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Inhaler nebulizer

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https://www.readbyqxmd.com/read/28075194/aerosol-drug-delivery-during-noninvasive-positive-pressure-ventilation-effects-of-intersubject-variability-and-excipient-enhanced-growth
#1
Ross L Walenga, P Worth Longest, Anubhav Kaviratna, Michael Hindle
BACKGROUND: Nebulized aerosol drug delivery during the administration of noninvasive positive pressure ventilation (NPPV) is commonly implemented. While studies have shown improved patient outcomes for this therapeutic approach, aerosol delivery efficiency is reported to be low with high variability in lung-deposited dose. Excipient enhanced growth (EEG) aerosol delivery is a newly proposed technique that may improve drug delivery efficiency and reduce intersubject aerosol delivery variability when coupled with NPPV...
January 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28073994/vibrating-mesh-nebulizer-compared-with-metered-dose-inhaler-in-mechanically-ventilated-subjects
#2
Meagan N Dubosky, Yi-Fan Chen, Mary E Henriksen, David L Vines
BACKGROUND: The impact of various aerosol delivery devices on patient outcomes during mechanical ventilation is unknown. If one method of delivery results in a higher ventilator-associated pneumonia (VAP) rate than another, multiple patient outcomes may be affected. This study aimed to determine whether there was a difference in VAP occurrence and patient outcomes (days receiving ventilation and in-hospital mortality) between the vibrating mesh nebulizer (AeroNeb Solo) and the metered-dose inhaler (MDI)...
January 10, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28028601/voluntary-inhalation-of-methamphetamine-a-novel-strategy-for-studying-intake-non-invasively
#3
C Juarez-Portilla, R D Kim, M Robotham, M Tariq, M Pitter, J LeSauter, R Silver
RATIONALE: The abuse of the psychostimulant methamphetamine (MA) is associated with substantial costs and limited treatment options. To understand the mechanisms that lead to abuse, animal models of voluntary drug intake are crucial. OBJECTIVES: We aimed to develop a protocol to study long-term non-invasive voluntary intake of MA in mice. METHODS: Mice were maintained in their home cages and allowed daily 1 h access to an attached tunnel leading to a test chamber in which nebulized MA was available...
December 27, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/28018152/evaluation-of-medication-related-self-care-skills-in-patients-with-cystic-fibrosis
#4
Kelsey Lackey Lewis, Barnabas John, Michelle Condren, Sandra M Carter
BACKGROUND: As the life expectancy of patients with cystic fibrosis (CF) increases, the focus on ensuring success with medication therapies is increasingly important. The ability of patients to autonomously manage medications and related therapies is poorly described in the literature. OBJECTIVE: The goal of this project was to assess the level of medication-related knowledge and self-care skills in patients with CF. METHODS: This project took place in a Cystic Fibrosis Foundation accredited affiliate center...
November 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28007545/platinum-pharmacokinetics-in-mice-following-inhalation-of-cisplatin-dry-powders-with-different-release-and-lung-retention-properties
#5
Vincent Levet, Romain Merlos, Rémi Rosière, Karim Amighi, Nathalie Wauthoz
Pharmacokinetics of cisplatin administered by the pulmonary route were established in mice using dry powders inhaler (DPI) formulations showing immediate (F1) and controlled release (CR, solid lipid microparticles) in vitro, without (F2) or with PEGylated excipients (F3, F4). Formulation administration was realized using dry powder blends (correspondingly named thereafter F1B to F4B) able to reproducibly deliver particles in vivo using a DP-4M Dry Powder Insufflator™. Their platinum pharmacokinetics were established over 48h in lungs, total blood and non-target organs vs...
December 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28003554/reliability-of-vibrating-mesh-technology
#6
Ashwin A Gowda, Ann D Cuccia, Gerald C Smaldone
BACKGROUND: For delivery of inhaled aerosols, vibrating mesh systems are more efficient than jet nebulizers are and do not require added gas flow. We assessed the reliability of a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd, Galway Ireland) suitable for use in mechanical ventilation. METHODS: An initial observational study was performed with 6 nebulizers to determine run time and efficiency using normal saline and distilled water. Nebulizers were run until cessation of aerosol production was noted, with residual volume and run time recorded...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/27999750/reprogramming-the-lung-microenvironment-by-inhaled-immunotherapy-fosters-immune-destruction-of-tumor
#7
Valentino Le Noci, Michele Sommariva, Monica Tortoreto, Nadia Zaffaroni, Manuela Campiglio, Elda Tagliabue, Andrea Balsari, Lucia Sfondrini
Due to their constant exposure to inhaled antigens, lungs represent a particularly immunosuppressive environment that limits excessive immune responses; however, cancer cells can exploit this unique environment for their growth. We previously described the ability of aerosolized CpG-ODN combined with Poly(I:C) (TLR9 and TLR3 agonists, respectively) to promote antitumor immunity in a B16 melanoma lung metastasis model. Here, we explored the possibility of improving the therapeutic efficacy of TLR9/TLR3 agonist combinations by including in the inhalant either an antibody directed to both Ly6G and Ly6C markers to locally deplete myeloid-derived suppressive cells (MDSCs) or IFNα to directly activate the natural killer (NK) and macrophage innate immune cells in the lung...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27999047/efficacy-and-pharmacokinetics-of-me1100-a-novel-optimized-formulation-of-arbekacin-for-inhalation-compared-with-amikacin-in-a-murine-model-of-ventilator-associated-pneumonia-caused-by-pseudomonas-aeruginosa
#8
Norihito Kaku, Yoshitomo Morinaga, Kazuaki Takeda, Kosuke Kosai, Naoki Uno, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
BACKGROUND: Arbekacin is an aminoglycoside that shows strong antimicrobial activity against Gram-positive bacteria, including MRSA, as well as Pseudomonas aeruginosa The therapeutic effectiveness of arbekacin is directly related to Cmax at the infection site. To maximize drug delivery to the respiratory tract and minimize the systemic toxicity, arbekacin optimized for inhalation, ME1100, is under development. In this study, we investigated the efficacy and pharmacokinetics of ME1100 in a murine model of ventilator-associated pneumonia caused by P...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27979766/nebulized-solid-lipid-nanoparticles-for-the-potential-treatment-of-pulmonary-hypertension-via-targeted-delivery-of-phosphodiesterase-5-inhibitor
#9
Shaimaa Makled, Noha Nafee, Nabila Boraie
Phosphodiesterase type 5 (PDE-5) inhibitors - among which sildenafil citrate (SC) - play a primary role in the treatment of pulmonary hypertension (PH). Yet, SC can be only administered orally or parenterally with lot of risks. Targeted delivery of SC to the lungs via inhalation/nebulization is mandatory. In this study, solid lipid nanoparticles (SLNs) loaded with SC were prepared and characterized in terms of colloidal, morphological and thermal properties. The amount of drug loaded and its release behavior were estimated as a function of formulation variables...
December 12, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27977321/comparative-study-on-the-size-distributions-respiratory-deposition-and-transport-of-particles-generated-from-commonly-used-medical-nebulizers
#10
Yang Wang, Jiayu Li, Anna Leavey, Caroline O'Neil, Hilary M Babcock, Pratim Biswas
BACKGROUND: Medical nebulizers are widely and conveniently used to deliver medication to the lungs as an inhalable mist; however, the deposition of nebulized particles in the human respiratory system and the transport of the nebulized particles in the environment have not been studied in detail. METHODS: Five medical nebulizers of three different types (constant output, breath enhanced, and dosimetric) were evaluated. The size distribution functions (SDFs) and respiratory deposition of the particles generated from the nebulizers were characterized...
December 15, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27977306/nasal-and-olfactory-deposition-with-normal-and-bidirectional-intranasal-delivery-techniques-in-vitro-tests-and-numerical-simulations
#11
Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zhou
BACKGROUND: Intranasal delivery protocols that can effectively deposit drugs to the olfactory region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition on a regional or local basis, which is crucial in assessing the performance of targeted olfactory drug delivery. OBJECTIVES: To visually and quantitatively compare drug depositions in the nose and olfactory region with normal and bidirectional breathing patterns with vibrating mesh and jet nebulizers...
December 15, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27942208/three-minute-constant-rate-step-test-for-detecting-exertional-dyspnea-relief-after-bronchodilation-in-copd
#12
Benoit Borel, Courtney A Wilkinson-Maitland, Alan Hamilton, Jean Bourbeau, Hélène Perrault, Dennis Jensen, François Maltais
BACKGROUND: The aim of this study was to evaluate the responsiveness of the 3-minute constant rate step test (3-MST) to detect the relief of exertional dyspnea (respiratory discomfort) after acute bronchodilation in COPD patients. PATIENTS AND METHODS: A total of 40 patients with moderate-to-severe COPD (mean forced expiratory volume in 1 second: 45.7 (±14.7), % predicted) performed four 3-MSTs at randomly assigned stepping rates of 14, 16, 20 and 24 steps/min after inhalation of nebulized ipratropium bromide (500 µg)/salbutamol (2...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27942102/quality-of-acute-asthma-care-in-two-tertiary-hospitals-in-a-state-in-south-western-nigeria-a-report-of-clinical-audit
#13
Olufemi Olumuyiwa Desalu, Adekunle Olatayo Adeoti, Olarinde Jeffrey Ogunmola, Joseph Olusesan Fadare, Tolutope Fasanmi Kolawole
BACKGROUND: To audit the quality of acute asthma care in two tertiary hospitals in a state in the southwestern region of Nigeria and to compare the clinical practice against the recommendations of the Global Initiative for Asthma (GINA) guideline. PATIENTS AND METHODS: We carried out a retrospective analysis of 101 patients who presented with acute exacerbation of asthma to the hospital between November 2010 and October 2015. RESULTS: Majority of the cases were females (66...
November 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27928190/single-center-retrospective-evaluation-of-inhaled-corticosteroid-use-for-chronic-obstructive-pulmonary-disease-exacerbation-patients-receiving-systemic-corticosteroids
#14
Taylor Steuber, Dane Shiltz
Purpose: To determine the frequency of inappropriate inhaled corticosteroid (ICS) therapy when it is prescribed concurrently with systemic corticosteroids; to identify cost-savings potential in the setting of chronic obstructive pulmonary disease (COPD) exacerbations. Methods: Patients admitted to 1 of 8 hospital locations utilizing an integrated electronic health record within the health system for COPD exacerbations treated with systemic corticosteroids (equivalent to at least 30 mg of oral prednisone) between July 1, 2013 and June 30, 2014 were included in a retrospective chart review...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27888990/a-randomized-controlled-multicentric-study-of-inhaled-budesonide-and-intravenous-methylprednisolone-in-the-treatment-on-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#15
Zhen Ding, Xiu Li, Youjin Lu, Guangsheng Rong, Ruiqing Yang, Ruixia Zhang, Guiqin Wang, Xiqiang Wei, Yongqing Ye, Zhaoxia Qian, Hongyan Liu, Daifeng Zhu, Ruiqing Zhou, Kun Zhu, Rongping Ni, Kui Xia, Nan Luo, Cong Pei
BACKGROUND: Almost all international guidelines recommend corticosteroids for management of exacerbations of chronic obstructive pulmonary disease (COPD), because it leads to improved outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Nevertheless, due to its side effects, there are still concerns regarding the use of systemic corticosteroid (SC). Inhaled corticosteroids (IC) can be used as an alternative to SC, while reducing the risk of occurrence of side effects...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27884712/solid-lipid-nanoparticles-for-sustained-pulmonary-delivery-of-yuxingcao-essential-oil-preparation-characterization-and-in-vivo-evaluation
#16
Yun Zhao, Yue-Xing Chang, Xiao Hu, Chun-Yu Liu, Li-Hui Quan, Yong-Hong Liao
The objective of this study was to prepare solid lipid nanoparticles (SLNs) for sustained pulmonary delivery of Yuxingcao essential oil (YEO). Three YEO loaded SLNs (SLN-200, SLN-400 and SLN-800) with different particle size were prepared and separated following a high-shear homogenization technique using Compritol 888 ATO as lipid and polyvinyl alcohol as an emulsifier. The particle size, zeta potential, drug encapsulation efficiency and drug loading of the SLNs were determined to be between 171 and 812nm, -17...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27863863/effect-of-%C3%AE-2-adrenergic-receptor-stimulation-on-lung-fluid-in-stable-heart-failure-patients
#17
Bryan J Taylor, Eric M Snyder, Maile L Richert, Courtney M Wheatley, Steven C Chase, Lyle J Olson, Bruce D Johnson
BACKGROUND: The purpose of this study was to determine: (1) whether stable heart failure patients with reduced ejection fraction (HFrEF) have elevated extravascular lung water (EVLW) when compared with healthy control subjects; and (2) the effect of acute β2-adrenergic receptor (β2AR) agonist inhalation on lung fluid balance. METHODS: Twenty-two stable HFrEF patients and 18 age- and gender-matched healthy subjects were studied. Lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO), pulmonary capillary blood volume (Vc) (via re-breathe) and lung tissue volume (Vtis) (via computed tomography) were assessed before and within 30 minutes after administration of nebulized albuterol...
October 2, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27849432/monitoring-the-inhalation-flow-rate-of-nebulized-aerosols-using-an-ultrasonic-flow-meter-in-vitro-assessment
#18
Michael Y Yang, Hak-Kim Chan
BACKGROUND: The measurement of aerosol flow rates without obscuration of the flow is of particular concern with in vivo lung deposition studies, where precise knowledge of aerosol particle size distributions is a necessary requirement for the development of predictive correlations. This study examines the utility of an ultrasonic flow meter for such measurements and determines if a valved system can be attached to the flow meter for sampling exhaled aerosols. METHODS: The flow rate across a D-30 flow meter was compared with and without nebulization of 0...
November 16, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27848886/liposomes-for-pulmonary-drug-delivery-the-role-of-formulation-and-inhalation-device-design
#19
Abdelbary Elhissi
Liposomes are established drug carriers for inhalation owing to their safety and ability to provide controlled drug release in the lung. These carriers can entrap a wide range of therapeutic molecules for delivery in large volumes to the peripheral airways using medical nebulizers. Pressurized metered inhalers (pMDIs), soft mist inhalers (SMIs) and dry powder inhalers (DPIs) can deliver relatively small quantities of medication to the lung when compared to medical nebulizers which can deliver large volumes using simple liposome preparation techniques...
November 16, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27843842/evaluation-of-proficiency-in-using-different-inhaler-devices-among-intern-doctors
#20
Ravish M Kshatriya, Nimit V Khara, Rajiv P Paliwal, Satish N Patel
CONTEXT: Doctors may have deficiencies in the ability to use different inhalers, which in turn, can result in improper technique by the patients and poorly controlled asthma and chronic obstructive pulmonary disease (COPD). AIMS: To evaluate intern doctors' proficiency in using various inhaler devices. MATERIALS AND METHODS: Seventy interns were evaluated for their proficiency in using pressurized metered dose inhaler (pMDI), pMDI with spacer, rotahaler, turbuhaler, and nebulizer...
April 2016: Journal of Family Medicine and Primary Care
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