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Limb fractures

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https://www.readbyqxmd.com/read/28916811/an-enu-induced-splice-site-mutation-of-mouse-col1a1-causing-recessive-osteogenesis-imperfecta-and-revealing-a-novel-splicing-rescue
#1
Koichi Tabeta, Xin Du, Kei Arimatsu, Mai Yokoji, Naoki Takahashi, Norio Amizuka, Tomoka Hasegawa, Karine Crozat, Tomoki Maekawa, Sayuri Miyauchi, Yumi Matsuda, Takako Ida, Masaru Kaku, Kasper Hoebe, Kinji Ohno, Hiromasa Yoshie, Kazuhisa Yamazaki, Eva Marie Y Moresco, Bruce Beutler
GU-AG consensus sequences are used for intron recognition in the majority of cases of pre-mRNA splicing in eukaryotes. Mutations at splice junctions often cause exon skipping, short deletions, or insertions in the mature mRNA, underlying one common molecular mechanism of genetic diseases. Using N-ethyl-N-nitrosourea, a novel recessive mutation named seal was produced, associated with fragile bones and susceptibility to fractures (spine and limbs). A single nucleotide transversion (T → A) at the second position of intron 36 of the Col1a1 gene, encoding the type I collagen, α1 chain, was responsible for the phenotype...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28913640/case-report-of-kummell-s-disease-with-delayed-onset-myelopathy-and-the-literature-review
#2
REVIEW
Salvatore D'Oria, Carlo Delvecchio, Mariagrazia Dibenedetto, Francesco Zizza, Carlo Somma
INTRODUCTION: Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterised by the gradual development in time of a vertebral body collapse following a trivial spinal trauma, involving a worsening back pain associated with a progressive kyphosis. PURPOSES: The aim of this article is to carry out an international literature review regarding Kummell's disease, addressing its physiopathology, histopathology, clinical presentation, radiological characteristics and treatment modalities; at the same time, the literature is updated through the description of a new and interesting case, symbol of the pathology long-term potential complications, if not diagnosed and therefore not suitably treated...
September 14, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28912392/-refracture-prevention-and-rehabilitation
#3
Hiroaki Fujita
Osteoporosis Liaison Service(OLS)is not only the fracture prevention of the onset, and the refracture prevention holds important positioning. For OLS activity in the hospitals of the fracture risk by FRAX grasp it, and it is important to evaluate the fall risk. What an interval, a motor function including the lower limbs muscular strength evaluate in a fall risk evaluation and TUG and walking speed temporarily for a fall risk evaluation for, the eye opening single leg right time to leave is desirable. It is a problem that an evaluation and treatment for osteoporosis are insufficient by recent DPC induction...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28910377/parametric-analysis-of-occupant-ankle-and-tibia-injuries-in-frontal-impact
#4
Fuhao Mo, Xiaoqing Jiang, Shuyong Duan, Zhi Xiao, Sen Xiao, Wei Shi
OBJECTIVE: Non-fatal tibia and ankle injuries without proper protection from the restraint system has gotten wide attention from researchers. This study aimed to investigate occupant tibia and ankle injuries under realistic frontal impact environment that is rarely considered in previous experimental and simulant studies. METHODS: An integrated occupant-vehicle model was established by coupling an isolated car cab model and a hybrid occupant model with a biofidelic pelvis-lower limb model, while its loading conditions were extracted from the realistic full-frontal impact test...
2017: PloS One
https://www.readbyqxmd.com/read/28906308/is-contralateral-templating-reliable-for-establishing-rotational-alignment-during-intramedullary-stabilization-of-femoral-shaft-fractures-a-study-of-individual-bilateral-differences-in-femoral-version
#5
William P Croom, Daniel J Lorenzana, Richard L Auran, Matthew J Cavallero, Nathanael Heckmann, Jackson Lee, Eric A White
OBJECTIVES: To determine native individual bilateral differences in femoral version in a diverse population. METHODS: Computed tomography scans with complete imaging of uninjured bilateral femora were used to determine femoral version and individual bilateral differences in version. Age, sex, and ethnicity of each subject were also collected. Femoral version and individual bilateral differences in version were correlated with demographic variables using univariate and multivariate regression models...
September 11, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28904732/-type-iii-monteggia-lesion-a-rare-association-about-a-case
#6
Mohamed Amine Oukhouya, Hind Abou El Jaoud, Saad Andaloussi, Hicham Abdellaoui, Karima Atarraf, Lamia Chater, My Abderrahman Afifi
Type III Monteggia lesion is very rare, usually occurring within a context of violent trauma and often going unnoticed. We report the case of a 11-year old boy presenting to the Emergency Department with blunt trauma of the upper limb. The radiological evaluation showed olecranon fracture and radial epiphyseal separation associated with dislocation of the radial head. The patient underwent orthopedic treatment with good outcome after a mean follow-up of 3 months.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904628/tibial-derotational-osteotomies-in-two-neuromuscular-populations-comparing-cerebral-palsy-with-myelomeningocele
#7
R M Thompson, S Ihnow, L Dias, V Swaroop
PURPOSE: To review the outcomes of tibial derotational osteotomies (TDOs) as a function of complication and revision surgery rates comparing a cohort of children with myelodysplasia to a cohort with cerebral palsy (CP). METHODS: A chart review was completed on TDOs performed in a tertiary referral centre on patients with myelodysplasia or CP between 1985 and 2013 in patients aged > 5 years with > 2 years follow-up. Charts were reviewed for demographics, direction/degree of derotation, complications and need for re-derotation...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28899557/can-the-recovery-of-lower-limb-fractures-be-achieved-by-use-of-3d-printing-mirror-model
#8
Wenxi Zhang, Yueping Ji, Xinming Wang, Jie Liu, Dong Li
INTRODUCTION: The mirror imaging 3D printing model can be used a as a reference for anatomical reduction in unilateral lower limb fractures. However, the premise of using mirror technology is that the bilateral lower limb bones are similar enough. Because one side had a fracture, it was impossible to compare this directly to the other side. Usually, surgeons think that the bilateral bones are symmetrical and use mirror technology without judging their symmetry. METHODS: In patients with a unilateral lower limb bone fracture, we measured the long axis and short axis of the three selected transverse sections of the bilateral long bone for comparison to judge the symmetry of the bilateral long bones on CT images...
September 6, 2017: Injury
https://www.readbyqxmd.com/read/28895442/an-alternate-technique-of-applying-lag-screw-for-fixation-of-distal-fibula-fracture-posterior-to-anterior-interfragmentary-compression-screw
#9
Suganth Jayaraman Vijimohan, Syed Haque, David Ellis
Ankle fractures are one of the most common lower limb fractures, representing a significant portion of the trauma workload. Marked proportion of these is isolated intraarticular lateral malleolus fractures. Anatomical reduction and rigid internal fixation using lag screw (interfragmentary screw) to provide interfragmentary compression has remained the choice of treatment in selected lateral malleolus fractures. Applying interfragmentary compression screw from anterior to the posterior surface of the fibula has been the traditional method of performing this...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28893848/a-review-of-10-years-of-scapula-injuries-sustained-by-uk-military-personnel-on-operations
#10
Darren C Roberts, D M Power, S A Stapley
BACKGROUND: Scapula fractures are relatively uncommon injuries, mostly occurring due to the effects of high-energy trauma. Rates of scapula fractures are unknown in the military setting. The aim of this study is to analyse the incidence, aetiology, associated injuries, treatment and complications of these fractures occurring in deployed military personnel. METHODS: All UK military personnel returning with upper limb injuries from Afghanistan and Iraq were retrospectively reviewed using the Royal Centre for Defence Medicine database and case notes (2004-2014)...
September 11, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28891866/passive-transfer-autoimmunity-in-a-mouse-model-of-complex-regional-pain-syndrome
#11
Tian-Zhi Guo, Xiaoyou Shi, Wen-Wu Li, Tzuping Wei, J David Clark, Wade S Kingery
It has been proposed that Complex Regional Pain Syndrome (CRPS) is a post-traumatic autoimmune disease and we previously observed that B cells are required for the full expression of CRPS-like changes a mouse tibia fracture CRPS model. The current study used the mouse model to evaluate the progression of post-fracture CRPS-like changes in wildtype (WT) and muMT fracture mice lacking B cells and antibodies. The pronociceptive effects of injecting WT fracture mouse serum antibodies into muMT fracture mice were also evaluated...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28890727/popliteal-artery-entrapment-or-chronic-exertional-compartment-syndrome
#12
Christopher Gaunder, Brandon McKinney, Jessica Rivera
Diagnosis of lower limb pain in an athlete can be a challenging task due to the variety of potential etiologies and ambiguity of presenting symptoms. Five of the most commonly encountered causes of limb pain in athletes are chronic exertional compartment syndrome (CECS), medial tibial stress syndrome (MTSS), tibial stress fractures, soleal sling syndrome, and popliteal artery entrapment syndrome (PAES). Of these, the least frequent but potentially most serious of the pathologies is PAES. With an incidence of less than 1% seen in living subject studies, the condition is rare...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28885353/association-of-congenital-anomalies-with-fracture-of-spine-trunk-and-upper-and-lower-limbs-among-young-people-a-population-based-matched-cohort-study-in-taiwan
#13
Chia-Man Ma, Lih-Hwa Lin, Hsing-Yi Chang, Pei-Chi Chou, Po-Chi Liao, Huey-Yi Chen, Kee-Ming Man, Jen-Huai Chiang, Yin-Jen Chang, Ming-Yen Tsai, Wen-Chi Chen, Yung-Hsiang Chen
According to the Traditional Chinese Medicine (TCM) theory, congenital anomalies are caused by kidney malfunctions, which decreased the bone quality, and may eventually result in bone fractures. This retrospective cohort study investigated the relationship between congenital anomalies and fracture of spine, trunk, and upper and lower limbs in young people. We utilized data from the National Health Insurance Research Database of Taiwan. This study included patients with congenital anomalies (International Classification of Diseases/ICD-9 code: 740-759) and a comparison group of patients without congenital anomalies...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28884841/sclerostin-antibody-enhances-bone-formation-in-a-rat-model-of-distraction-osteogenesis
#14
Michelle M McDonald, Alyson Morse, Oliver Birke, Nicole Yc Yu, Kathy Mikulec, Lauren Peacock, Aaron Schindeler, Min Liu, Hua Zhu Ke, David G Little
Neutralizing monoclonal sclerostin antibodies are effective in promoting bone formation at a systemic level and in orthopedic scenarios including closed fracture repair. In this study we examined the effects of sclerostin antibody (Scl-Ab) treatment on regenerate volume, density and strength in a rat model of distraction osteogenesis. Surgical osteotomy was performed on 179 Sprague Dawley rats. After 1 week, rats underwent distraction for 2 weeks, followed by 6 weeks for consolidation. Two treatment groups received biweekly subcutaneous Scl-AbIII (a rodent form of Scl-Ab; 25 mg/kg), either from the start of distraction onwards or restricted to the consolidation phase...
September 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28880998/impaired-bone-and-muscle-development-in-young-people-treated-with-antiepileptic-drugs
#15
Peter J Simm, Sebastian Seah, Alex Gorelik, Lauren Gilbert, Jenning Nuguid, George A Werther, Mark T Mackay, Jeremy L Freeman, Sandra J Petty, John D Wark
OBJECTIVE: Antiepileptic drugs (AEDs) are associated with reduced bone density, balance impairment, and increased fracture risk in adults. However, pediatric data are limited. Therefore, we aimed to examine bone, muscle, and balance outcomes in young patients taking AEDs. METHODS: We undertook a case-control study utilizing an AED exposure-discordant matched-pair approach. Subjects were aged 5-18 years with at least 12 months of AED exposure. Pairs were twins, nontwin siblings and first cousins, sex- and age-matched (to within 2 years), allowing for greater power than with unrelated control subjects...
September 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/28876146/effects-of-concomitant-mild-traumatic-brain-injury-on-resuming-work-after-suffering-from-an-isolated-limb-fracture-a-cohort-study
#16
Marianne Jodoin, Dominique M Rouleau, Camille Larson-Dupuis, Benoit Benoit, Stéphane Leduc, G-Yves Laflamme, Nadia Gosselin, Meriem Sabir, Louis De Beaumont
BACKGROUND: The objective is to explore the effects of concomitant mild traumatic brain injury (mTBI) on return to work (RTW), among patients suffering from an isolated limb fracture. This follow-up study included a total of 170 working age subjects with an isolated limb fracture, and was conducted in a phone interview approximately 1-year post trauma. 41 had experienced an mTBI and 129 did not. METHODS: Data were obtained through a phone interview conducted on average 20...
September 6, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28875882/osteosarcoma-patient-outcomes-at-a-south-african-tertiary-hospital
#17
L Lisenda, Z A Linda, F P J Snyman, R D Kyte, M Lukhele
BACKGROUND: Osteosarcoma is the most common primary malignant bone tumour. There is a high incidence of late presentation in the developing world, posing additional challenges in the treatment of this aggressive disease. OBJECTIVE: To evaluate clinical outcomes of patients with osteosarcoma at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), a tertiary hospital in South Africa, and compare these with similar studies in the developing world. METHODS: This was a retrospective study of 61 patients treated at CMJAH between 2007 and 2011, with a minimum follow-up of 1...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28875130/ipsilateral-femur-and-tibia-fractures-in-pediatric-patients-a-systematic-review
#18
Jason B Anari, Alexander L Neuwirth, B David Horn, Keith D Baldwin
AIM: To better understand how pediatric floating knee injuries are managed after the wide spread use of new orthopaedic technology. METHODS: We searched EMBASE, COCHRANE and MEDLINE computerized literature databases from the earliest date available in the databases to February 2017 using the following search term including variants and pleural counterparts: Pediatric floating knee. All studies were thoroughly reviewed by multiple authors. Reference lists from all articles were scrutinized to identify any additional studies of interest...
August 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28872531/flexion-type-supracondylar-humeral-fractures-ulnar-nerve-injury-increases-risk-of-open-reduction
#19
Kelly Flynn, Apurva S Shah, Christopher M Brusalis, Kelly Leddy, John M Flynn
BACKGROUND: The vast majority of displaced pediatric supracondylar humeral fractures can be treated successfully with closed reduction and percutaneous pinning. The need for open reduction is difficult to determine a priori and is typically due to the failure of closed reduction attempts or persistent limb ischemia. The aims of this study were to determine the prevalence of flexion-type supracondylar humeral fractures, the rate of open reduction for flexion-type fractures, and the predictive impact of ulnar nerve injury on the need for open reduction for flexion-type supracondylar humeral fractures...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28872035/prevalence-and-severity-of-peripheral-arterial-disease-among-patient-with-heel-pressure-ulcer-a-retrospective-study-of-42-patients
#20
Guillaume Tisserand, Nora Zenati, Christophe Seinturier, Sophie Blaise, Gilles Pernod
Heel pressure ulcer is a major complication in elderly hospitalized patients. The association with peripheral arterial disease (PAD) which is also a frequent disease in this population is poorly known. The aim of this study was to assess the prevalence of PAD and critical limb ischemia (CLI) in patients with heel pressure ulcer. Patients referred to the vascular medicine department for heel pressure ulcer from October 2014 to June 2015 were included in the study. The assessment of peripheral arterial disease was made with the results of ankle brachial index and/or doppler ultra sound of lower limb arteries...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
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