keyword
https://read.qxmd.com/read/38518003/multidrug-resistant-mycobacterium-tuberculosis-transmission-in-shandong-china
#1
JOURNAL ARTICLE
Yingying Li, Yifan Li, Tingting Wang, Yameng Li, Ningning Tao, Xianglong Kong, Yuzhen Zhang, Qilin Han, Yao Liu, Huaichen Li
Multidrug-resistant tuberculosis (MDR-TB) has imposed a significant economic and health burden worldwide, notably in China. Using whole genome sequence, we sought to understand the mutation and transmission of MDR-TB in Shandong. A retrospective study of patients diagnosed with pulmonary tuberculosis in Shandong from 2009 to 2018 was conducted. To explore transmission patterns, we performed whole genome sequencing on MDR-TB isolates, identified genomic clusters, and assessed the drug resistance of TB isolates...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38510248/antigen-specific-chemokine-profiles-as-biomarkers-for-detecting-mycobacterium-tuberculosis-infection
#2
JOURNAL ARTICLE
Weicong Ren, Zichun Ma, Qiang Li, Rongmei Liu, Liping Ma, Cong Yao, Yuanyuan Shang, Xuxia Zhang, Mengqiu Gao, Shanshan Li, Yu Pang
BACKGROUND: Latent tuberculosis (TB) infection can progress to active TB, which perpetuates community transmission that undermines global TB control efforts. Clinically, interferon-γ release assays (IGRAs) are commonly used for active TB case detection. However, low IGRA sensitivity rates lead to false-negative results for a high proportion of active TB cases, thus highlighting IGRA ineffectiveness in differentiating MTB-infected individuals from healthy individuals. METHODS: Participants enrolled at Beijing Chest Hospital from May 2020-April 2022 were assigned to healthy control (HC), LTBI, IGRA-positive TB, and IGRA-negative TB groups...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38482360/genetic-diversities-of-mycobacterium-tuberculosis-complex-species-in-western-kenya
#3
JOURNAL ARTICLE
Charles Komen Chelimo, Paul Oyieng Angienda, Charles Ochieng Olwal, Henry Nyamogoba
BACKGROUND: Tuberculosis (TB) remains a high-burden infectious disease worldwide. Mycobacterium tuberculosis complex (MTBC) is the aetiological agent of TB. RESEARCH GAP: The TB burden is significantly linked to the development of drug-resistant strains. Thus, there is an urgent need for close surveillance of MTBC circulating in a given region, such as Western Kenya, for treatment of TB. AIM: To determine the proportion of MTBC species, strains and genetic diversities in circulation in HIV/AIDS-prevalent regions, and Western Kenya in particular...
2024: Access microbiology
https://read.qxmd.com/read/38469390/-mycobacterium-tuberculosis-lineage-distribution-using-whole-genome-sequencing-and-bedaquiline-clofazimine-and-linezolid-phenotypic-profiles-among-rifampicin-resistant-isolates-from-west-java-indonesia
#4
JOURNAL ARTICLE
Andriansjah Rukmana, Cynthia Gozali, Linda Erlina
Tuberculosis (TB) is caused by Mycobacterium tuberculosis infection. Indonesia is ranked second in the world for TB cases. New anti-TB drugs from groups A and B, such as bedaquiline, clofazimine, and linezolid, have been shown to be effective in curing drug resistance in TB patients, and Indonesia is already using these drugs to treat patients. However, studies comparing the TB strain types with anti-TB resistance profiles are still relevant to understanding the prevalent strains in the country and their phenotypic characteristics...
2024: International Journal of Microbiology
https://read.qxmd.com/read/38384875/a-first-insight-into-tuberculosis-transmission-at-the-border-of-ecuador-and-colombia-a-retrospective-study-of-the-population-structure-of-mycobacterium-tuberculosis-in-esmeraldas-province
#5
JOURNAL ARTICLE
Bernardo Castro-Rodriguez, Sebastián Espinoza-Andrade, Greta Franco-Sotomayor, José Manuel Benítez-Medina, Natalia Jiménez-Pizarro, Camilo Cárdenas-Franco, Juan Carlos Granda, Jose Luis Jouvin, Solon Alberto Orlando, Javier Hermoso de Mendoza, Miguel Ángel García-Bereguiain
OBJECTIVE: Tuberculosis (TB) is a major public health concern in Ecuador and Colombia, considering that both countries are high-burden TB settings. Molecular epidemiology is crucial to understand the transmission dynamics of Mycobacterium tuberculosis complex (MTBC) and to identify active transmission clusters of regional importance. METHODS: We studied the potential transmission of TB between Colombia and Ecuador through the analysis of the population structure of MTBC lineages circulating in the Ecuadorian province of Esmeraldas at the border with Colombia...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38384306/transmission-dynamics-of-drug-resistant-tuberculosis-in-ningbo-china-an-epidemiological-and-genomic-analysis
#6
JOURNAL ARTICLE
Yang Che, Xiangchen Li, Tong Chen, Yewei Lu, Guoxin Sang, Junli Gao, Junshun Gao, Zhengwei Liu, Tianfeng He, Yi Chen
BACKGROUND: Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a significant public health concern in Ningbo, China. Understanding its molecular epidemiology and spatial distribution is paramount for effective control. METHODS: From December 24, 2020, to March 12, 2023, we collected clinical Mycobacterium tuberculosis (MTB) strains in Ningbo, with whole-genome sequencing performed on 130 MTB strains. We analyzed DR-related gene mutations, conducted phylogenetic and phylodynamic analyses, identified recent transmission clusters, and assessed spatial distribution...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38370790/mathematical-modeling-suggests-heterogeneous-replication-of-mycobacterium-tuberculosis-in-rabbits
#7
Vitaly V Ganusov, Afsal Kolloli, Selvakumar Subbian
Tuberculosis ( TB ), the disease caused by Mycobacterium tuberculosis ( Mtb ), remains a major health problem with 10.6 million cases of the disease and 1.6 million deaths in 2021. It is well understood that pulmonary TB is due to replication of Mtb in the lung but quantitative details of Mtb replication and death in lungs of patients and how these rates are related to the degree of lung pathology are unknown. We performed experiments with rabbits infected with a novel, virulent clinical Mtb isolate of the Beijing lineage, HN878, carrying an unstable plasmid pBP10...
February 7, 2024: bioRxiv
https://read.qxmd.com/read/38368223/immunogenicity-and-protective-efficacy-of-ripa-a-peptidoglycan-hydrolase-against-mycobacterium-tuberculosis-beijing-outbreak-strains
#8
JOURNAL ARTICLE
Kee Woong Kwon, Han-Gyu Choi, Hong-Hee Choi, Eunsol Choi, Hagyu Kim, Hwa-Jung Kim, Sung Jae Shin
Given that individuals with latent tuberculosis (TB) infection represent the major reservoir of TB infection, latency-associated antigens may be promising options for development of improved multi-antigenic TB subunit vaccine. Thus, we selected RipA, a peptidoglycan hydrolase required for efficient cell division of Mycobacterium tuberculosis (Mtb), as vaccine candidate. We found that RipA elicited activation of dendritic cells (DCs) by induction of phenotypic maturation, increased production of inflammatory cytokines, and prompt stimulation of MAPK and NF-κB signaling pathways...
February 16, 2024: Vaccine
https://read.qxmd.com/read/38310744/population-structure-of-mycobacterium-tuberculosis-in-el-oro-a-first-insight-into-ecuador-peru-tuberculosis-transmission
#9
JOURNAL ARTICLE
Bernardo Castro-Rodriguez, Kerly León-Ordóñez, Greta Franco-Sotomayor, José Manuel Benítez-Medina, Natalia Jiménez-Pizarro, Greta Cárdenas-Franco, Juan Carlos Granda, Juan Luis Aguirre-Martínez, Solon Alberto Orlando, Javier Hermoso de Mendoza, Miguel Ángel García-Bereguiain
BACKGROUND: Tuberculosis (TB) is a major public health concern in Ecuador and Peru, both settings of high burden of drug resistance TB. Molecular epidemiology tools are important to understand the transmission dynamics of Mycobacterium tuberculosis Complex (MTBC) and to track active transmission clusters of regional importance. This study is the first to address the transmission of TB between Peru and Ecuador through the population structure of MTBC lineages circulating in the Ecuadorian border province of "El Oro"...
January 29, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38295613/the-occurrence-rate-of-haarlem-and-beijing-genotypes-among-middle-eastern-isolates-of-multi-drug-resistant-mycobacterium-tuberculosis-a-systematic-review-and-meta-analysis
#10
REVIEW
Kianoosh Ferdosnejad, Mohammad Sholeh, Rouhollah Abdolhamidi, Erfan Soroush, Seyed Davar Siadat, Samira Tarashi
Antibiotic resistance is a serious problem that poses a major challenge to tuberculosis control worldwide. Many developing countries still struggle with this infection in term of various aspects as it remains a major health concern. A number of developing countries are located in the Middle East, one of the world's most important regions. The control of this infection remains largely suboptimal despite intensive research in the field, and the mechanisms that lead to its progression have not yet been fully understood...
January 30, 2024: Respiratory Investigation
https://read.qxmd.com/read/38289066/molecular-determinants-of-multidrug-resistant-tuberculosis-in-sierra-leone
#11
JOURNAL ARTICLE
Harriet N A Blankson, Rashidatu Fouad Kamara, Ivan Barilar, Sönke Andres, Ousman S Conteh, Tobias Dallenga, Lynda Foray, Florian Maurer, Katharina Kranzer, Christian Utpatel, Stefan Niemann
Multidrug-resistant tuberculosis (MDR-TB) management has become a serious global health challenge. Understanding its epidemic determinants on the regional level is crucial for developing effective control measures. We used whole genome sequencing data of 238 of Mycobacterium tuberculosis complex (MTBC) strains to determine drug resistance profiles, phylogeny, and transmission dynamics of MDR/rifampicin-resistant (RR) MTBC strains from Sierra Leone. Forty-two strains were classified as RR, 196 as MDR, 5 were resistant to bedaquiline (BDQ) and clofazimine (CFZ), but none was found to be resistant to fluoroquinolones...
January 30, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38252727/molecular-epidemiology-and-drug-resistance-of-mycobacterium-tuberculosis-in-a-tertiary-care-hospital-in-northeastern-mexico
#12
JOURNAL ARTICLE
Amador Flores-Aréchiga, José Luis Zacarías-Hernández, Cecilia Gabriela Vázquez-Cortés, Reyes S Tamez-Guerra, Manuel De la O-Cavazos, Lydia Guadalupe Rivera-Morales, Jorge Martín Llaca-Díaz, Jorge Castro-Garza, Néstor Casillas-Vega, José Manuel Vázquez-Guillén, Cristina Rodríguez-Padilla
INTRODUCTION: Tuberculosis (TB) is a re-emerging disease considered a public health concern. In the present study, we analyzed the epidemiology and drug resistance of Mycobacterium tuberculosis strains isolated from patients with pulmonary TB. METHODOLOGY: Mycobacterium tuberculosis isolates (n = 190) were obtained from patients with pulmonary TB admitted to Dr. José Eleuterio González University Hospital (UH). Each M. tuberculosis isolate was analyzed by spoligotyping (spacer oligonucleotide typing) and MIRU-VNTR (Mycobacterial Interspersed Repetitive Units-Variable Number Tandem Repeat)...
December 31, 2023: Journal of Infection in Developing Countries
https://read.qxmd.com/read/38126135/genomic-analysis-of-lineage-specific-transmission-of-multidrug-resistance-tuberculosis-in-china
#13
JOURNAL ARTICLE
Yi-Fan Li, Xiang-Long Kong, Wan-Mei Song, Ya-Meng Li, Ying-Ying Li, Wei-Wei Fang, Jie-Yu Yang, Chun-Bao Yu, Huai-Chen Li, Yao Liu
OBJECTIVES: We investigated the genetic diversities and lineage specific transmission dynamics of multidrug-resistant tuberculosis (MDR-TB), with the goal of determining the potential factors driving the MDR epidemics in China. METHODS: We curated a large nationwide Mycobacterium tuberculosis (M. tuberculosis) whole genome sequence (WGS) data set, including 1313 MDR strains. We reconstructed the phylogeny and mapped the transmission networks of MDR-TB across China using Bayesian inference...
December 21, 2023: Emerging Microbes & Infections
https://read.qxmd.com/read/38125463/genetic-diversity-of-mycobacterium-tuberculosis-isolates-from-the-central-eastern-and-southeastern-ethiopia
#14
JOURNAL ARTICLE
Mulualem Agonafir, Gurja Belay, Nontuthuko E Maningi, Adey Feleke, Melese Abate Reta, Sharon L Olifant, Mohammed Suaudi Hassen, Tewodros Girma, P Bernard Fourie
INTRODUCTION: The population structure of Mycobacterium tuberculosis complex (MTBC) in Ethiopia is diverse but dominated by Euro-American (Lineage 4) and East-African-Indian (Lineage 3) lineages. The objective of this study was to describe the genetic diversity of MTBC isolates in Central, Eastern and Southeastern Ethiopia. METHODS: A total of 223 MTBC culture isolates obtained from patients referred to Adama and Harar TB reference laboratories were spoligotyped...
December 2023: Heliyon
https://read.qxmd.com/read/38071287/strain-structure-analysis-of-mycobacterium-tuberculosis-circulating-among-hiv-negative-positive-and-drug-resistant-tb-patients-attending-chest-clinics-in-western-kenya
#15
JOURNAL ARTICLE
Martin O Ogwang, Lameck Diero, Florence Ng'ong'a, Gabriel Magoma, Lucy Mutharia, Mabel Imbuga, Caroline Ngugi
BACKGROUND: Despite global tuberculosis (TB) interventions, the disease remains one of the major public health concerns. Kenya is ranked 15th among 22 high burden TB countries globally. METHODS: A cross-sectional study was conducted in Western Kenya, which comprises 10 counties. A multistage sampling method was used where a single sub-county was randomly selected followed by sampling two high volume health facility from each sub-county. Identification of spoligotype profiles and their family distribution and lineage level were achieved by comparison with SITVIT database...
December 9, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/38055064/insidious-transmission-of-mycobacterium-tuberculosis-in-ordos-china-a-molecular-epidemiology-study
#16
JOURNAL ARTICLE
Hailin Sun, Zichun Ma, Fuli Ai, Bing Han, Peng Li, Juan Liu, Yiheng Wu, Yufeng Wang, Bing Li, Dan Qi, Yu Pang
BACKGROUND: In this study, we conducted this population-based study to evaluate the genetic diversity and clustering rate of Mycobacterium tuberculosis (MTB) strains using the whole-genome sequencing (WGS), to better understand its transmission in Ordos. METHODS: All patients with culture-positive TB notified in Ordos from January 2021 to December 2022 were recruited. WGS was performed to analyze single-nucleotide polymorphism (SNP) and to identify genotypic drug susceptibilities of MTB isolates...
December 6, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38048026/tuberculosis-in-ukrainian-war-refugees-and-migrants-in-the-czech-republic-and-slovakia-a-molecular-epidemiological-study
#17
JOURNAL ARTICLE
Matúš Dohál, Věra Dvořáková, Miluše Šperková, Martina Pinková, Arash Ghodousi, Maryam Omrani, Igor Porvazník, Erik Michael Rasmussen, Mária Škereňová, Michaela Krivošová, Jiří Wallenfels, Olha Konstantynovska, Timothy M Walker, Vladyslav Nikolayevskyy, Daniela Maria Cirillo, Ivan Solovič, Juraj Mokrý
BACKGROUND: The war in Ukraine has led to significant migration to neighboring countries, raising public health concerns. Notable tuberculosis (TB) incidence rates in Ukraine emphasize the immediate requirement to prioritize approaches that interrupt the spread and prevent new infections. METHODS: We conducted a prospective genomic surveillance study to assess migration's impact on TB epidemiology in the Czech Republic and Slovakia. Mycobacterium tuberculosis isolates from Ukrainian war refugees and migrants, collected from September 2021 to December 2022 were analyzed alongside 1574 isolates obtained from Ukraine, the Czech Republic, and Slovakia...
December 4, 2023: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38012918/bioarchaeological-and-molecular-evidence-of-tuberculosis-in-human-skeletal-remains-from-18th-19th-century-orthodox-cemeteries-in-irkutsk-eastern-siberia
#18
REVIEW
Natalia Kharlamova, Oleg Ogarkov, Ivan Berdnikov, Natalia Berdnikova, Ravil Galeev, Igor Mokrousov
In this study, we tested the skeletal human remains from the 18th - early 19th century Orthodox cemeteries in Irkutsk, Eastern Siberia, for tuberculosis-associated morphological alterations and Mycobacterium tuberculosis DNA. The morphologically studied bone collection included 591 individuals of mainly Caucasian origin. The molecular methods (IS6110-PCR and spoligotyping) suggested that at least four individuals (out of 15 TB-suspected, DNA-tested) were positive for the presence of M. tuberculosis DNA...
December 2023: Tuberculosis
https://read.qxmd.com/read/38001453/determining-the-risk-factors-for-molecular-clustering-of-drug-resistant-tuberculosis-in-south-africa
#19
JOURNAL ARTICLE
Halima Said, Elizabeth Kachingwe, Yasmin Gardee, Zaheda Bhyat, John Ratabane, Linda Erasmus, Tiisetso Lebaka, Minty van der Meulen, Thabisile Gwala, Shaheed Omar, Farzana Ismail, Nazir Ismail
BACKGROUND: Drug-resistant tuberculosis (DR-TB) epidemic is driven mainly by the effect of ongoing transmission. In high-burden settings such as South Africa (SA), considerable demographic and geographic heterogeneity in DR-TB transmission exists. Thus, a better understanding of risk-factors for clustering can help to prioritise resources to specifically targeted high-risk groups as well as areas that contribute disproportionately to transmission. METHODS: The study analyzed potential risk-factors for recent transmission in SA, using data collected from a sentinel molecular surveillance of DR-TB, by comparing demographic, clinical and epidemiologic characteristics with clustering and cluster sizes...
November 24, 2023: BMC Public Health
https://read.qxmd.com/read/37971428/evolution-and-transmission-of-antibiotic-resistance-is-driven-by-beijing-lineage-mycobacterium-tuberculosis-in-vietnam
#20
JOURNAL ARTICLE
Matthew Silcocks, Xuling Chang, Nguyen Thuy Thuong Thuong, Youwen Qin, Dang Thi Minh Ha, Phan Vuong Khac Thai, Srinivasan Vijay, Do Dang Anh Thu, Vu Thi Ngoc Ha, Hoang Ngoc Nhung, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, David Edwards, Artika Nath, Kym Pham, Nguyen Duc Bang, Tran Thi Hong Chau, Guy Thwaites, A Dorothee Heemskerk, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Rick Twee-Hee Ong, Maxine Caws, Kathryn E Holt, Sarah J Dunstan
Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that Mtb genetic lineage plays in determining the likelihood of resistance evolution. This study offers insight into these questions by assessing the dynamics of resistance evolution in a high-burden Southeast Asian setting with a diverse lineage composition...
November 16, 2023: Microbiology Spectrum
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