keyword
MENU ▼
Read by QxMD icon Read
search

Gram negative infections

keyword
https://www.readbyqxmd.com/read/29351278/analysis-of-the-tonsillar-microbiome-in-young-adults-with-sore-throat-reveals-a-high-relative-abundance-of-fusobacterium-necrophorum-with-low-diversity
#1
T Prescott Atkinson, Robert M Centor, Li Xiao, Fuchenchu Wang, Xiangqin Cui, William Van Der Pol, Casey D Morrow, Amy E Ratliff, Donna M Crabb, Arthur H Totten, Carlos A Estrada, Michael B Faircloth, Ken B Waites
Fusobacterium necrophorum (Fn), a gram-negative anaerobe, is increasingly implicated as an etiologic agent in older adolescents and young adults with sore throat. Inadequately treated Fn pharyngitis may result in suppurative complications such as peritonsillar abscess and Lemierre's syndrome. Data from the literature suggest that the incidence of life-threating complications in these age groups from Fn pharyngitis (Lemierre's syndrome) in the United States exceeds those associated with group A beta-hemolytic streptococcal (GAS) pharyngitis (acute rheumatic fever)...
2018: PloS One
https://www.readbyqxmd.com/read/29350524/development-of-a-multiplexed-microsphere-pcr-for-rapid-culture-free-detection-and-gram-typing-of-bacteria-in-human-blood-samples
#2
Fang Liang, Daniel J Browne, Megan J Gray, Kate H Gartlan, David D Smith, Ross Barnard, Geoff R Hill, Simon Robert Corrie, Kate Markey
Blood stream infection is a significant clinical problem, particularly in vulnerable patient groups such as those undergoing chemotherapy and bone marrow transplantation. Clinical diagnostics for suspected blood stream infection remain centered around blood culture (highly variable timing, hours to days), and empiric use of broad-spectrum antibiotics is often employed for patients presenting with febrile neutropenia. Gram-typing provides the first opportunity to target therapy (e.g. combinations containing vancomycin or teicoplanin for Gram-positives; piperacillin-tazobactam or a carbapenem for Gram-negatives), however current approaches require blood culture...
January 19, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29350201/moth-eye-mimetic-cytocompatible-bactericidal-nanotopography-a-convergent-design
#3
Felipe Viela, Iván Navarro-Baena, Jaime J Hernández, Manuel R Osorio, Isabel Rodriguez
The rapid emergence of antibiotic resistant bacteria has prompted the need for radically different approaches to combat bacterial infections. Among these, bioinspired surface topographies have emerged as an effective sustainable strategy to deter bacterial infection. This study demonstrates the bactericidal activity and cytocompatibility of the moth eye mimetic topography produced by thermal polymer nanoimprinting. The moth eye topography was found to have bactericidal capabilities against Gram negative and Gram positive bacteria...
January 19, 2018: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29349932/isolation-and-characterization-of-lectin-with-antibacterial-antibiofilm-and-antiproliferative-activities-from-acinetobacter-baumannii-of-environmental-origin
#4
Abdullah A Alyousef, Abdulaziz Alqasim, Mustafa Sawsan Aloahd
AIMS: Lectin is a non-immunogenic glycoprotein, have been extracted majority from the plant source primarily leguminoasea. Its ability to precisely recognize and bind to the complex cell bound structure to enable it playing diverse roles. In this study, we obligate to define new sources of lectins since the production of lectins is very expensive. Therefore, we performed a study with the goal to isolate and characterize lectin from bacteria of plant origin and screen its ability as an antibacterial, antibiofilm and antiproliferative agent...
January 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29349040/an-unusual-case-of-primary-melioidotic-prostatic-abscess-complicated-by-perianal-abscess
#5
Y C Chee, Y N Chee
Burkholderia pseudomallei is recognized to cause severe and fatal infections. Most of the infections caused by this facultative intracellular gram-negative bacterium are pneumonia, soft tissue, genito-urinary and central nervous system infection. We report an unusual case of primary prostatic abscess complicated by perianal abscess caused by Burkholderia pseudomallei. Melioidosis related anorectal infections have not been previously reported in the literature.
2018: IDCases
https://www.readbyqxmd.com/read/29348804/lysine-analogue-of-polymyxin-b-as-a-significant-opportunity-for-photodynamic-antimicrobial-chemotherapy
#6
Florent Le Guern, Tan-Sothea Ouk, Catherine Ouk, Regis Vanderesse, Yves Champavier, Emilie Pinault, Vincent Sol
In order to highlight the potential of photodynamic antimicrobial chemotherapy in case of infections by antibiotic resistant-strains, a new antimicrobial peptide conjugate has been synthesized, consisting of a derivative of polymyxin B and a cationic porphyrin covalently attached together to a spacer. A polymyxin-derived moiety was subjected to a primary structural modification in the replacement of four diaminobutyrate residues with lysine ones. This modification was done in order to strongly reduce bactericidal activity, with the aim to eliminate the potential rise of polymyxin-resistant strains...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29348522/in-vitro-and-in-vivo-antimicrobial-activity-of-ts2037-a-novel-aminoglycoside-antibiotic
#7
Yoko Hirai, Kazunori Maebashi, Hideki Fushimi, Yukiko Hiraiwa, Shoichi Murakami, Takayuki Usui, Yoshihisa Akiyama, Nobuto Minowa, Daishiro Ikeda
To overcome serious methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa infections, we synthesized TS2037, 5,4″-diepi-arbekacin, a novel aminoglycoside antibiotic, and evaluated its biological properties. TS2037 showed broad-range, as well as robust antibacterial activities against Gram-positive and Gram-negative bacteria. The MIC50 and MIC90 of TS2037 against clinical isolates of MRSA (n = 54) were both 0.25 µg/mL, and no resistant strain was observed. The MIC50 and MIC90 of TS2037 against clinical isolates of P...
January 18, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29348433/speciation-of-common-gram-negative-pathogens-using-a-highly-multiplexed-high-resolution-melt-curve-assay
#8
Thomas Edwards, Shugo Sasaki, Christopher Williams, Glyn Hobbs, Nicholas A Feasey, Katie Evans, Emily R Adams
The identification of the bacterial species responsible for an infection remains an important step for the selection of antimicrobial therapy. Gram-negative bacteria are an important source of hospital and community acquired infections and frequently antimicrobial resistant. Speciation of bacteria is typically carried out by biochemical profiling of organisms isolated from clinical specimens, which is time consuming and delays the initiation of tailored treatment. Whilst molecular methods such as PCR have been used, they often struggle with the challenge of detecting and discriminating a wide range of targets...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348331/draft-genome-sequences-of-two-vibrio-parahaemolyticus-strains-associated-with-gastroenteritis-after-raw-seafood-ingestion-in-colorado
#9
Sonya A Trinh, Semen A Leyn, Ivan D Rodionov, Adam Godzik, Karla J F Satchell
Vibrio parahaemolyticus is a Gram-negative pathogen associated with gastrointestinal and wound infections after exposure to raw seafood or contaminated waters. We report here the whole-genome sequences of two stool isolates (CDC-AM50933 and CDC-AM43539) from patients in Colorado presenting with gastroenteritis after ingesting raw seafood.
January 18, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29346824/antimicrobial-chemotherapy-has-a-linear-relationship-to-the-proportion-of-gram-negative-isolates-from-pediatric-burn-wounds
#10
Alexa Welk, Myriam Herrnberger, Veronika Engel, Martin Dennebaum, Christina Oetzmann von Sochaczewski, Stephan Gehring
Wound infection in burns is a relevant cause of morbidity and mortality in children. We aimed to determine the relationship between antibacterial chemotherapy and Gram-negative burn wound colonization and infection. All children admitted to the pediatric intensive care unit for burn trauma from June 1, 2005 to January 31, 2013 were included. We obtained 141 wound samples, of which 88 (65.7%) showed growth of Gram-positive bacteria. Treatment with antimicrobial chemotherapy was necessary in 23 (31.1%) patients...
January 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29346648/esrb-negatively-regulates-expression-of-the-glutamine-sythetase-glna-in-the-fish-pathogen-edwardsiella-piscicida
#11
Yunpeng Guan, Kaiyu Yin, Mian Zhou, Minjun Yang, Yuanxing Zhang, Xiaohong Liu, Qiyao Wang
Edwardsiella piscicida is a gram-negative bacterial pathogen invading a wide range of fish species. Response regulator EsrB is essential for activation of type III and type VI secretion systems (T3/T6SS). In this study, proteomes of the wild type E. piscicida EIB202 and a ΔesrB mutant strains were compared to identify the regulon components of EsrB cultured in DMEM allowing T3/T6SS expression. As a result, 19 proteins showed different expression, which were identified to be associated with T3/T6SS, related to amino acid transport and metabolism, and energy production...
January 15, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29345902/flexible-amoxicillin-grafted-bacterial-cellulose-sponges-for-wound-dressing-in-vitro-and-in-vivo-evaluation
#12
Shan Ye, Lei Jiang, Jimin Wu, Chen Su, Chaobo Huang, Xiufeng Liu, Wei Shao
In this study, we report the design and fabrication of a novel biocompatible sponge with excellent antibacterial property, making it a promising material for wound dressings. The sponge is formed by grafting amoxicillin onto regenerated bacterial cellulose (RBC). It was observed that the grafted RBC could enhance the antibacterial activity against fungus, Gram-negative and Gram-positive bacteria. The morphology of strains treated with the grafted RBC and fluorescent stain results further demonstrated the antibacterial ability of the fabricated sponge...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29344356/risk-factors-and-outcomes-for-multidrug-resistant-gram-negative-bacilli-bacteremia
#13
Swati Patolia, Getahun Abate, Nirav Patel, Setu Patolia, Sharon Frey
Background: The incidence of multidrug-resistant (MDR) organisms is increasing along with mortality. Identifying risk factors for the development of MDR Gram-negative bacilli (GNB) bacteremia could greatly impact patient care and management. Methods: Data from the electronic health record of patients with GNB over 13-month period were collected at a single university medical center. Baseline demographic data, risk factor, microbiological data, recurrence of bacteremia, and mortality were recorded...
January 2018: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29344177/characteristics-of-nosocomial-infection-and-its-effects-on-the-survival-of-chemotherapy-patients-with-advanced-non-small-cell-lung-cancer
#14
Lili Wang, Yan Li, Xia Zhang, Hongxia Li
The present study was planned to investigate the characteristics of nosocomial infection and its effects on the survival in advanced non-small cell lung cancer (NSCLC) patients. Retrospective analysis was performed for the 169 chemotherapy patients with NSCLC and nosocomial infection during hospitalization in Binzhou City Central Hospital from March, 2013 to January, 2015. In addition, 170 patients without nosocomial infection were also involved as a control group. The distribution of major drug resistance of Gram-negative (G-) and Gram-positive (G+) were analyzed...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343818/a-surfactant-polymer-dressing-potentiates-antimicrobial-efficacy-in-biofilm-disruption
#15
Piya Das Ghatak, Shomita S Mathew-Steiner, Priyanka Pandey, Sashwati Roy, Chandan K Sen
A 100% water-soluble surfactant polymer dressing (SPD) that is bio-compatible and non-ionic has been reported to improve wound closure in preliminary clinical studies. The mechanism of action of SPD in wound healing remains unclear. Biofilm infection is a significant problem that hinders proper wound closure. The objective of this study was to characterize the mechanism of action of SPD inhibition of bacterial biofilm development. Static biofilms (48 h) of the primary wound pathogens Pseudomonas aeruginosa (PA01), Staphylococcus aureus (USA300) were grown on polycarbonate membranes and treated with SPD with and without antibiotics for an additional 24 h...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343645/crystal-structure-of-the-mammalian-lipopolysaccharide-detoxifier
#16
Alexei Gorelik, Katalin Illes, Bhushan Nagar
LPS is a potent bacterial endotoxin that triggers the innate immune system. Proper recognition of LPS by pattern-recognition receptors requires a full complement of typically six acyl chains in the lipid portion. Acyloxyacyl hydrolase (AOAH) is a host enzyme that removes secondary (acyloxyacyl-linked) fatty acids from LPS, rendering it immunologically inert. This activity is critical for recovery from immune tolerance that follows Gram-negative infection. To understand the molecular mechanism of AOAH function, we determined its crystal structure and its complex with LPS...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29343542/clinical-validation-of-the-sensitest%C3%A2-colistin-a-broth-microdilution-based-method-to-evaluate-colistin-mics
#17
Edoardo Carretto, Flavia Brovarone, Giuseppe Russello, Paola Nardini, Maisra El-Bouseary, Ali Aboklaish, Timothy R Walsh, Jonathan M Tyrrell
The global spread of multi-drug resistant Gram negative has led to the return of colistin for treating severe infections. Recently, different plasmid-mediated genes conferring resistance to this drug were described and reported worldwide. International committees (EUCAST/CLSI) re-evaluated inconsistencies surrounding colistin antimicrobial susceptibility testing (AST), concluding that broth microdilution (BMD) should serve as the reference method for AST. The development of an accurate, reproducible commercial test based on BMD is therefore highly desirable...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29343141/novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-versus-alternative-antibiotics-for-the-treatment-of-complicated-intra-abdominal-infection-and-complicated-urinary-tract-infection-a-meta-analysis-of-randomized-controlled-trials
#18
Mengmeng Chen, Minjie Zhang, Peixian Huang, Qiongyu Lin, Cheng Sun, Hongke Zeng, Yiyu Deng
OBJECTIVES: The aim of this study is to compare the efficacy and safety of novel BL/BLIs with alternative antibiotics for the treatment of Complicated intra-abdominal infection (cIAI) and complicated urinary tract infection (cUTI). METHODS: We performed a systematic review and meta-analysis of all randomized controlled trials comparing novel β-lactam/β-lactamase inhibitors (BL/BLIs) with other antibiotics for the treatment of cIAI and cUTI. The primary outcome included clinical and microbiological treatment success...
January 18, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29341844/empiric-antibiotics-for-sepsis
#19
Sara A Buckman, Isaiah R Turnbull, John E Mazuski
BACKGROUND: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Early recognition and treatment are the cornerstones of management. METHODS: Review of the English-language literature. RESULTS: For both sepsis and septic shock "antimicrobials [should be] be initiated as soon as possible and within one hour" (Surviving Sepsis Campaign). The risk of progression from severe sepsis to septic shock increases 8% for each hour before antibiotics are started...
January 17, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29340455/central-venous-catheter-related-infections-in-patients-receiving-short-term-hemodialysis-therapy-incidence-associated-factors-and-microbiological-aspects
#20
Mayra Gonçalves Menegueti, Natália Cristina Betoni, Fernando Bellissimo-Rodrigues, Elen Almeida Romão
INTRODUCTION: Bloodstream infections are the second most common cause of death among patients on hemodialysis. This study aimed to evaluate the incidence of and risk factors associated with central venous catheter-related infections in patients undergoing hemodialysis, and to identify and characterize the type and antimicrobial susceptibility profiles of the primary microorganisms isolated during one year of follow-up. METHODS: A prospective cohort study was conducted in 2014 in a hemodialysis referral center...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
keyword
keyword
91837
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"