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https://www.readbyqxmd.com/read/28912838/phylogenomics-of-colombian-helicobacter-pylori-isolates
#1
Andrés Julián Gutiérrez-Escobar, Esperanza Trujillo, Orlando Acevedo, María Mercedes Bravo
BACKGROUND: During the Spanish colonisation of South America, African slaves and Europeans arrived in the continent with their corresponding load of pathogens, including Helicobacter pylori. Colombian strains have been clustered with the hpEurope population and with the hspWestAfrica subpopulation in multilocus sequence typing (MLST) studies. However, ancestry studies have revealed the presence of population components specific to H. pylori in Colombia. The aim of this study was to perform a thorough phylogenomic analysis to describe the evolution of the Colombian urban H...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28912065/taino-and-african-maternal-heritage-in-the-greater-antilles
#2
Areej Bukhari, Javier Rodriguez Luis, Miguel A Alfonso-Sanchez, Ralph Garcia-Bertrand, Rene J Herrera
Notwithstanding the general interest and the geopolitical importance of the island countries in the Greater Antilles, little is known about the specific ancestral Native American and African populations that settled them. In an effort to alleviate this lacuna of information on the genetic constituents of the Greater Antilles, we comprehensively compared the mtDNA compositions of Cuba, Dominican Republic, Haiti, Jamaica and Puerto Rico. To accomplish this, the mtDNA HVRI and HVRII regions, as well as coding diagnostic sites, were assessed in the Haitian general population and compared to data from reference populations...
September 11, 2017: Gene
https://www.readbyqxmd.com/read/28864458/optimizing-genomic-medicine-in-epilepsy-through-a-gene-customized-approach-to-missense-variant-interpretation
#3
Joshua Traynelis, Michael Silk, Quanli Wang, Samuel F Berkovic, Liping Liu, David B Ascher, David J Balding, Slavé Petrovski
Gene panel and exome sequencing have revealed a high rate of molecular diagnoses among diseases where the genetic architecture has proven suitable for sequencing approaches, with a large number of distinct and highly penetrant causal variants identified among a growing list of disease genes. The challenge is, given the DNA sequence of a new patient, to distinguish disease-causing from benign variants. Large samples of human standing variation data highlight regional variation in the tolerance to missense variation within the protein-coding sequence of genes...
September 1, 2017: Genome Research
https://www.readbyqxmd.com/read/28854056/bdsm-role-fluidity-a-mixed-methods-approach-to-investigating-switches-within-dominant-submissive-binaries
#4
Katherine Martinez
This mixed-methods study of BDSM investigates the nuances of BDSM participants' role identities, role frequencies, and role fluidities-shifts in identities and play across time, location, scene, and play partner. Data were gathered from 202 online surveys and 25 semi-structured interviews about participants' roles given their gender and sexual identities. These data reveal that men tend to self-identify as Dominant, Master, Top, or Sadist (DMTS) and always perform dominant roles, while women tend to self-identify as Submissive, Slave, Bottom, or Masochist (SSBM) and always perform submissive roles...
August 30, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28843552/calibration-transfer-of-a-raman-spectroscopic-quantification-method-for-the-assessment-of-liquid-detergent-compositions-between-two-at-line-instruments-installed-at-two-liquid-detergent-production-plants
#5
D Brouckaert, J-S Uyttersprot, W Broeckx, T De Beer
Calibration transfer of partial least squares (PLS) quantification models is established between two Raman spectrometers located at two liquid detergent production plants. As full recalibration of existing calibration models is time-consuming, labour-intensive and costly, it is investigated whether the use of mathematical correction methods requiring only a handful of standardization samples can overcome the dissimilarities in spectral response observed between both measurement systems. Univariate and multivariate standardization approaches are investigated, ranging from simple slope/bias correction (SBC), local centring (LC) and single wavelength standardization (SWS) to more complex direct standardization (DS) and piecewise direct standardization (PDS)...
September 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28829318/event-based-impulsive-control-of-continuous-time-dynamic-systems-and-its-application-to-synchronization-of-memristive-neural-networks
#6
Wei Zhu, Dandan Wang, Lu Liu, Gang Feng
This paper investigates exponential stabilization of continuous-time dynamic systems (CDSs) via event-based impulsive control (EIC) approaches, where the impulsive instants are determined by certain state-dependent triggering condition. The global exponential stability criteria via EIC are derived for nonlinear and linear CDSs, respectively. It is also shown that there is no Zeno-behavior for the concerned closed loop control system. In addition, the developed event-based impulsive scheme is applied to the synchronization problem of master and slave memristive neural networks...
August 18, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28822183/-application-of-dosc-combined-with-sbc-in-batches-transfer-of-nir-quantitative-model
#7
Yi-Fei Jia, Ying-Ying Zhang, Bing Xu, An-Dong Wang, Xue-Yan Zhan
Near infrared model established under a certain condition can be applied to the new samples status, environmental conditions or instrument status through the model transfer. Spectral background correction and model update are two types of data process methods of NIR quantitative model transfer, and orthogonal signal regression (OSR) is a method based on spectra background correction, in which virtual standard spectra is used to fit a linear relation between master batches spectra and slave batches spectra, and map the slave batches spectra to the master batch spectra to realize the transfer of near infrared quantitative model...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28797091/orion-detecting-regions-of-the-human-non-coding-genome-that-are-intolerant-to-variation-using-population-genetics
#8
Ayal B Gussow, Brett R Copeland, Ryan S Dhindsa, Quanli Wang, Slavé Petrovski, William H Majoros, Andrew S Allen, David B Goldstein
There is broad agreement that genetic mutations occurring outside of the protein-coding regions play a key role in human disease. Despite this consensus, we are not yet capable of discerning which portions of non-coding sequence are important in the context of human disease. Here, we present Orion, an approach that detects regions of the non-coding genome that are depleted of variation, suggesting that the regions are intolerant of mutations and subject to purifying selection in the human lineage. We show that Orion is highly correlated with known intolerant regions as well as regions that harbor putatively pathogenic variation...
2017: PloS One
https://www.readbyqxmd.com/read/28794409/annotating-pathogenic-non-coding-variants-in-genic-regions
#9
Sahar Gelfman, Quanli Wang, K Melodi McSweeney, Zhong Ren, Francesca La Carpia, Matt Halvorsen, Kelly Schoch, Fanni Ratzon, Erin L Heinzen, Michael J Boland, Slavé Petrovski, David B Goldstein
Identifying the underlying causes of disease requires accurate interpretation of genetic variants. Current methods ineffectively capture pathogenic non-coding variants in genic regions, resulting in overlooking synonymous and intronic variants when searching for disease risk. Here we present the Transcript-inferred Pathogenicity (TraP) score, which uses sequence context alterations to reliably identify non-coding variation that causes disease. High TraP scores single out extremely rare variants with lower minor allele frequencies than missense variants...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28793858/mtdna-structure-the-women-who-formed-the-brazilian-northeast
#10
Ana Paula Schaan, Lorenna Costa, Diego Santos, Antonio Modesto, Marcos Amador, Camile Lopes, Sílvia Helena Rabenhorst, Raquel Montenegro, Bruno D A Souza, Thayson Lopes, France Keiko Yoshioka, Giovanny Pinto, Vivian Silbiger, Ândrea Ribeiro-Dos-Santos
BACKGROUND: The distribution of mitochondrial DNA (mtDNA) lineages in Brazil is heterogeneous due to different regional colonization dynamics. Northeastern Brazil, although being an important region in terms of human imigration and ethnic admixture, has little information regarding its population mtDNA composition. Here, we determine which mitochondrial lineages contributed to the formation of the Northeastern Brazilian population. Our sample consisted of 767 individuals distributed as follows i) 550 individuals from eight Northeastern states (Piauí, Ceará, Rio Grande do Norte, Paraíba, Pernambuco, Alagoas, Sergipe, and Bahia) which were sequenced for mtDNA hypervariable segments I, II, and III; ii) 217 individuals from Alagoas and Pernambuco (previously published data)...
August 9, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28767384/distributed-differential-evolution-based-on-adaptive-mergence-and-split-for-large-scale-optimization
#11
Yong-Feng Ge, Wei-Jie Yu, Ying Lin, Yue-Jiao Gong, Zhi-Hui Zhan, Wei-Neng Chen, Jun Zhang
Nowadays, large-scale optimization problems are ubiquitous in many research fields. To deal with such problems efficiently, this paper proposes a distributed differential evolution with adaptive mergence and split (DDE-AMS) on subpopulations. The novel mergence and split operators are designed to make full use of limited population resource, which is important for large-scale optimization. They are adaptively performed based on the performance of the subpopulations. During the evolution, once a subpopulation finds a promising region, the current worst performing subpopulation will merge into it...
July 31, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28762253/intraocular-robotic-interventional-surgical-system-iriss-mechanical-design-evaluation-and-master-slave-manipulation
#12
Jason T Wilson, Matthew J Gerber, Stephen W Prince, Cheng-Wei Chen, Steven D Schwartz, Jean-Pierre Hubschman, Tsu-Chin Tsao
BACKGROUND: Since the advent of robotic-assisted surgery, the value of using robotic systems to assist in surgical procedures has been repeatedly demonstrated. However, existing technologies are unable to perform complete, multi-step procedures from start to finish. Many intraocular surgical steps continue to be manually performed. METHODS: An intraocular robotic interventional surgical system (IRISS) capable of performing various intraocular surgical procedures was designed, fabricated, and evaluated...
July 31, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28758326/a-novel-optimal-coordinated-control-strategy-for-the-updated-robot-system-for-single-port-surgery
#13
Weibang Bai, Qixin Cao, Chuntao Leng, Yang Cao, Masakatsu G Fujie, Tiewen Pan
BACKGROUND: Research into robotic systems for single port surgery (SPS) has become widespread around the world in recent years. A new robot arm system for SPS was developed, but its positioning platform and other hardware components were not efficient. Special features of the developed surgical robot system make good teleoperation with safety and efficiency difficult. METHODS: A robot arm is combined and used as new positioning platform, and the remote center motion is realized by a new method using active motion control...
July 30, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28755945/standardization-of-milk-mid-infrared-spectrometers-for-the-transfer-and-use-of-multiple-models
#14
C Grelet, J A Fernández Pierna, P Dardenne, H Soyeurt, A Vanlierde, F Colinet, C Bastin, N Gengler, V Baeten, F Dehareng
An increasing number of models are being developed to provide information from milk Fourier transform mid-infrared (FT-MIR) spectra on fine milk composition, technological properties of milk, or even cows' physiological status. In this context, and to take advantage of these existing models, the purpose of this work was to evaluate whether a spectral standardization method can enable the use of multiple equations within a network of different FT-MIR spectrometers. The piecewise direct standardization method was used, matching "slave" instruments to a common reference, the "master...
July 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28726517/robot-assisted-tumor-resection-devices
#15
Yutaka Saito, Kazuki Sumiyama, Philip Wai Yan
In Japan, colorectal endoscopic submucosal dissection (ESD) is being conducted safely and effectively as shown by the increased number of the cases, however, it is still regarded as a complicated and challenging procedure. Therefore, piecemeal endoscopic mucosal resection (p-EMR) is still regarded as an appropriate treatment, rather than ESD for large colorectal tumors, especially in Western countries. Areas covered: There are several factors that are responsible for colorectal ESD difficulty. Firstly, there is no adequate traction or counter-traction in colorectal ESD...
July 20, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28717674/exactly-zero-or-once-a-clinically-helpful-guide-to-assessing-genetic-variants-in-mild-epilepsies
#16
Caitlin A Bennett, Slavé Petrovski, Karen L Oliver, Samuel F Berkovic
OBJECTIVE: To assist the interpretation of genomic data for common epilepsies, we asked whether variants implicated in mild epilepsies in autosomal dominant families are present in the general population. METHODS: We studied 12 genes for the milder epilepsies and identified published variants with strong segregation support (de novo germline mutation or ≥4 affected family members). These variants were checked in the Exome Aggregation Consortium (ExAC), a database of genetic variation in over 60,000 individuals...
August 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28708842/evaluating-whole-genome-sequence-data-from-the-genetic-absence-epilepsy-rat-from-strasbourg-and-its-related-non-epileptic-strain
#17
Pablo M Casillas-Espinosa, Kim L Powell, Mingfu Zhu, C Ryan Campbell, Jessica M Maia, Zhong Ren, Nigel C Jones, Terence J O'Brien, Slavé Petrovski
OBJECTIVE: The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are an inbreed Wistar rat strain widely used as a model of genetic generalised epilepsy with absence seizures. As in humans, the genetic architecture that results in genetic generalized epilepsy in GAERS is poorly understood. Here we present the strain-specific variants found among the epileptic GAERS and their related Non-Epileptic Control (NEC) strain. The GAERS and NEC represent a powerful opportunity to identify neurobiological factors that are associated with the genetic generalised epilepsy phenotype...
2017: PloS One
https://www.readbyqxmd.com/read/28698594/semantic-congruent-audiovisual-integration-during-the-encoding-stage-of-working-memory-an-erp-and-sloreta-study
#18
Yuanjun Xie, Yuanyuan Xu, Chen Bian, Min Li
Although multisensory integration is an inherent component of functional brain organization, multisensory integration during working memory (WM) has attracted little attention. The present study investigated the neural properties underlying the multisensory integration of WM by comparing semantically related bimodal stimulus presentations with unimodal stimulus presentations and analysing the results using the standardized low-resolution brain electromagnetic tomography (sLORETA) source location approach. The results showed that the memory retrieval reaction times during congruent audiovisual conditions were faster than those during unisensory conditions...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28675593/analysis-of-admixture-proportions-in-seven-geographical-regions-of-the-state-of-guerrero-mexico
#19
José Ángel Cahua-Pablo, Miguel Cruz, Pedro Vidal Tello-Almaguer, Luz Carmen Del Alarcón-Romero, Esteban Juan Parra, Salvador Villerías-Salinas, Adán Valladares-Salgado, Vianet Argelia Tello-Flores, Abigail Méndez-Palacios, Claudia Paola Pérez-Macedonio, Eugenia Flores-Alfaro
OBJECTIVE: Mexico's current population structure has been defined by admixture between European, Native American, and to some extent African, groups that started in the sixteenth century. The aim of this research was to analyze the relative contributions of these continental population groups to the seven regions of the state of Guerrero, Mexico. METHODS: A total of 104 ancestry informative markers were analyzed in 480 unrelated women from the seven regions of the state of Guerrero...
July 4, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28669415/global-disparities-in-maternal-morbidity-and-mortality
#20
Maria J Small, Terrence K Allen, Haywood L Brown
The disparity in maternal mortality for African American women remains one of the greatest public health inequities in the United States (US). To better understand approaches toward amelioration of these differences, we examine settings with similar disparities in maternal mortality and "near misses" based on race/ethnicity. This global analysis of disparities in maternal mortality/morbidity will focus on middle- and high-income countries (based on World Bank definitions) with multiethnic populations. Many countries with similar histories of slavery and forced migration demonstrate disparities in health outcomes based on social determinants such as race/ethnicity...
August 2017: Seminars in Perinatology
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