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Mycobacterium tuberculosis Beijing

Oksana Pasechnik, Anna Vyazovaya, Stanislav Vitriv, Marina Tatarintseva, Aleksey Blokh, Vladimir Stasenko, Igor Mokrousov
This population-based study characterized Mycobacterium tuberculosis isolates from HIV-positive and HIV-negative tuberculosis (TB) patients in the Omsk region in Western Siberia, Russia. We sought to gain insight into the major genotype families and epidemic and endemic clones of M. tuberculosis in the area with a high burden and adverse trend of TB/HIV coinfection. The study collection included M. tuberculosis isolates from 207 newly-diagnosed patients with pulmonary TB; 55 (26.5%) of patients were HIV-infected...
January 2018: Tuberculosis
Hanifeh Erie, Hami Kaboosi, Naeme Javid, Hesamaddin Shirzad-Aski, Masoumeh Taziki, Maya Babaee Kuchaksaraee, Ezzat Allah Ghaemi
Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis . This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated...
December 2017: Iranian Journal of Microbiology
Xiaoqian Zhai, Tao Luo, Xuan Peng, Pengjiao Ma, Chuhan Wang, Chunxi Zhang, Jing Suo, Lang Bao
Genetic variations among genes of Mycobacterium tuberculosis may be associated with antigenic variation and immune evasion, which complicates the pathogenesis of M. tuberculosis. The hyper-virulent M. tuberculosis Beijing strains harbored several large sequence deletions, among which RD207 attributed to the deletion of CRISPR loci and several Cas genes. RD207 also gave rise to a truncated gene Rv2820c-Bj with 60% deletion in length at the 3'-end and a new 3'-end of five amino acid mutations. It has been reported that Rv2820c-Bj correlated with enhanced intracellular survival of M...
January 30, 2018: Infection, Genetics and Evolution
Fengmin Huo, Jingjing Luo, Jin Shi, Zhaojing Zong, Wei Jing, Wenzhu Dong, Lingling Dong, Yifeng Ma, Qian Liang, Yuanyuan Shang, Hairong Huang, Yu Pang
In this report, we conducted bacterial population profile studies to assess trends of rifampicin (RIF) resistance from 2005 to 2015 of Mycobacterium tuberculosis (MTB) isolates collected across China. A total of randomly selected 273 and 269 MTB isolates from 2005 and 2015, respectively, were analyzed. The rates of RIF resistance (36.4%), isoniazid resistance (39.0%), and levofloxacin resistance (25.7%) in 2015 were significantly higher than in 2005 (28.2%, 30.0%, and 15.4%, respectively; P < 0.05). Genotypic data revealed 256 (95...
January 29, 2018: Antimicrobial Agents and Chemotherapy
Louis S Ates, Anzaan Dippenaar, Roy Ummels, Sander R Piersma, Aniek D van der Woude, Kim van der Kuij, Fabien Le Chevalier, Dulce Mata-Espinosa, Jorge Barrios-Payán, Brenda Marquina-Castillo, Carolina Guapillo, Connie R Jiménez, Arnab Pain, Edith N G Houben, Robin M Warren, Roland Brosch, Rogelio Hernández-Pando, Wilbert Bitter
Mycobacterium tuberculosis requires a large number of secreted and exported proteins for its virulence, immune modulation and nutrient uptake. Most of these proteins are transported by the different type VII secretion systems1,2. The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus3,4. However, the role of these proteins remains largely elusive 1 ...
January 15, 2018: Nature Microbiology
L Y Chen, X Yang, H H Ru, H J Yang, S Q Yan, L Ma, J O Chen, R Yang, L Xu
Objective: To understand the characteristics of genotypes of Mycobacterium tuberculosis isolates in Yunnan province, and provide the molecular epidemiological evidence for prevention and control of tuberculosis in Yunnan Province. Methods: Mycobacterium Tuberculosis isolates were collected from 6 prefectures of Yunnan province in 2014 and their Genetypes of Mycobacterium tuberculosis isolates were obtained using spoligotyping and multiple locus variable numbers of tandem repeats analysis (MLVA). The results of spoligotyping were entered into the SITVITWEB database to obtain the Spoligotyping International Type (SIT) patterns and the sublineages of MTB isolates...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Arnold Bainomugisa, Evelyn Lavu, Stenard Hiashiri, Suman Majumdar, Alice Honjepari, Rendi Moke, Paison Dakulala, Grant A Hill-Cawthorne, Sushil Pandey, Ben J Marais, Chris Coulter, Lachlan Coin
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 of 165 clinical isolates referred from Daru General Hospital to the Supranational reference laboratory, Brisbane, during 2012-2015 revealed that 95 belonged to a single modern Beijing sub-lineage strain. Molecular dating suggested acquisition of streptomycin and isoniazid resistance in the 1960s, with potentially enhanced virulence mediated by an mycP1 mutation...
January 4, 2018: Microbial Genomics
P W Ei, W W Aung, W W Nyunt, T L Swe, M M Htwe, S M Win, S T Aung, C L Chang, H-Y Lee, J S Lee
SETTING: Two tuberculosis (TB) reference laboratories in Myanmar. OBJECTIVES: To determine the proportion of extensively drug-resistant TB (XDR-TB) cases among multidrug-resistant TB (MDR-TB) cases and the mutations that cause resistance to second-line drugs in Myanmar. DESIGN: This was a cross-sectional, retrospective study. Multidrug-resistant Mycobacterium tuberculosis isolates were collected during 2015-2016. Phenotypic drug susceptibility testing (DST) was performed and drug-resistant mutations identified by sequencing...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan
Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M. tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China...
December 29, 2017: Frontiers of Medicine
Yaoju Tan, Biyi Su, Huiwen Zheng, Yuanyuan Song, Yufeng Wang, Yu Pang
Prothionamide (PTH) has been widely used in the treatment of tuberculosis (TB), especially multidrug resistant tuberculosis (MDR-TB), while data regarding prevalence of resistance-causing mutation is limited. In this study, we aimed to investigate the molecular characteristics of PTH-resistant MTB isolates, and also analyzed the risk factors for PTH resistance among Mycobacterium tuberculosis (MTB) isolates in southern China. A total of 282 MTB isolates were enrolled in from Guangzhou Chest Hospital. Among these isolates, 46 (16...
2017: Frontiers in Microbiology
N T C Maguga-Phasha, N S Munyai, F Mashinya, M E Makgatho, E F Mbajiorgu
BACKGROUND: Tuberculosis remains a major health problem and knowledge of the diversity of Mycobacterium tuberculosis strains in specific geographical regions can contribute to the control of the disease. This study describes the genetic profile of M. tuberculosis in five districts of Limpopo Province. METHODS: A total 487 isolates were collected from the National Health Laboratory Services from all regions/districts of Limpopo Province. Only 215 isolates were confirmed to be M...
December 12, 2017: BMC Infectious Diseases
Oksana Pasechnik, Maya Alexandrovna Dymova, Vladimir Leonidovich Stasenko, Aleksey Igorevich Blokh, Marina Petrovna Tatarintseva, Lyubov Pavlovna Kolesnikova, Maksim Leonidovich Filipenko
BACKGROUND & OBJECTIVES: A complicated epidemiological situation characterized by significantly high tuberculosis (TB) morbidity is observed in West Siberia. This study was aimed to investigate the genetic characteristics of Mycobacterium tuberculosis circulating in the southern part of West Siberia (in the Omsk region). METHODS: From March 2013 to January 2015, 100 isolates of M. tuberculosis were obtained from patients with pulmonary TB living in the Omsk region...
July 2017: Indian Journal of Medical Research
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz, İsabel Raika Durusoy Onmuş, Tuğba Bozdemir, Hüseyin Taşlı, Mine Hoşgör Limoncu
Background/aim: The Aegean Region is the second-ranking region in Turkey according to the Human Development Index and population density and it hosts 1/8 of Turkey's population. İzmir is the largest city of the region, receiving internal migration both from inside and outside the region. The tuberculosis incidence in İzmir is lower than overall in Turkey: 17.7/100,000 in 2011. Our aims were to determine genotypes of Mycobacterium tuberculosis isolates; to explore possible associations between genotypes with case-demographic data, clinical presentation, and antimicrobial susceptibility patterns; and to determine variations in genotype distribution of strains isolated in Ege University Hospital, İzmir...
November 13, 2017: Turkish Journal of Medical Sciences
Igor Mokrousov, Ekaterina Chernyaeva, Anna Vyazovaya, Yuriy Skiba, Natalia Solovieva, Violeta Valcheva, Klavdia Levina, Natalya Malakhova, Wei-Wei Jiao, Lia Lima Gomes, Philip N Suffys, Marge Kütt, Nagima Aitkhozhina, A-Dong Shen, Olga Narvskaya, Viacheslav Zhuravlev
Mycobacterium tuberculosis isolates of the Beijing 94-32-cluster (also named "Central Asian/Russian Beijing strain") constitute an important component of the population structure of the pathogen in the Former Soviet Union (FSU) countries (1-4).….
November 15, 2017: Journal of Clinical Microbiology
Yi Liu, Xiaoying Jiang, Wensheng Li, Xuxia Zhang, Wei Wang, Chuanyou Li
The predominant prevalent Mycobacterium tuberculosis (M. tb) lineage was the Beijing genotype family in Beijing. There has been no systematic study on the association between drug resistance and Beijing genotype. Here we collected 268 M. tb strains, analyzed the background information and the bacteriological characteristics. The mean age of the cases was 40.12 years; male patients were almost three times than female patients. After genotyping analyzation, 81.7% (219/268) strains were categorized as Beijing genotype; no significant difference was observed between Beijing and non-Beijing genotype in gender, age and treatment history...
November 8, 2017: Scientific Reports
Anna Vyazovaya, Klavdia Levina, Viacheslav Zhuravlev, Piret Viiklepp, Marge Kütt, Igor Mokrousov
Objectives: We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circulating genotypes. Estonia received a mass immigration from Russia during 1945-90 followed by enhanced interaction with the EU since 1991. Methods: The study sample included M. tuberculosis isolates from patients newly diagnosed with TB in 2014 in North Estonia (including the capital Tallinn)...
October 30, 2017: Journal of Antimicrobial Chemotherapy
Charlotte Genestet, Florence Ader, Catherine Pichat, Gérard Lina, Oana Dumitrescu, Sylvain Goutelle
While isoniazid and rifampicin have been the cornerstone of tuberculosis therapy caused by drug-susceptible Mycobacterium tuberculosis for more than 40 years, their combined action has never been thoroughly assessed by modern quantitative pharmacology approaches.The aims of this work were to perform in vitro experiments and mathematical modeling of the antibacterial effect of isoniazid and rifampicin alone and in combination against various strains of Mycobacterium tuberculosisAfter MIC determination of H37Rv and three strains belonging to the, Beijing, Euro-American and Indo-Oceanic lineages, the antibacterial effects of isoniazid and rifampicin alone and in combination were studied in static time-kill experiments...
October 23, 2017: Antimicrobial Agents and Chemotherapy
Sven Hoffner, Leyla Sahebi, Khalil Ansarin, Siamak Sabour, Parviz Mohajeri
OBJECTIVE: The Beijing genotype is a distinct genetic lineage of Mycobacterium tuberculosis, which is distributed worldwide, and may cause large outbreaks of multidrug resistance-tuberculosis (MDR-TB). The distribution of such strains in the Eastern Mediterranean region (EMR) is unclear, and clarifying the data is our purpose apart from the presence of Beijing TB in Iran. METHODS: We searched Published literature from CINAHL Cochrane Library, Current Contents, Database of Abstracts of Reviews of Effects (DARE), ProQuest Google Scholar PubMed, PsycINFO, Thomson Reuters, (SID), and Medical Library (MedLib) to detect relevant studies from the year 2000 to July 2015 with the following keywords: M...
October 23, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Samira Tarashi, Abolfazl Fateh, Fatemeh Rahimi Jamnani, Seyed Davar Siadat, Farzam Vaziri
Antimicrobial drug resistance creates major problems in the control of tuberculosis (TB). Beijing and Haarlem genotypes of Mycobacterium tuberculosis are the prevalent genotypes responsible for multidrug resistant (MDR) TB worldwide. The aim of this study was to conduct a systematic review using meta-analysis to indicate the prevalence of Beijing and Haarlem genotypes among MDR-TB cases in Iran. Data sources of current study were 311 original articles (2006-2016) that were searched in several databases including Medline, Scopus, Embase, Cochrane library, and Iranian databases...
December 2017: Tuberculosis
Yoshiro Murase, Kiyohiko Izumi, Akihiro Ohkado, Akio Aono, Kinuyo Chikamatsu, Hiroyuki Yamada, Yuriko Igarashi, Akiko Takaki, Satoshi Mitarai
Strain genotyping based on the variable-number tandem repeat (VNTR) is widely applied for identifying the transmission of Mycobacterium tuberculosis A consensus set of four hypervariable loci (1982, 3232, 3820, and 4120) has been proposed to improve the discrimination of Beijing lineage strains. Herein, we evaluated the utility of these four hypervariable loci for tracing local tuberculosis transmission in 981 cases over a 14-month period in Japan (2010--2011). We used six different VNTR systems, with or without the four hypervariable loci...
October 18, 2017: Journal of Clinical Microbiology
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