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https://www.readbyqxmd.com/read/29346529/echocardiographic-criteria-to-detect-unicuspid-aortic-valve-morphology
#1
Sebastian Ewen, Irem Karliova, Petra Weber, Stephan H Schirmer, Hashim Abdul-Khaliq, Jakob Schöpe, Felix Mahfoud, Hans-Joachim Schäfers
Aims: Unicuspid aortic valve (UAV) is a rare congenital malformation associated with severe aortic stenosis or regurgitation. This study aimed to systematically determine echocardiographic criteria to identify UAV. Methods and results: All patients underwent a preoperative baseline examination, including echocardiography. A total of 69 patients with intraoperatively confirmed UAV underwent an aortic valve repair procedure between August 2001 and May 2011. To compare the findings of UAV cases with those of other valve morphologies, we examined 99 consecutive patients with a bicuspid aortic valve (BAV) and 103 consecutive patients with a tricuspid aortic valve (TAV) undergoing isolated aortic valve surgery before May 2016...
January 15, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29346321/new-control-paradigms-for-resources-saving-an-approach-for-mobile-robots-navigation
#2
Rafael Socas, Raquel Dormido, Sebastián Dormido
In this work, an event-based control scheme is presented. The proposed system has been developed to solve control problems appearing in the field of Networked Control Systems (NCS). Several models and methodologies have been proposed to measure different resources consumptions. The use of bandwidth, computational load and energy resources have been investigated. This analysis shows how the parameters of the system impacts on the resources efficiency. Moreover, the proposed system has been compared with its equivalent discrete-time solution...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346300/trapezium-bone-density-a-comparison-of-measurements-by-dxa-and-ct
#3
Sebastian Breddam Mosegaard, Kamille Breddam Mosegaard, Nadia Bouteldja, Torben Bæk Hansen, Maiken Stilling
Bone density may influence the primary fixation of cementless implants, and poor bone density may increase the risk of implant failure. Before deciding on using total joint replacement as treatment in osteoarthritis of the trapeziometacarpal joint, it is valuable to determine the trapezium bone density. The aim of this study was to: (1) determine the correlation between measurements of bone mineral density of the trapezium obtained by dual-energy X-ray absorptiometry (DXA) scans by a circumference method and a new inner-ellipse method; and (2) to compare those to measurements of bone density obtained by computerized tomography (CT)-scans in Hounsfield units (HU)...
January 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29346247/concurrent-versus-sequential-intrapleural-instillation-of-tissue-plasminogen-activator-and-deoxyribonuclease-for-pleural-infection
#4
Fayez Kheir, George Cheng, Estefania Rivera, Alejandro Folch, Erik Folch, Fernandez-Bussy Sebastian, Colleen Keyes, Mihir Parikh, Colleen Channick, Alex Chee, Adnan Majid
BACKGROUND: Treatment of pleural infection with instillation of sequential intrapleural tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase) twice daily for a total of 6 doses has been shown to decrease surgical referral and improve radiographic imaging. This labor-intensive regimen was empirically chosen. Thus, it remains unclear whether the 2 drugs can be administered immediately one after the other (concurrent administration) instead of instilling them separately with a 1-hour to 2-hour interval in between (sequential administration)...
January 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29345729/sinus-node-dysfunction-after-heart-transplantation-how-much-pacing-is-required
#5
Florian Ernst Martin Herrmann, Petra Wellmann, Sebastian Sadoni, René Schramm, Christian Hagl, Gerd Juchem
INTRODUCTION: We investigated the development of sinus node dysfunction (SND) requiring pacemaker implantation after heart transplant (HTx) especially regarding pacing burden in these patients. PATIENTS AND METHODS: Patients requiring a pacemaker for SND were compared to all other patients in an HTx cohort including transplant patients from 1981-2016. RESULTS: SND requiring pacemaker implantation developed in 118 patients (10%). These patients had received a biatrial anastomosis more frequently than those in the No SND group 95...
January 18, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29345706/tuning-the-nucleophilicity-of-electron-rich-diborane-4-compounds-with-bridging-guanidinate-substituents-by-substitution
#6
Julian Horn, Anna Widera, Sebastian Litters, Elisabeth Kaifer, Hans-Jörg Himmel
Diborane(4) compounds are versatile reagents in synthetic chemistry. Generally, diboranes(4) with sp2-hybridized boron atoms react as electrophiles. By contrast, the chemistry of nucleophilic diborane(4) compounds with two sp3-hybridized boron atoms is very much underdeveloped. In this work, we systematically vary the substituents of electron-rich diborane(4) compounds with bridging guanidinate substituents. In this way, five new diboranes are synthesized and fully characterized. Using quantum chemical computations, we show that the electronic properties and reactivity of these compounds can be rationally varied by the choice of substituents...
January 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29345692/erratum-publisher-s-note-implications-of-short-time-scale-dynamics-on-long-time-processes-struct-dyn-4-061507-2017
#7
Krystel El Hage, Sebastian Brickel, Sylvain Hermelin, Geoffrey Gaulier, Cédric Schmidt, Luigi Bonacina, Siri C van Keulen, Swarnendu Bhattacharyya, Majed Chergui, Peter Hamm, Ursula Rothlisberger, Jean-Pierre Wolf, Markus Meuwly
[This corrects the article DOI: 10.1063/1.4996448.].
January 2018: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/29345516/association-between-weather-related-factors-and-cardiac-arrest-of-presumed-cardiac-etiology-a-prospective-observational-study-based-on-out-of-hospital-care-data
#8
Mario Hensel, Daniel Geppert, Jan F Kersten, Markus Stuhr, Jürgen Lorenz, Sebastian Wirtz, Thoralf Kerner
OBJECTIVE: The objective of this study was to determine the association between weather-related factors and out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology. METHODS: This was a prospective observational study performed in a prehospital setting. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Weather data (temperature, humidity, air pressure, wind speed) were obtained every minute and matched with the associated rescue mission data...
January 18, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29345080/environmental-adaptation-and-vertical-dissemination-of-esbl-pampc-producing-escherichia-coli-in-an-integrated-broiler-production-chain-in-the-absence-of-an-antibiotic-treatment
#9
Michaela Projahn, Katrin Daehre, Torsten Semmler, Sebastian Guenther, Uwe Roesler, Anika Friese
High prevalence numbers of extended-spectrum beta-lactamase- (ESBL-)/plasmid-mediated AmpC beta-lactamase- (pAmpC-) producing Escherichia coli in broiler chicken and their distribution along the broiler production chain is an ongoing problem in food production. We, therefore, investigated resistant isolates along the broiler production chain to determine whether there is a constantly occurring direct vertical transmission of the ESBL-/pAmpC-producing E. coli from the parent flocks to their offspring or not...
January 17, 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29344985/probing-the-microscopic-environment-of-23-na-ions-in-brain-tissue-by-mri-on-the-accuracy-of-different-sampling-schemes-for-the-determination-of-rapid-biexponential-t2-decay-at-low-signal-to-noise-ratio
#10
Jonathan M Lommen, Sebastian Flassbeck, Nicolas G R Behl, Sebastian Niesporek, Peter Bachert, Mark E Ladd, Armin M Nagel
PURPOSE: To investigate and to reduce influences on the determination of the short and long apparent transverse relaxation times ( T2,s*, T2,l*) of 23 Na in vivo with respect to signal sampling. METHODS: The accuracy of T2* determination was analyzed in simulations for five different sampling schemes. The influence of noise in the parameter fit was investigated for three different models. A dedicated sampling scheme was developed for brain parenchyma by numerically optimizing the parameter estimation...
January 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29344901/imaging-characteristics-and-first-experience-of-68ga-thp-psma-a-novel-probe-for-rapid-kit-based-ga-68-labeling-and-pet-imaging-comparative-analysis-with-68ga-psma-i-t
#11
Thorsten Derlin, Sebastian Schmuck, Cathleen Juhl, Steffi Teichert, Johanna Zörgiebel, Hans-Jürgen Wester, Sophie M Schneefeld, Almut C A Walte, James T Thackeray, Tobias L Ross, Frank M Bengel
PURPOSE: [68Ga]Trishydroxypyridinone (THP)-prostate-specific membrane antigen (PSMA) is a novel tracer that can be labeled in one step by cold reconstitution of a kit with unprocessed generator eluate, targeting PSMA via the lysine-urea-glutamate (KuE) motif. The aim of this study was to evaluate the human imaging characteristics of [68Ga]THP-PSMA. PROCEDURES: [68Ga]THP-PSMA positron emission tomography (PET)/x-ray computed tomography (CT) was performed in 25 patients with biochemical recurrence after radical prostatectomy for prostate cancer...
January 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29344846/evaluation-of-psychosocial-and-biological-parameters-in-women-seeking-for-a-caesarean-section-and-women-who-are-aiming-for-vaginal-delivery-a-cross-sectional-study
#12
Benjamin Tuschy, Sebastian Berlit, Paul Stützer, Stefanie Lis, Christian Schmahl, Ulf Baumgärtner, Marc Sütterlin
PURPOSE: To investigate psychosocial and biological parameters that may influence decision-making concerning the mode of delivery in women with caesarean section on maternal request (CSMR). METHODS: Two hundred and two women were enrolled prospectively. The study sample (n = 93) consisted of women who aimed for CSMR, the control sample were women who seeked for vaginal delivery (n = 109). Parturients of both samples were enrolled during the pre-birth counselling at the delivery room at the University Medical Centre Mannheim, University Heidelberg, Germany...
January 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29344730/skeletal-dissemination-in-paget-s-disease-of-the-spine
#13
REVIEW
Tim Rolvien, Sebastian Butscheidt, Jozef Zustin, Michael Amling
PURPOSE: Paget's disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine. METHODS: Case report. RESULTS: A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration...
January 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29344212/coexistence-of-sarcoidosis-and-metastatic-lesions-a-diagnostic-and-therapeutic-dilemma
#14
Christoph Spiekermann, Meike Kuhlencord, Sebastian Huss, Claudia Rudack, Daniel Weiss
Sarcoidosis, a chronic, inflammatory disease that affects various different organs, is characterized by noncaseating epitheloid granulomas. This systemic inflammatory process is associated with an increased risk of cancer. Several cases of sarcoidosis that mimic metastatic tumor progression in radiological findings have been reported so far. However, there are also cases that have presented a coexistence of sarcoidosis and metastasis, which have caused a diagnostic and therapeutic dilemma. Due to inadequate current therapies, a reliable differentiation between benign and malignant lesions is crucial...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343427/controlled-attenuation-parameter-and-alcoholic-hepatic-steatosis-diagnostic-accuracy-and-role-of-alcohol-detoxification
#15
Maja Thiele, Vanessa Rausch, Gabriele Fluhr, Maria Kjærgaard, Felix Piecha, Johannes Mueller, Beate Katharina Straub, Monica Lupşor-Platon, Victor De-Ledinghen, Helmut Karl Seitz, Sönke Detlefsen, Bjørn Madsen, Aleksander Krag, Sebastian Mueller
BACKGROUND AND AIMS: Controlled attenuation parameter (CAP) is a novel non-invasive measure of hepatic steatosis, but has not been evaluated in alcoholic liver disease. We therefore aimed to validate CAP for assessment of biopsy-verified alcoholic steatosis and to study the effect of alcohol detoxification on CAP. METHODS: Cross-sectional, biopsy-controlled, diagnostic study in four European liver centers. Consecutive alcohol-overusing patients underwent concomitant CAP, regular ultrasound and liver biopsy...
January 14, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29342854/impact-of-prolonged-blood-incubation-and-extended-serum-storage-at-room-temperature-on-the-human-serum-metabolome
#16
Beate Kamlage, Sebastian Neuber, Bianca Bethan, Sandra González Maldonado, Antje Wagner-Golbs, Erik Peter, Oliver Schmitz, Philipp Schatz
Metabolomics is a powerful technology with broad applications in life science that, like other -omics approaches, requires high-quality samples to achieve reliable results and ensure reproducibility. Therefore, along with quality assurance, methods to assess sample quality regarding pre-analytical confounders are urgently needed. In this study, we analyzed the response of the human serum metabolome to pre-analytical variations comprising prolonged blood incubation and extended serum storage at room temperature by using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) -based metabolomics...
January 13, 2018: Metabolites
https://www.readbyqxmd.com/read/29342363/differential-effects-of-inhibitory-g-protein-isoforms-on-g-protein-gated-inwardly-rectifying-k-currents-in-adult-murine-atria
#17
Muriel Nobles, David Montaigne, Sonia Sebastian, Lutz Birnbaumer, Andrew Tinker
G-protein gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G-protein alpha subunits can both mediate activation via acetylcholine but can also supress basal currents in the absence of agonist. We studied this phenomenon using whole cell patch clamping in murine atria from mice with global genetic deletion of Gαi2, combined deletion of Gαi1/Gαi3 and littermate controls...
January 17, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29342203/biological-pathways-underlying-the-association-of-red-cell-distribution-width-and-adverse-clinical-outcome-results-of-a-prospective-cohort-study
#18
Giedre Zurauskaite, Marc Meier, Alaadin Voegeli, Daniel Koch, Sebastian Haubitz, Alexander Kutz, Luca Bernasconi, Andreas Huber, Mario Bargetzi, Beat Mueller, Philipp Schuetz
BACKGROUND: Red cell distribution width (RDW) predicts disease outcome in several patient populations, but its prognostic value in addition to other disease parameters in unselected medical inpatients remains unclear. Our aim was to investigate the association of admission RDW levels and mortality adjusted for several disease pathways in unselected medical patients from a previous multicenter study. METHODS: We included consecutive adult, medical patients at the time point of hospital admission through the emergency department into this observational, cohort study...
2018: PloS One
https://www.readbyqxmd.com/read/29341920/effect-of-structural-factors-on-release-profiles-of-camptothecin-from-block-copolymer-conjugates-with-high-load-of-drug
#19
Andrzej Plichta, Sebastian Kowalczyk, Ewa Olędzka, Marcin Sobczak, Marcin Strawski
The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of D-PLA units and poly(ethylene glycol) methyl ether methacrylate (PEGMA). Six PLA, non-toxic macroinitiators (MIs), terminated with α-bromoester were synthesized. MIs were subjected to polymerization of CPT methacrylic derivative (CPTMA) with PEGMA at various ratios...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341630/terahertz-sum-frequency-excitation-of-a-raman-active-phonon
#20
Sebastian Maehrlein, Alexander Paarmann, Martin Wolf, Tobias Kampfrath
In stimulated Raman scattering, two incident optical waves induce a force oscillating at the difference of the two light frequencies. This process has enabled important applications such as the excitation and coherent control of phonons and magnons by femtosecond laser pulses. Here, we experimentally and theoretically demonstrate the so far neglected up-conversion counterpart of this process: THz sum-frequency excitation of a Raman-active phonon mode, which is tantamount to two-photon absorption by an optical transition between two adjacent vibrational levels...
September 22, 2017: Physical Review Letters
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