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https://www.readbyqxmd.com/read/29223450/pesticide-degrading-natural-multidrug-resistance-bacterial-flora
#1
REVIEW
Kirubakaran Rangasamy, Murugan Athiappan, Natarajan Devarajan, Gopinath Samykannu, Javid A Parray, K N Aruljothi, Nowsheen Shameem, Abdulaziz A Alqarawi, Abeer Hashem, Elsayed Fathi Abd Allah
Multidrug-resistant (MDR) bacteria are a growing threat to humans across the world. Antibiotic resistance is a global problem that has developed through continuous antibiotic use, combinatorial antibiotic use, pesticide-antibiotic cross-resistance, and horizontal gene transfer, as well as various other modes. Pesticide-antibiotic cross-resistance and the subsequent expansion of drug-resistant bacteria are critically documented in this review, the primary focus of which is to assess the impact of indiscriminate pesticide use on the development of microbial communities with parallel pesticide and multidrug resistance...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29209302/influence-of-stress-and-antibiotic-resistance-on-cell-length-distribution-in-mycobacterium-tuberculosis-clinical-isolates
#2
Srinivasan Vijay, Dao N Vinh, Hoang T Hai, Vu T N Ha, Vu T M Dung, Tran D Dinh, Hoang N Nhung, Trinh T B Tram, Bree B Aldridge, Nguyen T Hanh, Do D A Thu, Nguyen H Phu, Guy E Thwaites, Nguyen T T Thuong
Mycobacterial cellular variations in growth and division increase heterogeneity in cell length, possibly contributing to cell-to-cell variation in host and antibiotic stress tolerance. This may be one of the factors influencing Mycobacterium tuberculosis persistence to antibiotics. Tuberculosis (TB) is a major public health problem in developing countries, antibiotic persistence, and emergence of antibiotic resistance further complicates this problem. We wanted to investigate the factors influencing cell-length distribution in clinical M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29206128/conformational-study-of-z-5-4-chlorobenzylidene-2-4-2-hydroxyethyl-piperazin-1-yl-3h-imidazol-4-5h-one-in-different-environments-insight-into-the-structural-properties-of-bacterial-efflux-pump-inhibitors
#3
Ewa Żesławska, Wojciech Nitek, Jadwiga Handzlik
The 2-amine derivatives of 5-arylidene-3H-imidazol-4(5H)-one are a new class of bacterial efflux pump inhibitors, the chemical compounds that are able to restore antibiotic efficacy against multidrug resistant bacteria. 5-Arylidene-3H-imidazol-4(5H)-ones with a piperazine ring at position 2 reverse the mechanisms of multidrug resistance (MDR) of the particularly dangerous Gram-negative bacteria E. coli by inhibition of the efflux pump AcrA/AcrB/TolC (a main multidrug resistance mechanism in Gram-negative bacteria, consisting of a membrane fusion protein, AcrA, a Resistant-Nodulation-Division protein, AcrB, and an outer membrane factor, TolC)...
December 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29206041/lipidated-peptide-dendrimers-killing-multidrug-resistant-bacteria
#4
Thissa N Siriwardena, Michaela Stach, Runze He, Bee-Ha Gan, Sacha Javor, Marc Heitz, Lan Ma, Xiangjun Cai, Peng Chen, Dengwen Wei, Hongtao Li, Jun Ma, Thilo Koehler, Christian van Delden, Tamis Darbre, Jean-Louis Reymond
New antibiotics are urgently needed to address multidrug resistant (MDR) bacteria. Herein we report that second generation (G2) peptide dendrimers bearing a fatty acid chain at the dendrimer core efficiently kill Gram-negative bacteria including Pseudomonas aeruginosa and Acinetobacter baumannii, two of the most problematic MRD bacteria worldwide. Our most active dendrimer TNS18 is also active against Gram-positive methicillin resistant Staphylococcus aureus (MRSA). Based on circular dichroism and molecular dynamics studies we hypothesize that TNS18 adopts a hydrophobically collapsed conformation in water with the fatty acid chain backfolded onto the peptide dendrimer branches, and that the dendrimer unfolds in contact with the membrane to expose its lipid chain and hydrophobic residues, thereby facilitating membrane disruption leading to rapid bacterial cell death...
December 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29205194/analysis-of-beta-lactamases-blandm-1phylogeny-plasmid-replicons-in-multidrug-resistant-klebsiella-spp-from-a-tertiary-care-centre-in-south-india
#5
N Nithya, Rabindran Remitha, P R Jayasree, M Faisal, P R Manish Kumar
BACKGROUND & OBJECTIVES: β-lactamases play a predominant role in drug-resistance amongst Enterobacteriaceae. Presence of genes on transferable plasmids encoding these enzymes favours their dissemination across species and genera within and outside geographical boundaries. This study was aimed to understand the presence of β-lactamases and transferable plasmids in clinical isolates of Klebsiella spp. which can contribute to the spread of resistance determinants. METHODS: A total of 41 clinical isolates of Klebsiella spp...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29203482/presence-of-mcr-3-variant-in-aeromonas-caviae-proteus-mirabilis-and-escherichia-coli-from-one-domestic-duck
#6
Xiaoming Wang, Weishuai Zhai, Jiyun Li, Dejun Liu, Qidi Zhang, Zhangqi Shen, Shaolin Wang, Yang Wang
The rapid rise and dissemination of MDR bacteria is a major threat to public health worldwide, and has narrowed the treatment options for infections caused by these bacteria (1).….
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29186432/bacterial-zincophore-s-s-ethylenediamine-n-n-disuccinic-acid-is-an-effective-inhibitor-of-mbls
#7
Anna Proschak, Jan Kramer, Ewgenij Proschak, Thomas A Wichelhaus
Objectives: Carbapenemases such as MBLs are spreading among Gram-negative bacterial pathogens. Infections due to these MDR bacteria constitute a major global health challenge. Therapeutic strategies against carbapenemase-producing bacteria include β-lactamase inhibitor combinations. [S,S]-ethylenediamine-N,N'-disuccinic acid (EDDS) is a chelator and potential inhibitor of MBLs. We investigated the activity of EDDS in combination with imipenem against MBL-producing bacteria in vitro as well as in vivo...
November 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29184888/targeting-dna-replication-and-repair-for-the-development-of-novel-therapeutics-against-tuberculosis
#8
REVIEW
Michael A Reiche, Digby F Warner, Valerie Mizrahi
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious disease which results in approximately 10 million incident cases and 1.4 million deaths globally each year, making it the leading cause of mortality from infection. An effective frontline combination chemotherapy exists for TB; however, this regimen requires the administration of four drugs in a 2 month long intensive phase followed by a continuation phase of a further 4 months with two of the original drugs, and is only effective for the treatment of drug-sensitive TB...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29182785/antibiotic-therapy-in-neonates-and-impact-on-gut-microbiota-and-antibiotic-resistance-development-a-systematic-review
#9
Jon Widding Fjalstad, Eirin Esaiassen, Lene Kristine Juvet, John N van den Anker, Claus Klingenberg
Objectives: To systematically review the impact of antibiotic therapy in the neonatal period on changes in the gut microbiota and/or antibiotic resistance development. Methods: Data sources were PubMed, Embase, Medline and the Cochrane Database, supplemented by manual searches of reference lists. Randomized controlled trials (RCTs) and observational studies were included if they provided data on different categories of antibiotic treatment (yes versus no, long versus short duration and/or broad- versus narrow-spectrum regimens) and subsequent changes in the gut microbiota and/or antibiotic resistance development...
November 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29177048/impact-of-single-room-design-on-the-spread-of-multi-drug-resistant-bacteria-in-an-intensive-care-unit
#10
Teysir Halaby, Nashwan Al Naiemi, Bert Beishuizen, Roel Verkooijen, José A Ferreira, Rob Klont, Christina Vandenbroucke-Grauls
Background: Cross-transmission of nosocomial pathogens occurs frequently in intensive care units (ICU). The aim of this study was to investigate whether the introduction of a single room policy resulted in a decrease in transmission of multidrug-resistant (MDR) bacteria in an ICU. Methods: We performed a retrospective study covering two periods: between January 2002 and April 2009 (old-ICU) and between May 2009 and March 2013 (new-ICU, single-room). These periods were compared with respect to the occurrence of representative MDR Gram-negative bacteria...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29176850/a-23-year-retrospective-investigation-of-salmonella-typhi-and-salmonella-paratyphi-isolated-in-a-tertiary-kathmandu-hospital
#11
Raphaël M Zellweger, Buddha Basnyat, Poojan Shrestha, Krishna G Prajapati, Sabina Dongol, Paban K Sharma, Samir Koirala, Thomas C Darton, Christiane Dolecek, Corinne N Thompson, Guy E Thwaites, Stephen G Baker, Abhilasha Karkey
BACKGROUND: Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since the early 1990s. Susceptibility against commonly used antimicrobials for treating enteric fever has gradually changed throughout South Asia since this time, posing serious treatment challenges. Here, we aimed to longitudinally describe trends in the isolation of Salmonella enterica and assess changes in their antimicrobial susceptibility in Kathmandu over a 23-year period...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29174699/neoteric-advancement-in-tb-drugs-and-an-overview-on-the-anti-tubercular-role-of-peptides-through-computational-approaches
#12
REVIEW
Ameer Khusro, Chirom Aarti, Alberto Barbabosa-Pliego, Abdelfattah Z M Salem
Tuberculosis (TB) is a devastating threat to human health whose treatment without the emergence of drug resistant Mycobacterium tuberculosis (M. tuberculosis) is the million-dollar question at present. The pathogenesis of M. tuberculosis has been extensively studied which represents unique defence strategies by infecting macrophages. Several anti-tubercular drugs with varied mode of action and administration from diversified sources have been used for the treatment of TB that later contributed to the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB)...
November 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29164074/systemic-responses-of-multidrug-resistant-pseudomonas-aeruginosa-and-acinetobacter-baumannii-following-exposure-to-the-antimicrobial-peptide-cathelicidin-bf-imply-multiple-intracellular-targets
#13
Cunbao Liu, Bin Shan, Jialong Qi, Yanbing Ma
Cathelicidin-BF, derived from the banded krait (Bungarus fasciatus), is a typically cationic, amphiphilic and α-helical antimicrobial peptide (AMP) with 30 amino acids that exerts powerful effects on multidrug-resistant (MDR) clinical isolates, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, but whether it targets plasma membranes or intracellular targets to kill bacteria is still controversial. In the present study, we demonstrated that the disruption of bacterial membranes with high concentrations of cathelicidin-BF was the cause of bacterial death, as with conventional antibiotics at high concentrations...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29161992/stenotrophomonas-maltophilia-causing-blood-stream-infection-in-neonates-and-infants-a-cause-for-concern
#14
Rinku Sah, Shraddha Siwakoti, Ratna Baral, Rupa S Rajbhandari, Basuda Khanal
Stenotrophomonas maltophilia ( S. maltophilia) is an important Gram-negative, non-fermentative, multidrug resistant (MDR) nosocomial organism. We evaluated the isolation of S. maltophilia from the seven blood culture specimens received from the Paediatric Emergency Department (PED) of BP Koirala Institute of Health Sciences (BPKIHS) over the duration of two weeks. The suspicion of a possible outbreak was raised and the hospital infection control team investigated the source and found the hand of one healthcare provider harbouring a similar organism...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29158280/anti-pseudomonal-activity-of-phage-pev20-in-a-dry-powder-formulation-a-proof-of-principle-study-in-a-murine-lung-infection-model
#15
Rachel Yoon Kyung Chang, Ke Chen, Jiping Wang, Martin Wallin, Warwick Britton, Sandra Morales, Elizabeth Kutter, Jian Li, Hak-Kim Chan
Bacteriophage therapy is a promising alternative treatment to antibiotics as it has been documented to be efficacious against multi-drug resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, phage dry powder administration to the lungs has not yet been explored. Powder formulations provide potential advantages over liquid formulation, including easy storage, transport and administration...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29151895/toll-like-receptor-4-differentially-mediates-intestinal-and-extra-intestinal-immune-responses-upon-multi-drug-resistant-pseudomonas-aeruginosa-association-of-il10-mice-with-chronic-colitis
#16
Anne Grunau, Ulrike Escher, Anja A Kühl, Stefan Bereswill, Markus M Heimesaat
Background: Infections with multi-drug resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa (PA) have become a serious threat particularly in hospitalized patients with immunopathological co-morbidities. The well-balanced interplay between immune cells, pattern recognition receptors such as Toll-like receptor (TLR)-4 sensing lipopolysaccharide from Gram-negative bacteria including PA, and evolving pathways is crucial to prevent the host from invading (opportunistic) pathogens...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29142798/verification-of-diagnosis-in-tuberculosis-a-case-report-and-discussion
#17
Amanda M Dave, Abed Adelrahman, Vishist Mehta, Stephen Cavalieri, Renuga Vivekanadan
Tuberculosis (TB), caused by strains of Mycobacterium tuberculosis complex (M. tuberculosis), is a pulmonary infection that is spread by airborne droplet transmission. The development and spread of drug-resistant strains of M. tuberculosisgreatly jeopardize TB control efforts. We report the case of a previously healthy 43-year-old male, visiting from China, who presented to the emergency department complaining of hemoptysis of 10 days' duration. Cultures were positive for acid fast bacteria and negative for fungi...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29136156/increase-in-antimicrobial-resistance-and-emergence-of-major-international-high-risk-clonal-lineages-in-dogs-and-cats-with-urinary-tract-infection-16-year-retrospective-study
#18
Cátia Marques, Adriana Belas, Andreia Franco, Catarina Aboim, Luís Telo Gama, Constança Pomba
Objectives: To evaluate temporal trends in antimicrobial resistance, over 16 years, in bacteria isolated from dogs and cats with urinary tract infection (UTI) and the clonal lineages of bacteria harbouring critical antimicrobial resistance mechanisms. Methods: Antimicrobial susceptibility testing was conducted for 948 bacteria isolated from dogs and cats with UTI (1999-2014). Resistance mechanisms were detected by PCR, namely ESBL/AmpC in third-generation cephalosporin (3GC)-resistant Escherichia coli and Proteus mirabilis, mecA in methicillin-resistant staphylococci, and aac(6')-Ieaph(2″)-Ia and aph(2″)-1d in high-level gentamicin-resistant (HLGR) enterococci...
November 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29116010/multi-drug-resistance-and-extended-spectrum-beta-lactamase-producing-gram-negative-bacteria-from-chicken-meat-in-bharatpur-metropolitan-nepal
#19
Anil Shrestha, Anup Muni Bajracharya, Hemraj Subedi, Raju Shah Turha, Sachin Kafle, Saroj Sharma, Sunil Neupane, Dhiraj Kumar Chaudhary
OBJECTIVE: Multidrug resistance (MDR) and extended spectrum beta lactamase (ESBL) producer Gram negative bacteria are considered as a major health problem, globally. ESBL enzyme hydrolyses the beta lactam ring of third generation cephalosporins, which alters the structure of the antibiotic. Due to the modification in structure of the antibiotic, bacteria show resistance to these antibiotics. Resistant bacterial strains are transmitted to humans from animals through consumption of uncooked meat, through contact with uncooked meat and meat surfaces...
November 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29111435/pharmacodynamics-of-cefiderocol-a-novel-siderophore-cephalosporin-explored-in-a-pseudomonas-aeruginosa-neutropenic-murine-thigh-model
#20
Islam M Ghazi, Marguerite L Monogue, Masakatsu Tsuji, David P Nicolau
BACKGROUND: Cefiderocol is a siderophore cephalosporin that displays potent in vitro activity against multi-drug resistant (MDR) Gram-negative bacteria. We aimed to describe cefiderocol's pharmacokinetics, pharmacodynamics, and 24-hour efficacy using dose-ranging methods in the neutropenic murine thigh infection model. METHODS: Infection was established in neutropenic mice (administered cyclophosphamide 150 mg/kg and 100 mg/kg 4 and 1 days prior to inoculation respectively) with 8 Pseudomonas aeruginosa isolates (MIC range: 0...
October 27, 2017: International Journal of Antimicrobial Agents
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