Marisa Flook, Elena Rojano, Alvaro Gallego-Martinez, Alba Escalera-Balsera, Patricia Perez-Carpena, M Del Carmen Moleon, Rocio Gonzalez-Aguado, Victoria Rivero de Jesus, Emilio Domínguez-Durán, Lidia Frejo, Juan A G Ranea, Jose Antonio Lopez-Escamez
Meniere Disease (MD) is a chronic inner ear disorder characterized by vertigo attacks, sensorineural hearing loss, tinnitus, and aural fullness. Extensive evidence supporting the inflammatory etiology of MD has been found, therefore, by using transcriptome analysis, we aim to describe the inflammatory variants of MD. We performed Bulk RNAseq on 45 patients with definite MD and 15 healthy controls. MD patients were classified according to their basal levels of IL-1β into 2 groups: high and low. Differentially expression analysis was performed using the ExpHunter Suite, and cell type proportion was evaluated using the estimation algorithms xCell, ABIS, and CIBERSORTx...
February 23, 2024: Genes and Immunity