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https://www.readbyqxmd.com/read/28526067/the-chimeric-monoclonal-antibody-mhcsz-123-against-human-von-willebrand-factor-a3-domain-inhibits-high-shear-arterial-thrombosis-in-a-rhesus-monkey-model
#1
Shundong Ji, Miao Jiang, Bin Yan, Fei Shen, Yang He, Aini Wan, Lijun Xia, Changgeng Ruan, Yiming Zhao
BACKGROUND: SZ-123, a murine monoclonal antibody that targets the human von Willebrand factor (VWF) A3 domain and blocks the binding of collagen, is a powerful antithrombotic. In a Rhesus monkey model of thrombosis, SZ-123 had no side effects, such as bleeding or thrombocytopenia. METHODS: The mouse/human chimeric version of SZ-123, MHCSZ-123, was developed and maintained inhibitory capacities in vitro and ex vivo after injection into monkeys. CHO-S cells were selected for stable expression of MHCSZ-123...
May 19, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28511408/estimation-of-total-length-of-femur-from-its-proximal-and-distal-segmental-measurements-of-disarticulated-femur-bones-of-nepalese-population-using-regression-equation-method
#2
Laxman Khanal, Sandip Shah, Sarun Koirala
INTRODUCTION: Length of long bones is taken as an important contributor for estimating one of the four elements of forensic anthropology i.e., stature of the individual. Since physical characteristics of the individual differ among different groups of population, population specific studies are needed for estimating the total length of femur from its segment measurements. AIM: Since femur is not always recovered intact in forensic cases, it was the aim of this study to derive regression equations from measurements of proximal and distal fragments in Nepalese population...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506299/developmental-hip-dysplasia-treated-by-total-hip-arthroplasty-using-a-cementless-wagner-cone-stem-in-young-adult-patients-with-a-small-physique
#3
Ping Zhen, Jun Liu, Hao Lu, Hui Chen, Xusheng Li, Shenghu Zhou
BACKGROUND: Developmental hip dysplasia (DDH) may lead to severe acetabular and femoral abnormalities that can render total hip arthroplasty (THA) challenging, especially in DDH patients with a small physique. Most conventional cemented or cementless femoral components are often difficult to implant in the narrow femoral canal and require slight version correction during surgery. The aim of this study was to present the mid-term results of THA in the treatment of DDH patients with a small physique using a cementless Wagner cone prosthesis (Zimmer®, US)...
May 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28504114/a-shortened-tamoxifen-induction-scheme-to-induce-creer-recombinase-without-side-effects-on-the-male-mouse-skeleton
#4
Ferran Jardí, Michaël R Laurent, Vanessa Dubois, Rougin Khalil, Ludo Deboel, Dieter Schollaert, Ludo Van Den Bosch, Brigitte Decallonne, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren
The selective estrogen receptor modulator tamoxifen exerts estrogen agonistic or antagonistic actions on several tissues, including bone. The off-target effects of tamoxifen are one of the most widely recognized pitfalls of tamoxifen-inducible Cre recombinases (CreERs), potentially confounding the phenotypic findings. Still, the validation of tamoxifen induction schemes that minimize the side effects of the drug has not been addressed. Here, we compared the side effects on the skeleton and other androgen-responsive targets of a shortened tamoxifen regimen (2 doses of 190 mg/kg body weight by oral gavage) to a standard protocol (4 doses) and determined their efficiency in inducing CreER-mediated gene deletion...
May 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28460693/triple-pelvic-osteotomy-and-double-pelvic-osteotomy
#5
REVIEW
Francisco Guevara, Samuel P Franklin
Triple and double pelvic osteotomy (TPO, DPO) are performed with the goal of increasing acetabular ventro-version, increasing femoral head coverage, and decreasing femoral head subluxation. Since the first descriptions of TPO, there have been modifications in technique, most notably omission of the ischial osteotomy for DPO, and improvements in the implants, including availability of locking TPO/DPO bone plates. Associated complication rates seem to have declined accordingly. The most salient questions regarding these procedures remain what selection criteria should be used to identify candidates and whether halting or preventing osteoarthritis is necessary to consider these surgeries clinically beneficial...
April 28, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28459415/frax-based-estimates-of-10-year-probability-of-hip-and-major-osteoporotic-fracture-among-adults-aged-40-and-over-united-states-2013-and-2014
#6
Anne C Looker, Neda Sarafrazi Isfahani, Bo Fan, John A Shepherd
BACKGROUND: The FRAX algorithm estimates the 10-year probability of hip and major osteoporotic (clinical spine, forearm, hip, or humerus) fracture for adults aged 40 and over. An expert panel developed criteria to define elevated FRAX probabilities for U.S. adults aged 50 and over. This report uses FRAX estimates from the National Health and Nutrition Examination Survey 2013-2014 to describe the hip and major osteoporotic fracture probability distribution (for adults aged 40 and over) and prevalence of elevated probabilities (for adults aged 50 and over) in the United States...
March 2017: National Health Statistics Reports
https://www.readbyqxmd.com/read/28448179/comparison-of-arterial-stiffness-in-preeclamptic-and-normotensive-pregnant-women-from-a-semi-rural-region-of-south-africa
#7
A Namugowa, J Iputo, J Wandabwa, A Meeme, G A B Buga
BACKGROUND: Preeclampsia is associated with arterial stiffness and endothelial dysfunction. The pathophysiology of arterial tone in preeclampsia has not been well described in rural African population, where the incidence is higher. OBJECTIVE: The aim of the study was to compare arterial tone of preeclamptic with pregnant normotensive women assessed with noninvasive techniques, using applanation tonometry with SphygmoCor. METHOD: This was a cross-sectional study...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28438455/lesser-trochanter-size-on-plain-anteroposterior-radiographs-correlates-with-native-femoral-anteversion
#8
Michael C Worlicek, Michael L Wörner, Benjamin S Craiovan, Florian Zeman, Joachim Grifka, Tobias F Renkawitz, Markus Weber
BACKGROUND: Assessing femoral version in orthopedic surgery is important for preoperative planning of total hip arthroplasty, especially for recognizing excessive anteversion or retroversion. The present study addressed the following: (1) Is the position of the lesser trochanter correlated to the femoral neck axis? (2) If so, may femoral version be assessed by means of plain pelvic radiographs? METHODS: Three-dimensional computed tomography scans of 60 patients undergoing minimally invasive cement-free total hip arthroplasty were retrospectively analyzed, particularly with regard to the relation between the femoral neck axis and the lesser trochanter, the femoral version, and the size of the projected lesser trochanter in different rotational positions...
April 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28413130/arthroscopic-treatment-of-labral-tears-of-the-hip-in-adolescents-patterns-of-clinical-presentation-intra-articular-derangements-radiological-associations-and-minimum-2-year-outcomes
#9
Sivashankar Chandrasekaran, Nader Darwish, Edwin O Chaharbakhshi, Parth Lodhia, Carlos Suarez-Ahedo, Benjamin G Domb
PURPOSE: To report on patterns of clinical presentation, intra-articular derangements, radiological associations, and minimum 2-year outcomes after hip arthroscopy (HA) in patients 18 years or younger. METHODS: This study was a retrospective case series on patients 18 years or younger who had undergone HA for labral tears that had failed nonoperative management from April 2008 to April 2013 with a minimum 2-year follow-up. Exclusion criteria were previous hip conditions or surgery...
April 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28400660/anthropometric-analysis-of-the-hip-joint-in-south-indian-population-using-computed-tomography
#10
Vetrivel Chezian Sengodan, Elangovan Sinmayanantham, J Saravana Kumar
BACKGROUND: Proximal femur has a significant functional modification on erect bipedal posture. Various proximal femoral parameters were analyzed in Western literature. This information was utilized in prosthetic designing. Implants designed for Western people are used in Indian patients undergoing hip surgeries such as internal fixation and replacement arthroplasty. MATERIALS AND METHODS: The study was done among 200 individuals (400 hips) with a normal hip joint after ethical committee clearance...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28395388/results-of-a-modular-femoral-revision-system-before-and-after-taper-roller-hardening-in-total-hip-arthroplasty
#11
Dean J Marshall, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
INTRODUCTION: Modular component options can aid in addressing complex femoral reconstructions in total hip arthroplasty (THA) by allowing for customization of version control and proximal to distal sizing. However, component breakage at the modular junction has occurred, particularly in the presence of poor bone stock. A taper roller hardening (RH) process was developed to strengthen the modular junction to reduce breakage. The purpose of this study is to review THA patients before and after taper roller hardening to compare stem survival and frequency of breakage...
April 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28385931/total-hip-arthroplasty-using-a-monobloc-cementless-femoral-stem-for-patients-with-childhood-perthes-disease
#12
K H Lee, W-L Jo, Y C Ha, Y K Lee, S B Goodman, K H Koo
AIMS: Modular or custom-made femoral components have been preferred for total hip arthroplasty (THA) in patients with a history of Perthes' disease because of the distortion in the anatomy of the proximal femur. However, it has not been established whether a monobloc cementless stem will fit the distorted proximal femur or whether the results of the procedure are satisfactory in this group of patients. PATIENTS AND METHODS: We reviewed 68 consecutive patients who had undergone THA for childhood Perthes' disease between June 2003 and December 2008...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28385930/decreased-and-increased-relative-acetabular-volume-predict-the-development-of-osteoarthritis-of-the-hip-an-osteological-review-of-1090-hips
#13
D S Weinberg, D F K Williamson, M B Millis, R W Liu
AIMS: Recently, there has been considerable interest in quantifying the associations between bony abnormalities around and in the hip joint and osteoarthritis (OA). Our aim was to investigate the relationships between acetabular undercoverage, acetabular overcoverage, and femoroacetabular impingement (FAI) with OA of the hip, which currently remain controversial. MATERIALS AND METHODS: A total of 545 cadaveric skeletons (1090 hips) from the Hamann-Todd osteological collection were obtained...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28377989/spatial-heterogeneity-in-the-canalicular-density-of-the-osteocyte-network-in-human-osteons
#14
Felix Repp, Philip Kollmannsberger, Andreas Roschger, Michael Kerschnitzki, Andrea Berzlanovich, Gerlinde M Gruber, Paul Roschger, Wolfgang Wagermaier, Richard Weinkamer
Osteocytes interconnect with each other forming an intricate cell network within the mineralized bone matrix. One important function of the osteocyte network is the mechano-regulation of bone remodeling, where a possible mechanism includes the fluid flow through the porosity housing the cell network - the osteocyte lacuno-canalicular network (OLCN). In our study the OLCN in human osteons was three-dimensionally imaged with the aim to obtain a quantitative description of the canalicular density and spatial variations of this quantity within osteons...
June 2017: Bone Reports
https://www.readbyqxmd.com/read/28377262/evaluation-of-malrotation-following-intramedullary-nailing-in-a-femoral-shaft-fracture-model-can-a-3d-c-arm-improve-accuracy
#15
Austin J Ramme, Jonathan Egol, Gregory Chang, Roy I Davidovitch, Sanjit Konda
INTRODUCTION: Difficulty determining anatomic rotation following intramedullary (IM) nailing of the femur continues to be problematic for surgeons. Clinical exam and fluoroscopic imaging of the hip and knee have been used to estimate femoral version, but are inaccurate. We hypothesize that 3D c-arm imaging can be used to accurately measure femoral version following IM nailing of femur fractures to prevent rotational malreduction. METHODS: A midshaft osteotomy was created in a femur Sawbone to simulate a transverse diaphyseal fracture...
March 31, 2017: Injury
https://www.readbyqxmd.com/read/28376828/all-polyethylene-tibial-components-in-distal-femur-limb-salvage-surgery-a-finite-element-analysis-based-on-promising-clinical-outcomes
#16
Fan Tang, Yong Zhou, Wenli Zhang, Li Min, Rui Shi, Yi Luo, Hong Duan, Chongqi Tu
BACKGROUND: Whether all-polyethylene tibial (APT) components are beneficial to patients who received distal femur limb-salvage surgery lacks high-quality clinical follow-up and mechanical evidence. This study aimed to investigate the biomechanics of the distal femur reconstructed with APT tumor knee prostheses using finite element (FE) analysis based on our previous, promising clinical outcome. METHODS: Three-dimensional FE models that use APT and metal-backed tibial (MBT) prostheses to reconstruct distal femoral bone defects were developed and input into the Abaqus FEA software version 6...
April 4, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28375671/outcome-in-design-specific-comparisons-between-highly-crosslinked-and-conventional-polyethylene-in-total-hip-arthroplasty
#17
Per-Erik Johanson, Ove Furnes, Leif Ivar Havelin, Anne Marie Fenstad, Alma B Pedersen, Søren Overgaard, Göran Garellick, Keijo Mäkelä, Johan Kärrholm
Background and purpose - Most registry studies regarding highly crosslinked polyethylene (XLPE) have focused on the overall revision risk. We compared the risk of cup and/or liner revision for specific cup and liner designs made of either XLPE or conventional polyethylene (CPE), regarding revision for any reason and revision due to aseptic loosening and/or osteolysis. Patients and methods - Using the Nordic Arthroplasty Register Association (NARA) database, we identified cup and liner designs where either XLPE or CPE had been used in more than 500 THAs performed for primary hip osteoarthritis...
April 4, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28365071/trochanteric-entry-femoral-nails-yield-better-femoral-version-and-lower-revision-rates-a-large-cohort-multivariate-regression-analysis
#18
Richard S Yoon, Mark J Gage, David K Galos, Derek J Donegan, Frank A Liporace
INTRODUCTION: Intramedullary nailing (IMN) has become the standard of care for the treatment of most femoral shaft fractures. Different IMN options include trochanteric and piriformis entry as well as retrograde nails, which may result in varying degrees of femoral rotation. The objective of this study was to analyze postoperative femoral version between three types of nails and to delineate any significant differences in femoral version (DFV) and revision rates. MATERIALS & METHODS: Over a 10-year period, 417 patients underwent IMN of a diaphyseal femur fracture (AO/OTA 32A-C)...
March 18, 2017: Injury
https://www.readbyqxmd.com/read/28351208/angiographic-dissection-patterns-and-patency-outcomes-after-balloon-angioplasty-for-superficial-femoral-artery-disease
#19
Masahiko Fujihara, Mitsuyoshi Takahara, Shinya Sasaki, Kiyonori Nanto, Makoto Utsunomiya, Osamu Iida, Yoshiaki Yokoi
PURPOSE: To investigate the angiographic dissection patterns after balloon angioplasty for superficial femoral artery (SFA) lesions, the clinical outcome associated with each dissection pattern, and the predictive factors for severe dissection. METHODS: A retrospective, multicenter analysis examined 621 patients (mean age 72.8±9.5 years; 414 men) with 748 symptomatic de novo SFA lesions treated with endovascular therapy. Vessel dissection after the initial balloon angioplasty procedure was graded into 7 types according to a modified version of the coronary artery classification types A to F...
March 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28348929/curvature-reduces-bending-strains-in-the-quokka-femur
#20
Kyle McCabe, Keith Henderson, Jess Pantinople, Hazel L Richards, Nick Milne
This study explores how curvature in the quokka femur may help to reduce bending strain during locomotion. The quokka is a small wallaby, but the curvature of the femur and the muscles active during stance phase are similar to most quadrupedal mammals. Our hypothesis is that the action of hip extensor and ankle plantarflexor muscles during stance phase place cranial bending strains that act to reduce the caudal curvature of the femur. Knee extensors and biarticular muscles that span the femur longitudinally create caudal bending strains in the caudally curved (concave caudal side) bone...
2017: PeerJ
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