keyword
MENU ▼
Read by QxMD icon Read
search

g6pase

keyword
https://www.readbyqxmd.com/read/29442133/follicle-stimulating-hormone-enhances-hepatic-gluconeogenesis-by-grk2-mediated-ampk-hyperphosphorylation-at-ser485-in-mice
#1
Xiaoyi Qi, Yanjing Guo, Yongfeng Song, Chunxiao Yu, Lifang Zhao, Li Fang, Dehuan Kong, Jiajun Zhao, Ling Gao
AIMS/HYPOTHESIS: Increased serum follicle-stimulating hormone (FSH) is correlated with fasting hyperglycaemia. However, the underlying mechanism remains unclear. Because excessive hepatic gluconeogenesis is a major cause of fasting hyperglycaemia the present study investigated whether FSH increases hepatic gluconeogenesis in mice. METHODS: Ovariectomised mice supplemented with oestradiol (E2) to maintain normal levels of serum E2 (OVX+E2 mice) were injected with low or high doses of FSH...
February 13, 2018: Diabetologia
https://www.readbyqxmd.com/read/29434820/itraconazole-attenuates-hepatic-gluconeogenesis-and-promotes-glucose-uptake-by-regulating-ampk-pathway
#2
Ri-Su Na, Cong Ma, Qiao-Rui Liu, Li-Ming Wu, Xu-Lei Zheng, Zhi-Wen Liu
The primarily metabolic abnormality in type 2 diabetes mellitus (T2DM) is the defect in gluconeogenesis and glucose uptake. Itraconazole (ITCZ) is a traditional azole drug with anti-fungal and anticancer properties. However, limited attention has been directed towards the contribution of ITCZ to hepatic gluconeogenesis and glucose uptake in T2DM. The present study aimed to investigate the potential effects of ITCZ on hepatic gluconeogenesis and glucose uptake as well as the underlying mechanisms. No obvious change in cell viability was detected by MTT assay in HepG2 cells with ITCZ treatment at gradually increasing concentrations...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428299/g6pc-mrna-therapy-positively-regulates-fasting-blood-glucose-and-decreases-liver-abnormalities-in-a-mouse-model-of-glycogen-storage-disease-1a
#3
Daniel S Roseman, Tayeba Khan, Fabienne Rajas, Lucy S Jun, Kirtika H Asrani, Cleo Isaacs, Jeremiah D Farelli, Romesh R Subramanian
Glycogen storage disease type Ia (GSD1a) is an inherited metabolic disorder caused by the deficiency of glucose-6-phosphatase (G6Pase). GSD1a is associated with life-threatening hypoglycemia and long-term liver and renal complications. We examined the efficacy of mRNA-encoding human G6Pase in a liver-specific G6Pase -/- mouse model (L-G6PC -/- ) that exhibits the same hepatic biomarkers associated with GSD1a patients, such as fasting hypoglycemia, and elevated levels of hepatic glucose-6-phosphate (G6P), glycogen, and triglycerides...
January 31, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29362600/palmitate-induced-insulin-resistance-is-attenuated-by-pioglitazone-and-egcg-through-reducing-the-gluconeogenic-key-enzymes-expression-in-hepg2-cells
#4
S Yadollah, N Kazemipour, S Bakhtiyari, S Nazifi
HYPOTHESIS: Palmitate causes insulin resistance (IR) in insulin target tissue. Pioglitazone (an anti-hyperglycemic agent) and epigallocatechin gallate (EGCG, a dietary supplement) can be used for the treatment of type 2 diabetes. However, their molecular effects on gluconeogenesis remain unclear. OBJECTIVE: Hence, we aimed to investigate the simultaneous effect of these anti-hyperglycemic agents on gluconeogenesis through in vitro experiments. METHODS: HepG2 cells were treated with 0...
October 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29344818/dietary-chromium-picolinate-supplementation-affects-growth-whole-body-composition-and-gene-expression-related-to-glucose-metabolism-and-lipogenesis-in-juvenile-blunt-snout-bream-megalobrama-amblycephala
#5
Mingchun Ren, Ahmed Mokrani, Hualiang Liang, Ke Ji, Jun Xie, Xianping Ge, Bo Liu
An 11-week feeding trial was carried out to investigate the effects of supplemented chromium picolinate (Cr-Pic) on the growth, whole-body composition, and relative mRNA expression related to lipogenesis and glucose metabolism in juvenile blunt snout bream. Seven isonitrogenous and isoenergetic diets with graded Cr supplementation levels were fed to triplicate groups. The final weight (FW), feed conversion ratio (FCR), and specific growth rate (SGR) were improved with increasing dietary Cr supplementation levels up to 0...
January 18, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29327229/leopoldia-comosa-prevents-metabolic-disorders-in-rats-with-high-fat-diet-induced-obesity
#6
T Casacchia, F Scavello, C Rocca, M C Granieri, G Beretta, D Amelio, F Gelmini, A Spena, R Mazza, C C Toma, Tommaso Angelone, Giancarlo Statti, T Pasqua
PURPOSE: Obesity is the main feature of a complex illness known as metabolic syndrome. Anti-obesogenic therapies are often associated with side effects and represent a high cost in conventional pharmacological approaches. New strategies based on natural remedies are under continuous investigation. Leopoldia comosa (L.) Parl. (L. comosa) is a spontaneous plant with diuretic, anti-inflammatory and antioxidant properties. Recently, a hypoglycemic activity mediated by inhibition of carbohydrate digestion has been identified...
January 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29190746/hepatic-aryl-hydrocarbon-receptor-nuclear-translocator-arnt-regulates-metabolism-in-mice
#7
Christopher H Scott, Kuan-Minn Cha, Jason Ngai, Changtao Jiang, Kim Cheng, Rebecca A Stokes, Kenneth W K Ho, Jacob George, Frank J Gonzalez, Jenny E Gunton
BACKGROUND & AIMS: Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) and its partners hypoxia-inducible factors (HIF)-1α and HIF-2α are candidate factors for the well-known link between the liver, metabolic dysfunction and elevation in circulating lipids and glucose. Methods: Hepatocyte-specific ARNT-null (LARNT), HIF-1α-null (LHIF1α) and HIF-2α-null (LHIF2α) mice were created. RESULTS: LARNT mice had increased fasting glucose, impaired glucose tolerance, increased glucose production, raised post-prandial serum triglycerides (TG) and markedly lower hepatic ATP versus littermate controls...
2017: PloS One
https://www.readbyqxmd.com/read/29109794/ginsenoside-rg1-inhibits-glucagon-induced-hepatic-gluconeogenesis-through-akt-foxo1-interaction
#8
Qun Liu, Fei-Ge Zhang, Wen-Song Zhang, An Pan, Yi-Lin Yang, Jin-Feng Liu, Ping Li, Bao-Lin Liu, Lian-Wen Qi
Rationale: Glucagon is involved in hepatic gluconeogenesis, playing a key role in type 2 diabetes. Ginsenosides are reported to have antidiabetic activities. Ginsenoside Rg1 is a major propanaxatriol-type saponin in ginseng. This study aims to investigate the regulatory effects of Rg1 on glucagon-induced hepatic glucose production. Methods: The effects of Rg1 were investigated in high-fat-diet (HFD)-fed mice and glucagon-challenged C57BL/6J mice. Glucose metabolism was evaluated by oral glucose tolerance test and pyruvate tolerance test...
2017: Theranostics
https://www.readbyqxmd.com/read/29107025/association-of-changes-in-er-stress-mediated-signaling-pathway-with-lead-induced-insulin-resistance-and-apoptosis-in-rats-and-their-prevention-by-a-type-dimeric-epigallocatechin-3-gallate
#9
Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jiang
A-type dimeric epigallocatechin-3-gallate (A-type-EGCG-dimer, AEd), a new proanthocyanidins dimer from persimmon fruits, has been shown to have health benefit effects. However, A-type-EGCG-dimer affects gluose metabolism in the liver and the underlying mechanism is not clarified. The present study aims to examine the protective effects of A-type-EGCG-dimer on Pb-induced hepatic insulin resistance, endoplasmic reticulum (ER) stress and apoptosis in rats. Male wistar rats exposed to 0.05% w/v Pb acetate in the drinking water with or without A-type-EGCG-dimer coadministration (200 mg/kg body weight/day, intragastrically) for three months...
October 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29056338/selective-inhibition-of-foxo1-activator-repressor-balance-modulates-hepatic-glucose-handling
#10
Fanny Langlet, Rebecca A Haeusler, Daniel Lindén, Elke Ericson, Tyrrell Norris, Anders Johansson, Joshua R Cook, Kumiko Aizawa, Ling Wang, Christoph Buettner, Domenico Accili
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight coupling of these events poses a dual conundrum: mechanistically, as the FOXO1 corepressor of glucokinase is unknown, and clinically, as inhibition of glucose production is predicted to increase lipogenesis. Here, we report that SIN3A is the insulin-sensitive FOXO1 corepressor of glucokinase...
November 2, 2017: Cell
https://www.readbyqxmd.com/read/29035040/orally-administered-baker-s-yeast-%C3%AE-glucan-promotes-glucose-and-lipid-homeostasis-in-the-livers-of-obesity-and-diabetes-model-mice
#11
Yan Cao, Ying Sun, Siwei Zou, Mengxia Li, Xiaojuan Xu
Baker's yeast glucan (BYG) has been reported to be an anti-diabetic agent. In the work described herein, further study on the effect of orally administered BYG on glucose and lipid homeostasis in the livers of ob/ob mice was performed. It was found that BYG decreased the blood glucose and the hepatic glucose and lipid disorders. Western blotting analysis revealed that BYG up-regulated p-AKT and p-AMPK, and down-regulated p-Acc in the liver. Furthermore, RNA-Seq analysis indicated that BYG down-regulated genes responsible for gluconeogenesis (G6pase and Got1), fatty acid biosynthesis (Acly, Acc, Fas, etc...
October 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29028535/baicalin-and-its-metabolites-suppresses-gluconeogenesis-through-activation-of-ampk-or-akt-in-insulin-resistant-hepg-2-cells
#12
Tao Wang, Hongmei Jiang, Shijie Cao, Qian Chen, Mingyuan Cui, Zhijie Wang, Dandan Li, Jing Zhou, Tao Wang, Feng Qiu, Ning Kang
Scutellaria baicalensis Georgi (S. baicalensis), as a traditional Chinese herbal medicine, is an important component of several famous Chinese medicinal formulas for treating patients with diabetes mellitus. Baicalin (BG), a main bioactive component of S. baicalensis, has been reported to have antidiabetic effects. However, pharmacokinetic studies have indicated that BG has poor oral bioavailability. Therefore, it is hard to explain the pharmacological effects of BG in vivo. Interestingly, several reports show that BG is extensively metabolized in rats and humans...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29024108/changes-in-hepatic-glucose-and-lipid-metabolism-related-parameters-in-domestic-pigeon-columba-livia-during-incubation-and-chick-rearing
#13
X P Wan, P Xie, Z Bu, X T Zou
This study aimed to evaluate the hepatic glucose and lipid metabolism-related parameters of adult male and female White King pigeons (Columba livia) during incubation and chick rearing. At day 4 (I4), 10 (I10) and 17 (I17) of incubation and day 1 (R1), 7 (R7), 15 (R15) and 25 (R25) of chick rearing, livers were sampled from six pigeons for each sex. Glycogen and fat contents, activities of glycolytic enzymes (hexokinase, HK; 6-phosphofructokinase, 6-PFK), and genes expressions of key enzymes involved in glycolysis (pyruvate kinase, PK; glucokinase, GK), gluconeogenesis (phosphoenolpyruvate carboxykinase cytosolic, PCK1; fructose-1,6-bisphosphatase, FBP1; glucose-6-phosphatase, G6Pase), fatty acid synthesis (fatty acid synthase, FAS; acetyl-CoA carboxylase, ACC) and fatty acid β-oxidation (carnitine palmitoyltransferase 1, CPT1; acyl-CoA 1, ACO) were measured...
October 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28970780/mulberry-branch-bark-powder-significantly-improves-hyperglycemia-and-regulates-insulin-secretion-in-type-ii-diabetic-mice
#14
Xiao-Lu Yin, Hua-Yu Liu, Yu-Qing Zhang
This experiment, based on the previous study on R. mori, introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice to investigate hypoglycemic effects. After a 4-week period of diet consumption containing 5%, 10% and 20% MBBP, the fasting blood glucose, body weight and the related western blotting were measured, pathologic and immunohistochemical were observed. The 20% MBBP group showed a significant reduction in hyperglycemia and hyperinsulinemia; fasting blood glucose and insulin decreased from 25...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28951243/root-bark-extracts-of-myrianthus-arboreus-p-beauv-cecropiaceae-exhibit-anti-diabetic-potential-by-modulating-hepatocyte-glucose-homeostasis
#15
Pierre B Kasangana, Abir Nachar, Hoda M Eid, Tatjana Stevanovic, Pierre S Haddad
ETHNOPHARMACOLOGICAL RELEVANCE: Myrianthus arboreus P. Beauv. is a tropical tree used in African folk medicine, including for diabetes. However, little research has yet been conducted to support this ethnopharmacological use of this plant. The present study sought to determine the antidiabetic potential of root bark extracts through cell-based bioassays of liver and muscle glucose homeostasis. MATERIALS AND METHODS: Four extracts were obtained from crude root bark powder: 1 aqueous (AQ), 2 ethanol (EtOH), 3 alkaloid enriched (Alk) (obtained from methanol extract) and 4 dichloromethane (Dic) extracts...
September 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28911865/3-2-amino-ethyl-5-3-4-butoxyl-phenyl-propylidene-thiazolidine-2-4-dione-k145-ameliorated-dexamethasone-induced-hepatic-gluconeogenesis-through-activation-of-akt-foxo1-pathway
#16
Yanan Shi, Jiayun Qiao, Biao Mu, Bingfeng Zuo, Jihong Yuan
3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) is identified as a selective SphK2 inhibitor. It was previously reported as an anti-tumor agent, in this study we demonstrated that K145 was able to regulate hepatic gluconeogenesis and improve glucose intolerance in mice. C57BL/6 mice treated with dexamethasone injection were used as experimental animals, which exhibited impaired glucose tolerance and increased gluconeogenetic enzymes. After K145 treatment, we found that the impairment of glucose tolerance and gluconeogenetic genes mRNA expression were improved...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28901442/the-uptake-exploration-of-68ga-labeled-ngr-in-well-differentiated-hepatocellular-carcinoma-xenografts-indication-for-the-new-clinical-translational-of-a-tracer-based-on-ngr
#17
Yongheng Gao, Zhengjie Wang, Xiaowei Ma, Wenhui Ma, Mingxuan Zhao, Tianming Fu, Guoquan Li, Shengjun Wang, Zhe Wang, Weidong Yang, Fei Kang, Jing Wang
18F-FDG has low uptake and poor diagnostic efficiency in hepatocellular carcinoma (HCC), particularly in well-differentiated HCC. The NGR peptide selectively targets CD13, which is overexpressed in many types of tumor cells as well as neovasculature cells. In the present study, we aimed to evaluate the feasibility of utilizing 68Ga-NGR to image CD13-positive well-differentiated HCC xenografts. The in vitro cellular uptake, in vivo micro-PET/CT imaging and biodistribution studies of 68Ga-NGR and 18F-FDG were quantitatively compared in SMMC-7721-based well‑differentiated HCC xenografts...
November 2017: Oncology Reports
https://www.readbyqxmd.com/read/28900165/gcn5l1-modulates-cross-talk-between-mitochondria-and-cell-signaling-to-regulate-foxo1-stability-and-gluconeogenesis
#18
Lingdi Wang, Iain Scott, Lu Zhu, Kaiyuan Wu, Kim Han, Yong Chen, Marjan Gucek, Michael N Sack
The mitochondrial enriched GCN5-like 1 (GCN5L1) protein has been shown to modulate mitochondrial protein acetylation, mitochondrial content and mitochondrial retrograde signaling. Here we show that hepatic GCN5L1 ablation reduces fasting glucose levels and blunts hepatic gluconeogenesis without affecting systemic glucose tolerance. PEPCK and G6Pase transcript levels are downregulated in hepatocytes from GCN5L1 liver specific knockout mice and their upstream regulator, FoxO1 protein levels are decreased via proteasome-dependent degradation and via reactive oxygen species mediated ERK-1/2 phosphorylation...
September 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28832228/caffeic-acid-methyl-and-ethyl-esters-exert-potential-antidiabetic-effects-on-glucose-and-lipid-metabolism-in-cultured-murine-insulin-sensitive-cells-through-mechanisms-implicating-activation-of-ampk
#19
Hoda M Eid, Farah Thong, Abir Nachar, Pierre S Haddad
CONTEXT: Caffeic acid methyl (CAME) and ethyl (CAEE) esters stimulate glucose uptake and AMP-activated protein kinase (AMPK) in C2C12 myocytes (ATCC(®) CRL-1772(TM)). OBJECTIVE: Effects of CAME and CAEE were now assessed on myocyte glucose transporter GLUT4 activity and expression, on hepatic gluconeogenesis and on adipogenesis as well as major underlying signaling pathways. MATERIALS AND METHODS: GLUT4 protein translocation was studied in L6 GLUT4myc cells, glucose-6-phospatase (G6Pase) in H4IIE hepatocytes and adipogenesis in 3T3-L1 adipocytes...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28829278/glucose-6-phosphatase-%C3%AE-participates-in-dopaminergic-differentiation
#20
Jing Chen, Ting Wang, Xiao-Yan Zhou, Chuan-Xi Tang, Dian-Shuai Gao
OBJECTIVE:  Induction of dopaminergic (DA) differentiation is a cell-based therapy for Parkinson's disease (PD). Here, we explore the key factors of DA differentiation with a focus on glucose-6-phosphatase (G6Pase), a marker enzyme for the endoplasmic reticulum (ER) associated with cell differentiation. METHODS:  We cultured SH-SY5Y human neuroblastoma cells, a model system for PD research, and added glial cell-derived neurotrophic factor (GDNF; 25, 50, or 100 ng/ml) to stimulate differentiation...
August 22, 2017: Neurological Research
keyword
keyword
91910
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"