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Gastroschisis

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https://www.readbyqxmd.com/read/29628209/outcomes-in-patients-with-short-bowel-syndrome-after-autologous-intestinal-reconstruction-does-etiology-matter
#1
Federica Pederiva, Alberto Sgrò, Riccardo Coletta, Basem Khalil, Antonino Morabito
BACKGROUND: Short bowel syndrome (SBS) is the most common cause of intestinal failure in children. Many factors have been investigated in an attempt to define which parameters influence most survival and ability to wean off parenteral nutrition (PN). The aim of this study was to investigate if aetiology of SBS affects the outcomes in paediatric patients treated with autologous gastrointestinal reconstructive surgery. METHODS: All children with SBS who underwent autologous gastrointestinal reconstructive surgery between 2002 and 2012 were retrospectively reviewed and outcome measures were recorded...
March 12, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29628208/complex-gastroschisis-clinical-spectrum-and-neonatal-outcomes-at-a-referral-center
#2
Pablo Laje, Maria V Fraga, William H Peranteau, Holly L Hedrick, Nahla Khalek, Juliana S Gebb, Julie S Moldenhauer, Mark P Johnson, Alan W Flake, N Scott Adzick
AIM OF THE STUDY: To evaluate the outcomes of neonates with complex gastroschisis (GC), and correlate outcomes with each type of complication. METHODS: Retrospective review of patients with complex GC owing to prenatal and/or postnatal abdominal complications; 2008-2016. Primary outcomes: time to discontinue parenteral nutrition (off-PN), length of stay (LOS) and neonatal survival. MAIN RESULTS: We treated 58 patients with complex gastroschisis owing to abdominal complications, which were: intestinal necrosis at birth (n=9), intestinal atresia (n=16), medical necrotizing enterocolitis (NEC) (n=15), surgical NEC (n=1), in utero volvulus (n=1), vanishing gastroschisis (n=2), severe intestinal dysmotility (n=1), delayed abdominal closure (n=3), abdominal compartment syndrome (n=2) and hiatal hernia/severe gastroesophageal reflux disease (GERD; n=11)...
March 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29617042/use-of-a-gastroschisis-feeding-guideline-to-improve-standardization-of-care-and-patient-outcomes-at-an-urban-children-s-hospital
#3
R Colby Passaro, Kate B Savoie, Eunice Y Huang
BACKGROUND: This study examined clinical outcomes associated with the use of a gastroschisis-specific (GS) feeding advancement guideline. METHODS: We performed a retrospective study of all simple gastroschisis babies (N = 65) treated between June 2009June 2015. We compared patients treated on a postintestinal surgery guideline using either a 1-day (1D) or 3-day (3D) feeding advancement from August 2009-August 2013 with infants treated on a GS guideline from September 2013-June 2015...
April 4, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29589452/-prediction-of-bowel-damage-in-patients-with-gastroschisis
#4
B Frýbová, A Kokešová, R Vlk, M Rygl
INTRODUCTION: Gastroschisis is the most common malformation among abdominal wall defects with the incidence of 1:45000 live birth neonates. Postoperative care for these patients is very difficult due to the risk of abdominal compartment syndrome. The identification of markers that correlate with bowel damage in gastroschisis may prevent this serious postoperative complication. METHODS: Review of the literature. CONCLUSION: Prenatal ultrasound prediction of bowel damage followed by an appropriate surgical strategy is a possibility of optimizing care and outcomes in gastroschisis patients...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29579761/surgical-site-infection-in-a-tertiary-neonatal-surgery-centre
#5
Adiam Y Woldemicael, Sarah Bradley, Caroline Pardy, Justin Richards, Paolo Trerotoli, Stefano Giuliani
INTRODUCTION:  Surgical site infection (SSI) is a key performance indicator to assess the quality of surgical care. Incidence and risk factors for SSI in neonatal surgery are lacking in the literature. AIM:  To define the incidence of SSI and possible risk factors in a tertiary neonatal surgery centre. MATERIALS AND METHODS:  This is a prospective cohort study of all the neonates who underwent abdominal and thoracic surgery between March 2012 and October 2016...
March 26, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29575623/low-serum-fatty-acid-levels-in-pregnancies-with-fetal-gastroschisis-a-prospective-study
#6
Sandra F Centofanti, Rossana P V Francisco, Sonia T Phillippi, Inar A Castro, Mara S Hoshida, Rui Curi, Maria L Brizot
Fetal gastroschisis is a paraumbilical abdominal wall defect with herniation of abdominal organs. The underlying cause of the disease remains unknown; however, studies suggest that nutritional factors may play a role in its development. This prospective case-control study explored the association of serum fatty acid levels of pregnant women and occurrence of gastroschisis. Gastroschisis group comprised 57 pregnant women with fetuses with gastroschisis, and the control group comprised 114 pregnant women with normal fetuses...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29562799/mode-of-delivery-in-pregnancies-with-gastroschisis-according-to-delivery-institution
#7
Jose Duncan, Pranit Chotai, Anna Slagle, Ajay Talati, Eunice Huang, Mauro Schenone
PURPOSE: We aim to compare the mode of delivery in pregnancies with gastroschisis delivered in nonacademic institutions with those delivered in an academic center. MATERIAL AND METHODS: Chart review from 2008 to 2015 was performed. Cesarean delivery rate (CDR), attempted vaginal delivery rate (AVR), planned cesarean rate (PCR) and adverse neonatal outcomes were compared among pregnancies with gastroschisis delivered in nonacademic hospitals with those delivered in an academic institution...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29561958/maternal-administration-of-cannabidiol-promotes-an-anti-inflammatory-effect-on-the-intestinal-wall-in-a-gastroschisis-rat-model
#8
G H Callejas, R L Figueira, F L L Gonçalves, F A P Volpe, A W Zuardi, J A Crippa, J E Hallak, L Sbragia
Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to its anti-inflammatory, antioxidant, and neuroprotective effects, cannabidiol (CBD) has been used as a therapeutic agent in many diseases. Our aim was to test the effect of maternal CBD in the intestine of an experimental model of GS. Pregnant rats were treated over 3 days with CBD (30 mg/kg) after the surgical induction of GS (day 18...
March 15, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29550988/genetic-variants-conferring-susceptibility-to-gastroschisis-a-phenomenon-restricted-to-the-interaction-with-the-environment
#9
Victor M Salinas-Torres, Rafael A Salinas-Torres, Ricardo M Cerda-Flores, Laura E Martínez-de-Villarreal
BACKGROUND: Genes involved in gastroschisis have shown a strong interaction with environmental factors. However, less is known about its influence. We aimed to systematically review the genetic associations of gastroschisis, to summarize whether its genetic susceptibility has been restricted to the interaction with the environment, and to identify significant gaps that remain for consideration in future studies. METHODS: Genetic association studies of gastroschisis published 1980-2017 (PubMed/MEDLINE) were independently searched by two reviewers...
March 17, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29550866/fetal-anterior-abdominal-wall-defects-prenatal-imaging-by-magnetic-resonance-imaging
#10
REVIEW
Teresa Victoria, Savvas Andronikou, Diana Bowen, Pablo Laje, Dana A Weiss, Ann M Johnson, William H Peranteau, Douglas A Canning, N Scott Adzick
Abdominal wall defects range from the mild umbilical cord hernia to the highly complex limb-body wall syndrome. The most common defects are gastroschisis and omphalocele, and the rarer ones include the exstrophy complex, pentalogy of Cantrell and limb-body wall syndrome. Although all have a common feature of viscera herniation through a defect in the anterior body wall, their imaging features and, more important, postnatal management, differ widely. Correct diagnosis of each entity is imperative in order to achieve appropriate and accurate prenatal counseling and postnatal management...
April 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29540463/development-of-a-gastroschisis-core-outcome-set
#11
Benjamin Saul Raywood Allin, Nigel J Hall, Andrew R Ross, Sean S Marven, Jennifer J Kurinczuk, Marian Knight
OBJECTIVE: Outcome reporting heterogeneity impedes identification of gold standard treatments for children born with gastroschisis. Use of core outcome sets (COSs) in research reduces outcome reporting heterogeneity and ensures that studies are relevant to patients. The aim of this study was to develop a gastroschisis COS. DESIGN AND SETTING: Systematic reviews and stakeholder nomination were used to identify candidate outcomes that were subsequently prioritised by key stakeholders in a three-phase online Delphi process and face-to-face consensus meeting using a 9-point Likert scale...
March 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29530019/multiple-midline-defects-identified-in-a-litter-of-golden-retrievers-following-gestational-administration-of-prednisone-and-doxycycline-a-case-series
#12
Joanna L Kaplan, Catherine T Gunther-Harrington, Jessie S Sutton, Joshua A Stern
BACKGROUND: The teratogenic effects of immunomodulatory and certain antimicrobial therapies are described in small rodents and humans. While the described teratogenic effects in small rodents have been extrapolated to make conclusions about its use in the pregnant dam, teratogenic effects of prednisone and doxycycline have not yet been reported in the dog. Here we report and describe midline defects observed in a litter of golden retriever puppies exposed to mid-gestational immunosuppressive and antimicrobial therapy...
March 12, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29523359/the-glucagon-like-peptide-2-axis-capacity-for-production-and-response-following-intestinal-resection-or-repair-of-gastroschisis-in-infants
#13
David L Sigalet, Viona Lam, Mary Brindle, Dana Boctor, Laurie Wallace, Elaine de Heuval, Bollette Hartmann, Jens J Holst
PURPOSE: This study investigates the relationship between the enteric hormone glucagon-like peptide 2 (GLP-2) production, sensitivity, and intestinal adaptation in infants following resection or repair of gastroschisis. METHODS: With IRB approval (UCalgary #10656), consent was obtained from families of infants undergoing surgery for prospective monitoring of nutritional status, GLP-2 levels, and where possible, tissue sampling. RESULTS: Infants who adapted and weaned from parenteral nutrition (PN) had increased GLP-2 (86±32) n=24 vs...
February 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29521606/coincident-myelomeningocele-and-gastroschisis-report-of-2-cases
#14
Jason S Hauptman, Robert Bollo, Rama Damerla, Brian Gibbs, Cecilia Lo, Aviva Katz, Stephanie Greene
Myelomeningocele and gastroschisis, on their own, are both relatively common entities encountered in pediatric surgical care. Coexistence of these pathologies, however, is exceedingly rare. The authors report on 2 patients who presented with myelomeningocele and gastroschisis at birth. They obtained blood for whole-exome analysis for one of the patients and identified 3 mutations that could be related to the underlying anomalies: homozygous mutations in FAM171B and ABCA1 and a hemizygous (X-linked) mutation in COL4A5...
March 9, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29519207/adhd-medication-use-during-pregnancy-and-risk-for-selected-birth-defects-national-birth-defects-prevention-study-1998-2011
#15
Kayla N Anderson, Annelise C Dutton, Cheryl S Broussard, Sherry L Farr, Jennifer N Lind, Susanna N Visser, Elizabeth C Ailes, Stuart K Shapira, Jennita Reefhuis, Sarah C Tinker
OBJECTIVE: The objective of this study was to examine the prevalence of, and maternal characteristics associated with, ADHD medication use before and during pregnancy, and associations between early pregnancy ADHD medication use and risk for 12 selected birth defects. METHOD: We used data from the National Birth Defects Prevention Study (1998-2011), a U.S. population-based case-control study examining risk factors for major structural birth defects. RESULTS: There was an increase in ADHD medication use from 1998-1999 (0...
March 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29506856/short-term-and-family-reported-long-term-outcomes-of-simple-versus-complicated-gastroschisis
#16
Hope E Arnold, Katherine J Baxter, Heather L Short, Curtis Travers, Amina Bhatia, Megan M Durham, Mehul V Raval
BACKGROUND: Our goal is to determine short- and long-term outcomes of simple gastroschisis (SG) and complicated gastroschisis (CG) patients including quality of life (QoL) measures, surgical reoperation rates, and residual gastrointestinal symptom burden. MATERIALS AND METHODS: Retrospective chart review of patients who underwent surgical repair of gastroschisis between January 1, 2009, and December 31, 2012, was performed at a quaternary children's hospital. Parent telephone surveys were conducted to collect information on subsequent operations and current health status as well as to assess QoL using two validated tools...
April 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29499843/impact-of-multidisciplinary-standardization-of-care-for-gastroschisis-treatment-outcomes-and-cost
#17
Candace Haddock, Al Ghalgya Al Maawali, Joseph Ting, Julie Bedford, Kourosh Afshar, Erik D Skarsgard
BACKGROUND/PURPOSE: Elimination of unnecessary practice variation through standardization creates opportunities for improved outcomes and cost-effectiveness. A quality improvement (QI) initiative at our institution used evidence and consensus to standardize management of gastroschisis (GS) from birth to discharge. METHODS: An interdisciplinary team utilized best practice evidence and expert opinion to standardize GS care. Following stakeholder engagement and education, care standardization was implemented in September 2014...
February 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29495915/enhanced-vancomycin-elimination-in-an-infant-following-an-unsuccessful-gastroschisis-repair-surgery
#18
Leesa Prunty, David Miskell
OBJECTIVE: To report the case of an infant who required high-dose vancomycin therapy after an unsuccessful gastroschisis repair surgery. CASE SUMMARY: An infant born at 35 weeks and 5 days of gestation underwent a gastroschisis repair on day of life 47. The repair was unsuccessful causing fluid backup and accumulation into the stomach. A replogle was placed to allow for suctioning of this fluid. During this admission, the patient received 3 courses of vancomycin...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29478887/long-term-outcomes-of-intestinal-rehabilitation-in-children-with-neonatal-very-short-bowel-syndrome-parenteral-nutrition-or-intestinal-transplantation
#19
Lorenzo Norsa, Solene Artru, Cecile Lambe, Cecile Talbotec, Benedicte Pigneur, Frank Ruemmele, Virginie Colomb, Carmen Capito, Christophe Chardot, Florence Lacaille, Olivier Goulet
BACKGROUND & AIMS: Intestinal rehabilitation is the preferred treatment for children with short bowel syndrome (SBS) whatever the residual bowel length, and depends on the accurate management of long-term parenteral nutrition (PN). If nutritional failure develops, intestinal transplantation (ITx) should be discussed and may be life-saving. This study aimed to evaluate survival, PN dependency and nutritional status in children with neonatal very SBS on PN or after ITx, in order to define indications and timing of both treatments...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29458229/primary-closure-versus-bedside-silo-and-delayed-closure-for-gastroschisis-a-truncated-prospective-randomized-trial
#20
Ashwini S Poola, Pablo Aguayo, Jason D Fraser, Richard J Hendrickson, Katrina L Weaver, Katherine W Gonzalez, Shawn D St Peter
BACKGROUND:  We report a prospective randomized trial comparing primary closure (PC) to bedside silo and delayed closure (DC) for babies with gastroschisis. METHODS:  Patients were randomized to PC versus DC. We excluded those with atresia/necrosis, <34 weeks' gestation, or congenital anomalies. The primary outcome was length of stay (LOS). RESULTS:  A total of 38 patients were included from August 2011 to August 2016; 18 patients underwent DC and 20 PC...
February 19, 2018: European Journal of Pediatric Surgery
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