keyword
https://read.qxmd.com/read/38485664/the-role-of-anticomplement-therapy-in-the-management-of-the-kidney-allograft
#1
REVIEW
Mehmet Kanbay, Sidar Copur, Zeynep Y Yilmaz, Dilek Ertoy Baydar, Ilmay Bilge, Caner Susal, Burak Kocak, Alberto Ortiz
As the number of patients living with kidney failure grows, the need also grows for kidney transplantation, the gold standard kidney replacement therapy that provides a survival advantage. This may result in an increased rate of transplantation from HLA-mismatched donors that increases the rate of antibody-mediated rejection (AMR), which already is the leading cause of allograft failure. Plasmapheresis, intravenous immunoglobulin therapy, anti-CD20 therapies (i.e., rituximab), bortezomib and splenectomy have been used over the years to treat AMR as well as to prevent AMR in high-risk sensitized kidney transplant recipients...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38476237/poor-prognostic-factors-of-pharmacokinetic-origin-predict-outcomes-in-inflammatory-bowel-disease-patients-treated-with-anti-tumor-necrosis-factor-%C3%AE
#2
JOURNAL ARTICLE
Elizabeth A Spencer, Marla C Dubinsky, Michael A Kamm, Maria Chaparro, Paolo Gionchetti, Fernando Rizzello, Javier P Gisbert, Emily K Wright, Julien D Schulberg, Amy L Hamilton, Dermot P B McGovern, Thierry Dervieux
INTRODUCTION: We evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic factors (PPF) of pharmacokinetic (PK) origin impacting immune response (formation of antidrug antibodies) and disease control of inflammatory bowel disease (IBD) patients treated with infliximab or adalimumab. METHODS: Baseline Clearance was estimated in IBD patients before starting treatment using weight and serum albumin concentrations...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38469118/external-proficiency-testing-for-histocompatibility-and-immunogenetics-in-today-and-future
#3
REVIEW
Fatma Savran Oguz
The Histocompatibility and Immunogenetics laboratories provide disease association and pharmacogenetic analyses as well as the tests required for transplantation immunology and transfusion medicine. They perform Human Leukocyte Antigen (HLA) genotyping in patients/recipients and potential donor candidates for solid organ and stem cell transplants using various molecular methods, and determine mismatches. In addition, they also perform HLA antibody tests to detect anti-HLA antibodies in patients and flow cross-matches to evaluate donor-recipient compatibility...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38464203/hu8f4-car-t-cells-with-mutated-fc-spacer-segment-improve-target-specificity-and-mediate-anti-leukemia-activity-in-vivo
#4
Jeffrey Molldrem, Hong He, Rolando Vedia, Sijie Lu, Qiaochuan Li, Kathryn Cox, Lisa St John, Anna Sergeeva, Karen Clise-Dwyer, Gheath Alatrash, Elizabeth Shpall, Qing Ma
Hu8F4 is a T cell receptor (TCR)-like antibody with high affinity for leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into a chimeric antigen receptor (CAR) format, Hu8F4-CAR is comprised of the Hu8F4 scFv, the human IgG1 CH2CH3 extracellular spacer domain, a human CD28 costimulatory domain, and the human CD3ζ signaling domain. We have demonstrated high efficacy of Hu8F4-CAR-T cells against PR1/HLA-A2-expressing cell lines and leukemic blasts from AML patients in vitro. Previous studies have shown that modification of the Fc domains of IgG4 CH2CH3 spacer regions can eliminate activation-induced cell death and off-target killing mediated by mouse Fc gamma receptor (FcgR)-expressing cells...
February 19, 2024: Research Square
https://read.qxmd.com/read/38462403/exploration-of-potential-immune-mechanisms-in-cervical-dystonia
#5
JOURNAL ARTICLE
Laura M Scorr, Gamze Kilic-Berkmen, Diane J Sutcliffe, Ashok R Dinasarapu, J Lucas McKay, Pritha Bagchi, Michael D Powell, Jeremy M Boss, Nezih Cereb, Marian Little, Loren Gragert, John Hanfelt, Andrew McKeon, William Tyor, H A Jinnah
BACKGROUND: Although there are many possible causes for cervical dystonia (CD), a specific etiology cannot be identified in most cases. Prior studies have suggested a relationship between autoimmune disease and some cases of CD, pointing to possible immunological mechanisms. OBJECTIVE: The goal was to explore the potential role of multiple different immunological mechanisms in CD. METHODS: First, a broad screening test compared neuronal antibodies in controls and CD...
February 17, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38462366/-pathogenetic-analysis-of-transfusion-related-acute-lung-injury-caused-by-human-leukocytes-antigen-antibody-against-human-leukocyte-antigen
#6
JOURNAL ARTICLE
J Deng, X Z Xu, X Ye, Y K Chen, H Q Ding, J Liu, W J Xia, D W Chen, Y R Xu
From September 2019 to October 2020, pathogenetic analysis of three patients clinically diagnosed as transfusion-related acute lung injury (TRALI) caused by human leukocyte antibodies was conducted by Guangzhou Blood Centre, including 2 males and 1 female, aged 56, 50 and 20 years old, respectively. Solid phase agglutination, anti-human globulin test and flow cytometry method were used to detect the presence of antibodies against patients. Sequencing-based human leukocyte antigen (HLA-SBT) typing technique was used to detect the human leukocyte antigen (HLA) genotypes of patients...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462362/-establishing-and-verifying-the-threshold-value-of-hla-mixed-antigen-reagent-screening-test-results
#7
JOURNAL ARTICLE
L Y Chen, X J Bao, X N Yuan, L Y Yu, J He
Objective: To establish the threshold value of human leukocyte antigen (HLA) mixed antigen reagent screening test results, and to verify it by HLA single antigen reagent confirmation test results. Methods: The results of 2 255 serum samples tested for HLA antibodies by HLA mixed antigen reagent in the department of HLA Laboratory, the First Affiliated Hospital of Soochow University from October 2017 to December 2021 were retrospectively analyzed. Among them, 1 139 samples were also tested by single antigen HLA Class-Ⅰ reagent and 1 116 samples were also tested by single antigen HLA Class-Ⅱ reagent...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462360/-effect-of-sirolimus-combined-with-anti-cd20-monoclonal-antibody-desensitization-on-the-prognosis-of-patients-underwent-haploidentical-stem-cell-transplantation
#8
JOURNAL ARTICLE
N Ma, Z D Wang, Y Q Sun, C H Yan, F R Wang, X D Mo, M Lyu, X Y Zhao, X S Zhao, W Han, H Chen, Y Y Chen, Y Wang, L P Xu, Y F Cheng, X H Zhang, K Y Liu, X J Huang, Y J Chang
Objective: To investigate the effects of sirolimus combined with anti-CD20 monoclonal antibody desensitization on the prognosis of patients with haploidentical stem cell transplantation (haplo-SCT). Methods: Fifteen consecutive patients who received haplo-SCT and pre-transplant donor specific anti-human leukocyte antigen (HLA) antibody (DSA) positive [mean fluorescence intensity (MFI)≥2 000] in the Institute of Hematological Diseases from November 2021 to March 2023 were retrospectively recruited into the desensitized group...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38457608/identification-of-early-risk-factors-for-anti-citrullinated-protein-antibody-positive-rheumatoid-arthritis-a-prospective-cohort-study
#9
JOURNAL ARTICLE
Alexandra Cîrciumaru, Yogan Kisten, Monika Hansson, Linda Mathsson-Alm, Vijay Joshua, Heidi Wähämaa, Malena Loberg Haarhaus, Joakim Lindqvist, Leonid Padyukov, Sergiu-Bogdan Catrina, Guozhong Fei, Nancy Vivar, Hamed Rezaei, Erik Af Klint, Aleksandra Antovic, Bence Réthi, Anca I Catrina, Aase Hensvold
OBJECTIVE: Individuals positive for anti-cyclic-peptide-antibodies (anti-CCP) and musculoskeletal complaints (MSK-C) are at risk for developing rheumatoid arthritis (RA). In this study we aimed to investigate factors involved in arthritis progression. METHODS: Anti-CCP2-positive individuals with MSK-C referred to a rheumatologist were recruited. Individuals lacked arthritis at clinical and ultrasound examination and were followed for ≥three years or until clinical arthritis diagnosis...
March 8, 2024: Rheumatology
https://read.qxmd.com/read/38450943/high-resolution-hla-genotyping-identifies-risk-alleles-in-both-class-i-and-ii-for-primary-autoimmune-neutropenia-in-early-childhood-in-a-danish-cohort
#10
JOURNAL ARTICLE
Kirstine Kløve-Mogensen, Thure Mors Haunstrup, Tania Nicole Masmas, Andreas Glenthøj, Petter Höglund, Henrik Hasle, Kaspar René Nielsen, Rudi Steffensen
HLA studies in patients with autoimmune neutropenia (AIN) have shown very consistent results for the association with HLA class II alleles at low resolution. This study aimed to examine the association of both HLA class I and class II at high resolution to clarify the contribution of risk alleles to the disease. A total of 107 AIN patients were genotyped for six loci of HLA class I (HLA-A, -B and -C) and class II (HLA-DRB1, -DQB1, and -DPB1) genes by a high-resolution (3-field, 6-digit) analysis and compared with HLA typing of 1000 healthy controls...
March 2024: HLA
https://read.qxmd.com/read/38449620/coexistence-of-anti-nmdar-and-anti-iglon5-antibodies-in-an-autoimmune-encephalitis-patient-the-first-case-report
#11
Yu Tian, Lu Han, Cameron Lenahan, Tao Wang, Tian Tian, Rui Liu, Lijuan Liu, Jian Huang, Lu Wang, Xiao Hu
BACKGROUND: The coexistence of autoimmune encephalitis (AE) with multiple neural auto-antibodies is of great clinical significance because overlying antibodies may cause superposition or variation of clinical syndrome, which increases the difficulty of diagnosis and treatment of the disease. To the best of our knowledge, the coexistence of anti-N-methyl d-aspartate Receptor (NMDAR) and anti-IgLON5 antibodies in AE has not been published previously. CASE PRESENTATION: A 38-year-old female patient presented to our hospital due to headache and abnormal psychiatric behavior...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38449616/thyroid-dysfunction-td-induced-by-pd-1-pd-l1-inhibitors-in-advanced-lung-cancer
#12
REVIEW
Yanling Wang, Xiaoxuan Yang, Jia Ma, Shenglan Chen, Ping Gong, Ping Dai
BACKGROUND: Thyroid Dysfunction (TD) is a common immune-related adverse events (irAEs) in the treatment of advanced lung cancer with programmed cell death protein 1 (PD-1) and programmed death 1 ligand (PD-L1) inhibitors, with incidence accounting for 6-8% of all irAEs. The incidence of TD is receiving increasing attention from clinicians, given its potential impact on clinical efficacy. However, the molecular mechanisms, biomarkers, and clinical impact of TD resulting from PD-1/PD-L1 inhibitor treatment in advanced lung cancer are unclear...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38443603/anti-tumor-necrosis-factor-atnf-weaning-strategy-in-juvenile-idiopathic-arthritis-jia-does-duration-matter
#13
JOURNAL ARTICLE
Kai Liang Teh, Lena Das, Yun Xin Book, Sook Fun Hoh, Xiaocong Gao, Thaschawee Arkachaisri
BACKGROUND: To compare outcomes of a short and long weaning strategy of anti-tumor necrosis factor (aTNF) in our prospective juvenile idiopathic arthritis (JIA) cohort. RESEARCH DESIGN AND METHODS: JIA patients on subcutaneous adalimumab with at least 6 months of follow-up were recruited (May 2010-Jan 2022). Once clinical remission on medication (CRM) was achieved, adalimumab was weaned according to two protocols-short (every 4-weekly for 6 months and stopped) and long (extending dosing interval by 2 weeks for three cycles until 12-weekly intervals and thereafter stopped) protocols...
March 5, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38436533/antibody-mediated-rejection-amr-in-pediatric-lung-transplantation-current-state-and-future-directions
#14
JOURNAL ARTICLE
Christian Benden, Kathryn A Wikenheiser-Brokamp
Lung transplantation is considered as the ultimate therapy for children with advanced pulmonary disease. International data show a median conditional 1-year post-transplantation survival of 9.1 years. Recently, antibody-mediated rejection (AMR) has increasingly been recognized as an important cause of allograft dysfunction although pediatric reports are still scarce. Donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are known to play a role in AMR development post-transplant but AMR pathogenesis is still poorly understood...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38436133/a-flexible-mouse-model-of-autoimmune-thyroiditis-induced-by-immunization-with-an-adenovirus-containing-full-length-thyroglobulin-cdna
#15
JOURNAL ARTICLE
Aizhan Kozhakhmetova, Yaron Tomer, Mihaela Stefan-Lifshitz
The main challenge in the "post-GWAS" era is to determine the functional meaning of genetic variants and their contribution to disease pathogenesis. Development of suitable mouse models is critical because disease susceptibility is triggered by complex interactions between genetic, epigenetic, and environmental factors that cannot be modeled by in vitro models. Thyroglobulin (TG) is a key gene for autoimmune thyroid disease (AITD) and several single nucleotide polymorphisms (SNPs) in the TG coding region have been associated with AITD...
March 2024: Current protocols
https://read.qxmd.com/read/38433722/strong-humoral-response-after-covid-19-vaccination-correlates-with-the-common-hla-allele-a-03-01-and-protection-from-breakthrough-infection
#16
JOURNAL ARTICLE
Roberto Crocchiolo, Coralie Frassati, Anna Maria Gallina, Pascal Pedini, Sandrine Maioli, Luca Veronese, Arianna Pani, Francesco Scaglione, Federico D'Amico, Lara Crucitti, Nicoletta Sacchi, Silvano Rossini, Christophe Picard
Few data exist on the role of genetic factors involving the HLA system on response to Covid-19 vaccines. Moving from suggestions of a previous study investigating the association of some HLA alleles with humoral response to BNT162b2, we here compared the HLA allele frequencies among weak (n = 111) and strong (n = 123) responders, defined as those healthcare workers with the lowest and the highest anti-Spike antibody levels after vaccination. Individuals with clinical history of Covid-19 or positive anti-nucleocapside antibodies were excluded...
March 2024: HLA
https://read.qxmd.com/read/38425314/hla-dqb1-05-subtypes-and-not-drb1-10-01-mediates-risk-in-anti-iglon5-disease
#17
JOURNAL ARTICLE
Selina M Yogeshwar, Sergio Muñiz-Castrillo, Lidia Sabater, Vicente Peris-Sempere, Vamsee Mallajosyula, Guo Luo, Han Yan, Eric Yu, Jing Zhang, Ling Lin, Flavia Fagundes Bueno, Xuhuai Ji, Géraldine Picard, Véronique Rogemond, Anne Laurie Pinto, Anna Heidbreder, Romana Höftberger, Francesc Graus, Josep Dalmau, Joan Santamaria, Alex Iranzo, Bettina Schreiner, Maria Pia Giannoccaro, Rocco Liguori, Takayoshi Shimohata, Akio Kimura, Yoya Ono, Sophie Binks, Sara Mariotto, Alessandro Dinoto, Michael Bonello, Christian J Hartmann, Nicola Tambasco, Pasquale Nigro, Harald Prüss, Andrew McKeon, Mark M Davis, Sarosh R Irani, Jérôme Honnorat, Carles Gaig, Carsten Finke, Emmanuel Mignot
Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The disease displays a heterogeneous phenotype that includes sleep, movement, and bulbar-associated dysfunction. Presence of IgLON5-antibodies in CSF/serum, together with a strong association with HLA-DRB1*10:01∼DQB1*05:01, support an autoimmune basis. In this study, a multicentric HLA study of 87 anti-IgLON5 patients revealed a stronger association with HLA-DQ than HLA-DR. Specifically, we identified a predisposing rank-wise association with HLA-DQA1*01:05∼DQB1*05:01, HLA-DQA1*01:01∼DQB1*05:01 and HLA-DQA1*01:04∼DQB1*05:03 in 85% of patients...
March 1, 2024: Brain
https://read.qxmd.com/read/38418315/including-the-liver-in-the-visceral-allograft-impact-on-donor-specific-anti-hla-antibodies-and-long-term-outcomes
#18
JOURNAL ARTICLE
Dace Abele, Markus Gäbel, Mihai Oltean, Jonas Varkey, Johan Mölne, Nils Ekwall, Helena Borg, Hanna Jacobsson, Jan Holgersson, Gustaf Herlenius
Humoral immunity emerges as a risk factor for graft failure after visceral transplantation (VTx) and development of donor-specific anti-HLA antibodies (DSAs) has been linked with poor outcomes. In most cases, a simultaneous liver transplant can be safely performed in sensitized patients with DSA and appears protective against lymphocytotoxic antibodies. We investigated the incidence of acute (AR) and chronic rejection (CR) in 32 VTx without any B cell-depleting pre-treatment (6 isolated intestinal transplants (IT) and 26 liver-containing, multivisceral transplants (MVT) and assessed the presence of donor-specific antibodies (DSA) pre- and post-transplantation...
February 27, 2024: Human Immunology
https://read.qxmd.com/read/38414976/enhanced-donor-antigen-presentation-by-b-cells-predicts-acute-cellular-rejection-and-late-outcomes-after-transplantation
#19
JOURNAL ARTICLE
Chethan Ashokkumar, Mylarappa Ningappa, Vikram Raghu, George Mazariegos, Brandon W Higgs, Paul Morgan, Lisa Remaley, Tamara Fazzolare Martin, Pamela Holzer, Kevin Trostle, Qingyong Xu, Adriana Zeevi, James Squires, Kyle Soltys, Simon Horslen, Ajai Khanna, Armando Ganoza, Rakesh Sindhi
BACKGROUND: Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index (API) in an exploratory cohort of liver and intestine transplant (LT and IT) recipients. METHODS: To test clinical performance, we measured the API using the previously described 6-h assay in 84 LT and 54 IT recipients with median age 3...
March 2024: Transplantation Direct
https://read.qxmd.com/read/38412870/expansion-of-hla-dr-peripheral-helper-t-and-na%C3%A3-ve-b-cells-in-anti-citrullinated-protein-antibody-positive-subjects-at-risk-for-rheumatoid-arthritis
#20
JOURNAL ARTICLE
Hideto Takada, M Kristen Demoruelle, Kevin D Deane, Shohei Nakamura, Yasuhiro Katsumata, Katsunori Ikari, Jane H Buckner, William H Robinson, Jennifer A Seifert, Marie L Feser, LauraKay Moss, Jill M Norris, Masayoshi Harigai, Elena W Y Hsieh, V Michael Holers, Yuko Okamoto
OBJECTIVES: To investigate immune dysregulation in the peripheral blood that contributes to the pre-rheumatoid arthritis (RA) stage of RA development in anti-citrullinated protein antibody (ACPA)+ individuals. METHODS: Using 37 markers by mass cytometry, we investigated peripheral blood mononuclear cells (PBMCs) from ACPA+ at-risk individuals (ARI), ACPA+ early untreated RA patients, and ACPA- controls in the Tokyo Women's Medical University (TWMU) cohort (n = 17 in each group)...
February 27, 2024: Arthritis & Rheumatology
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