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https://www.readbyqxmd.com/read/29330015/mother-to-child-transmission-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae
#1
Dana Danino, Rimma Melamed, Batya Sterer, Nurith Porat, Guy Hazan, Alex Gushanski, Eilon Shany, David Greenberg, Avraham Borer
BACKGROUND: Preterm infants are at high risk for extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to maternal-neonatal transmission. However, there is no consensus regarding surveillance of pregnant women for ESBL-E colonization. AIM: To identify pairs of mothers and offspring harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants...
January 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29324655/evaluation-of-an-accelerated-workflow-for-surveillance-of-esbl-ctx-m-producing-escherichia-coli-using-amplicon-based-next-generation-sequencing-and-automated-analysis
#2
Nilay Peker, John W A Rossen, Ruud H Deurenberg, Paula C Langereis, Erwin G C Raangs, Jan A Kluytmans, Alexander W Friedrich, Jacobien Veenemans, Bhanu Sinha
Outbreak management of extended spectrum β-lactamase (ESBL)-producing pathogens requires rapid and accurate diagnosis. However, conventional screening is slow and labor-intensive. The vast majority of the screened samples are negative and detection of non-outbreak-related resistant micro-organisms often complicates outbreak management. In a CTX-M-15-producing Escherichia coli outbreak, 149 fecal samples and rectal eSwabs were collected by a cross-sectional survey in a Dutch nursing home. Samples were processed by routine diagnostic methods...
January 11, 2018: Microorganisms
https://www.readbyqxmd.com/read/29322334/detection-of-%C3%AE-lactamase-encoding-genes-in-feces-soil-and-water-from-a-brazilian-pig-farm
#3
João Pedro Rueda Furlan, Eliana Guedes Stehling
β-lactam antibiotics are widely used for the treatment of different types of infections worldwide and the resistance to these antibiotics has grown sharply, which is of great concern. Resistance to β-lactams in gram-negative bacteria is mainly due to the production of β-lactamases, which are classified according to their functional activities. The aim of this study was to verify the presence of β-lactamases encoding genes in feces, soil, and water from a Brazilian pig farm. Different β-lactamases encoding genes were found, including blaCTX-M-Gp1, blaCTX-M-Gp9, blaSHV, blaOXA-1-like, blaGES, and blaVEB...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29322236/-urosepsis
#4
Mathias W Pletz, Sebastian Weis, Christina Forstner, Florian Wagenlehner
Urosepsis is defined as a severe disease due to organ failure caused by a urinary tract infection. An empirical antibiotic therapy should be instigated within the first hour after diagnosis. Urine cultures and blood cultures should be performed before antibiotic treatment. Further diagnostics should be carried out at an early stage to enable an interventional focus control in the case of urinary tract obstruction or abscess formation, if necessary. Gram-negative pathogens are most frequently isolated. Extended spectrum beta-lactamase (ESBL) forming bacteria as a cause of urosepsis are increasing...
January 10, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29316517/functional-metagenomics-reveals-a-novel-carbapenem-hydrolyzing-mobile-beta-lactamase-from-indian-river-sediments-contaminated-with-antibiotic-production-waste
#5
Nachiket P Marathe, Anders Janzon, Stathis D Kotsakis, Carl-Fredrik Flach, Mohammad Razavi, Fanny Berglund, Erik Kristiansson, D G Joakim Larsson
Evolution has provided environmental bacteria with a plethora of genes that give resistance to antibiotic compounds. Under anthropogenic selection pressures, some of these genes are believed to be recruited over time into pathogens by horizontal gene transfer. River sediment polluted with fluoroquinolones and other drugs discharged from bulk drug production in India constitute an environment with unprecedented, long-term antibiotic selection pressures. It is therefore plausible that previously unknown resistance genes have evolved and/or are promoted here...
January 6, 2018: Environment International
https://www.readbyqxmd.com/read/29312660/high-prevalence-of-esbl-producing-e-coli-in-private-and-shared-latrines-in-an-informal-urban-settlement-in-dar-es-salaam-tanzania
#6
Stefan Erb, Lauren D'Mello-Guyett, Hamisi M Malebo, Robert M Njee, Fatuma Matwewe, Jeroen Ensink, Vladimira Hinic, Andreas Widmer, Reno Frei
Background: Data about the burden of extended-spectrum beta-lactamase (ESBL)-producing microorganisms in Africa are limited. Our study aimed to estimate the prevalence of human faecal ESBL carriage in the community of an informal urban settlement in Dar es Salaam (Tanzania, East Africa) by using environmental contamination of household latrines with ESBL as a surrogate marker. Methods: Within the context of a large survey in February 2014 assessing 636 randomly selected household latrines for faecal contamination by the detection of growth of E...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29305512/molecular-epidemiology-of-dairy-cattle-associated-escherichia-coli-carrying-blactx-m-genes-in-washington-state
#7
Josephine A Afema, Sara Ahmed, Thomas E Besser, Lisa P Jones, William M Sischo, Margaret A Davis
An increase in prevalence of commensal Escherichia coli carrying blaCTX-M genes among dairy cattle was observed between 2008 and 2012 in Washington State. To study the molecular epidemiology of this change, we selected 126 blaCTX-M-positive and 126 blaCTX-M-negative isolates for multi-locus sequence typing (MLST) and antibiotic resistance phenotyping from E. coli obtained during a previous study. For 99 isolates we also determined the blaCTX-M alleles using PCR and sequencing and identified the replicon types of blaCTX-M carrying plasmids...
January 5, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29304312/high-prevalence-and-temporal-variation-of-extended-spectrum-%C3%AE-lactamase-producing-bacteria-in-urban-swedish-mallards
#8
Jon Hessman, Clara Atterby, Björn Olsen, Josef D Järhult
Antibiotic resistant bacteria present a growing global healthcare challenge. Previous research demonstrates that wild birds harbor extended spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and may contribute to their dissemination. We aimed to assess prevalence and temporal variation in the detection rate of ESBL-producing bacteria in urban wild birds and to evaluate methods regarding sample handling. Monthly fecal sampling was performed in 2013 at an urban pond in Sweden. ESBL-producing Escherichia coli and Klebsiella pneumoniae were analyzed by polymerase chain reaction targeting blaCTX-M...
January 5, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29304069/naso-and-oropharyngeal-bacterial-carriage-in-nursing-home-residents-impact-of-multimorbidity-and-functional-impairment
#9
Anja Kwetkat, Wolfgang Pfister, Diana Pansow, Mathias W Pletz, Cornel C Sieber, Heike Hoyer
OBJECTIVE: From April 2013 to February 2014 we performed a multicentre prospective cross-sectional study in 541 German nursing home residents. We determined pharyngeal carriage of Streptococcus pneumoniae (primary objective) and other bacteria (secondary objective) in naso- and oropharyngeal swabs by culture-based standard procedures and explored the influence of multimorbidity and functional status on bacterial carriage. METHODS: Socio-demographic data, vaccination status, multimorbidity, nutrition and functional status defined by Comprehensive Geriatric Assessment were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29290482/first-report-on-extended-spectrum-beta-lactamase-esbl-producing-escherichia-coli-from-european-free-tailed-bats-tadarida-teniotis-in-portugal-a-one-health-approach-of-a-hidden-contamination-problem
#10
Andreia Garcês, Susana Correia, Francisco Amorim, José Eduardo Pereira, Gilberto Igrejas, Patrícia Poeta
The main aim of this study was to characterize the diversity of extended-spectrum beta-lactamases (ESBLs) in Escherichia coli isolates from European free tailed-bats (Tadarida teniotis) in Portugal. ESBL-producing E. coli isolates were recovered from 14 of 146 faecal samples (9.6%) and a total of 19 isolates were completely characterized. The more prevalent beta-lactamase genes detected were blaCTX-M-1 (57.9%) and blaCTX-M-3 (36.8%), followed by blaSHV (31.6%), blaTEM (21.1%), blaOXA (10.5%) and blaCTX-M-9 (10...
December 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29284053/esbl-producing-escherichia-coli-in-swedish-gulls-a-case-of-environmental-pollution-from-humans
#11
Clara Atterby, Stefan Börjesson, Sofia Ny, Josef D Järhult, Sara Byfors, Jonas Bonnedahl
ESBL-producing bacteria are present in wildlife and the environment might serve as a resistance reservoir. Wild gulls have been described as frequent carriers of ESBL-producing E. coli strains with genotypic characteristics similar to strains found in humans. Therefore, potential dissemination of antibiotic resistance genes and bacteria between the human population and wildlife need to be further investigated. Occurrence and characterization of ESBL-producing E. coli in Swedish wild gulls were assessed and compared to isolates from humans, livestock and surface water collected in the same country and similar time-period...
2017: PloS One
https://www.readbyqxmd.com/read/29259134/computational-antimicrobial-peptide-design-and-evaluation-against-multidrug-resistant-clinical-isolates-of-bacteria
#12
Deepesh Nagarajan, Tushar Nagarajan, Natasha Roy, Omkar Kulkarni, Sathyabaarathi Ravichandran, Madhulika Mishra, Dipshikha Chakravortty, Nagasuma Chandra
There is a pressing need for new therapeutics to combat multi-drug and carbapenem-resistant bacterial pathogens. This challenge prompted us to use a long short-term memory (LSTM) language model to understand the underlying grammar, i.e. the arrangement and frequencies of amino acid residues, in known antimicrobial peptide sequences. According to the output of our LSTM network, we synthesized 10 peptides and tested them against known bacterial pathogens. All of these peptides displayed broad-spectrum antimicrobial activity, validating our LSTM-based peptide design approach...
December 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29250038/double-serine-fluoroquinolone-resistance-mutations-advance-major-international-clones-and-lineages-of-various-multi-drug-resistant-bacteria
#13
REVIEW
Miklos Fuzi, Dora Szabo, Rita Csercsik
The major international sequence types/lineages of methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and ESBL-producing E. coli were demonstrated to have been advanced by favorable fitness balance associated with high-level resistance to fluoroquinolones. The paper shows that favorable fitness in the major STs/lineages of these pathogens was principally attained by the capacity of evolving mutations in the fluoroquinolone-binding serine residues of both the DNA gyrase and topoisomerase IV enzymes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237787/point-counterpoint-piperacillin-tazobactam-should-be-used-to-treat-infections-with-esbl-positive-organisms
#14
Audrey Schuetz, Sergio Reyes Salcedo, Pranita D Tamma
Beta-lactam/beta-lactamase inhibitor combinations (BLBLIs) are among the most controversial classes of antibiotic agents available for the treatment of infections caused by extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria (ESBL-GNR). Piperacillin-tazobactam (PTZ) is one of the most frequently utilized antibiotic agents for empiric gram-negative bacterial coverage and remains active against a large proportion of ESBL-GNR. Furthermore, good antimicrobial stewardship practices encourage the use of carbapenem-sparing treatment regimens for infections due to ESBL-GNR...
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29224318/-distribution-and-drug-resistance-of-pathogens-of-blood-stream-infection-in-patients-with-hematological-malignancies-after-chemotherapy
#15
S Z Chen, K N Lin, M Xiao, X F Luo, Q Li, J H Ren, R Y Huang, M M Chen, Z Z Ally, T Chen, J D Yang, Jianda Hu
Objective: To investigate the distribution and resistance of pathogens isolated from blood cultures in patients with hematological malignancies after chemotherapy in Union Hospital of Fujian Medical University so as to understand the real situation of blood stream infection (BSI) and provide the basis for rational use of antibiotics in clinic. Methods: The data of 657 strains isolated from blood culture specimens of patients with hematological malignancies from January 2013 to December 2016 were collected analyzed...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29215863/near-infrared-laser-excited-nanoparticles-to-eradicate-multidrug-resistant-bacteria-and-promote-wound-healing
#16
Yue Qiao, Fei Ma, Chao Liu, Bo Zhou, Qiaolin Wei, Wanlin Li, Danni Zhong, Yangyang Li, Min Zhou
With the ever-growing threat of bacterial infections, especially for multidrug-resistant microbial infections, the development of highly effective treatment modalities to inhibit the infections is challenging. Although silver nanoparticles have been intensively applied as an antimicrobial agent for decades, the therapeutic efficacy towards multidrug-resistant bacteria is still unsatisfactory. Here, we show that near-infrared (NIR) laser-excited silver triangular nanoparticles (Tri-Ag) can efficiently kill Gram-negative Escherichia coli (E...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29209306/ctx-m-15-producing-e-coli-isolates-from-food-products-in-germany-are-mainly-associated-with-an-incf-type-plasmid-and-belong-to-two-predominant-clonal-e-coli-lineages
#17
Alexandra Irrgang, Linda Falgenhauer, Jennie Fischer, Hiren Ghosh, Elisabet Guiral, Beatriz Guerra, Silvia Schmoger, Can Imirzalioglu, Trinad Chakraborty, Jens A Hammerl, Annemarie Käsbohrer
Extended-spectrum beta-lactamases (ESBL) mediating resistance to 3rd generation cephalosporins are a major public health issue. As food may be a vehicle in the spread of ESLB-producing bacteria, a study on the occurrence of cephalosporin-resistantu Escherichia coli in food was initiated. A total of 404 ESBL-producing isolates were obtained from animal-derived food samples (e.g., poultry products, pork, beef and raw milk) between 2011 and 2013. As CTX-M-15 is the most abundant enzyme in ESBL-producing E. coli causing human infections, this study focusses on E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29205194/analysis-of-beta-lactamases-blandm-1phylogeny-plasmid-replicons-in-multidrug-resistant-klebsiella-spp-from-a-tertiary-care-centre-in-south-india
#18
N Nithya, Rabindran Remitha, P R Jayasree, M Faisal, P R Manish Kumar
BACKGROUND & OBJECTIVES: β-lactamases play a predominant role in drug-resistance amongst Enterobacteriaceae. Presence of genes on transferable plasmids encoding these enzymes favours their dissemination across species and genera within and outside geographical boundaries. This study was aimed to understand the presence of β-lactamases and transferable plasmids in clinical isolates of Klebsiella spp. which can contribute to the spread of resistance determinants. METHODS: A total of 41 clinical isolates of Klebsiella spp...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29201522/clinical-effect-of-discordance-in-empirical-treatment-of-cases-with-urinary-tract-infection-accompanied-by-bacteremia
#19
İlyas Dökmetaş, Aziz Ahmad Hamidi, Mehmet Emin Bulut, Sinan Çetin, Ahsen Öncül, Nuray Uzun
Objective: It has been shown in previous studies that inadequate empirical treatment is associated with mortality in a variety of infections caused by Gram-negative bacteria. In this study, the clinical effect of discordance in empirical treatment was investigated in patients with urinary tract infection (UTI) accompanied by bacteremia. Material and methods: We retrospectively reviewed the files of adult (>18 years old) patients who were diagnosed with UTI in our clinic between January 2014 and December 2015...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29193166/multiplex-identification-of-sepsis-causing-gram-negative-pathogens-from-the-plasma-of-infected-blood
#20
Boram Chung, Chulmin Park, Sung-Yeon Cho, Juyoun Shin, Sun Shin, Seon-Hee Yim, Dong-Gun Lee, Yeun-Jung Chung
Early and accurate detection of bacterial pathogens in the blood is the most crucial step for sepsis management. Gram-negative bacteria are the most common organisms causing severe sepsis and responsible for high morbidity and mortality. We aimed to develop a method for rapid multiplex identification of clinically important Gram-negative pathogens and also validated whether our system can identify Gram-negative pathogens with the cell-free plasm DNA from infected blood. We designed five MLPA probe sets targeting the genes specific to major Gram-negative pathogens (uidA and lacY for E...
November 28, 2017: Electrophoresis
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