUS in everyday practice...
May 25, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29699897/development-of-regional-extracorporeal-life-support-system-the-importance-of-innovative-simulation-training
#6
Mateusz Puślecki, Marcin Ligowski, Marek Dąbrowski, Sebastian Stefaniak, Małgorzata Ładzińska, Aleksander Pawlak, Marcin Zieliński, Łukasz Szarpak, Bartłomiej Perek, Marek Jemielity
BACKGROUND: Despite advances in mechanical ventilation, severe acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality rates ranging from 30% to 60%. Extracorporeal Membrane Oxygenation (ECMO) can be used as a "bridge to recovery". ECMO is a complex network that provides oxygenation and ventilation and allows the lungs to rest and recover from respiratory failure, while minimizing iatrogenic ventilator-induced lung injury. In the critical care settings, ECMO is shown to improve survival rates and outcomes in patients with severe ARDS...
April 18, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29652167/computational-phantoms-icrp-icru-and-further-developments
#7
M Zankl, J Becker, C Lee, W E Bolch, Y S Yeom, C H Kim
Phantoms simulating the human body play a central role in radiation dosimetry. The first computational body phantoms were based upon mathematical expressions describing idealised body organs. With the advent of more powerful computers in the 1980s, voxel phantoms have been developed. Being based on three-dimensional images of individuals, they offer a more realistic anatomy. Hence, the International Commission on Radiological Protection (ICRP) decided to construct voxel phantoms representative of the adult Reference Male and Reference Female for the update of organ dose coefficients...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29621601/results-from-the-third-scottish-national-prevalence-survey-is-a-population-health-approach-now-needed-to-prevent-healthcare-associated-infections
#8
S Cairns, C Gibbons, A Milne, H King, M Llano, L MacDonald, W Malcolm, C Robertson, J Sneddon, J Weir, J Reilly
BACKGROUND: Healthcare-associated infections (HCAIs) are a major public health concern and a significant cause of morbidity and mortality. A robust and current evidence base that is specific to local, national and Europe-wide settings is necessary to inform the development of strategies to reduce HCAI and contain antimicrobial resistance. AIM: To measure the prevalence of HCAI and antimicrobial prescribing and identify key priority areas for interventions to reduce the burden of infection...
April 2, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29605009/troglostrongylus-brevior-a-feline-lungworm-of-paediatric-concern
#9
Maria Alfonsa Cavalera, Roberta Iatta, Vito Colella, Filipe Dantas-Torres, Angelo Corsaro, Emanuele Brianti, Domenico Otranto
The immature immune system of cats in their paediatric age (i.e., first six months of life) favours the establishment of infectious respiratory tract diseases mainly caused by well recognized viruses and bacteria species. Conversely, lungworm infections are less investigated during respiratory disorders in kittens. In the last decade, Troglostrongylus brevior has been found affecting the respiratory tract of cats, along with the better-known Aelurostrongylus abstrusus. Given the scant data available on the epidemiology of feline troglostrongylosis, faecal samples from 575 domestic animals living in three Italian municipalities (i...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29590206/worldwide-increased-prevalence-of-human-adenovirus-type-3-hadv-3-respiratory-infections-is-well-correlated-with-heterogeneous-hypervariable-regions-hvrs-of-hexon
#10
Ezazul Haque, Urmila Banik, Tahmina Monwar, Leela Anthony, Arun Kumar Adhikary
Human adenovirus type 3 (HAdV-3) respiratory infections occurs worldwide in both children and adults, leading to severe morbidity and mortality, particularly in the paediatric age group and especially in neonates. During HAdV infection, neutralizing antibodies are formed against the epitopes located in the hyper variable regions (HVRs) of the hexon protein. These neutralizing antibodies provide protection against reinfection by viruses of the same type. Therefore it is reasonable to speculate that variations of HAdV-3 in the HVRs could impair the immunity acquired by previous infection with a different strain with variation in its HVRs...
2018: PloS One
https://www.readbyqxmd.com/read/29554296/the-diagnosis-and-management-of-respiratory-tract-fungal-infection-in-cystic-fibrosis-a-uk-survey-of-current-practice
#11
M Boyle, J E Moore, J L Whitehouse, D Bilton, D G Downey
Aspergillus fumigatus is commonly found in the airways of patients with cystic fibrosis (CF), and allergic bronchopulmonary aspergillosis (ABPA) is the most recognized associated clinical condition. However, accurate diagnosis remains challenging, and there is a paucity of clinical trials to guide clinical management of fungal disease. The aim of this survey was to assess the variability in current practice across the UK in diagnosis and management of fungal lung disease in CF patients. A 21 question anonymous online survey was sent to 94 paediatric and adult CF consultants in the UK...
March 15, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29515662/summer-schools-of-adult-and-paediatric-respiratory-medicine-course-report
#12
EDITORIAL
Iana O Andreieva, Olha Konstantynovska, Fabio Midulla, Diana Marangu, Nino Mchedlishvili
Participants in the 2017 ERS summer schools of adult and paediatric respiratory medicine describe their experiences http://ow.ly/i4y930hzLU0.
March 2018: Breathe
https://www.readbyqxmd.com/read/29480461/fitness-to-fly-in-the-paediatric-population-how-to-assess-and-advice
#13
REVIEW
Joël Israëls, Ad F Nagelkerke, Dick G Markhorst, Marc van Heerde
The number of children on commercial aircrafts is rising steeply and poses a need for their treating physicians to be aware of the physiologic effects and risks of air travel. The most important risk factors while flying are a decrease in partial oxygen pressure, expansion of trapped air volume, low cabin humidity, immobility, recirculation of air and limited options for medical emergencies. Because on-board medical emergencies mostly concern exacerbations of chronic disease, the medical history, stability of current disease and previous flight experience should be assessed before flight...
May 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29436403/chronic-interstitial-lung-disease-in-children
#14
REVIEW
Matthias Griese
Children's interstitial lung diseases (chILD) are increasingly recognised and contain many lung developmental and genetic disorders not yet identified in adult pneumology. Worldwide, several registers have been established. The Australasian Registry Network for Orphan Lung Disease (ARNOLD) has identified problems in estimating rare disease prevalence; focusing on chILD in immunocompetent patients, a period prevalence of 1.5 cases per million children and a mortality rate of 7% were determined. The chILD-EU register highlighted the workload to be covered per patient included and provided protocols for diagnosis and initial treatment, similar to the United States chILD network...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29391051/short-course-antimicrobial-therapy-for-paediatric-respiratory-infections-safer-study-protocol-for-a-randomized-controlled-trial
#15
Jeffrey Pernica, Stuart Harman, April Kam, Jacob Bailey, Redjana Carciumaru, Sarah Khan, Martha Fulford, Lehana Thabane, Robert Slinger, Cheryl Main, Marek Smieja, Mark Loeb
BACKGROUND: Community-acquired pneumonia (CAP) is commonly diagnosed in children. The Infectious Disease Society of America guidelines recommend 10 days of high-dose amoxicillin for the treatment of non-severe CAP but 5-day "short course" therapy may be just as effective. Randomized trials in adults have already demonstrated non-inferiority of 5-day short-course treatment for adults hospitalized with severe CAP and for adults with mild CAP treated as outpatients. Minimizing exposure to antimicrobials is desirable to avoid harms including diarrhoea, rashes, severe allergic reactions, increased circulating antimicrobial resistance, and microbiome disruption...
February 1, 2018: Trials
https://www.readbyqxmd.com/read/29316914/differential-induction-of-malaria-liver-pathology-in-mice-infected-with-plasmodium-chabaudi-as-or-plasmodium-berghei-nk65
#16
Diletta Scaccabarozzi, Katrien Deroost, Yolanda Corbett, Natacha Lays, Paola Corsetto, Fausta Omodeo Salè, Philippe E Van den Steen, Donatella Taramelli
BACKGROUND: Cerebral malaria and severe anaemia are the most common deadly complications of malaria, and are often associated, both in paediatric and adult patients, with hepatopathy, whose pathogenesis is not well characterized, and sometimes also with acute respiratory distress syndrome (ARDS). Here, two species of murine malaria, the lethal Plasmodium berghei strain NK65 and self-healing Plasmodium chabaudi strain AS which differ in their ability to cause hepatopathy and/or ARDS were used to investigate the lipid alterations, oxidative damage and host immune response during the infection in relation to parasite load and accumulation of parasite products, such as haemozoin...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29233756/paediatric-minimally-invasive-abdominal-and-urological-surgeries-current-trends-and-perioperative-management
#17
Myriam Bellon, Alia Skhiri, Florence Julien-Marsollier, Serge Malbezin, Diallo Thierno, Julie Hilly, Alaa ElGhoneimi, Arnaud Bonnard, Daphné Michelet, Souhayl Dahmani
Minimally invasive surgery during abdominal, thoracic and urological procedures has become the standard management of many surgical interventions in adults. Recent development of smaller devices has allowed the management of many paediatric surgeries using these minimally invasive techniques. However, the lack of knowledge of (a) adequate management of haemodynamic and respiratory alterations occurring during those procedures and (b) postoperative advantages of these techniques over open surgeries, still impairs their development...
December 9, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29216678/-guideline-for-the-diagnosis-and-treatment-of-asthma-guideline-of-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-paediatric-respiratory-society-and-the-austrian-society-of-pneumology
#18
R Buhl, R Bals, X Baur, D Berdel, C-P Criée, M Gappa, A Gillissen, T Greulich, P Haidl, E Hamelmann, P Kardos, K Kenn, L Klimek, S Korn, M Lommatzsch, H Magnussen, T Nicolai, D Nowak, O Pfaar, K F Rabe, J Riedler, T Ritz, K Schultz, A Schuster, T Spindler, C Taube, K Taube, C Vogelmeier, A von Leupold, F Wantke, S Weise, J Wildhaber, H Worth, A Zacharasiewicz
The present guideline is a new version and an update of the guideline for the diagnosis and treatment of asthma, which replaces the previous version for german speaking countries from the year 2006. The wealth of new data on the pathophysiology and the phenotypes of asthma, and the expanded spectrum of diagnostic and therapeutic options necessitated a new version and an update. This guideline presents the current, evidence-based recommendations for the diagnosis and treatment of asthma, for children and adolescents as well as for adults with asthma...
December 2017: Pneumologie
https://www.readbyqxmd.com/read/29202565/the-efficacy-of-topical-hyaluronan-in-rhinosinusitis-a-systematic-review
#19
M Casale, P Vella, A Moffa, V Grimaldi, L Sabatino, V Rinaldi, M A Lopez, P Baptista, F Salvinelli
Rhinosinusitis is one of the most common inflammatory conditions of the nasal cavity and paranasal sinuses and is one of the most common causes of absence from work and for visits to the family doctor. The treatment strategy in both acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) is to reduce the severity of the symptoms, minimize the duration of the disease and prevent complications. Topical therapy has become an important tool in otolaryngologists’ armamentarium for rhinosinusitis treatment. Recently, topical hyaluronic acid (HA), the major component of many extracellular matrices that promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration and angiogenesis, has been proposed for ARS and CRS adjuvant tool...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29201634/innovative-chest-physiotherapy-techniques-the-metaneb-%C3%A2-system-in-the-intubated-child-with-extensive-burns
#20
Alexandra Ferguson, Sarah Wright
Introduction: The Metaneb® is a new generation Intrapulmonary Percussive Ventilation device utilised by the physiotherapist to assist airway clearance by providing calibrated oscillations during inspiration up to 3.8Hz. Predominantly used in the adult chronic respiratory patient, with anecdotal evidence in intubated patients, it was also proven to be safe in a paediatric lung model lab study. This case report outlines the first use of the Metaneb® with an intubated child in Australia...
2017: Respiratory Medicine Case Reports
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