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https://www.readbyqxmd.com/read/29327158/comparison-of-warfarin-requirements-in-post-cardiac-surgery-patients-valve-replacement-versus-non-valve-replacement
#1
Logan M Olson, Andrea M Nei, David L Joyce, Narith N Ou, Ross A Dierkhising, Scott D Nei
INTRODUCTION: Anticoagulation with warfarin affects approximately 140,000 post-cardiac surgery patients every year, yet there remains limited published data in this patient population. Dosing remains highly variable due to intrinsic risk factors that plague cardiac surgery candidates and a lack of diverse literature that can be applied to those who have undergone a cardiac surgery alternative to heart valve replacement (HVR). In the present study, our aim was to compare the warfarin requirements between HVR and non-HVR patients...
January 11, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29315424/cardiac-resynchronization-therapy-in-patients-with-end-stage-hypertrophic-cardiomyopathy
#2
Ammar M Killu, Jae-Yoon Park, Jaskanwal D Sara, David O Hodge, Bernard J Gersh, Rick A Nishimura, Samuel J Asirvatham, Christopher J McLeod
Aims: A dilated/end-stage phase of hypertrophic cardiomyopathy (HCM) is rare but well-recognized. The role for cardiac resynchronization therapy (CRT) in this subset of patients remains unexplored. We aimed to clarify the impact of bi-ventricular pacing CRT in dilated/end-stage HCM. Methods and results: The Mayo Clinic HCM database was interrogated to identify patients with ejection fraction (EF) <50% and CRT. Control subjects were identified in 1:1 manner...
January 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29299384/effect-of-early-hospital-readmission-and-comorbid-conditions-on-subsequent-long-term-mortality-after-transient-ischemic-attack
#3
Mohammed Yousufuddin, Nathan Young, Lawrence Keenan, Tammy Olson, Jessica Shultz, Taylor Doyle, Eimad Ahmmad, Kogulavadanan Arumaithurai, Paul Takahashi, Mohammad Hassan Murad
Background: The implications of early readmission on long-term mortality after transient ischemic attack (TIA) are not known. We aimed at examining the effect of 180-day readmission on subsequent long-term mortality after index hospitalization for TIA. Methods: A retrospective study of patients hospitalized for first-ever TIA at Mayo Clinic from 2000 through 2017. Patients readmitted within 180 days postdischarge were compared with those not readmitted in long-term risk of death...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29229372/invasive-and-noninvasive-hemodynamic-assessment-in-adults-with-fontan-palliation
#4
Alexander C Egbe, Heidi M Connolly, Nathaniel W Taggart, Mohamad Al-Otaibi, Barry A Borlaug
BACKGROUND/OBJECTIVES: Although echocardiographic-Doppler cardiac index (CI) assessment is widely used to guide heart failure management in patients with biventricular circulation, this application has not been studied in the Fontan population. The objective of this study was to: (1) determine the correlation between Doppler and cardiac catheterization CI calculation; (2) determine the association between Doppler CI and the occurrence of Fontan failure. METHODS: Retrospective review of adult Fontan patients followed at Mayo Clinic Adult Congenital Heart Disease program, 1994-2015...
December 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29223440/outcomes-of-cardiac-pacing-in-adult-patients-after-a-fontan-operation
#5
Alexander C Egbe, Geoffery D Huntley, Heidi M Connolly, Naser M Ammash, Abhishek J Deshmukh, Arooj R Khan, Sameh M Said, Emmanuel Akintoye, Carole A Warnes, Suraj Kapa
BACKGROUND: Cardiac pacing can be challenging after a Fontan operation, and limited data exist regarding pacing in adult Fontan patients. The objectives of our study were to determine risk factors for pacing and occurrence of device-related complications (DRCs) and pacemaker reinterventions. METHODS: We performed a retrospective review of Fontan patients from 1994 through 2014. We defined DRCs as lead failure, lead recall, cardiac perforation, lead thrombus/vegetation, or device-related infection, and cardiovascular adverse events (CAEs) as venous thrombosis, stroke, death, or heart transplant...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29221502/impact-of-cardiorespiratory-fitness-on-frequency-of-atrial-fibrillation-stroke-and-all-cause-mortality
#6
Nasir Hussain, Bernard J Gersh, Karina Gonzalez Carta, Nóra Sydó, Francisco Lopez-Jimenez, Stephen L Kopecky, Randal J Thomas, Samuel J Asirvatham, Thomas G Allison
Benefits of cardiorespiratory fitness on cardiovascular health are well recognized, but the impact on incidence of atrial fibrillation (AF) and stroke, and, particularly, risk of stroke and mortality in patients with AF is less clear. From 1993 to 2010, patients referred for a treadmill exercise test (TMET) at the Mayo Clinic Rochester, MN, were retrospectively identified (N = 76,857). From this, 14,094 local residents were selected. Exclusions were age <18 years; history of heart failure, structural or valvular heart disease, AF or flutter, or stroke...
January 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29208620/impact-of-electronic-clinical-decision-support-on-adherence-to-guideline-recommended-treatment-for-hyperlipidaemia-atrial-fibrillation-and-heart-failure-protocol-for-a-cluster-randomised-trial
#7
Maya Elizabeth Kessler, Rickey E Carter, David A Cook, Daryl Jon Kor, Paul M McKie, Laurie J Pencille, Marianne R Scheitel, Rajeev Chaudhry
INTRODUCTION: Clinical practice guidelines facilitate optimal clinical practice. Point of care access, interpretation and application of such guidelines, however, is inconsistent. Informatics-based tools may help clinicians apply guidelines more consistently. We have developed a novel clinical decision support tool that presents guideline-relevant information and actionable items to clinicians at the point of care. We aim to test whether this tool improves the management of hyperlipidaemia, atrial fibrillation and heart failure by primary care clinicians...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29191731/characteristic-morphologies-of-the-bicuspid-aortic-valve-in-patients-with-genetic-syndromes
#8
Talha Niaz, Joseph T Poterucha, Timothy M Olson, Jonathan N Johnson, Cecilia Craviari, Thomas Nienaber, Jared Palfreeman, Frank Cetta, Donald J Hagler
BACKGROUND: In patients with bicuspid aortic valve (BAV), complications including progressive aortic stenosis and aortic dilatation develop over time. The morphology of cusp fusion is one of the determinants of the type and severity of these complications. We present the association of morphology of cusp fusion in BAV patients with distinctive genetic syndromes. METHODS: The Mayo Clinic echocardiography database was retrospectively reviewed to identify patients (age ≤ 22 years) diagnosed with BAV from 1990 to 2016...
November 28, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29187090/outcomes-of-patients-with-familial-transthyretin-amyloidosis-after-liver-transplantation
#9
Dipti Banerjee, Lindsey E Roeker, Martha Grogan, Paul Swiecicki, John Poterucha, Julie Heimbach, Steve Zeldenrust, Morie Gertz, Brooks Edwards, Richard Daly, Kyle W Klarich, Angela Dispenzieri
BACKGROUND: Familial transthyretin amyloidosis is a disease caused by misfolded transthyretin aggregates that can impair multiple organ systems. Liver transplantation is the first-line treatment for familial transthyretin amyloidosis. RESEARCH QUESTION: Our objective is to study outcomes and survival among patients with familial transthyretin amyloidosis after transplantation. DESIGN: All patients undergoing orthotopic liver transplant for familial transthyretin amyloidosis at Mayo Clinic between 1997 and 2012 were reviewed...
September 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29171097/usefulness-of-left-ventricular-strain-analysis-in-patients-with-takotsubo-syndrome-during-acute-phase
#10
Andre Dias, Emiliana Franco, Manolo Rubio, Vikas Bhalla, Gregg S Pressman, Sarah Amanullah, Kathy Hebert, Vincent M Figueredo
BACKGROUND: Takotsubo syndrome (TTS) is peculiar clinical condition often resembling an acute coronary syndrome and mostly affecting postmenopausal women after a stressful trigger. TTS was initially thought to be a relatively benign condition. However, current data have shown it may be associated with considerable inpatient morbidity and carry a small, but important, mortality risk. METHODS: We hypothesized that left ventricular (LV) regional and global longitudinal strain (GLS) assessed with 2D speckle tracking echocardiography could identify early systolic functional impairment and predict in-hospital cardiovascular events...
November 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/29142540/clinical-audit-of-dengue-related-deaths-in-2011-mayo-hospital-lahore-pakistan
#11
Somia Iqtadar, Nabeel Akbar, Mehreen Mehmood, Sajid Abaidullah
Background and Objective: Dengue infection has evolved into an epidemic during last few years in Pakistan and has been associated with poor outcomes. Literature with respect to mortality risk factors in Dengue infection is not sufficient. This compelled us to conduct this study to find out major contributory factors to death in patients with dengue viral infection at one of Asia's ancient hospital setting with an aim to recognize complications at earliest and improve case management in future...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29095735/single-versus-multidrug-regimen-for-surgical-infection-prophylaxis-in-left-ventricular-assist-device-implantation
#12
Nana Aburjania, Brennan M Ertmer, Saira Farid, Melody Berg, Juhsien J C Nienaber, Vakhtang Tchantchaleishvili, John M Stulak, Muhammad R Sohail
Infection is a serious complication of left ventricular assist device (LVAD) therapy. However, an optimal antimicrobial surgical infection prophylaxis (SIP) regimen for LVAD implantation is not well established. We retrospectively reviewed all adults who underwent continuous-flow LVAD implantation from February 2007 to March 2015 at Mayo Clinic Rochester. Left ventricular assist device infection (LVADI) was defined using criteria published by the International Society for Heart and Lung Transplant. Patients excluded from the analysis included those who did not have HeartMate II or HeartWare device, patients with incomplete documentation of SIP, and those with an actively treated infection at the time of LVAD implantation...
October 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29064262/prognostic-comparison-between-creatinine-based-glomerular-filtration-rate-formulas-for-the-prediction-of-10-year-outcome-in-patients-with-non-st-elevation-acute-coronary-syndrome-treated-by-percutaneous-coronary-intervention
#13
Piercarlo Ballo, Tania Chechi, Gaia Spaziani, Veronica Fibbi, Duccio Conti, Giuseppe Ferro, Santi Nigrelli, Pietro Dattolo, Antonio Fazi, Giovanni Maria Santoro, Alfredo Zuppiroli, Francesco Pizzarelli
BACKGROUND: Estimated glomerular filtration rate (eGFR) is a predictor of outcome among patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), but which estimation formula provides the best long-term risk stratification in this setting is still unclear. We compared the prognostic performance of four creatinine-based formulas for the prediction of 10-year outcome in a NSTE-ACS population treated by percutaneous coronary intervention. METHODS: In 222 NSTE-ACS patients submitted to percutaneous coronary intervention, eGFR was calculated using four formulas: Cockcroft-Gault, re-expressed modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-Epi), and Mayo-quadratic...
March 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29046320/mortality-and-cerebrovascular-events-following-heart-rhythm-disorder-management-procedures
#14
Justin Z Lee, Jayna Ling, Nancy N Diehl, David O Hodge, Deepak Padmanabhan, Ammar M Killu, Malini Madhavan, Peter A Noseworthy, Suraj Kapa, Christopher J McLeod, Yong-Mei Cha, Abhishek J Deshmukh, Komandoor Srivathsan, Fred M Kusumoto, Win-Kuang Shen, Paul A Friedman, Thomas M Munger, Samuel J Asirvatham, Douglas L Packer, Siva K Mulpuru
Background -Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular event (CVE) after heart rhythm disorder management (HRDM) procedures is an essential step for development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and characterize death and CVE (stroke or transient ischemic attack) after HRDM procedures over a 17-year period. Methods -We performed a retrospective cohort study of all patients undergoing HRDM procedures between January 2000 and November 2016 at the Mayo Clinic...
October 18, 2017: Circulation
https://www.readbyqxmd.com/read/29023983/age-vascular-health-and-alzheimer-disease-biomarkers-in-an-elderly-sample
#15
Prashanthi Vemuri, Timothy G Lesnick, Scott A Przybelski, David S Knopman, Val J Lowe, Jonathan Graff-Radford, Rosebud O Roberts, Michelle M Mielke, Mary M Machulda, Ronald C Petersen, Clifford R Jack
OBJECTIVE: To investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample. METHODS: We identified 430 individuals along the cognitive continuum aged >60 years with amyloid positron emission tomography (PET), tau PET, and magnetic resonance imaging (MRI) scans from the population-based Mayo Clinic Study of Aging. A subset of 329 individuals had fluorodeoxyglucose (FDG) PET. We ascertained presently existing cardiovascular and metabolic conditions (CMC) from health care records and used the summation of presence/absence of hypertension, hyperlipidemia, cardiac arrhythmias, coronary artery disease, congestive heart failure, diabetes mellitus, and stroke as a surrogate for vascular health...
November 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28979775/acute-kidney-injury-in-octogenarians-after-heart-valve-replacement-surgery-a-study-of-two-periods-over-the-last-decade
#16
Charat Thongprayoon, Wisit Cheungpasitporn, Jing Lin, Michael A Mao, Qi Qian
BACKGROUND: Data on postoperative acute kidney injury (AKI) in octogenarians are limited. This study examines the AKI occurrence and clinical impact in octogenarians following open-heart valve replacement surgery in two periods over the last 15 years. METHODS: A total of 452 consecutive octogenarians (non-kidney transplant and non-dialysis) who underwent heart valve replacement at the Mayo Clinic during the years 2011-13 (contemporary cohort) were examined. The results were compared with a comparable 209 consecutive octogenarians in 2002-03 (past cohort)...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28944173/hypertrophic-obstructive-cardiomyopathy-the-mayo-clinic-experience
#17
Kunal D Kotkar, Sameh M Said, Joseph A Dearani, Hartzell V Schaff
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by left ventricular hypertrophy in the absence of other etiologies. Clinical presentation may vary from asymptomatic to sudden cardiac death. Medical treatment is the first-line therapy for symptomatic patients. Extended left ventricular septal myectomy is the procedure of choice if medical treatment is unsuccessful or intolerable. MAYO CLINIC EXPERIENCE: More than 3,000 patients have had septal myectomy for HCM at the Mayo Clinic (MN, USA) from 1993 to 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28923551/cardiac-melanoma-retrospective-review-of-a-rare-disease-at-the-mayo-clinic-1988-2015
#18
Chung Sang Tse, Nicholas Tan, Dame Idossa, Roger Click
BACKGROUND: Melanoma metastasizing to the heart (cardiac melanoma) is a rare entity that has been described only in autopsy studies or isolated pre-mortem case reports. We aim to better characterize cardiac melanoma, and describe its presenting features, imaging findings, and disease course with a case series collected over nearly 30years. METHODS: We performed a retrospective review of all patients diagnosed with cardiac melanoma at the Mayo Clinic from 1988 to 2015...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28917680/effusive-constrictive-pericarditis-after-pericardiocentesis-incidence-associated-findings-and-natural-history
#19
Kye Hun Kim, William R Miranda, Larry J Sinak, Faisal F Syed, Rowlens M Melduni, Raul E Espinosa, Garvan C Kane, Jae K Oh
OBJECTIVES: This study sought to investigate the incidence, associated findings, and natural history of effusive-constrictive pericarditis (ECP) after pericardiocentesis. BACKGROUND: ECP is characterized by the coexistence of tense pericardial effusion and constriction of the heart by the visceral pericardium. Echocardiography is currently the main diagnostic tool in the assessment of pericardial disease, but limited data have been published on the incidence and prognosis of ECP diagnosed by echo-Doppler...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28884343/prognostic-impact-of-isolated-right-ventricular-dysfunction-in-sepsis-and-septic-shock-an-8-year-historical-cohort-study
#20
Saraschandra Vallabhajosyula, Mukesh Kumar, Govind Pandompatam, Ankit Sakhuja, Rahul Kashyap, Kianoush Kashani, Ognjen Gajic, Jeffrey B Geske, Jacob C Jentzer
BACKGROUND: Echocardiographic myocardial dysfunction is reported commonly in sepsis and septic shock, but there are limited data on sepsis-related right ventricular dysfunction. This study sought to evaluate the association of right ventricular dysfunction with clinical outcomes in patients with severe sepsis and septic shock. METHODS: Historical cohort study of adult patients admitted to all intensive care units at the Mayo Clinic from January 1, 2007 through December 31, 2014 for severe sepsis and septic shock, who had an echocardiogram performed within 72 h of admission...
September 7, 2017: Annals of Intensive Care
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