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https://www.readbyqxmd.com/read/28651169/anticancer-activity-of-hydroxy-and-sulfonamide-azobenzene-platinum-ii-complexes-in-cisplatin-resistant-ovarian-cancer-cells
#1
Katia G Samper, Sierra C Marker, Pau Bayón, Samantha N MacMillan, Ivan Keresztes, Òscar Palacios, Justin J Wilson
The syntheses of three platinum(II) complexes bearing sulfonamide- ( (E)-2-(4-methylphenylsulfonamido)-2',6'-difluoroazobenzene, HL1) and hydroxy-azo-2,6-difluorobenzene ((E)-2-((2,6-difluorophenyl)diazenyl)phenol, HL2) bidentate ligands is described. These complexes, [Pt(L1)(DMSO)Cl] (1), [Pt(L2)(DMSO)Cl] (2), and [Pt(L2)2] (3), were characterized by multinuclear NMR spectroscopy, mass spectrometry, and X-ray crystallography. Despite bearing azobenzene functional groups, none of the three complexes undergo photoisomerization...
June 17, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28651014/a-decade-of-haart-in-latin-america-long-term-outcomes-among-the-first-wave-of-hiv-patients-to-receive-combination-therapy
#2
Marcelo J Wolff, Mark J Giganti, Claudia P Cortes, Pedro Cahn, Beatriz Grinsztejn, Jean W Pape, Denis Padgett, Juan Sierra-Madero, Eduardo Gotuzzo, Stephany N Duda, Catherine C McGowan, Bryan E Shepherd
BACKGROUND: In Latin America, the first wave of HIV-infected patients initiated highly active antiretroviral therapy (HAART) 10 or more years ago. Characterizing their treatment experience and corresponding outcomes across a decade of HAART may yield insights relevant to the ongoing care of such patients and those initiating HAART more recently in similar clinical settings. METHODS: This retrospective study included adults initiating HAART before 2004 at 8 sites in Argentina, Brazil, Chile, Haiti, Honduras, and Mexico...
2017: PloS One
https://www.readbyqxmd.com/read/28650170/gold-i-catalyzed-cycloisomerization-dimerization-cascade-of-benzene-tethered-1-6-enynes
#3
Mónica Álvarez-Pérez, Maria Frutos Pastor, Alma Viso, Roberto Fernández de la Pradilla, Maria C De La Torre, Miguel A Sierra, Heinz Gornitzka, Catherine Hemmert
An unprecedented stereoselective domino reaction of 1,6-enynes with an aryl ring at C3-C4 in the presence of gold(I) catalysts at low temperature is described. This process involves a novel 5-exo-dig cycloisomerization-dimerization sequence to afford formal Diels-Alder adducts that undergo a smooth gold-catalyzed double bond migration at room temperature. In addition, the first examples of the gold mesoionic carbene mediated [2+2+2] cycloaddition of these enynes with benzaldehyde are reported.
June 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28649974/utility-of-sup-13-sup-c-methacetin-breath-test-in-predicting-long-term-survival-of-patients-with-decompensated-cirrhosis
#4
Segundo Moran, Aline Mina, Ximena Duque, Nayeli Ortiz-Olvera, Gustavo Rodríguez-Leal, Jose Sierra-Ramirez, Roberto Medina, Robertino Mera, Misael Uribe
The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the functional activity of the liver and the prediction of liver cirrhosis. Nevertheless, there is no information on its potential utility to predict long-term survival in patients with liver disease. Methods: Patients with cirrhosis were selected. All patients underwent a complete clinical assessment, standard biochemical tests, and 13C-MeBT at the beginning of the study. Death was recorded during the three years of follow-up...
June 26, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28649338/estimating-and-interpreting-migration-of-amazonian-forests-using-spatially-implicit-and-semi-explicit-neutral-models
#5
Edwin Pos, Juan Ernesto Guevara Andino, Daniel Sabatier, Jean-François Molino, Nigel Pitman, Hugo Mogollón, David Neill, Carlos Cerón, Gonzalo Rivas-Torres, Anthony Di Fiore, Raquel Thomas, Milton Tirado, Kenneth R Young, Ophelia Wang, Rodrigo Sierra, Roosevelt García-Villacorta, Roderick Zagt, Walter Palacios Cuenca, Milton Aulestia, Hans Ter Steege
With many sophisticated methods available for estimating migration, ecologists face the difficult decision of choosing for their specific line of work. Here we test and compare several methods, performing sanity and robustness tests, applying to large-scale data and discussing the results and interpretation. Five methods were selected to compare for their ability to estimate migration from spatially implicit and semi-explicit simulations based on three large-scale field datasets from South America (Guyana, Suriname, French Guiana and Ecuador)...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28649302/differential-predictors-of-dsm-5-ptsd-and-icd-11-complex-ptsd-among-african-american-women
#6
Abigail Powers, Negar Fani, Sierra Carter, Dorthie Cross, Marylene Cloitre, Bekh Bradley
Background: Complex posttraumatic stress disorder (CPTSD) is proposed for inclusion in the ICD-11 as a diagnosis distinct from posttraumatic stress disorder (PTSD), reflecting deficits in affective, self-concept, and relational domains. There remains significant controversy over whether CPTSD provides useful diagnostic information beyond PTSD and other comorbid conditions, such as depression or substance use disorders. Objective: The present study examined differences in psychiatric presentation for three groups: traumatized controls, DSM-5 PTSD subjects, and ICD-11 CPTSD subjects...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28649008/environmental-traditional-knowledge-in-a-natural-protected-area-as-the-basis-for-management-and-conservation-policies
#7
Juan Fernando Pío-León, Francisco Delgado-Vargas, Bernardo Murillo-Amador, José Luís León-de-la-Luz, Rito Vega-Aviña, Alejandra Nieto-Garibay, Miguel Córdoba-Matson, Alfredo Ortega-Rubio
Ethnobotany is an adequate tool to identify the most import wild edible plants used by local people and to develop strategies for its sustainable use and policy making. This research records the wild edible plants used by the inhabitants of the Sierra la Laguna Biosphere Reserve, in Mexico, and identified priority species for sustainable development. The employed quantitative approach included the application of a food-oriented index named Food Significance Index (FSI), which integrated cultural, agricultural and food parameters; moreover, it used multivariate analysis to identify priority edible species for use and/or conservation...
June 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28648215/erratum-to-renal-graft-survival-according-to-banff-2013-classification-in-indication-biopsies
#8
Carlos Arias-Cabrales, Dolores Redondo-Pachón, María José Pérez-Sáez, Javier Gimeno, Ignacio Sánchez-Güerri, Sheila Bermejo, Adriana Sierra, Carla Burballa, Marisa Mir, Marta Crespo, Julio Pascual
No abstract text is available yet for this article.
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28647618/genetic-and-ecological-processes-promoting-early-diversification-in-the-lowland-mesoamerican-bat-sturnira-parvidens-chiroptera-phyllostomidae
#9
Giovani Hernández-Canchola, Livia León-Paniagua
With 22 species, Sturnira is the most speciose genus of frugivorous Neotropical bats. Sturnira parvidens inhabits lowland tropical areas from Mexico to Central America. The elevation of this taxon to species level was recent, and discrepancies with respect to its geographic limits and phylogenetic position continue to exist. In order to identify genetic and ecological processes likely involved in the diversification and current distribution of S. parvidens, we evaluated relationships, researched phylogeographic and demographic history, and tested the divergence/conservatism of the climatic niche of this bat...
June 21, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28647305/impact-of-asthma-on-the-sexual-functioning-of-patients-a-case-control-study
#10
José Gregorio Soto Campos, Josefa Rojas Villegas, Alicia Padilla Galo, Nuria Marina Malanda, Juan Luis Garcia Rivero, Celia Pinedo Sierra, Mercedes Garcia Salmones, Carmen Cabrera Galán, Esperanza Segura Molina, Vicente Plaza
INTRODUCTION: Sexual limitations play an important role in the quality of life of patients with chronic diseases. Very limited information is available on the impact of asthma on the sexual functioning of these individuals. MATERIALS AND METHODS: Cross-sectional, observational, multicenter study. Asthma patients and healthy individuals were recruited. All subjects participated in an interview in which demographic and clinical data were recorded, and completed the Goldberg Anxiety-Depression Scale (GADS) to evaluate the presence of concomitant psychiatric disease...
June 21, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28647042/transanal-endoscopic-microsurgery-for-the-treatment-of-uncommon-rectal-lesions
#11
Manuel Ferrer-Márquez, Francisco Rubio-Gil, Sofía Ortega-Ruiz, Isabel Blesa-Sierra, Antonio Álvarez-García, Jaime Jorge-Cerrudo, Elisabet Vidaña-Márquez, Ricardo Belda-Lozano, Ángel Reina-Duarte
INTRODUCTION: Transanal endoscopic microsurgery (TEM) was developed as a less aggressive alternative treatment for rectal lesions (mainly adenomas and adenocarcinomas). However, its use for other rectal lesions has become more frequent, trying to reduce the morbidity associated with more invasive techniques. The aim of this study is to describe our experience in the use of TEM in other rectal lesions. METHODS: Retrospective and descriptive study including patients operated with TEM (from June 2008 to December 2016) for the treatment of rectal lesions different from adenomas or adenocarcinomas...
June 21, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28646526/adamts13-test-and-or-plasmic-clinical-score-in-management-of-acquired-thrombotic-thrombocytopenic-purpura-a-cost-effective-analysis
#12
Chong H Kim, Sierra C Simmons, Lance A Williams Iii, Elizabeth M Staley, X Long Zheng, Huy P Pham
BACKGROUND: The ADAMTS13 test distinguishes thrombotic thrombocytopenic purpura (TTP) from other thrombotic microangiopathies (TMAs). The PLASMIC score helps determine the pretest probability of ADAMTS13 deficiency. Due to inherent limitations of both tests, and potential adverse effects and cost of unnecessary treatments, we performed a cost-effectiveness analysis (CEA) investigating the benefits of incorporating an in-hospital ADAMTS13 test and/or PLASMIC score into our clinical practice...
June 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28644114/midostaurin-plus-chemotherapy-for-acute-myeloid-leukemia-with-a-flt3-mutation
#13
Richard M Stone, Sumithra J Mandrekar, Ben L Sanford, Kristina Laumann, Susan Geyer, Clara D Bloomfield, Christian Thiede, Thomas W Prior, Konstanze Döhner, Guido Marcucci, Francesco Lo-Coco, Rebecca B Klisovic, Andrew Wei, Jorge Sierra, Miguel A Sanz, Joseph M Brandwein, Theo de Witte, Dietger Niederwieser, Frederick R Appelbaum, Bruno C Medeiros, Martin S Tallman, Jürgen Krauter, Richard F Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Richard A Larson, Hartmut Döhner
Background Patients with acute myeloid leukemia (AML) and a FLT3 mutation have poor outcomes. We conducted a phase 3 trial to determine whether the addition of midostaurin - an oral multitargeted kinase inhibitor that is active in patients with a FLT3 mutation - to standard chemotherapy would prolong overall survival in this population. Methods We screened 3277 patients, 18 to 59 years of age, who had newly diagnosed AML for FLT3 mutations. Patients were randomly assigned to receive standard chemotherapy (induction therapy with daunorubicin and cytarabine and consolidation therapy with high-dose cytarabine) plus either midostaurin or placebo; those who were in remission after consolidation therapy entered a maintenance phase in which they received either midostaurin or placebo...
June 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28643278/health-risks-of-environmental-exposure-to-metals-and-herbicides-in-the-pardo-river-brazil
#14
Carolina S Machado, Brisa M Fregonesi, Renato I S Alves, Karina A A Tonani, Jordi Sierra, Bruno S Martinis, Beatriz S Celere, Montse Mari, Marta Schuhmacher, Martí Nadal, Jose L Domingo, Susana Segura-Muñoz
Mixture of metals and herbicides in rivers may pose relevant risks for the health of surrounding communities. Humans may be exposed to river pollution through intake of contaminated water and fish, as well as irrigated agricultural products. The aim of this study was to assess the human health risks of environmental exposure to metals and herbicides through water and fish intake in the Pardo River. Metals (Al, As, Be, Cd, Cr, Cu, Pb, Mn, Hg, Ni, Tl, Sn, V, and Zn) were analyzed in river water and in edible fish...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28641224/elemental-copper-nanoparticle-toxicity-to-anaerobic-ammonium-oxidation-and-the-influence-of-ethylene-diamine-tetra-acetic-acid-edta-on-copper-toxicity
#15
Jorge Gonzalez-Estrella, Guangbin Li, Sarah E Neely, Daniel Puyol, Reyes Sierra-Alvarez, Jim A Field
Soluble ions released by elemental copper nanoparticles (Cu(0) NP) are toxic to key microorganisms of wastewater treatment processes. However, their toxicity to anaerobic ammonium oxidation (anammox) has not yet been studied. Chelating agents occurring in wastewater may decrease copper ions (Cu(2+)) concentration and consequently, decrease copper toxicity. This study evaluated Cu(0) NP and CuCl2 toxicity to anammox and the influence of ethylene diamine-tetra acetic acid (EDTA) on copper toxicity. Bioassays were supplemented with Cu(0) NP or CuCl2 with and without EDTA...
June 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28640823/estimating-the-number-of-secondary-ebola-cases-resulting-from-an-unsafe-burial-and-risk-factors-for-transmission-during-the-west-africa-ebola-epidemic
#16
Amanda Tiffany, Benjamin D Dalziel, Hilary Kagume Njenge, Ginger Johnson, Roselyn Nugba Ballah, Daniel James, Abdoulaye Wone, Juliet Bedford, Amanda McClelland
BACKGROUND: Safely burying Ebola infected individuals is acknowledged to be important for controlling Ebola epidemics and was a major component of the 2013-2016 West Africa Ebola response. Yet, in order to understand the impact of safe burial programs it is necessary to elucidate the role of unsafe burials in sustaining chains of Ebola transmission and how the risk posed by activities surrounding unsafe burials, including care provided at home prior to death, vary with human behavior and geography...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28640819/the-importance-of-data-quality-for-generating-reliable-distribution-models-for-rare-elusive-and-cryptic-species
#17
Keith B Aubry, Catherine M Raley, Kevin S McKelvey
The availability of spatially referenced environmental data and species occurrence records in online databases enable practitioners to easily generate species distribution models (SDMs) for a broad array of taxa. Such databases often include occurrence records of unknown reliability, yet little information is available on the influence of data quality on SDMs generated for rare, elusive, and cryptic species that are prone to misidentification in the field. We investigated this question for the fisher (Pekania pennanti), a forest carnivore of conservation concern in the Pacific States that is often confused with the more common Pacific marten (Martes caurina)...
2017: PloS One
https://www.readbyqxmd.com/read/28639454/the-role-of-cardiac-mri-in-cardio-oncology
#18
Juan Lopez-Mattei, Cezar Iliescu, Jean Bernard Durand, Saamir Hassan, Peter Kim, Lilia Sierra-Galan, Greg Gladish
No abstract text is available yet for this article.
June 22, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28638631/crystal-structures-of-three-n-3-acetyl-phen-yl-quinoline-2-carboxamides
#19
Diana Peña-Solórzano, Burkhard König, Cesar A Sierra, Cristian Ochoa-Puentes
In the title compounds, N-(5-acetyl-2-methyl-phen-yl)quinoline-2-carboxamide [C19H16N2O2, (I)], N-(5-acetyl-2-bromo-phen-yl)quinoline-2-carboxamide [C18H13BrN2O2, (II)] and N-(5-acetyl-2-ethynylphen-yl)quinoline-2-carboxamide [C20H14N2O2, (III)], the quinoline ring system is essentially planar and forms a dihedral angles of 3.68 (5) (I), 5.59 (7) (II) and 1.87 (6)° (III) with the acetyl-substituted ring. The mol-ecular structures of (I) and (III) each feature an intra-molecular N-H⋯N hydrogen bond, forming an S(5) ring, while in (II) an intra-molecular bifurcated N-H⋯(N,Br) hydrogen bond forms two S(5) rings...
June 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28637861/epidemic-and-endemic-pathogen-dynamics-correspond-to-distinct-host-population-microbiomes-at-a-landscape-scale
#20
Andrea J Jani, Roland A Knapp, Cheryl J Briggs
Infectious diseases have serious impacts on human and wildlife populations, but the effects of a disease can vary, even among individuals or populations of the same host species. Identifying the reasons for this variation is key to understanding disease dynamics and mitigating infectious disease impacts, but disentangling cause and correlation during natural outbreaks is extremely challenging. This study aims to understand associations between symbiotic bacterial communities and an infectious disease, and examines multiple host populations before or after pathogen invasion to infer likely causal links...
June 28, 2017: Proceedings. Biological Sciences
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