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leukemia and insulin

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https://www.readbyqxmd.com/read/27875952/in-vitro-sensitivity-profiling-of-neuroblastoma-cells-against-a-comprehensive-small-molecule-kinase-inhibitor-library-to-identify-agents-for-future-therapeutic-studies
#1
Anjali Singh, Vanessa Meier-Stephenson, Aarthi Jayanthan, Aru Narendran
Solid tumors represent one of the most widespread causes of death in children across the world. Neuroblastoma (NB) constitutes about 8% of all childhood tumors, yet accounts for more than 15% of death, with an unacceptable overall survival rate. Despite the current multimodal therapeutic approaches involving surgery, radiation, chemotherapy with myeloablative therapy and hematopoietic stem cell rescue, there is growing realization of the limitations of conventional agents to improve the outcome in high risk metastatic disease...
November 22, 2016: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/27859423/from-obesity-to-cancer-a-review-on-proposed-mechanisms
#2
REVIEW
Zoya Tahergorabi, Majid Khazaei, Mitra Moodi, Elham Chamani
Nowadays, obesity is considered as a serious and growing global health problem. It is documented that the overweight and obesity are major risk factors for a series of noncommunicable diseases, and in recent years, the obesity-cancer link has received much attention. Numerous epidemiological studies have shown that obesity is associated with increased risk of several cancer types, including colon, breast, endometrium, liver, kidney, esophagus, gastric, pancreatic, gallbladder, and leukemia, and can also lead to poorer treatment...
November 9, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27784349/-expression-and-significance-of-insulin-like-growth-factor-binding-protein-3-in-patients-with-acute-myeloid-leukemia
#3
Hong-Zhi Sun, Fan-Jie Meng, Heng-Yue Guo
OBJECTIVE: To explore the gene expression of insulin-like growth factor binding protein 3 (IGFBP3) in bone marrow mononuclear cells and the expression of IGFBP3 in peripheral blood as well their significance. METHODS: A total of 178 patients with acute myeloid leukemia (AML) from March 2014 to March 2016 were divided into de novo AML, CR, and relapse groups according to their condition; Patients with non-hematologic malignancies and normal bone marrow in the same period were selected as control group...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27661006/type-i-insulin-like-growth-factor-receptor-signaling-in-hematological-malignancies
#4
Deeksha Vishwamitra, Suraj Konnath George, Ping Shi, Ahmed O Kaseb, Hesham M Amin
The insulin-like growth factor (IGF) signaling system plays key roles in the establishment and progression of different types of cancer. In agreement with this idea, substantial evidence has shown that the type I IGF receptor (IGF-IR) and its primary ligand IGF-I are important for maintaining the survival of malignant cells of hematopoietic origin. In this review, we discuss current understanding of the role of IGF-IR signaling in cancer with a focus on the hematological neoplasms. We also address the emergence of IGF-IR as a potential therapeutic target for the treatment of different types of cancer including plasma cell myeloma, leukemia, and lymphoma...
September 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27579164/effects-of-myokines-on-bone
#5
REVIEW
Hiroshi Kaji
The links between muscle and bone have been recently examined because of the increasing number of patients with osteoporosis and sarcopenia. Myokines are skeletal muscle-derived humoral cytokines and growth factors, which exert physiological and pathological functions in various distant organs, including the regulation of glucose, energy and bone metabolism. Myostatin is a crucial myokine, the expression of which is mainly limited to muscle tissues. The inhibition of myostatin signaling increases bone remodeling, bone mass and muscle mass, and it may provide a target for the treatment of both sarcopenia and osteoporosis...
2016: BoneKEy Reports
https://www.readbyqxmd.com/read/27574398/dexamethasone-c21-phosphoramide-anti-egfr-molecular-design-synthetic-organic-chemistry-reactions-and-antineoplastic-cytotoxic-potency-against-pulmonary-adenocarcinoma-a549
#6
Cody P Coyne, Lakshmi Narayanan
PURPOSE: Corticosteroids are effective in the management of a variety of disease states, such as several forms of neoplasia (leukemia and lymphoma), autoimmune conditions, and severe inflammatory responses. Molecular strategies that selectively "target" delivery of corticosteroids minimize or prevents large amounts of the pharmaceutical moiety from passively diffusing into normal healthy cell populations residing within tissues and organ systems. MATERIALS AND METHODS: The covalent immunopharmaceutical, dexamethasone-(C21-phosphoramide)-[anti-EGFR] was synthesized by reacting dexamethasone-21-monophosphate with a carbodiimide reagent to form a dexamethasone phosphate carbodiimide ester that was subsequently reacted with imidazole to create an amine-reactive dexamethasone-(C21-phosphorylimidazolide) intermediate...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27541072/adverse-effects-of-imatinib-in-children-with-chronic-myelogenous-leukemia
#7
Worawut Choeyprasert, Thitinun Yansomdet, Rungrote Natesirinilkul, Karn Wejaphikul, Pimlak Charoenkwan
BACKGROUND: Imatinib mesylate (IM) is a selective tyrosine kinase inhibitor and is approved for indefinite treatment of pediatric chronic myelogenous leukemia (CML). Potential side-effects regarding growth failure and bone metabolism have been reported but data are still scarce in pediatric CML. METHODS: Six chronic-phase CML children on IM treatment with a median age of 9.87 years (range, 5.33-12.67 years) were enrolled in the study. Growth, bone mineral density (BMD), bone parameters, 25(OH)-vitamin D3 (25-OHD3) and blood tests including parathyroid hormone, insulin-like growth factor-1 (IGF-1), IGF binding protein 3, thyroid function test and sex hormones were assessed...
August 19, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27532210/igf1r-derived-pi3k-akt-signaling-maintains-growth-in-a-subset-of-human-t-cell-acute-lymphoblastic-leukemias
#8
Samuel Gusscott, Catherine E Jenkins, Sonya H Lam, Vincenzo Giambra, Michael Pollak, Andrew P Weng
Insulin-like growth factor 1 receptor (IGF1R) is a prevalent signaling pathway in human cancer that supports cell growth/survival and thus contributes to aggressive biological behavior. Much work has gone into development of IGF1R inhibitors; however, candidate agents including small molecule tyrosine kinase inhibitors and blocking antibodies have yet to fulfill their promise clinically. Understanding cellular features that define sensitivity versus resistance are important for effective patient selection and anticipation of outgrowth of a resistant clone...
2016: PloS One
https://www.readbyqxmd.com/read/27468475/-inhibitory-effect-of-high-concentration-insulin-on-the-proliferation-of-human-leukemia-cell-strain-k562
#9
Wei-huang Zhuang, Mao-juan Huang, Jing-xin Pan
OBJECTIVE: To study the impact of high concentration insulin on the proliferation and apoptosis of K562 cell strain. METHODS: K562 cells were treated with different concentrations of insulin. The proliferation activity was tested by CCK-8 assay, cytometry, and trypan blue exclusion. The alterations in glucose concentration of the culture media were monitored while the apoptosis of K562 cells was detected by flow cytometry. The effects of high concentration insulin on the proliferation of K562 cells were inhibited by varying concentrations of insulin-like growth factor-1 (IGF-1) and Suramin...
May 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/27451978/asparaginase-associated-pancreatitis-a-study-on-pheno-and-genotype-in-the-nopho-all2008-protocol
#10
B O Wolthers, T L Frandsen, J Abrahamsson, B K Albertsen, L R Helt, M Heyman, Óg Jónsson, L-T Kõrgvee, B Lund, R A Raja, K K Rasmussen, M Taskinen, M R Tulstrup, G E Vaitkevičienė, R Yadav, R Gupta, K Schmiegelow
Asparaginase-associated pancreatitis (AAP) occurs during acute lymphoblastic leukemia treatment. Among 1285 children (1.0-17.9 years) diagnosed 7/2008-12/2014 and treated according to the Nordic/Baltic ALL2008 protocol, 86 (cumulative incidence=6.8%) developed AAP. Seventy-three cases were severe (diagnostic AAP criteria persisting >72 h) and 13 mild. Cases were older than controls (median: 6.5 vs 4.5 years; P=0.001). Pseudocysts developed in 28%. Of 20 re-exposed to ASP, nine (45%) developed a second AAP...
July 25, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27430724/influence-of-cartilage-interstitial-fluid-on-the-mrna-levels-of-matrix-proteins-cytokines-metalloproteases-and-their-inhibitors-in-synovial-membrane
#11
Anna Hyc, Stanislaw Moskalewski, Anna Osiecka-Iwan
Articular cartilage and the synovial membrane both ensure the smooth action of synovial joints; however, the influence of chondrocytes on synovial metabolism remains unclear. The secretory activity of chondrocytes is usually studied in cell cultures and may differ from that in intact cartilage. According to McCutchen's theory of 'weeping' joint lubrication, loading of the articular cartilage during motion squeezes the fluid with lubricating properties from the cartilage. The purpose of the study was to obtain cartilage interstitial fluid (CIF) from intact cartilage and to evaluate its influence on gene expression in the synovial membrane cells...
September 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27423118/transcriptomic-responses-of-marine-medaka-s-ovary-to-hypoxia
#12
Keng Po Lai, Jing Woei Li, Anna Chung Kwan Tse, Angela Cheung, Simon Wang, Ting Fung Chan, Richard Yuen Chong Kong, Rudolf Shiu Sun Wu
Hypoxia, an endocrine disruptor, is pressing global problem affecting marine organisms in over 400 "Dead Zones" worldwide. There is growing evident demonstrated the disruptive effect of hypoxia on reproductive systems of marine fish through the impairments of steroidogenic gene expression, leading to the alteration of sex hormone production in gonads. But the detailed molecular mechanism underlying the responses of female reproductive systems to hypoxic stress remains largely unknown. In the present report, we used marine medaka Oryzias melastigma as a model, together with high-throughput transcriptome sequencing and bioinformatics analysis, aiming to determine the changes in transcriptional signature in the ovary of marine fish under hypoxic stress...
August 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27405060/hepatic-b-cell-leukemia-3-promotes-hepatic-steatosis-and-inflammation-through-insulin-sensitive-metabolic-transcription-factors
#13
Nadine Gehrke, Marcus A Wörns, Yvonne Huber, Moritz Hess, Beate K Straub, Nadine Hövelmeyer, Ari Waisman, Yong Ook Kim, Detlef Schuppan, Peter R Galle, Jörn M Schattenberg
BACKGROUND & AIMS: The pathomechanisms underlying non-alcoholic fatty liver disease (NAFLD) and the involved molecular regulators are incompletely explored. The nuclear factor-kappa B (NF-κB)-cofactor gene B cell leukemia-3 (Bcl-3) plays a critical role in altering the transcriptional capacity of NF-κB - a key inducer of inflammation - but also of genes involved in cellular energy metabolism. METHODS: To define the role of Bcl-3 in non-alcoholic steatohepatitis (NASH), we developed a novel transgenic mouse model with hepatocyte-specific overexpression of Bcl-3 (Bcl-3(Hep)) and employed a high-fat, high-carbohydrate dietary feeding model...
December 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27362350/acute-activation-of-metabolic-syndrome-components-in-pediatric-acute-lymphoblastic-leukemia-patients-treated-with-dexamethasone
#14
Lidewij T Warris, Erica L T van den Akker, Marc B Bierings, Cor van den Bos, Christian M Zwaan, Sebastiaan D T Sassen, Wim J E Tissing, Margreet A Veening, Rob Pieters, Marry M van den Heuvel-Eibrink
Although dexamethasone is highly effective in the treatment of pediatric acute lymphoblastic leukemia (ALL), it can cause serious metabolic side effects. Because studies regarding the effects of dexamethasone are limited by their small scale, we prospectively studied the direct effects of treating pediatric ALL with dexamethasone administration with respect to activation of components of metabolic syndrome (MetS); in addition, we investigated whether these side effects were correlated with the level of dexamethasone...
2016: PloS One
https://www.readbyqxmd.com/read/27327565/the-influence-of-antineoplastic-treatment-on-the-weight-of-survivors-of-childhood-cancer
#15
Julia Ferrari Carneiro Teixeira, Priscila Dos Santos Maia-Lemos, Mônica Dos Santos Cypriano, Luciana Pellegrini Pisani
PURPOSE: Obesity is a late effect in survivors of childhood cancer and correlates with chronic complications. Survivors of leukemia, brain tumors, and hematopoietic stem cell transplantation are more likely to develop obesity resulting from treatment modalities such as radiotherapy and glucocorticoids. This paper analyzes and integrates the current data available to health professionals in order to clarify strategies that can be used to treat and prevent obesity in childhood cancer survivors...
June 18, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27186190/five-years-of-experience-with-rituximab-plus-high-dose-dexamethasone-for-relapsed-refractory-chronic-lymphocytic-leukemia
#16
Martin Šimkovič, Monika Motyčková, David Belada, Pavel Vodárek, Rahul Kapoor, Hamna Jaffar, Filip Vrbacký, Pavel Žák, Lukáš Smolej
INTRODUCTION: High-dose methylprednisolone (HDMP) in combination with rituximab is active in the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL), but serious infections are frequent. Recently published data suggested that high-dose dexamethasone might be equally effective as HDMP despite a lower cumulative dose. MATERIAL AND METHODS: We performed retrospective analysis of 60 patients with relapsed/refractory CLL (median age: 66 years; range: 37-86) treated with rituximab plus dexamethasone (R-dex) at a single tertiary center between September 2008 and October 2012...
April 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27149630/insulin-signaling-in-insulin-resistance-states-and-cancer-a-modeling-analysis
#17
Alessandro Bertuzzi, Federica Conte, Geltrude Mingrone, Federico Papa, Serenella Salinari, Carmela Sinisgalli
Insulin resistance is the common denominator of several diseases including type 2 diabetes and cancer, and investigating the mechanisms responsible for insulin signaling impairment is of primary importance. A mathematical model of the insulin signaling network (ISN) is proposed and used to investigate the dose-response curves of components of this network. Experimental data of C2C12 myoblasts with phosphatase and tensin homologue (PTEN) suppressed and data of L6 myotubes with induced insulin resistance have been analyzed by the model...
2016: PloS One
https://www.readbyqxmd.com/read/27144338/oncogenic-function-of-the-homeobox-a13-long-noncoding-rna-hottip-insulin-growth-factor-binding-protein-3-axis-in-human-gastric-cancer
#18
Sophie Sw Wang, Kenly Wuputra, Chung-Jung Liu, Yin-Chu Lin, Yi-Ting Chen, Chee-Yin Chai, Chen-Lung Steve Lin, Kung-Kai Kuo, Ming-Ho Tsai, Shin-Wei Wang, Ker-Kong Chen, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Tadashi Hanafusa, Deng-Chyang Wu, Chang-Shen Lin, Kazunari K Yokoyama
To study the mechanisms of gastric tumorigenesis, we have established CSN cell line from human normal gastric mucosa, and CS12, a tumorigenic and invasive gastric cancer cell line from CSN passages. Many stem cell markers were expressed in both CSN and CS12 cells, but LGR5 and NANOG were expressed only in CS12 cells. Increased expression of homeobox A13 (HoxA13) and its downstream cascades was significant for the tumorigenic activity of CS12 cells, and was associated with recruitment of E2F-1 to HoxA13 promoter accompanied with increased trimethylation of histone H3 lysine 4 (H3K4me3) at the hypomethylated E2F motifs...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27094350/evaluation-of-endocrine-late-complications-in-childhood-acute-lymphoblastic-leukemia-survivors-a-report-of-single-center-experience-and-review-of-the-literature
#19
Cengiz Bayram, Neşe Yaralı, Ali Fettah, Fatma Demirel, Betül Tavil, Abdurrahman Kara, Bahattin Tunç
INTRODUCTION: Improvement in long-term survival in patients with acute childhood lymphoblastic leukemia (ALL) has led to the need for monitorization of treatment related morbidity and mortality. In tne current study, we aimed to evaluate endocrine side effects of treatment in ALL survivors who were in remission for at least two years. METHODS: Sixty patients diagnosed with acute lymphoblastic leukemia, who were in remission for at least two years, were cross-sectionally evaluated for long-term endocrine compliations...
April 18, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27091452/osteopontin-ablation-ameliorates-muscular-dystrophy-by-shifting-macrophages-to-a-pro-regenerative-phenotype
#20
Joana Capote, Irina Kramerova, Leonel Martinez, Sylvia Vetrone, Elisabeth R Barton, H Lee Sweeney, M Carrie Miceli, Melissa J Spencer
In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates disease progression. Osteopontin (OPN) is an immunomodulator highly expressed in dystrophic muscles. Ablation of OPN correlates with reduced fibrosis and improved muscle strength as well as reduced natural killer T (NKT) cell counts. Here, we demonstrate that the improved dystrophic phenotype observed with OPN ablation does not result from reductions in NKT cells...
April 25, 2016: Journal of Cell Biology
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