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https://www.readbyqxmd.com/read/29927399/-cerebral-atherosclerosis-a-biomarker-profile
#1
M M Tanashyan, O V Lagoda, A N Evdokimenko, A A Shabalina, A A Raskurazhev
AIM: To assess the changes in several biomarkers in patients with atherosclerosis of brachiocephalic arteries and shape a biomarker profile of cerebral atherosclerosis as an integrative index. MATERIAL AND METHODS: The study included 124 patients with atherosclerotic lesions of internal carotid arteries (82 men and 42 women) aged from 37 to 73 years. The patients were stratified by history of prior stroke into 'asymptomatic' and 'symptomatic'. Along with general clinical and neurological examinations, ultrasound analysis of brachiocephalic arteries, neuroimaging, identification of biomarkers reflecting different stages of atherogenesis and evaluation of pathomorphological parameters of atherosclerotic plaques removed during carotid endarterectomy surgery were performed...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29926073/-research-advances-in-the-regulation-of-cardiovascular-metabolic-disorders-and-its-related-risk-factors-by-c1q-tnf-related-proteins
#2
Shi-Han Zhang, Yun-Hui DU, Hai-Cun Yu, Yu-Ming Li, Hui-Rong Liu
The complement C1q/TNF related protein (CTRP) family is rapidly growing and currently comprises 15 members. Although CTRP proteins share a common structure composed of four distinct domains: a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain, which is homologous to adiponectin, each CTRP has a unique tissue expression profile and varied function. In this review we focus on the biochemistry and pleiotropic functions of CTRPs as new molecular mediators regulating cardiovascular metabolic disorders and its related risk factors diseases...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29925443/effects-of-scfa-on-the-dna-methylation-pattern-of-adiponectin-and-resistin-in-high-fat-diet-induced-obese-male-mice
#3
Yuanyuan Lu, Chaonan Fan, Aimin Liang, Xiuqin Fan, Rui Wang, Ping Li, Kemin Qi
Specific adipokines, such as adiponectin and resistin, are secreted from adipose tissue and are associated with the development of obesity. Supplementation of dietary SCFA can prevent and reverse high-fat-diet (HFD)-induced obesity. However, it is not clear whether SCFA ameliorate abnormal expression of adiponectin and resistin in the obese state. The aim of this study was to investigate the effects of SCFA on adiponectin and resistin's expressions in diet-induced obese mice, as well as the potential mechanisms associated with DNA methylation...
June 21, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29924824/effect-of-adiposity-on-tissue-specific-adiponectin-secretion
#4
James Reneau, Matthew Goldblatt, Jon Gould, Tammy Kindel, Andrew Kastenmeier, Rana Higgins, L Rosemary Rengel, Katherine Schoyer, Roland James, Brittaney Obi, Andrea Moosreiner, Kay Nicholson, Daisy Sahoo, Srividya Kidambi
Circulating adiponectin levels are lower in individuals with increased BMI and central adiposity. However, they are paradoxically higher in those with peripheral adiposity. We hypothesized that adiponectin secretion from central and peripheral adipose tissue depots may be associated with adiposity levels and its distribution. A total of 55 subjects (69% women) undergoing elective abdominal surgery (mean age: 53 ± 13 years) were recruited. Health history, anthropometrics, and cardiovascular disease risk factor measurements were obtained...
2018: PloS One
https://www.readbyqxmd.com/read/29924631/effects-of-postweaning-calorie-restriction-on-accelerated-growth-and-adiponectin-in-nutritionally-programmed-microswine-offspring
#5
Elizabeth A DuPriest, Baoyu Lin, Philipp Kupfer, Kaiu Sekiguchi, Amruta Bhusari, Alexandra Quackenbush, Almir Celebic, Terry K Morgan, Jonathan Q Purnell, Susan Pound Bagby
Poor prenatal development followed by rapid childhood growth conveys greater cardiometabolic risk in later life. Microswine offspring exposed to perinatal maternal protein restriction (MPR; "low protein offspring", LPO) grow poorly in late-fetal/neonatal stages. After weaning to ad libitum (AL) diet, LPO-AL exhibit accelerated growth and fat deposition rates with low adiponectin mRNA despite low-normal body fat and small intra-abdominal adipocytes. We examined effects of caloric restriction (CR) on growth and metabolic status in LPO and normal protein offspring (NPO) randomized to AL or CR diets from weaning...
June 20, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29922227/maternal-circulating-placental-growth-factor-and-neonatal-metabolic-health-biomarkers-in-small-for-gestational-age-infants
#6
Hua He, Anne Monique Nuyt, Zhong-Cheng Luo, Francois Audibert, Lise Dubois, Shu-Qin Wei, Haim A Abenhaim, Emmanuel Bujold, Isabelle Marc, Pierre Julien, William D Fraser
Small for gestational age (SGA) infants are at increased risk of type 2 diabetes in adulthood. It is unknown whether any prenatal biomarkers are helpful for identifying SGA infants with altered metabolic health profile at birth or later life. In a nested study of 162 SGA (birth weight < 10th percentile) and 161 optimal birth weight (25th-75th percentiles) control infants in the 3D (design, develop and discover) birth cohort in Canada, we assessed whether maternal circulating placental growth factor (PlGF), a biomarker of placental function, is associated with metabolic health biomarkers in SGA infants...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29920546/antidiabetic-effect-of-euterpe-oleracea-mart-a%C3%A3-a%C3%A3-extract-and-exercise-training-on-high-fat-diet-and-streptozotocin-induced-diabetic-rats-a-positive-interaction
#7
Graziele Freitas de Bem, Cristiane Aguiar Costa, Izabelle Barcellos Santos, Viviane da Silva Cristino Cordeiro, Lenize Costa Reis Marins de Carvalho, Marcelo Augusto Vieira de Souza, Ricardo de Andrade Soares, Pergentino José da Cunha Sousa, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
A growing body of evidence suggests a protective role of polyphenols and exercise training on the disorders of type 2 diabetes mellitus (T2DM). We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks and a single dose of STZ (35 mg/kg i.p.). Control (C) and Diabetic (D) animals were subdivided into four groups each: Sedentary, Training, ASE Sedentary, and ASE Training...
2018: PloS One
https://www.readbyqxmd.com/read/29920475/alterations-in-the-liver-of-intrauterine-growth-retarded-piglets-may-predispose-to-development-of-insulin-resistance-and-obesity-in-later-life
#8
K Ferenc, P Pietrzak, M Wierzbicka, P Matyba, E Grzesiuk, Z Gajewski, R Zabielski
Intrauterine growth retardation (IUGR) leads to increased predisposition to metabolic syndrome in adult life but the mechanisms remain obscure. Considering a significant number of functional similarities, IUGR piglets appear to be a good model to study the development of this syndrome in humans. The aim of the present study was to investigate the ultrastructure and proteomic profile of the liver in IUGR pig neonates to discover early markers of predisposition to obesity and insulin resistance. In our study intestine and liver tissue samples were investigated in 7 day old IUGR and normal body weight (NBW) littermate piglets using histometry, mass spectrometry, in-tissue cytometry analysis and confocal microscopy...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29917063/sodium-intake-is-associated-with-endothelial-damage-biomarkers-and-metabolic-dysregulation
#9
Carmen Campino, Rene Baudrand, Carolina Valdivia, Cristian Carvajal, Andrea Vecchiola, Alejandra Tapia-Castillo, Alejandro Martínez-Aguayo, Hernán Garcia, Lorena García, Fidel Allende, Sandra Solari, Cristóbal Fuentes, Calos F Lagos, Maria Paulina Rojas, Doris Muñoz, Carlos Fardella
Background: Mounting evidence has associated high sodium intake with hypertension, cardiovascular disease and stroke. We investigated whether high sodium intake modulates the parameters of endothelial damage, inflammation and oxidative stress. Methods: We used a cross-sectional study design including 223 Chilean subjects (6.9-65.0 years old). We measured aldosterone, renin activity, cortisol, cortisone, adiponectin, leptin, hs-CRP, IL-6, TNF-alpha, PAI-1, metalloproteinase (MMP)-9 and MMP-2 activity and malondialdehyde (MDA)...
June 16, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29916530/mir%C3%A2-6835%C3%A2-3p-regulates-the-function-of-pancreatic-islet-cells-by-modulating-the-expression-of-adipor1
#10
Huimin Wang, Lei Jiang, Zhenfu Li, Wei Wang, Chuanji Hao
Effective drugs and strategies for treating type 2 diabetes mellitus (2‑DM) are urgently required. The aim of the present study was to elucidate the mechanism underlying microRNA (miR)‑6835‑3p regulation of adiponectin receptor 1 (AdipoR1) expression and the miR‑6835‑3p/AdipoR1 signaling pathway in pancreatic islet cells. In addition, the potential anti‑diabetes effect of miR‑6835‑3p on insulin secretion was investigated. Luciferase activity analysis was performed to evaluate how miR‑6835‑3p targets the 3'‑untranslated region of AdipoR1...
June 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29914579/associations-between-hypertension-and-the-peroxisome-proliferator-activated-receptor-%C3%AE-ppard-gene-rs7770619-c-t-polymorphism-in-a-korean-population
#11
Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Jayoung Shon, Jong Ho Lee
BACKGROUND: Oxidative stress is associated with the increased risk of hypertension (HTN). This cross-sectional study is aimed to identify the association between the peroxisome proliferator-activated receptor-δ (PPARD) polymorphism and plasma malondialdehyde (MDA), an oxidative stress marker which is related to HTN development, and to determine whether PPARD gene is a candidate gene for HTN. RESULTS: One thousand seven hundred ninety-three individuals with normal blood pressure (BP) and HTN were included in this cross-sectional study...
June 18, 2018: Human Genomics
https://www.readbyqxmd.com/read/29914129/obesity-related-metabolic-risk-in-sedentary-hispanic-adolescent-girls-with-normal-bmi
#12
Gert-Jan van der Heijden, Zhiyue J Wang, Zili D Chu, Morey Haymond, Pieter J J Sauer, Agneta L Sunehag
Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat &ge; 27%; n = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; n = 8)...
June 15, 2018: Children
https://www.readbyqxmd.com/read/29913483/the-associations-between-the-growth-hormone-insulin-like-growth-factor-1-axis-adiponectin-resistin-and-metabolic-profile-in-children-with-growth-hormone-deficiency-before-and-during-growth-hormone-treatment
#13
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Anna Majcher, Beata Pyrżak
This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29912982/discovery-of-a-novel-potent-peptide-agonist-to-adiponectin-receptor-1
#14
Sunghwan Kim, Younho Lee, Jun Woo Kim, Young-Jin Son, Min Jung Ma, Jee-Hyun Um, Nam Doo Kim, Sang Hyun Min, Dong Il Kim, Brian B Kim
Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin...
2018: PloS One
https://www.readbyqxmd.com/read/29912570/the-use-of-a-stem-and-leaf-aqueous-extract-of-cissus-quadrangularis-cqr-300-to-reduce-body-fat-and-other-components-of-metabolic-syndrome-in-overweight-participants
#15
Robert Nash, Boris Azantsa, Dieudonne Kuate, Harrinder Singh, Julius Oben
BACKGROUND: Previous work had shown the ability of an aqueous leaf and stem extract of Cissus quandrangularis (300 mg of CQR, CQR-300) to improve components of metabolic syndrome (MS) in overweight individuals. OBJECTIVE: This small pilot study aimed to confirm the efficacy of CQR-300 in reducing the percentage body fat measured using two different methods-bioelectrical impedance assay versus dual-energy X-ray absorptiometry (DEXA). DESIGN: The study was an 8-week double-blind, placebo-controlled pilot trial on 67 individuals who were requested by a dietary counselor to maintain their normal exercise and dietary routines...
June 18, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29910810/adaptive-regulation-of-osteopontin-production-by-dendritic-cells-through-the-bidirectional-interaction-with-mesenchymal-stromal-cells
#16
Sara Scutera, Valentina Salvi, Luisa Lorenzi, Giorgia Piersigilli, Silvia Lonardi, Daniela Alotto, Stefania Casarin, Carlotta Castagnoli, Erica Dander, Giovanna D'Amico, Silvano Sozzani, Tiziana Musso
Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopontin (OPN), a cytokine involved in homeostatic and pathophysiologic responses, is constitutively expressed by DCs and regulated in the DC/MSC cocultures depending on the activation state of MSCs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910627/performance-of-body-mass-index-and-percentage-of-body-fat-in-predicting-cardiometabolic-risk-factors-in-thai-adults
#17
Somlak Vanavanan, Pornpen Srisawasdi, Mana Rochanawutanon, Nalinee Kumproa, Khanat Kruthkul, Martin H Kroll
Background: Body mass index (BMI) and percentage of body fat (PBF) are used to measure obesity; however, their performance in identifying cardiometabolic risk in Southeast Asians is unclear. Generally, Asian women have higher PBF and lower BMI than do men and other ethnic populations. This study was conducted to address whether a discord exists between these measures in predicting obesity-related cardiometabolic risk in a Thai population and to test whether associations between the measures and risk factors for cardiovascular disease have a sex-specific inclination...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29908833/direct-actions-of-adiponectin-on-changes-in-reproductive-metabolic-and-anti-oxidative-enzymes-status-in-the-testis-of-adult-mice
#18
Mayank Choubey, Ashutosh Ranjan, Puran S Bora, Fátima Baltazar, Amitabh Krishna
Obesity is a major health problem that is linked to decreased sperm count. It is hypothesized that an obesity-associated reduction in adiponectin secretion may be responsible for impairment of spermatogenesis. Therefore, the aim of the study was to evaluate the direct role of adiponectin in spermatogenesis and steroid synthesis in adult mice. This study showed that adiponectin receptors (AdipoR1 and AdipoR2) were localized in Leydig cells and seminiferous tubules in the testis of adult mice. The result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (PCNA) and survival (Bcl2) and by suppressing cell apoptosis...
June 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29908753/abdominal-obesity-and-insulin-resistance-after-an-episode-of-acute-pancreatitis
#19
Ruma G Singh, Sayali A Pendharkar, Aya Cervantes, Jaelim Cho, Victor Miranda-Soberanis, Maxim S Petrov
BACKGROUND: Emerging evidence indicates that individuals after an episode of acute pancreatitis (AP) are at an increased risk of developing metabolic derangements. While the link between general obesity and insulin resistance (IR) is well established, only a few studies have investigated the association between abdominal obesity and IR. The aim of this study was to investigate the associations between abdominal obesity and several indices of IR in individuals after an episode of AP. METHODS: Patients were eligible for this cross-sectional study if they were previously admitted with a primary diagnosis of AP based on the recent international guidelines...
May 1, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29907930/characterization-of-a-diet-induced-obesity-rat-model-for-periodontal-research
#20
Anna Damanaki, Marjan Nokhbehsaim, Kanishka Hiththetiya, Svenja Memmert, Jinlong Gao, Ky-Anh Nguyen, Werner Götz, Andreas Jäger, Gerhard Wahl, James Deschner
OBJECTIVES: Obesity is associated with periodontitis, but the mechanisms underlying this association have yet to be unraveled. The present investigation was to evaluate a common rat model, in which obesity is induced by high-fat, high-sucrose diet (HFSD), for its applicability in periodontal research. MATERIALS AND METHODS: Ten male Wistar rats were fed a 3-month HFSD along with a matching control group. Afterwards, the body weight, adipocyte morphology, leptin and adiponectin levels in adipose tissue, gingiva, and serum as well as the serum levels of triglyceride, cholesterol, and glucose were analyzed...
June 16, 2018: Clinical Oral Investigations
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