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Adiponectin

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https://www.readbyqxmd.com/read/29054483/risk-and-associates-of-incident-hip-fracture-in-type-1-diabetes-the-fremantle-diabetes-study
#1
Emma J Hamilton, Wendy A Davis, David G Bruce, Timothy M E Davis
AIMS: To determine the relative risk of incident hip fracture in patients with type 1 diabetes and matched controls, to examine baseline associates of incident hip fracture in the patients with type 1 diabetes, and to compare hip fracture rates in age- and sex- matched patients with type 1 versus type 2 diabetes. METHODS: Longitudinal observational study of 121 adults with type 1 diabetes (mean±SD age 43.0±15.5 years, 59.5% male) and 484 age- and sex-matched adults without diabetes...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29054470/circulating-adiponectin-increases-in-obese-women-after-sleeve-gastrectomy-or-gastric-bypass-driving-beneficial-metabolic-changes-but%C3%A2-with-no-relationship-with-carotid-intima-media-thickness
#2
Jesús M Gómez-Martin, José A Balsa, Enrique Aracil, María Insenser, Pablo Priego, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND & AIMS: Obesity surgery induces beneficial effects in metabolic and cardiovascular parameters. Adiponectin increase might be associated with some of these changes. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: We studied 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) and 20 to sleeve gastrectomy (SG). Twenty control women matched for age and baseline metabolic profiles were also included...
October 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29053943/inflammation-status-of-healthy-young-men-initial-and-specific-responses-to-resistance-training
#3
Johanna K Ihalainen, Heikki Peltonen, Göran Paulsen, Juha P Ahtiainen, Ritva S Taipale, Mari Hämäläinen, Eeva Moilanen, Antti A Mero
PURPOSE: Our primary aim was to study the effects of a 4 wk preparatory resistance training (RT) period followed by 12 wks of two specific RT protocols (either hypertrophic-strength, HS, or strength-hypertrophy-power, SHP, training) on inflammation markers and the possible relationship of the changes in abdominal fat and lean mass to the changes in inflammation status. METHODS: A total of 82 healthy men were included in the study. Maximal concentric leg press strength (1RM), total body lean mass, total body and abdominal fat mass, circulating high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), monocyte chemoattractant protein 1 (MCP-1), and selected adipocytokines (resistin, adiponectin and leptin) concentrations were measured before (PRE) and after 4 (wk4) and 16 weeks (wk16) of RT...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29052745/role-of-fat-and-bone-biomarkers-in-the-relationship-between-ethnicity-and-bone-mineral-density-in-older-men
#4
Grace M F Chan, Tessa Riandini, Sheryl Hui Xian Ng, Su Yen Goh, Chuen Seng Tan, E Shyong Tai, Gustavo Duque, Alvin Choon-Meng Ng, Kavita Venkataraman
Osteoporosis is an important health issue for older adults, and has been relatively understudied in older men. This study aimed to examine ethnic differences in bone mineral density (BMD), and elucidate the role of bone turnover markers (BTMs), fat and fat biomarkers on these ethnic differences. BMD at the lumbar spine and femoral neck, marrow fat at femoral neck, visceral adipose tissue (VAT) and subcutaneous adipose tissue, bone and fat biomarkers were evaluated in 120 healthy men aged ≥ 60 years. Indians had higher BMD values compared to Chinese at the lumbar spine (β = 20...
October 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29052034/high-molecular-weight-adiponectin-levels-in-healthy-community-dwelling-elderly-japanese-volunteers-a-5-year-prospective-observational-study
#5
Hiromasa Otsuka, Mitsuru Yanai, Hiroki Kobayashi, Akira Haketa, Motohiko Hara, Kaoru Sugama, Kimitoshi Kato, Masayoshi Soma
BACKGROUND: Serum adiponectin levels are associated with frailty and cardiovascular diseases. Longitudinal changes in adiponectin levels might enhance our understanding of age-related conditions and diseases. AIMS: This prospective observational study aimed to: (1) elucidate age-related changes in high-molecular-weight (HMW) adiponectin levels; and (2) identify variables predictive of elevated HMW adiponectin levels and the association with well-known adiponectin single-nucleotide polymorphisms (SNPs) in healthy, elderly Japanese participants...
October 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29049270/adipokine-profile-in-patients-with-type-2-diabetes-depends-on-degree-of-obesity
#6
Joanna Kocot, Piotr Dziemidok, Małgorzata Kiełczykowska, Anna Hordyjewska, Grzegorz Szcześniak, Irena Musik
BACKGROUND The fast pace of life, promoting fast food consumption and low physical activity, has resulted in obesity and/or diabetes as being serious social problems. The aim of the present study was to evaluate concentrations of selected adipokines (leptin, adiponectin, resistin, and visfatin) and to assess the leptin/adiponectin ratio in plasma of type 2 diabetes (T2D) patients in relation to degree of obesity. MATERIAL AND METHODS The study comprised 92 T2D subjects divided into 4 groups according to BMI value - I (normal body weight), II (overweight), III (obesity), and IV (severe obesity) - and 20 healthy volunteers (control group)...
October 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29048484/adiponectin-suppression-of-late-inflammatory-mediator-hmgb1-induced-cytokine-expression-in-raw-264-macrophage-cells
#7
Mohamed Elfeky, Takeshi Yoneshiro, Yuko Okamatsu-Ogura, Kazuhiro Kimura
High mobility group protein B1 (HMGB1) is a late inflammatory mediator released from inflammatory cells when stimulated, resulting in exaggerating septic symptoms. We recently demonstrated that full-length adiponectin, a potent anti-inflammatory adipokine, inhibits lipopolysaccharide-induced HMGB1 release. However, the effects of adiponectin on HMGB1-induced exaggerating signals currently remain unknown. This study aimed to investigate the effects of adiponectin on the pro-inflammatory function of HMGB1 in RAW264 macrophage cells...
October 18, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29048406/disparity-in-fetal-growth-between-twin-and-singleton-gestation-the-role-of-adipokines
#8
R Zemet, Y Shulman, R Hemi, B Brandt, E Sivan, H Kanety, S Mazaki-Tovi
OBJECTIVE: Twin pregnancies are characterized by unique pattern of attenuated fetal weight gain during late gestation compared with singleton gestation. The mechanism(s) responsible for regulating twin growth has not yet elucidated. Leptin and adiponectin are two adipocytokines implicated in metabolism and energy balance of fetuses, newborns and adults. Moreover, these hormones have been suggested to play a role in fetal growth. The objective of the study was to determine cord blood adiponectin and leptin in twins and singletons, with and without growth impairment...
October 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29042814/attenuated-serum-adiponectin-levels-are-associated-with-disease-severity-in-patients-with-non-traumatic-osteonecrosis-of-the-femoral-head
#9
Yong-Bin Yue, Xin Liu, Biao-Fang Wei
OBJECTIVE: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients. PATIENTS AND METHODS: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#10
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29039145/adiponectin-circulating-levels-and-10-year-2002-2012-cardiovascular-disease-incidence-the-attica-study
#11
Ioannis Kyrou, Olga Tsantarlioti, Demosthenes B Panagiotakos, Constantine Tsigos, Ekavi Georgousopoulou, Christina Chrysohoou, Ioannis Skoumas, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos
PURPOSE: Adiponectin is an adipokine with anti-inflammatory and cardiovascular-protective properties. Existing epidemiological evidence is conflicting on the exact relationship between adiponectin and long-term cardiovascular disease (CVD) risk. Our aim was to prospectively assess whether circulating adiponectin is associated with long-term incident CVD. METHODS: A population-based, prospective study in adults (>18 years) without previous CVD history (ATTICA study)...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29038028/adiponectin-and-sporadic-alzheimer-s-disease-clinical-and-molecular-links
#12
REVIEW
Liliana Letra, Tiago Rodrigues, Paulo Matafome, Isabel Santana, Raquel Seiça
Obesity has been consistently associated with Alzheimer's disease (AD) though the exact mechanisms by which it influences cognition are still elusive and subject of current research. Adiponectin, the most abundant adipokine in circulation, is inversely correlated with adipose tissue dysfunction and seems to be a central player in this association. In fact, different signalling pathways are shared by adiponectin and proteins involved in AD pathophysiology and considerable amount of evidence supports its direct and indirect influence on β-amyloid and tau aggregates formation...
October 13, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29037210/a-vicious-circle-between-insulin-resistance-and-inflammation-in-nonalcoholic-fatty-liver-disease
#13
REVIEW
Zhonge Chen, Rong Yu, Ying Xiong, Fangteng Du, Shuishan Zhu
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma. Lipotoxicity, insulin resistance (IR) and inflammation are involved in the disease process. Lipotoxicity promotes inflammation and IR, which in turn, increase adipocyte lipolysis and exacerbates lipotoxicity. Furthermore, IR and inflammation form a vicious circle, with each condition promoting the other and accelerating the development of NAFLD in the presence of lipotoxicity...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29036907/a-functional-interplay-between-igf-1-and-adiponectin
#14
REVIEW
Stefania Orrù, Ersilia Nigro, Annalisa Mandola, Andreina Alfieri, Pasqualina Buono, Aurora Daniele, Annamaria Mancini, Esther Imperlini
A functional relationship is suggested between two well-known protein hormones, insulin-like growth factor 1 (IGF-1) and adiponectin. In the last two decades in fact, different experimental evidence has indicated a non-random link between them. Here, we describe briefly the IGF-1 and adiponectin systems, and we then focus on their putative interplay in relation to several pathological conditions, including obesity, diabetes, insulin resistance, cardiovascular disease, and cancer. Although the existing studies are hardly comparable, they definitely indicate a functional connection between these two protein hormones...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035384/effect-of-anthelmintic-treatment-on-leptin-adiponectin-and-leptin-to-adiponectin-ratio-a-randomized-controlled-trial
#15
D L Tahapary, K de Ruiter, I Martin, E A T Brienen, L van Lieshout, Y Djuardi, C C Djimandjaja, J J Houwing-Duistermaat, P Soewondo, E Sartono, T Supali, J W A Smit, M Yazdanbakhsh
Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1...
October 16, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29033896/the-influence-of-a-kdt501-a-novel-isohumulone-on-adipocyte-function-in-humans
#16
Brian S Finlin, Beibei Zhu, Bernard P Kok, Cristina Godio, Philip M Westgate, Neile Grayson, Robert Sims, Jeffrey S Bland, Enrique Saez, Philip A Kern
OBJECTIVE: In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s). METHODS: Nine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29033577/are-adipocytokines-inflammatory-or-metabolic-mediators-in-patients-with-inflammatory-bowel-disease
#17
Resul Kahraman, Turan Calhan, Abdurrahman Sahin, Kamil Ozdil, Zuhal Caliskan, Elif Sinem Bireller, Bedia Cakmakoglu
This study examined the adiponectin and leptin levels and insulin resistance (IR) in patients with inflammatory bowel disease (IBD) and the associations between these factors and IBD characteristics. Fasting serum leptin, adiponectin, glucose, and insulin levels, as well as inflammatory parameters, were measured in 105 patients with IBD (49 patients with Crohn's disease [CD], 56 patients with ulcerative colitis [UC]) and 98 healthy controls [HC]. IR was evaluated using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#18
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29030734/erratum-to-inhibition-of-angiotensin-ii-induced-cardiac-fibrosis-by-atorvastatin-in-adiponectin-knockout-mice
#19
Sun Young Choi, Jong Sung Park, Mee Sook Roh, Chong-Rak Kim, Moo Hyun Kim, Victor Serebruany
In the original published article, Victor Serebruany was designated as the corresponding author in error. The corresponding author is Jong Sung Park. Dr. Park can be reached by email at thinkmed@dau.ac.kr.
October 13, 2017: Lipids
https://www.readbyqxmd.com/read/29030472/erratum-for-salma-et-al-tfe3-and-tfeb-transcriptionally-regulate-peroxisome-proliferator-activated-receptor-%C3%AE-2-expression-in-adipocytes-and-mediate-adiponectin-and-glucose-levels-in-mice
#20
Nunciada Salma, Jun S Song, Akinori Kawakami, Suprabha P Devi, Mehdi Khaled, José M Cacicedo, David E Fisher
No abstract text is available yet for this article.
November 1, 2017: Molecular and Cellular Biology
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