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https://www.readbyqxmd.com/read/29573053/barriers-to-and-enablers-of-implementing-antimicrobial-stewardship-programs-in-veterinary-practices
#1
Laura Y Hardefeldt, J R Gilkerson, H Billman-Jacobe, M A Stevenson, K Thursky, K E Bailey, G F Browning
BACKGROUND: Antimicrobial stewardship (AMS) programs are yet to be widely implemented in veterinary practice and medical programs are unlikely to be directly applicable to veterinary settings. OBJECTIVE: To gain an in-depth understanding of the factors that influence effective AMS in veterinary practices in Australia. METHODS: A concurrent explanatory mixed methods design was used. The quantitative phase of the study consisted of an online questionnaire to assess veterinarians' attitudes to antimicrobial resistance (AMR) and antimicrobial use in animals, and the extent to which AMS currently is implemented (knowingly or unknowingly)...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29572691/fluoroquinolone-restriction-as-an-effective-antimicrobial-stewardship-intervention
#2
REVIEW
Kimberly C Claeys, Teri L Hopkins, Ana D Vega, Emily L Heil
PURPOSE OF REVIEW: Fluoroquinolones are a commonly prescribed antibiotic class that has come under scrutiny in recent years due to mounting evidence of association between adverse drug events, C. difficile infection and isolation of antibiotic-resistant bacteria. RECENT FINDINGS: Inpatient antimicrobial stewardship (AMS) programs have a toolbox of potential interventions to curb inappropriate antibiotic use, prevent antibiotic-associated adverse drug events, and avoid unnecessary costs of care...
March 23, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29403295/knowledge-of-community-pharmacists-about-antibiotics-and-their-perceptions-and-practices-regarding-antimicrobial-stewardship-a-cross-sectional-study-in-punjab-pakistan
#3
Muhammad Rehan Sarwar, Anum Saqib, Sadia Iftikhar, Tayyaba Sadiq
Objective: To evaluate the knowledge of community pharmacists about antibiotics, and their perceptions and practices toward antimicrobial stewardship (AMS) in Punjab, Pakistan. Materials and methods: A descriptive cross-sectional study was conducted among community pharmacists in Punjab, Pakistan from April 1, 2017 to May 31, 2017. A self-administered and pretested questionnaire was used for data collection. A simple random-sampling method was used to select community pharmacies...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29340593/the-clinical-utility-of-methicillin-resistant-staphylococcus-aureus-mrsa-nasal-screening-to-rule-out-mrsa-pneumonia-a-diagnostic-meta-analysis-with-antimicrobial-stewardship-implications
#4
Diane M Parente, Cheston B Cunha, Eleftherios Mylonakis, Tristan T Timbrook
Background: Recent literature has highlighted MRSA nasal screening as a possible antimicrobial stewardship program (ASP) tool for avoiding unnecessary empiric MRSA therapy for pneumonia, yet current guidelines recommend MRSA therapy based on risk factors. The objective of this meta-analysis was to evaluate the diagnostic value of MRSA nasal screening in MRSA pneumonia. Methods: Pubmed and EMBASE were searched from inception to November 2016 for English studies evaluating MRSA nasal screening and development of MRSA pneumonia...
January 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29339385/a-before-and-after-study-of-the-effectiveness-of-an-antimicrobial-stewardship-program-in-critical-care
#5
Francisco Álvarez-Lerma, Santiago Grau, Daniel Echeverría-Esnal, Montserrat Martínez-Alonso, María Pilar Gracia-Arnillas, Juan Pablo Horcajada, Juan Ramón Masclans
We evaluated the use of antimicrobials expressed as defined daily doses (DDDs) per 1,000 patient days and days of therapy (DOT) per 100 occupied bed-days in a intensive care unit (ICU) of a general hospital in Barcelona, Spain, before and after implementation of an antimicrobial stewardship (AMS) program (2007 to 2010 versus 2011 to 2015). The quarterly costs of antimicrobials used in the ICU and its weight in the overall hospital costs of antimicrobials were calculated. The effect of the applied AMS program on DDDs and DOT time series data was analyzed by means of intervention time series analysis...
April 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29299000/roles-of-infectious-diseases-consultant-pharmacists-and-antimicrobial-stewardship-pharmacists-a-survey-of-canadian-tertiary-care-academic-hospitals
#6
Jessica E Beach, Tasha D Ramsey, Sean K Gorman, Tim T Y Lau
Background: Infectious diseases consultant (IDC) pharmacists work within an IDC service to care for inpatients with complex infections. With Accreditation Canada's new Required Organizational Practice promoting the establishment of antimicrobial stewardship (AMS) programs, AMS pharmacists are being employed in acute care hospitals. There is potential for overlap in responsibilities between IDC and AMS pharmacists, but there is no literature outlining the current duties for each group in Canada...
November 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29274044/expanding-anticoagulation-management-services-to-include-direct-oral-anticoagulants
#7
REVIEW
Katelyn W Sylvester, Clara Ting, Andrea Lewin, Peter Collins, John Fanikos, Samuel Z Goldhaber, Jean M Connors
Despite the ease of use of direct oral anticoagulants (DOACs), these agents remain high risk medications and their clinical efficacy can be impacted by factors such as patient adherence, drug procurement barriers, bleeding leading to discontinuation, and prescribing that deviates from approved dosing regimens. Clinical monitoring of patients on DOACs should be performed by clinicians who specialize in anticoagulation and are familiar with the nuances of DOAC dosing, monitoring, and other components of anticoagulation management including peri-procedural management and care transitions...
February 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29132695/thai-clinicians-attitudes-toward-antimicrobial-stewardship-programs
#8
Nantanit Sutthiruk, Julie Considine, Ana Hutchinson, Andrea Driscoll, Kumthorn Malathum, Mari Botti
BACKGROUND: Effective hospital-wide antimicrobial stewardship (AMS) programs need multidisciplinary engagement; however, clinicians' attitudes have not been investigated in Thailand where AMS is in early development. The aim of this study was to explore Thai clinicians' (doctors, nurses, and pharmacists) perceptions and attitudes toward AMS. METHODS: A paper-based survey was distributed in a 1,000-bed university hospital in Bangkok, Thailand, between November 9, 2015, and December 21, 2015...
November 10, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29071048/changes-in-antimicrobial-prescribing-behavior-after-the-introduction-of-the-antimicrobial-stewardship-program-a-pre-and-post-intervention-survey
#9
Ruchir Chavada, Harry N Walker, Deborah Tong, Amy Murray
The introduction of an antimicrobial stewardship (AMS) program is associated with a change in antimicrobial prescribing behavior. A proposed mechanism for this change is by impacting the prescribing etiquette described in qualitative studies. This study sought to detect a change in prescribing attitudes 12 months after the introduction of AMS and gauge utility of various AMS interventions. Surveys were distributed to doctors in two regional Australian hospitals on a convenience basis 6 months before, and 12 months after, the introduction of AMS...
October 2, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28622926/hominid-visitation-of-the-moravian-karst-during-the-middle-upper-paleolithic-transition-new-results-from-pod-hradem-cave-czech-republic
#10
L Nejman, R Wood, D Wright, L Lisá, Z Nerudová, P Neruda, A Přichystal, J Svoboda
In 1956-1958, excavations of Pod Hradem Cave in Moravia (eastern Czech Republic) revealed evidence for human activity during the Middle-Upper Paleolithic transition. This spanned 25,050-44,800 cal BP and contained artefacts attributed to the Aurignacian and Szeletian cultures, including those made from porcelanite (rarely used at Moravian Paleolithic sites). Coarse grained excavation techniques and major inversions in radiocarbon dates meant that site chronology could not be established adequately. This paper documents re-excavation of Pod Hradem in 2011-2012...
July 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28608289/-antibiotic-stewardship-a-programmatic-approach-to-improved-antimicrobial-management
#11
REVIEW
Martin Müller, Patrick Lehmann, Christian Willy
Due to the increasing selection and prevalence of multidrug-resistant gram-negative bacteria and the insufficient development of novel antibiotics, the responsible and prudent use of the available antimicrobial drugs is of major importance. In Germany the rational use of anti-infectives considering the local antimicrobial resistance situation is defined in the infection protection act of 2011. An important tool to follow legal regulations and to improve the treatment of bacterial infections is the antimicrobial stewardship (AMS) concept...
July 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28539060/a-systematic-review-of-antimicrobial-stewardship-interventions-in-the-emergency-department
#12
REVIEW
Mia Losier, Tasha D Ramsey, Kyle John Wilby, Emily K Black
BACKGROUND/OBJECTIVE: To improve antimicrobial utilization, development and implementation of antimicrobial stewardship programs in the emergency department (ED) has been recommended. The primary objective of this review was to characterize antimicrobial stewardship (AMS) in the ED and to identify interventions that improve patient outcomes or process of care and/or reduce consequences of antimicrobial use. METHODS: This study was completed as a systematic review...
September 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28520865/impact-of-an-integrated-antibiotic-allergy-testing-program-on-antimicrobial-stewardship-a-multicenter-evaluation
#13
Jason A Trubiano, Karin A Thursky, Andrew J Stewardson, Karen Urbancic, Leon J Worth, Cheryl Jackson, Wendy Stevenson, Michael Sutherland, Monica A Slavin, M Lindsay Grayson, Elizabeth J Phillips
Background: Despite the high prevalence of patient-reported antibiotic allergy (so-called antibiotic allergy labels [AALs]) and their impact on antibiotic prescribing, incorporation of antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) is not widespread. We aimed to evaluate the impact of an AAT-AMS program on AAL prevalence, antibiotic usage, and appropriateness of prescribing. Methods: AAT-AMS was implemented at two large Australian hospitals during a 14-month period beginning May 2015...
July 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28463922/ultrasound-screening-for-posterior-shoulder-dislocation-in-infants-with-persistent-brachial-plexus-birth-palsy
#14
Andrea S Bauer, Justin F Lucas, Nasser Heyrani, Ryan L Anderson, Leslie A Kalish, Michelle A James
BACKGROUND: Early detection of posterior shoulder dislocation in infants with brachial plexus birth palsy (BPBP) is essential, but it may be difficult to accomplish with physical examination alone. The aim of this study was to determine the prevalence of shoulder dislocation in patients with BPBP using ultrasound and to identify which physical examination measurements correlated most with dislocation in these patients. METHODS: This study was a retrospective review of data obtained in an ultrasound screening program of infants with BPBP born from January 2011 to April 2014...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28424069/ankplex-algorithmic-structure-for-refinement-of-near-native-ankyrin-protein-docking
#15
Tanchanok Wisitponchai, Watshara Shoombuatong, Vannajan Sanghiran Lee, Kuntida Kitidee, Chatchai Tayapiwatana
BACKGROUND: Computational analysis of protein-protein interaction provided the crucial information to increase the binding affinity without a change in basic conformation. Several docking programs were used to predict the near-native poses of the protein-protein complex in 10 top-rankings. The universal criteria for discriminating the near-native pose are not available since there are several classes of recognition protein. Currently, the explicit criteria for identifying the near-native pose of ankyrin-protein complexes (APKs) have not been reported yet...
April 19, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28421818/cell-origin-dictates-programming-of-resident-versus-recruited-macrophages-during-acute-lung-injury
#16
Kara J Mould, Lea Barthel, Michael P Mohning, Stacey M Thomas, Alexandra L McCubbrey, Thomas Danhorn, Sonia M Leach, Tasha E Fingerlin, Brian P O'Connor, Julie A Reisz, Angelo D'Alessandro, Donna L Bratton, Claudia V Jakubzick, William J Janssen
Two populations of alveolar macrophages (AMs) coexist in the inflamed lung: resident AMs that arise during embryogenesis, and recruited AMs that originate postnatally from circulating monocytes. The objective of this study was to determine whether origin or environment dictates the transcriptional, metabolic, and functional programming of these two ontologically distinct populations over the time course of acute inflammation. RNA sequencing demonstrated marked transcriptional differences between resident and recruited AMs affecting three main areas: proliferation, inflammatory signaling, and metabolism...
September 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28012623/investigating-the-within-herd-prevalence-and-risk-factors-for-ketosis-in-dairy-cattle-in-ontario-as-diagnosed-by-the-test-day-concentration-of-%C3%AE-hydroxybutyrate-in-milk
#17
Elise H Tatone, Todd F Duffield, Stephen J LeBlanc, Trevor J DeVries, Jessica L Gordon
An observational study of 790 to over 3,000 herds was conducted to estimate the within-herd prevalence and cow-level risk factors for ketosis in dairy cattle in herds that participate in a Dairy Herd Improvement Association (DHIA) program. Ketosis or hyperketolactia (KET) was diagnosed as milk β-hydroxybutyrate ≥0.15 mmol/L at first DHIA test when tested within the first 30 d in milk. Seven hundred ninety-five herds providing at least 61 first milk tests from June 2014 to December 2015 were used to estimate the provincial within-herd prevalence of KET...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27994621/antimicrobial-stewardship-a-cross-sectional-survey-assessing-the-perceptions-and-practices-of-community-pharmacists-in-ethiopia
#18
Daniel Asfaw Erku
Background. Community pharmacists are key healthcare professionals for antimicrobial stewardship programs owing to their role in dispensing of antimicrobials. The aim of the present study was to assess the perception and practices of community pharmacists towards antimicrobial stewardship (AMS) in Ethiopia. Methods. A cross-sectional survey was conducted by selecting pharmacy sites through stratified simple random sampling technique. Descriptive and inferential statistics were used to analyze the data. Results...
2016: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/27986824/the-intersection-of-antimicrobial-stewardship-and-microbiology-educating-the-next-generation-of-health-care-professionals
#19
REVIEW
Lauren A O'Donnell, Anthony J Guarascio
With the alarming rise of antibiotic resistance, clinical professionals are called upon to manage antibiotic therapies using the most relevant and recent clinical and laboratory data. To this end, antimicrobial stewardship (AMS) programs aim to reduce unnecessary or suboptimal use of antibiotics while maximizing outcomes for the patient. For AMS programs to succeed, the active participation of clinical professionals at all levels of patient care is required. Although programs exist to train established clinicians in AMS, there is a paucity of literature on how and when to integrate AMS concepts and skills in pre-clinical and clinical coursework...
January 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27980377/temporal-trends-of-healthcare-associated-infections-and-antimicrobial-use-in-2011-2013-observed-with-annual-point-prevalence-surveys-in-ferrara-university-hospital-italy
#20
REVIEW
P Antonioli, M C Manzalini, A Stefanati, B Bonato, A Verzola, A Formaglio, G Gabutti
INTRODUCTION: Healthcare associated infections (HAIs) and misuse of antimicrobials (AMs) represent a growing public health problem. The Point Prevalence Surveys (PPSs) find available information to be used for specific targeted interventions and evaluate their effects. The objective of this study was to estimate the prevalence of HAIs and AM use, to describe types of infections, causative pathogens and to compare data collected through three PPSs in Ferrara University Hospital (FUH), repeated in 3 different years (2011-2013)...
September 2016: Journal of Preventive Medicine and Hygiene
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