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Cardiometabolic Syndrome

Debjani S Goswami, Tanuja P Manohar
INTRODUCTION: Cardiovascular diseases are becoming the major cause of morbidity and mortality in most of the developing countries including India. Cardiometabolic risk factors play a vital role in causation of coronary artery disease. Present study was carried out to investigate the role of various risk factors in the occurrence of coronary artery disease (CAD) in population from Central India. SETTING AND DESIGN: This was a hospital-based age and sex matched case-control study, carried out at Lata Mangeshkar Hospital, Nagpur...
October 2016: Journal of the Association of Physicians of India
Maria Helena Gusmao-Sena, Karine Curvello-Silva, Jairza Maria Barreto-Medeiros, Carla Hilário Da-Cunha-Daltro
INTRODUCTION: The main changes in the body composition refer to the increase of adipose tissue and/or the decrease of muscular mass, and these changes have effect in many clinical outcomes. Sarcopenic obesity (SO) consists of the presence of excessive adipose tissue and deficit of muscular mass simultaneously. People with SO may have synergistic effect due to obesity and sarcopenia, with increases cardiovascular risk more than obesity itself. OBJECTIVE: To describe the findings in the literature about the association between SO and risk factors and/or cardiometabolic disease (CMD) or cardiovascular disease (CVD)...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Ki Chul Sung
Metabolic syndrome (MetS) is a clustering of cardiometabolic risk factors linked to insulin resistance and visceral obesity. Since 1988, when Gerald Reaven first described MetS as "Syndrome X," an abundance of research has been undertaken on its pathophysiology, prognosis, implications, therapeutic strategies, and clinical relationships with other metabolic diseases. Experts have focused on MetS during the last few decades not only because of the increasing importance of obesity in the development of metabolic diseases but also because of the effect of MetS on mortality and the development of cardiovascular diseases...
September 2016: Journal of Hypertension
Riccardo Sarzani
Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are the cardiac natriuretic peptides (NP), true "cardiometabolic" hormones well known for their renal, endocrine and cardiovascular activities leading to reduced sodium reabsorption and arterial blood pressure. These effects are mainly mediated by the second messenger cGMP that also stimulates lipolysis, mitochondriogenesis and a thermogenic program with potency similar to catecholamines. Two distinct NP receptors modulate the final response to cardiac NP: the cGMP-signaling receptor NPRA and the clearance receptor NPRC...
September 2016: Journal of Hypertension
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0162247.].
2016: PloS One
Naval K Vikram, Ahmad Nawid Latifi, Anoop Misra, Kalpana Luthra, Surya Prakash Bhatt, Randeep Guleria, Ravindra M Pandey
OBJECTIVE: The aim of this study was to compare the discriminatory ability of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) in identifying the presence of cardiometabolic risk factors in Asian Indians. METHODS: This cross-sectional study involved 509 subjects (278 males and 231 females) aged 20-60 years from New Delhi, India. Measurements included complete clinical examination, blood pressure, weight, height, WC, BMI, WHR and WHtR, fasting blood glucose, lipid profile, and fasting insulin levels...
October 14, 2016: Metabolic Syndrome and related Disorders
Vojtěch Hainer, Hana Zamrazilová, Irena Aldhoon Hainerová
Associations of both hypothyroidism and subclinical hypothyroidism with metabolic syndrome are well established. Nowadays, more attention has been paid to the role of thyroid hormones and thyrotropin (TSH) within the euthyroid range on the development of cardiometabolic health risks. The paper summarizes current knowledge related to the associations of lower free thyroxine (fT4) level and higher levels of both free triiodothyronine (fT3) and TSH with body adiposity, metabolic syndrome and insulin resistance in euthyroid subjects...
2016: Vnitr̆ní Lékar̆ství
F Borghi, B Sevá-Pessôa, D M Grassi-Kassisse
Cardiometabolic diseases are linked to a cluster of modifiable factors, including risk factors closely related to central adiposity. Chronic renin-angiotensin-aldosterone system (RAAS) activation has far-reaching effects on cardiometabolic risk and is a substantial contributor to this clinical condition. RAAS components are locally expressed in the vessels and adipose tissue. This review appoints RAAS, through the classical and the alternative view, as the main mediator of the cross-talk in cardiometabolic syndrome...
October 12, 2016: Cell and Tissue Research
Mohammad Hossein Panahi, Farzad Hadaegh, Parvin Yavari, Sara Kazempour-Ardebili, Yadollah Mehrabi, Fereidoun Azizi, Davood Khalili
INTRODUCTION: Controversial findings are reported on the risk of cardiovascular disease in chronic kidney disease (CKD). There are some interactions between CKD and other metabolic disorders including metabolic syndrome (MS) and obesity regarding coronary heart disease (CHD) outcomes. MATERIALS AND METHODS: A total of 2823 men and 3684 women aged 30 years and older, without cardiovascular disease, were followed for 10 years. Multivariable adjusted hazard ratio of CHD was estimated for those who developed CKD, MS or both by sex and body mass index levels below and above 27 kg/m2...
September 2016: Iranian Journal of Kidney Diseases
Leila Kheirandish-Gozal, David Gozal
Since the initial report 40 years ago on pediatric obstructive sleep apnea syndrome (OSAS) as a distinct and prevalent clinical entity, substantial advances have occurred in the delineation of diagnostic and treatment approaches. However, despite emerging and compelling evidence that OSAS increases the risk for cognitive, cardiovascular and metabolic end-organ morbidities, routine assessment of such morbidities is seldom conducted in clinical practice. One of the major reasons for such discrepancies resides in the relatively labor-intensive and onerous steps that would be required to detect the presence of any of such morbidities, further adding to the already elevated cost of diagnosing the disorder...
October 6, 2016: Chest
Milena Monfort-Pires, Sandra Roberta G Ferreira
OBJECTIVE: The aim of this study was to investigate the effects of two interventions in breakfast with different fatty acid content on metabolic and inflammatory biomarkers in individuals at different cardiovascular risk levels. METHODS: This crossover clinical trial included 80 overweight participants who were grouped according to the presence of metabolic syndrome (MetS). The participants received two isocaloric breakfast interventions for 4 wk, with a 2-wk washout...
August 9, 2016: Nutrition
Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao, Ming Li
BACKGROUND: Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched factor, we hypothesize that betatrophin might be regulated by vitamin D, and ignorance of vitamin D status may explain the discrepancy in previous human studies. The aims of this study were to assess the association between circulating betatrophin and glucose homeostasis as well as other cardiometabolic variables in a cohort of youths at risk for metabolic syndrome and test the possible influence of vitamin D status on the association...
October 6, 2016: Cardiovascular Diabetology
E A Fletcher, S A McNaughton, K E Lacy, D W Dunstan, V Carson, J Salmon
OBJECTIVE: Evidence suggests that TV viewing is associated with body mass index (BMI) and metabolic syndrome (MetS) in adolescents. However, it is unclear whether dietary intake mediates these relationships. METHODS: A cross-sectional analysis was conducted in adolescents (12-19 years) participating in the 2003-2006 United States National Health and Nutrition Examination Survey. BMI z scores (zBMI) (n = 3,161) and MetS (n = 1,379) were calculated using age- and sex-specific criteria for adolescents...
September 2016: Obesity Science & Practice
Samuel Kingue, Solofonirina Rakotoarimanana, Nirina Rabearivony, Francois Lepira Bompera
AIM: Cardiovascular diseases (CVDs) are a global challenge but the burden in sub-Saharan African (SSA) countries is less well documented than elsewhere. We aimed to describe the key cardiometabolic risk factors in four SSA countries. METHODS: A cross-sectional, multi-national, hospital-based study was carried out among adults (> 35 years) across four SSA countries from 12 December 2011 to 7 February 2013. Risk factors were defined using the World Health Organisation and International Diabetes Federation guidelines...
August 22, 2016: Cardiovascular Journal of Africa
Yue-E Wu, Chong-Lin Zhang, Qing Zhen
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors, including central obesity, insulin resistance, glucose intolerance, dyslipidemia and increased blood pressure. The prevalence of MetS is on the increase worldwide owing to the epidemic of overweight and obesity. The risk of prevalence of MetS greatly increases during adulthood for those children exposed to cardiometabolic risk factors in their early lives. MetS has also been associated with liver fat accumulation in children. Elevated levels of plasma alanine aminotransferase and γ-glutamyl transferase have been associated with liver fat accumulation...
October 2016: Experimental and Therapeutic Medicine
Mohsen Mazidi, Peymane Vadadian, Peyman Rezaie, Mahmoud Reza Azarpazhooh, Habib Esmaeili, Majid Ghayour-Mobarhan, Andre Pascal Kengne, Gordon A Ferns
AIM: We aimed to investigate the relationship between carotid Intima Media Thickness (CIMT) and physical activity levels (PAL), in subjects with and without metabolic syndrome (MetS) and in indidiviuals with and without carotid artery plaque (CAP) defined using high-resolution ultrasound. METHOD: A sample of 506 subjects [215 (42.5%) males], aged 35-64 years was recruited from an urban population in Mashhad, Iran, using a stratified-cluster method as part of the Mashhad Stroke Heart Atherosclerosis Disorder (MASHAD) study cohort...
August 23, 2016: Diabetes & Metabolic Syndrome
Elisa Maseroli, Egidia Fanni, Sarah Cipriani, Irene Scavello, Francesca Pampaloni, Cesare Battaglia, Massimiliano Fambrini, Edoardo Mannucci, Emmanuele A Jannini, Mario Maggi, Linda Vignozzi
INTRODUCTION: The relation between sexual and cardiovascular health in women is not well defined. Clitoral color Doppler ultrasound (CDU) with assessment of the pulsatility index (PI), reflecting resistance to blood flow, has been proposed as an objective measurement of sexual functioning. AIM: To investigate associations between clitoral PI and cardiometabolic risk factors, sexual and intrapsychic parameters, and self-perception of body image. METHODS: Seventy-one adult heterosexual women in a stable relationship attending our clinic for sexual dysfunction were consecutively recruited...
September 27, 2016: Journal of Sexual Medicine
Soledad Pitra, Yumei Feng, Javier E Stern
BACKGROUND: Hypertension and obesity are highly interrelated diseases, being critical components of the metabolic syndrome. Despite the growing prevalence of this syndrome in the world population, efficient therapies are still missing. Thus, identification of novel targets and therapies are warranted. An enhanced activity of the hypothalamic renin-angiotensin system (RAS), including the recently discovered prorenin (PR) and its receptor (PRR), has been implicated as a common mechanism underlying aberrant sympatho-humoral activation that contributes to both metabolic and cardiovascular dysregulation in the metabolic syndrome...
October 2016: Molecular Metabolism
Jane J Lee, Alison Pedley, Udo Hoffmann, Joseph M Massaro, Caroline S Fox
BACKGROUND: Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) are associated with adverse cardiometabolic risk profiles. OBJECTIVES: This study explored the degree to which changes in abdominal fat quantity and quality are associated with changes in cardiovascular disease (CVD) risk factors. METHODS: Study participants (n = 1,106; 44.1% women; mean baseline age 45.1 years) were drawn from the Framingham Heart Study Third Generation cohort who participated in the computed tomography (CT) substudy Exams 1 and 2...
October 4, 2016: Journal of the American College of Cardiology
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