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Mycobacterium tuberculosis Beijing

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https://www.readbyqxmd.com/read/29763750/genome-sequence-and-analysis-of-mycobacterium-tuberculosis-strain-swlpk
#1
Muhammad Ibrahim, Asma Muhammad Yar, Ghunva Zaman, Changhui Yan, Muhammad Khurshid, Habib Bokhari
OBJECTIVES: Multidrug resistant Mycobacterium tuberculosis poses a global threat, particularly in developing countries such as Pakistan. Genome sequencing, comparative genomic analysis, and drug resistance gene analysis, could be beneficial for understanding and monitoring M. tuberculosis disease severity in Pakistan by elucidating the biology of M. tuberculosis. METHODS: In this study, we sequenced, assembled, and annotated a draft genome of M. tuberculosis strain swlpk using the Illumina MiSeq 300PE throughput 2M system...
May 12, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29742052/clinical-and-drug-resistance-characteristics-of-new-pediatric-tuberculosis-cases-in-northern-china
#2
Ting Wang, Fang Dong, Qin-Jing Li, Qing-Qin Yin, Wen-Qi Song, Igor Mokrousov, Wei-Wei Jiao, A-Dong Shen
AIM: The aim of this study was to evaluate the clinical features and characteristics of drug resistance in newly diagnosed pediatric tuberculosis (TB) patients in northern China. METHODS: Mycobacterium tuberculosis isolates were collected from September 2010 to October 2016 at the Beijing Children's Hospital. Patients were divided into two groups (resistant to at least one drug and pan-susceptible) according to drug susceptibility testing (DST) results. RESULTS: A total of 132 new cases, mainly from northern China (87...
May 9, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29685006/spoligotyping-analysis-of-mycobacterium-tuberculosis-with-tb-sprint-technology
#3
S Ali, C Sola, M Harrison, M Tahir, A Sheed Khan, M Mumtaz, E Chimara, F Hassan
Spoligotyping is a highly reproducible, fast polymerase chain reaction (PCR)-based approach for identification of different strains of Mycobacterium tuberculosis through genotyping of Mycobacterium tuberculosis complex (MTB). Molecular typing of MTB is helpful for understanding and controlling TB epidemics. Spoligotyping was performed on 166 strains of MTB collected from 25 districts of Khyber Pakhtunkhwa, Pakistan. Results were analyzed using online database, SITVIT2, developed by the Institute Pasteur de Guadeloupe, France and SPSS software V...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29619443/cloning-and-expression-of-mce1a-gene-from-mycobacterium-tuberculosis-beijing-and-h37rv-strain-for-vaccine-candidate-development
#4
Desi Indriarini, Andriansjah Rukmana, Andi Yasmon
Background: Tuberculosis remains the leading cause of death in the world, especially wherever poverty, malnutrition and poor housing prevail. Mycobacterium tuberculosis Beijing strain is the most common strain that causes tuberculosis in Indonesia. The wide spread of tuberculosis has been further aggravated by HIV-AIDS and drug resistance. Unfortunately, Bacille Calmette-Guerin (BCG) as the current vaccine has different protection function and efficacy. According to function analysis, mce1A gene was predicted to have a role in host invasion and survival of Mycobacterium tuberculosis in human macrophages...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29587640/spoligotyping-based-genetic-diversity-of-mycobacterium-tuberculosis-in-ethiopia-a-systematic-review
#5
Begna Tulu, Gobena Ameni
BACKGROUND: Understanding the types of strains and lineages of Mycobacterium tuberculosis (M. tuberculosis) circulating in a country is of paramount importance for tuberculosis (TB) control program of that country. The main aim of this study was to review and compile the results of studies conducted on strains and lineages of M. tuberculosis in Ethiopia. METHODS: A systematic search and review of articles published on M. tuberculosis strains and lineages in Ethiopia were made...
March 27, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29563202/next-generation-sequencing-for-characterizing-drug-resistant-mycobacterium-tuberculosis-genes-from-clinical-isolates-in-the-ukraine
#6
L T Daum, O S Konstantynovska, O S Solodiankin, O O Liashenko, P I Poteiko, V I Bolotin, I I Hrek, A V Rohozhyn, J D Rodriguez, G W Fischer, J P Chambers, A P Gerilovych
The Ukraine ranks among the top twenty countries with the highest number of multi-drug resistant (MDR), and extensively drug resistant (XDR) Mycobacterium tuberculosis (MTB) cases in the world. However, little is known of the genetic diversity, i.e., resistance signatures in clinical isolates from this region. We analyzed seven of most prevalent MDR/XDR antibiotic resistance conferring genes from clinical isolates ( N = 75 ) collected from geographically diverse Ukrainian oblasts and its southern Crimean peninsula...
March 21, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29523319/major-genotype-families-and-epidemic-clones-of-mycobacterium-tuberculosis-in-omsk-region-western-siberia-russia-marked-by-a-high-burden-of-tuberculosis-hiv-coinfection
#7
Oksana Pasechnik, Anna Vyazovaya, Stanislav Vitriv, Marina Tatarintseva, Aleksey Blokh, Vladimir Stasenko, Igor Mokrousov
This population-based study characterized Mycobacterium tuberculosis isolates from HIV-positive and HIV-negative tuberculosis (TB) patients in the Omsk region in Western Siberia, Russia. We sought to gain insight into the major genotype families and epidemic and endemic clones of M. tuberculosis in the area with a high burden and adverse trend of TB/HIV coinfection. The study collection included M. tuberculosis isolates from 207 newly-diagnosed patients with pulmonary TB; 55 (26.5%) of patients were HIV-infected...
January 2018: Tuberculosis
https://www.readbyqxmd.com/read/29487728/the-high-prevalence-of-mycobacterium-tuberculosis-beijing-strain-at-an-early-age-and-extra-pulmonary-tuberculosis-cases
#8
Hanifeh Erie, Hami Kaboosi, Naeme Javid, Hesamaddin Shirzad-Aski, Masoumeh Taziki, Maya Babaee Kuchaksaraee, Ezzat Allah Ghaemi
Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis . This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated...
December 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29407192/the-truncated-rv2820c-of-mycobacterium-tuberculosis-beijing-family-augments-intracellular-survival-of-m-smegmatis-by-altering-cytokine-profile-and-inhibiting-no-generation
#9
Xiaoqian Zhai, Tao Luo, Xuan Peng, Pengjiao Ma, Chuhan Wang, Chunxi Zhang, Jing Suo, Lang Bao
Genetic variations among genes of Mycobacterium tuberculosis may be associated with antigenic variation and immune evasion, which complicates the pathogenesis of M. tuberculosis. The hyper-virulent M. tuberculosis Beijing strains harbored several large sequence deletions, among which RD207 attributed to the deletion of CRISPR loci and several Cas genes. RD207 also gave rise to a truncated gene Rv2820c-Bj with 60% deletion in length at the 3'-end and a new 3'-end of five amino acid mutations. It has been reported that Rv2820c-Bj correlated with enhanced intracellular survival of M...
April 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29378712/a-10-year-comparative-analysis-shows-that-increasing-prevalence-of-rifampin-resistant-mycobacterium-tuberculosis-in-china-is-associated-with-the-transmission-of-strains-harboring-compensatory-mutations
#10
Fengmin Huo, Jingjing Luo, Jin Shi, Zhaojing Zong, Wei Jing, Wenzhu Dong, Lingling Dong, Yifeng Ma, Qian Liang, Yuanyuan Shang, Hairong Huang, Yu Pang
In this work, we conducted bacterial population profile studies to assess trends of rifampin (RIF) resistance of Mycobacterium tuberculosis isolates collected across China from 2005 to 2015. Totals of 273 and 269 randomly selected M. tuberculosis isolates from 2005 and 2015, respectively, were analyzed. The rates of RIF resistance (36.4%), isoniazid resistance (39.0%), and levofloxacin resistance (25.7%) in 2015 were significantly higher than those in 2005 (28.2%, 30.0%, and 15.4%, respectively; P < 0.05)...
April 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29335553/mutations-in-ppe38-block-pe_pgrs-secretion-and-increase-virulence-of-mycobacterium-tuberculosis
#11
Louis S Ates, Anzaan Dippenaar, Roy Ummels, Sander R Piersma, Aniek D van der Woude, Kim van der Kuij, Fabien Le Chevalier, Dulce Mata-Espinosa, Jorge Barrios-Payán, Brenda Marquina-Castillo, Carolina Guapillo, Connie R Jiménez, Arnab Pain, Edith N G Houben, Robin M Warren, Roland Brosch, Rogelio Hernández-Pando, Wilbert Bitter
Mycobacterium tuberculosis requires a large number of secreted and exported proteins for its virulence, immune modulation and nutrient uptake. Most of these proteins are transported by the different type VII secretion systems1,2 . The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus3,4 . However, the role of these proteins remains largely elusive 1 ...
February 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29334710/-a-study-on-genotype-of-271-mycobacterium-tuberculosis-isolates-in-6-prefectures-in-yunnan-province
#12
L Y Chen, X Yang, H H Ru, H J Yang, S Q Yan, L Ma, J O Chen, R Yang, L Xu
Objective: To understand the characteristics of genotypes of Mycobacterium tuberculosis isolates in Yunnan province, and provide the molecular epidemiological evidence for prevention and control of tuberculosis in Yunnan Province. Methods: Mycobacterium Tuberculosis isolates were collected from 6 prefectures of Yunnan province in 2014 and their Genetypes of Mycobacterium tuberculosis isolates were obtained using spoligotyping and multiple locus variable numbers of tandem repeats analysis (MLVA). The results of spoligotyping were entered into the SITVITWEB database to obtain the Spoligotyping International Type (SIT) patterns and the sublineages of MTB isolates...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29310751/multi-clonal-evolution-of-multi-drug-resistant-extensively-drug-resistant-mycobacterium-tuberculosis-in-a-high-prevalence-setting-of-papua-new-guinea-for-over-three-decades
#13
Arnold Bainomugisa, Evelyn Lavu, Stenard Hiashiri, Suman Majumdar, Alice Honjepari, Rendi Moke, Paison Dakulala, Grant A Hill-Cawthorne, Sushil Pandey, Ben J Marais, Chris Coulter, Lachlan Coin
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 of 165 clinical isolates referred from Daru General Hospital to the Supranational reference laboratory, Brisbane, during 2012-2015 revealed that 95 belonged to a single modern Beijing sub-lineage strain. Molecular dating suggested acquisition of streptomycin and isoniazid resistance in the 1960s, with potentially enhanced virulence mediated by an mycP1 mutation...
January 4, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29297425/extensively-drug-resistant-tuberculosis-in-myanmar-burden-and-mutations-causing-second-line-drug-resistance
#14
P W Ei, W W Aung, W W Nyunt, T L Swe, M M Htwe, S M Win, S T Aung, C L Chang, H-Y Lee, J S Lee
SETTING: Two tuberculosis (TB) reference laboratories in Myanmar. OBJECTIVES: To determine the proportion of extensively drug-resistant TB (XDR-TB) cases among multidrug-resistant TB (MDR-TB) cases and the mutations that cause resistance to second-line drugs in Myanmar. DESIGN: This was a cross-sectional, retrospective study. Multidrug-resistant Mycobacterium tuberculosis isolates were collected during 2015-2016. Phenotypic drug susceptibility testing (DST) was performed and drug-resistant mutations identified by sequencing...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29288283/associations-between-mycobacterium-tuberculosis-beijing-genotype-and-drug-resistance-to-four-first-line-drugs-a-survey-in-china
#15
Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan
Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M. tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China...
February 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29250048/molecular-characterization-of-prothionamide-resistant-mycobacterium-tuberculosis-isolates-in-southern-china
#16
Yaoju Tan, Biyi Su, Huiwen Zheng, Yuanyuan Song, Yufeng Wang, Yu Pang
Prothionamide (PTH) has been widely used in the treatment of tuberculosis (TB), especially multidrug resistant tuberculosis (MDR-TB), while data regarding prevalence of resistance-causing mutation is limited. In this study, we aimed to investigate the molecular characteristics of PTH-resistant MTB isolates, and also analyzed the risk factors for PTH resistance among Mycobacterium tuberculosis (MTB) isolates in southern China. A total of 282 MTB isolates were enrolled in from Guangzhou Chest Hospital. Among these isolates, 46 (16...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29233106/genetic-diversity-and-distribution-of-mycobacterium-tuberculosis-genotypes-in-limpopo-south-africa
#17
N T C Maguga-Phasha, N S Munyai, F Mashinya, M E Makgatho, E F Mbajiorgu
BACKGROUND: Tuberculosis remains a major health problem and knowledge of the diversity of Mycobacterium tuberculosis strains in specific geographical regions can contribute to the control of the disease. This study describes the genetic profile of M. tuberculosis in five districts of Limpopo Province. METHODS: A total 487 isolates were collected from the National Health Laboratory Services from all regions/districts of Limpopo Province. Only 215 isolates were confirmed to be M...
December 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29168460/molecular-genetic-characteristics-of-mycobacterium-tuberculosis-strains-circulating-in-the-southern-part-of-west-siberia
#18
Oksana Pasechnik, Maya Alexandrovna Dymova, Vladimir Leonidovich Stasenko, Aleksey Igorevich Blokh, Marina Petrovna Tatarintseva, Lyubov Pavlovna Kolesnikova, Maksim Leonidovich Filipenko
BACKGROUND & OBJECTIVES: A complicated epidemiological situation characterized by significantly high tuberculosis (TB) morbidity is observed in West Siberia. This study was aimed to investigate the genetic characteristics of Mycobacterium tuberculosis circulating in the southern part of West Siberia (in the Omsk region). METHODS: From March 2013 to January 2015, 100 isolates of M. tuberculosis were obtained from patients with pulmonary TB living in the Omsk region...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29151338/genotype-distribution-of-mycobacterium-tuberculosis-in-theaegean-region-and-associated-demographic-factors
#19
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz, İsabel Raika Durusoy Onmuş, Tuğba Bozdemir, Hüseyin Taşlı, Mine Hoşgör Limoncu
Background/aim: The Aegean Region is the second-ranking region in Turkey according to the Human Development Index and population density and it hosts 1/8 of Turkey's population. İzmir is the largest city of the region, receiving internal migration both from inside and outside the region. The tuberculosis incidence in İzmir is lower than overall in Turkey: 17.7/100,000 in 2011. Our aims were to determine genotypes of Mycobacterium tuberculosis isolates; to explore possible associations between genotypes with case-demographic data, clinical presentation, and antimicrobial susceptibility patterns; and to determine variations in genotype distribution of strains isolated in Ege University Hospital, İzmir...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29142045/rapid-assay-for-detection-of-the-epidemiologically-important-central-asian-russian-strain-of-the-mycobacterium-tuberculosis-beijing-genotype
#20
LETTER
Igor Mokrousov, Ekaterina Chernyaeva, Anna Vyazovaya, Yuriy Skiba, Natalia Solovieva, Violeta Valcheva, Klavdia Levina, Natalya Malakhova, Wei-Wei Jiao, Lia Lima Gomes, Philip N Suffys, Marge Kütt, Nagima Aitkhozhina, A-Dong Shen, Olga Narvskaya, Viacheslav Zhuravlev
No abstract text is available yet for this article.
February 2018: Journal of Clinical Microbiology
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