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https://www.readbyqxmd.com/read/28320357/outcome-of-neurological-early-rehabilitation-patients-carrying-multi-drug-resistant-bacteria-results-from-a-german-multi-center-study
#1
J D Rollnik, M Bertram, C Bucka, M Hartwich, M Jöbges, G Ketter, B Leineweber, M Mertl-Rötzer, D A Nowak, T Platz, K Scheidtmann, R Thomas, F von Rosen, C W Wallesch, H Woldag, P Peschel, J Mehrholz, M Pohl
BACKGROUND: Colonization or infection with multi-drug resistant (MDR) bacteria is considered detrimental to the outcome of neurological and neurosurgical early rehabilitation patients. METHODS: In a German multi-center study, 754 neurological early rehabilitation patients were enrolled and and reviewed in respect to MDR status, length of stay (LOS) and the following outcome variables: Barthel Index (BI), Early Rehabilitation Index (ERI), Glasgow Outcome Score Extended (GOSE), Coma Remission Scale (CRS), Functional Ambulation Categories (FAC)...
March 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28318579/antimicrobial-susceptibility-and-characterization-of-extended-spectrum-%C3%AE-lactamases-in-escherichia-coli-isolated-from-bovine-mastitic-milk-in-south-korea-from-2012-to-2015
#2
Dong-Seob Tark, Dong Chan Moon, Hee Young Kang, Su-Ran Kim, Hyang-Mi Nam, Hee-Soo Lee, Suk-Chan Jung, Suk-Kyung Lim
In this study, we aimed to assess trends in antimicrobial resistance and to investigate the characteristics of extended-spectrum β-lactamase (ESBL)-producing isolates from bovine mastitic milk from 2012 to 2015. A total of 374 Escherichia coli isolates were analyzed (154 in 2012, 113 in 2013, 76 in 2014, and 31 in 2015). No consistent trends in antimicrobial resistance of E. coli isolates occurred during the 4-yr period. The most frequently observed resistance was tetracycline (23.3%), followed by streptomycin (17...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28315144/monitoring-antimicrobial-resistance-amr-using-cusum-control-charts
#3
L Righi, R Amarsy, M-Q Picat, M Thuillier, E Cambau, L Raskine, S Chevret, R Flicoteaux
We evaluated the use of the Cumulative Summation (CUSUM) control chart methodology for detection of an excessive increase in antimicrobial-resistant (AMR) bacteria acquisition. We used administrative, clinical and bacteriological data from all 157,570 patients hospitalized for at least 48 h from January 1, 2010 to December 31, 2015 in a 654-bed university teaching hospital in Paris, France. Monthly computed CUSUM were evaluated for the detection of out-of-control situations, defined as incidence rates of acquired AMR bacterial colonization exceeding acceptable thresholds at the hospital and ward levels (based on six selected wards) for AMR bacteria overall and Extended-spectrum beta-lactamases Enterobacteriaceae (ESBL-E) and Methicillin-resistant Staphylococcus aureus (MRSA), specifically...
March 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28288860/epidemiology-of-multidrug-resistant-gram-negative-pathogens-isolated-from-ventilator-associated-pneumonia-in-icu-patients
#4
Richa Gupta, Abida Malik, Meher Rizvi, Moied Ahmed, Anuradha Singh
OBJECTIVES: Antibiotic resistance among Gram-negative pathogens isolated from ventilator-associated pneumonia (VAP) poses a grave threat in intensive care unit (ICU) patients. The aim of this study was to assess the prevalence of pathogens in ICU patients and their drug resistance profile. The prevalence of extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases and metallo-β-lactamases (MBLs) was also assessed. METHODS: Tracheal aspirates were collected aseptically from 87 ICU patients between May 2012 and January 2014...
March 10, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28273621/air-exposure-as-a-possible-route-for-esbl-in-pig-farmers
#5
Wietske Dohmen, Heike Schmitt, Marc Bonten, Dick Heederik
Livestock can carry extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with blaCTX-M-1 being most prevalent. ESBL carriage in farmers is associated with ESBL carriage in animals, with direct animal-human contact considered as the dominant route of transmission. However, inhalation of stable air might represent another route of transmission. We, therefore, quantified presence of blaCTX-M group 1 genes (CTX-M-gr1) in dust and the association with CTX-M-gr1 carriage in pig farmers, family members and employees...
March 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28270849/prevalence-of-extended-spectrum-beta-lactamases-producing-microorganisms-in-patients-admitted-at-krrh-southwestern-uganda
#6
Baguma Andrew, Atek Kagirita, Joel Bazira
The emergence of extended-spectrum beta-lactamase- (ESBL-) producing pathogenic bacteria at Kabale Regional Referral Hospital (KRRH), located in southwestern Uganda, is of great concern: a phenomenon that worries clinicians and other healthcare workers due to the serious threat they pose to patients. This current study aimed at determining the phenotypic detection of ESBL-producing strains of E. coli, Klebsiella sp., and Proteus sp. isolated from clinical specimens and their prevalence in patients admitted at KRRH...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28267783/fecal-carriage-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae-after-urinary-tract-infection-a-three-year-prospective-cohort-study
#7
Silje B Jørgensen, Arne Søraas, Arnfinn Sundsfjord, Knut Liestøl, Truls M Leegaard, Pål A Jenum
We have performed a prospective cohort study to investigate the duration of and risk factors for prolonged fecal carriage of ESBL-producing Escherichia coli or Klebsiella pneumoniae in patients with community acquired urinary tract infection caused by these bacteria. From 2009 to 2011, 101 Norwegian patients were recruited. Stool swabs and questionnaires were collected every three months for one year and at the end of the study in 2012. Information on antibiotic prescriptions was collected from the Norwegian Prescription Database...
2017: PloS One
https://www.readbyqxmd.com/read/28265870/correlation-between-antibiotic-consumption-and-resistance-of-bloodstream-bacteria-in-a-university-hospital-in-north-eastern-italy-2008-2014
#8
Marta Mascarello, Omar Simonetti, Anna Knezevich, Ludovica Ilaria Carniel, Jacopo Monticelli, Marina Busetti, Paolo Schincariol, Lucio Torelli, Roberto Luzzati
PURPOSE: The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS: Antibiotic consumption (Defined Daily Dose-DDD-per 100 patient/days) and antibiotic resistance (percentage of antibiotic intermediate o resistant isolates) were analyzed independently with linear correlation by year...
March 6, 2017: Infection
https://www.readbyqxmd.com/read/28263895/shortening-the-incubation-time-for-antimicrobial-susceptibility-testing-by-disk-diffusion-for-enterobacteriaceae-how-short-can-it-be-and-are-the-results-accurate
#9
Wouter van den Bijllaardt, Anton G Buiting, Johan W Mouton, Anouk E Muller
The standard incubation time for antimicrobial susceptibility testing (AST) by disk diffusion is primarily based on laboratory working hours rather than growth and kill characteristics of bacteria. Faster AST results could result in better patient outcomes and reduced costs by initiating earlier appropriate therapy. The earliest possible reading moment for disk diffusion using established disk zone diameter breakpoints for Enterobacteriaceae was determined with a special focus on the accuracy of the results...
March 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28261951/susceptibility-to-disinfectants-in-antimicrobial-resistant-and-susceptible-isolates-of-escherichia-coli-enterococcus-faecalis-and-enterococcus-faecium-from-poultry-esbl-ampc-phenotype-of-escherichia-coli-is-not-associated-with-resistance-to-a-quaternary-ammonium
#10
Nadine Wieland, Julia Boss, Sarah Lettmann, Barbara Fritz, Karin Schwaiger, Johann Bauer, Christina S Hölzel
AIMS: The spread of bacteria that are simultaneously resistant to disinfectants and antimicrobials would constitute an unsettling scenario. In order to explore an association between antimicrobial resistance and reduced susceptibility to biocides / microbicides like disinfectants in agriculture, we investigated Escherichia (E.) coli (n = 438) and enterococci (n = 120) isolated from six different flocks of the same poultry farm with known history of antimicrobial treatment. METHODS AND RESULTS: Susceptibility to disinfectants (formic acid and a quaternary ammonium compound, didecyldimethlyammoniumchloride - DDAC) was assessed by macrodilution (German Veterinary Society)...
March 6, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28260727/recent-trends-for-the-prevalence-and-transmission-risk-of-extended-spectrum-%C3%AE-lactamases-esbl-producing-bacteria-in-foods
#11
Shiori Yamamoto, Hiroshi Asakura, Shizunobu Igimi
No abstract text is available yet for this article.
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28258755/unexpected-common-occurrence-of-transferable-extended-spectrum-cephalosporinase-producing-escherichia-coli-in-swedish-surface-waters-used-for-drinking-water-supply
#12
Maria Egervärn, Stina Englund, Marianne Ljunge, Christer Wiberg, Maria Finn, Mats Lindblad, Stefan Börjesson
The presence of Enterobacteriaceae producing extended spectrum beta-lactamases (ESBL) or transferable AmpC beta-lactamases (pAmpC) is increasingly being reported in humans, food-producing animals and food world-wide. However, the occurrence and impact of these so-called extended spectrum cephalosporinase (ESC)-producing Enterobacteriaceae in aquatic environments are poorly documented. This study investigated the occurrence, concentrations and characteristics of ESC-producing E. coli (ESC-Ec) in samples of surface water collected at five Swedish water treatment plants that normally have relatively high prevalence and concentration of E...
February 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28257904/in-vitro-activity-of-ceftaroline-and-comparator-agents-against-gram-positive-and-gram-negative-clinical-isolates-from-cancer-patients
#13
Kenneth V I Rolston, Mohamed A Jamal, Lior Nesher, Samuel A Shelburne, Issam Raad, Randall A Prince
Bacterial infections are common in cancer patients. Ceftaroline (CFT) is a broad-spectrum cephalosporin with activity against most Gram-positive organisms (GPOs) and many Gram-negative organisms. In this study, the in vitro activity of CFT was compared with vancomycin (VAN), daptomycin (DAP), linezolid (LZD), trimethoprim/sulphamethoxazole (SXT) and tigecycline (TIG) against bacteria (predominantly blood culture isolates) isolated from cancer patients in 2014 and 2015. CFT was active against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S...
February 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28253356/resistance-to-antimicrobial-drugs-in-different-surface-waters-and-wastewaters-of-guadeloupe
#14
Stéphanie Guyomard-Rabenirina, Celia Dartron, Mélanie Falord, Syndia Sadikalay, Célia Ducat, Vincent Richard, Sébastien Breurec, Olivier Gros, Antoine Talarmin
OBJECTIVE: The first aim of this study was to evaluate the antimicrobial resistance of Enterobacteriaceae in different water environments of Guadeloupe and especially those impacted by waste water treatment plants (WWTP) effluents. The second objective was to characterize the genetic basis for antibiotic resistance of extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producing Enterobacteriaceae isolates (ESBLE and AmpCE). METHODS: We have collected 70 surface waters (river and sea samples) impacted or not by WWTP and 18 waste waters from 2 WWTPs in 2012 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28249582/characteristics-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-isolated-from-fecal-samples-of-piglets-with-diarrhea-in-central-and-southern-taiwan-in-2015
#15
Wan-Chen Lee, Kuang-Sheng Yeh
BACKGROUND: The production of extended-spectrum β-lactamases (ESBLs) confer resistance to the commonly used beta-lactam antimicrobials and ESBL-producing bacteria render treatment difficulty in human and veterinary medicine. ESBL-producing bacteria have emerged in livestock in recent years, which may raise concerns regarding possible transfer of such bacteria through the food chain. The swine industry is important in Taiwan, but investigations regarding the status of ESBL in swine are limited...
March 1, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28249572/efficacy-and-safety-of-de-escalation-therapy-to-ertapenem-for-treatment-of-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-an-open-label-randomized-controlled-trial
#16
Pinyo Rattanaumpawan, Peerawong Werarak, Anupop Jitmuang, Pattarachai Kiratisin, Visanu Thamlikitkul
BACKGROUND: Carbapenem antibiotics are considered the treatment of choice for serious extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria (GNB) infections. The study objectives were to evaluate efficacy and safety of de-escalation therapy to ertapenem for treatment of infections caused by extended-spectrum-β-lactamase-producing Enterobacteriaceae. METHODS: We conducted a randomized controlled trial of adult patients with documented ESBL-producing Enterobacteriaceae infections who had received any group 2 carbapenem for less than 96 h...
March 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28198105/antibiotic-dependent-perturbations-of-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-proteome
#17
Moo-Jin Suh, Sarah L Keasey, Ernst E Brueggemann, Robert G Ulrich
Extended spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-KP) causes life-threatening infections in susceptible and immuno-compromised individuals. Because of the emergence of multidrug resistance and tolerance, it is crucial to better understand the mechanisms by which ESBL-KP can adapt to antibiotic stress. The aim of this study was to provide an overview of the global proteome changes occurring in ESBL-KP in response to sub-lethal concentrations of the antibiotics doxycycline (DC, bacteriostatic) and streptomycin (SM, bactericidal), which both impair ribosomal synthesis of bacterial proteins...
February 15, 2017: Proteomics
https://www.readbyqxmd.com/read/28196696/patients-hospitalized-abroad-as-importers-of-multiresistant-bacteria-a-cross-sectional-study
#18
T Khawaja, J Kirveskari, S Johansson, J Väisänen, A Djupsjöbacka, A Nevalainen, A Kantele
OBJECTIVES: The pandemic spread of multidrug-resistant (MDR) bacteria poses a threat to healthcare worldwide, with highest prevalence in indigent regions of the (sub)tropics. As hospitalization constitutes a major risk factor for colonization, infection control management in low-prevalence countries urgently needs background data on patients hospitalized abroad. METHODS: We collected data on 1122 patients who, after hospitalization abroad, were treated at the Helsinki University Hospital between 2010 and 2013...
February 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28193648/pharmacodynamics-of-finafloxacin-ciprofloxacin-and-levofloxacin-in-serum-and-urine-against-tem-and-shv-type-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-isolated-from-patients-with-urinary-tract-infections
#19
A Dalhoff, S Schubert, A Vente
Background: Pharmacodynamics of finafloxacin, ciprofloxacin and levofloxacin against ESBL-producing Enterobacteriaceae were compared. As quinolones loose activity in acidic media and in particular in urine, their activities were tested in parallel under conventional conditions and in acidic artificial urine.Methods: TEM- and SHV-type ESBL-producing E. coli and K. pneumoniae and their wild-type counterparts were exposed in a modified Grasso model to serum- and urine-concentrations following oral doses of finafloxacin 800mg qd, immediate- release ciprofloxacin 500mg bid, extended release ciprofloxacin-XR 1000mg qd, levofloxacin 500mg qd, or levofloxacin 750mg qd...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167307/fosfomycin-in-vitro-efficacy-against-multidrug-resistant-isolates-beyond-urinary-isolates
#20
Tulin Demir, Tuncay Buyukguclu
OBJECTIVES: Fosfomycin (FOF) is a bactericidal antimicrobial agent active against a range of Gram-negative bacteria, including multidrug-resistant (MDR) and metallo-β-lactamase (MBL)-producing Enterobacteriaceae. However, data are scarce regarding use of the drug beyond urinary tract infections (UTIs). METHODS: In this study, susceptibility rates to FOF among 290 MDR Enterobacteriaceae isolates were analysed by gradient and disk diffusion tests and the results were compared with agar dilution according to the Clinical and Laboratory Standards Institute (CLSI)...
February 3, 2017: Journal of Global Antimicrobial Resistance
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