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anti hla dq antibodies

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https://www.readbyqxmd.com/read/27826602/a-novel-method-for-anti-hla-antibody-detection-using-personalized-peptide-arrays
#1
Pan Liu, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, Jing Jin
BACKGROUND: HLA mismatches are the primary cause of alloantibody-mediated rejection (AMR) in organ transplantation. To delineate antigenic and immunogenic potentials among individual HLA mismatches, information regarding antibody specificity at the epitope level, instead of the allelic level, is needed. METHODS: This study explores a direct screening method for HLA linear epitopes in kidney transplant patients. We custom synthesized a large panel of 15-residue HLA peptides in an array format and measured alloantibody reactivity to these peptides from the sera of post and/or pretransplant patients...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27742303/hyperacute-rejection-in-a-kidney-transplant-with-negative-crossmatch-a-case-report
#2
M Pereira, J Guerra, J Gonçalves, A Santana, C Nascimento, A G da Costa
Hyperacute rejection (HAR) is a rare event that can be prevented by crossmatch tests that detect anti-human leukocyte antigen antibodies against the donor. We present the case of a 43-year-old man who underwent a deceased-donor kidney transplantation with a negative complement-dependent cytotoxicity and a negative flow cytometry crossmatch. Luminex technology detected anti-DQ donor-specific antibodies (DSA) with a mean fluorescence intensity of 11,000. A single plasmapheresis session was carried out, followed by immunosuppression with immunoglobulin, antithymocyte globulin, tacrolimus, and methylprednisolone...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27630850/prevalence-of-autoantibodies-and-hla-dr-dq-in-type-1-diabetes-mellitus
#3
Shailja Singh, Usha, Gyanendra Singh, Neeraj Kumar Agrawal, Rana Gopal Singh, Shashi Bhushan Kumar
INTRODUCTION: Type I diabetes Mellitus (T1DM) is caused by autoimmune destruction of β-cells of pancreas. Two forms of T1DM are known called as 1A (autoimmune) and 1B (idiopathic). AIM: Aim was to study the prevalence of Anti-TTG IgA, Anti-TPO, GADA, ZnT8 and IA-2 autoantibodies and HLA DR and DQ genes and its diagnostic value in T1DM. MATERIALS AND METHODS: Thirty four T1DM patients, 59 type 2 diabetes mellitus (T2DM) patients and 28 healthy controls were included in study...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27569927/association-of-c1q-binding-status-with-de-novo-hla-antibody-clinical-features-and-allograft-function-in-kidney-transplantation-patients-during-eight-years-of-dynamic-follow-up
#4
X Wei, X Yuan, M Sun, Z Pan, L Hu, L Wang, J He, J Hou
BACKGROUND: C1q-binding donor-specific antibody (DSA) is detrimental to transplanted kidney function. However, the factors that affect C1q binding status are unclear. METHODS: A total of 519 samples from 129 consecutive kidney transplantation patients during 8 years of dynamic follow-up were collected for HLA antibody (Ab) screening and C1q detection. RESULTS: Among the detected HLA Abs, the majority were class II, and the DQ subtypes composed the highest proportion...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27487045/anti-zinc-transporter-protein-8-antibody-testing-is-not-informative-in-routine-prediabetes-screening-in-young-patients-with-autoimmune-thyroiditis-and-celiac-disease
#5
Daniela Larizza, Mara De Amici, Catherine Klersy, Michela Albanesi, Riccardo Albertini, Carla Badulli, Cristina Torre, Valeria Calcaterra
BACKGROUND/AIMS: Patients with type 1 diabetes mellitus (T1DM), autoimmune thyroiditis (ATD), and celiac disease (CD) are at increased risk for developing other autoimmune diseases. We evaluated zinc transporter 8 (ZnT8) prevalence in patients with ATD and/or CD in order to define the usefulness of ZnT8 autoantibodies for prediabetes screening. METHODS: Eighty-one young patients with ATD and/or CD were included in the study; 32 subjects with clinical onset of T1DM were enrolled as a control group...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27131886/the-prevalence-of-celiac-disease-in-patients-with-geographic-tongue
#6
Livia Cigic, Tea Galic, Darko Kero, Miroslav Simunic, Ivana Medvedec Mikic, Danijela Kalibovic Govorko, Dolores Biocina Lukenda
BACKGROUND: Geographic tongue (GT) is a benign inflammatory condition usually involving the dorsal surface and lateral borders of the tongue. Numerous etiological factors of GT have been suggested, including immunological factors; genetic; atopic or allergic predisposition; emotional stress; and hormonal disturbances. GT may also coexist as one of the possible manifestations of celiac disease (CD). Therefore, the aim of this study was to investigate the prevalence of CD, positive serologic tests for CD screening, and HLA-DQ presence in patients with GT...
May 1, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/26967790/de-novo-dq-donor-specific-antibodies-are-associated-with-chronic-lung-allograft-dysfunction-after-lung-transplantation
#7
Jussi M Tikkanen, Lianne G Singer, S Joseph Kim, Yanhong Li, Matthew Binnie, Cecilia Chaparro, Chung-Wai Chow, Tereza Martinu, Sassan Azad, Shaf Keshavjee, Kathryn Tinckam
RATIONALE: Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear. OBJECTIVES: To describe the incidence, characteristics, and impact of dnDSA after lung transplantation. METHODS: We investigated a single-center cohort of 340 lung transplant recipients undergoing transplant during 2008 to 2011...
September 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26818121/association-of-hla-dq-alleles-with-the-presence-of-an-anti-%C3%AE-2-glycoprotein-i-antibody-in-patients-with-recurrent-miscarriage
#8
X Chen, P-Y Liang, G-G Li, L-H Diao, C-C Liu, C-Y Huang, T-H Wu, J Xu, Y Zeng
Immunogenetic studies have suggested that autoantibody production is commonly associated with particular human leukocyte antigens (HLA) class II genotypes in certain autoimmune diseases. The objective of this study was to investigate whether the production of anti-β2-glycoprotein I antibody (aβ2GPI) was associated with particular HLA-DQ alleles in patients with recurrent miscarriage (RM). The HLA-DQ genotypes in 126 patients with RM were determined using the polymerase chain reaction-sequence-specific primer method...
January 2016: HLA
https://www.readbyqxmd.com/read/26796677/-immunological-monitoring-in-kidney-transplantation-13%C3%A2-years-experience-of-a-moroccan-histocompatibility-laboratory
#9
C Brick, O Atouf, M Essakalli
PURPOSE OF STUDY: The quality of the immunological monitoring is crucial because it determines the success of the kidney transplantation. The scope of this work is to describe the experience of the department of immunological unity of the Ibn Sina university hospital in Rabat regarding the immunological monitoring of patients transplanted between 2001 and 2014. PATIENTS AND METHODS: Patient samples were collected from nephrology services of different public and private hospitals of Morocco...
May 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/26729543/prevalence-of-adult-celiac-disease-in-india-regional-variations-and-associations
#10
COMPARATIVE STUDY
B S Ramakrishna, Govind K Makharia, Kamal Chetri, Sangitanjan Dutta, Prashant Mathur, Vineet Ahuja, Ritvik Amarchand, Ramadass Balamurugan, Sudipta D Chowdhury, Dolly Daniel, Anup Das, Gemlyn George, Siddhartha Datta Gupta, Anand Krishnan, Jasmin H Prasad, Gurvinder Kaur, Srinivasan Pugazhendhi, Anna Pulimood, Kartik Ramakrishna, Anil K Verma
OBJECTIVES: Although celiac disease (CeD) affects 1% of people in the northern part of India, it is believed to be uncommon in the southern and northeastern parts because of significant differences in dietary pattern and ethnicity. We estimated the prevalence of CeD in these three populations. In a subset, we also investigated differences in the prevalence of HLA-DQ 2/8 allelotype and dietary grain consumption. METHODS: A total of 23,331 healthy adults were sampled from three regions of India-northern (n=6207), northeastern (n=8149), and southern (n=8973)-and screened for CeD using IgA anti-tissue transglutaminase antibody...
January 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26636737/de-novo-anti-hla-dsa-characteristics-and-subclinical-antibody-mediated-kidney-allograft-injury
#11
Takayuki Yamamoto, Yoshihiko Watarai, Asami Takeda, Makoto Tsujita, Takahisa Hiramitsu, Norihiko Goto, Shunji Narumi, Akio Katayama, Kunio Morozumi, Kazuharu Uchida, Takaaki Kobayashi
BACKGROUND: It is unclear whether all donor-specific antibodies (DSA) can cause chronic antibody-mediated rejection (AMR). Subclinical stage before manifestation of renal dysfunction may be a critical period for reversing AMR. The aim of our study was to identify factors related to the development of subclinical AMR and to clarify the characteristics of de novo DSA. METHODS: Eight hundred ninety-nine renal transplants were screened for HLA antibody. De novo DSA were detected in 95 patients...
October 2016: Transplantation
https://www.readbyqxmd.com/read/26594008/association-of-hla-dq-alleles-with-the-presence-of-an-anti-%C3%AE-2-glycoprotein-i-antibody-in-patients-with-recurrent-miscarriage
#12
X Chen, P-Y Liang, G-G Li, L-H Diao, C-C Liu, C-Y Huang, T-H Wu, J Xu, Y Zeng
Immunogenetic studies have suggested that autoantibody production is commonly associated with particular human leukocyte antigens (HLA) class II genotypes in certain autoimmune diseases. The objective of this study was to investigate whether the production of anti-β2 -glycoprotein I antibody (aβ2 GPI) was associated with particular HLA-DQ alleles in patients with recurrent miscarriage (RM). The HLA-DQ genotypes in 126 patients with RM were determined using the polymerase chain reaction-sequence-specific primer method...
November 23, 2015: Tissue Antigens
https://www.readbyqxmd.com/read/26372979/-anti-nep-and-anti-pla2r-antibodies-in-membranous-nephropathy-an-update
#13
REVIEW
A A Pozdzik, H Debiec, I Brochériou, C Husson, S Rorive, N Broeders, A Le Moine, P Ronco, J Nortier
Membranous nephropathy (MN) is the most common cause for nephrotic syndrome in adults and occurs as an idiopathic (primary) or secondary disease. Since the early 2000's, substantial advances have been made in the understanding of the molecular bases of MN. The neutral endopeptidase (NEP) and the receptor for secretory phospholipase A2 (PLA2R) have been identified as target antigens for circulating and deposited antibodies in allo-immune neonatal and adult " idiopathic " MN, respectively. These antibodies recognize specific antigens of podocytes, precipitate as subepithelial immune complexes and activate complement leading to proteinuria...
May 2015: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/26262501/deleterious-impact-of-donor-specific-anti-hla-antibodies-toward-hla-cw-and-hla-dp-in-kidney-transplantation
#14
COMPARATIVE STUDY
Thomas Bachelet, Charlie Martinez, Arnaud Del Bello, Lionel Couzi, Salima Kejji, Gwendaline Guidicelli, Sébastien Lepreux, Jonathan Visentin, Nicolas Congy-Jolivet, Lionel Rostaing, Jean-Luc Taupin, Nassim Kamar, Pierre Merville
BACKGROUND: It is widely accepted that HLA donor-specific antibodies (DSA) are associated with antibody-mediated rejection and graft loss. However, in many transplant programs, preformed anti-HLA-Cw and anti-HLA-DP DSA are not considered in organ allocation policies because their clinical relevance is still uncertain. METHODS: We analyzed the clinical impact of Cw/DP DSA through a retrospective study, comparing 48 patients transplanted with isolated preformed Cw/DP DSA (Cw/DP DSA group) with (i) 104 matched HLA-sensitized kidney transplant recipients with No DSA at D0 (No DSA group) and (ii) 47 kidney transplant recipients with preformed A, -B, -DR, -DQ DSA (A/B/DR/DQ DSA group)...
January 2016: Transplantation
https://www.readbyqxmd.com/read/26036480/effect-of-different-sensitization-events-on-hla-alloimmunization-in-kidney-transplantation-candidates
#15
D Lopes, T Barra, J Malheiro, S Tafulo, L Martins, M Almeida, S Pedroso, L Dias, A Castro Henriques, A Cabrita
BACKGROUND: HLA alloimmunization is caused by sensitization events (SEs), such as transfusion, pregnancy, or previous organ transplantation, and the effects of particular SEs have not been thoroughly studied. Our aim was to evaluate how each SE affected HLA alloimmunization by considering Luminex assays. METHODS: Sera from 722 kidney transplantation candidates were screened per protocol by means of Luminex assays to determine the presence of anti-HLA class I/II antibodies; positive sera underwent single-antigen assay to determine the presence of specific antibodies against HLA A, B, C, DR, DQ, DP loci (positivity if median fluorescence intensity values were >1,000)...
May 2015: Transplantation Proceedings
https://www.readbyqxmd.com/read/26031594/a-refractory-case-of-subclinical-antibody-mediated-rejection-due-to-anti-hla-dq-antibody-in-a-kidney-transplant-patient
#16
Toshinari Fujimoto, Yasuyuki Nakada, Izumi Yamamoto, Akimitsu Kobayashi, Yudo Tanno, Hiroki Yamada, Jun Miki, Ichiro Ohkido, Nobuo Tsuboi, Hiroyasu Yamamoto, Takashi Yokoo
We herein report a refractory case of subclinical antibody-mediated rejection (AMR) due to anti-HLA-DQ antibody in a kidney transplant patient. A 45-year-old man was admitted for a protocol biopsy; he had a serum creatinine (S-Cr) level of 1.8 mg/dL 3 years following primary kidney transplantation. Histological examination revealed moderate to severe inflammatory cell infiltration in the peritubular capillaries. Thorough laboratory examination showed that the patient had donor-specific antibodies (DSAbs) to DR9 and DQ9...
July 2015: Nephrology
https://www.readbyqxmd.com/read/26014903/hla-dpb1-variant-rs3117242-is-associated-with-anti-neutrophil-cytoplasmic-antibody-associated-vasculitides%C3%A2-in-a-han-chinese-population
#17
Ziyan Wu, Qingjun Wu, Juanjuan Xu, Si Chen, Fei Sun, Ping Li, Yina Bai, Wenjie Zheng, Hua Chen, Fengchun Zhang, Yongzhe Li
AIM: The vasculitis diseases granulomatosis with polyangiitis (GPA) and microscopic polyangitis (MPA) are the two major forms of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). A recent genome-wide association study has shown that the genes HLA-DPB1 and HLA-DQ conferred susceptibility to GPA and MPA, respectively. We investigated the linkage between putative AAV-related genes (HLA-DPB1, ARHGAP18, CD226, CTLA-4, MOSPD2 and PRTN3) and AAV in a Han Chinese population...
May 27, 2015: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/25987262/humoral-immune-response-and-allograft-function-in-kidney-transplantation
#18
REVIEW
Edward J Filippone, John L Farber
HLA antibodies can damage a kidney transplant. In January 2013, consensus guidelines from The Transplantation Society were published regarding technical aspects of HLA antibody determination, as well as their potential significance in the pre- and posttransplantation periods. During the past 2 years, new studies have been reported, but controversies remain. In this article, these new data related to HLA antibodies in kidney transplantation are reviewed and compared to relevant prior research. Pretransplantation sensitization issues are discussed, including the new more sensitive assays (flow cytometry and solid-phase immunoassays such as Luminex single-antigen bead assays)...
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/25976621/anti-human-leukocyte-antigen-dq-antibodies-in-renal-transplantation-are-we-underestimating-the-most-frequent-donor-specific-alloantibodies
#19
REVIEW
Paolo Carta, Lorenzo Di Maria, Leonardo Caroti, Elisa Buti, Giulia Antognoli, Enrico Eugenio Minetti
The role of anti-human leukocyte antigens DQ region (HLA-DQ) in transplantation is historically less studied than HLA-DR and HLA class I regions, but several studies are demonstrating that anti HLA-DQ antibodies are among the most frequent anti HLA antibodies that develop after transplantation and can have great influence on the developing of humoral rejection and graft loss. In this article we review the gene structure and nomenclature of the HLA-DQ region, the role of anti HLA-DQ antibodies after and before transplantation and briefly the associations of particular HLA-DQ alleles and other diseases...
July 2015: Transplantation Reviews
https://www.readbyqxmd.com/read/25942574/crossreactivity-to-vinculin-and-microbes-provides-a-molecular-basis-for-hla-based-protection-against-rheumatoid-arthritis
#20
Jurgen van Heemst, Diahann T S L Jansen, Savvas Polydorides, Antonis K Moustakas, Marieke Bax, Anouk L Feitsma, Diënne G Bontrop-Elferink, Martine Baarse, Diane van der Woude, Gert-Jan Wolbink, Theo Rispens, Frits Koning, René R P de Vries, George K Papadopoulos, Georgios Archontis, Tom W Huizinga, René E Toes
The HLA locus is the strongest risk factor for anti-citrullinated protein antibody (ACPA)(+) rheumatoid arthritis (RA). Despite considerable efforts in the last 35 years, this association is poorly understood. Here we identify (citrullinated) vinculin, present in the joints of ACPA(+) RA patients, as an autoantigen targeted by ACPA and CD4(+) T cells. These T cells recognize an epitope with the core sequence DERAA, which is also found in many microbes and in protective HLA-DRB1*13 molecules, presented by predisposing HLA-DQ molecules...
2015: Nature Communications
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