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https://www.readbyqxmd.com/read/29166667/flotillin-scaffold-activity-contributes-to-type-vii-secretion-system-assembly-in-staphylococcus-aureus
#1
Benjamin Mielich-Süss, Rabea M Wagner, Nicole Mietrach, Tobias Hertlein, Gabriella Marincola, Knut Ohlsen, Sebastian Geibel, Daniel Lopez
Scaffold proteins are ubiquitous chaperones that promote efficient interactions between partners of multi-enzymatic protein complexes; although they are well studied in eukaryotes, their role in prokaryotic systems is poorly understood. Bacterial membranes have functional membrane microdomains (FMM), a structure homologous to eukaryotic lipid rafts. Similar to their eukaryotic counterparts, bacterial FMM harbor a scaffold protein termed flotillin that is thought to promote interactions between proteins spatially confined to the FMM...
November 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29166545/occurrence-of-primarily-noninducible-atrioventricular-nodal-reentry-tachycardia-after-radiofrequency-delivery-in-the-slow-pathway-region-during-empirical-slow-pathway-modulation
#2
Felix Konrad Wegner, Nils Bögeholz, Patrick Leitz, Gerrit Frommeyer, Dirk Georg Dechering, Simon Kochhäuser, Philipp Sebastian Lange, Julia Köbe, Kristina Wasmer, Gerold Mönnig, Lars Eckardt, Christian Pott
BACKGROUND: The first-line therapy for atrioventricular nodal reentry tachycardia (AVNRT) is catheter-based slow pathway modulation. If AVNRT is not inducible during an electrophysiological study, an empirical slow pathway modulation (ESPM) may be considered in patients with dual atrioventricular nodal physiology and/or a typical electrocardiogram (ECG). METHODS: We screened 149 symptomatic patients who underwent ESPM in our department between 1993 and 2013. All patients fulfilled the following criteria: (1) either dual atrioventricular nodal (AVN) physiology with up to 2 AVN echo beats or characteristic ECG documentation or both, (2) noninducibility of AVNRT by programmed stimulation, and (3) completion of a telephone questionnaire for long-term follow-up...
November 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#3
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166416/limited-effect-of-cement-material-on-stress-distribution-of-a-monolithic-translucent-zirconia-crown-a-three-dimensional-finite-element-analysis
#4
Sebastian Franco-Tabares, Victoria Franke Stenport, Lars Hjalmarsson, Carina B Johansson
PURPOSE: The literature shows that the performance of densely sintered zirconia single crowns seems to be unaffected by the cement material. The purpose of this study was to evaluate the effects of various cement materials on the stress distribution in a monolithic translucent zirconia crown. MATERIALS AND METHODS: A crown-cement-dentin complex was modeled. Six cements were evaluated: zinc phosphate, glass-ionomer, resin-modified glass-ionomer, dual-cure resin, calcium aluminate-based, and a theoretical or conceptual cement with mechanical properties close to those of dentin (ie, monoblock cement)...
November 22, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29166032/combined-cononsolvency-and-temperature-effects-on-adsorbed-pnipam-microgels
#5
Sebastian Backes, Patrick Krause, Weronika Tabaka, Marcus U Witt, Regine von Klitzing
The present study adresses the multi-responsive behavior of Poly(N-isopropylacrylamide) (PNIPAM) microgels adsorbed to interfaces. The microgels react to changes in temperature by shrinking in aqueous solution above their volume phase transition temperature (VPTT). Additionally, they shrink in mixtures of water and ethanol, although both individual liquids are good solvents for PNIPAM. The combination of this so-called cononsolvency effect and the temperature response of adsorbed microgels is studied by atomic force microscopy (AFM)...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29165464/analytical-sers-general-discussion
#6
Hannah Aitchison, Javier Aizpurua, Heike Arnolds, Jeremy Baumberg, Steven Bell, Alois Bonifacio, Rohit Chikkaraddy, Paul Dawson, Bart de Nijs, Volker Deckert, Ines Delfino, Giuliana Di Martino, Olga Eremina, Karen Faulds, Augustus Fountain, Sylwester Gawinkowski, Mayte Gomez Castano, Roy Goodacre, Jennifer Gracie, Duncan Graham, Jason Guicheteau, Laurence Hardwick, Mike Hardy, Christian Heck, Lauren Jamieson, Marlous Kamp, Alex Keeler, Christian Kuttner, Judith Langer, Sumeet Mahajan, Natalia Martín Sabanés, Kei Murakoshi, Marc Porter, George Schatz, Sebastian Schlücker, Zhongqun Tian, Ashish Tripathi, Richard Van Duyne, Peter Vikesland
No abstract text is available yet for this article.
November 22, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/29165296/progressive-nodular-histiocytosis-improved-by-methotrexate
#7
Flavien Huet, Emilie Brenaut, Sebastian Costa, Gilles Lemasson, Haitham Sonbol, Laurent Misery
No abstract text is available yet for this article.
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29165246/regulatory-coiled-coil-domains-promote-head-to-head-assemblies-of-aaa-chaperones-essential-for-tunable-activity-control
#8
Marta Carroni, Kamila B Franke, Michael Maurer, Jasmin Jäger, Ingo Hantke, Felix Gloge, Daniela Linder, Sebastian Gremer, Kürşad Turgay, Bernd Bukau, Axel Mogk
Ring-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a central pore. This activity is potentially harmful requiring mechanisms for tight repression and substrate-specific activation. The AAA+ chaperone ClpC with the peptidase ClpP forms a bacterial protease essential to virulence and stress resistance. The adaptor MecA activates ClpC by targeting substrates and stimulating ClpC ATPase activity. We show how ClpC is repressed in its ground state by determining ClpC cryo-EM structures with and without MecA...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29164727/highly-efficient-synthesis-of-a-staphylococcus-aureus-targeting-payload-enabling-the-first-antibody-antibiotic-conjugate
#9
Xin Linghu, Nathaniel Segraves, Ifat Abramovich, Nicholas Wong, Barbara Müller, Nadja Neubauer, Serena Fantasia, Sebastian Rieth, Stephan Bachmann, Michael Jansen, C Gregory Sowell, David Askin, Stefan Koenig, Francis Gosselin
A practical synthesis of the complex payload for an anti-Staphylococcus aureus THIOMAB TM antibody-antibiotic conjugate (TAC) is described. The route takes advantage of a delicate oxidative condensation, achieved via a semi-continuous flow procedure. It allows for the generation of kilogram quantities of a key intermediate to enable a mild nucleophilic aromatic substitution to the tertiary amine free drug. The linker component is introduced as a benzylic chloride, which allows formation of the quaternary ammonium salt linker-drug...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29164208/-unknown-title
#10
Jia Wang, Philip H Chao, Sebastian Hanet, R Michael van Dam
Despite the increasing importance of positron emission tomography (PET) imaging in research and clinical management of disease, access to myriad new radioactive tracers is severely limited due to their short half-lives (which requires daily production) and the high cost and complexity of tracer production. The application of droplet microfluidics based on electrowetting-on-dielectric (EWOD) to the field of radiochemistry can significantly reduce the amount of radiation shielding necessary for safety and the amount of precursor and other reagents needed for the synthesis...
November 22, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29164205/theory-of-sers-enhancement-general-discussion
#11
Duncan Graham, Roy Goodacre, Heike Arnolds, Jean-Francois Masson, George Schatz, Jeremy Baumberg, Dong-Ho Kim, Javier Aizpurua, William Lum, Alessandro Silvestri, Bart de Nijs, Yikai Xu, Giuliana Di Martino, Michael Natan, Sebastian Schlücker, Pieter Wuytens, Ian Bruzas, Christian Kuttner, Mike Hardy, Rohit Chikkaraddy, Natalia Martín Sabanés, Ines Delfino, Paul Dawson, Sylwester Gawinkowski, Nicolò Bontempi, Sumeet Mahajan, Stephanie Reich, Ben Hourahine, Steven Bell, Agata Królikowska, Marc Porter, Alex Keeler, Marlous Kamp, Augustus Fountain, Claudia Fasolato, Fabrizio Giorgis, Juan C Otero, Cristiano Matricardi, Richard Van Duyne, John Lombardi, Volker Deckert, Leonora Velleman
No abstract text is available yet for this article.
November 22, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/29163867/strengthening-mental-health-care-systems-for-syrian-refugees-in-europe-and-the-middle-east-integrating-scalable-psychological-interventions-in-eight-countries
#12
REVIEW
Marit Sijbrandij, Ceren Acarturk, Martha Bird, Richard A Bryant, Sebastian Burchert, Kenneth Carswell, Joop de Jong, Cecilie Dinesen, Katie S Dawson, Rabih El Chammay, Linde van Ittersum, Mark Jordans, Christine Knaevelsrud, David McDaid, Kenneth Miller, Naser Morina, A-La Park, Bayard Roberts, Yvette van Son, Egbert Sondorp, Monique C Pfaltz, Leontien Ruttenberg, Matthis Schick, Ulrich Schnyder, Mark van Ommeren, Peter Ventevogel, Inka Weissbecker, Erica Weitz, Nana Wiedemann, Claire Whitney, Pim Cuijpers
The crisis in Syria has resulted in vast numbers of refugees seeking asylum in Syria's neighbouring countries as well as in Europe. Refugees are at considerable risk of developing common mental disorders, including depression, anxiety, and posttraumatic stress disorder (PTSD). Most refugees do not have access to mental health services for these problems because of multiple barriers in national and refugee specific health systems, including limited availability of mental health professionals. To counter some of challenges arising from limited mental health system capacity the World Health Organization (WHO) has developed a range of scalable psychological interventions aimed at reducing psychological distress and improving functioning in people living in communities affected by adversity...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29163418/pharmacodynamics-pharmacokinetics-and-antiviral-activity-of-bay-81-8781-a-novel-nf-%C3%AE%C2%BAb-inhibiting-anti-influenza-drug
#13
Karoline Droebner, Emanuel Haasbach, Sabine E Dudek, Gerhard Scheuch, Karlheinz Nocker, Sebastian Canisius, Christina Ehrhardt, Georges von Degenfeld, Stephan Ludwig, Oliver Planz
Influenza is a respiratory disease that causes annual epidemics. Antiviral treatment options targeting the virus exist, but their efficiency is limited and influenza virus strains easily develop resistance. Thus, new treatment strategies are urgently needed. In the present study, we investigated the anti-influenza virus properties of D,L-lysine acetylsalicylate ⋅ glycine (BAY 81-8781; LASAG) that is approved as Aspirin i.v. for intravenous application. Instead of targeting the virus directly BAY 81-8781 inhibits the activation of the NF-κB pathway, which is required for efficient influenza virus propagation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163299/behavioral-evidence-for-enhanced-processing-of-the-minor-component-of-binary-odor-mixtures-in-larval-drosophila
#14
Yi-Chun Chen, Dushyant Mishra, Sebastian Gläß, Bertram Gerber
A fundamental problem in deciding between mutually exclusive options is that the decision needs to be categorical although the properties of the options often differ but in grade. We developed an experimental handle to study this aspect of behavior organization. Larval Drosophila were trained such that in one set of animals odor A was rewarded, but odor B was not (A+/B), whereas a second set of animals was trained reciprocally (A/B+). We then measured the preference of the larvae either for A, or for B, or for "morphed" mixtures of A and B, that is for mixtures differing in the ratio of the two components...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163257/free-will-and-the-brain-disease-model-of-addiction-the-not-so-seductive-allure-of-neuroscience-and-its-modest-impact-on-the-attribution-of-free-will-to-people-with-an-addiction
#15
Eric Racine, Sebastian Sattler, Alice Escande
Free will has been the object of debate in the context of addiction given that addiction could compromise an individual's ability to choose freely between alternative courses of action. Proponents of the brain-disease model of addiction have argued that a neuroscience perspective on addiction reduces the attribution of free will because it relocates the cause of the disorder to the brain rather than to the person, thereby diminishing the blame attributed to the person with an addiction. Others have worried that such displacement of free will attribution would make the person with a drug addiction less responsible...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29162815/organic-carbon-burial-in-global-lakes-and-reservoirs
#16
Raquel Mendonça, Roger A Müller, David Clow, Charles Verpoorter, Peter Raymond, Lars J Tranvik, Sebastian Sobek
Burial in sediments removes organic carbon (OC) from the short-term biosphere-atmosphere carbon (C) cycle, and therefore prevents greenhouse gas production in natural systems. Although OC burial in lakes and reservoirs is faster than in the ocean, the magnitude of inland water OC burial is not well constrained. Here we generate the first global-scale and regionally resolved estimate of modern OC burial in lakes and reservoirs, deriving from a comprehensive compilation of literature data. We coupled statistical models to inland water area inventories to estimate a yearly OC burial of 0...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162810/dna-methylation-signatures-follow-preformed-chromatin-compartments-in-cardiac-myocytes
#17
Stephan Nothjunge, Thomas G Nührenberg, Björn A Grüning, Stefanie A Doppler, Sebastian Preissl, Martin Schwaderer, Carolin Rommel, Markus Krane, Lutz Hein, Ralf Gilsbach
Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers of chromatin organization and epigenetic control mechanisms exist. Genome-wide chromatin interaction maps revealed large interaction domains (TADs) and higher order A and B compartments, reflecting active and inactive chromatin, respectively. The mutual dependencies between chromatin organization and patterns of epigenetic marks, including DNA methylation, remain poorly understood...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162741/nuclear-hyaluronidase-2-drives-alternative-splicing-of-cd44-pre-mrna-to-determine-profibrotic-or-antifibrotic-cell-phenotype
#18
Adam C Midgley, Sebastian Oltean, Vincent Hascall, Emma L Woods, Robert Steadman, Aled O Phillips, Soma Meran
The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis. The diversity of CD44 biological activity is partly conferred by the generation of distinct CD44 isoforms through alternative splicing. We identified an unexpected function for the ubiquitous hyaluronan-degrading enzyme, hyaluronidase 2 (HYAL2), as a regulator of CD44 splicing. Standard CD44 is associated with fibrotic disease, and its production is promoted through serine-arginine-rich (SR) protein-mediated exon exclusion...
November 21, 2017: Science Signaling
https://www.readbyqxmd.com/read/29162464/biochemical-and-biophysical-characterization-of-curcumin-binding-to-human-mitotic-kinesin-eg5-iinsights-into-the-inhibitory-mechanism-of-curcumin-on-eg5
#19
Darpan Raghav, Jomon Sebastian, Krishnan Rathinasamy
In this study we have characterized the biochemical and biophysical interactions of curcumin with the mitotic kinesin Eg5 which plays a pivotal role in the separation of centrosomes during cell division. Curcumin bound to the purified Eg5 (Eg5-437H) with a Kd value of 7.8mM. The temperature dependent binding analysis and evaluation of thermodynamic parameters indicated the involvement of static quenching mechanism in the binding process. Evidences from competition experiment with monastrol indicated that curcumin bound to Eg5 at a novel druggable site...
November 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29162190/early-life-stress-fk506-binding-protein-5-gene-fkbp5-methylation-and-inhibition-related-prefrontal-function-a-prospective-longitudinal-study
#20
Madeline B Harms, Rasmus Birn, Nadine Provencal, Tobias Wiechmann, Elisabeth B Binder, Sebastian W Giakas, Barbara J Roeber, Seth D Pollak
Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade...
December 2017: Development and Psychopathology
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