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Bone marrow aspirate concentration

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https://www.readbyqxmd.com/read/29924032/usefulness-of-tocilizumab-for-treating-rheumatoid-arthritis-with-myelodysplastic-syndrome-a-case-report-and-literature-review
#1
Chuanyin Sun, Yingwan Luo, Hongyan Tong, Guanhua Xu, Jin Lin
RATIONALE: Dysregulated immune function in rheumatoid arthritis (RA) might lead to the development of myelodysplastic syndrome (MDS). Serum interleukin-6 (IL-6) concentrations are increased in both RA and MDS patients. PATIENT CONCERNS: A 58-year-old woman presented with severe RA. During a recent 8-month period, the patient experienced swelling in multiple joints, dizziness, and severe anemia. The symptoms responded poorly to oral corticosteroids and methotrexate (MTX)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29913658/warmed-and-buffered-lidocaine-for-pain-relief-during-bone-marrow-aspiration-and-biopsy-a-randomized-and-controlled-trial
#2
Anna-Maria Kuivalainen, Freja Ebeling, Per Rosenberg
Background and purpose Local infiltration anaesthesia is frequently painful due to low pH of the used anaesthetics, such as lidocaine. Usually pH of the solution is near 4.0, which causes tissue irritation and excitation of the pain mediating nerve endings. Warming and buffering the local anaesthetic solution have been shown to reduce the patient's experience of pain and unpleasantness during infiltration. Buffering reduces the dissociation of the local anaesthetic molecule and may enhance the anaesthetic's entrance into nerve cells...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911602/nitrous-oxide-analgesia-for-bone-marrow-aspiration-and-biopsy-a-randomized-controlled-and-patient-blinded-study
#3
Anna-Maria Kuivalainen, Freja Ebeling, Eira Poikonen, Per H Rosenberg
Background and aims Bone marrow aspiration and/or biopsy (BMAB), performed under local anaesthesia in adults, is a common and often painful procedure. Anxiety is known to intensify pain during the procedure. Nitrous oxide (N2O), known for its sedative and analgesic benefit in various short medical procedures and labour pain, could be advantageous also for pain relief during bone marrow examination. N2O acts rapidly and is eliminated in a couple of minutes once the inhalation is stopped, and occasional side effects (e...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29898646/pure-bone-marrow-aspirate-injection-for-chronic-greater-trochanteric-pain-syndrome-a-case-report
#4
Rachel G Henderson, Ricardo E Colberg
There are limited treatment options for patients with a chronic refractory greater trochanteric pain syndrome. Orthobiologic interventions may stimulate tendon healing and improve pain and function in patients who fail the standard conservative treatment. Since the US FDA's new position statement regarding the centrifugation of bone marrow aspirate products as a potentially 'more than minimally manipulated' product, there is a growing concern about the most common bone marrow aspirate concentrate technique...
July 1, 2018: Pain Management
https://www.readbyqxmd.com/read/29868619/ultrasonographic-findings-in-41-dogs-treated-with-bone-marrow-aspirate-concentrate-and-platelet-rich-plasma-for-a-supraspinatus-tendinopathy-a-retrospective-study
#5
Renee A McDougall, Sherman O Canapp, Debra A Canapp
Objective: To report sonographic findings for dogs with a supraspinatus tendinopathy (ST) treated with an ultrasound-guided intratendinous injection of bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP). Methods: Medical records for dogs diagnosed with an ST and treated with a BMAC-PRP injection were reviewed. Data collected included patient signalment, radiographic findings at the time of initial evaluation, and sonographic findings, including cross-sectional area (CSA), fiber pattern, and echogenicity...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29868410/bone-marrow-aspirate-concentrate-and-microfracture-technique-for-talar-osteochondral-lesions-of-the-ankle
#6
Evelyn P Murphy, Christopher Fenelon, Niall P McGoldrick, Stephen R Kearns
Osteochondral lesions of the talus refer to a chondral or subchondral defect of the articular cartilage and potentially the underlying bone. Ankle sprains are an extremely common injury; approximately 27,000 ankle sprains occur per day in America. Fifty percent of these can lead to a cartilage injury to the ankle. There has been a high quoted rate of failure with conservative measures of up to 45% in some series. Surgical options are largely broken down into 2 groups, namely, reparative or regenerative treatments...
April 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29777422/patellofemoral-cartilage-repair
#7
REVIEW
Alexandre Barbieri Mestriner, Jakob Ackermann, Andreas H Gomoll
PURPOSE OF REVIEW: This review provides an overview of well-established and newly developed cartilage repair techniques for cartilage defects in the patellofemoral joint (PFJ). An algorithm will be presented for approaching cartilage defects considering the distinct anatomy of both the patellar and trochlear articular surfaces. RECENT FINDINGS: Recent studies on cartilage repair in the PFJ have demonstrated improved outcomes in an attempt to delay or obviate the need for arthroplasty, and improve symptoms in young patients...
June 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29776486/refractory-knee-osteoarthritis-adipose-derived-stromal-cells-versus-bone-marrow-aspiration-concentrate
#8
EDITORIAL
Gerard A Malanga, Samuel Dona, Joanne Borg-Stein, Michael Auriemma, Jaspal R Singh
No abstract text is available yet for this article.
May 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29759151/circulating-tumour-dna-for-detecting-minimal-residual-disease-in-multiple-myeloma
#9
REVIEW
Trevor J Pugh
Circulating tumor DNA faithfully recapitulates somatic mutations detected in bone marrow aspirates from patients with newly diagnosed or relapsed or recurrent myeloma. Extending these methods to enable detection of minimal residual disease will require increased sensitivity and breadth of genomic assays to maximize information content from small quantities of cell-free DNA; as well as definition of a clinically meaningful ctDNA concentration in comparison with conventional bone marrow cell-count thresholds...
January 2018: Seminars in Hematology
https://www.readbyqxmd.com/read/29736332/behavior-and-biocompatibility-of-rabbit-bone-marrow-mesenchymal-stem-cells-with-bacterial-cellulose-membrane
#10
Marcello de Alencar Silva, Yulla Klinger de Carvalho Leite, Camila Ernanda Sousa de Carvalho, Matheus Levi Tajra Feitosa, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Bartolomeu Cruz Viana Neto, Maria Angélica Miglino, Angela Faustino Jozala, Maria Acelina Martins de Carvalho
Background: Tissue engineering has been shown to exhibit great potential for the creation of biomaterials capable of developing into functional tissues. Cellular expansion and integration depends on the quality and surface-determinant factors of the scaffold, which are required for successful biological implants. The objective of this research was to characterize and evaluate the in vitro characteristics of rabbit bone marrow mesenchymal stem cells (BM-MSCs) associated with a bacterial cellulose membrane (BCM)...
2018: PeerJ
https://www.readbyqxmd.com/read/29717624/chondrogenic-differentiation-processes-in-human-bone-marrow-aspirates-seeded-in-three-dimensional-woven-poly-%C3%A9-caprolactone-scaffolds-enhanced-by-recombinant-adeno-associated-virus-mediated-sox9-gene-transfer
#11
Jagadeesh K Venkatesan, Franklin T Moutos, Ana Rey-Rico, Bradley T Estes, Janina Frisch, Gertrud Schmitt, Henning Madry, Farshid Guilak, Magali Cucchiarini
Combining gene therapy approaches with tissue engineering procedures is an active area of translational research for the effective treatment of articular cartilage lesions, especially to target chondrogenic progenitor cells such as those derived from the bone marrow. This study evaluated the effect of genetically modifying concentrated human mesenchymal stem cells from bone marrow to induce chondrogenesis by recombinant adeno-associated virus (rAAV) vector gene transfer of the sex-determining region Y-type high-mobility group box 9 (SOX9) factor upon seeding in three-dimensional-woven poly(ɛ-caprolactone; PCL) scaffolds that provide mechanical properties mimicking those of native articular cartilage...
June 11, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29705871/mid-term-results-of-concentrated-autologous-bone-marrow-aspirate-transplantation-for-corticosteroid-associated-osteonecrosis-of-the-femoral-head-in-systemic-lupus-erythematosus
#12
Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Yukiyo Shimizu, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki, Hajime Mishima
PURPOSE: We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head (ONFH). This study aimed to evaluate the effects of CABMAT as a hip-preserving surgical approach, preventing conversion to total hip arthroplasty (THA) and femoral head collapse in patients with systemic lupus erythematosus (SLE). METHODS: Since 2003, 52 SLE patients (8 male, 44 female, 92 hips, mean age 35...
April 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29696307/stem-cell-therapy-in-bilateral-osteonecrosis-computer-assisted-surgery-versus-conventional-fluoroscopic-technique-on-the-contralateral-side
#13
Philippe Hernigou, Benjamin Thiebaut, Victor Housset, Claire Bastard, Yasuhiro Homma, Younes Chaib, Charles Henri Flouzat Lachaniette
PURPOSE: Surgical management of osteonecrosis with core decompression with stem cell therapy is a new procedure. The technique is performed with fluoroscopic guidance. This study attempts to determine if computer-navigated technique can improve the procedure. METHODS: Thirty consecutive patients with bilateral symptomatic osteonecrosis without collapse were included in this study during the year 2011. A prospective, randomized, and controlled study was conducted on 60 hips (bilateral osteonecrosis) using conventional fluoroscopy technique on one side and computer-based navigation on the contralateral side...
April 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29682351/comparative-analysis-of-cellular-and-growth-factor-composition-in-bone-marrow-aspirate-concentrate-and-platelet-rich-plasma
#14
Hisashi Sugaya, Tomokazu Yoshioka, Toshiki Kato, Yu Taniguchi, Hiroshi Kumagai, Kojiro Hyodo, Osamu Ohneda, Masashi Yamazaki, Hajime Mishima
The purpose of this study was to quantify the stem cell and growth factor (GF) contents in the bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP) prepared from whole blood using a protocol established in our laboratory. We examined 10 patients with osteonecrosis of the femoral head who were treated by autologous BMAC transplantation at our hospital between January 2015 and June 2015. We quantified CD34+ and CD31-CD45-CD90+CD105+ cells in BMAC and PRP by flow cytometry. Additionally, we measured various GFs, that is, basic fibroblast growth factor (b-FGF), platelet-derived growth factor-BB (PDGF-BB), vascular endothelial growth factor (VEGF), transforming growth factor- β 1 (TGF- β 1), and bone morphogenetic protein-2 (BMP-2) in BMAC and PRP using enzyme-linked immunosorbent assays and statistical analyses...
2018: Bone Marrow Research
https://www.readbyqxmd.com/read/29652173/a-review-of-commercially-available-point-of-care-devices-to-concentrate-bone-marrow-for-the-treatment-of-osteoarthritis-and-focal-cartilage-lesions
#15
Florian Gaul, William D Bugbee, Heinz R Hoenecke, Darryl D D'Lima
Objective Mesenchymal stem cells (MSCs) are a promising cell-based therapy treatment option for several orthopedic indications. Because culture expansion of MSC is time and cost intensive, a bedside concentration of bone marrow (BM) aspirate is used as an alternative. Many commercial systems are available but the available literature and knowledge regarding these systems is limited. We compared different point-of-care devices that concentrate BM (BMC) by focusing on technical features and quality parameters to help surgeons make informed decisions while selecting the appropriate device...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29644089/heterotopic-bone-formation-in-the-musculus-latissimus-dorsi-of-sheep-using-%C3%AE-tricalcium-phosphate-scaffolds-evaluation-of-different-seeding-techniques
#16
Simon Spalthoff, Rüdiger Zimmerer, Jan Dittmann, Horst Kokemüller, Marco Tiede, Laura Flohr, Philippe Korn, Nils-Claudius Gellrich, Philipp Jehn
Osseous reconstruction of large bone defects remains a challenge in oral and maxillofacial surgery. In addition to autogenous bone grafts, which despite potential donor-site mobility still represent the gold standard in reconstructive surgery, many studies have investigated less invasive alternatives such as in vitro cultivation techniques. This study compared different types of seeding techniques on pure β-tricalcium phosphate scaffolds in terms of bone formation and ceramic resorption in vivo . Cylindrical scaffolds loaded with autologous cancellous bone, venous blood, bone marrow aspirate concentrate or extracorporeal in vitro cultivated bone marrow stromal cells were cultured in sheep on a perforator vessel of the musculus latissimus dorsi over a 6-month period...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29628381/biological-treatment-for-osteoarthritis-of-the-knee-moving-from-bench-to-bedside-current-practical-concepts
#17
Jorge Chahla, Bert R Mandelbaum
Biological-based therapies for cartilage pathology have gained considerable recognition in the last few decades due to their potential benefits including their minimal invasiveness, capacity for unprecedented healing, and potential for rapid recovery. Consequently, these therapies are likely to have the most noteworthy impact on patients with degenerative joint changes who want to remain active. Currently, the most researched treatments include platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and cell-based therapies...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29622266/editorial-commentary-not-all-bone-marrow-aspirate-concentrates-are-the-same-the-necessity-of-detailed-reporting-and-other-lessons-learned-from-cell-based-treatments-in-orthopaedics
#18
EDITORIAL
Nikolaos K Paschos
Bone marrow aspirate concentrates have become a popular therapeutic approach for several musculoskeletal conditions. A plethora of different preparations exist that make difficult to evaluate their clinical outcome and, thus, to make safe conclusions for their effectiveness. The first step for this assessment is comprehensive and reliable reporting of all the important variables that would allow characterization of their content and properties. This is critical for the understanding of their mechanism of action and the identification of the proper indications based on patient and disorder characteristics that could potentially lead to their effective application in clinical scenarios...
April 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29619500/early-stage-osteonecrosis-of-the-femoral-head-where-are-we-and-where-are-we-going-in-year-2018
#19
REVIEW
Eric Larson, Lynne C Jones, Stuart B Goodman, Kyung-Hoi Koo, Quanjun Cui
Osteonecrosis of the femoral head (ONFH) is a devastating condition affecting relatively young patients whereby the femoral head is necrotic, resulting in significant pain, articular surface collapse, and eventual osteoarthritis. This condition has been highly associated with chronic steroid use, alcoholism, and hip trauma, as well as other less common conditions. Without intervention, this condition has a high likelihood of progressing and developing into end-stage osteoarthritis. Unfortunately, ONFH is difficult to diagnose on plain radiographs in the early stages of the disease, and often requires more advanced imaging modalities such as MRI in order to fully assess for early degeneration...
April 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29600207/treating-a-recalcitrant-non-union-of-the-radius-using-autogenous-bone-equine-bone-paste-equine-demineralized-bone-matrix-platelet-rich-plasma-and-bone-marrow-aspirate-a-case-report
#20
Ferdinando Da Rin De Lorenzo
Introduction: Non-unions at forearms are usually challenging and difficult to treat. If additionally, an infection is present, reconstructive surgery should be planned only after full debridement, antibiotic treatment, and confirmation, based on clinical observation and laboratory tests that the infection has subsided. Bone grafting may be required for reconstruction. The use of autogenous bone calls for a second surgical site with an increased risk of morbidity. Using bone substitutes may reduce the need for autogenous bone...
November 2017: Journal of Orthopaedic Case Reports
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