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https://www.readbyqxmd.com/read/29055247/optimization-and-validation-of-reverse-phase-hplc-method-for-qualitative-and-quantitative-assessment-of-polyphenols-in-seaweed
#1
Gaurav Rajauria
A simple reverse phase-high performance liquid chromatography (RP-HPLC) coupled to a diode array detector (DAD) and negative ion electrospray mass spectrometer (ESI-MS) method was developed for simultaneous identification and quantification of phenolic antioxidants in seaweed. The proposed method was validated in terms of linearity, limits of detection (LOD), limits of quantification (LOQ), recovery and intermediate precision. The calibration curves were linear with correlation coefficient ranging from 0.9909 to 0...
October 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055143/pasireotide-for-the-treatment-of-refractory-hypoglycemia-from-malignant-insulinoma
#2
Nicholas S Hendren, Kamaldeep Panach, Timothy J Brown, Lan Peng, Muhammad S Beg, Jonathan Weissler, Sasan Mirfakhraee
Insulinomas are rare, usually solitary benign tumors. The presence of metastases defines malignant insulinomas((1)) . Medical therapy primarily treats symptomatic hypoglycemia, alleviates symptoms, and improves the quality of life in affected individuals. While diazoxide is used as first-line therapy, the incomplete response rate and complications associated with diazoxide provide a role for somatostatin analogues in difficult-to-treat hypoglycemia. This article is protected by copyright. All rights reserved...
October 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29054856/levels-of-%C3%AE-and-%C3%AE-synuclein-regulate-cellular-susceptibility-to-toxicity-from-%C3%AE-synuclein-oligomers
#3
Dafina M Angelova, Hannah B L Jones, David R Brown
α-Synuclein (α-syn) is associated with a range of diseases, including Parkinson disease. In disease, α-syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α-syn results in the formation of stellate toxic oligomers that are highly toxic to cultured neurons. We further investigated the mechanism of toxicity of α-syn oligomers. Cells that overexpress α-syn showed increased susceptibility to the toxicity of the oligomers, while those that overexpressed β-syn showed increased resistance to the toxic oligomers...
October 20, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29054582/characterization-and-functional-analysis-of-a-carboxylesterase-gene-associated-with-chlorpyrifos-resistance-in-nilaparvata-lugens-st%C3%A3-l
#4
Kai Lu, Ying Wang, Xia Chen, Zhichao Zhang, Yue Li, Wenru Li, Qiang Zhou
The widespread and extensive application of insecticides have promoted the development of resistance in the brown planthopper Nilaparvata lugens (Stål), one of the most important rice pests in Asia. To better understand the underlying molecular mechanisms of metabolic resistance to insecticides, a chlorpyrifos-resistant (CR) strain of N. lugens was selected and its possible resistance mechanism was investigated. Synergistic tests using carboxylesterases (CarEs) inhibitor triphenyl phosphate (TPP) decreased the resistance of N...
October 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29054531/the-ammonia-transporter-rhcg-modulates-urinary-acidification-by-interacting-with-the-vacuolar-proton-atpases-in-renal-intercalated-cells
#5
Soline Bourgeois, Lisa Bounoure, Isabelle Mouro-Chanteloup, Yves Colin, Dennis Brown, Carsten A Wagner
Ammonium, stemming from renal ammoniagenesis, is a major urinary proton buffer and is excreted along the collecting duct. This process depends on the concomitant secretion of ammonia by the ammonia channel RhCG and of protons by the vacuolar-type proton-ATPase pump. Thus, urinary ammonium content and urinary acidification are tightly linked. However, mice lacking Rhcg excrete more alkaline urine despite lower urinary ammonium, suggesting an unexpected role of Rhcg in urinary acidification. RhCG and the B1 and B2 proton-ATPase subunits could be co-immunoprecipitated from kidney...
October 17, 2017: Kidney International
https://www.readbyqxmd.com/read/29054308/acc-aats-aha-ase-eacts-hvs-sca-scai-scct-scmr-sts-2017-appropriate-use-criteria-for-the-treatment-of-patients-with-severe-aortic-stenosis-a-report-of-the-american-college-of-cardiology-appropriate-use-criteria-task-force-american-association-for-thoracic-surgery
#6
https://www.readbyqxmd.com/read/29054090/diopside-magnetite-a-novel-nanocomposite-for-hyperthermia-applications
#7
Majid Abdellahi, Ebrahim Karamian, Aliakbar Najafinezhad, Fatemah Ranjabar, Akbar Chami, Amirsalar Khandan
In the present work, the releasing heat, scaffold apatite formation, and magnetic behavior of a novel diopside-magnetite nanocomposite with various contents of magnetite (Fe3O4) were evaluated. The N´eel and Brown relaxations did not have a significant effect on the specific absorption rate (SAR) of the composite samples. Indeed, magnetic saturation, Ms, indicated a crucial effect on the heat release of the samples. The sample with 30wt% magnetite had the highest value of SAR, while the sample with 20wt% magnetite, in the form of scaffold, allowed the high amount of apatite formation on its surface...
October 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29054084/occurrence-and-levels-of-persistent-organic-pollutants-pops-in-farmed-and-wild-marine-fish-from-tanzania-a-pilot-study
#8
Eliezer Brown Mwakalapa, Aviti John Mmochi, Mette Helen Bjorge Müller, Robinson Hammerthon Mdegela, Jan Ludvig Lyche, Anuschka Polder
In 2016, farmed and wild milkfish (Chanos chanos) and mullet (Mugil cephalus) from Tanzania mainland (Mtwara) and Zanzibar islands (Pemba and Unguja) were collected for analyses of persistent organic pollutants (POPs). Fish livers were analysed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs). Muscle tissue was used for analyses of perfluoroalkyl substances (PFASs). The major contaminant was p,p'-DDE. The highest p,p'-DDE concentration was found in wild milkfish from Mtwara (715...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29053983/conceptualizing-trust-in-community-academic-research-partnerships-using-concept-mapping-approach-a-multi-ctsa-study
#9
Gaurav Dave, Leah Frerichs, Jennifer Jones, Mimi Kim, Jennifer Schaal, Stefanie Vassar, Deepthi Varma, Catherine Striley, Corrine Ruktanonchai, Adina Black, Jennifer Hankins, Nakita Lovelady, Crystal Cene, Melissa Green, Tiffany Young, Shristi Tiwari, Ann Cheney, Linda Cottler, Greer Sullivan, Arleen Brown, Jessica Burke, Giselle Corbie-Smith
OBJECTIVES: Collaborations between communities, healthcare practices and academic institutions are a strategy to address health disparities. Trust is critical in the development and maintaining of effective collaborations. The aim of this pilot study was to engage stakeholders in defining determinants of trust in community academic research partnerships and to develop a framework for measuring trust. METHODS: The study was conducted by five collaborating National Institute of Health' Clinical and Translational Sciences Awardees...
October 12, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29053967/friends-in-low-places-intestinal-commensals-limit-colitis-through-molecular-mimicry
#10
D Garrett Brown, June L Round
Inflammatory bowel disease is thought to arise from inappropriate inflammation to gut bacteria, yet mechanisms preventing these responses remain elusive. In this issue of Cell, Nanjundappa et al. report that Bacteroides share an epitope with a pancreas-specific peptide that induces protective CD8+ T cells, identifying molecular mimicry as a mechanism to enforce tolerance in the gut.
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053922/progress-in-top-down-control-of-bottom-up-assembly
#11
Benjamin P Isaacoff, Keith A Brown
This is an Editorial.
October 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/29053875/current-state-of-the-surgical-treatment-of-terminal-neuromas
#12
Graham C Ives, Theodore A Kung, Bao Tram Nghiem, Daniel C Ursu, David L Brown, Paul S Cederna, Stephen W P Kemp
Painful terminal neuromas resulting from nerve injury following amputation are common. However, there is currently no universally accepted gold standard of treatment for this condition. A comprehensive literature review is presented on the treatment of terminal neuromas. Four categories of terminal neuroma surgical procedures are assessed: epineurial closure; nerve transposition with implantation; neurorrhaphy, and alternate target reinnervation. Significant patient and case studies are highlighted in each section, focusing on surgical technique and patient outcome metrics...
October 19, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29053865/beta-burst-dynamics-in-parkinson-s-disease-off-and-on-dopaminergic-medication
#13
Gerd Tinkhauser, Alek Pogosyan, Huiling Tan, Damian M Herz, Andrea A Kühn, Peter Brown
Exaggerated basal ganglia beta activity (13-35 Hz) is commonly found in patients with Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms. Importantly, beta activity is not continuously elevated, but fluctuates to give beta bursts. The percentage number of longer beta bursts in a given interval is positively correlated with clinical impairment in Parkinson's disease patients. Here we determine whether the characteristics of beta bursts are dependent on dopaminergic state...
October 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053860/clinicopathological-correlations-in-behavioural-variant-frontotemporal-dementia
#14
David C Perry, Jesse A Brown, Katherine L Possin, Samir Datta, Andrew Trujillo, Anneliese Radke, Anna Karydas, John Kornak, Ana C Sias, Gil D Rabinovici, Maria Luisa Gorno-Tempini, Adam L Boxer, Mary De May, Katherine P Rankin, Virginia E Sturm, Suzee E Lee, Brandy R Matthews, Aimee W Kao, Keith A Vossel, Maria Carmela Tartaglia, Zachary A Miller, Sang Won Seo, Manu Sidhu, Stephanie E Gaus, Alissa L Nana, Jose Norberto S Vargas, Ji-Hye L Hwang, Rik Ossenkoppele, Alainna B Brown, Eric J Huang, Giovanni Coppola, Howard J Rosen, Daniel Geschwind, John Q Trojanowski, Lea T Grinberg, Joel H Kramer, Bruce L Miller, William W Seeley
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the success of disease-modifying therapies. We sought to improve pathological prediction by exploring clinicopathological correlations in a large bvFTD cohort. Among 438 patients in whom bvFTD was either the top or an alternative possible clinical diagnosis, 117 had available autopsy data, including 98 with a primary pathological diagnosis of frontotemporal lobar degeneration (FTLD), 15 with Alzheimer's disease, and four with amyotrophic lateral sclerosis who lacked neurodegenerative disease-related pathology outside of the motor system...
October 6, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053852/genome-wide-scan-and-analysis-of-positive-selective-signatures-in-dwarf-brown-egg-layers-and-silky-fowl-chickens
#15
Mengmeng Zhang, Liu Yang, Zhencheng Su, Muzhen Zhu, Wenting Li, Keliang Wu, Xuemei Deng
Chinese domestic chickens have been routinely subjected to artificial selection for the production of meats and eggs. Selection results in distinctive signatures in the genome that can reveal the genes underlying phenotypes of interest to breeders. In this study, we used the Chicken60K SNP chip to analyze DNA from Dwarf Brown-egg Layers (DB, n = 203) and Silky Fowls (SF, n = 181) and then examined the relative extended haplotype homozygosity (REHH) and fixation index (FST) to detect selection signatures. Since population structure analysis showed that SF was stratified into 2 subpopulations (SF1 and SF2), we removed the 20 SF1 chickens, and the remaining individuals (DB and SF2) were scanned for genome-wide selection signatures...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053833/clinical-pathological-and-functional-characterization-of-riboflavin-responsive-neuropathy
#16
Andreea Manole, Zane Jaunmuktane, Iain Hargreaves, Marthe H R Ludtmann, Vincenzo Salpietro, Oscar D Bello, Simon Pope, Amelie Pandraud, Alejandro Horga, Renata S Scalco, Abi Li, Balasubramaniem Ashokkumar, Charles M Lourenço, Simon Heales, Rita Horvath, Patrick F Chinnery, Camilo Toro, Andrew B Singleton, Thomas S Jacques, Andrey Y Abramov, Francesco Muntoni, Michael G Hanna, Mary M Reilly, Tamas Revesz, Dimitri M Kullmann, James E C Jepson, Henry Houlden
Brown-Vialetto-Van Laere syndrome represents a phenotypic spectrum of motor, sensory, and cranial nerve neuropathy, often with ataxia, optic atrophy and respiratory problems leading to ventilator-dependence. Loss-of-function mutations in two riboflavin transporter genes, SLC52A2 and SLC52A3, have recently been linked to Brown-Vialetto-Van Laere syndrome. However, the genetic frequency, neuropathology and downstream consequences of riboflavin transporter mutations are unclear. By screening a large cohort of 132 patients with early-onset severe sensory, motor and cranial nerve neuropathy we confirmed the strong genetic link between riboflavin transporter mutations and Brown-Vialetto-Van Laere syndrome, identifying 22 pathogenic mutations in SLC52A2 and SLC52A3, 14 of which were novel...
September 26, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053542/biomechanical-comparison-of-intrapelvic-and-extrapelvic-fixation-for-acetabular-fractures-involving-the-quadrilateral-plate
#17
Gregory J Gillispie, Sharon N Babcock, Kyle P McNamara, Michaela E Dimoff, Arun Aneja, Philip J Brown, Eben A Carroll
OBJECTIVES: Elderly patients represent the fastest growing and most difficult to treat population sustaining acetabular fractures. When treated surgically, isolated extrapelvic or combined intrapelvic-extrapelvic constructs may be used. No biomechanical or clinical study has compared the merits of these 2 techniques in cadaveric models. This research aims to biomechanically quantify the additional benefit of intrapelvic fixation to a standard extrapelvic fixation construct. METHODS: Ten cadaveric pelves underwent standardized anterior column and quadrilateral plate fracture creation...
November 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29053533/use-of-a-single-anatomic-donor-site-for-harvesting-a-full-thickness-skin-graft-and-a-free-cartilage-graft-for-nasal-defects
#18
Jessica Olander, Melanie Wong, Mariah Brown
No abstract text is available yet for this article.
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29053484/the-effect-of-low-frequency-repetitive-transcranial-magnetic-stimulation-at-orbitofrontal-cortex-in-the-treatment-of-patients-with-medication-refractory-obsessive-compulsive-disorder-a-retrospective-open-study
#19
Saurabh Kumar, Swarndeep Singh, Rakesh Kumar Chadda, Rohit Verma, Nand Kumar
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a chronic debilitating psychiatric disorder, with significant proportion of patients failing to respond with current first-line treatments. The present study assesses the safety and effectiveness of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) over left-orbitofrontal cortex (Lt-OFC) as a potential augmentation strategy in treatment of patients with medication-refractory OCD in real-world clinical setting. The present report also aims to examine the factors affecting response to rTMS and the durability of effects produced by rTMS over 1 month of follow-up period...
October 19, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29053435/temporal-occurrence-and-niche-preferences-of-phytophthora-species-causing-brown-rot-of-citrus-in-the-central-valley-of-california
#20
W Hao, Timothy D Miles, Frank N Martin, Greg Browne, Helga Forster, James E Adaskaveg
Brown rot of citrus fruits is caused by several species of Phytophthora and is currently of serious concern for the California citrus industry. Two species, P. syringae and P. hibernalis, are quarantine pathogens in China, a major export market for California citrus. To maintain trade and estimate the risk of exporting a quarantine pathogen, the distribution and frequency of Phytophthora species causing brown rot of oranges in major growing areas of California was investigated. Symptomatic fruit were collected from navel (winter to late spring) and Valencia (late spring to summer) orange orchards from 2013 to 2015...
October 20, 2017: Phytopathology
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