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https://www.readbyqxmd.com/read/29785884/morphological-changes-and-myocardial-function-assessed-by-traditional-and-novel-echocardiographic-methods-in-preadolescent-athlete-s-heart
#1
Anders W Bjerring, Hege Ew Landgraff, Svein Leirstein, Anette Aaeng, Hamza Z Ansari, Jørg Saberniak, Klaus Murbræch, Henrik Bruun, Thomas M Stokke, Kristina H Haugaa, Jostein Hallén, Thor Edvardsen, Sebastian I Sarvari
Background Athlete's heart is a term used to describe the morphological and functional changes in the hearts of athletes. Recent studies suggest that these changes may occur even in preadolescent athletes. This study aims to improve our understanding of the changes occurring in the preadolescent athlete's heart. Design and methods Cardiac morphology and function in 76 preadolescent cross-country skiers (aged 12.1 ± 0.2 years) were compared with 25 age-matched non-competing preadolescents. Echocardiography was performed in all subjects, including 2D speckle-tracking strain echocardiography and 3D echocardiography...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29785446/digital-droplet-pcr-based-absolute-quantification-of-pre-transplant-npm1-mutation-burden-predicts-relapse-in-acute-myeloid-leukemia-patients
#2
Marius Bill, Juliane Grimm, Madlen Jentzsch, Laura Kloss, Karoline Goldmann, Julia Schulz, Stefanie Beinicke, Janine Häntschel, Michael Cross, Vladan Vucinic, Wolfram Pönisch, Gerhard Behre, Georg-Nikolaus Franke, Thoralf Lange, Dietger Niederwieser, Sebastian Schwind
Allogeneic hematopoietic stem cell transplantation is an established consolidation therapy for patients with acute myeloid leukemia. However, relapse after transplantation remains a major clinical problem resulting in poor prognosis. Thus, detection of measurable ("minimal") residual disease to identify patients at high risk of relapse is essential. A feasible method to determine measurable residual disease may be digital droplet PCR (ddPCR) that allows absolute quantification with high sensitivity and specificity without the necessity of standard curves...
May 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29785221/cocrmo-alloy-vs-uhmwpe-particulate-implant-debris-induces-sex-dependent-aseptic-osteolysis-responses-in-vivo-using-a-murine-model
#3
Stefan Landgraeber, Lauryn Samelko, Kyron McAllister, Sebastian Putz, Joshua J Jacobs, Nadim James Hallab
Background: The rate of revision for some designs of total hip replacements due to idiopathic aseptic loosening has been reported as higher for women. However, whether this is environmental or inherently sex-related is not clear. Objective: Can particle induced osteolysis be sex dependent? And if so, is this dependent on the type of implant debris ( e.g . metal vs polymer)? The objective of this study was to test for material dependent inflammatory osteolysis that may be linked to sex using CoCrMo and implant grade conventional polyethylene (UHMWPE), using an in vivo murine calvaria model...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29785028/the-reference-epigenome-and-regulatory-chromatin-landscape-of-chronic-lymphocytic-leukemia
#4
Renée Beekman, Vicente Chapaprieta, Núria Russiñol, Roser Vilarrasa-Blasi, Núria Verdaguer-Dot, Joost H A Martens, Martí Duran-Ferrer, Marta Kulis, François Serra, Biola M Javierre, Steven W Wingett, Guillem Clot, Ana C Queirós, Giancarlo Castellano, Julie Blanc, Marta Gut, Angelika Merkel, Simon Heath, Anna Vlasova, Sebastian Ullrich, Emilio Palumbo, Anna Enjuanes, David Martín-García, Sílvia Beà, Magda Pinyol, Marta Aymerich, Romina Royo, Montserrat Puiggros, David Torrents, Avik Datta, Ernesto Lowy, Myrto Kostadima, Maša Roller, Laura Clarke, Paul Flicek, Xabier Agirre, Felipe Prosper, Tycho Baumann, Julio Delgado, Armando López-Guillermo, Peter Fraser, Marie-Laure Yaspo, Roderic Guigó, Reiner Siebert, Marc A Martí-Renom, Xose S Puente, Carlos López-Otín, Ivo Gut, Hendrik G Stunnenberg, Elias Campo, Jose I Martin-Subero
Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which underlying epigenetic alterations are only partially understood. Here, we analyze the reference epigenome of seven primary CLLs and the regulatory chromatin landscape of 107 primary cases in the context of normal B cell differentiation. We identify that the CLL chromatin landscape is largely influenced by distinct dynamics during normal B cell maturation. Beyond this, we define extensive catalogues of regulatory elements de novo reprogrammed in CLL as a whole and in its major clinico-biological subtypes classified by IGHV somatic hypermutation levels...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29784957/metabolic-reprogramming-in-leaf-lettuce-grown-under-different-light-quality-and-intensity-conditions-using-narrow-band-leds
#5
Kazuyoshi Kitazaki, Atsushi Fukushima, Ryo Nakabayashi, Yozo Okazaki, Makoto Kobayashi, Tetsuya Mori, Tomoko Nishizawa, Sebastian Reyes-Chin-Wo, Richard W Michelmore, Kazuki Saito, Kazuhiro Shoji, Miyako Kusano
Light-emitting diodes (LEDs) are an artificial light source used in closed-type plant factories and provide a promising solution for a year-round supply of green leafy vegetables, such as lettuce (Lactuca sativa L.). Obtaining high-quality seedlings using controlled irradiation from LEDs is critical, as the seedling health affects the growth and yield of leaf lettuce after transplantation. Because key molecular pathways underlying plant responses to a specific light quality and intensity remain poorly characterised, we used a multi-omics-based approach to evaluate the metabolic and transcriptional reprogramming of leaf lettuce seedlings grown under narrow-band LED lighting...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29783948/expansion-of-the-sos-regulon-of-vibrio-cholerae-through-extensive-transcriptome-analysis-and-experimental-validation
#6
Evelyne Krin, Sebastian Aguilar Pierlé, Odile Sismeiro, Bernd Jagla, Marie-Agnès Dillies, Hugo Varet, Oihane Irazoki, Susana Campoy, Zoé Rouy, Stéphane Cruveiller, Claudine Médigue, Jean-Yves Coppée, Didier Mazel
BACKGROUND: The SOS response is an almost ubiquitous response of cells to genotoxic stresses. The full complement of genes in the SOS regulon for Vibrio species has only been addressed through bioinformatic analyses predicting LexA binding box consensus and in vitro validation. Here, we perform whole transcriptome sequencing from Vibrio cholerae treated with mitomycin C as an SOS inducer to characterize the SOS regulon and other pathways affected by this treatment. RESULTS: Comprehensive transcriptional profiling allowed us to define the full landscape of promoters and transcripts active in V...
May 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29783887/a-vision-for-global-heath-diplomacy-in-the-foreign-policy-process-using-smart-power-to-prevent-and-resolve-international-conflict
#7
Sebastian Kevany
In the twenty-first Century, the developed world attempts to provide global health assistance, to poorer countries - at least in part in the pursuit and maintenance of world order and stability. Rarely, however - and in most cases, then on an ad hoc basis - are related foreign policy tools deployed in combination with each other. Nonetheless, there is currently greater openness than ever before to such interdigitation. Not least this reflects the unprecedented challenges of modern political and security conditions - struggling to operate amidst a broader culture of global adverserialism, and conflict which conventional systems of intervention have struggled to successfully resolve...
May 21, 2018: Global Public Health
https://www.readbyqxmd.com/read/29783655/gdf11-modulates-ca-2-dependent-smad2-3-signaling-to-prevent-cardiomyocyte-hypertrophy
#8
Javier Duran, Mayarling Francisca Troncoso, Daniel Lagos, Sebastian Ramos, Gabriel Marin, Manuel Estrada
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca2+ signaling modulates cardiomyocyte growth; however, the role of Ca2+ -dependent mechanisms in mediating the effects of GDF11 remains elusive. Here, we found that GDF11 induced intracellular Ca2+ increases in neonatal rat cardiomyocytes and that this response was blocked by chelating the intracellular Ca2+ with BAPTA-AM or by pretreatment with inhibitors of the inositol 1,4,5-trisphosphate (IP₃) pathway...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29783156/transient-impairment-of-olfactory-threshold-in-acute-multiple-sclerosis-relapse
#9
Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Andreas Lutterotti, Thomas Berger
BACKGROUND: Impairment of olfactory threshold is a feature of early and active relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease activity and was reported to be transient. However, the timing of onset and resolve of olfactory threshold impairment remains unclear. OBJECTIVE: To prospectively assess the development of olfactory threshold in acute MS relapse over time in comparison to stable MS patients. METHODS: In a prospective observational design, we measured olfactory threshold by performing the Sniffin' Sticks test (minimum score 0, maximum score 16 reflecting optimal olfactory function) at baseline and after 4, 12 and 24 weeks...
May 18, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29782949/early-detection-of-pancreatic-cancers-in-liquid-biopsies-by-ultrasensitive-fluorescence-nanobiosensors
#10
Madumali Kalubowilage, Obdulia Covarrubias-Zambrano, Aruni P Malalasekera, Sebastian O Wendel, Hongwang Wang, Asanka S Yapa, Lauren Chlebanowski, Yubisela Toledo, Raquel Ortega, Katharine E Janik, Tej B Shrestha, Christopher T Culbertson, Anup Kasi, Stephen Williamson, Deryl L Troyer, Stefan H Bossmann
Numerous proteases, such as matrix metalloproteinases (MMP's), cathepsins (CTS), and urokinase plasminogen activator (UpA), are dysfunctional (that is, over- or under-expressed) in solid tumors, when compared to healthy human subjects. This offers the opportunity to detect early tumors by liquid biopsies. This approach is of particular advantage for the early detection of pancreatic cancer, which is a "silent killer". We have developed fluorescence nanobiosensors for ultrasensitive (sub-femtomolar) arginase and protease detection, consisting of water-dispersible Fe/Fe3 O4 core/shell nanoparticles and two tethered fluorescent dyes: TCPP (Tetrakis(4-carboxyphenyl)porphyrin) and cyanine 5...
May 18, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29782503/impact-and-recovery-process-of-mini-flash-crashes-an-empirical-study
#11
Tobias Braun, Jonas A Fiegen, Daniel C Wagner, Sebastian M Krause, Thomas Guhr
In an Ultrafast Extreme Event (or Mini Flash Crash), the price of a traded stock increases or decreases strongly within milliseconds. We present a detailed study of Ultrafast Extreme Events in stock market data. In contrast to popular belief, our analysis suggests that most of the Ultrafast Extreme Events are not necessarily due to feedbacks in High Frequency Trading: In at least 60 percent of the observed Ultrafast Extreme Events, the largest fraction of the price change is due to a single market order. In times of financial crisis, large market orders are more likely which leads to a significant increase of Ultrafast Extreme Events occurrences...
2018: PloS One
https://www.readbyqxmd.com/read/29782488/insight-into-small-molecule-binding-to-the-neonatal-fc-receptor-by-x-ray-crystallography-and-100-khz-magic-angle-spinning-nmr
#12
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinning of the nondeuterated soluble 42 kDa receptor construct to obtain resolved proton-detected 2D and 3D NMR spectra. FcRn plays a crucial role in regulation of IgG and serum albumin catabolism. It is a clinically validated drug target for the treatment of autoimmune diseases caused by pathogenic antibodies via the inhibition of its interaction with IgG...
May 21, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29782427/clinical-profile-of-levamisole-adulterated-cocaine-induced-vasculitis-vasculopathy-a-30-case-series
#13
Carlos Horacio Muñoz-Vahos, Sebastián Herrera-Uribe, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González-Naranjo, Gloria Vásquez-Duque, Mauricio Restrepo-Escobar, Luis Alfonso Correa-Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García
OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29781651/exposure-and-cbt-for-chronic-back-pain-an-rct-on-differential-efficacy-and-optimal-length-of-treatment
#14
Julia Anna Glombiewski, Sebastian Holzapfel, Jenny Riecke, Johan W S Vlaeyen, Jeroen de Jong, Gunnar Lemmer, Winfried Rief
OBJECTIVE: Our aim was to establish whether Exposure, a specialized tailored treatment for chronic low back pain, has any advantages over cognitive-behavioral therapy (CBT) among individuals with high fear-avoidance levels. Second, we planned to compare short and long versions of Exposure. Third, we aimed to investigate whether Exposure can be delivered in an outpatient psychological setting. METHOD: A total of 88 Caucasian participants (55% women) were randomized to three different psychological treatment conditions, Exposure-long, Exposure-short, and CBT...
June 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29781041/a-bead-based-immunogold-silver-staining-assay-on-capillary-driven-microfluidics
#15
Ngoc M Pham, Sebastian Rusch, Yuksel Temiz, Robert D Lovchik, Hans-Peter Beck, Walter Karlen, Emmanuel Delamarche
Point-of-care (POC) diagnostics are critically needed for the detection of infectious diseases, particularly in remote settings where accurate and appropriate diagnosis can save lives. However, it is difficult to implement immunoassays, and specifically immunoassays relying on signal amplification using silver staining, into POC diagnostic devices. Effective immobilization of antibodies in such devices is another challenge. Here, we present strategies for immobilizing capture antibodies (cAbs) in capillary-driven microfluidic chips and implementing a gold-catalyzed silver staining reaction...
May 21, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29780859/monoaminergic-impairment-in-down-syndrome-with-alzheimer-s-disease-compared-to-early-onset-alzheimer-s-disease
#16
Alain D Dekker, Yannick Vermeiren, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Ellen Gelpi, Tony Aerts, Debby Van Dam, Susana Fernández, Alberto Lleó, Sebastian Videla, Anne Sieben, Jean-Jacques Martin, Rafael Blesa, Juan Fortea, Peter P De Deyn
Introduction: People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. Methods: Noradrenaline, adrenaline, and their metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG); dopamine and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid; and serotonin and its metabolite 5-hydroxyindoleacetic acid were quantified in 15 brain regions of DS without AD (DS, n = 4), DS with AD (DS+AD, n = 17), early-onset AD (EOAD, n = 11) patients, and healthy non-DS controls (n = 10) in the general population...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780710/can-we-use-interleukin-1%C3%AE-blockade-for-lung-cancer-treatment
#17
EDITORIAL
Adrian Gottschlich, Stefan Endres, Sebastian Kobold
No abstract text is available yet for this article.
April 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29780612/the-sound-of-jacqueline-du-pr%C3%A3-revisiting-her-medical-and-musical-history
#18
REVIEW
Luis Octavio Tierradentro-García, Juan Sebastián Botero-Meneses, Claudia Talero-Gutiérrez
Jacqueline du Pré was a British cellist, famous for her masterful interpretations and her passionate style of playing. Her outstanding musical career was, unfortunately, cut short by multiple sclerosis. In the present paper, we conduct a historical and medical analysis of her life story, discussing a few aspects regarding her illness and treatment options available at the time of her diagnosis.
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29780462/fluorescent-dyes-and-probes-for-super-resolution-microscopy-of-microtubules-and-tracheoles-in-living-cells-and-tissues
#19
Gražvydas Lukinavičius, Gyuzel Y Mitronova, Sebastian Schnorrenberg, Alexey N Butkevich, Hannah Barthel, Vladimir N Belov, Stefan W Hell
We introduce fluorogenic tubulin probes based on the recently reported fluorescent dyes (510R, 580CP, GeR and SiR) and chemotherapy agents - taxanes (docetaxel, cabazitaxel and larotaxel). The cytotoxicity of the final probe, its staining performance and specificity strongly depend on both components. We found correlation between the aggregation efficiency (related to the spirolactonization of fluorophore) and cytotoxicity. Probe optimization allowed us to reach 29 ± 11 nm resolution in stimulated emission depletion (STED) microscopy images of the microtubule network in living human fibroblasts...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779918/tracking-tumor-biology-with-radiomics-a-systematic-review-utilizing-a-radiomics-quality-score
#20
REVIEW
Sebastian Sanduleanu, Henry C Woodruff, Evelyn E C de Jong, Janna E van Timmeren, Arthur Jochems, Ludwig Dubois, Philippe Lambin
INTRODUCTION: In this review we describe recent developments in the field of radiomics along with current relevant literature linking it to tumor biology. We furthermore explore the methodologic quality of these studies with our in-house radiomics quality scoring (RQS) tool. Finally, we offer our vision on necessary future steps for the development of stable radiomic features and their links to tumor biology. METHODS: Two authors (S.S. and H.W.) independently performed a thorough systematic literature search and outcome extraction to identify relevant studies published in MEDLINE/PubMed (National Center for Biotechnology Information, NCBI), EMBASE (Ovid) and Web of Science (WoS)...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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