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https://www.readbyqxmd.com/read/28780186/dynamic-forces-over-the-interface-between-a-seated-human-body-and-a-rigid-seat-during-vertical-whole-body-vibration
#1
Chi Liu, Yi Qiu, Michael J Griffin
Biodynamic responses of the seated human body are usually measured and modelled assuming a single point of vibration excitation. With vertical vibration excitation, this study investigated how forces are distributed over the body-seat interface. Vertical and fore-and-aft forces were measured beneath the ischial tuberosities, middle thighs, and front thighs of 14 subjects sitting on a rigid flat seat in three postures with different thigh contact while exposed to random vertical vibration at three magnitudes...
July 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28771825/mercury-bioavailability-transformations-and-effects-to-freshwater-biofilms
#2
REVIEW
Perrine Dranguet, Séverine Le Faucheur, Vera I Slaveykova
Mercury (Hg) compounds represent an important risk to aquatic ecosystems due to their persistence, bioaccumulation and biomagnification potential. In the present review, we critically examine the state-of-the-art studies concerning the interactions of Hg compounds with freshwater biofilms with emphasis on Hg accumulation, transformations and effects. Freshwater biofilms contain both primary producers (e.g. algae) and decomposers (e.g bacteria and fungi), which contribute to both aquatic food webs and microbial loop...
August 3, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28767802/parathyroidectomy-in-chronic-kidney-disease-effects-on-weight-gain-and-on-quality-of-life-improvement
#3
Henyse Gomes Valente-Da-Silva, Maria Cristina Araújo Maya, Annie Seixas Moreira
Objective: to evaluate the benefit of parathyroidectomy in patients on hemodialysis, regarding nutritional and biochemical statuses, body composition and the health-related quality of life. Methods: this is a longitudinal study involving 28 hemodialysis adult patients with severe secondary hyperparathyroidism evaluated before and one year after surgery. Inclusion criteria: parathyroid hormone levels exceeding ten times the upper normal range and end-stage renal disease in hemodialysis program...
May 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28714791/influence-of-body-composition-on-functional-movement-screen%C3%A2-scores-in-collegiate-football-players
#4
Constantine P Nicolozakes, Daniel K Schneider, Ben Rower, James Borchers, Timothy E Hewett
CONTEXT: The Functional Movement Screen (FMS™) is used to identify movement asymmetries and deficiencies. While obesity has been reported to impede movement, the correlation between body mass index (BMI), body fat percentage (BF%), and FMS™ in athletes is unknown. OBJECTIVE: To determine if there is a relationship between BMI, BF%, and FMS™ scores in a sample of National Collegiate Athletic Association (NCAA) Division I football athletes. DESIGN: Cross-sectional study...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28682597/the-effect-of-microplastic-on-the-uptake-of-chemicals-by-the-lugworm-arenicola-marina-l-under-environmentally-relevant-exposure-conditions
#5
Ellen Besseling, Edwin M Foekema, Martine J van den Heuvel-Greve, Albert A Koelmans
It has been hypothesized that ingestion of microplastic increases exposure of aquatic organisms to hydrophobic contaminants. To date, most laboratory studies investigated chemical transfer from ingested microplastic without taking other exposure pathways into account. Therefore, we studied the effect of polyethylene (PE) microplastic in sediment on PCB uptake by Arenicola marina as a model species, quantifying uptake fluxes from all natural exposure pathways. PCB concentrations in sediment, biota lipids (Clip) and porewater measured with passive samplers were used to derive lipid-normalized bioaccumulation metrics Clip, Biota sediment accumulation factor (BSAF), Bioaccumulation factor (BAF) and the Biota plastic accumulation factor (BPAF)...
August 1, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28667686/pulsatile-crizotinib-treatment-for-brain-metastasis-in-a-patient-with-non-small-cell-lung-cancer
#6
S Wang, J Chen, Z Xie, L Xia, W Luo, J Li, Q Li, Z Yang
WHAT IS KNOWN AND OBJECTIVE: Anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) is a distinct subtype with patients showing peculiar clinicopathological features and dramatic responses to the ALK tyrosine kinase inhibitor crizotinib. Patients with this cancer variant have a dismal prognosis and limited treatment options when it has progressed to intracranial metastasis because of inadequate drug penetration into the central nervous system (CNS). Factors associated with response to TKI therapy have been reported to include pharmacokinetic and biodynamic resistance phenomena...
June 30, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28589284/evaluation-on-subcellular-partitioning-and-biodynamics-of-pulse-copper-toxicity-in-tilapia-reveals-impacts-of-a-major-environmental-disturbance
#7
Yun-Ru Ju, Ying-Fei Yang, Jeng-Wei Tsai, Yi-Hsien Cheng, Wei-Yu Chen, Chung-Min Liao
Fluctuation exposure of trace metal copper (Cu) is ubiquitous in aquatic environments. The purpose of this study was to investigate the impacts of chronically pulsed exposure on biodynamics and subcellular partitioning of Cu in freshwater tilapia (Oreochromis mossambicus). Long-term 28-day pulsed Cu exposure experiments were performed to explore subcellular partitioning and toxicokinetics/toxicodynamics of Cu in tilapia. Subcellular partitioning linking with a metal influx scheme was used to estimate detoxification and elimination rates...
July 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28569068/genetic-characterization-of-periphyton-communities-associated-with-selenium-bioconcentration-and-trophic-transfer-in-a-simple-food-chain
#8
Vanessa Friesen, Lorne E Doig, Blue E Markwart, Monique Haakensen, Emily Tissier, Karsten Liber
A major source of uncertainty in predicting selenium (Se) distribution in aquatic food webs lies in the enrichment factor (EF), the ratio of Se bioconcentration in primary producers and microorganisms relative to the concentration of Se in the surrounding water. It has been well demonstrated that EFs can vary dramatically among individual algal taxa, but data are lacking regarding the influence of periphyton community composition on EFs for a given geochemical form of Se. Therefore, the goals of this study were first to assess whether different periphyton communities could be established in aquaria with the same starting inoculum using different light and nutrient regimes, and second, to determine if the periphyton assemblage composition influences the uptake of waterborne Se (as selenite) and subsequent Se transfer to a model macroinvertebrate primary consumer...
June 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28538593/dynamic-response-of-the-lumbar-spine-to-whole-body-vibration-under-a-compressive-follower-preload
#9
Li-Xin Guo, Wei Fan
STUDY DESIGN: A finite element study of dynamic response of the lumbar spine to whole-body vibration. OBJECTIVE: To develop and validate a finite element model for exploring the impact of whole-body vibration on the entire lumbar spine with a compressive follower preload applied. SUMMARY OF BACKGROUND DATA: Several finite element studies have investigated the biodynamic characteristics of the human lumbar spine when exposed to whole-body vibration...
May 22, 2017: Spine
https://www.readbyqxmd.com/read/28414545/modular-use-of-human-body-models-of-varying-levels-of-complexity-validation-of-head-kinematics
#10
William Decker, Bharath Koya, Matthew L Davis, F Scott Gayzik
OBJECTIVE: The significant computational resources required to execute detailed human body finite-element models has motivated the development of faster running, simplified models (e.g., GHBMC M50-OS). Previous studies have demonstrated the ability to modularly incorporate the validated GHBMC M50-O brain model into the simplified model (GHBMC M50-OS+B), which allows for localized analysis of the brain in a fraction of the computation time required for the detailed model. The objective of this study is to validate the head and neck kinematics of the GHBMC M50-O and M50-OS (detailed and simplified versions of the same model) against human volunteer test data in frontal and lateral loading...
May 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28371562/amnion-epithelial-cells-promote-lung-repair-via-lipoxin-a4
#11
Jean L Tan, Yan Z Tan, Ruth Muljadi, Siow T Chan, Sin N Lau, Joanne C Mockler, Euan M Wallace, Rebecca Lim
Human amnion epithelial cells (hAECs) have been shown to possess potent immunomodulatory properties across a number of disease models. Recently, we reported that hAECs influence macrophage polarization and activity, and that this step was dependent on regulatory T cells. In this study, we aimed to assess the effects of hAEC-derived proresolution lipoxin-A4 (LXA4) on T-cell, macrophage, and neutrophil phenotype and function during the acute phase of bleomycin-induced lung injury. Using C57Bl6 mice, we administered 4 million hAECs intraperitoneally 24 hours after bleomycin challenge...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28361424/role-of-prolactin-in-the-regulation-of-bicarbonates-biodynamics-in-female-rat-model-of-cholestasis-of-pregnancy
#12
O A Bulaeva, P A Abramicheva, T A Balakina, O V Smirnova
We studied possible involvement of prolactin in the regulation of bicarbonate biodynamics using female rat model of cholestasis of pregnancy induced by transplantation of the donor pituitary under the renal capsule of a recipient (hyperprolactinemia) and bile duct ligation (cholestasis). The concentration of bicarbonates in the bile and blood, their excretion, clearance, and reabsorption, as well as glomerular filtration rate and excretion of sodium ions were assessed. It was found that the main effect of prolactin was directed to the kidney-regulated pool of bicarbonates and consisted in stimulation of their clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration...
March 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28301634/biodynamic-imaging-for-phenotypic-profiling-of-three-dimensional-tissue-culture
#13
Hao Sun, Daniel Merrill, Ran An, John Turek, Daniela Matei, David D Nolte
No abstract text is available yet for this article.
January 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28286038/multi-stimuli-responsive-biohybrid-nanoparticles-with-cross-linked-albumin-coronae-self-assembled-by-a-polymer-protein-biodynamer
#14
Lin Wang, Li Liu, Bingyang Dong, Hanying Zhao, Mingming Zhang, Wenjuan Chen, Yanhang Hong
A thermoresponsive polymer-protein biodynamer was prepared via the bioconjugation of an aliphatic aldehyde-functionalized copolymer to hydrazine-modified bovine serum albumin (BSA) through reversible pyridylhydrazone linkages. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and size exclusion chromatography (SEC) results indicated that the pyridylhydrazone linkages cleaved in an intracellular-mimicking acidic milieu, thus leading to the release of BSA. The dynamic character of the protein biodynamer was demonstrated by exchange reactions with aldehyde-containing molecules...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28264145/human-body-modeling-method-to-simulate-the-biodynamic-characteristics-of-spine-in-vivo-with-different-sitting-postures
#15
Rui-Chun Dong, Li-Xin Guo
The aim of this study is to model the computational model of seated whole human body including skeleton, muscle, viscera, ligament, intervertebral disc, and skin to predict effect of the factors (sitting postures, muscle and skin, buttocks, viscera, arms, gravity, and boundary conditions) on the biodynamic characteristics of spine. Two finite element models of seated whole body and a large number of finite element models of different ligamentous motion segments were developed and validated. Static, modal, and transient dynamic analyses were performed...
March 6, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28204900/cadmium-bioaccumulation-in-aquatic-oligochaetes-using-a-biodynamic-model-a-review-of-values-of-physiological-parameters-and-model-validation-using-laboratory-and-field-bioaccumulation-data
#16
REVIEW
Leire Méndez-Fernández, Pilar Rodriguez, Maite Martínez-Madrid
This study reviews certain physiological digestive parameters in the literature that could be used to predict tissue residues in aquatic oligochaetes using the biodynamic model. Predictions were evaluated with independently measured Cd bioaccumulation data in sediment bioassays and field oligochaetes. The parameter review focused on three species commonly used in ecotoxicity testing and bioaccumulation studies: Tubifex tubifex (Tt), Limnodrilus hoffmeisteri (Lh) and Lumbriculus variegatus (Lv). Median Ingestion rates (g g(-1) d(-1), dw) at unpolluted conditions were 7...
2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28195714/predicting-partitioning-and-diffusion-properties-of-nonpolar-chemicals-in-biotic-media-and-passive-sampler-phases-by-gc-%C3%A3-gc
#17
Deedar Nabi, J Samuel Arey
The chemical parameters needed to explain and predict bioavailability, biodynamics, and baseline toxicity are not readily available for most nonpolar chemicals detected in the environment. Here, we demonstrate that comprehensive two-dimensional gas chromatography (GC × GC) retention times can be used to predict 26 relevant properties for nonpolar chemicals, specifically: partition coefficients for diverse biotic media and passive sampler phases; aquatic baseline toxicity; and relevant diffusion coefficients...
March 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28169527/molecular-biodynamers-dynamic-covalent-analogues-of-biopolymers
#18
Yun Liu, Jean-Marie Lehn, Anna K H Hirsch
Constitutional dynamic chemistry (CDC) features the use of reversible linkages at both molecular and supramolecular levels, including reversible covalent bonds (dynamic covalent chemistry, DCC) and noncovalent interactions (dynamic noncovalent chemistry, DNCC). Due to its inherent reversibility and stimuli-responsiveness, CDC has been widely utilized as a powerful tool for the screening of bioactive compounds, the exploitation of receptors or substrates driven by molecular recognition, and the fabrication of constitutionally dynamic materials...
February 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28113692/admittance-adaptive-model-based-approach-to-mitigate-biodynamic-feedthrough
#19
Joost Venrooij, Max Mulder, Mark Mulder, David A Abbink, Marinus M van Paassen, Frans C T van der Helm, Heinrich H Bulthoff
Biodynamic feedthrough (BDFT) refers to the feedthrough of vehicle accelerations through the human body, leading to involuntary control device inputs. BDFT impairs control performance in a large range of vehicles under various circumstances. Research shows that BDFT strongly depends on adaptations in the neuromuscular admittance dynamics of the human body. This paper proposes a model-based approach of BDFT mitigation that accounts for these neuromuscular adaptations. The method was tested, as proof-of-concept, in an experiment where participants inside a motion simulator controlled a simulated vehicle through a virtual tunnel...
September 12, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28089465/differential-bioaccumulation-patterns-of-nanosized-and-dissolved-silver-in-a-land-snail-achatina-fulica
#20
Yuanzhen Chen, Youbin Si, Dongmei Zhou, Fei Dang
With the increasing application in antimicrobial products, silver nanoparticles (AgNP) are inevitably released into the terrestrial environment, and pose potential risks to invertebrates such as land snails Achatina fulica, which take up AgNP from food and water. Here we differentiate Ag uptake biodynamic between Ag forms (i.e., PVP-AgNP vs. AgNO3) and between exposure pathways. Snails assimilated Ag efficiently from lettuce leaves pre-exposed to AgNP, with assimilation efficiencies (AEs) averaging 62-85% and food ingestion rates of 0...
March 2017: Environmental Pollution
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