Seindé Touré, Charlotte Nirma, Michael Falkowski, Isabelle Dusfour, Isabelle Boulogne, Arnaud Jahn-Oyac, Maïra Coke, Didier Azam, Romain Girod, Céline Moriou, Guillaume Odonne, Didier Stien, Emeline Houël, Véronique Eparvier
Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.
February 24, 2017: Journal of Natural Products