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https://www.readbyqxmd.com/read/29665289/a-whole-body-physiologically-based-pharmacokinetic-model-for-colistin-and-colistin-methanesulfonate-cms-in-rat
#1
Salim Bouchene, Sandrine Marchand, William Couet, Lena E Friberg, Patrice Gobin, Isabelle Lamarche, Nicolas Grégoire, Sven Björkman, Mats O Karlsson
Colistin is a polymyxin antibiotic used to treat patients infected with multidrug-resistant Gram negative bacteria (MDR-GNB). The objective of this work was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model to predict tissue distribution of colistin in rat. The distribution of a drug in a tissue is commonly characterized by its tissue-to-plasma partition coefficient, Kp . Colistin and its prodrug, colistin methanesulfonate (CMS) Kp priors were measured experimentally from rat tissue homogenates or predicted in silico...
April 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29664197/impact-of-systemic-antimicrobial-therapy-on-mucosal-staphylococci-in-a-population-of-dogs-in-northwest-england
#2
Vanessa M Schmidt, Gina Pinchbeck, Tim Nuttall, Steve Shaw, K Marie McIntyre, Neil McEwan, Susan Dawson, Nicola J Williams
BACKGROUND: Antimicrobial-resistant bacteria are increasingly isolated from veterinary patients. OBJECTIVES: To determine risk factors for antimicrobial resistance (AMR) among canine mucosal staphylococci following routine antimicrobial treatment with cefalexin (CFX), clavulanate-amoxicillin (AC), cefovecin (CVN), clindamycin (CD) or a fluoroquinolone (FQ). ANIMALS: Mucosal swab samples (n = 463) were collected from 127 dogs pre-treatment, immediately, and at one- and three-months post-treatment...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29659523/antibacterial-efficacy-of-silver-nanoparticles-on-endometritis-caused-by-prevotella-melaninogenica-and-arcanobacterum-pyogenes-in-dairy-cattle
#3
Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim
Bovine postpartum diseases remain one of the most significant and highly prevalent illnesses with negative effects on the productivity, survival, and welfare of dairy cows. Antibiotics are generally considered beneficial in the treatment of endometritis; however, frequent usage of each antibiotic drug is reason for the emergence of multidrug resistance (MDR) of the pathogenic microorganisms, representing a major impediment for the successful diagnosis and management of infectious diseases in both humans and animals...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29658045/potential-of-borojoa-patinoi-cuatrecasas-water-extract-to-inhibit-nosocomial-antibiotic-resistant-bacteria-and-cancer-cell-proliferation-in-vitro
#4
Clemencia Chaves-López, Donatella Usai, Matthew Gavino Donadu, Annalisa Serio, Robert Tulio González-Mina, Maria Chiara Simeoni, Paola Molicotti, Stefania Zanetti, Antonio Pinna, Antonello Paparella
Borojó (Borojoa patinoi Cuatrec.) is a fruit used in Colombian traditional medicine with supposed antihypertensive, antitumoral, diuretic, healing, immunological, anti-inflammatory and aphrodisiac effects. To explore the relative merits in terms of biological activities of borojó aqueous extract (BAE), we investigated in vitro its antimicrobial activity on nosocomial pathogenic and multidrug resistant (MDR) strains of Pseudomonas aeruginosa (6), Staphylococcus aureus (1) and Candida species (6), as well as its cytotoxicity on human conjunctive Wong-Kilbourne derivative (WKD) cells and Caco-2 cells from heterogeneous human epithelial colorectal adenocarcinoma...
April 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29657216/colistin-induced-myasthenic-syndrome-in-a-patient-with-end-stage-renal-disease
#5
Pratim Sengupta, Sumanta Biswas
With resurgence of multidrug resistance (MDR) bacteria and no new novel broad-spectrum antibiotic in research pipeline, usage of older generation antibiotics, once discarded due to their toxicity profile are becoming popular again. Often these drugs are the only option left in managing MDR bacteria-related sepsis. Colistin is one of such antibiotic which is often used in recent times after decades of its avoidance due to its diverse toxicity profile. In this case report, we present a rare myasthenic syndrome like neuromuscular complication developed in a patient after receiving colistin for treatment of MDR Klebsiella-related urosepsis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29649549/bloodstream-infections-in-cancer-patients-risk-factors-associated-with-mortality
#6
Beda Islas-Muñoz, Patricia Volkow-Fernández, Cynthia Ibanes-Gutiérrez, Alberto Villamar-Ramírez, Diana Vilar-Compte, Patricia Cornejo-Juárez
OBJECTIVE: The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients with bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDRB). METHODS: We conducted a prospective observational study at a cancer referral center from August 2016 to July 2017, which included all BSI. RESULTS: 4,220 patients were tested with blood cultures; 496 were included. Mean age was 48 years...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#7
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29627985/strategic-approaches-to-overcome-resistance-against-gram-negative-pathogens-using-%C3%AE-lactamase-inhibitors-and-%C3%AE-lactam-enhancers-the-activity-of-three-novel-diazabicyclooctanes-wck-5153-zidebactam-wck-5107-and-wck-4234
#8
Krisztina M Papp-Wallace, Nhu Q Nguyen, Michael R Jacobs, Christopher R Bethel, Melissa D Barnes, Vijay Kumar, Saralee Bajaksouzian, Susan D Rudin, Philip N Rather, Satish Bhavsar, Tadiparthi Ravikumar, Prasad K Deshpande, Vijay Patil, Ravindra Yeole, Sachin S Bhagwat, Mahesh V Patel, Focco van den Akker, Robert A Bonomo
Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of paramount importance. Here, three novel diazabicyclooctanes (DBOs), WCK 5153, zidebactam (WCK 5107), and WCK 4234 (compounds 1-3) were synthesized and biochemically characterized against clinically important bacteria. Compound 3 inhibited class A, C and D β-lactamases with unprecedented k2/K values against OXA carbapenemases...
April 7, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29625658/quorum-sensing-a-less-known-mode-of-communication-among-fungi
#9
REVIEW
Sajad Ahmad Padder, Rajendra Prasad, Abdul Haseeb Shah
Quorum sensing (QS), a density-dependent signaling mechanism of microbial cells, involves an exchange and sense of low molecular weight signaling compounds called autoinducers. With the increase in population density, the autoinducers accumulate in the extracellular environment and once their concentration reaches a threshold, many genes are either expressed or repressed. This cell density-dependent signaling mechanism enables single cells to behave as multicellular organisms and regulates different microbial behaviors like morphogenesis, pathogenesis, competence, biofilm formation, bioluminescence, etc guided by environmental cues...
May 2018: Microbiological Research
https://www.readbyqxmd.com/read/29623139/rapd-pcr-profile-antibiotic-resistance-prevalence-of-arma-gene-and-detection-of-kpc-enzyme-in-klebsiella-pneumoniae-isolates
#10
Arezoo Saadatian Farivar, Jamileh Nowroozi, Gita Eslami, Azar Sabokbar
The increasing prevalence of multidrug-resistant Klebsiella pneumoniae strains isolated from hospitals shows the limitation of recent antibiotics used for bacterial eradication. In this study, 81 K. pneumoniae isolates were collected from three hospitals in Tehran. Antibiotic susceptibility test showed the highest rates of resistance to cefotaxim (85.5%) and ceftazidime (78.3%), and the lowest rates of resistance were detected for colistin (16.9%), streptomycin (16.8%), and chloroamphenicol (21.7%). Eleven different resistance patterns were observed...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29619432/antibacterial-activity-of-dracontomelon-dao-extracts-on-methicillin-resistant-s-aureus-mrsa-and-e-coli-multiple-drug-resistance-mdr
#11
Yuniati Yuniati, Nurul Hasanah, Sjarif Ismail, Silvia Anitasari, Swandari Paramita
Background: Staphylococcus aureus , methicillin-resistant and Escherichia coli , multidrug-resistant included in the list of antibiotic-resistant priority pathogens from WHO. As multidrug-resistant bacteria problem is increasing, it is necessary to probe new sources for identifying antimicrobial compounds. Medicinal plants represent a rich source of antimicrobial agents. One of the potential plants for further examined as antibacterial is Dracontomelon dao (Blanco) Merr. & Rolfe. The present study designed to find the antibacterial activity of D...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29615264/extended-spectrum-beta-lactamase-esbl-and-carbapenemase-producing-enterobacteriaceae-in-water-sources-in-lebanon
#12
Mohamad Diab, Monzer Hamze, Richard Bonnet, Estelle Saras, Jean-Yves Madec, Marisa Haenni
Extended-spectrum beta-lactamases (ESBLs) have been recurrently reported in both human and veterinary medicine, and carbapenemases have also emerged in these two sectors. Such resistance phenotypes were increasingly reported in the environment, which both receives and further disseminates multidrug-resistant (MDR) bacteria. Here, we report the high contamination of water samples (68.2%; 15/22) collected in estuaries in Lebanon. From these 15 contaminated sites, a total of 21 ESBL-producing (mostly harbouring the blaCTX-M-15 gene) and four carbapenemase-producing (two blaOXA-48 and two blaOXA-244 ) Enterobacteriaceae were recovered...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29614973/in-vitro-antibacterial-activity-of-bioactive-glass-s53p4-on-multiresistant-pathogens-causing-osteomyelitis-and-prosthetic-joint-infection
#13
Mateus Trinconi Cunha, Maria Aparecida Murça, Stanley Nigro, Giselle Burlamaqui Klautau, Mauro José Costa Salles
BACKGROUND: Conventional local treatment for medullary osteomyelitis (OM) includes insertion of antibiotic-loaded polymethylmethacrylate (PMMA) cement. Nevertheless, PMMA may delivery irregular concentration of antibiotic to surrounding tissue. We aimed to compare the in vitro antibacterial activity of Bioactive Glass (BAG) S53P4, which is a compound showing local antibacterial activity, to that of antibiotic-loaded PMMA against multidrug resistant bacteria from OM isolates. METHODS: We studied convenience samples of multidrug resistant (MDR) microorganisms obtained from patients presenting OM and prosthetic joint infection (PJI)...
April 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29611447/investigational-drugs-for-the-treatment-of-infections-caused-by-multidrug-resistant-gram-negative-bacteria
#14
Lindsay M Avery, David P Nicolau
Infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB) are associated with significant mortality and costs. New drugs in development to combat these difficult-to-treat infections primarily target carbapenem-resistant Enterobacteriaceae, MDR Pseudomonas aeruginosa, and MDR Acinetobacter baumannii. Areas Covered: The authors summarize in vitro and in vivo efficacy studies, as well as available clinical trial findings, for new agents in development for treatment of infection caused by MDR-GNB...
April 3, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29605810/design-synthesis-and-biological-evaluation-of-c-4-substituted-monobactams-as-antibacterial-agents-against-multidrug-resistant-gram-negative-bacteria
#15
Qunhuan Kou, Ting Wang, Feng Zou, Shuhua Zhang, Qian Chen, Yushe Yang
A series of novel pyridone conjugated monobactams with various substituents at the (4) position were synthesized and evaluated for their antibacterial activities against a panel of multidrug-resistant (MDR) Gram-negative bacteria in vitro. Compounds 46d, 54 and 75e displayed good to moderate activities against P. aeruginosa, among which the activity of 75e against P. aeruginosa was comparable to that of BAL30072 under iron limitation condition. Compounds 35, 46d, 54, 56a, 56c and 56d exhibited good to excellent antibacterial activities against E...
March 23, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29604581/synthesis-and-structure-activity-relationship-of-novel-bisindole-amidines-active-against-mdr-gram-positive-and-gram-negative-bacteria
#16
Yonghua Liu, Xinxin Hu, Yanbin Wu, Weixing Zhang, Xiaofang Chen, Xuefu You, Laixing Hu
A series of novel diamidines with N-substituents on an amidine N-atom were synthesized and evaluated for their cytotoxicity and in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacterial strains. Based on structure-activity relationship, N-substituents with a branched chain and a shorter carbon chain on the amidine N-atom exhibited more promising activity against Gram-negative and MDR-Gram-positive bacteria; compounds 5c and 5i were the most powerful candidate compounds. Compound 5c showed greater efficacy than levofloxacin against most drug-resistant Gram-positive bacteria and exhibited broad-spectrum antibacterial activity against Gram-negative bacteria, with MIC values in the range of 2-16 μg/mL...
March 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29595093/synergy-of-clavine-alkaloid-chanoclavine-with-tetracycline-against-multi-drug-resistant-e-coli
#17
Gaurav Raj Dwivedi, Anupam Maurya, Dharmendra Kumar Yadav, Vigyasa Singh, Feroz Khan, Mahendra Kumar Gupta, Mastan Singh, Mahendra P Darokar, Santosh Kumar Srivastava
The emergence of multidrug resistance (MDR) in Gram negative bacteria (GNB) and lack of novel classes of antibacterial agents have raised an immediate need to identify antibacterial agents, which can reverse the phenomenon of MDR. The purpose of present study was to evaluate synergy potential and understanding the drug resistance reversal mechanism of chanoclavine isolated from Ipomoea muricata against the multidrug resistant clinical isolate of Escherichia coli (MDREC). Although chanoclavine did not show antibacterial activity of its own, but in combination, it could reduce the minimum inhibitory concentration (MIC) of tetracycline (TET) up to 16 folds...
March 29, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29580299/a-systematic-review-of-the-burden-of-multidrug-resistant-healthcare-associated-infections-among-intensive-care-unit-patients-in-southeast-asia-the-rise-of-multidrug-resistant-acinetobacter-baumannii
#18
Nattawat Teerawattanapong, Pornpansa Panich, Disorn Kulpokin, Siriwat Na Ranong, Khachen Kongpakwattana, Atibodi Saksinanon, Bey-Hing Goh, Learn-Han Lee, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
OBJECTIVETo summarize the clinical burden (cumulative incidence, prevalence, case fatality rate and length of stay) and economic burden (healthcare cost) of healthcare-associated infections (HAIs) due to multidrug-resistant organisms (MDROs) among patients in intensive care units (ICUs) in Southeast Asia.DESIGNSystematic review.METHODSWe conducted a comprehensive literature search in PubMed, EMBASE, CINAHL, EconLit, and the Cochrane Library databases from their inception through September 30, 2016. Clinical and economic burdens and study quality were assessed for each included study...
March 27, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29569910/rational-design-of-dimeric-lysine-n-alkylamides-as-potent-and-broad-spectrum-antibacterial-agents
#19
Youhong Niu, Minghui Wang, Yafei Cao, Alekhya Nimmagadda, Jianxing Hu, Yanfen Wu, Jianfeng Cai, Xin-Shan Ye
Antibiotic resistance is one of the biggest threats to public health, and new antibacterial agents hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Utilizing dimerization strategy, we rationally designed and efficiently synthesized a new series of small molecules-dimeric lysine alkylamides as mimics of AMPs. Evaluation of these mimics against a panel of Gram-positive and Gram-negative bacteria including MDR strains were performed, and a broad-spectrum and potent compound 3d was identified...
March 23, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29567316/evaluation-of-membrane-fluidity-of-multidrug-resistant-isolates-of-escherichia-coli-and-staphylococcus-aureus-in-presence-and-absence-of-antibiotics
#20
Lucinda J Bessa, Mariana Ferreira, Paula Gameiro
In the face of the serious problem of antimicrobial resistance and the global dissemination of multidrug-resistant (MDR) bacteria, it is relevant to deeply study such bacteria both genetically and phenotypically. It is well known that bacteria have the ability to modify the biophysical properties of their cytoplasmic membranes, namely fluidity, in order to survive and thrive in hostile environments. The aim of this study was to assess and compare the membrane fluidity among multidrug-resistant (MDR) isolates of Escherichia coli and Staphylococcus aureus in absence and in presence of antibiotics (ceftazidime or ciprofloxacin)...
March 5, 2018: Journal of Photochemistry and Photobiology. B, Biology
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