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https://www.readbyqxmd.com/read/28622926/hominid-visitation-of-the-moravian-karst-during-the-middle-upper-paleolithic-transition-new-results-from-pod-hradem-cave-czech-republic
#1
L Nejman, R Wood, D Wright, L Lisá, Z Nerudová, P Neruda, A Přichystal, J Svoboda
In 1956-1958, excavations of Pod Hradem Cave in Moravia (eastern Czech Republic) revealed evidence for human activity during the Middle-Upper Paleolithic transition. This spanned 25,050-44,800 cal BP and contained artefacts attributed to the Aurignacian and Szeletian cultures, including those made from porcelanite (rarely used at Moravian Paleolithic sites). Coarse grained excavation techniques and major inversions in radiocarbon dates meant that site chronology could not be established adequately. This paper documents re-excavation of Pod Hradem in 2011-2012...
July 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28608289/-antibiotic-stewardship-a%C3%A2-programmatic-approach-to-improved-antimicrobial-management
#2
REVIEW
Martin Müller, Patrick Lehmann, Christian Willy
Due to the increasing selection and prevalence of multidrug-resistant gram-negative bacteria and the insufficient development of novel antibiotics, the responsible and prudent use of the available antimicrobial drugs is of major importance. In Germany the rational use of anti-infectives considering the local antimicrobial resistance situation is defined in the infection protection act of 2011. An important tool to follow legal regulations and to improve the treatment of bacterial infections is the antimicrobial stewardship (AMS) concept...
June 12, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28539060/a-systematic-review-of-antimicrobial-stewardship-interventions-in-the-emergency-department
#3
Mia Losier, Tasha D Ramsey, Kyle John Wilby, Emily K Black
BACKGROUND/OBJECTIVE: To improve antimicrobial utilization, development and implementation of antimicrobial stewardship programs in the emergency department (ED) has been recommended. The primary objective of this review was to characterize antimicrobial stewardship (AMS) in the ED and to identify interventions that improve patient outcomes or process of care and/or reduce consequences of antimicrobial use. METHODS: This study was completed as a systematic review...
May 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28520865/impact-of-an-integrated-antibiotic-allergy-testing-program-on-antimicrobial-stewardship-a-multicenter-evaluation
#4
Jason A Trubiano, Karin A Thursky, Andrew J Stewardson, Karen Urbancic, Leon J Worth, Cheryl Jackson, Wendy Stevenson, Michael Sutherland, Monica A Slavin, M Lindsay Grayson, Elizabeth J Phillips
Background.: Despite the high prevalence of patient-reported antibiotic allergy (so-called antibiotic allergy labels [AALs]) and their impact on antibiotic prescribing, incorporation of antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) is not widespread. We aimed to evaluate the impact of an AAT-AMS program on AAL prevalence, antibiotic usage, and appropriateness of prescribing. Methods.: AAT-AMS was implemented at two large Australian hospitals during a 14-month period beginning May 2015...
May 18, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28463922/ultrasound-screening-for-posterior-shoulder-dislocation-in-infants-with-persistent-brachial-plexus-birth-palsy
#5
Andrea S Bauer, Justin F Lucas, Nasser Heyrani, Ryan L Anderson, Leslie A Kalish, Michelle A James
BACKGROUND: Early detection of posterior shoulder dislocation in infants with brachial plexus birth palsy (BPBP) is essential, but it may be difficult to accomplish with physical examination alone. The aim of this study was to determine the prevalence of shoulder dislocation in patients with BPBP using ultrasound and to identify which physical examination measurements correlated most with dislocation in these patients. METHODS: This study was a retrospective review of data obtained in an ultrasound screening program of infants with BPBP born from January 2011 to April 2014...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28424069/ankplex-algorithmic-structure-for-refinement-of-near-native-ankyrin-protein-docking
#6
Tanchanok Wisitponchai, Watshara Shoombuatong, Vannajan Sanghiran Lee, Kuntida Kitidee, Chatchai Tayapiwatana
BACKGROUND: Computational analysis of protein-protein interaction provided the crucial information to increase the binding affinity without a change in basic conformation. Several docking programs were used to predict the near-native poses of the protein-protein complex in 10 top-rankings. The universal criteria for discriminating the near-native pose are not available since there are several classes of recognition protein. Currently, the explicit criteria for identifying the near-native pose of ankyrin-protein complexes (APKs) have not been reported yet...
April 19, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28421818/cell-origin-dictates-programming-of-resident-versus-recruited-macrophages-during-acute-lung-injury
#7
Kara J Mould, Lea Barthel, Michael P Mohning, Stacey M Thomas, Alexandra L McCubbrey, Thomas Danhorn, Sonia M Leach, Tasha E Fingerlin, Brian P O'Connor, Julie A Reisz, Angelo D'Alessandro, Donna L Bratton, Claudia V Jakubzick, William J Janssen
Two populations of alveolar macrophages (AMs) co-exist in the inflamed lung: resident AMs that arise during embryogenesis, and recruited AMs that originate postnatally from circulating monocytes. The objective of this study was to determine whether origin or environment dictates the transcriptional, metabolic, and functional programming of these two ontologically distinct populations over the time course of acute inflammation. RNA sequencing demonstrated marked transcriptional differences between resident and recruited AMs affecting three main areas: proliferation, inflammatory signaling, and metabolism...
April 19, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28012623/investigating-the-within-herd-prevalence-and-risk-factors-for-ketosis-in-dairy-cattle-in-ontario-as-diagnosed-by-the-test-day-concentration-of-%C3%AE-hydroxybutyrate-in-milk
#8
Elise H Tatone, Todd F Duffield, Stephen J LeBlanc, Trevor J DeVries, Jessica L Gordon
An observational study of 790 to over 3,000 herds was conducted to estimate the within-herd prevalence and cow-level risk factors for ketosis in dairy cattle in herds that participate in a Dairy Herd Improvement Association (DHIA) program. Ketosis or hyperketolactia (KET) was diagnosed as milk β-hydroxybutyrate ≥0.15 mmol/L at first DHIA test when tested within the first 30 d in milk. Seven hundred ninety-five herds providing at least 61 first milk tests from June 2014 to December 2015 were used to estimate the provincial within-herd prevalence of KET...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27994621/antimicrobial-stewardship-a-cross-sectional-survey-assessing-the-perceptions-and-practices-of-community-pharmacists-in-ethiopia
#9
Daniel Asfaw Erku
Background. Community pharmacists are key healthcare professionals for antimicrobial stewardship programs owing to their role in dispensing of antimicrobials. The aim of the present study was to assess the perception and practices of community pharmacists towards antimicrobial stewardship (AMS) in Ethiopia. Methods. A cross-sectional survey was conducted by selecting pharmacy sites through stratified simple random sampling technique. Descriptive and inferential statistics were used to analyze the data. Results...
2016: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/27986824/the-intersection-of-antimicrobial-stewardship-and-microbiology-educating-the-next-generation-of-health-care-professionals
#10
Lauren A O'Donnell, Anthony J Guarascio
With the alarming rise of antibiotic resistance, clinical professionals are called upon to manage antibiotic therapies using the most relevant and recent clinical and laboratory data. To this end, antimicrobial stewardship (AMS) programs aim to reduce unnecessary or suboptimal use of antibiotics while maximizing outcomes for the patient. For AMS programs to succeed, the active participation of clinical professionals at all levels of patient care is required. Although programs exist to train established clinicians in AMS, there is a paucity of literature on how and when to integrate AMS concepts and skills in pre-clinical and clinical coursework...
January 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27980377/temporal-trends-of-healthcare-associated-infections-and-antimicrobial-use-in-2011-2013-observed-with-annual-point-prevalence-surveys-in-ferrara-university-hospital-italy
#11
REVIEW
P Antonioli, M C Manzalini, A Stefanati, B Bonato, A Verzola, A Formaglio, G Gabutti
INTRODUCTION: Healthcare associated infections (HAIs) and misuse of antimicrobials (AMs) represent a growing public health problem. The Point Prevalence Surveys (PPSs) find available information to be used for specific targeted interventions and evaluate their effects. The objective of this study was to estimate the prevalence of HAIs and AM use, to describe types of infections, causative pathogens and to compare data collected through three PPSs in Ferrara University Hospital (FUH), repeated in 3 different years (2011-2013)...
September 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/27659237/validation-of-a-novel-activity-monitor-in-impaired-slow-walking-crutch-supported-patients
#12
Simon N van Laarhoven, Matthijs Lipperts, Stijn A A N Bolink, Rachel Senden, Ide C Heyligers, Bernd Grimm
BACKGROUND: A growing need in clinical practice of rehabilitation and orthopaedic medicine is for objective outcome tools to estimate physical activity. Current techniques show limited validity or are too demanding for routine clinical use. Accelerometer-based activity monitors (AMs) have shown promise for measuring physical activity in healthy people but lack validity in impaired patients. OBJECTIVES: This study aimed to validate an accelerometer-based AM in impaired, slow-walking, crutch-supported patients after total joint arthroplasty (TJA)...
December 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27579865/into-the-past-a-step-towards-a-robust-kimberley-rock-art-chronology
#13
June Ross, Kira Westaway, Meg Travers, Michael J Morwood, John Hayward
The recent establishment of a minimum age estimate of 39.9 ka for the origin of rock art in Sulawesi has challenged claims that Western Europe was the locus for the production of the world's earliest art assemblages. Tantalising excavated evidence found across northern Australian suggests that Australia too contains a wealth of ancient art. However, the dating of rock art itself remains the greatest obstacle to be addressed if the significance of Australian assemblages are to be recognised on the world stage...
2016: PloS One
https://www.readbyqxmd.com/read/27550321/cultural-challenges-when-developing-anti-tobacco-messages-for-indigenous-australians
#14
Gillian Sandra Gould, Leah C Stevenson, Yvonne Cadet-James, Alan R Clough
Recently, many programs have been funded to tackle Indigenous Australian smoking. This study assessed what challenges and unexpected responses could occur when developing anti-tobacco messages for Indigenous communities. A cross-sectional telephone survey of organizations involved in making anti-tobacco messages for the target population was conducted in 2012-2013. Open-ended questions explored cultural challenges to message development and unexpected outcomes. Responses were noted and these qualitative data were independently coded by two researchers using an inductive analysis...
August 22, 2016: Health Promotion International
https://www.readbyqxmd.com/read/27414687/seven-passive-1-h-hypoxia-exposures-do-not-prevent-ams-in-susceptible-individuals
#15
Martin Faulhaber, Elena Pocecco, Hannes Gatterer, Martin Niedermeier, Maike Huth, Tobias Dünnwald, Verena Menz, Luciano Bernardi, Martin Burtscher
PURPOSE: The present study evaluated the effects of a pre-acclimatization program comprising 7 passive 1-hour exposures to 4,500 m normobaric hypoxia on the prevalence and severity of acute mountain sickness (AMS) during a subsequent exposure to real high altitude in persons susceptible to AMS. METHODS: The project was designed as a randomized controlled trial including 32 healthy female and male participants with known susceptibility to AMS symptoms. After baseline measurements participants were randomly assigned to the hypoxia or the control group to receive the pre-acclimatization program (7 passive 1-hour exposures within 7 days to normobaric hypoxia or sham hypoxia)...
July 12, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27306971/the-relationship-between-academic-motivation-and-lifelong-learning-during-residency-a-study-of-psychiatry-residents
#16
Sanjeev Sockalingam, David Wiljer, Shira Yufe, Matthew K Knox, Mark Fefergrad, Ivan Silver, Ilene Harris, Ara Tekian
PURPOSE: To examine the relationship between lifelong learning (LLL) and academic motivation for residents in a psychiatry residency program, trainee factors that influence LLL, and psychiatry residents' LLL practices. METHOD: Between December 2014 and February 2015, 105 of 173 (61%) eligible psychiatry residents from the Department of Psychiatry, University of Toronto, completed a questionnaire with three study instruments: an LLL needs assessment survey, the Jefferson Scale of Physician Lifelong Learning (JeffSPLL), and the Academic Motivation Scale (AMS)...
October 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27280941/availability-of-on-site-acute-vascular-interventional-radiology-techniques-performed-by-trained-acute-care-specialists-a-single-emergency-center-experience
#17
Junya Tsurukiri, Shoichi Ohta, Shiro Mishima, Hiroshi Homma, Eitaro Okumura, Itsuro Akamine, Masahito Ueno, Jun Oda, Tetsuo Yukioka
INTRODUCTION: Comprehensive treatment of a patient in acute medicine and surgery requires the use of both surgical techniques and other treatment methods. Recently, acute vascular interventional radiology techniques (AVIRTs) have become increasingly popular, enabling adequately trained in-house experts to improve the quality of on-site care. METHODS: After obtaining approval from our institutional ethics committee, we conducted a retrospective study of AVIRT procedures performed by acute care specialists trained in acute medicine and surgery over a 1-year period, including those conducted out of hours...
January 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27046542/the-impact-of-early-human-data-on-clinical-development-there-is-time-to-win
#18
Piet Swart, Frederic Lozac'h, Marjorie Simon, Esther van Duijn, Wouter H J Vaes
Modern accelerator mass spectrometry (AMS) methods enable the routine application of this technology in drug development. By the administration of a (14)C-labelled microdose or microtrace, pharmacokinetic (PK) data, such as mass balance, metabolite profiling, and absolute bioavailability (AB) data, can be generated easier, faster, and at lower costs. Here, we emphasize the advances and impact of this technology for pharmaceutical companies. The availability of accurate intravenous (iv) PK and human absorption, distribution, metabolism, and excretion (ADME) information, even before or during Phase I trials, can improve the clinical development plan...
June 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/26949695/automatic-mode-switch-ams-causes-less-synchronization
#19
Mohammadvahid Jorat, Mohammadhossein Nikoo
INTRODUCTION: Cardiac resynchronization devices are part of modern heart failure management. After implantation, we analyze and program devices in an attempt to ensure their success. Biventricular pacing should be 98% or more for the lowest mortality and best symptom improvement. CASE PRESENTATION: In this case series, we present a combination of far field sensing and automatic mode switching (AMS) in six patients. It is found that this combination causes ventricular sensing (VS) episodes with wide QRS and no synchronization...
May 2016: Research in Cardiovascular Medicine
https://www.readbyqxmd.com/read/26855009/evaluating-a-health-video-on-diabetic-retinopathy
#20
Joos Meyer, Karim Johnson, Joshua Bowyer, Josephine Muir, Angus Turner
Issue addressed Indigenous Australians are 14 times more likely than non-Indigenous Australians to develop diabetic retinopathy (DR). Blindness can be prevented in 98% of cases if DR is identified and treated early. While the National Health and Medical Research Council recommend annual screening for Indigenous Australians, screening attendance rates remain low. The objective of this study was to evaluate whether a targeted health promotion intervention improved patient compliance and screening rates. Methods Bad Sugars, Bad Eyes - a culturally appropriate video targeting DR awareness and the importance of screening among Indigenous Australians - was developed at the Lions Eye Institute, Western Australia...
April 2016: Health Promotion Journal of Australia
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