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https://www.readbyqxmd.com/read/28227390/bio-heat-transfer-model-of-electroconvulsive-therapy-effect-of-biological-properties-on-induced-temperature-variation
#1
Marilia M de Oliveira, Paul Wen, Tony Ahfock, Marilia M de Oliveira, Paul Wen, Tony Ahfock, Paul Wen, Marilia M de Oliveira, Tony Ahfock
A realistic human head model consisting of six tissue layers was modelled to investigate the behavior of temperature profile and magnitude when applying electroconvulsive therapy stimulation and different biological properties. The thermo-electrical model was constructed with the use of bio-heat transfer equation and Laplace equation. Three different electrode montages were analyzed as well as the influence of blood perfusion, metabolic heat and electric and thermal conductivity in the scalp. Also, the effect of including the fat layer was investigated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221305/a-novel-missense-variant-in-the-agrn-gene-congenital-myasthenic-syndrome-presenting-with-head-drop
#2
Mert Karakaya, Ozge Ceyhan-Birsoy, Alan H Beggs, Haluk Topaloglu
Congenital myasthenic syndromes (CMS) are a heterogeneous group of diseases of the neuromuscular junction caused by compromised synaptic transmission. Clinical features include early-onset weakness of limbs and oculobulbar muscles resulting in hypotonia, bulbar paresis, ptosis, and hypoventilation. The first dropped head syndrome in children were detected in 2 patients with LMNA and SEPN1 mutations. We report a 17-month-old boy with dropped head and limb-girdle weakness, who had no ptosis or ophthalmoplegia at presentation...
March 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28206871/swallowing-therapy-and-progressive-resistance-training-in-head-and-neck-cancer-patients-undergoing-radiotherapy-treatment-randomized-control-trial-protocol-and-preliminary-data
#3
Sara F Hajdú, Irene Wessel, Christoffer Johansen, Claus A Kristensen, Zahra T Kadkhoda, Christina C Plaschke, Susanne O Dalton
BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT) during radiotherapy...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28204987/the-effects-of-topical-carbonic-anhydrase-inhibitor-in-treatment-of-nystagmus
#4
Ebru Demet Aygit, Osman Bulut Ocak, Aslı İnal, Korhan Fazıl, Serpil Akar, Birsen Gokyigit
OBJECTIVE: To evaluate the effects of topical carbonic anhydrase inhibitor (CAI), brinzolamide (Azopt), for treatment of nystagmus patients. MATERIALS AND METHODS: Patients who used Brinzolamide for treatment of nystagmus were retrospectively analyzed. 23 patients were included in this study. The patients' diagnosis were idiopathic infantile nystagmus 18 (78.2%) and oculocutaneous albinism in 5 (21.8%). Azopt eye drop was used in both eyes, 3 times a day. Detailed eye examination in all of the patients before treatment and repeated at the end of the first week after treatment...
February 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28196288/clinical-adequacy-assessment-of-auto-contours-for-prostate-imrt-with-meaningful-endpoints
#5
Hamidreza Nourzadeh, William T Watkins, Mahmoud Ahmad, Cheukkai Hui, David Schlesinger, Jeffrey V Siebers
PURPOSE: To determine if radiation treatment plans created based on auto-segmented (AS) regions-of-interest (ROI)s are clinically equivalent to plans created based on manually segmented ROIs, where equivalence is evaluated using probabilistic dosimetric metrics and probabilistic biological endpoints for prostate IMRT. METHOD AND MATERIALS: Manually drawn contours and auto-segmented ROIs were created for 167 CT image sets acquired from 19 prostate patients. Auto-segmentation was performed utilizing Pinnacle's Smart Probabilistic Image Contouring Engine...
February 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28184025/metabolic-interrogation-as-a-tool-to-optimize-chemotherapeutic-regimens
#6
Vlad C Sandulache, Yunyun Chen, Lei Feng, William N William, Heath D Skinner, Jeffrey N Myers, Raymond E Meyn, Jinzhong Li, Ainiwaer Mijiti, James A Bankson, Clifton D Fuller, Marina Y Konopleva, Stephen Y Lai
Platinum-based (Pt) chemotherapy is broadly utilized in the treatment of cancer. Development of more effective, personalized treatment strategies require identification of novel biomarkers of treatment response. Since Pt compounds are inactivated through cellular metabolic activity, we hypothesized that metabolic interrogation can predict the effectiveness of Pt chemotherapy in a pre-clinical model of head and neck squamous cell carcinoma (HNSCC).We tested the effects of cisplatin (CDDP) and carboplatin (CBP) on DNA damage, activation of cellular death cascades and tumor cell metabolism, specifically lactate production...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28183865/compass-cues-used-by-a-nocturnal-bull-ant-myrmecia-midas
#7
Cody A Freas, Ajay Narendra, Ken Cheng
Ants use both terrestrial landmarks and cues derived from path integration to navigate to and from their nest location. These cues persist even as light levels drop during the twilight/night. Here we determined the compass cues used by a nocturnal bull ant, Myrmecia midas, in which the majority of the individuals begin foraging during the evening twilight period. Foragers of M. midas with vectors of≤5 m when displaced to unfamiliar locations did not follow the home vector, but instead showed random heading directions...
February 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28183050/deep-peroneal-nerve-palsy-due-to-osteochondroma-arising-from-fibular-head-and-proximal-lateral-tibia
#8
Murat Demiroğlu, Korhan Özkan, Bulent Kılıç, Akif Akçal, Mesut Akkaya, Feyza Ünlü Özkan
Following median and ulnar nerves, peroneal nerve entrapment is the most frequent nerve involvement in the body Katirji and Wilbourn (1998) [1]. Osteochondromas are the most common benign bone tumors comprising 9% of all bone tumors and 35% of benign bone tumors Porter (2000) [2]. Hereditary exostoses (HME) is an autosomal dominant disorder with variable penetrance characterized by multiple osteochondromas near joints. It is one of the most commonskeletal dysplasias with a frequency of about 1.18%. In this study, we aimed to present a case with a drop foot resulting from osteochondromas of proximal tibia and fibula and help to guide the clinicians in differential diagnosis according to SCARE criteria Agha (2016) [3]...
January 24, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28182762/longitudinal-change-of-selected-human-milk-oligosaccharides-and-association-to-infants-growth-an-observatory-single-center-longitudinal-cohort-study
#9
Norbert Sprenger, Le Ye Lee, Carlos Antonio De Castro, Philippe Steenhout, Sagar K Thakkar
BACKGROUND: Human milk is the recommended and sole nutrient source for newborns. One of the largest components of human milk is oligosaccharides (HMOs) with major constituents determined by the mother genotype for the fucosyltransferase 2 (FUT2, secretor) gene. HMO variation has been related with infant microbiota establishment, diarrhea incidence, morbidity and mortality, IgE associated eczema and body composition. OBJECTIVES: We investigated the (i) dependence of several major representative HMOs on the FUT2 status assessed through breast milk 2'Fucosyllactose (2'FL) and (ii) the relation of the 2'FL status with infant growth up to 4 months of life...
2017: PloS One
https://www.readbyqxmd.com/read/28167867/hip-resurfacing-international-perspectives-review-article
#10
REVIEW
Julien Girard
BACKGROUND: The hip resurfacing concept was developed for young and active patients, especially for femoral bone stock preservation. However, concerns about metal-on-metal bearings with adverse reactions to metal debris have led to a drop off in hip-resurfacing procedures. QUESTIONS/PURPOSES: The goal of this review is to evaluate our current knowledge of survivorship of second-generation hip resurfacing devices and elaborate international perspectives for product improvement...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28164149/single-low-dose-lipopolysaccharide-preconditioning-neuroprotective-against-axonal-injury-and-modulates-glial-cells
#11
Ryan C Turner, Zachary J Naser, Brandon P Lucke-Wold, Aric F Logsdon, Reyna L Vangilder, Rae R Matsumoto, Jason D Huber, Charles L Rosen
AIM: Over 7 million traumatic brain injuries (TBI) are reported each year in the United States. However, treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly understood. Lipopolysaccharide (LPS) administration before controlled cortical impact can contribute to neuroprotection. However, the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains unclear. METHODS: The authors hypothesized that preconditioning with a low dose of LPS (0...
January 2017: Neuroimmunology and Neuroinflammation
https://www.readbyqxmd.com/read/28127672/the-effect-on-snoring-of-using-a-pillow-to-change-the-head-position
#12
Dorotheea Cazan, Uwe Mehrmann, Angela Wenzel, Joachim T Maurer
PURPOSE: Although not a disease, primary snoring often leads to social problems. In an earlier retrospective pilot study, we found hints that individuals were snoring less in a lateral versus a supine head position. The aim of this study is to elucidate on the effect of an anti-snoring pillow which changes the head position. METHODS: We designed an interventional, controlled, and randomized crossover study. It included 22 participants, between 18 and 78 years, who snored, had a BMI ≤ 30, and a sleep partner...
January 27, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28123336/narcolepsy-and-cataplexy-a-pediatric-case-report
#13
Tülin Savaş, Ilknur Erol, Semra Saygı, Mehmet Ali Habeşoğlu
Narcolepsy is characterized by excessive sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis during the rapid eye movement period of sleep. Herein, we present a boy aged eight years who was diagnosed as having narcolepsy and cataplexy about thirteen months after his first presentation. He was admitted with symptoms of daytime sleepiness. In the follow-up, cataplexy in the form of head dropping attacks developed seven months after the first admission. The patient was investigated for different prediagnoses and was eventually diagnosed as having narcolepsy and cataplexy through polysomnography and multiple sleep latency tests thirteen months after the first presentation...
December 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28120788/a-practical-approach-to-the-patient-presenting-with-dropped-head
#14
Marija Cauchi, Eleanor Marsh
Head drop, or having a dropped head, is an uncommon condition in which patients present with a disabling inability to lift their head. It may arise in many neurological conditions that can be divided into those with neuromuscular weakness of neck extensors and those with increased tone of neck flexors. The most common neuromuscular causes include myasthenia gravis, motor neurone disease and myositis, while neck dystonia secondary to movement disorders can cause an increased tone. Investigations should include blood tests, imaging, muscle biopsy and neurophysiological studies...
December 2016: Practical Neurology
https://www.readbyqxmd.com/read/28090780/a-multi-body-dynamics-study-on-a-weight-drop-test-of-rat-brain-injury
#15
Wenyi Yan, Germain Sossou, Ramesh Rajan
Traumatic brain injury (TBI), induced by impact of an object with the head, is a major health problem worldwide. Rats are a well-established animal analogue for study of TBI and the weight-drop impact-acceleration (WDIA) method is a well-established model in rats for creating diffuse TBI, the most common form of TBI seen in humans. However, little is known of the biomechanics of the WDIA method and, to address this, we have developed a four-degrees-of-freedom multi-body mass-spring-damper model for the WDIA test in rats...
January 16, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28086988/computed-tomographic-findings-and-treatment-of-a-bull-with-pituitary-gland-abscess
#16
Ueli Braun, Alexandra Malbon, Manon Kochan, Barbara Riond, Fredi Janett, Cornelia Iten, Matthias Dennler
BACKGROUND: In cattle, the prognosis of brain abscess is unfavourable and treatment is therefore not recommended. To the knowledge of the authors, there has been no report of successful treatment of a brain abscess in cattle.This report describes the clinical, computed tomographic and postmortem findings in a Holstein-Friesian bull with a hypophyseal abscess. CASE REPORT: The main clinical findings were generalised ataxia, ptyalism, prolapse of the tongue, dropped jaw, dysphagia, head tilt and unilateral ptosis...
January 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28078065/clinical-features-of-neuromuscular-disorders-in-patients-with-n-type-voltage-gated-calcium-channel-antibodies
#17
Andreas Totzeck, Petra Mummel, Oliver Kastrup, Tim Hagenacker
Neuromuscular junction disorders affect the pre- or postsynaptic nerve to muscle transmission due to autoimmune antibodies. Members of the group like myasthenia gravis and Lambert-Eaton syndrome have pathophysiologically distinct characteristics. However, in practice, distinction may be difficult. We present a series of three patients with a myasthenic syndrome, dropped-head syndrome, bulbar and respiratory muscle weakness and positive testing for anti-N-type voltage-gated calcium channel antibodies. In two cases anti-acetylcholin receptor antibodies were elevated, anti-P/Q-type voltage-gated calcium channel antibodies were negative...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28069503/wettability-gradient-on-the-elytra-in-the-aquatic-beetle-cybister-chinensis-and-its-role-in-angular-position-of-the-beetle-at-water-air-interface
#18
Mingxia Sun, Yuan Chen, Yongmei Zheng, Mingming Zhen, Chunying Shu, Zhendong Dai, Aiping Liang, Stanislav N Gorb
: The surface of the elytra in some species of aquatic beetles displays relatively low contact angles (CAs), even showing hydrophilic properties. In this study, we report on an observation that both sexes of Cybister chinensis beetle fresh elytral surface do not exhibit uniform CA, but rather a wettability gradient along the longitudinal axis in posterior direction. The wettability is very different between females and males due to the presence (female) or absence (male) of channels on the elytral surface...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28068376/an-objective-functional-characterisation-of-head-movement-impairment-in-individuals-with-neck-muscle-weakness-due-to-amyotrophic-lateral-sclerosis
#19
Silvia Pancani, Wendy Tindale, Pamela J Shaw, Christopher J McDermott, Claudia Mazzà
BACKGROUND: Neck muscle weakness and head drop are well recognised in patients with Amyotrophic lateral sclerosis (ALS), but an objective characterisation of the consequent head movement impairment is lacking. The aim of this study was to quantitatively characterise head movements in ALS compared to aged matched controls. METHODS: We evaluated two groups, one of thirteen patients with ALS and one of thirteen age-matched controls, during the execution of a series of controlled head movements, performed while wearing two inertial sensors attached on the forehead and sternum, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28062122/airflow-behavior-changes-in-upper-airway-caused-by-different-head-and-neck-positions-comparison-by-computational-fluid-dynamics
#20
Wei Wei, Shi-Wei Huang, Lian-Hua Chen, Yang Qi, Yi-Min Qiu, Shi-Tong Li
The feasibility of computational fluid dynamics (CFD) to evaluate airflow characteristics in different head and neck positions has not been established. This study compared the changes in volume and airflow behavior of the upper airway by CFD simulation to predict the influence of anatomical and physiological airway changes due to different head-neck positions on mechanical ventilation. One awake volunteer with no risk of difficult airway underwent computed tomography in neutral position, extension position (both head and neck extended), and sniffing position (head extended and neck flexed)...
December 29, 2016: Journal of Biomechanics
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