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https://www.readbyqxmd.com/read/27889947/pathological-findings-of-nash-and-nafld
#1
Kathryn Effendi, Kenichi Harada, Etsuko Hashimoto, Masayoshi Kage, Kazuhiko Koike, Fukuo Kondo, Masayuki Nakano, Hidenori Ojima, Takeshi Okanoue, Michiie Sakamoto, Yoshio Sumida, Hanako Tsujikawa, Gotaro Yamada, Yoh Zen
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common chronic liver disease worldwide. NAFLD comprises a variety of clinical and histopathological changes that can be broadly divided into nonalcoholic fatty liver (NAFL, simple steatosis) and nonalcoholic steatohepatitis (NASH). The differential diagnosis between NAFL and NASH is important because NASH is a more advanced form. This diagnosis therefore determines the prognosis and therapeutic management. At present the interpretation of NASH is made based on the histopathological features of steatohepatitis, i...
November 27, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27722159/nash-cirrhosis-the-new-burden-in-liver-transplantation-how-should-it-be-managed
#2
REVIEW
Ali Canbay, Jan-Peter Sowa, Wing-Kin Syn, Jürgen Treckmann
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a continuously increasing cause of chronic liver disease and a health burden in all populations affected by the obesity and metabolic syndrome pandemic. Cirrhotic alterations or hepatocellular carcinoma developing from NAFLD may require liver transplantation (LTx). METHODS: Current literature was screened for data on LTx in the setting of NAFLD. RESULTS: NAFLD-associated LTx is expected to increase in number and relevance during the next decade...
August 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27543499/non-alcoholic-fatty-liver-disease-in-2016
#3
REVIEW
S A Townsend, Philip N Newsome
INTRODUCTION: Non-alcoholic fatty liver disease is the commonest cause of liver disease worldwide, and is rapidly becoming the leading indication for liver transplantation. SOURCES OF DATA: Original articles, reviews and meta-analyses, guidelines. AREAS OF AGREEMENT: NAFLD strongly correlates with obesity and insulin resistance; currently, the best management strategy is weight loss and treatment of the metabolic syndrome. AREAS OF CONTROVERSY: Recent data suggest that the presence of fibrosis and not non-alcoholic steatohepatitis (NASH) is the predictor of clinical outcome...
September 2016: British Medical Bulletin
https://www.readbyqxmd.com/read/27465752/cardiometabolic-syndrome-in-people-with-spinal-cord-injury-disease-guideline-derived-and-nonguideline-risk-components-in-a-pooled-sample
#4
Mark S Nash, Rochelle E Tractenberg, Armando J Mendez, Maya David, Inger H Ljungberg, Emily A Tinsley, Patricia A Burns-Drecq, Luisa F Betancourt, Suzanne L Groah
OBJECTIVE: To assess cardiometabolic syndrome (CMS) risk definitions in spinal cord injury/disease (SCI/D). DESIGN: Cross-sectional analysis of a pooled sample. SETTING: Two SCI/D academic medical and rehabilitation centers. PARTICIPANTS: Baseline data from subjects in 7 clinical studies were pooled; not all variables were collected in all studies; therefore, participant numbers varied from 119 to 389. The pooled sample included men (79%) and women (21%) with SCI/D >1 year at spinal cord levels spanning C3-T2 (American Spinal Injury Association Impairment Scale [AIS] grades A-D)...
October 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27340992/the-agreement-between-protocols-for-the-investigation-of-asymmetrical-audiovestibular-symptoms
#5
Robert Nash, Anooj Majithia, Arvind Singh
OBJECTIVE: There are a number of published criteria for the investigation of asymmetrical audiovestibular symptoms. Our aim was to determine the agreement between these protocols when determining whether to investigate a group of patients treated at our institution. MATERIALS AND METHODS: Retrospective audit of the indications for arranging 854 consecutive magnetic resonance imaging scans of the internal auditory meatus. These indications were compared to the Oxford, Northern, Charing Cross, and Nashville guidelines on the investigation of asymmetrical audiovestibular symptoms...
April 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27338480/surveillance-for-hepatocellular-carcinoma-in-patients-with-nash
#6
REVIEW
Philippe Kolly, Jean-François Dufour
European and American guidelines recommend surveillance for hepatocellular carcinoma (HCC) by performing ultrasonography on a six-month basis on an at risk population, defined by presence of cirrhosis. HCC, due to non-alcoholic steatohepatitis (NASH), is rising. Patients with NASH have a high risk of developing HCC and, therefore, have to be enrolled in a screening program. One of the challenges with NASH-induced HCC is that half of the cases arise in non-cirrhotic patients. There is a need to identify those patients in order to screen them for HCC...
June 7, 2016: Diagnostics
https://www.readbyqxmd.com/read/27308649/real-life-perception-and-practice-patterns-of-nafld-nash-in-romania-results-of-a-survey-completed-by-102-board-certified-gastroenterologists
#7
Speranta Iacob, Carmen Ester, Mihaela Lita, Vlad Ratziu, Liana Gheorghe
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) has an increasing incidence worldwide, reflecting the epidemics of obesity and metabolic syndrome. Data on knowledge, attitude and management by the Romanian gastroenterologists with regard to NAFLD are lacking. METHODS: We assessed current diagnostic and treatment patterns of the management of NAFLD among 102 Romanian board certified gastroenterologists using a survey developed to collect information regarding participants' clinical practice, diagnostic tools and usage of medication in patients with NAFLD...
June 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27052013/lifestyle-and-dietary-interventions-in-the-management-of-nonalcoholic-fatty-liver-disease
#8
REVIEW
William N Hannah, Stephen A Harrison
NAFLD is the leading cause of chronic liver disease in the Western world with an estimated prevalence of 20-30 %. Lifestyle interventions targeted at weight loss through dietary interventions and exercise are the most effective treatment, but only a minority of patients are able to achieve and sustain the necessary intervention targets. Weight loss of 3-5 % has been associated with a reduction of hepatic steatosis while weight loss of ≥5-7 % has correlated with resolution of NASH in some studies. Greater reductions in weight loss (≥10 %) may improve hepatic fibrosis...
May 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26984711/prolonged-exposure-to-low-dose-microcystin-induces-nonalcoholic-steatohepatitis-in-mice-a-systems-toxicology-study
#9
Jun He, Guangyu Li, Jun Chen, Juan Lin, Cheng Zeng, Jing Chen, Junliang Deng, Ping Xie
Microcystin-LR (MCLR), a cyanotoxin widely present in freshwater, has been shown to have potent acute hepatotoxicity. However, the chronic toxicity of low-dose MCLR remains confusing by traditional measurements of toxicity. This has impeded understanding of the chronic liver damage of low-dose MCLR and corresponding safety risks of the human exposure guideline value. Here, iTRAQ-based proteomics and NMR-based metabonomics were used to decipher the molecular toxicological signatures of low doses of MCLR in mice exposed to this agent for 90 days...
March 16, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/26838973/nonalcoholic-steatohepatitis-diagnostic-challenges
#10
Ryan M Gill, Sanjay Kakar
This article reviews diagnostic criteria for nonalcoholic steatohepatitis (NASH), current grading and staging methodology, and diagnostic challenges and pitfalls in routine practice. Current practice guidelines and prognostic and treatment considerations are discussed. The clinical diagnosis of nonalcoholic fatty liver disease may represent stable disease without progressive liver damage, in the form of nonalcoholic fatty liver (NAFL), or aggressive disease that will progress to advanced fibrosis, in the form of NASH...
June 2013: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26825843/screening-for-nonalcoholic-steatohepatitis-in-individuals-with-type-2-diabetes-a-cost-effectiveness-analysis
#11
Kathleen E Corey, Matthew J Klebanoff, Angela C Tramontano, Raymond T Chung, Chin Hur
BACKGROUND AND AIM: Individuals with type 2 diabetes are at heightened risk for nonalcoholic fatty liver disease, which gives rise to nonalcoholic steatohepatitis (NASH) and cirrhosis. Yet, current guidelines do not recommend screening for NASH among these high-risk patients. Using a simulation model, we assessed the effectiveness and cost-effectiveness of screening diabetic patients for NASH. METHODS: A Markov model was constructed to compare two management strategies for 50-year-olds with diabetes...
July 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26770262/practice-patterns-in-nafld-and-nash-real-life-differs-from-published-guidelines
#12
Mary E Rinella, Zurabi Lominadze, Rohit Loomba, Michael Charlton, Brent A Neuschwander-Tetri, Stephen H Caldwell, Kris Kowdley, Stephen A Harrison
BACKGROUND: Management guidelines from the American Association for the Study of Liver Diseases/American College of Gastroenterology/American Gastroenterology Association published in 2012 for nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) recommend weight loss, vitamin E and pioglitazone as effective therapies for the treatment of biopsy-confirmed NASH. However, little is known about how physicians in the US diagnose NASH or whether published guidelines are being followed...
January 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/26497495/organ-preservation-in-rectal-adenocarcinoma-a-phase-ii-randomized-controlled-trial-evaluating-3-year-disease-free-survival-in-patients-with-locally-advanced-rectal-cancer-treated-with-chemoradiation-plus-induction-or-consolidation-chemotherapy-and-total-mesorectal
#13
RANDOMIZED CONTROLLED TRIAL
J Joshua Smith, Oliver S Chow, Marc J Gollub, Garrett M Nash, Larissa K Temple, Martin R Weiser, José G Guillem, Philip B Paty, Karin Avila, Julio Garcia-Aguilar
BACKGROUND: Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodality treatment provides local tumor control in most patients; but almost one-third ultimately die from distant metastasis. Most survivors experience significant impairment in quality of life (QoL), due primarily to removal of the rectum. A current challenge lies in identifying patients who could safely undergo rectal preservation without sacrificing survival benefit and QoL...
October 23, 2015: BMC Cancer
https://www.readbyqxmd.com/read/26447642/nonalcoholic-fatty-liver-disease-and-fibrosis-in-youth-taking-psychotropic-medications-literature-review-case-reports-and-management
#14
REVIEW
Barbara L Gracious, Ramona Bhatt, Carol Potter
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic because of the greater prevalence of obesity. Despite implications for youth with severe mental disorders, little has been published in the psychiatric literature about this increasingly common medical comorbidity. The goals of this article are to: 1) provide an overview of the epidemiology and pathophysiology of NAFLD, including progression to nonalcoholic steatohepatitis (NASH); 2) describe two clinical cases illustrating difficulties faced in management; and 3) review screening recommendations, differential diagnosis, and monitoring and intervention approaches...
October 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26334449/aplar-rheumatoid-arthritis-treatment-recommendations
#15
REVIEW
Chak Sing Lau, Faith Chia, Andrew Harrison, Tsu-Yi Hsieh, Rahul Jain, Seung Min Jung, Mitsumasa Kishimoto, Ashok Kumar, Khai Pang Leong, Zhanguo Li, Juan Javier Lichauco, Worawit Louthrenoo, Shue-Fen Luo, Peter Nash, Chin Teck Ng, Sung-Hwan Park, Bagus Putu Putra Suryana, Parawee Suwannalai, Linda Kurniaty Wijaya, Kazuhiko Yamamoto, Yue Yang, Swan Sim Yeap
AIMS: Rheumatoid arthritis is a chronic inflammatory condition that affects approximately 1% of the world's population. There are a wide number of guidelines and recommendations available to support the treatment of rheumatoid arthritis; however, the evidence used for these guidelines is predominantly based on studies in Caucasian subjects and may not be relevant for rheumatoid arthritis patients in the Asia-Pacific region. Therefore, the Asia Pacific League of Associations for Rheumatology established a Steering Committee in 2013 to address this issue...
September 2015: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/26314837/prevalence-of-nonalcoholic-steatohepatitis-in-japanese-patients-with-morbid-obesity-undergoing-bariatric-surgery
#16
Yosuke Seki, Satoru Kakizaki, Norio Horiguchi, Hiroaki Hashizume, Hiroki Tojima, Yuichi Yamazaki, Ken Sato, Motoyasu Kusano, Masanobu Yamada, Kazunori Kasama
BACKGROUND: Patients with morbid obesity selected for bariatric surgery have a high prevalence of nonalcoholic steatohepatitis (NASH); however, the incidence is varied and depends on race. The prevalence of NASH in obese Japanese patients is unknown. We evaluated the prevalence of NASH in a prospective cohort of Japanese patients with morbid obesity. METHODS: From October 2009 to July 2011, consecutive patients requiring bariatric surgery underwent a liver biopsy during the operation...
March 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26219858/recommendations-for-diagnosis-referral-for-liver-biopsy-and-treatment-of-nonalcoholic-fatty-liver-disease-and-nonalcoholic-steatohepatitis
#17
REVIEW
Erin K Spengler, Rohit Loomba
Nonalcoholic fatty liver disease (NAFLD) is the primary cause of chronic liver disease in the United States, afflicting an estimated 80 to 100 million Americans. Nonalcoholic fatty liver disease is a spectrum of liver diseases composed of nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH). Although nonalcoholic fatty liver has a negligible risk of progression, patients with NASH often develop cirrhosis or hepatocellular carcinoma. Although liver biopsy is required to diagnose NASH, only patients with a high risk of NASH or advanced fibrosis require this evaluation...
September 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26160253/how-close-are-we-to-achieving-energy-and-nutrient-goals-for-very-low-birth-weight-infants-in-the-first-week
#18
Dawn V Y Ng, Joan Brennan-Donnan, Sharon Unger, Nicole Bando, Sharyn Gibbins, Andrea Nash, Alex Kiss, Deborah L O'Connor
BACKGROUND: Emerging evidence suggests intakes of protein and energy as early as the first week of life in preterm very low birth weight (VLBW) infants are associated with improved neurodevelopment. In response, many neonatal intensive care units (NICUs) have launched new, more aggressive early feeding guidelines. The aim of this study was to evaluate enteral and parenteral energy and macronutrient intakes during the first postnatal week in VLBW infants admitted to NICUs that have introduced more aggressive early feeding guidelines...
July 9, 2015: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25919868/-molecular-bases-of-%C3%AE-thalassemia-in-argentina
#19
Karen G Scheps, Liliana Francipane, Abigail Nash, Gloria E Cerrone, Silvia B Copelli, Viviana Varela
The α-thalassemia is one of the most common hereditary disorders worldwide. Currently, molecular diagnostics is the only available tool to achieve an accurate diagnosis. The purpose of this study was to characterize the molecular bases of these syndromes in our environment and to establish genotype-phenotype associations. Through a combination of different molecular techniques and fluorescent in situ hybridization (FISH),we were able to find α-thalassemic mutations in 145 of the 184 patients (78.8%) studied with hematological parameters compatible with α-thalassemia...
2015: Medicina
https://www.readbyqxmd.com/read/25887357/clinical-model-for-nash-and-advanced-fibrosis-in-adult-patients-with-diabetes-and-nafld-guidelines-for-referral-in-nafld
#20
Jessica Bazick, Michele Donithan, Brent A Neuschwander-Tetri, David Kleiner, Elizabeth M Brunt, Laura Wilson, Ed Doo, Joel Lavine, James Tonascia, Rohit Loomba
OBJECTIVE: Approximately 18 million people in the U.S. have coexisting type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). It is not known who among these patients has nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Therefore, we aimed to determine factors that are associated with both NASH and advanced fibrosis in patients with diabetes and NAFLD in order to identify who should be prioritized for referral to a hepatologist for further diagnostic evaluation and treatment...
July 2015: Diabetes Care
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