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Gestational diabetes

Yue Shi, Bin Zhang, Fanbin Kong, Xilian Li
To analyze prenatal ultrasound data for fetal limb deformities in high-risk pregnant women and the risk factors for prenatal limb defects in high-risk pregnant women.This was a retrospective study of high-risk pregnant women at the multidisciplinary consultation center from January 2006 to December 2015. When deformities were definitively diagnosed in the first trimester by ultrasound, patients were recommended to undergo an abortion, and fetal abnormalities were confirmed by pathological examination (both gross anatomic examinations and fetal chromosome and genetic tests)...
July 2018: Medicine (Baltimore)
Zongjian Yang, Hai Phung, Louise Freebairn, Rosalind Sexton, Alexandra Raulli, Paul Kelly
AIMS: Maternal overweight and obesity in pregnancy are known to increase the risk of a range of complications and adverse pregnancy outcomes. This study estimates the population-level contribution of maternal overweight and obesity to adverse pregnancy outcomes. METHODS: Data derived from the Australian Capital Territory (ACT) Maternal and Perinatal Data Collection were analysed. A total of 24 161 women who had a singleton birth in 2009-2015, with maternal weight and height information available, were included...
July 19, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Mitra Kolivand, Mehr Ali Rahimi, Afsaneh Keramat, Mohammad Shariati, Mohammad Hassan Emamian
BACKGROUND: To determine the effect of the new self-care guide package on gestational diabetes mellitus (GDM). METHODS: This randomized clinical trial study was conducted on 152 women with GDM. The intervention group exposed to a self-care guide package and three face to face educational sessions. Control group received routine clinical services including visits by physician and short training about nutrition, blood glucose control, and insulin injections. The primary outcomes were fasting and two hours postprandial blood glucose and self-efficacy measured at the beginning of the study and one month after the end of the intervention...
July 18, 2018: Journal of Diabetes
Rami H Al-Rifai, Faisal Aziz
BACKGROUND: Diabetes mellitus (DM) in women of childbearing age may affect the fetus, thereby accelerating the intergenerational risk of DM. The Middle East and North Africa (MENA) region is experiencing a growing epidemic of DM. We aim to conduct two systematic reviews to summarize the burden of DM in women of childbearing age in the MENA region. In the systematic review 1, we aim to (1) systematically aggregate the evidence on type 2 DM (T2DM) and prediabetes and (2) to synthesize overall estimate on the prevalence of T2DM and overall estimate on the prevalence of prediabetes, in women of childbearing age (15-49 years)...
July 18, 2018: Systematic Reviews
Gloria T Larrabure-Torrealva, Stephanie Martinez, Miguel Angel Luque-Fernandez, Sixto E Sanchez, Pedro A Mascaro, Hugo Ingar, Walter Castillo, Rina Zumaeta, Mirtha Grande, Vicky Motta, Percy Pacora, Bizu Gelaye, Michelle A Williams
BACKGROUND: Gestational diabetes mellitus (GDM) is a global public health concern with potential implications for the health of a mother and her offspring. However, data on the prevalence and risk factors of GDM in Latin America are scarce. The study was designed to estimate the prevalence of GDM and identify maternal risk factors among Peruvian women. METHODS: A cross-sectional study was conducted among 1300 pregnant women attending a prenatal clinic in Lima, Peru...
July 18, 2018: BMC Pregnancy and Childbirth
Mark B Landon, Lisa Mele, Michael W Varner, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George Saade, William Grobman, Sean C Blackwell, J Peter VanDorsten
OBJECTIVE: To determine the association of maternal glycemia with childhood obesity and metabolic dysfunction. STUDY DESIGN: Secondary analysis of follow-up data 5-10 years after a mild gestational diabetes mellitus (GDM) treatment trial. The relationship between maternal oral glucose tolerance testing (OGTT) at 24-31-week gestation and body mass index (BMI), fasting glucose, insulin, and anthropometric measurements (sum of skinfolds, subscapular/triceps ratio, and waist circumference) in the offspring of untreated mild GDM and non-GDM (abnormal 50-g screen/normal OGTT) women was assessed...
July 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Yuanlin Dong, Madhu Chauhan, Ancizar Betancourt, Michael Belfort, Chandra Yallampalli
Context: Impaired maternal lipid metabolism in gestational diabetes mellitus (GDM) has detrimental effects on maternal health and fetal growth. We have previously reported excessive expression of adrenomedullin (ADM) and its receptors in GDM adipose tissues when compared with normal glucose tolerant pregnancies. In this study we determine the mechanisms underlying enhanced ADM and its receptors expressions. Design: Omental adipose tissues (OAT) were collected from women during caesarian sections in term pregnancy with non-overweight (NOW, n=9), overweight (OW, n=8), obese (OBS, n=10), and GDM (n=10)...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Hui Ning, Hong Tao, Zhanping Weng, Xingbo Zhao
The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus".
July 18, 2018: Acta Diabetologica
Ayana Telerant, Galit Levi Dunietz, Ariel Many, Riva Tauman
The prevalence of obstructive sleep apnea (OSA) during pregnancy is rising. OSA during pregnancy has been associated with hypertensive disorders of pregnancy and gestational diabetes. The effect of maternal OSA on the fetus, particularly on fetal growth, is less apparent. Most of the currently available human data is based on non-objective assessment of OSA and includes heterogeneous populations with inadequate control on confounders, such as maternal obesity and pregnancy complications. Using objective tools in non-obese women with uncomplicated pregnancies, we aimed to investigate the association between maternal OSA and fetal growth...
July 17, 2018: Scientific Reports
Megan Jarman, Nonsikelelo Mathe, Fatemeh Ramazani, Mohammadreza Pakseresht, Paula J Robson, Steven T Johnson, Rhonda C Bell
Few studies have explored pre-pregnancy diet and its relationship with pregnancy outcomes. The objectives of this study were to: (1) derive pre-pregnancy dietary patterns for women enrolled in a prospective cohort in the province of Alberta, Canada; (2) describe associations between dietary patterns and socio-demographic characteristics; and (3) describe associations between dietary patterns and pregnancy complications. Upon enrolment into the Alberta Pregnancy Outcomes and Nutrition (APrON) study (median age of gestation, 17 weeks), women ( n = 1545) completed a validated 142-item food frequency questionnaire recording food and beverages consumed "in the 12 months prior to pregnancy"...
July 17, 2018: Nutrients
Ashley N Battarbee, Mark A Clapp, Kim A Boggess, Anjali Kaimal, Carrie Snead, Jay Schulkin, Sofia Aliaga
OBJECTIVE:  The objective of this study was to measure knowledge and practice variation in late preterm steroid use. STUDY DESIGN:  Electronic survey of American College of Obstetricians and Gynecologists (ACOG) members about data supporting the ACOG/Society for Maternal-Fetal Medicine (SMFM) recommendations and practice when caring for women with anticipated late preterm birth (PTB), 340/7 to 366/7 weeks. RESULTS:  Of 352 administered surveys, we obtained 193 completed responses (55%); 82...
July 17, 2018: American Journal of Perinatology
Sushila Arya, Zuber D Mulla, Sanja Kupesic Plavsic
BACKGROUND: The purpose of this study was to evaluate the maternal outcome in women with very advanced maternal age (VAMA) at childbirth (>45 years) compared to advanced maternal age (35-39 and 40-44 years). METHODS: Retrospective cohort study using the Texas Public Use Data File, years 2013-2014. Maternal age was a three-level variable: 35-39 (referent), 40-44, and 45-59 years (VAMA). Adjusted risk ratios (aRRs) for the two older age groups for various obstetrical and nonobstetrical complications were calculated from log-binomial regression models...
July 17, 2018: Journal of Women's Health
Helena E Miettinen, Kristiina Rönö, Saila B Koivusalo, Johan G Eriksson, Helena Gylling
BACKGROUND AND AIMS: Impaired glucose metabolism during pregnancy may associate with changes in fetal cholesterol metabolism. We investigated if gestational diabetes mellitus (GDM) affects newborn cholesterol metabolism as determined by cord blood squalene and non-cholesterol sterols. Furthermore, we examined potential correlations between cord blood and maternal serum non-cholesterol sterols. METHODS: Pregnant women at risk for GDM (BMI>30 kg/m2 ) were enrolled from maternity clinics in Finland...
June 22, 2018: Atherosclerosis
Ahmed A Nassr, Sherif A Shazly, Mari C Trinidad, Sherif A El-Nashar, Amber M Marroquin, Brian C Brost
OBJECTIVES: To evaluate the association of ultrasound measurement of maternal abdominal subcutaneous and pre-peritoneal fat thickness in relation to the subsequent diagnosis of gestational diabetes (GDM), and to assess the association of body fat index (BFI), compared to conventional body mass index (BMI), with respect to the development of some obstetric related complications. STUDY DESIGN: A prospective study included non-diabetic pregnant women who were scheduled for fetal anatomic survey...
July 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
John Punnose, Rajeev Kumar Malhotra, Komal Sukhija, Anu Mathew, Asha Sharma, Naimaa Choudhary
Aims: Presence of bimodality in plasma glucose distribution (BPG) and its relevance for gestational diabetes mellitus (GDM) diagnosis were studied in Asian Indian pregnant women. Methods: Fasting (FPG) and two hour plasma glucose (2-h PG) values of oral glucose tolerance tests performed in 36,530 pregnant women for GDM screening (2006-16 period), were analyzed for BPG. A unimodal normal and a mixture of two normal distributions were fitted to log-transformed FPG and 2-h PG data...
September 2018: Journal of Clinical & Translational Endocrinology
Maisa N Feghali, Christina M Scifres
Diabetes is a common complication of pregnancy, and the prevalence of all types of the disease is increasing worldwide. Diabetes in pregnancy is associated with short term and long term adverse effects for mother and child. The goal of treatment of diabetes in pregnancy is to minimize maternal and fetal adverse events related to hyperglycemia. Treatment options vary by type of diabetes, from a focus on lifestyle modifications in gestational diabetes to continuous glucose monitoring and insulin pumps in pregestational diabetes...
July 16, 2018: BMJ: British Medical Journal
Nora Lee, Mary F Hebert, David J Wagner, Thomas R Easterling, C Jason Liang, Kenneth Rice, Joanne Wang
Metformin, an oral anti-hyperglycemic, is increasingly being prescribed to pregnant women with gestational diabetes. Metformin is a hydrophilic cation and relies on organic cation transporters to move across cell membranes. We previously demonstrated that human and mouse placentas predominantly express organic cation transporter 3 (OCT3), but the impact of this transporter on maternal and fetal disposition of metformin is unknown. Using immunofluorescence colocalization studies in term human placenta, we showed that OCT3 is localized to the basal (fetal-facing) membrane of syncytiotrophoblast cells with no expression on the apical (maternal-facing) membrane...
July 16, 2018: Molecular Pharmacology
Jane Hitti, Laura Sienas, Suzan Walker, Thomas J Benedetti, Thomas Easterling
BACKGROUND: Maternal mortality and severe maternal morbidity are growing public health concerns in the United States. The Centers for Disease Control and Prevention Severe Maternal Morbidity measure provides insight into processes underlying maternal mortality and may highlight modifiable risk factors for adverse maternal health outcomes. OBJECTIVES: The primary objective of this study was to evaluate the association between hypertensive disorders and severe maternal morbidity at a regional perinatal referral center...
July 13, 2018: American Journal of Obstetrics and Gynecology
Kelly F Cummings, Melissa S Helmich, Songthip T Ounpraseuth, Nafisa K Dajani, Everett F Magann
BACKGROUND: Maternal obesity has been associated with an increased risk for an abnormal progression of labour; however, less is known about the length of the third stage of labour and its relation to maternal obesity. OBJECTIVE: To determine if the length of the third stage of labour is increased in extremely obese women and its possible correlation with an increased risk for postpartum hemorrhage. STUDY DESIGN: This was a retrospective cohort study of deliveries from January 2008 to December 2015 at our university hospital...
July 11, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Michael M Aziz, Ankita Kulkarni, Oluwafisayo Tunde-Agbede, Carlos W Benito, Yinka Oyelese
OBJECTIVE: To determine if women who present to the labor and delivery unit at 23 0/7 to 36 6/7 weeks gestation with threatened preterm labor (TPTL) are more likely to be dehydrated than women who present at the same gestational age for other reasons. DESIGN: Retrospective cohort study. SETTING: An academic medical center in the northeastern United States. PARTICIPANTS: All women at preterm gestational ages 23 0/7 to 36 6/7 weeks who presented to the labor and delivery unit for care in 2014...
July 10, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
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