Suzan van Amerongen, Surya V Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D Cherry, Charles Bernick, Yonas E Geda, Jennifer V Wethe, Douglas I Katz, Michael L Alosco, Charles H Adler, Laura J Balcer, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H Daneshvar, Elizabeth A Colasurdo, Jeffrey J Iliff, Gail Li, Elaine R Peskind, Martha E Shenton, Eric M Reiman, Jeffrey L Cummings, Robert A Stern
BACKGROUND: Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of the neuropathological entity chronic traumatic encephalopathy (CTE). A core feature of TES is neurobehavioral dysregulation (NBD), a neuropsychiatric syndrome in repetitive head impact (RHI)-exposed individuals, characterized by a poor regulation of emotions/behavior. To discover biological correlates for NBD, we investigated the association between biomarkers of inflammation (interleukin (IL)-1β, IL-6, IL-8, IL-10, C-reactive protein (CRP), tumor necrosis factor (TNF)-α) in cerebrospinal fluid (CSF) and NBD symptoms in former American football players and unexposed individuals...
February 9, 2024: Journal of Neuroinflammation