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https://www.readbyqxmd.com/read/28927969/comparison-of-metabolic-syndrome-prevalence-in-patients-with-schizophrenia-and-bipolar-i-disorder
#1
Razieh Nayerifard, Majid Akbari Bureng, Alireza Zahiroddin, Massood Namjoo, Sepideh Rajezi
Research has shown that the metabolic syndrome is more prevalent among patients with schizophrenia or bipolar I disorder. Given the scarcity of research on the disorders, this paper aims to compare the prevalence of the syndrome among the two groups of patients. METHODS: A total of 120 individuals participated in this cross sectional study: 60 patients with schizophrenia (26 males and 34 females) and 60 patients with bipolar I disorder (32 males and 28 females). The psychological disorders were diagnosed by some experienced psychiatrists according to the DSM-V...
May 4, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28924869/the-educational-potential-of-youtube
#2
Haley T Godwin, Murtaza Khan, Peter Yellowlees
OBJECTIVE: The objective of this paper was to examine the educational potential and effectiveness of a 3 min video clip of a simulation of schizophrenia published online at YouTube. METHOD: Researchers examined the 267 public comments published on the video-sharing website YouTube over 8 years by viewers of a schizophrenia simulation video titled "virtual hallucinations" made in the Second Life game platform. Comments were independently categorized into six groupings, then cooperatively finalized, and qualitatively analyzed...
September 18, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#3
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28901217/ethical-and-methodological-issues-in-qualitative-studies-involving-people-with-severe-and-persistent-mental-illness-such-as-schizophrenia-and-other-psychotic-conditions-a-critical-review
#4
Ing-Marie Carlsson, Marjut Blomqvist, Henrika Jormfeldt
Undertaking research studies in the field of mental health is essential in mental health nursing. Qualitative research methodologies enable human experiences to become visible and recognize the importance of lived experiences. This paper argues that involving people with schizophrenia in research is critical to promote their health and well-being. The quality of qualitative research needs scrutinizing according to methodological issues such as trustworthiness and ethical standards that are a fundamental part of qualitative research and nursing curricula...
2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28900063/-translational-research-on-neuropsychiatric-disorders-focusing-on-microglia-hypothesis
#5
Takahiro A Kato, Masahiro Ohgidani, Shigenobu Kanba
Microglia-immune cells in the brain-have recently been highlighted to understand the pathophysiology of psychiatric disorders such as schizophrenia, depression, and autism. In this review paper, we introduce the microglia hypothesis for psychiatric disorders. In addition, we introduce our novel translational research approach to psychiatric disorders using microglia-like (iMG) cells directly induced from human blood, these iMG cells can be produced from peripheral monocytes within two weeks using two cytokines: granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34)...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28875719/the-2016-ranzcp-guidelines-for-the-management-of-schizophrenia-and-related-disorders-what-s-next
#6
Assen Jablensky, David J Castle, Frances Dark, Verity Humberstone, Eoin Killackey, Jayashri Kulkarni, Patrick McGorry, Vera A Morgan, Olav Nielssen, Nga Tran, Cherrie Galletly
OBJECTIVES: The recently published RANZCP guidelines for schizophrenia and related disorders reviewed recent scientific evidence, and, where lacking, referred to clinical expertise to supply a template for raising the standard of care. This paper builds on the guidelines and recommends how they might be used to improve outcomes. METHODS: The guidelines call for evidence-based mental health policies, inclusive of mobilising affected families, communities and the public in support of policies that ensure better care and protect the wellbeing of people with severe mental disorders...
September 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28812221/multimodal-neuroimaging-in-schizophrenia-description-and-dissemination
#7
C J Aine, H J Bockholt, J R Bustillo, J M Cañive, A Caprihan, C Gasparovic, F M Hanlon, J M Houck, R E Jung, J Lauriello, J Liu, A R Mayer, N I Perrone-Bizzozero, S Posse, J M Stephen, J A Turner, V P Clark, Vince D Calhoun
In this paper we describe an open-access collection of multimodal neuroimaging data in schizophrenia for release to the community. Data were acquired from approximately 100 patients with schizophrenia and 100 age-matched controls during rest as well as several task activation paradigms targeting a hierarchy of cognitive constructs. Neuroimaging data include structural MRI, functional MRI, diffusion MRI, MR spectroscopic imaging, and magnetoencephalography. For three of the hypothesis-driven projects, task activation paradigms were acquired on subsets of ~200 volunteers which examined a range of sensory and cognitive processes (e...
August 15, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/28799518/a-neurodevelopment-and-neuroplasticity-based-framework-for-early-intervention-in-psychotic-disorders
#8
E Bora
In recent years there has been growing interest in early intervention in psychotic disorders and a number of clinical and research programmes have been developed. The clinical staging model has been an essential part of early intervention as it provides the rationale of existing programmes. In medicine, clinical staging is a valuable approach in disorders where primary pathology is progressive in nature. However, the clinical staging model of psychosis has been proposed without establishing first that schizophrenia is a primarily progressive disorder...
August 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28763183/-the-most-cited-themes-in-the-research-in-the-field-of-mental-health-analyses-of-six-international-nursing-and-medical-journals
#9
Laura Cunico, Susanna Fredo, Massimo Bernini
INTRODUCTION: The review aimed to identify and analyse the future development on the topic by analysing the main themes discussed in number of scientific journal focused on Mental Health both by nurses and physicians.. METHOD: 4 international journals focused on Mental health and psychiatry International Journal of Mental Health Nursing, Archives of Psychiatric Nursing, American Journal of Psychiatry, Australian and New Zeland Journal of Psychiatry as well as two journal focused generically on health, Journal of Advanced Nursing and Lancet were scrutinized...
April 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28756686/beyond-diagnosis-the-core-sets-for-persons-with-schizophrenia-based-on-the-world-health-organization-s-international-classification-of-functioning-disability-and-health
#10
Juana Gómez-Benito, Georgina Guilera, Maite Barrios, Emilio Rojo, Oscar Pino, Arantxa Gorostiaga, Nekane Balluerka, María Dolores Hidalgo, José Luis Padilla, Isabel Benítez, Melissa Selb
PURPOSE: Based on the International Classification of Functioning, Disability and Health (ICF), this paper presents the results of the process to develop the Comprehensive and Brief Core Sets for schizophrenia that allow to comprehensively describe functioning in persons with schizophrenia. METHODS: Twenty health professionals from diverse backgrounds participated in a formal and iterative decision-making process during an international consensus conference to develop these Core Sets...
July 30, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28756108/diagnostic-validity-of-icd-10-acute-and-transient-psychotic-disorders-and-dsm-5-brief-psychotic-disorder
#11
A C Castagnini, P Fusar-Poli
BACKGROUND: Short-lived psychotic disorders are currently classified under "acute and transient psychotic disorders" (ATPDs) in ICD-10, and "brief psychotic disorder" (BPD) in DSM-5. This study's aim is to review the literature and address the validity of ATPDs and BPD. METHOD: Papers published between January 1993 and December 2016 were identified through searches in Web of Science. Reference lists in the located papers provided further sources. RESULTS: A total of 295 articles were found and 100 were included in the review...
June 2, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28748763/induced-pluripotent-stem-cell-technology-a-paradigm-shift-in-medical-science-for-drug-screening-and-disease-modeling
#12
Meera Nair, Sardul Singh Sandhu, Anil Kumar Sharma
BACKGROUND: Induced Pluripotent Stem Cell (IPSC) Technology is the most advanced research as it offers an attractive alternative for establishing patient-specific IPSCs to recapitulate phenotypes of not only monogenic diseases (viz. Thalassaemia, Sickle cell anemia, Haemophilia, Tay-Sachs disease), but also late-onset polygenic diseases (viz. Parkinson's disease, Alzheimer's disease, schizophrenia). Over the hindsight, numerous studies of the past and current scientists have led to the production, maturation and understanding of induced pluripotent stem cell technology and its use in basic and clinical research...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28745389/efficacy-of-cognitive-rehabilitation-of-attention-executive-functions-and-working-memory-in-psychotic-disorders-a-systematic-review
#13
Lucía Rodríguez-Blanco, Genny Lubrini, Carmen Vidal-Mariño, Marcos Ríos-Lago
dies have postulated that it is the basis of the disease as evidenced by its independent and persistent quality and its relation to prognosis. Research on cognitive deficits in psychotic disorders has led to the development of intervention strategies for the cognitive rehabilitation of these patients. Attention, working memory, and executive functions are among the most widely affected functions and are closely related to the functionality of these patients. This work aims to study the effectiveness of cognitive rehabilitation targeting attention, executive functions, and working memory in people diagnosed with a psychotic disorder (mostly schizophrenia)...
July 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28689498/the-slow-death-of-the-concept-of-schizophrenia-and-the-painful-birth-of-the-psychosis-spectrum
#14
S Guloksuz, J van Os
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader multidimensional psychotic syndrome, yet paradoxically has become the dominant prism through which everything 'psychotic' is observed, even affective states with mild psychosis labelled 'ultra-high risk' (for schizophrenia). The inability of psychiatry to frame psychosis as multidimensional syndromal variation of largely unpredictable course and outcome - within and between individuals - hampers research and recovery-oriented practice...
July 10, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28688282/social-cognition-interventions-for-people-with-schizophrenia-a-systematic-review-focussing-on-methodological-quality-and-intervention-modality
#15
REVIEW
Nina Grant, Megan Lawrence, Antonio Preti, Til Wykes, Matteo Cella
BACKGROUND: People with a diagnosis of schizophrenia have significant social and functional difficulties. Social cognition was found to influences these outcomes and in recent years interventions targeting this domain were developed. This paper reviews the existing literature on social cognition interventions for people with a diagnosis of schizophrenia focussing on: i) comparing focussed (i.e. targeting only one social cognitive domain) and global interventions and ii) studies methodological quality...
June 23, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28684386/patient-driven-innovation-for-mobile-mental-health-technology-case-report-of-symptom-tracking-in-schizophrenia
#16
EDITORIAL
John Torous, Spencer Roux
This patient perspective piece presents an important case at the intersection of mobile health technology, mental health, and innovation. The potential of digital technologies to advance mental health is well known, although the challenges are being increasingly recognized. Making mobile health work for mental health will require broad collaborations. We already know that those who experience mental illness are excited by the potential technology, with many actively engaged in research, fundraising, advocacy, and entrepreneurial ventures...
July 6, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28645779/schizophrenia-and-neurogenesis-a-stem-cell-approach
#17
REVIEW
Angela Iannitelli, Adele Quartini, Paola Tirassa, Giuseppe Bersani
Several recent research findings indicate that schizophrenia (SCZ) may begin with an abnormal neuro-genesis from embryonic Neural Stem Cells (NSCs) and that this process may be particularly vulnerable to a number of genetic and/or environmental disturbances of early brain development. Since it is now well known that neurogenesis is not confined to the womb, but is a protracted process continuing in postnatal life well into adolescence and beyond, and since in the majority of subjects diagnosed with SCZ the first psychotic break occurs in late adolescence or early adulthood, the aim of our paper is to summarize the main findings supporting a possible link between changes in developmental postnatal neurogenesis and SCZ, with a specific focus on the critical period of adolescence and associated environmental risk factors...
June 20, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28645536/imaging-genetics-of-schizophrenia-in-the-post-gwas-era
#18
REVIEW
Ayla Arslan
Imaging genetics is a research methodology studying the effect of genetic variation on brain structure, function, behavior, and risk for psychopathology. Since the early 2000s, imaging genetics has been increasingly used in the research of schizophrenia (SZ). SZ is a severe mental disorder with no precise knowledge of its underlying neurobiology, however, new genetic and neurobiological data generate a climate for new avenues. The accumulating data of genome wide association studies (GWAS) continuously decode SZ risk genes...
June 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28612979/research-and-practice-for-ultra-high-risk-for-psychosis-a-national-survey-of-early-intervention-in-psychosis-services-in-england
#19
Helen J Stain, Lauren Mawn, Stephanie Common, Marie Pilton, Andrew Thompson
BACKGROUND: Evidence from meta-analyses of randomized clinical trials show interventions for young people at ultra-high risk (UHR) of developing psychosis are effective both clinically and economically. While research evidence has begun to be integrated into clinical guidelines, there is a lack of research on the implementation of these guidelines. This paper examines service provision for UHR individuals in accordance with current clinical guidelines within the National Health Service (NHS) in England...
June 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28548580/a-review-of-the-impact-of-exclusion-criteria-on-the-generalizability-of-schizophrenia-treatment-research
#20
REVIEW
Keith Humphreys
Treatment research studies employ criteria that determine which patients are eligible to participate and which are not. When such exclusion criteria produce a treatment research sample that is a small and unrepresentative subset of all patients with a particular disease, clinicians may be hesitant to apply the research results in front-line clinical practice. Accordingly, the present paper reviews the English-language literature on exclusion criteria in schizophrenia treatment research and draws initial conclusions about their impact...
December 0: Clinical Schizophrenia & related Psychoses
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