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Schizophrenia hormone

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https://www.readbyqxmd.com/read/29120013/primary-polydipsia-in-the-medical-and-psychiatric-patient-characteristics-complications-and-therapy
#1
Clara Sailer, Bettina Winzeler, Mirjam Christ-Crain
Primary polydipsia (PP) has been defined as excessive intake of fluids. However, the pathogenesis of PP remains unexplored. Different theories include a dysfunction in the thirst mechanism, involvement of the hippocampus, stress-reducing behaviour and lesion occurrences in specific areas of the brain. Most studies have been performed in the psychiatric setting, indicating that PP coincides with schizophrenia, anxiety disorder and depression. However, an increasing number of case reports emphasise the incidence of PP in non-psychiatric patients...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29082784/genderwise-clinical-response-of-antipsychotics-among-schizophrenic-patients-a-prospective-observational-study-from-lahore-pakistan
#2
Usama Asif, Zikria Saleem, Mahrukh Yousaf, Hamid Saeed, Furqan Khurshid Hashmi, Muhammad Islam, Mohamed Azmi Hassali, Fahad Saleem
OBJECTIVE: The study was aimed to evaluate the gender specific response to adherence and occurrence of side effects among schizophrenic patients in Lahore, Pakistan. METHODS: A prospective study was performed for a period of 1 year among 180 newly diagnosed schizophrenics, aged 20-60 years to observe the symptoms, medication adherence and side effects. MMAS-4 was used to evaluate medication adherence, LUNSER for side effects and PANSS to measure positive and negative symptoms...
October 30, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29067802/ultrasensitive-and-selective-organic-fet-type-nonenzymatic-dopamine-sensor-based-on-platinum-nanoparticles-decorated-reduced-graphene-oxide
#3
Jungkyun Oh, Jun Seop Lee, Jaemoon Jun, Sung Gun Kim, Jyongsik Jang
Dopamine (DA), a catecholamine hormone, is an important neurotransmitter that controls renal and cardiovascular organizations and regulates physiological activities. Abnormal concentrations of DA cause unfavorable neuronal illnesses such as Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder/attention deficit disorder. However, the DA concentration is exceedingly low in patients and difficult to detect with existing biosensors. In this study, we developed an organic field-effect-transistor-type (OFET) nonenzyme biosensor using platinum nanoparticle-decorated reduced graphene oxide (Pt_rGO) for ultrasensitive and selective DA detection...
November 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29033027/anhedonia-following-early-life-adversity-involves-aberrant-interaction-of-reward-and-anxiety-circuits-and-is-reversed-by-partial-silencing-of-amygdala-corticotropin-releasing-hormone-gene
#4
Jessica L Bolton, Jenny Molet, Limor Regev, Yuncai Chen, Neggy Rismanchi, Elizabeth Haddad, Derek Z Yang, Andre Obenaus, Tallie Z Baram
BACKGROUND: Anhedonia, the diminished ability to experience pleasure, is an important dimensional entity linked to depression, schizophrenia, and other emotional disorders, but its origins and mechanisms are poorly understood. We have previously identified anhedonia, manifest as decreased sucrose preference and social play, in adolescent male rats that experienced chronic early-life adversity/stress (CES). Here we probed the molecular, cellular, and circuit processes underlying CES-induced anhedonia and tested them mechanistically...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29021759/effects-of-gladiolus-dalenii-on-the-stress-induced-behavioral-neurochemical-and-reproductive-changes-in-rats
#5
David Fotsing, Gwladys T Ngoupaye, Agnes C Ouafo, Stephanie K J Njapdounke, Yongabi A Kenneth, Elisabeth Ngo Bum
Gladiolus dalenii is a plant commonly used in many regions of Cameroon as a cure for various diseases like headaches, epilepsy, schizophrenia, and mood disorders. Recent studies have revealed that the aqueous extract of G. dalenii (AEGD) exhibited antidepressant-like properties in rats. Therefore, we hypothesized that the AEGD could protect from the stress-induced behavioral, neurochemical, and reproductive changes in rats. The objective of the present study was to elucidate the effect of the AEGD on behavioral, neurochemical, and reproductive characteristics, using female rats subjected to chronic immobilization stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28966571/cross-talk-the-microbiota-and-neurodevelopmental-disorders
#6
REVIEW
John R Kelly, Chiara Minuto, John F Cryan, Gerard Clarke, Timothy G Dinan
Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut microbiota can signal to the brain via the immune system, the vagus nerve or other host-microbe interactions facilitated by gut hormones, regulation of tryptophan metabolism and microbial metabolites such as short chain fatty acids (SCFA), to influence brain development, function and behavior. Emerging evidence suggests that the gut microbiota may play a role in shaping cognitive networks encompassing emotional and social domains in neurodevelopmental disorders...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28953849/the-role-of-hormones-and-inflammatory-markers-in-cognitive-functioning-of-schizophrenic-patients
#7
Krzysztof Krysta, Marek Krzystanek, Wiesław J Cubała, Mariusz S Wiglusz, Katarzyna Jakuszkowiak-Wojten, Maria Gałuszko-Węgielnik, Monika Czarnowska-Cubała, Joanna Szarmach, Adam Włodarczyk, Małgorzata Janas-Kozik
BACKGROUND: In the literature we can find evidence that immunological processes are involved the alterations of cognition in schizophrenic patients. Another factor, which may have an impact on cognitive domains in this clinical group are hormones. OBJECTIVE: The objective of this review was to explore studies, in which the role of both immunological and endocrine factors on cognitive functions in schizophrenia are analyzed. METHODS: The search of papers covering this topic in PubMed and Google Scholar was performed...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953846/does-risperidone-long-acting-injectable-depot-rlai-reduce-number-of-admissions-to-hospital
#8
Hellme Najim, Ashish Pathak, Andrea Pathak
BACKGROUND: Adherence to treatment is a major issue in relapse prevention in schizophrenia. Injectable depot has been claimed to improve non-adherence. A study in the North of England has shown that risperidone long acting injectable form has reduced number of admissions and number of days stayed in hospital. Our study aimed to replicate the previous study in the South of England. METHODS: A retrospective study was conducted in the South Essex Foundation University NHS trust...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953679/neuroleptic-malignant-syndrome-with-thyroid-disorder-an-unusual-case-report
#9
Fan Zhang, Parisa Kanzali, Vadim Rubin, Chris Paras, Joel Goldman
RATIONALE: Neuroleptic malignant syndrome (NMS) is a life threatening neurologic emergency associated with neuroleptic or antipsychotic agent use. NMS is rarely related to thyroid disease. PATIENT CONCERNS: We report a case of NMS in a 66-year-old male with past medical history of paranoid schizophrenia on chlorpromazine, diabetes, hypertension and asthma, who presented with a humeral fracture after a fall. Patient developed hyperpyrexia, altered consciousness, autonomic instability, elevated serum creatine kinase (CK) without rigidity...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28941299/considering-the-role-of-adolescent-sex-steroids-in-schizophrenia
#10
REVIEW
Samantha J Owens, Caitlin E Murphy, Tertia D Purves-Tyson, Thomas W Weickert, Cynthia Shannon Weickert
Schizophrenia is a disabling illness that is typically first diagnosed during late adolescence to early adulthood, has an unremitting course, and is often treatment resistance. Many clinical aspects of the illness suggest that sex steroid-nervous system interactions may contribute to the onset and course of symptoms and the cognitive impairment displayed by men and women with schizophrenia. Here, we discuss the actions of estrogen and testosterone on the brain during adolescent development and in schizophrenia from the perspective of experimental studies in animals, human post-mortem studies, magnetic resonance imaging studies in living humans, and clinical trials of sex steroid based treatments...
September 23, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28925886/the-microbiota-gut-brain-axis-in-neuropsychiatric-disorders-pathophysiological-mechanisms-and-novel-treatments
#11
Yong-Ku Kim, Cheolmin Shin
BACKGROUND: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. METHOD: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28830897/tsh-and-prl-side-effect-markers-in-aripiprazole-treatment-adjunctive-aripiprazole-induced-thyrotropin-oversuppression-in-a-young-man-with-schizophrenia
#12
Hidenobu Ohta, Satoru Inoue, Koichiro Hara, Akihiko Watanabe
A 26-year-old Japanese man was admitted to our unit with exacerbated paranoid schizophrenia. Prior to his admission, daily administration of olanzapine had been sufficient to maintain a partial remission of his schizophrenia, but due to an exacerbation of his delusions, he had then also been prescribed aripiprazole, which had been followed by no improvement in symptoms and a gradual further exacerbation of auditory delusions. Physical examinations, brain MRI and neurophysiological assessment were unremarkable...
August 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28728797/-prevalence-of-hypothyroidism-in-major-psychiatric-disorders-in-hospitalised-patients-in-montserrat-hospital-during-the-period-march-to-october-2010
#13
Pedro Vargas Navarro, Edgar Antonio Ibañez Pinilla, Alejandra Galeano España, Ana María Noguera Bravo, Sandra Milena Pantoja, Ana María Suárez Acosta
INTRODUCTION: Hypothyroidism results from inadequate production of thyroid hormone. It is known that there is a relationship between the major psychiatric disorders and hypothyroidism. OBJECTIVE: To determine the prevalence of hypothyroidism in patients admitted due to major psychiatric disorders in Montserrat Hospital during the period from March to October 2010. MATERIAL AND METHODS: A descriptive cross-sectional study was conducted on 105 patients admitted to Montserrat Hospital with a primary diagnosis of major psychiatric disorder (major depression, bipolar affective disorder, generalised panic disorder, panic disorder, mixed anxiety-depressive disorder, and schizophrenia) in the aforementioned period...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28724123/assessment-of-insulin-resistance-among-drug-naive-patients-with-first-episode-schizophrenia-in-the-context-of-hormonal-stress-axis-activation
#14
Johann Steiner, Maximus Berger, Paul C Guest, Henrik Dobrowolny, Sabine Westphal, Kolja Schiltz, Zoltán Sarnyai
No abstract text is available yet for this article.
September 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28703738/abnormally-increased-secretion-in-olfactory-neuronal-precursors-from-a-case-of-schizophrenia-is-modulated-by-melatonin-a-pilot-study
#15
Montserrat G Cercós, Tania Galván-Arrieta, Marcela Valdés-Tovar, Héctor Solís-Chagoyán, Jesús Argueta, Gloria Benítez-King, Citlali Trueta
The alterations that underlie the pathophysiology of schizophrenia (SCZ) include the dysregulation of structural and functional properties of neurons. Among these, the secretion of neurotransmitters and hormones, which plays a key role for neuronal communication and development, is altered. Neuronal precursors from the human olfactory epithelium have been recently characterized as a reliable model for studying the etiopathogenesis of neuropsychiatric diseases. Our previous work has shown that melatonin enhances the development of morphological and functional features of cloned olfactory neuronal precursors (ONPs) from a healthy subject...
July 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28702774/do-fsh-lh-ratio-and-gonadal-hormone-levels-predict-clinical-improvement-in-postmenopausal-schizophrenia-women
#16
Alexandre González-Rodríguez, Miquel Bernardo, Rafael Penadés, Bárbara Arias, Victoria Ruiz Cortés, Mary V Seeman, Rosa Catalán
Menopause is a process characterized by a decline in estrogen levels and is therefore a period of biological vulnerability for psychotic relapse in women with schizophrenia. Our goal was to correlate not only gonadal hormone levels but also follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels with improvement in specific clinical symptoms. Thirty-seven acutely ill postmenopausal schizophrenia women with a newly initiated, clinically determined change in antipsychotic medication participated in a 12-week prospective observational outcome study...
July 12, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28681245/an-overview-on-d-amino-acids
#17
REVIEW
Giuseppe Genchi
More than half a century ago researchers thought that D-amino acids had a minor function compared to L-enantiomers in biological processes. Many evidences have shown that D-amino acids are present in high concentration in microorganisms, plants, mammals and humans and fulfil specific biological functions. In the brain of mammals, D-serine (D-Ser) acts as a co-agonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptors, responsible for learning, memory and behaviour. D-Ser metabolism is relevant for disorders associated with an altered function of the NMDA receptor, such as schizophrenia, ischemia, epilepsy and neurodegenerative disorders...
July 5, 2017: Amino Acids
https://www.readbyqxmd.com/read/28674745/selective-enhancement-of-nmda-receptor-mediated-locomotor-hyperactivity-by-male-sex-hormones-in-mice
#18
Maarten van den Buuse, Jac Kee Low, Perrin Kwek, Sally Martin, Andrea Gogos
RATIONALE: Altered glutamate NMDA receptor function is implicated in schizophrenia, and gender differences have been demonstrated in this illness. OBJECTIVES: This study aimed to investigate the interaction of gonadal hormones with NMDA receptor-mediated locomotor hyperactivity and PPI disruption in mice. RESULTS: The effect of 0.25 mg/kg of MK-801 on locomotor activity was greater in male mice than in female mice. Gonadectomy (by surgical castration) significantly reduced MK-801-induced hyperlocomotion in male mice, but no effect of gonadectomy was seen in female mice or on amphetamine-induced locomotor hyperactivity...
July 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28673758/estrogens-and-the-cognitive-symptoms-of-schizophrenia-possible-neuroprotective-mechanisms
#19
REVIEW
Claire McGregor, Alexander Riordan, Janice Thornton
Schizophrenia is a complex neuropsychiatric illness with marked sex differences. Women have later onset and lesser symptoms, which has led to the hypothesis that estrogens are protective in schizophrenia. Cognitive dysfunction is a hallmark of the disease and the symptom most correlated with functional outcome. Here we describe a number of mechanisms by which estrogens may be therapeutic in schizophrenia, with a focus on cognitive symptoms. We review the relationship between estrogens and brain derived neurotrophic factor, neuroinflammation, NMDA receptors, GABA receptors, and luteinizing hormone...
October 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28670953/the-probable-role-of-adrenomedullin-and-nitric-oxide-in-childhood-attention-deficit-hyperactivity-disorder
#20
Börte Gürbüz Özgür, Hatice Aksu, Mustafa Yılmaz, Sevcan Karakoç Demirkaya
BACKGROUND: The role of adrenomedullin hormone, which has been shown to be associated with many psychiatric disorders, in the etiology of ADHD and its relation to disease is not yet known. AIM: In this study, it was aimed to compare plasma adrenomedullin and nitric oxide (NO) levels of newly diagnosed, treatment-naive patients with ADHD with healthy children. METHODS: A total of 45 children with ADHD and 45 healthy children were included. The Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS), a semi-structured interview, was applied to all cases by child and adolescent psychiatrist...
July 2, 2017: Nordic Journal of Psychiatry
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