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https://www.readbyqxmd.com/read/28214491/relationship-between-patient-reported-symptoms-limitations-in-daily-activities-and-psychological-impact-in-varicose-veins
#1
Rajiv Mallick, Brajesh Kumar Lal, Claire Daugherty
OBJECTIVE: The objective of this study was to evaluate the relationship between patient-reported symptoms, functional limitations, and psychological impact of varicose veins (VVs) vs pathophysiologic mechanism, incorporating demographic and behavioral factors. METHODS: We conducted a pooled analysis from two clinical studies (Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction Incompetence [VANISH-1] and Polidocanol Endovenous Microfoam Versus Vehicle for the Treatment of Saphenofemoral Junction Incompetence [VANISH-2]) in patients with VVs (superficial venous reflux only)...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28214489/ablation-of-the-great-saphenous-vein-with-nontumescent-n-butyl-cyanoacrylate-versus-endovenous-laser-therapy
#2
İsmail Koramaz, Helin El Kılıç, Fatih Gökalp, Macit Bitargil, Nilüfer Bektaş, Ersoy Engin, Mehmet Taşkın Egici, Ahmet Kürşat Bozkurt
OBJECTIVE: The endovenous application of n-butyl cyanoacrylate (NBCA) is a new nontumescent ablation technique for the treatment of venous insufficiency. The aim of this study was to retrospectively compare an NBCA-based ablation method with endovenous laser ablation (EVLA) for the management of incompetent great saphenous veins. METHODS: Between May 2013 and August 2014, there were 339 patients with incompetent varicose veins who were treated with either the endovenous application of NBCA (VariClose Vein Sealing System [VVSS]; Biolas, Ankara, Turkey) or EVLA...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28214289/bone-health-in-facioscapulohumeral-muscular-dystrophy-a-cross-sectional-study
#3
Hema Chagarlamudi, Alastair Corbett, Marion Stoll, Genila Bibat, Carla Grosmann, Carly Matichak Stock, Nikia Stinson, Jay Shapiro, Kathryn Wagner
INTRODUCTION: We provide a comprehensive overview of bone health in facioscapulohumeral muscular dystrophy (FSHD). METHODS: Ninety-four adult individuals with FSHD1 from two sites were included in this cross-sectional study. Clinical characteristics and determinants of bone health were examined. Relationships between bone mineral density (BMD), strength and function were explored. RESULTS: Nearly a third of subjects were deficient in vitamin D3...
February 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28214122/anaerobic-co-digestion-of-recalcitrant-agricultural-wastes-characterizing-of-biochemical-parameters-of-digestate-and-its-impacts-on-soil-ecosystem
#4
Adele Muscolo, Giovanna Settineri, Teresa Papalia, Emilio Attinà, Carmelo Basile, Maria Rosaria Panuccio
Anaerobic digestion (AD) of organic wastes is a promising alternative to landfilling for reducing Greenhouse Gas Emission (GHG) and it is encouraged by current regulation in Europe. Biogas-AD produced, represents a useful source of green energy, while its by-product (digestate) is a waste, that needs to be safely disposal. The sustainability of anaerobic digestion plants partly depends on the management of their digestion residues. This study has been focused on the environmental and economic benefits of co-digest recalcitrant agricultural wastes such olive wastes and citrus pulp, in combination with livestock wastes, straw and cheese whey for biogas production...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28214118/optimizing-peri-urban-ecosystems-pure-to-re-couple-urban-rural-symbiosis
#5
REVIEW
Yong-Guan Zhu, Brian J Reid, Andrew A Meharg, Steve A Banwart, Bo-Jie Fu
Globally, rapid urbanization, along with economic development, is dramatically changing the balance of biogeochemical cycles, impacting upon ecosystem services and impinging on United Nation global sustainability goals (inter alia: sustainable cities and communities; responsible consumption and production; good health and well-being; clean water and sanitation, and; to protect and conserve life on land and below water). A key feature of the urban ecosystems is that nutrient stocks, carbon (C), nitrogen (N) and phosphorus (P), are being enriched...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28213812/the-neuroscience-of-human-decision-making-through-the-lens-of-learning-and-memory
#6
Lesley K Fellows
We are called upon to make decisions, large and small, many times a day. Whether in the voting booth, the stock exchange, or the cafeteria line, we identify potential options, estimate and compare their subjective values, and make a choice. Decision-making has only recently become a focus for cognitive neuroscience. The last two decades have seen rapid progress in our understanding of the brain basis of at least some aspects of this rather complex aspect of cognition. This work has provided fresh perspectives on poorly understood brain regions, such as orbitofrontal cortex and ventral striatum...
February 18, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28213513/runx1-cooperates-with-flt3-itd-to-induce-leukemia
#7
Kira Behrens, Katrin Maul, Nilgün Tekin, Neele Kriebitzsch, Daniela Indenbirken, Vladimir Prassolov, Ursula Müller, Hubert Serve, Jörg Cammenga, Carol Stocking
Acute myeloid leukemia (AML) is induced by the cooperative action of deregulated genes that perturb self-renewal, proliferation, and differentiation. Internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase are common mutations in AML, confer poor prognosis, and stimulate myeloproliferation. AML patient samples with FLT3-ITD express high levels of RUNX1, a transcription factor with known tumor-suppressor function. In this study, to understand this paradox, we investigated the impact of RUNX1 and FLT3-ITD coexpression...
February 17, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28212833/dietary-administration-of-pontogammarus-maeoticus-extract-affects-immune-responses-stress-resistance-feed-intake-and-growth-performance-of-caspian-roach-rutilus-caspicus-fingerlings
#8
Rudabeh Rufchaei, Seyed Hossein Hoseinifar, Alireza Mirzajani, Hien Van Doan
Dietary administration of immunostimulants showed promising results for elevation of immune responses and disease resistance. The aim of the present study was to investigate the effects of dietary Pontogammarus (Pontogammarus maeoticus) extract on innate immune response, stress resistance, feed intake and growth performance of the Caspian roach fingerling. Two levels of P. maeoticus extract dilution with distilled water 1:25 [T1] and 1:50 [T2] were prepared. Experimental diets were prepared by top-spraying the basal diet with equal amount (2%) of diluted extracts...
February 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28210817/-compression-therapy-of-chronic-leg-ulcers-practical-aspects
#9
J Dissemond, K Protz, J Hug, S Reich-Schupke, K Kröger
Compression therapy, together with modern moist wound treatment, is the basis for a successful conservative treatment of patients with chronic leg ulcers. In clinical practice, it is often the patients themselves who apply compression therapies. Many of the mostly elderly patients, however, are not able to reach their legs and feet due to movement restrictions, such as arthritis, arthrosis and even obesity. An adequate compression therapy also requires extensive experience and regular training. In practice only the minority of patients can perform bandaging well and therefore this should not be recommended...
February 16, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28209833/metagenome-assembled-draft-genome-sequence-of-a-novel-microbial-stenotrophomonas-maltophilia-strain-isolated-from-caenorhabditisremanei-tissue
#10
Janna L Fierst, Duncan A Murdock, Chamali Thanthiriwatte, John H Willis, Patrick C Phillips
Stenotrophomonas maltophilia is a Gram-negative aerobic bacterium and emerging nosocomial pathogen. Here, we present a draft genome sequence for an S. maltophilia strain assembled from a metagenomic DNA extract isolated from a laboratory stock of the nematode worm Caenorhabditis remanei.
February 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28209594/adolescents-and-young-adults-with-acute-lymphoblastic-leukemia-and-acute-myeloid-leukemia-impact-of-care-at-specialized-cancer-centers-on-survival-outcome
#11
Julie Wolfson, Can-Lan Sun, Laura Wyatt, Wendy Stock, Smita Bhatia
Background: Adolescents and young adults (AYA; 15-39 years) with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) experience inferior survival when compared with children. Impact of care at NCI-designated Comprehensive Cancer Centers (CCC) or Children's Oncology Group sites (COG) on survival disparities remains unstudied.Methods: Using the Los Angeles cancer registry, we identified 1,870 ALL or AML patients between 1 and 39 years at diagnosis. Cox regression analyses assessed risk of mortality; younger age + CCC/COG served as the referent group...
February 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28209591/psychosocial-therapies-for-the-adjunctive-treatment-of-bipolar-disorder-in-adults-network-meta-analysis
#12
REVIEW
Mary Lou Chatterton, Emily Stockings, Michael Berk, Jan J Barendregt, Rob Carter, Cathrine Mihalopoulos
BackgroundFew trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.AimsTo combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).MethodSystematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF)...
February 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28208227/integrating-remotely-sensed-fires-for-predicting-deforestation-for-redd
#13
Dolors Armenteras, Cerian Gibbes, Jesús A Anaya, Liliana M Dávalos
Fire is an important tool in tropical forest management, as it alters forest composition, structure, and the carbon budget. The United Nations program on Reducing Emissions from Deforestation and Forest Degradation (REDD+) aims to sustainably manage forests, as well as conserve and enhance their carbon stocks. Despite the crucial role of fire management, decision-making on REDD+ interventions fails to systematically include fires. Here, we address this critical knowledge gap in two ways. First, we review REDD+ projects and programs to assess the inclusion of fires in monitoring, reporting and verification (MRV) systems...
February 16, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28207832/towards-sustainable-fishery-management-for-skates-in-south-america-the-genetic-population-structure-of-zearaja-chilensis-and-dipturus-trachyderma-chondrichthyes-rajiformes-in-the-south-east-pacific-ocean
#14
Carolina Vargas-Caro, Carlos Bustamante, Michael B Bennett, Jennifer R Ovenden
The longnose skates (Zearaja chilensis and Dipturus trachyderma) are the main component of the elasmobranch fisheries in the south-east Pacific Ocean. Both species are considered to be a single stock by the fishery management in Chile however, little is known about the level of demographic connectivity within the fishery. In this study, we used a genetic variation (560 bp of the control region of the mitochondrial genome and ten microsatellite loci) to explore population connectivity at five locations along the Chilean coast...
2017: PloS One
https://www.readbyqxmd.com/read/28207630/clinical-trials-for-immunosuppression-in-transplantation-the-case-for-reform-and-change-in-direction
#15
Philip J O'Connell, Dirk Kuypers, Roslyn R Mannon, Michael Abecassis, Stephen Chadban, John S Gill, Barbara Murphy, Peter W Nickerson, Jesse D Schold, Peter Stock, Daniel Seron, Rita Alloway, Jonathan Bromberg, Klemens Budde, Stanley Jordan, Christophe Legendre, Carmen Lefaucheur, Minnie Sarwall, Dorry Segev, Mark D Stegall, Stefan G Tullius, Germaine Wong, E Steve Woodle, Nancy Ascher, Randall E Morris
Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compared to current standard of care. Current trial design is not leading to novel therapies improving long term outcomes and safety, and hence important unmet clinical needs in transplantation remain unanswered...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28207619/iliac-crest-regeneration-a-retrospective-study-of-14-years-of-follow-up
#16
Anastasios Christodoulou, Achilleas Boutsiadis, Evangellos Christodoulou, Petros Antonarakos, Panagiotis Givissis, Ippokratis Hatzokos
STUDY DESIGN: This is a retrospective study analysis. OBJECTIVE: The purpose of our study was to evaluate the healing process of the ilium after being used as a bone graft donor site in the treatment of adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Iliac crest bone grafts have been proven to be the most reliable means for solid fusion in spine surgery. Nevertheless, few reports in the literature describe the ability of the iliac crest to regenerate...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28205573/extracellular-protonation-modulates-cell-cell-interaction-mechanics-and-tissue-invasion-in-human-melanoma-cells
#17
Verena Hofschröer, Kevin Alexander Koch, Florian Timo Ludwig, Peter Friedl, Hans Oberleithner, Christian Stock, Albrecht Schwab
Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular acidification. In human melanoma, the Na(+)/H(+) exchanger NHE1 is an important modifier of the tumour nanoenvironment. Here we tested the modulation of cell-cell-adhesion by extracellular pH and NHE1. MV3 tumour spheroids embedded in a collagen matrix unravelled the efficacy of cell-cell contact loosening and 3D emigration into an environment mimicking physiological confinement...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205106/copepod-grazing-and-their-impact-on-phytoplankton-standing-stock-and-production-in-a-tropical-coastal-water-during-the-different-seasons
#18
L Jagadeesan, R Jyothibabu, N Arunpandi, S Parthasarathi
The grazing rate of copepods on the total and size-fractionated phytoplankton biomass in a coastal environment (off Kochi, southwest coast of India) were measured during pre-monsoon (PRM), peak southwest monsoon (PKSWM), late southwest monsoon (LSWM) and post-southwest monsoon (PSWM). The phytoplankton standing stock (chlorophyll a-Chl. a) and growth rate (GR) were less during the PRM (Chl. a 0.58 mg m(-3); GR 0.23 ± 0.02) and PSWM (Chl. a 0.89 mg m(-3); GR 0.30 ± 0.05) compared to PKSWM (Chl. a 6...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28199931/a-personalized-3d-printed-prosthetic-joint-replacement-for-the-human-temporomandibular-joint-from-implant-design-to-implantation
#19
David C Ackland, Dale Robinson, Michael Redhead, Peter Vee Sin Lee, Adrian Moskaljuk, George Dimitroulis
Personalized prosthetic joint replacements have important applications in cases of complex bone and joint conditions where the shape and size of off-the-shelf components may not be adequate. The objective of this study was to design, test and fabricate a personalized 3D-printed prosthesis for a patient requiring total joint replacement surgery of the temporomandibular joint (TMJ). The new 'Melbourne' prosthetic TMJ design featured a condylar component sized specifically to the patient and fixation screw positions that avoid potential intra-operative damage to the mandibular nerve...
February 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28199344/stock-assessment-and-end-to-end-ecosystem-models-alter-dynamics-of-fisheries-data
#20
Laura S Storch, Sarah M Glaser, Hao Ye, Andrew A Rosenberg
Although all models are simplified approximations of reality, they remain useful tools for understanding, predicting, and managing populations and ecosystems. However, a model's utility is contingent on its suitability for a given task. Here, we examine two model types: single-species fishery stock assessment and multispecies marine ecosystem models. Both are efforts to predict trajectories of populations and ecosystems to inform fisheries management and conceptual understanding. However, many of these ecosystems exhibit nonlinear dynamics, which may not be represented in the models...
2017: PloS One
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