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https://www.readbyqxmd.com/read/27902381/detection-of-escherichia-coli-st131-complex-st705-and-klebsiella-pneumoniae-st15-among-fecal-carriage-of-extended-spectrum-betalactamase-and-carbapenemase-producing-enterobacteriaceae
#1
Esther Rios, Maria Carmen López, Iciar Rodríguez-Avial, Esther Culebras, Juan Jose Picazo
The objective of the present study was to evaluate the prevalence of intestinal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and carbapenemases-producing Enterobacteriaceae (CPE) in non-selected hospitalized and non-hospitalized patients from the same geographic area of Madrid. Among the 501 patients enrolled, 43 (8.6%) carried ESBL-E and 8 (1.6%) patients exhibited CPE. The main intestinal colonizer among ESBL-E was CTX-M-producing Escherichia coli isolates in both settings (community and hospital)...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27894763/extended-spectrum-beta-lactamase-esbl-producing-bacteria-urinary-tract-infections-and-complex-pediatric-urology
#2
Ruth Wragg, Anna Harris, Mitul Patel, Andrew Robb, Harish Chandran, Liam McCarthy
AIM OF THE STUDY: Extended spectrum beta lactamase (ESBL) producing bacteria are resistant to most beta-lactam antibiotics including third-generation cephalosporins, quinolones and aminoglycosides. This resistance is plasmid-borne and can spread between species. Management of ESBL is challenging in children with recurrent urinary tract infections (UTIs) and complex urological abnormalities. We aim to quantify the risk in children and specifically in urological patients. METHODS: Retrospective review of a microbiology database (April 2014 to November 2015)...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27891664/healthcare-costs-doubled-when-children-had-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-bacteria
#3
Oona Nieminen, Matti Korppi, Merja Helminen
AIM: The impact of the emergence of antimicrobial resistant organisms has rarely been studied in children, including the healthcare costs of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria. We evaluated the effect of ESBL on UTI healthcare costs and risk factors for paediatric UTIs. METHODS: This retrospective case-control study covered 2005-2014 and focused on children below 16 years of age treated in a University hospital: 22 children with UTIs caused by ESBL-producing bacteria and 56 ESBL-negative UTI controls...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27890366/in%C3%A2-vitro-biofilm-formation-in-esbl-producing-escherichia-coli-isolates-from-cage-birds
#4
Ebru Sebnem Yılmaz, Nur Ceyhan Güvensen
OBJECTIVE: To determine biofilm and hydrophobicity formation ratios in extended spectrum beta lactamases (ESBL) synthesizing Escherichia coli isolates which were isolated from feces samples of 150 cage bird species randomly taken from pet shops in Hatay province, Turkey. METHODS: In vitro biofilm production of 4 ESBL positive isolates were performed by Congo Red Agar (CRA), Standard Tube (ST) and Microtitre Plate (MP) methods while their hydrophobicity were examined by bacterial adhesion to hydrocarbon (BATH) test...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27889252/peripartum-maternal-transmission-of-extended-spectrum-%C3%AE-lactamase-organism-to-newborn-infants
#5
Avi Peretz, Alina Skuratovsky, Efrat Khabra, Amos Adler, Pastukh Nina, Shay Barak, Yuri Perlitz, Moshe Ben-Ami, Amir Kushnir
The aim of this study was to determine whether the route of extended-spectrum β-lactamase (ESBL) transmission to hospitalized newborns was from their mothers during delivery. Neonatal intensive care unit (NICU) hospitalized newborns were sampled for ESBL presence by stool cultures on the first and fourth days of life. Mothers of ESBL-positive newborns were sampled for possible correlation detection. Bacteria isolates were molecularly identified and susceptibility tests for antibiotic agents were performed...
November 12, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27887765/activity-of-ceftazidime-avibactam-against-multidrug-resistance-enterobacteriaceae-expressing-combined-mechanisms-of-resistance
#6
Inmaculada López-Hernández, Noemí Alonso, Marta Fernández-Martínez, Laura Zamorano, Alba Rivera, Antonio Oliver, M Carmen Conejo, Luis Martínez-Martínez, Ferrán Navarro, Alvaro Pascual
INTRODUCTION: Antimicrobial resistance in Enterobacteriaceae is increasing worldwide and is making treating infections caused by multidrug-resistant Enterobacteriaceae a challenge. The use of β-lactam agents is compromised by microorganisms harboring extended-spectrum β-lactamases (ESBLs) and other mechanisms of resistance. Avibactam is a non β-lactam agent that inhibits clinically relevant β-lactamases, such as ESBL and AmpC. The ceftazidime-avibactam combination (CAZ-AVI) was recently approved for use in certain complicated infections, and may provide a therapeutic alternative for infections caused by these microorganisms...
November 22, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27878781/successful-elimination-of-extended-spectrum-beta-lactamase-esbl-producing-nosocomial-bacteria-at-a-neonatal-intensive-care-unit
#7
Borbála Szél, Zsolt Reiger, Edit Urbán, Andrea Lázár, Krisztina Mader, Ivelina Damjanova, Kamilla Nagy, Gyula Tálosi
BACKGROUND: Extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria are highly dangerous to neonates. At our Neonatal Intensive Care Unit (NICU), the presence of these bacteria became so threatening in 2011 that immediate intervention was required. METHODS: This study was conducted during a nearly two-year period consisting of three phases: retrospective (9 months), educational (3 months) and prospective (9 months). Based on retrospective data analysis, a complex management plan was devised involving the introduction of the INSURE protocol, changes to the antibiotic regimen, microbiological screening at short intervals, progressive feeding, a safer bathing protocol, staff hand hygiene training and continuous monitoring of the number of newly infected and newly colonized patients...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27830191/comparative-genome-analysis-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-sequence-type-131-strains-from-nepal-and-japan
#8
Tohru Miyoshi-Akiyama, Jatan Bahadur Sherchan, Yohei Doi, Maki Nagamatsu, Jeevan B Sherchand, Sarmila Tandukar, Norio Ohmagari, Teruo Kirikae, Hiroshi Ohara, Kayoko Hayakawa
The global spread of extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli (ESBL-E. coli) has largely been driven by the pandemic sequence type 131 (ST131). This study aimed to determine the molecular epidemiology of their spread in two Asian countries with contrasting prevalence. We conducted whole-genome sequencing (WGS) of ESBL-E. coli ST131 strains collected prospectively from Nepal and Japan, two countries in Asia with a high and low prevalence of ESBL-E. coli, respectively. We also systematically compared these genomes with those reported from other regions using publicly available WGS data for E...
September 2016: MSphere
https://www.readbyqxmd.com/read/27816836/characterization-of-ctx-m-enzymes-quinolone-resistance-determinants-and-antimicrobial-residues-from-hospital-sewage-wastewater-treatment-plant-and-river-water
#9
Danieli Conte, Jussara Kasuko Palmeiro, Keite da Silva Nogueira, Thiago Marenda Rosa de Lima, Marco André Cardoso, Roberto Pontarolo, Flávia Lada Degaut Pontes, Libera Maria Dalla-Costa
Multidrug-resistant (MDR) bacteria are widespread in hospitals and have been increasingly isolated from aquatic environments. The aim of the present study was to characterize extended-spectrum β-lactamase (ESBL) and quinolone-resistant Enterobacteriaceae from a hospital effluent, sanitary effluent, inflow sewage, aeration tank, and outflow sewage within a wastewater treatment plant (WWTP), as well as river water upstream and downstream (URW and DRW, respectively), of the point where the WWTP treated effluent was discharged...
November 3, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27815276/genome-dynamics-and-molecular-infection-epidemiology-of-multi-drug-resistant-helicobacter-pullorum-isolates-obtained-from-broiler-and-country-chickens-in-india
#10
Shamsul Qumar, Mohammad Majid, Narender Kumar, Sumeet K Tiwari, Torsten Semmler, Savita Devi, Ramani Baddam, Arif Hussain, Sabiha Shaik, Niyaz Ahmed
: Some of the life-threatening, foodborne, and zoonotic infections are transmitted through poultry birds. Inappropriate and indiscriminate use of antimicrobials in livestock industry has led to increased prevalence of multidrug resistant bacteria of epidemic potentials. Herein, we present the functional molecular epidemiological analysis entailing phenotypic as well as whole genome sequence based characterization of eleven H. pullorum isolates from broiler and free range chickens sampled from retail wet markets of Hyderabad city in India...
November 4, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27815129/reversal-of-resistance-in-bacteria-underlies-synergistic-effect-of-essential-oils-with-conventional-antibiotics
#11
Aida Lahmar, Ahmed Bedoui, Imen Mokdad-Bzeouich, Zaineb Dhaouifi, Zahar Kalboussi, Imed Cheraif, Kamel Ghedira, Leila Chekir-Ghedira
The pervasive of bacterial resistance earnestly threaten the prevention and the treatment of infectious diseases. Therefore, scientific communities take precedence over development of new antimicrobial agents. The aim of the study was to determine antimicrobial potency of three North-African essential oils Pituranthos chloranthus, Teucruim ramosissimum and Pistacia lentiscus individually, and in combination with antibiotics, to inhibit the growth of highly resistant clinical pathogen. Bacteria clinically isolated from patients, subsequently, challenged to a panel of drugs to determine the antibiotic-resistance profiles...
November 2, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27812159/enterobacteriaceae-isolated-from-the-river-danube-antibiotic-resistances-with-a-focus-on-the-presence-of-esbl-and-carbapenemases
#12
Clemens Kittinger, Michaela Lipp, Bettina Folli, Alexander Kirschner, Rita Baumert, Herbert Galler, Andrea J Grisold, Josefa Luxner, Melanie Weissenbacher, Andreas H Farnleitner, Gernot Zarfel
In a clinical setting it seems to be normal these days that a relevant proportion or even the majority of different bacterial species has already one or more acquired antibiotic resistances. Unfortunately, the overuse of antibiotics for livestock breeding and medicine has also altered the wild-type resistance profiles of many bacterial species in different environmental settings. As a matter of fact, getting in contact with resistant bacteria is no longer restricted to hospitals. Beside food and food production, the aquatic environment might also play an important role as reservoir and carrier...
2016: PloS One
https://www.readbyqxmd.com/read/27806830/acquisition-of-extended-spectrum-%C3%AE-lactamases-during-travel-abroad-a-qualitative-study-among-swedish-travellers-examining-their-knowledge-risk-assessment-and-behaviour
#13
Susanne Wiklund, Ingegerd Fagerberg, Åke Örtqvist, Kristina Broliden, Ann Tammelin
BACKGROUND: Travel to foreign countries involves the risk of becoming a carrier of antibiotic-resistant bacteria, especially when the destination is a country with a high prevalence of this type of bacteria. AIM AND METHODS: The aim of this study was to learn about the knowledge of antibiotic resistance, and the behaviour and risk-taking among travellers, who had become carriers of extended spectrum beta-lactamases (ESBL)-producing bacteria during travel to a high-prevalence country...
2016: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/27801378/intestinal-carriage-of-extended-spectrum-beta-lactamase-producing-e-coli-in-women-with-urinary-tract-infections-cameroon
#14
Ingrid Cécile Djuikoue, Paul-Louis Woerther, Michel Toukam, Charles Burdet, Etienne Ruppé, Kamga Hortense Gonsu, Charles Fokunang, Assiya El Mniai, Kamgue Larissa, Anatole Constant Pieme, Mallila Georgia Mboupaing, Caroline Mietchop Kakam, Hervé Kengne Fogang, Antoine Andremont, Jeanne Ngogang
INTRODUCTION: During the last decade, the prevalence of the intestinal carriage of extended spectrum beta-lactamases - producing Escherichia coli (ESBL-E. coli) has continued to increase worldwide in the community, especially in developing countries. Hence, we undertook a study to determine the ESBL-E. coli fecal carriage rate and the associated risk factors in Cameroonian women. METHODOLOGY: A total of 86 women suspected of community-acquired urinary tract infections (UTI) were included in 10 health structures from May 2011 to April 2012...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27795309/esbl-pampc-producing-enterobacteria-in-the-broiler-hatchery-a-mode-of-pseudo-vertical-transmission
#15
Michaela Projahn, Katrin Daehre, Uwe Roesler, Anika Friese
: Antimicrobial resistance through extended-spectrum beta-lactamases (ESBLs) and transferable AmpC beta-lactamases represents an increasing problem in human and veterinary medicine. The presence of ESBL-/pAmpC-producing commensal enterobacteria in farm animals such as broiler chicken is considered as one possible source of food contamination and could, therefore, also be relevant for human colonization. Studies on transmission routes along the broiler production chain showed that already one-day old hatchlings are affected...
October 21, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27794265/molecular-epidemiology-of-environmental-and-clinical-carbapenemase-producing-gram-negative-bacilli-from-hospitals-in-guelma-algeria-multiple-genetic-lineages-and-first-report-of-oxa-48-in-enterobacter-cloacae
#16
Widad Bouguenoun, Sofiane Bakour, Ahmed Aimen Bentorki, Charbel Al Bayssari, Tarek Merad, Jean-Marc Rolain
This study was designed to investigate environmental colonisation in Algerian hospitals by carbapenem-resistant Gram-negative bacilli (GNB), including molecular characterisation of their resistance, and to perform a comparative molecular analysis between clinical and environmental strains. GNB isolated from hospitalised patients and the hospital environment were identified using microbiological methods and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS). Antibiotic susceptibility testing was performed by disk diffusion and Etest methods...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27789683/esbl-ampc-producing-enterobacteriaceae-in-households-with-children-of-preschool-age-prevalence-risk-factors-and-co-carriage
#17
G van den Bunt, A Liakopoulos, D J Mevius, Y Geurts, A C Fluit, M J M Bonten, L Mughini-Gras, W van Pelt
OBJECTIVES: ESBL/AmpC-producing Enterobacteriaceae are an emerging public health concern. As households with preschool children may substantially contribute to the community burden of antimicrobial resistance, we determined the prevalence, risk factors and co-carriage of ESBL/AmpC-producing bacteria in preschool children and their parents. METHODS: From April 2013 to January 2015, each month 2000 preschool children were randomly selected from Dutch population registries...
October 26, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27789039/quantitative-assessment-of-human-exposure-to-extended-spectrum-and-ampc-%C3%AE-lactamases-bearing-e-coli-in-lettuce-attributable-to-irrigation-water-and-subsequent-horizontal-gene-transfer
#18
P M K Njage, E M Buys
The contribution of the fresh produce production environment to human exposure with bacteria bearing extended spectrum β-lactamases and AmpC β-lactamases (ESBL/AmpC) has not been reported. High prevalence of ESBLs/AmpC bearing E. coli as well as a high gene transfer efficiency of lettuce and irrigation water E. coli isolates was previously reported. This stochastic modeling was aimed at quantitatively assessing human exposure to ESBL/AmpC bearing E. coli through lettuce attributable to irrigation water and subsequent horizontal gene transfer...
October 12, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27776162/incidence-clinical-outcome-and-risk-factors-of-intensive-care-unit-infections-in-the-lagos-university-teaching-hospital-luth-lagos-nigeria
#19
Anthony A Iwuafor, Folasade T Ogunsola, Rita O Oladele, Oyin O Oduyebo, Ibironke Desalu, Chukwudi C Egwuatu, Agwu U Nnachi, Comfort N Akujobi, Ita O Ita, Godwin I Ogban
BACKGROUND: Infections are common complications in critically ill patients with associated significant morbidity and mortality. AIM: This study determined the prevalence, risk factors, clinical outcome and microbiological profile of hospital-acquired infections in the intensive care unit of a Nigerian tertiary hospital. MATERIALS AND METHODS: This was a prospective cohort study, patients were recruited and followed up between September 2011 and July 2012 until they were either discharged from the ICU or died...
2016: PloS One
https://www.readbyqxmd.com/read/27771149/esbl-producing-gram-negative-organisms-in-the-healthcare-environment-as-a-source-of-genetic-material-for-resistance-in-human-infections
#20
M Muzslay, G Moore, N Alhussaini, A P R Wilson
BACKGROUND: The increasing prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in the healthcare setting and in the community despite established infection control guidelines indicates that these microorganisms may possess survival strategies that allow them to persist in the environment. AIMS: To determine the extent and variation in endemic ESBL-carrying species in different ward environments, and to investigate the potential for cephalosporin resistance to be transferred from environmental isolates to human pathogens...
September 17, 2016: Journal of Hospital Infection
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