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https://www.readbyqxmd.com/read/29664514/-damage-control-resuscitation-in-pediatric-severe-trauma
#1
Adriana Wegner Araya
INTRODUCTION: Trauma is an important cause of morbidity and mortality in the pediatric population. It has the first place in mortality in our country without considering perinatal pathologies and congenital malformations. An important percentage of early and late deaths secondary to this cau se, as well as its sequelae, could be prevented with optimal and timely resuscitation. OBJECTIVE: To review the applicability of damage control resuscitation (DCR) in severe pediatric trauma, with emphasis on medical management...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29663692/profiles-of-gene-expression-in-the-hippocampal-formation-of-rats-with-experimentally-induced-brain-dysplasia
#2
Michal Kielbinski, Zuzanna Setkowicz, Kinga Gzielo, Krzysztof Janeczko
Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All types exhibit disturbed cortical cytoarchitecture and increased propensity for seizures. The etiology is likely heterogenous, with mutations, specifically in genes related to mammalian target of rapamycin (mTOR), identified in only a subset of cases...
April 16, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29656674/psycho-social-approach-of-perinatal-palliative-care
#3
Barthélémy Tosello, Lionel Dany
The diagnosis of some of these antenatal pathologies is difficult to reconcile with post-natal survival. Indeed, the diagnosis and management of pregnancies complicated by lethal fetal abnormalities (LFA) pose a challenge for both the parents and the clinicians. The practices discussed are characterized by the multiple challenges involved (on professional, informational, human, and ethical levels) and question the necessity and validity of a multidisciplinary approach. Revealing professional experiences and practices and the biopsychosocial processes behind them could prove useful in advancing attitudes toward LFA, how it is managed, and the care options available...
April 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29629602/deactivation-of-mitochondrial-complex-i-after-hypoxia-ischemia-in-the-immature-brain
#4
Anna Stepanova, Csaba Konrad, Sergio Guerrero-Castillo, Giovanni Manfredi, Susan Vannucci, Susanne Arnold, Alexander Galkin
Mortality from perinatal hypoxic-ischemic (HI) brain injury reached 1.15 million worldwide in 2010 and is also a major factor for neurological disability in infants. HI directly influences the oxidative phosphorylation enzyme complexes in mitochondria, but the exact mechanism of HI-reoxygenation response in brain remains largely unresolved. After induction of HI-reoxygenation in postnatal day 10 rats, activities of mitochondrial respiratory chain enzymes were analysed and complexome profiling was performed...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29628394/interleukin-6-regulates-adult-neural-stem-cell-numbers-during-normal-and-abnormal-post-natal-development
#5
Mekayla A Storer, Denis Gallagher, Michael P Fatt, Jaclin V Simonetta, David R Kaplan, Freda D Miller
Circulating systemic factors can regulate adult neural stem cell (NSC) biology, but the identity of these circulating cues is still being defined. Here, we have focused on the cytokine interleukin-6 (IL-6), since increased circulating levels of IL-6 are associated with neural pathologies such as autism and bipolar disorder. We show that IL-6 promotes proliferation of post-natal murine forebrain NSCs and that, when the IL-6 receptor is inducibly knocked out in post-natal or adult neural precursors, this causes a long-term decrease in forebrain NSCs...
April 3, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29615958/lymphocytes-contribute-to-the-pathophysiology-of-neonatal-brain-injury
#6
Arshed Nazmi, Anna-Maj Albertsson, Eridan Rocha-Ferreira, Xiaoli Zhang, Regina Vontell, Aura Zelco, Mary Rutherford, Changlian Zhu, Gisela Nilsson, Carina Mallard, Henrik Hagberg, Jacqueline C Y Lai, Jianmei W Leavenworth, Xiaoyang Wang
Background: Periventricular leukomalacia (PVL) is the most common form of preterm brain injury affecting the cerebral white matter. This type of injury involves a multiphase process and is induced by many factors, including hypoxia-ischemia (HI) and infection. Previous studies have suggested that lymphocytes play a significant role in the pathogenesis of brain injury, and the aim of this study was to determine the contribution of lymphocyte subsets to preterm brain injury. Methods: Immunohistochemistry on brain sections from neonatal mice was performed to evaluate the extent of brain injury in wild-type and T cell and B cell-deficient neonatal mice ( Rag1 -/- mice) using a mouse model of HI-induced preterm brain injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29614446/intrapartum-and-perinatal-results-associated-with-different-degrees-of-staining-of-meconium-stained-amniotic-fluid
#7
Vanesa Rodríguez Fernández, Carlos Nicolás López Ramón Y Cajal, Elena Marín Ortiz, Emilio Couceiro Naveira
OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29610829/association-of-histologic-chorioamnionitis-with-perinatal-brain-injury-and-early-childhood-neurodevelopmental-outcomes-among-preterm-neonates
#8
Daniel Bierstone, Nienke Wagenaar, Dawn L Gano, Ting Guo, Gregory Georgio, Floris Groenendaal, Linda S de Vries, Jojy Varghese, Hannah C Glass, Catherine Chung, Jefferson Terry, Maarten Rijpert, Ruth E Grunau, Anne Synnes, A James Barkovich, Donna M Ferriero, Manon Benders, Vann Chau, Steven P Miller
Importance: Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. Objective: To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood...
April 2, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29608930/atomoxetine-a-selective-norepinephrine-reuptake-inhibitor-improves-short-term-histological-outcomes-after-hypoxic-ischemic-brain-injury-in-the-neonatal-male-rat
#9
Masatake Toshimitsu, Yoshimasa Kamei, Mari Ichinose, Takahiro Seyama, Shinya Imada, Takayuki Iriyama, Tomoyuki Fujii
BACKGROUND: Despite the recent progress of perinatal medicine, perinatal hypoxic-ischemic (HI) insult remains an important cause of brain injury in neonates, and is pathologically characterized by neuronal loss and the presence of microglia. Neurotransmitters, such as norepinephrine (NE) and glutamate, are involved in the pathogenesis of hypoxic-ischemic encephalopathy via the interaction between neurons and microglia. Although it is well known that the monoamine neurotransmitter NE acts as an anti-inflammatory agent in the brain under pathological conditions, its effects on perinatal HI insult remains elusive...
March 30, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29580679/accuracy-of-pulse-oximetry-screening-for-critical-congenital-heart-defects-after-home-birth-and-early-postnatal-discharge
#10
Ilona C Narayen, Nico A Blom, Nan van Geloven, Ellen I M Blankman, Annique J M van den Broek, Martijn Bruijn, Sally-Ann B Clur, Frank A van den Dungen, Hester M Havers, Henriëtte van Laerhoven, Shahryar E Mir, Moira A Muller, Odette M Polak, Lukas A J Rammeloo, Gracita Ramnath, Sophie R D van der Schoor, Anton H van Kaam, Arjan B Te Pas
OBJECTIVE: To assess the accuracy of pulse oximetry screening for critical congenital heart defects (CCHDs) in a setting with home births and early discharge after hospital deliveries, by using an adapted protocol fitting the work patterns of community midwives. STUDY DESIGN: Pre- and postductal oxygen saturations (SpO2 ) were measured ≥1 hour after birth and on day 2 or 3. Screenings were positive if the SpO2 measurement was <90% or if 2 independent measures of pre- and postductal SpO2 were <95% and/or the pre-/postductal difference was >3%...
March 23, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29577494/placenta-immune-infiltrates-and-perinatal-outcomes
#11
Maide Ozen, Christopher Novak, Irina Burd
Pregnancy is a state of immunotolerance and loss of this immunotolerance may lead to fetal rejection, pregnancy complications, and neonatal complications. Immunobiology of pregnancy is complex and involves unique immune cell populations specific to pregnancy, changes in mucosal immune cells and peripheral immune system, and reciprocal adaptations between the mother and the fetus. The mechanisms required for sustaining a healthy feto-placental barrier and a healthy pregnancy such as activation of regulatory immune responses with a predominance of regulatory T cells lead to immune evasion and propagation of cancer...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29565619/cultural-processes-in-psychotherapy-for-perinatal-loss-breaking-the-cultural-taboo-against-perinatal-grief
#12
Rayna D Markin, Sigal Zilcha-Mano
This paper argues that there is a cultural taboo against the public recognition and expression of perinatal grief that hinders parents' ability to mourn and their psychological adjustment following a loss. It is proposed that this cultural taboo is recreated within the therapy relationship, as feelings of grief over a perinatal loss are minimized or avoided by the therapist and parent or patient. Importantly, it is suggested that if these cultural dynamics are recognized within the therapy relationship, then psychotherapy has the immense opportunity to break the taboo by validating the parent's loss as real and helping the parent to mourn within an empathic and affect-regulating relationship...
March 2018: Psychotherapy
https://www.readbyqxmd.com/read/29562949/the-developing-gut-microbiota-and-its-consequences-for-health
#13
M-J Butel, A-J Waligora-Dupriet, S Wydau-Dematteis
The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from the conception to the 2 years of life). The process of the gut microbiota establishment is included in this time window. Various perinatal determinants, such as cesarean section delivery, type of feeding, antibiotics treatment, gestational age or environment, can affect the pattern of bacterial colonization and result in dysbiosis. The alteration of the early bacterial gut pattern can persist over several months and may have long-lasting functional effects with an impact on disease risk later in life...
March 22, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29555564/neurogenesis-in-the-postnatal-cerebellum-after-injury
#14
REVIEW
Julia P Andreotti, Pedro H D M Prazeres, Luiz A V Magno, Marco A Romano-Silva, Akiva Mintz, Alexander Birbrair
The cerebellum plays major role in motor coordination and learning. It contains half of the neurons in the brain. Thus, deciphering the mechanisms by which cerebellar neurons are generated is essential to understand the cerebellar functions and the pathologies associated with it. In a recent study, Wojcinski et al. (2017) by using in vivo Cre/loxP technologies reveal that Nestin-expressing progenitors repopulated the external granular cell layer after injury. Depletion of postnatal external granular cell layer is not sufficient to induce motor behavior defects in adults, as the cerebellum recovers these neurons...
March 16, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29546926/-perinatal-dengue-a-case-report
#15
Ramiro Manzano Núñez, James Alejandro Zapata, Herney A García-Perdomo, Diego A Gomez, Mónica A Solís Velasco
INTRODUCTION: Few reports are available about perinatal dengue, with controversial results in regards the risk of perinatal outcome. OBJECTIVE: To report a case of perinatal dengue as a differential diagno sis with neonatal sepsis, which must be considered in endemic areas. CLINICAL CASE: Male newborn of a 23 year-old female, who presented a Non-Structural Protein 1 (NS1) antigen positive to dengue at 36 weeks of gestation and negative anti-dengue antibodies...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29536649/hyperbaric-oxygenation-and-glucose-amino-acids-substitution-in-human-severe-placental-insufficiency
#16
Michael Tchirikov, Erich Saling, Gauri Bapayeva, Michael Bucher, Oliver Thews, Gregor Seliger
In the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to severe IUGR. The patient received daily hyperbaric oxygenation (HBO, 100% O2 ) with 1.4 atmospheres absolute for 50 min for 7 days. At 31+4  weeks' gestation, the patient gave birth spontaneously to a newborn weighing 1378 g, pH 7.33, APGAR score 4/6/intubation. In follow-up examinations at 5 years of age, the boy was doing well without any neurological disturbance or developmental delay...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29528677/perinatal-testosterone-contributes-to-mid-to-post-pubertal-sex-differences-in-risk-for-binge-eating-in-male-and-female-rats
#17
Kristen M Culbert, Elaine B Sinclair, Britny A Hildebrandt, Kelly L Klump, Cheryl L Sisk
Exposure to testosterone early in life may contribute to sex differences and pubertal changes in risk for eating pathology (i.e., females > males, after pubertal onset). Specifically, perinatal testosterone permanently alters brain structure/function and drives the masculinization of several sex-differentiated behaviors. However, the effects of perinatal testosterone are often not evident until puberty when increases in gonadal hormones activate the expression of sex typical behavior, including eating behaviors (e...
February 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29523380/outcome-of-children-born-after-pregnancy-denial
#18
M Simermann, S Rothenburger, B Auburtin, J-M Hascoët
INTRODUCTION: Denial of pregnancy remains a phenomenon little known to healthcare professionals. Yet its repercussions are far from negligible. The aim of this study was to assess whether denial of pregnancy has an impact on the infant's development. PATIENTS AND METHOD: This prospective study included 51 full-term infants born in Nancy Regional Maternity Hospital between 1 January 2009 and 30 June 2015. In this study, the development of the children was followed longitudinally...
March 7, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29511388/prom-and-labour-effects-on-urinary-metabolome-a-pilot-study
#19
Alessandra Meloni, Francesco Palmas, Luigi Barberini, Rossella Mereu, Sara Francesca Deiana, Maria Francesca Fais, Antonio Noto, Claudia Fattuoni, Michele Mussap, Antonio Ragusa, Angelica Dessì, Roberta Pintus, Vassilios Fanos, Gian Benedetto Melis
Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM) in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1), out of labour with PROM (Ph2), and during labour with PROM (Ph3)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29486851/placental-pathologic-changes-and-perinatal-outcomes-in-placenta-previa
#20
Eun Jung Jung, Hwa Jin Cho, Jung Mi Byun, Dae Hoon Jeong, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Young Nam Kim
INTRODUCTION: Placenta previa is a condition in which the placenta implants in the poorly vascularized lower uterine segment, which may result in inadequate uteroplacental perfusion, in turn, adversely affect the neonatal outcome. Abnormal placentation may also lead to severe postpartum hemorrhage as placenta separation proceeds. We aimed to evaluate the differences in placental histopathology and perinatal outcomes in pregnancies complicated with placenta previa and controls. METHOD: We undertook a retrospective case-control study of 93 pregnancies with placenta previa and 81 controls between 2011 and 2017...
March 2018: Placenta
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