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https://www.readbyqxmd.com/read/29055132/gram-negative-bacterial-toe-web-infection-a-systematic-review
#1
REVIEW
Till Weidner, Jörg Tittelbach, Tanja Illing, Peter Elsner
Gram-negative bacterial toe web infection (GNBTWI) is a frequent therapeutic challenge in clinical practice with high recurrence rates and frequent need of systemic drugs. The aim of this systematic review was to provide an updated overview and evidence-based data on pathogens, risk-factors and treatment of GNBTWI along with promoting a consistent international terminology. This systematic review is based on a search in PubMed database for English and German articles published between 1980 and 2016. A total of 7 articles were considered appropriate for inclusion in this review regarding to treatment and outcome...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055090/performance-of-nontraditional-hyperglycemia-biomarkers-by-chronic-kidney-disease-status-in-older-adults-with-diabetes-results-from-the-atherosclerosis-risk-in-communities-study
#2
Molly Jung, Bethany Warren, Morgan Grams, Yuenting Diana Kwong, Tariq Shafi, Josef Coresh, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: In persons with chronic kidney disease (CKD), hemoglobin A1c (HbA1c) may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. We investigated associations of HbA1c, glycated albumin, and fructosamine with fasting glucose by CKD categories. METHODS: Cross-sectional analysis of 1,665 Atherosclerosis Risk in Communities Study participants with diagnosed diabetes aged 65 years or older...
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29054951/community-acquired-pseudomonas-aeruginosa-meningitis
#3
Charles Gallaher, James Norman, Abhinav Singh, Frances Sanderson
Gram-negative bacilli such as Pseudomonas aeruginosa are a rare cause of meningitis. Patients developing P. aeruginosa meningitis most commonly have a history of neurosurgical procedures. We report a patient who presented with community-acquired chronic meningitis secondary to P. aeruginosa, related to surgery for otosclerosis 5 years previously.
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054940/rare-presentation-of-an-old-bug
#4
Hasan Ahmad Hasan Albitar, Alice Gallo de Moraes, Kaiser G Lim
We highlight a rare presentation of Legionella infection in a 77-year-old woman with a clinical diagnosis of giant cell arteritis 2 months prior to presentation. She was started on 60 mg prednisone that was tapered to 10 mg after 4 weeks following her diagnosis. She presented with a 1-month progressive dyspnoea in the absence of any other symptoms. Her exposure history was significant only for a recent trip to Florida where she stayed at a hotel. Initial laboratory workup was significant for hyponatraemia (127 mmol/L)...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054908/strange-case-of-dimorphic-skin-rash-in-a-patient-with-cirrhosis-atypical-herpes-simplex-and-sweet-s-syndrome
#5
Cyriac Abby Philips, Rajaguru Paramaguru, Philip Augustine
A middle-aged man with decompensated cirrhosis and a dimorphic multisite skin rash is diagnosed with rare atypical herpes simplex infection, manifesting Sweet's syndrome (SS) in the absence of other described associations. SS, an acute febrile neutrophilic dermatosis, has three common forms-classical or idiopathic, malignancy associated and drug induced. Systemic autoimmune, connective tissue diseases and infections are also strong associations. The latter is commonly described in Gram-positive bacteria, salmonellosis and Yersinia Herpes infections are a rare cause of SS, reported only thrice in literature, one with concomitant lupus, the second with associated mycobacterial infection and third, in metastatic breast disease in contrast to our patient...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054657/feed-additives-shift-gut-microbiota-and-enrich-antibiotic-resistance-in-swine-gut
#6
Yi Zhao, Jian-Qiang Su, Xin-Li An, Fu-Yi Huang, Christopher Rensing, Kristian Koefoed Brandt, Yong-Guan Zhu
Antibiotic resistance genes (ARGs) are emerging environmental contaminants posing a threat to public health. Antibiotics and metals are widely used as feed additives and could consequently affect ARGs in swine gut. In this study, high-throughput quantitative polymerase chain reaction (HT-qPCR) based ARG chip and next-generation 16S rRNA gene amplicon sequencing data were analyzed using multiple statistical approaches to profile the antibiotic resistome and investigate its linkages to antibiotics and metals used as feed additives and to the microbial community composition in freshly collected swine manure samples from three large-scale Chinese pig farms...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054522/antimicrobial-activity-of-a-newly-identified-kazal-type-serine-proteinase-inhibitor-cckpi1-from-the-jellyfish-cyanea-capillata
#7
Yonghong Zhou, Guoyan Liu, Xi Cheng, Qianqian Wang, Bo Wang, Beilei Wang, Hui Zhang, Qian He, Liming Zhang
In this study, we reported a jellyfish-derived Kazal-type serine protease inhibitor, named CcKPI1, from Cyanea capillata. CcKPI1 has a calculated molecular mass of 19.02kDa and contains three typical Kazal domains. Soluble recombinant CcKPI1 (rCcKPI1) was successfully expressed and purified. rCcKPI1 exhibited significant inhibitory activities against elastase, subtilisin A and proteinase K, but not against trypsin or chymotrypsin. Kinetic studies showed that all of the inhibitory effects of rCcKPI1 were competitive, indicating that it may be a microbial serine protease inhibitor and can exhibit antimicrobial activity...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29054298/antimicrobial-resistance-in-community-acquired-urinary-tract-infections-in-paris-in-2015
#8
D Chervet, O Lortholary, J-R Zahar, A Dufougeray, B Pilmis, H Partouche
BACKGROUND: Urinary tract infection (UTI) is one of the most frequent community-acquired infection. Escherichia coli resistance has been on the rise since 2000s. METHODS: We conducted a prospective multicenter cohort study including adults who had a positive urine cytobacteriological examination (UCBE) performed in our Parisian suburb laboratory platform from October 2014 to March 2015. RESULTS: A total of 1223 patients were included: 995 (81...
October 17, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29054028/impact-of-fomesafen-on-the-soil-microbial-communities-in-soybean-fields-in-northeastern-china
#9
Xiao-Hu Wu, Ying Zhang, Peng-Qiang Du, Jun Xu, Feng-Shou Dong, Xin-Gang Liu, Yong-Quan Zheng
Fomesafen, a widely adopted residual herbicide, is used throughout the soybean region of northern China for the spring planting. However, the ecological risks of using fomesafen in soil remain unknown. The aim of this work was to evaluate the impact of fomesafen on the microbial community structure of soil using laboratory and field experiments. Under laboratory conditions, the application of fomesafen at concentrations of 3.75 and 37.5mg/kg decreased the basal respiration (RB) and microbial biomass carbon (MBC)...
October 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29053557/bacterial-keratitis-isolated-organisms-and-antibiotic-resistance-patterns-in-san-francisco
#10
Michelle Y Peng, Vicky Cevallos, Stephen D McLeod, Thomas M Lietman, Jennifer Rose-Nussbaumer
PURPOSE: Understanding the spectrum of pathogens in a given geographic region is important when deciding on empiric antibiotic therapy. In this study, we evaluate the spectrum of bacterial organisms cultured from corneal samples and their antibiotic sensitivities to guide initial treatment of keratitis. METHODS: We performed a retrospective case review of cultures from suspected infectious keratitis cases at the Francis I. Proctor Foundation, University of California, San Francisco, from 1996 through 2015...
October 17, 2017: Cornea
https://www.readbyqxmd.com/read/29053428/dust-bathing-behaviors-of-african-herbivores-and-the-potential-risk-of-inhalational-anthrax
#11
Zoe R Barandongo, John K E Mfune, Wendy C Turner
Anthrax in herbivorous wildlife and livestock is generally assumed to be transmitted via ingestion or inhalation of Bacillus anthracis spores. Although recent studies have highlighted the importance of the ingestion route for anthrax transmission, little is known about the inhalational route in natural systems. Dust bathing could aerosolize soilborne pathogens such as B. anthracis, exposing dust-bathing individuals to inhalational infections. We investigated the potential role of dust bathing in the transmission of inhalational anthrax to herbivorous wildlife in Etosha National Park, Namibia, an area with endemic seasonal anthrax outbreaks...
October 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29053280/structural-and-biochemical-investigation-of-pglf-from-campylobacter-jejuni-reveals-a-new-mechanism-for-a-member-of-the-short-chain-dehydrogenase-reductase-superfamily
#12
Alexander S Riegert, James B Thoden, Ian C Schoenhofen, David C Watson, N Martin Young, Peter A Tipton, Hazel M Holden
Within recent years it has become apparent that protein glycosylation is not limited to eukaryotes. Indeed, in Campylobacter jejuni, a Gram negative bacterium, more than 60 of its proteins are known to be glycosylated. One of the sugars found in such glycosylated proteins is 2,4-diacetamido-2,4,6-trideoxy--d-glucopyranose, hereafter referred to as QuiNAc4NAc. The pathway for its biosynthesis, initiating with UDP-GlcNAc, requires three enzymes referred to as PglF, PglE, and PlgD. The focus of this investigation is on PglF, an NAD+-dependent sugar 4,6-dehydratase known to belong to the short chain dehydrogenase/reductase (SDR) superfamily...
October 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/29053278/it-s-complicated-curvature-diffusion-and-lipid-sorting-within-the-two-membranes-of-escherichia-coli
#13
Pin Chia Hsu, Mohd Firdaus Samsudin, Jonathan Shearer, Syma Khalid
The cell envelope of Gram-negative bacteria is composed of two membranes separated by a soluble region. Here, we report microsecond timescale coarse-grained molecular dynamics simulations of models of the E. coli cell envelope that incorporate both membranes and various native membrane proteins. Our results predict that both the inner and outer membranes curve in a manner dependent on the size of the embedded proteins. The tightly cross-linked lipopolysaccharide molecules (LPS) of the outer membrane cause a strong coupling between the movement of proteins and lipids...
October 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29053263/asymmetric-darzens-reaction-of-isatins-with-diazoacetamides-catalyzed-by-chiral-binol-titanium-complex
#14
Guo-Li Chai, Jian-Wei Han, Henry Nai Ching Wong
An efficient catalytic asymmetric Darzens reaction of N-protected isatins with diazoacetamides using a chiral BINOL/Ti(OiPr)4 complex as the catalyst has been developed. This reaction is a straightforward method for the synthesis of spiro-epoxyoxindoles in 40-95% yields, up to >20:1 dr, and up to >99% ee. A gram-scale reaction was also achieved in 95% yield with excellent stereoselectivity and enantioselectivity (>20:1 dr, >99% ee).
October 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29052670/novel-bis-cyclic-guanidines-as-potent-membrane-active-antibacterial-agents-with-therapeutic-potential
#15
Peng Teng, Alekhya Nimmagadda, Ma Su, Yuzhu Hong, Ning Shen, Chunpu Li, Ling-Yu Tsai, Jessica Cao, Qi Li, Jianfeng Cai
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.
October 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29052416/n-heterocycle-forming-amino-carboperfluoroalkylations-of-aminoalkenes-by-using-perfluoro-acid-anhydrides-mechanistic-studies-and-applications-directed-toward-perfluoroalkylated-compound-libraries
#16
Shintaro Kawamura, Kento Dosei, Elena Valverde, Kiminori Ushida, Mikiko Sodeoka
This work describes a practical and efficient method for synthesizing a diverse array of perfluoroalkylated amines, including N-heterocycles, to afford perfluoroalkylated chemical libraries as potential sources of drug candidates, agrochemicals, and probe molecules for chemical-biology research. Perfluoro acid anhydrides, which are commonly used in organic synthesis, were employed as a perfluoroalkyl source for intramolecular amino- and carbo-perfluoroalkylations of aminoalkenes, affording perfluoroalkylated N-heterocycles, including: aziridines, pyrrolidines, benzothiazinane dioxides, indolines, and hydroisoquinolinones...
October 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29052356/in-vitro-biocompatibility-bioactivity-and-photoluminescence-properties-of-eu-3-sr-2-dual-doped-nano-hydroxyapatite-for-biomedical-applications
#17
Lakshmanaperumal Sundarabharathi, Hemalatha Parangusan, Deepalekshmi Ponnamma, Mariam Al Ali Al-Maadeed, Mahendran Chinnaswamy
In the present investigation, we have successfully synthesized luminescent Eu(3+) -doped and Eu(3+) /Sr(2+) codoped hydroxyapatite (HA) nanoparticles through sol-gel assisted precipitation method with the aim of developing novel biomaterials containing osteoblast mineral (Sr(2+) ) and luminescence activator (Eu(3+) ). The structure, morphology, thermal stability, and luminescence properties of the resultant spherical nanoparticles (50-100 nm diameters) were studied. Moreover, the in-vitro bioactivity of Eu0...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29052060/magnetic-poly-n-isopropylacrylamide-nanocomposites-effect-of-preparation-method-on-antibacterial-properties
#18
Nhung H A Nguyen, Mohamed S A Darwish, Ivan Stibor, Pavel Kejzlar, Alena Ševců
The most challenging task in the preparation of magnetic poly(N-isopropylacrylamide) (Fe3O4-PNIPAAm) nanocomposites for bio-applications is to maximise their reactivity and stability. Emulsion polymerisation, in situ precipitation and physical addition were used to produce Fe3O4-PNIPAAm-1, Fe3O4-PNIPAAm-2 and Fe3O4-PNIPAAm-3, respectively. Their properties were characterised using scanning electron microscopy (morphology), zeta-potential (surface charge), thermogravimetric analysis (stability), vibrating sample magnetometry (magnetisation) and dynamic light scattering...
October 19, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29051936/nio-nanoflakes-grafted-graphene-an-excellent-photocatalyst-and-a-novel-nanomaterial-for-achieving-complete-pathogen-control
#19
A Arshad, J Iqbal, Q Mansoor
The increased levels of industrial pollutants in water and of drug-resistant pathogens more generally are a serious threat to human and aquatic life. Herein, we present the solar-light-induced dye removal and bactericidal properties of nickel oxide (NiO) and graphene nanoplatelet (GNP) nanocomposites. The conducting nature of GNPs is the key factor that accounts for the enhanced photocatalytic and antibacterial activity. Remarkably, the graphene/NiO nanocomposite shows outstanding photocatalytic activity (99% degradation) as compared to NiO (34%) alone, which makes it a potential candidate for the depollution of dye-contaminated water...
October 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/29051762/specific-pathogen-recognition-by-multiple-innate-immune-sensors-in-an-invertebrate
#20
Guillaume Tetreau, Silvain Pinaud, Anaïs Portet, Richard Galinier, Benjamin Gourbal, David Duval
Detection of pathogens by all living organisms is the primary step needed to implement a coherent and efficient immune response. This implies a mediation by different soluble and/or membrane-anchored proteins related to innate immune receptors called PRRs (pattern-recognition receptors) to trigger immune signaling pathways. In most invertebrates, their roles have been inferred by analogy to those already characterized in vertebrate homologs. Despite the induction of their gene expression upon challenge and the presence of structural domains associated with the detection of pathogen-associated molecular patterns in their sequence, their exact role in the induction of immune response and their binding capacity still remain to be demonstrated...
2017: Frontiers in Immunology
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