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Charcot marie toth 1a

C Toth
BACKGROUND: Preclinical studies have suggested that ascorbic acid (AA) treatment in a mouse model of Charcot-Marie-Tooth type 1A (CMT1A) improves motor function and prolongs lifespan. AIMS: I sought to determine the safety and tolerability of AA in adult patients with CMT1A. METHODS: An open-label cohort-controlled 2-year pilot study was used to evaluate the tolerability of 5 g of AA daily. Secondary measurements consisted of clinical and electrophysiological measurements at 0, 12, and 24 months in CMT1A patients...
August 2009: Acta Neurologica Scandinavica
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