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https://www.readbyqxmd.com/read/28089907/adenosine-and-preeclampsia
#1
REVIEW
Rocío Salsoso, Marcelo Farías, Jaime Gutiérrez, Fabián Pardo, Delia I Chiarello, Fernando Toledo, Andrea Leiva, Alfonso Mate, Carmen M Vázquez, Luis Sobrevia
Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, adenosine receptors, and corresponding intracellular signalling network associate with development of pathologies of pregnancy, including preeclampsia. Preeclampsia is a cause of maternal and perinatal morbidity and mortality affecting 3-5% of pregnancies. Since the proposed mechanisms of preeclampsia development include adenosine-dependent biological effects, adenosine membrane transporters and receptors, and the associated signalling mechanisms might play a role in the pathophysiology of preeclampsia...
January 12, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28070244/assessment-of-fetus-during-second-trimester-ultrasonography-using-hdlive-software-what-is-its-real-application-in-the-obstetrics-clinical-practice
#2
Gabriele Tonni, Gianpaolo Grisolia, Eduardo Félix Santana, Edward Araujo Júnior
AIM: To show imaging results from application of four-dimensional (4D) ultrasound lightening technique (HDlive™) in clinical obstetrics practice. METHODS: Normal and abnormal fetuses at second and third trimester of pregnancy undergoing routine scan with 4D HDlive™ (5DUS) in the rendering mode are described. Realistic features of fetal structures were provided by 5DUS in the rendering mode. Normal anatomy as well as pathology like cleft lip, hypoplastic face, micrognathia, low-set ears, corpus callosum, arthrogryposis, aortic arch, left congenital diaphragmatic hernia are highlighted in this study...
December 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/28063749/symmetrical-thalamic-calcification-a-trio-whole-exome-sequencing-negative-series
#3
Kathleen Mary Gorman, John James Aird, Judith Conroy, Deirdre Devaney, Michael Farrell, Mary Dolores King
Symmetrical thalamic calcification or bilateral symmetrical thalamic gliosis presents at delivery with hypertonia, fixed flexion contractures and prominent bulbar signs, without preceding perinatal asphyxia. At post-mortem, there is evidence of bilateral symmetrical selective thalamic neuronal encrustation and gliosis. To date, 27 cases are published with no underlying diagnosis identified. Two affected children from singleton pregnancies were reported and therefore, a genetic cause proposed. No previous reports have performed genetic testing to confirm or reject this hypothesis...
January 4, 2017: Brain & Development
https://www.readbyqxmd.com/read/28044203/advances-with-neonatal-aerodigestive-science-in-the-pursuit-of-safe-swallowing-in-infants-invited-review
#4
Sudarshan R Jadcherla
Feeding, swallowing, and airway protection are three distinct entities. Feeding involves a process of sequential, neurosensory, and neuromotor interactions of reflexes and behaviors facilitating ingestion. Swallowing involves anterograde bolus movement during oral-, pharyngeal-, and esophageal phases of peristalsis into stomach. During these events, coordination with airway protection is vital for homeostasis in clearing any material away from airway vicinity. Neurological-airway-digestive inter-relationships are critical to the continuum of successful feeding patterns during infancy, either in health or disease...
January 2, 2017: Dysphagia
https://www.readbyqxmd.com/read/28012571/perinatal-nutrition-interventions-and-post-partum-depressive-symptoms
#5
REVIEW
Jacqueline F Gould, Karen Best, Maria Makrides
BACKGROUND: Postpartum depression (PPD) is the most prevalent mood disorder associated with childbirth. No single cause of PPD has been identified, however the increased risk of nutritional deficiencies incurred through the high nutritional requirements of pregnancy may play a role in the pathology of depressive symptoms. Three nutritional interventions have drawn particular interest as possible non-invasive and cost-effective prevention and/or treatment strategies for PPD; omega-3 (n-3) long chain polyunsaturated fatty acids (LCPUFA), vitamin D and overall diet...
December 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27984133/perinatal-exposure-to-lead-pb-induces-ultrastructural-and-molecular-alterations-in-synapses-of-rat-offspring
#6
Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Lidia Strużyńska, Izabela Gutowska, Dariusz Chlubek, Agata Adamczyk
Lead (Pb), environmentally abundant heavy-metal pollutant, is a strong toxicant for the developing central nervous system. Pb intoxication in children, even at low doses, is found to affect learning and memorizing, with devastating effects on cognitive function and intellectual development. However, the precise mechanism by which Pb impairs synaptic plasticity is not fully elucidated. The purpose of this study was to investigate the effect of pre- and neonatal exposure to low dose of Pb (with Pb concentrations in whole blood below 10μg/dL) on the synaptic structure and the pre- and postsynaptic proteins expression in the developing rat brain...
October 29, 2016: Toxicology
https://www.readbyqxmd.com/read/27974193/perinatal-exposure-to-lead-pb-induces-ultrastructural-and-molecular-alterations-in-synapses-of-rat-offspring
#7
Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Lidia Strużyńska, Izabela Gutowska, Dariusz Chlubek, Agata Adamczyk
Lead (Pb), environmentally abundant heavy-metal pollutant, is a strong toxicant for the developing central nervous system. Pb intoxication in children, even at low doses, is found to affect learning and memorizing, with devastating effects on cognitive function and intellectual development. However, the precise mechanism by which Pb impairs synaptic plasticity is not fully elucidated. The purpose of this study was to investigate the effect of pre- and neonatal exposure to low dose of Pb (with Pb concentrations in whole blood below 10μg/dL) on the synaptic structure and the pre- and postsynaptic proteins expression in the developing rat brain...
December 12, 2016: Toxicology
https://www.readbyqxmd.com/read/27958319/altered-dna-methylation-associated-with-an-abnormal-liver-phenotype-in-a-cattle-model-with-a-high-incidence-of-perinatal-pathologies
#8
Hélène Kiefer, Luc Jouneau, Évelyne Campion, Delphine Rousseau-Ralliard, Thibaut Larcher, Marie-Laure Martin-Magniette, Sandrine Balzergue, Mireille Ledevin, Audrey Prézelin, Pascale Chavatte-Palmer, Yvan Heyman, Christophe Richard, Daniel Le Bourhis, Jean-Paul Renard, Hélène Jammes
Cloning enables the generation of both clinically normal and pathological individuals from the same donor cells, and may therefore be a DNA sequence-independent driver of phenotypic variability. We took advantage of cattle clones with identical genotypes but different developmental abilities to investigate the role of epigenetic factors in perinatal mortality, a complex trait with increasing prevalence in dairy cattle. We studied livers from pathological clones dying during the perinatal period, clinically normal adult clones with the same genotypes as perinatal clones and conventional age-matched controls...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27925050/fetal-thrombotic-vasculopathy-a-case-report-and-literature-review
#9
Ana Berquo Peleja, Silvio Martinelli, Renata Lopes Ribeiro, Roberto Eduardo Bittar, Regina Schultz, Rossana Pulcineli Vieira Francisco
Introduction: Fetal thrombotic vasculopathy is a recently described placental alteration with varying degrees of involvement and often associated with adverse perinatal outcomes. The diagnosis is made histologically and therefore is postnatal, which makes it a challenge in clinical practice. Method: Case report and review of literature on the subject. Results: The present case refers to a pregnant woman presenting fetal growth restriction, with poor obstetrical past, and sent late to our service...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27913050/congenital-high-airway-obstruction-syndrome-chaos-a-perinatal-autopsy-case-report
#10
Manasi Gosavi, Lalit Kumar, Ashwini Ratnakar, Hema Bannur
INTRODUCTION: Congenital High Airway Obstruction Syndrome (CHAOS) is a rare anomaly where a partial or complete obstruction of upper airway is seen. As a consequence, the foetus develops enlarged lungs, inverted or flattened diaphragm and ascites. The pathological findings in a case of CHAOS is presented. CASE REPORT: A 28-year-old primigravida presented with a history of 5 months of amenorrhoea. Ultrasonography revealed enlarged echogenic lungs, cardiac mid-position, inverted diaphragm, foetal ascites and talipes of left foot...
October 26, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27905648/-a-new-fetal-death-classification-system
#11
Alfredo Ovalle, Ariel Fuentes, Valentina Chacón, Carolina Espinoza, Rodrigo González, Manuel Ramos, Jorge Geraldo, Letsy Osses, Elena Kakarieka
BACKGROUND: Stillbirth is the mayor contributor to perinatal mortality. AIM: To report a system for classification of fetal deaths. MATERIAL AND METHODS: Retrospective cohort study of 29,916 births with 258 fetal deaths that occurred in a public hospital. Data were obtained from audit reports of stillbirths. The method for classification “obstetric condition relevant to the death” was applied, based on obstetric and placental pathological findings analyzed exclusively by a single obstetrician and a single pathologist...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27894129/isolated-fetal-ascites-neonatal-outcome-in-51-cases-observed-in-a-tertiary-referral-center
#12
Vincenzo Davide Catania, Alessia Muru, Marcella Pellegrino, Erika Adalgisa De Marco, Filomena Valentina Paradiso, Carlo Manzoni, Lorenzo Nanni, Lucia Masini
Introduction Prenatal detection of isolated ascites is a rare finding on ultrasound, usually suggestive of an underlying pathology that may negatively impact on the pregnancy and neonatal outcome. The purpose of the present study was to evaluate the outcome of primary isolated ascites in relation to gestational age (GA) at diagnosis. Materials and Methods Data were prospectively collected for fetuses with ascites that have been followed in our center of prenatal diagnosis and therapy from 2004 to 2014. Patients have been divided in group I when ascites was detected before the 24th week of GA and group II if it was noticed later...
November 28, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27881627/sleep-related-hypermotor-epilepsy-long-term-outcome-in-a-large-cohort
#13
Laura Licchetta, Francesca Bisulli, Luca Vignatelli, Corrado Zenesini, Lidia Di Vito, Barbara Mostacci, Claudia Rinaldi, Irene Trippi, Ilaria Naldi, Giuseppe Plazzi, Federica Provini, Paolo Tinuper
OBJECTIVE: To assess the long-term outcome of sleep-related hypermotor epilepsy (SHE). METHODS: We retrospectively reconstructed a representative cohort of patients diagnosed with SHE according to international diagnostic criteria, sleep-related seizures ≥75% and follow-up ≥5 years. Terminal remission (TR) was defined as a period of ≥5 consecutive years of seizure freedom at the last follow-up. We used Kaplan-Meier estimates to calculate the cumulative time-dependent probability of TR and to generate survival curves...
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/27855149/placental-pathology-and-hypospadias
#14
Yan Chen, Luming Sun, Hongquan Geng, Xiaoping Lei, Jun Zhang
BACKGROUND: Studies have shown that hypospadias is associated with placenta-mediated pregnancy complication (PMPC). The role of placental lesions is still unclear. We aimed to examine the association between hyposadias and placental pathology, and the effect of PMPC. METHODS: Using data from the U.S. Collaborative Perinatal Project in 1959-1966, we identified 15,780 male subjects (167 hypospadias) for analysis. Detailed placental examinations were conducted following a standard protocol...
November 17, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27847193/extremely-low-gestational-age-and-very-low-birthweight-for-gestational-age-are-risk-factors-for-autism-spectrum-disorder-in-a-large-cohort-study-of-10-year-old-children-born-at-23-27-weeks-gestation
#15
Robert M Joseph, Steven J Korzeniewski, Elizabeth N Allred, T Michael O'Shea, Tim Heeren, Jean A Frazier, Janice Ware, Deborah Hirtz, Alan Leviton, Karl Kuban
BACKGROUND: No prospective cohort study of high-risk children has used rigorous exposure assessment and optimal diagnostic procedures to examine the perinatal antecedents of autism spectrum disorder separately among those with and without cognitive impairment. OBJECTIVE: We sought to identify perinatal factors associated with increased risk for autism spectrum disorder with and without intellectual disability (intelligence quotient <70) in children born extremely preterm...
November 12, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27843854/clinical-study-of-fundus-findings-in-pregnancy-induced-hypertension
#16
Rahul Navinchandra Bakhda
BACKGROUND AND OBJECTIVES: To study the role of ophthalmoscopy in pregnancy induced hypertension (PIH) in diagnosis, prognosis, differential diagnosis, line of treatment and effect of treatment. MATERIALS AND METHODS: An observational study in which all the patients for the study are selected from antenatal clinic, antenatal wards and preeclampsia and eclampsia room in Department of Obstetrics and Gynecology, General Ophthalmic Out Patient Department (OPD) in case of ambulatory patients, during the period of Nov...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27818357/the-role-of-neuropathological-markers-in-the-interpretation-of-neuropsychiatric-disorders-focus-on-fetal-and-perinatal-programming
#17
REVIEW
Fanni Daniela, Gerosa Clara, Rais Monica, Ravarino Alberto, Van Eyken Peter, Fanos Vassilios, Faa Gavino
The study of neuropathological markers in patients affected by mental/psychiatric disorders is relevant for the comprehension of the pathogenesis and the correlation with the clinical symptomatology. The neuropathology of Alzheimer's disease (AD) recognizes intraneuronal and extracellular neurofibrillary formation responsible for neuronal degeneration. Immunohistochemical studies discovered many interesting results for a better interpretation of the AD pathogenesis, while the "metal hypothesis" supports that metal ions might differentially influence the formation of amyloid aggregates...
November 3, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27795844/hyaluronic-acid-in-vascular-and-immune-homeostasis-during-normal-pregnancy-and-preeclampsia
#18
M M Ziganshina, S V Pavlovich, N V Bovin, G T Sukhikh
Preeclampsia (PE) is a multisystem pathologic state that clinically manifests itself after the 20th week of pregnancy. It is characterized by high maternal and perinatal morbidity and mortality. According to modern concepts, the impairment of trophoblast invasion into maternal spiral arteries, leading to the development of ischemia in placenta, is considered to be the major pathogenetic factor of PE development. Ischemic lesions initiate the development of a systemic inflammatory response (SIR) and endothelial dysfunction, which is the main cause of the multiple organ failure in PE...
July 2016: Acta Naturae
https://www.readbyqxmd.com/read/27788335/pathologist-effort-in-the-performance-of-fetal-perinatal-and-pediatric-autopsies-a-survey-of-practice
#19
M Cristina Pacheco, Robyn C Reed
CONTEXT: -Autopsy is an important tool for quality assurance and improving patient care. Fetal, perinatal, and pediatric autopsies have the additional benefit of identifying conditions that may have increased risk of recurrence. In contrast to adult autopsies, special collections and testing are frequently used. Pathologist effort in fetal, perinatal, and pediatric autopsy has not been well documented. OBJECTIVE: -To prospectively quantify pathologist time required to complete fetal, perinatal, and pediatric autopsies, and to gather information on special studies and whether or not a cause of death was identified...
October 27, 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27788142/the-pre-eclampsia-ontology-a-disease-ontology-representing-the-domain-knowledge-specific-to-pre-eclampsia
#20
Satoshi Mizuno, Soichi Ogishima, Hidekazu Nishigori, Daniel G Jamieson, Karin Verspoor, Hiroshi Tanaka, Nobuo Yaegashi, Jun Nakaya
Pre-eclampsia (PE) is a clinical syndrome characterized by new-onset hypertension and proteinuria at ≥20 weeks of gestation, and is a leading cause of maternal and perinatal morbidity and mortality. Previous studies have gathered abundant data about PE such as risk factors and pathological findings. However, most of these data are not semantically structured. Clinical data on PE patients are often generated with semantic heterogeneity such as using disparate terminology to describe the same phenomena. In clinical studies, interoperability of heterogenic clinical data is required in various situations...
2016: PloS One
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