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Cardiometabolic Syndrome

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https://www.readbyqxmd.com/read/28935142/association-between-neck-and-wrist-circumferences-and-cardiometabolic-risk-in-children-and-adolescents-the-caspian-v-study
#1
Roya Kelishadi, Motahar Heidari-Beni, Mostafa Qorbani, Nazgol Motamed-Gorji, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Tahereh Aminaee, Ramin Heshmat
OBJECTIVE: The predictive potentials of neck and wrist circumferences for cardiometabolic risks in children and adolescents remain to be determined. The aim of this study was to evaluate the association of neck and wrist circumferences with some cardiometabolic risk factors in children and adolescents. METHODS: This multicenter study was conducted during the 2014 to 2015 school year with 4200 children and adolescents ages 7 to 18 y. The children were selected by multistage cluster sampling from 30 provinces of Iran...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28930524/hypertension-and-cardiometabolic-disease
#2
Ivan Tasic, Dragan Lovic
Hypertension has  a central role in cardiometabolic disease and is usually associated with  metabolic disorders, such as insulin resistance, obesity, and dyslipidemia. Hyperinsulinemia may increase cardiovascular (CV) risk through its promotion of hypertension, which is possibly a result of chronic enhancement of sympathetic nervous system activity, stimulation of the renin-angiotensin-aldosterone system leading to increased renal tubular sodium reabsorption, modulating cation transport, or inducing vascular smooth muscle cell hypertrophy...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28921828/hdl-c-apoa-i-a-multi-vessel-cardiometabolic-risk-marker-in-women-with-t2dm
#3
Michel P Hermans, Paul Valensi, Sylvie A Ahn, Michel F Rousseau
AIMS: Although women have higher HDL-C than men, their HDL particles are also prone to become small, dense and dysfunctional in case of T2DM. To assess the vascular risk related to HDLs of different sizes/densities without direct measurement, we adjusted HDL-C to its main apolipoprotein (apoA-I), as [HDL-C/apoA-I]. This ratio estimates HDLs size and provides indices as to their number, cholesterol load, and density. METHODS: We stratified 280 Caucasian T2DM women according to [HDL-C/apoA-I] quartiles (Q), to determine how it segregates cardiometabolic risk, β-cell function, glycemic control, and vascular complications...
September 15, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28912358/combined-oral-contraceptives-plus-spironolactone-compared-with-metformin-in-women-with-polycystic-ovary-syndrome-a-one-year-randomized-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Macarena Alpañés, Francisco Álvarez-Blasco, Elena Fernández-Durán, Manuel Luque-Ramírez, Héctor F Escobar-Morreale
OBJECTIVE: We aimed to compare a combined oral contraceptive (COC) plus the antiandrogen spironolactone with the insulin sensitizer metformin in women with polycystic ovary syndrome (PCOS). DESIGN: We conducted a randomized, parallel, open-label, clinical trial comparing COC (30 μg of ethinylestradiol and 150 μg of desogestrel) plus spironolactone (100 mg/day) with metformin (850 mg b.i.d.) for one year in women with PCOS (EudraCT2008-004531-38). METHODS: The composite primary outcome included efficacy (amelioration of hirsutism, androgen excess and menstrual dysfunction) and cardiometabolic safety (changes in the frequencies of disorders of glucose tolerance, dyslipidemia and hypertension)...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28911155/differential-associations-of-inflammatory-markers-with-insulin-sensitivity-and-secretion-the-prospective-metsim-study
#5
Maria Fizelova, Raimo Jauhiainen, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Johanna Kuusisto, Markku Laakso, Alena Stancáková
Context: Low-grade inflammation is involved in the development of type 2 diabetes and cardiovascular disease (CVD); however, prospective studies evaluating inflammatory markers as predictors of changes in insulin secretion and insulin sensitivity are lacking. Objective: We investigated the associations of glycoprotein acetyls (GlycA), interleukin-1 receptor antagonist (IL-1RA), and high-sensitivity C-reactive protein (hs-CRP) with insulin secretion, insulin sensitivity, incident type 2 diabetes, hypertension, CVD events, and total mortality in the prospective Metabolic Syndrome in Men (METSIM) study...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28910540/sleep-quality-chronotype-and-metabolic-syndrome-components-in-bipolar-disorders-during-the-remission-period-results-from-the-face-bd-cohort
#6
Ophélia Godin, Chantal Henry, Marion Leboyer, Jean-Michel Azorin, Valerie Aubin, Frank Bellivier, Mircea Polosan, Philippe Courtet, Sebastien Gard, Jean-Pierre Kahn, Josephine Loftus, Christine Passerieux, Dominique Costagliola, Bruno Etain
Data on sleep or circadian abnormalities and metabolic disturbances in euthymic bipolar disorders are scarce and based on small sample sizes. The aim of this study was to explore the associations between sleep disturbances, chronotype and metabolic components in a large sample of euthymic patients with bipolar disorders (BD). From 2009 to 2015, 752 individuals with bipolar disorders from the FACE-BD cohort were included and assessed for sleep quality, chronotype and metabolic components. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) was used to confirm the diagnosis of BD...
September 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28901968/medical-comorbidity-in-polycystic-ovary-syndrome-with-special-focus-on-cardiometabolic-autoimmune-hepatic-and-cancer-diseases-an-updated-review
#7
Dorte Glintborg, Marianne Andersen
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is defined by hyperandrogenism, irregular menses and polycystic ovaries when other causes are excluded. The possible implication of increased morbidity in PCOS for screening and follow-up is uncertain and is reviewed in this article. RECENT FINDINGS: The increased risk of type 2 diabetes and cardiovascular disease in PCOS is closely associated with BMI. Women with PCOS should be screened for the elements of the metabolic syndrome upon diagnosis...
September 8, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28901851/gestational-diabetes-mellitus-post-partum-risk-and-follow-up
#8
Silpa Poola-Kella, Rachel A Steinman, Bayan Mesmar, Rana Malek
BACKGROUND: Women with gestational diabetes mellitus (GDM) are at an increased risk for developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. In this review, we will discuss postpartum cardiovascular and diabetes risk in women with a history of GDM and different ways to improve postpartum screening. METHODS: This review involves a comprehensive literature review on gestational diabetes and post-partum risk for cardiovascular disease and diabetes mellitus as well as post-partum screening methods...
September 11, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28899393/the-mixed-benefit-of-low-lipoprotein-a-in-type-2-diabetes
#9
Michel P Hermans, Sylvie A Ahn, Michel F Rousseau
BACKGROUND: Lipoprotein(a) (Lp(a)), a variant low-density lipoprotein (LDL), is a major genetic risk factor for cardiovascular disease. It is unknown whether an inverse relationship exists between Lp(a) and β-cell function (BCF), as for LDL-cholesterol (LDL-C) lowering by statins. We therefore assessedthe cardiometabolic phenotype of 340 men with type 2 diabetes mellitus (T2DM) in relation to Lp(a), focusing on BCF and hyperbolic product [BxS], which adjusts BCF to insulin sensitivity and secretion...
September 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28882980/the-metabolic-syndrome-and-its-components-in-178-patients-treated-for-craniopharyngioma-after-16-years-of-follow-up
#10
Mark Wijnen, Daniel S Olsson, Marry M van den Heuvel-Eibrink, Casper Hammarstrand, Joseph A M J L Janssen, A J Van der Lely, Gudmundur Johannsson, Sebastian J C M M Neggers
OBJECTIVE: Patients with craniopharyngioma are at increased risk for cardio- and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its components in patients with craniopharyngioma. DESIGN: Cross-sectional study with retrospective data. METHODS: We studied the prevalence of and risk factors for the MetS and its components in 110 Dutch (median age 47 years, range 18-92) and 68 Swedish (median age 50 years, range 20-81) patients with craniopharyngioma with ≥3 years of follow-up (90 females [51%]; 83 patients with childhood-onset craniopharyngioma [47%]; median follow-up after craniopharyngioma diagnosis 16 years [range 3-62])...
September 7, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28878765/dyslipidemic-diet-induced-monocyte-priming-and-dysfunction-in-non-human-primates-is-triggered-by-elevated-plasma-cholesterol-and-accompanied-by-altered-histone-acetylation
#11
John D Short, Sina Tavakoli, Huynh Nga Nguyen, Ana Carrera, Chelbee Farnen, Laura A Cox, Reto Asmis
Monocytes and the recruitment of monocyte-derived macrophages into sites of inflammation play a key role in atherogenesis and other chronic inflammatory diseases linked to cardiometabolic syndrome and obesity. Previous studies from our group have shown that metabolic stress promotes monocyte priming, i.e., enhanced adhesion and accelerated chemotaxis of monocytes in response to chemokines, both in vitro and in dyslipidemic LDLR(-/-) mice. We also showed that metabolic stress-induced monocyte dysfunction is, at least to a large extent caused by the S-glutathionylation, inactivation, and subsequent degradation of mitogen-activated protein kinase phosphatase 1...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28877875/metabolic-syndrome-risks-following-the-great-recession-in-rural-black-young-adults
#12
Gregory E Miller, Edith Chen, Tianyi Yu, Gene H Brody
BACKGROUND: Some of the country's highest rates of morbidity and mortality from cardiovascular disease are found in lower-income black communities in the rural Southeast. Research suggests these disparities originate in the early decades of life, and partly reflect the influence of broader socioeconomic forces acting on behavioral and biological processes that accelerate cardiovascular disease progression. However, this hypothesis has not been tested explicitly. Here, we examine metabolic syndrome (MetS) in rural black young adults as a function of their family's economic conditions before and after the Great Recession...
September 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28860092/high-serum-adipocyte-fatty-acid-binding-protein-level-as-a-potential-biomarker-of-aortic-arterial-stiffness-in-hypertensive-patients-with-metabolic-syndrome
#13
Ming-Chun Chen, Bang-Gee Hsu, Chung-Jen Lee, Chiu-Fen Yang, Ji-Hung Wang
BACKGROUND: The adipocyte-fatty-acid-binding protein (A-FABP) has been implicated in arterial stiffness, metabolic syndrome (MetS), and cardiovascular disease. We aimed to determine the relationship among serum A-FABP concentration, cardiometabolic risk factors, and central arterial stiffness in a hypertensive population. METHODS: Fasting blood samples and baseline characteristics were obtained from 110 hypertensive patients. Serum A-FABP concentrations were determined by enzyme immunoassay kit...
October 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28856601/chromium-supplementation-reduces-resting-heart-rate-in-patients-with-metabolic-syndrome-and-impaired-glucose-tolerance
#14
Barbora Nussbaumerova, Hana Rosolova, Miroslav Krizek, Frantisek Sefrna, Jaroslav Racek, Ludek Müller, Christian Sindberg
Chromium (Cr) is considered as an important mineral, involved in biochemical reactions in human metabolic pathways. Organically bound Cr supplementation has been suggested to improve glycemia especially in patients with type 2 diabetes mellitus, but there are conflicting reports on efficacy. Effect of Cr is not clear in prediabetes status. Seventy patients with metabolic syndrome and impaired glucose tolerance (IGT), who are observed and treated in the Center of Preventive Cardiology of the University Hospital in Pilsen, were included in the prospective, randomized, double-blind, and placebo-controlled clinical study...
August 30, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28851958/predictive-value-of-serum-gamma-glutamyltranspeptidase-for-future-cardiometabolic-dysregulation-in-adolescents-a-10-year-longitudinal-study
#15
Chien-Ming Lin, Chang-Hsun Hsieh, Chien-Hsing Lee, Dee Pei, Jiunn-Diann Lin, Chung-Ze Wu, Yao-Jen Liang, Yi-Jen Hung, Yen-Lin Chen
Serum gamma-glutamyltransferase (γ-GT) is implicated in the pathogenesis of atherosclerosis and metabolic syndrome (MetS) in adults. The relationships between γ-GT and cardiometabolic dysregulation remains unclear in adolescents. We enrolled 7,072 Taiwanese adolescents and followed them for a median of 6.8 years. The optimal cut-off values (CoVs) of baseline γ-GT to predict future MetS, hypertension (HTN), and type 2 diabetes (T2DM) were determined by receiving operating characteristic (ROC) curve. Using these CoVs, the participants were divided into normal- and high-level groups...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846513/low-volume-high-intensity-interval-training-is-sufficient-to-ameliorate-the-severity-of-metabolic-syndrome
#16
Joyce S Ramos, Lance C Dalleck, Fabio Borrani, Kassia S Beetham, Matthew P Wallen, Alistair R Mallard, Bronwyn Clark, Sjaan Gomersall, Shelley E Keating, Robert G Fassett, Jeff S Coombes
BACKGROUND: High-intensity interval training (HIIT) is superior to moderate-intensity continuous training (MICT) at improving cardiometabolic risk. However, the optimal volume of HIIT to reduce the severity of the metabolic syndrome (MetS) has yet to be investigated. The aim of this study was to examine the impact of different volumes of HIIT and MICT on MetS severity (MetS z-score). METHODS: This was a substudy of the "Exercise in prevention of Metabolic Syndrome" (EX-MET) multicenter trial, reporting data collected at the Brisbane site...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28834907/prevalence-of-type-2-diabetes-and-impaired-fasting-glucose-in-patients-affected-by-rheumatoid-arthritis-results-from-a-cross-sectional-study
#17
Piero Ruscitti, Francesco Ursini, Paola Cipriani, Francesco Ciccia, Vasiliki Liakouli, Francesco Carubbi, Giuliana Guggino, Onorina Berardicurti, Rosadaniela Grembiale, Giovanni Triolo, Giovambattista De Sarro, Roberto Giacomelli
Although the better management of rheumatoid arthritis (RA) has significantly improved the long-term outcome of affected patients, a significant proportion of these may develop associated comorbidities including cardiometabolic complications. However, it must be pointed out that a comprehensive cardiometabolic evaluation is still poorly integrated into the management of RA patients, due to a limited awareness of the problem, a lack of appropriate clinical studies, and optimal strategies for cardiovascular (CV) risk reduction in RA...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28828296/cardiometabolic-risk-factors-in-children-with-celiac-disease-on-a-gluten-free-diet
#18
REVIEW
Caterina Anania, Lucia Pacifico, Francesca Olivero, Francesco Massimo Perla, Claudio Chiesa
Celiac disease (CD) is an immune-mediated systemic condition evoked by gluten and related prolamines in genetically predisposed subjects. It is characterised by a variable combination of gluten-dependent clinical symptoms, CD-specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. The only therapy of CD consists of a life-long gluten free diet (GFD). Strict GFD adherence results in full clinical, serological and histological remission, avoiding long-term complications in CD patients. However, this diet is not without problems...
August 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28826615/glycerol-3-phosphate-phosphatase-pgp-role-in-intermediate-metabolism-and-target-for-cardiometabolic-diseases
#19
REVIEW
Elite Possik, S R Murthy Madiraju, Marc Prentki
Metabolic diseases, including obesity, type 2 diabetes, and metabolic syndrome arise because of disturbances in glucose and fat metabolism, which impact associated physiological events such as insulin secretion and action, fat storage and oxidation. Even though, decades of research has contributed to our current understanding of the components involved in glucose and fat metabolism and their regulation, that led to the development of many therapeutics, there are still many unanswered questions. Glycerol-3-phosphate (Gro3P), which is formed during glycolysis, is at the intersection of glucose and fat metabolism, and the availability of this metabolite can regulate energy and intermediary metabolism in mammalian cells...
August 4, 2017: Biochimie
https://www.readbyqxmd.com/read/28822563/effect-of-pericardial-fat-volume-and-density-on-markers-of-insulin-resistance-and-inflammation-in-patients-with-human-immunodeficiency-virus-infection
#20
Chris T Longenecker, Seunghee Margevicius, Yiying Liu, Mark D Schluchter, Chun-Ho Yun, Hiram G Bezerra, Grace A McComsey
Treated human immunodeficiency virus (HIV) infection is characterized by ectopic fat deposition, a persistent inflammatory state, and increased cardiometabolic risk. In this secondary analysis of a placebo controlled trial of rosuvastatin among 147 HIV+ subjects (median age 46; 78% men) on stable antiretroviral therapy, we aimed to evaluate longitudinal associations between computed tomography (CT) measures of pericardial fat (PCF) volume and density, insulin resistance, and inflammation. We measured PCF volume and density (mean attenuation in Hounsfield units) by noncontrast gated CT at baseline and week 96...
July 24, 2017: American Journal of Cardiology
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