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https://www.readbyqxmd.com/read/29223115/immobilization-of-hexavalent-chromium-in-contaminated-soils-using-biochar-supported-nanoscale-iron-sulfide-composite
#1
Honghong Lyu, Hang Zhao, Jingchun Tang, Yanyan Gong, Yao Huang, Qihang Wu, Bin Gao
Biochar supported carboxymethyl cellulose (CMC)-stabilized nanoscale iron sulfide (FeS) composite (CMC-FeS@biochar) was prepared and tested for immobilization of hexavalent chromium Cr(VI) in soil. Results of UV-vis and transmission electron microscopy (TEM) showed that the backbone of biochar suppressed the aggregation of FeS, resulting in smaller particle size and more sorption sites than bare FeS. The composite at a dosage of 2.5 mg per gram soil displayed an enhanced Cr(VI) immobilization efficiency (a 94...
December 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29223098/trisubstituted-barbiturates-and-thiobarbiturates-synthesis-and-biological-evaluation-as-xanthine-oxidase-inhibitors-antioxidants-antibacterial-and-anti-proliferative-agents
#2
Joana Figueiredo, João L Serrano, Eunice Cavalheiro, Leena Keurulainen, Jari Yli-Kauhaluoma, Vânia M Moreira, Susana Ferreira, Fernanda C Domingues, Samuel Silvestre, Paulo Almeida
Barbituric and thiobarbituric acid derivatives have become progressively attractive to medicinal chemists due to their wide range of biological activities. Herein, different series of 1,3,5-trisubstituted barbiturates and thiobarbiturates were prepared in moderate to excellent yields and their activity as xanthine oxidase inhibitors, antioxidants, antibacterial agents and as anti-proliferative compounds was evaluated in vitro. Interesting bioactive barbiturates were found namely, 1,3-dimethyl-5-[1-(2-phenylhydrazinyl)ethylidene]pyrimidine-2,4,6(1H,3H,5H)-trione (6c) and 1,3-dimethyl-5-[1-[2-(4-nitrophenyl)hydrazinyl]ethylidene]pyrimidine-2,4,6(1H,3H,5H)-trione (6e), which showed concomitant xanthine oxidase inhibitory effect (IC50 values of 24...
November 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29222980/bonding-of-doxorubicin-to-nanosilica-and-human-serum-albumin-in-various-media
#3
V M Gun'ko, T V Krupska, L S Andriyko, N Yu Klymenko, I V Siora, O A Novikova, A I Marynin, A I Ukrainets, B Charmas, S B Shekhunova, V V Turov
Interaction of doxorubicin hydrochloride (DOX) (anti-cancer drug) with hydro-compacted nanosilica A-300 (cA-300) alone or cA-300/human serum albumin (HSA) at a small content of water (h = 0.4 g per gram of dry silica) in different dispersion media (air, chloroform, and chloroform/trifluoroacetic acid) was analyzed using low-temperature 1H NMR spectroscopy, NMR cryoporometry and quantum chemistry to elucidate specific changes in the interfacial layers. Initial (bulk density ρb ≈ 0.046 g/cm3) and hydro-compacted (ρb ≈ 0...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29222880/consumption-and-sources-of-added-sugar-in-indonesia-a-review
#4
Atmarita, Nelis Imanningsih, Abas B Jahari, Ir Dewi Permaesih, Pauline Chan, Maria Sofia Amarra
BACKGROUND AND OBJECTIVES: The present report summarized the best available evidence regarding consumption level and sources of free or added sugars in Indonesia. METHODS AND STUDY DESIGN: Information was extracted from food balance sheets, household expenditure surveys, nutrition surveys, published studies, unpublished theses/ dissertations, and government reports. RESULTS: A total of 18 references were obtained, showing varying results. Indonesia's national surveys suggested intakes of sugar below 50 grams per day or below 10% of energy intake...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222758/differential-proteomics-based-on-2d-difference-in-gel-electrophoresis-and-tandem-mass-spectrometry-for-the-elucidation-of-biological-processes-in-antibiotic-producer-bacterial-strains
#5
Giuseppe Gallo, Andrea Scaloni
Proteomics based on 2D-Difference In Gel Electrophoresis (2D-DIGE) coupled with mass spectrometry (MS) procedures can be considered a "gold standard" to determine quantitatively and comparatively protein abundances in cell extracts from different biological sources/conditions according to a gel-based approach. In particular, 2D-DIGE is used for protein specie separation, detection, and relative quantification, whenever tandem MS is used to obtain peptide sequence information that is managed according to bioinformatic procedures to identify the differentially represented protein species...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222343/bacterial-cyclic-%C3%AE-1-2-glucans-sequester-iron-to-protect-against-iron-induced-toxicity
#6
Sreegowrinadh Javvadi, Sheo Shankar Pandey, Amita Mishra, Binod Bihari Pradhan, Subhadeep Chatterjee
Cellular iron homeostasis is critical for survival and growth. Bacteria employ a variety of strategies to sequester iron from the environment and to store intracellular iron surplus that can be utilized in iron-restricted conditions while also limiting the potential for the production of iron-induced reactive oxygen species (ROS). Here, we report that membrane-derived oligosaccharide (mdo) glucan, an intrinsic component of Gram-negative bacteria, sequesters the ferrous form of iron. Iron-binding, uptake, and localization experiments indicated that both secreted and periplasmic β-(1,2)-glucans bind iron specifically and promote growth under iron-restricted conditions...
December 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/29222103/a-novel-non-antibiotic-lgt-based-selection-system-for-stable-maintenance-of-expression-vectors-in-escherichia-coli-and-vibrio-cholerae
#7
Manuela Terrinoni, Stefan L Nordqvist, Susanne Källgård, Jan Holmgren, Michael Lebens
Antibiotic selection for maintenance of expression plasmids is discouraged in production of recombinant proteins for pharmaceutical or other human uses due to the risks of antibiotic residue contamination of the final products and release of DNA encoding antibiotic resistance into the environment. We describe the construction of expression plasmids that are instead maintained by complementation of the lgt gene encoding a (pro)lipoprotein glyceryl transferase essential for biosynthesis of bacterial lipoprotein...
December 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29222036/central-and-peripheral-line-associated-bloodstream-infections-in-australian-neonatal-and-paediatric-intensive-care-units-findings-from-a-comprehensive-victorian-surveillance-network-2008-2016
#8
L J Worth, A J Daley, T Spelman, A L Bull, J A Brett, M J Richards
BACKGROUND: Healthcare-associated infections in neonatal and paediatric populations are associated with poorer outcomes and healthcare costs, and surveillance is a necessary component of prevention programs. The objective of this study was to evaluate burden of illness, aetiology, and time-trends for central and peripheral line-associated bloodstream infections (CLABSI and PLABSI) in Australian neonatal and paediatric intensive care units (ICUs) between 1 July 2008 and 31 December 2016...
December 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29222019/a-novel-use-of-cellulose-based-filter-paper-containing-silver-nanoparticles-for-its-potential-application-as-wound-dressing-agent
#9
Adnan Haider, Sajjad Haider, Inn-Kyu Kang, Anuj Kumar, Madhusudana Rao Kummara, Tahseen Kamal, Sung Soo Han
The frequent use of antibiotics against microbial infections may lead the emergence of antibiotic resistant microbial strains. To overcome these microbial strains, we need to fabricate alternative materials which can handle them. It is for this reason, we have fabricated cellulose (CE) based filter paper (FP) composite scaffolds comprising of adsorbed chitosan (CS) and sliver (Ag) nanoparticles (NPs). The AgNPs are incorporated in the CS layer of the composite scaffold. Prior to evaluate the efficacy of the scaffolds against gram positive and gram negative bacterial strains, the scaffolds were characterized for the presence of the Ag NPs with field emission scanning electron microscope (FE-SEM), fourier transform infrared (FTIR) spectroscopy and x-ray diffractometer (XRD)...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221995/antimicrobial-susceptibility-testing-of-colistin-evaluation-of-seven-commercial-mic-products-against-standard-broth-microdilution-for-escherichia-coli-klebsiella-pneumoniae-pseudomonas-aeruginosa-and-acinetobacter-spp
#10
Erika Matuschek, Jenny Åhman, Catherine Webster, Gunnar Kahlmeter
OBJECTIVE: Both EUCAST and CLSI recommend broth microdilution (BMD) for antimicrobial susceptibility testing of colistin, but BMD is rarely used in routine microbiology laboratories. The objective of this study was to evaluate five commercially available BMD products and two brands of gradient tests for colistin MIC determination using BMD according to ISO standard 20776-1 as reference. METHODS: Colistin MIC determination was performed according to the manufacturer's instructions on five commercially available BMD products (Sensititre, MICRONAUT-S, MICRONAUT MIC-Strip, SensiTest and UMIC) and two gradient tests (Etest and MIC Test Strip)...
December 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29221750/secondary-surgical-site-infection-after-coronary-artery-bypass-grafting-a-multi-institutional-prospective-cohort-study
#11
Brian C Gulack, Katherine A Kirkwood, Wei Shi, Peter K Smith, John H Alexander, Sandra G Burks, Annetine C Gelijns, Vinod H Thourani, Daniel Bell, Ann Greenberg, Seth D Goldfarb, Mary Lou Mayer, Michael E Bowdish
OBJECTIVE: To analyze patient risk factors and processes of care associated with secondary surgical-site infection (SSI) after coronary artery bypass grafting (CABG). METHODS: Data were collected prospectively between February and October 2010 for consenting adult patients undergoing CABG with saphenous vein graft (SVG) conduits. Patients who developed a deep or superficial SSI of the leg or groin within 65 days of CABG were compared with those who did not develop a secondary SSI...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221685/role-of-the-ceramide-cd300f-interaction-in-gram-negative-bacterial-skin-infections
#12
Akie Maehara, Ayako Kaitani, Kumi Izawa, Emiko Shiba, Masakazu Nagamine, Ayako Takamori, Masamichi Isobe, Shino Uchida, Koichiro Uchida, Tomoaki Ando, Maeda Keiko, Nobuhiro Nakano, David Voehringer, Axel Roers, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Toshio Kitamura, Jiro Kitaura
No abstract text is available yet for this article.
December 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29220872/new-hydrazide-hydrazones-of-isonicotinic-acid-synthesis-lipophilicity-and-in-vitro-antimicrobial-screening
#13
Łukasz Popiołek, Anna Biernasiuk, Anna Berecka, Anna Gumieniczek, Anna Malm, Monika Wujec
This paper describes the synthesis, lipophilicity and in vitro antimicrobial assays of 15 new hydrazide-hydrazones of isonicotinic acid. New derivatives were obtained on the basis of the condensation reaction of isonicotinic acid hydrazide with different aromatic aldehydes. The chemical structure of synthesized compounds was confirmed by spectral methods. Experimental lipophilicity of new isonicotinic acid derivatives was determined using reversed-phase thin-layer chromatography. All synthesized compounds were subjected to in vitro antimicrobial assays against reference strains of Gram-positive bacteria, Gram-negative bacteria and fungi belonging to Candida spp...
December 8, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29220792/4-quinolone-derivatives-and-their-activities-against-gram-positive-pathogens
#14
Gui-Fu Zhang, Shu Zhang, Baofeng Pan, Xiaofeng Liu, Lian-Shun Feng
Gram-positive bacteria are responsible for a broad range of infectious diseases, and the emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA and MRSE has caused great concern throughout the world. 4-Quinolones which are exemplified by fluoroquinolones are mainstays of chemotherapy against various bacterial infections including Gram-positive pathogen infections, and their value and role in the treatment of bacterial infections continues to expand. However, the resistance of Gram-positive organisms to 4-quinolones develops rapidly and spreads widely, making them more and more ineffective...
November 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220754/association-of-high-mortality-with-extended-spectrum-%C3%AE-lactamase-esbl-positive-cultures-in-community-acquired-infections
#15
Sumit Ray, Dimple Anand, Sankalp Purwar, Arijit Samanta, Kaustubh V Upadhye, Prasoon Gupta, Debashis Dhar
PURPOSE: Infections due to multidrug resistant organisms have become a serious health concern worldwide. The present study was conducted to investigate the spectrum of microbial resistance pattern in the community and their effects on mortality. METHODS: A retrospective review and analysis of prospectively collected data was done of all patients admitted with diagnosis of sepsis in two tertiary care ICU's for a period of two years. Demographics, culture positivity, microbial spectrum, resistance pattern and outcome data were collected...
October 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29220687/development-of-a-novel-functional-core-shell-shell-nanoparticles-from-design-to-anti-bacterial-applications
#16
Nabil Bouazizi, Radhouane Bargougui, Pascal Thebault, Thomas Clamens, Florie Desriac, Flavia Fioresi, Guy Ladam, Sandrine Morin-Grognet, Nadine Mofaddel, Olivier Lesouhaitier, Franck Le Derf, Julien Vieillard
This article reports the synthesis and functionalization of a novel CuO@SiO2-APTES@Ag0 core-shell-shell material using a simple and low-cost process. The growth, design strategies and synthesis approach are the key factors for the development of CuO@SiO2-APTES@Ag0 as efficient material with enhanced antibacterial activity. We investigated the morphology, surface charge, structure and stability of our new core-shell-shell by atomic force microscopy, scanning electron microscopy, energy dispersive X-ray, Fourier transform infrared and UV-visible spectroscopies, zeta potential measurements, and differential scanning calorimetry...
December 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29220644/structure-and-genetics-of-the-o-specific-polysaccharide-of-escherichia-coli-o27
#17
Andrei V Perepelov, Tingting Chen, Sofya N Senchenkova, Andrei V Filatov, Jingjie Song, Alexander S Shashkov, Bin Liu, Yuriy A Knirel
The O-specific polysaccharide (O-antigen) is a part of the lipopolysaccharide on the cell surface of Gram-negative bacteria. The O-polysaccharide was obtained by mild acid hydrolysis of the lipopolysaccharide of Escherichia coli O27 and studied by sugar analysis and Smith degradation along with 1H and 13C NMR spectroscopy. The following structure of the branched hexasaccharide repeating unit was established, which is unique among known structures of bacterial polysaccharides:where GlcA is non-stoichiometrically O-acetylated at position 3 (∼22%) or 4 (∼37%)...
December 2, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29220643/polygenic-risk-for-alcohol-consumption-and-its-association-with-alcohol-related-phenotypes-do-stress-and-life-satisfaction-moderate-these-relationships
#18
Gabry W Mies, Karin J H Verweij, Jorien L Treur, Lannie Ligthart, Iryna O Fedko, Jouke Jan Hottenga, Gonneke Willemsen, Meike Bartels, Dorret I Boomsma, Jacqueline M Vink
BACKGROUND: Genetic and environmental factors contribute about equally to alcohol-related phenotypes in adulthood. In the present study, we examined whether more stress at home or low satisfaction with life might be associated with heavier drinking or more alcohol-related problems in individuals with a high genetic susceptibility to alcohol use. METHODS: Information on polygenic scores and drinking behavior was available in 6705 adults (65% female; 18-83 years) registered with the Netherlands Twin Register...
December 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29220507/assessing-the-heterogeneity-of-in-silico-plasmid-predictions-based-on-whole-genome-sequenced-clinical-isolates
#19
Cedric C Laczny, Valentina Galata, Achim Plum, Andreas E Posch, Andreas Keller
High-throughput next-generation shotgun sequencing of pathogenic bacteria is growing in clinical relevance, especially for chromosomal DNA-based taxonomic identification and for antibiotic resistance prediction. Genetic exchange is facilitated for extrachromosomal DNA, e.g. plasmid-borne antibiotic resistance genes. Consequently, accurate identification of plasmids from whole-genome sequencing (WGS) data remains one of the major challenges for sequencing-based precision medicine in infectious diseases. Here, we assess the heterogeneity of four state-of-the-art tools (cBar, PlasmidFinder, plasmidSPAdes and Recycler) for the in silico prediction of plasmid-derived sequences from WGS data...
December 5, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29220387/psra-controls-the-synthesis-of-the-pseudomonas-aeruginosa-quinolone-signal-via-repression-of-the-fade-homolog-pa0506
#20
Greg Wells, Samantha Palethorpe, Everett C Pesci
Pseudomonas aeruginosa is a ubiquitous, Gram-negative opportunistic pathogen that can cause disease in various sites within the human body. This bacterium is a major source of nosocomial infections that are often difficult to treat due to high intrinsic antibiotic resistance and coordinated virulence factor production. P. aeruginosa utilizes three cell-to-cell signaling systems to regulate numerous genes in response to cell density. One of these systems utilizes the small molecule 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal [PQS]) as a signal that acts as a co-inducer for the transcriptional regulator PqsR...
2017: PloS One
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