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Bone marrow aspirate concentration

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https://www.readbyqxmd.com/read/28203511/a-retrospective-look-at-integrating-a-novel-regenerative-medicine-approach-in-plastic-limb-reconstruction
#1
Edgardo R Rodriguez Collazo, Christopher R Rathbone, Brian R Barnes
Full-thickness wounds that have rendered patients candidates for amputation may require techniques that may include a combinatorial approach above traditional standard of care. The purpose of this retrospective study was to evaluate the effectiveness of an innovative approach whereby several therapies were combined to avoid amputation. Patients with full-thickness wounds who were previously recommended for amputation and were treated with the combinatorial approach of muscle flap reconstruction and concentrated bone marrow aspirate, platelet-rich plasma, INTEGRA Wound matrix, vacuum-assisted closure, and split-thickness skin grafts were assessed retrospectively...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28187903/the-influence-of-trocar-fenestration-and-volume-on-connective-tissue-progenitor-cells-stem-cells-in-arthroscopic-bone-marrow-aspiration-from-the-proximal-humerus
#2
Andreas Voss, Mary Beth McCarthy, Hardeep Singh, Knut Beitzel, Jessica DiVenere, Mark P Cote, Alexander R Hoberman, Michael Nowak, Andreas B Imhoff, Augustus D Mazzocca
PURPOSE: To evaluate the number of connective tissue progenitor cells (CTPs) and nucleated cells obtained during bone marrow aspiration (BMA) from the proximal humerus using either a fenestrated or a nonfenestrated trocar and determine differences in varying amounts of aspiration volume. The first hypothesis was that the number of CTPs extracted with the fenestrated trocar would be greater due to its potential to extract more cells through its fenestrations. The second hypothesis was that using consecutive aspirations with either trocar would provide a consistent number of CTPs and nucleated cells throughout the aspiration with no significant decrease of cells at the end...
February 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28176272/effects-of-combined-raav-mediated-tgf-%C3%AE-and-sox9-gene-transfer-and-overexpression-on-the-metabolic-and-chondrogenic-activities-in-human-bone-marrow-aspirates
#3
Ke Tao, Ana Rey-Rico, Janina Frisch, Jagadeesh Kumar Venkatesan, Gertrud Schmitt, Henning Madry, Jianhao Lin, Magali Cucchiarini
BACKGROUND: Transplantation of genetically modified bone marrow concentrates is an attractive approach to conveniently activate the chondrogenic differentiation processes as a means to improve the intrinsic repair capacities of damaged articular cartilage. METHODS: Human bone marrow aspirates were co-transduced with recombinant adeno-associated virus (rAAV) vectors to overexpress the pleiotropic transformation growth factor beta (TGF-β) and the cartilage-specific transcription factor sox9 as a means to enhance the chondroreparative processes in conditions of specific lineage differentiation...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28170175/genetic-modification-of-human-peripheral-blood-aspirates-using-recombinant-adeno-associated-viral-vectors-for-articular-cartilage-repair-with-a-focus-on-chondrogenic-transforming-growth-factor-%C3%AE-gene-delivery
#4
Janina Frisch, Patrick Orth, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Dieter Kohn, Henning Madry, Magali Cucchiarini
Transplantation of genetically modified peripheral blood aspirates that carry chondrogenically competent progenitor cells may offer new, convenient tools to treat articular cartilage lesions compared with the more complex and invasive application of bone marrow concentrates or of bone marrow-derived mesenchymal stem cells. Here, we show that recombinant adeno-associated viral (rAAV) vectors are powerful gene vehicles capable of successfully targeting primary human peripheral blood aspirates in a stable and safe manner, allowing for an efficient and long-term transgene expression in such samples (up to 63 days with use of a lacZ reporter gene and for at least 21 days with application of the pleiotropic, chondrogenic factor transforming growth factor-β [TGF-β])...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28144574/current-management-of-talar-osteochondral-lesions
#5
REVIEW
Arianna L Gianakos, Youichi Yasui, Charles P Hannon, John G Kennedy
Osteochondral lesions of the talus (OLT) occur in up to 70% of acute ankle sprains and fractures. OLT have become increasingly recognized with the advancements in cartilage-sensitive diagnostic imaging modalities. Although OLT may be treated nonoperatively, a number of surgical techniques have been described for patients whom surgery is indicated. Traditionally, treatment of symptomatic OLT have included either reparative procedures, such as bone marrow stimulation (BMS), or replacement procedures, such as autologous osteochondral transplantation (AOT)...
January 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28141695/the-influence-of-aspiration-volume-on-the-number-of-osteoblastic-progenitors-obtained-from-bone-marrow-in-children
#6
Suzanne M Yandow, Samuel K Van de Velde, Jeanne Siebert, Sherrie L Perkins
BACKGROUND: Autologous bone marrow aspirates are utilized to treat various conditions in children. The biological value of bone marrow aspirate depends on the concentration of competent osteoblastic progenitors present in the aspirate. It has been shown in adults that increasing bone marrow aspiration volume beyond 2 mL decreases the concentration of osteoblast progenitor cells because of dilution of the sample with peripheral blood. The effect of varying bone marrow aspiration volumes on the osteoblast cell content has not been determined in children...
January 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28110392/tarsal-navicular-stress-fractures
#7
REVIEW
Rachel J Shakked, Emily E Walters, Martin J O'Malley
PURPOSE OF REVIEW: Navicular stress fractures are common in athletes and management is debated. This article will review the evaluation and management of navicular stress fractures. RECENT FINDINGS: Various operative and non-operative adjunctive treatment modalities are reviewed including the relevance of vitamin D levels, use of shock wave therapy and bone marrow aspirate concentrate (BMAC), and administration of teriparatide. Surgical treatment may be associated with earlier return to sports...
January 21, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28105983/effect-of-bone-marrow-aspirate-concentrate-platelet-rich-plasma-on-tendon-derived-stem-cells-and-rotator-cuff-tendon-tear
#8
Sun Jeong Kim, Da Hyun Song, Jong Wook Park, Silvia Park, Sang Jun Kim
Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon derived stem cells (TDSCs) but there has been no study about the effect of BMAC-PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC-PRP on the TDSCs and to find the therapeutic effect of BMAC-PRP on the rotator cuff tendon tear. Chondrogenic and osteogenic potential of TDSCs decreased, but adipogenic potential of TDSCs revealed no significant difference when they were co-cultured with BMAC-PRP...
January 20, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28018908/partial-cranial-cruciate-ligament-tears-treated-with-stem-cell-and-platelet-rich-plasma-combination-therapy-in-36-dogs-a-retrospective-study
#9
Sherman O Canapp, Christopher S Leasure, Catherine Cox, Victor Ibrahim, Brittany J Carr
OBJECTIVE: To evaluate outcomes in 36 dogs with a partial cranial cruciate ligament (CCL) tear treated with autologous bone marrow aspirate concentrate (BMAC) or adipose-derived progenitor cells (ADPC) with platelet-rich plasma (PRP) combination. MATERIALS AND METHODS: Medical records of client-owned dogs diagnosed with an early partial (≤50%) tear of the craniomedial band of the CCL that was treated with BMAC-PRP or ADPC-PRP were reviewed from 2010 to 2015. Signalment, medical history, physical and orthopedic examination, objective temporospatial gait analyses, radiographs, day 0 and day 90 diagnostic arthroscopy findings, treatment, and outcome were among the data collected...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28012152/erratum-to-bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#10
Jorge Chahla, Mark E Cinque, Jason M Schon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
No abstract text is available yet for this article.
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27994720/repair-potential-of-matrix-induced-bone-marrow-aspirate-concentrate-and-matrix-induced-autologous-chondrocyte-implantation-for-talar-osteochondral-repair-patterns-of-some-catabolic-inflammatory-and-pain-mediators
#11
Giovanna Desando, Isabella Bartolotti, Francesca Vannini, Carola Cavallo, Francesco Castagnini, Roberto Buda, Sandro Giannini, Massimiliano Mosca, Erminia Mariani, Brunella Grigolo
OBJECTIVE: The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Aspirate Concentrate (mBMAC) and matrix-induced Autologous Chondrocyte Implantation (mACI) evaluating, on a small number of osteochondral biopsies, the expression of some catabolic, inflammatory, and pain mediators...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994719/operative-treatment-for-osteochondral-lesions-of-the-talus-biologics-and-scaffold-based-therapy
#12
REVIEW
Youichi Yasui, Adi Wollstein, Christopher D Murawski, John G Kennedy
OBJECTIVE: Numerous basic science articles have published evidence supporting the use of biologic augmentation in the treatment of osteochondral lesions of the talus (OLT). However, a comprehensive evaluation of the clinical outcomes of those treatment modalities in OLT has yet to be published. The purpose of this review is to provide an evidence-based overview of clinical outcomes following biologic augmentation to surgical treatments for OLT. DESIGN: A comprehensive literature review was performed...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27943520/evaluation-of-anatomical-and-functional-results-of-overlapping-anal-sphincter-repair-with-or-without-the-injection-of-bone-marrow-aspirate-concentrate-a-case-control-study
#13
W W Khafagy, M M El-Said, W M Thabet, S E-S Aref, W Omar, S H Emile, H Elfeki, M S El-Ghonemy, M T El-Shobaky
AIM: Overlapping anal sphincter repair (OASR) is used for treatment of faecal incontinence due to an external anal sphincter (EAS) defect; however, it is not the optimal treatment as its functional results tend to deteriorate significantly with time. The present study aimed to evaluate the effect of local injection of bone marrow aspirate concentrate (BMAC) on the outcome of OASR. METHOD: We compared a prospective group of 20 patients with EAS defect who were managed with OASR and BMAC injection (group I) with a historical control group of an equal number of patients managed with OASR alone (group II)...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27909656/outcomes-of-demineralized-bone-matrix-enriched-with-concentrated-bone-marrow-aspirate-in-lumbar-fusion
#14
Remi M Ajiboye, Mark A Eckardt, Jason T Hamamoto, Benjamin Plotkin, Michael D Daubs, Jeffrey C Wang
BACKGROUND: Multiple studies have demonstrated that a significant amount of variability exists in various demineralized bone matrix (DBM) formulations, which casts doubts on its reliability in consistently promoting fusion. Bone marrow aspirate (BMA) is a cellular based graft that contains mesenchymal stem cells (MSCs) and growth factors can confer osteogenic and osteoinductive potential to DBM. The goal of this study was to describe the outcome of DBM enriched with concentrated BMA in patients undergoing combined lumbar interbody and posterolateral fusion...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27908574/reconstruction-of-a-post-traumatic-maxillary-ridge-using-a-radial-forearm-free-flap-and-immediate-tissue-engineering-bone-morphogenetic-protein-bone-marrow-aspirate-concentrate-and-cortical-cancellous-bone-case-report
#15
James C Melville, Ramzey Tursun, J Marshall Green, Robert E Marx
The purpose of this article is to describe reconstruction of the maxillary alveolar ridge by use of a microvascular free flap combined with an immediate tissue-engineered bone graft. This novel surgical technique involved the use of a radial forearm free flap and immediate allogeneic avascular bone graft augmented with bone morphogenetic protein and bone marrow aspirate concentrate. A poly-d,l-lactic acid mesh was used as a containment unit for the bone graft. The patient was successfully treated with a viable radial forearm free flap for soft tissue and regeneration of bone with adequate height and width, which allowed the placement of 3 dental implants with excellent arch coordination...
February 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27903929/a-comparison-of-outcomes-of-particulated-juvenile-articular-cartilage-and-bone-marrow-aspirate-concentrate-for-articular-cartilage-lesions-of-the-talus
#16
Nathan S Lanham, John J Carroll, Minton T Cooper, Venkat Perumal, Joseph S Park
Background Articular cartilage lesions of the talus remain a challenging clinical problem because of the lack of natural regeneration and limited treatment options. Microfracture is often the first-line therapy, however lesions larger than 1.5 cm(2) have been shown to not do as well with this treatment method. Methods The objective of this retrospective study was to evaluate the outcomes of iliac crest bone marrow aspirate concentrate/collagen scaffold (ICBMA) and particulated juvenile articular cartilage (PJAC) for larger articular cartilage lesions of the talus...
November 30, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27900365/genome-sequencing-in-a-case-of-niemann-pick-type-c
#17
Max Dougherty, John Lazar, Jason C Klein, Karina Diaz, Theodore Gobillot, Eli Grunblatt, Nicholas Hasle, Daniel Lawrence, Megan Maurano, Maria Nelson, Gregory Olson, Sanjay Srivatsan, Jay Shendure, C Dirk Keene, Thomas Bird, Marshall S Horwitz, Desiree A Marshall
Adult-onset Niemann-Pick disease type C (NPC) is an infrequent presentation of a rare neurovisceral lysosomal lipid storage disorder caused by autosomal recessive mutations in NPC1 (∼95%) or NPC2 (∼5%). Our patient was diagnosed at age 33 when he presented with a 10-yr history of difficulties in judgment, concentration, speech, and coordination. A history of transient neonatal jaundice and splenomegaly with bone marrow biopsy suggesting a lipid storage disorder pointed to NPC; biochemical ("variant" level cholesterol esterification) and ultrastructural studies in adulthood confirmed the diagnosis...
November 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27871420/platelet-rich-plasma-and-concentrated-bone-marrow-aspirate-in-surgical-treatment-for-osteochondral-lesions-of-the-talus
#18
REVIEW
Youichi Yasui, Andrew W Ross, John G Kennedy
Platelet-rich plasma (PRP) and concentrated bone marrow aspirate (CBMA) have the potential to improve the quality of cartilage repair in osteochondral lesions of the talus (OLT). In this review, we describe the basic science and clinical evidence that has been published on the topic of PRP and CBMA on 2 commonly used surgical techniques for the treatment of OLT: bone marrow stimulation and osteochondral autograft transfer.
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27871416/bone-marrow-aspirate-concentrate-for-bone-healing-in-foot-and-ankle-surgery
#19
REVIEW
Joshua S Harford, Travis J Dekker, Samuel B Adams
Autologous bone marrow aspirate concentrate (BMAC) has become a popular orthobiologic to augment bone healing. The potential benefit comes from osteoprogenitor cells and growth factors that can lead to new bone formation in the setting of foot and ankle arthrodesis procedures. BMAC has an excellent safety record and has demonstrated efficacy in animal models of bone healing. Although scant, the literature on the use of BMAC in foot and ankle surgery does demonstrate promise for this orthobiologic adjuvant.
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#20
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
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