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Cardiometabolic Syndrome

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https://www.readbyqxmd.com/read/28107043/the-impact-of-meal-timing-on-cardiometabolic-syndrome-indicators-in-shift-workers
#1
Hylton E Molzof, Michael D Wirth, James B Burch, Nitin Shivappa, James R Hebert, Russell L Johnson, Karen L Gamble
The aims of this study were to 1) compare the inflammatory potential of night- and day-shift nurses' diets with regard to time of day and work status and 2) explore how the timing of food intake during work and off-work is associated with cardiometabolic syndrome (CMS) risk factors between these two groups. Female nurses (N = 17; 8 day-shift and 9 night-shift) reported food intake over 9 days. On a middle day off of work, metabolic parameters were measured after an overnight fast. Energy/macronutrient intake and inflammatory potential of dietary intake (as assessed via the Dietary Inflammatory Index(TM)) were calculated for nurses' workdays, work nights, off-work days, and off-work nights...
January 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28104968/effects-of-rosuvastatin-alone-or-in-combination-with-omega-3-fatty-acid-on-adiponectin-levels-and-cardiometabolic-profile
#2
Hayder M Al-Kuraishy, Ali I Al-Gareeb
BACKGROUND: Adiponectin is an important adipocyte-related protein that has been postulated to participate in prevention of the development of metabolic syndrome. The relationship between adiponectin serum levels and risk of coronary artery disease (CAD) has been widely investigated and remains controversial. The aim of the present study was to evaluate the effects of rosuvastatin and/or omega-3 fatty acid on adiponectin serum levels in patients with insulin resistance (IR) and CAD. PATIENTS AND METHODS: This study involved 87 patients with CADs and IR of different etiology, the patients were divided into three groups; 24 patients on treatment with rosuvastatin, 22 patients on treatment with omega-3 fatty acid, 23 patients on treatment with omega-3 fatty acid and rosuvastatin, 18 patients were not previously or currently treated with either rosuvastatin or omega-3 fatty acid, those regarded as control patients...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28095509/body-mass-index-at-accession-and-incident-cardiometabolic-risk-factors-in-us-army-soldiers-2001-2011
#3
Adela Hruby, Lakmini Bulathsinhala, Craig J McKinnon, Owen T Hill, Scott J Montain, Andrew J Young, Tracey J Smith
Individuals entering US Army service are generally young and healthy, but many are overweight, which may impact cardiometabolic risk despite physical activity and fitness requirements. This analysis examines the association between Soldiers' BMI at accession and incident cardiometabolic risk factors (CRF) using longitudinal data from 731,014 Soldiers (17.0% female; age: 21.6 [3.9] years; BMI: 24.7 [3.8] kg/m2) who were assessed at Army accession, 2001-2011. CRF were defined as incident diagnoses through 2011, by ICD-9 code, of metabolic syndrome, glucose/insulin disorder, hypertension, dyslipidemia, or overweight/obesity (in those not initially overweight/obese)...
2017: PloS One
https://www.readbyqxmd.com/read/28079773/pregnancies-after-the-diagnosis-of-mild-gestational-diabetes-mellitus-and-risk-of-cardiometabolic-disorders
#4
Michael W Varner, Madeline Murguia Rice, Mark B Landon, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George R Saade, Alan M Peaceman, Sean C Blackwell, J Peter Vandorsten
OBJECTIVE: To assess the association of subsequent pregnancy with subsequent metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective observational follow-up study of women with mild GDM randomized from 2002 to 2007 to usual care or dietary intervention and glucose self-monitoring. Women were evaluated 5-10 years after the parent study. Participants were grouped according to the number of subsequent pregnancies (group A, none [reference]; group B, one; group C, two or greater)...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28076676/use-of-metformin-for-cardiometabolic-risks-in-psychiatric-practice-need-to-know-safety-issues
#5
Chittaranjan Andrade
Metformin, a biguanide drug, is emerging as an important treatment option for the prevention or treatment of weight gain, type 2 diabetes mellitus, and the metabolic syndrome in psychiatric patients, especially those who require or receive antipsychotic drugs. Metformin treatment is commonly associated with gastrointestinal adverse effects; the risk of these is reduced by gradual dose uptitration, administration of the drug with meals, and use of a time-release formulation. Lactic acidosis, a potentially fatal complication of biguanide therapy, is very rare with metformin; the risk can be reduced by avoidance of its prescription in patients with impaired renal function, impaired liver function, cardiac failure, and certain other conditions...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28062508/arterial-calcification-in-diabetes-mellitus-preclinical-models-and-translational-implications
#6
John N Stabley, Dwight A Towler
Diabetes mellitus increasingly afflicts our aging and dysmetabolic population. Type 2 diabetes mellitus and the antecedent metabolic syndrome represent the vast majority of the disease burden-increasingly prevalent in children and older adults. However, type 1 diabetes mellitus is also advancing in preadolescent children. As such, a crushing wave of cardiometabolic disease burden now faces our society. Arteriosclerotic calcification is increased in metabolic syndrome, type 2 diabetes mellitus, and type 1 diabetes mellitus-impairing conduit vessel compliance and function, thereby increasing the risk for dementia, stroke, heart attack, limb ischemia, renal insufficiency, and lower extremity amputation...
December 22, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28028834/the-association-between%C3%A2-undiagnosed-glycemic-abnormalities-and-cardiometabolic-risk-factors-with-periodontitis-results-from-2007-2009-canadian-health-measures-survey
#7
Aleksandra Zuk, Carlos Quiñonez, Michael Lebenbaum, Laura C Rosella
AIM: The aim was to investigate the association between undiagnosed glycemic abnormalities and cardiometabolic risk factors with periodontitis. METHODS: Using Cycle 1 (2007 to 2009) of Canadian Health Measures Survey, survey-sampling weights were applied to a restricted sample of fasting, non-pregnant adults between 19 - 79 years of age without diagnosed or treated type-2 diabetes. We estimated the prevalence of periodontitis, and various cardiometabolic risk factors according to the clinical diagnostic definition for metabolic syndrome (MetS), recognized by the American Heart Association and National Heart, Lung, and Blood Institute...
December 27, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28012695/birth-weight-for-gestational-age-anthropometric-measures-and-cardiovascular-disease-markers-in-children
#8
Stefan Kuhle, Bryan Maguire, Nicole Ata, Natasha MacInnis, Linda Dodds
OBJECTIVE: To examine the association of birth weight for gestational age with anthropometric measures and cardiometabolic markers in a population-based sample of Canadian children. STUDY DESIGN: The study used data from 2016 children aged 6-12 years from the first 2 cycles of the Canadian Health Measures Survey, a population-based survey of Canadian residents. The main exposure was birth weight for gestational age (small [SGA], large [LGA], and appropriate for gestational age [AGA])...
December 21, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/28009891/ultraviolet-radiation-vitamin-d-and-the-development-of-obesity-metabolic-syndrome-and-type-2-diabetes
#9
Shelley Gorman, Robyn M Lucas, Aidan Allen-Hall, Naomi Fleury, Martin Feelisch
Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome...
December 23, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28003008/glucagon-like-peptide-1-glp-1-receptor-agonists-in-the-treatment-of-obese-women-with-polycystic-ovary-syndrome
#10
Themistoklis Tzotzas, Spyridon N Karras, Niki Katsiki
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females and is often associated with a number of cardiometabolic disorders such as central obesity, dyslipidaemia, hypertension, insulin resistance, hyperinsulinaemia, glucose intolerance and type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 (GLP-1), a gut hormone secreted after a meal, enhances glucose-stimulated insulin secretion and additionally suppresses appetite and gastric motility. Most studies found impaired GLP-1 kinetics in obese individuals, whereas small studies in PCOS reported reduced, normal or even elevated GLP-1 levels...
December 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28002034/serum-progranulin-levels-in-type-2-diabetic-patients-with-metabolic-syndrome
#11
Azam Shafaei, Abdoljalal Marjani, Masoud Khoshnia
INTRODUCTION: The role of progranulin in individuals with metabolic syndrome is not exactly clear.We aimed to assess the serum level of progranulin in type 2 diabetic patients with and without metabolic syndrome and compare them with healthy controls. METHODS: The study included 60 patients with type 2 diabetes and 30 healthy individuals as control groups. Biochemical parameters and progranulin levels were determined. RESULTS: Subjects with metabolic syndrome showed significantly higher levels of triglyceride, waist circumference, BMI, systolic and diastolic blood pressure than subjects without metabolic syndrome and the control groups, while HDL-cholesterol level was significantly lower in subjects with metabolic syndrome...
December 1, 2016: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/27993515/cardiometabolic-risk-is-associated-with-the-severity-of-sleep-disordered-breathing-in-children-with-obesity
#12
Laurie Isacco, Johanna Roche, Sylvain Quinart, David Thivel, Valérie Gillet, Véronique Nègre, Fabienne Mougin
BACKGROUND: The alarming progression of pediatric obesity is associated with the development of sleep-disordered breathing (SDB), and both exhibit similar adverse cardiometabolic health outcomes. Physical activity level (PAL) may counteract sleep and metabolic disturbances. The present study investigates i) the association between the metabolic syndrome in childhood obesity and SDB, ii) the impact of SDB severity on cardiometabolic risk scores and PAL in children with obesity. METHODS: Maturation status (Tanner stages), anthropometric (height, weight, body mass index, waist circumference, body adiposity index) and cardiometabolic characteristics (systolic and diastolic blood pressure, lipid and glycemic profiles) were assessed in 83 obese children (mean±SD, age: 10...
December 16, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27992964/pkr-signalling-and-paradigms-of-cardiometabolic-syndrome
#13
REVIEW
Jaspreet Kalra, Arti Dhar
Metabolic syndrome (Met S) is a collection of the most severe cardio-metabolic risk factors that encompasses raised fasting plasma glucose, dyslipidemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its etiology. Recently, double stranded RNA dependent protein kinase has been found to intersect at the crossroad of oxidative stress, inflammation and apoptosis in several metabolic diseases...
December 19, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27990781/sex-differences-endogenous-sex-hormone-hormones-sex-hormone-binding-globulin-shbg-and-exogenous-disruptors-in-diabetes-and-related-metabolic-outcomes
#14
Simin Liu, Qi Sun
In assessing clinical and pathophysiological development of type 2 diabetes (T2D), the critical role of the sex steroids axis is underappreciated particularly concerning the sex specific relations with many relevant cardiometabolic outcomes. In this issue of the Journal, we provide a comprehensive overview of these strong associations of germline variants in the genes governing the sex-steroids pathways, plasma levels of steroid-hormones, and sex hormone-binding globulin (SHBG) with T2D risk that have been observed in many clinical as well as high-quality large prospective cohorts of men and women across ethnic populations...
December 19, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27990033/ptsd-related-cardiovascular-disease-and-accelerated-cellular-aging
#15
Erika J Wolf, Paula P Schnurr
We reviewed the literature from 2010 to 2016 on the relationship between posttraumatic stress disorder (PTSD) and cardiometabolic health conditions, including metabolic syndrome, coronary artery disease, stroke, and myocardial infarction, among others. Collectively, PTSD was associated with increased risk of cardiometabolic health problems, with pre-clinical and clinical studies offering evidence of behavioral (e.g., poor sleep, cigarette use, poor diet and insufficient exercise) and biological (e.g., autonomic reactivity, inflammation) mediators of these associations...
2016: Psychiatric Annals
https://www.readbyqxmd.com/read/27989505/endothelial-mirnas-as-cellular-messengers-in-cardiometabolic-diseases
#16
REVIEW
Makon-Sébastien Njock, Jason E Fish
Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the underlying mechanisms will advance the development of diagnostic and therapeutic approaches. A prominent feature of cardiometabolic diseases is endothelial dysfunction. Endothelial cell (EC) homeostasis and response to pathological stimuli are controlled by gene regulatory networks in which miRNAs play a critical role...
December 15, 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27983705/riboflavin-reduces-pro-inflammatory-activation-of-adipocyte-macrophage-co-culture-potential-application-of-vitamin-b2-enrichment-for-attenuation-of-insulin-resistance-and-metabolic-syndrome-development
#17
Agnieszka Irena Mazur-Bialy, Ewa Pocheć
Due to the progressive increase in the incidence of obese and overweight individuals, cardiometabolic syndrome has become a worldwide pandemic in recent years. Given the immunomodulatory properties of riboflavin, the current study was performed to investigate the potency of riboflavin in reducing obesity-related inflammation, which is the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis. We determined whether pretreatment with a low dose of riboflavin (10.4-1000 nM) affected the pro-inflammatory activity of adipocyte-macrophage co-culture (3T3 L1-RAW 264...
December 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27981514/visceral-adiposity-index-as-an-indicator-of-cardiometabolic-risk-in-patients-treated-for-craniopharyngioma
#18
Francesco Ferraù, Federica Spagnolo, Oana Ruxandra Cotta, Laura Cannavò, Angela Alibrandi, Giuseppina Tiziana Russo, Tommaso Aversa, Francesco Trimarchi, Salvatore Cannavò
PURPOSE: Craniopharyngioma is associated with metabolic alterations leading to increased cardiovascular mortality. Recently, the visceral adiposity index has been proposed as a marker of visceral adipose tissue dysfunction and of the related cardiometabolic risk. The role of the visceral adiposity index has never been explored in craniopharyngioma patients. We assessed the cardiometabolic risk on the basis of the visceral adiposity index in craniopharyngioma patients. METHODS: We evaluated data of 24 patients treated for craniopharyngioma in a single-centre...
December 16, 2016: Endocrine
https://www.readbyqxmd.com/read/27980495/probiotics-and-disease-a-comprehensive-summary-part-1-mental-and-neurological-health
#19
REVIEW
Keren E Dolan, Heather J Finley, Cathleen M Burns, Margaret G Gasta, Crystal M Gossard, Emily C Parker, Jessica M Pizano, Christy B Williamson, Elizabeth A Lipski
This article series provides a literature review of the disease-specific probiotic strains studied in published clinical trials in humans and animals. The goal of the series is to provide clinically useful tools. The table designs allow for quick access to supportive data related to disease states and will be helpful as a guide for both researchers and clinicians. This first article (part 1) focuses on mental health and neurological conditions. Future articles in this series will review conditions related to cardiometabolic and fatigue syndromes; ear, nose, throat, respiratory, and infectious diseases; immune and dermatological conditions; cancer, gastrointestinal and genitourinary; followed by an article focused on food-based probiotic strains and nutritional supplements...
October 2016: Integrative Medicine
https://www.readbyqxmd.com/read/27974060/contribution-of-binge-eating-behaviour-to-cardiometabolic-risk-factors-in-subjects-starting-a-weight-loss-or-maintenance-programme
#20
Alessandro Leone, Giorgio Bedogni, Veronica Ponissi, Alberto Battezzati, Valentina Beggio, Paolo Magni, Massimiliano Ruscica, Simona Bertoli
The contribution of binge eating (BE) behaviour to cardiometabolic risk factors has been scarcely investigated so far. Previous studies have not considered the nutritional status and lifestyle of subjects suffering from BE. The aim of this study was to evaluate the contribution of BE to the metabolic syndrome (MS), its components, high total cholesterol and high LDL in a large sample of subjects, taking into account nutritional status, dietary habits, smoking status and physical activity. For this purpose, 5175 adults seeking a weight loss or maintenance programme were recruited...
December 2016: British Journal of Nutrition
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