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https://www.readbyqxmd.com/read/29240740/characteristics-of-and-differences-between-pasifika-women-and-new-zealand-european-women-diagnosed-with-breast-cancer-in-new-zealand
#1
Charis Brown, Chunhuan Lao, Ross Lawrenson, Sandar Tin Tin, Michelle Schaaf, Jacquie Kidd, Anne Allan-Moetaua, Josephine Herman, Reena Raamsroop, Ian Campbell, Mark Elwood
AIM: Breast cancer in New Zealand-based Pasifika women is a significant issue. Although Pasifika women have a lower incidence of breast cancer compared to New Zealand European women, they have higher breast cancer mortality and lower five-year survival. The aim of this study was to describe the characteristics and tumour biology of Pasifika women and to compare New Zealand European women to identify what factors impact on early (Stage 1 and 2) vs advanced stage (Stage 3 and 4) at diagnosis...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240546/the-psychosocial-themes-of-children-with-a-congenital-heart-defect
#2
Ronél van der Watt, Carina Pheiffer, Stephen Brown
Children living with a congenital heart defect (CHD) carry the burden of a condition affecting their biological, psychological, and social functioning. Even though the physical heartbeats of these children might be inaudible and defective, their intra- and inter-personal 'stories in sound' need to be heard and understood. The aim of this research study was to explore these 'stories in sound' in children diagnosed with CHD. A qualitative, exploratory, descriptive study using thematic analysis was conducted. Semi-structured interviews were conducted with six boys and three girls between the ages of eight and fourteen years, who were diagnosed with CHD...
November 2017: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29240508/medical-complications-of-bulimia-nervosa
#3
Philip S Mehler, Anne O'Melia, Carrie Brown, Dennis Gibson, Jeff Hollis, Patricia Westmoreland
Bulimia nervosa is a psychiatric disorder with many different medical sequelae. This article reviews the principal medical complications associated with bulimia nervosa, and emphasizes the importance of a timely approach to diagnosis and management.
December 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29240228/chromatographic-methods-in-hiv-medicine-application-to-therapeutic-drug-monitoring
#4
REVIEW
Timothy L Archibald, Derek E Murrell, Stacy D Brown
HIV antiretroviral therapy spans several different drug classes, meant to combat various aspects of viral infection and replication. Many authors have argued the benefits of therapeutic drug monitoring (TDM) for the HIV-patient including compliance assurance and assessment of appropriate drug concentrations; however, the array of drug chemistries and combinations makes TDM an arduous task. HPLC-UV and LC-MS/MS are both frequent instruments for the quantification of HIV drugs in biological matrices with investigators striving to balance sensitivity and affordability...
December 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29239992/comparison-of-resistance-based-walking-cardiorespiratory-test-to-the-bruce-protocol
#5
Christopher P Hurt, Marcas Bamman, Avantika Naidu, David A Brown
Cardiorespiratory fitness is assessed through graded exercise tests that determine the maximum amount of sustained mechanical work that an individual can perform while also providing health and fitness related information. This manuscript describes a novel method to perform graded exercise tests that uses posteriorly directed resistive forces. The purpose of this investigation is to validate a novel resistance based test in comparison to a traditional speed and incline based test in a cohort of non-impaired individuals...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239792/francisella-tularensis-and-other-bacteria-in-hares-and-ticks-in-north-rhine-westphalia-germany
#6
Herbert Tomaso, Peter Otto, Martin Peters, Jochen Süss, Axel Karger, Heinz Schamoni, Eric Zuchantke, Helmut Hotzel
Tularemia is a zoonotic disease caused by the bacterium Francisella tularensis. The disease can be transmitted to humans through contact with infected animals such as the European brown hare (Lepus europaeus) and ticks as vectors. The aim of this study was to isolate F. tularensis from ticks and hares in North Rhine-Westphalia using cysteine heart agar to determine their genetic relatedness and to identify other bacteria that grow on this medium. 848 European brown hares and 1556 questing ticks (all Ixodes ricinus) from forests were tested using cultivation and MALDI-TOF mass spectrometry or partial 16S rRNA gene sequencing...
November 21, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29239763/the-tourniquet-gap-a-pilot-study-of-the-intuitive-placement-of-three-tourniquet-types-by-laypersons
#7
Elliot M Ross, Julian G Mapp, Theodore T Redman, Derek J Brown, Chetan U Kharod, David A Wampler
BACKGROUND: The "Stop the Bleed" campaign in the United States advocates for nonmedical personnel to be trained in basic hemorrhage control and that "bleeding control kits" be available in high-risk areas. However, it is not clear which tourniquets are most effective in the hands of laypersons. OBJECTIVES: The objective of this pilot study was to determine which tourniquet type was the most intuitive for a layperson to apply correctly. METHODS: This project is a randomized study derived from a "Stop the Bleed" education initiative conducted between September 2016 and March 2017...
November 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29239646/a-comparison-of-personality-in-the-common-and-bolivian-squirrel-monkey-saimiri-sciureus-and-saimiri-boliviensis
#8
Vanessa A D Wilson, Miho Inoue-Murayama, Alexander Weiss
Personality has been studied in all of the great apes, many Old World monkey species, but only a handful of New World monkey species. Because understanding the personalities of New World monkeys is crucial to understanding personality evolution in primates, we used the Hominoid Personality Questionnaire to assess personality in 55 common squirrel monkeys (Saimiri sciureus) and 40 Bolivian squirrel monkeys (Saimiri boliviensis). We found 4 personality components in each species, and labeled them Openness, Neuroticism, Assertiveness, and Agreeableness...
December 14, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/29239516/engineering-contactless-particle-particle-interactions-in-active-microswimmers
#9
Amir Nourhani, Daniel Brown, Nicholas Pletzer, John G Gibbs
Artificial self-propelled colloidal particles have recently served as effective building blocks for investigating many dynamic behaviors exhibited by nonequilibrium systems. However, most studies have relied upon excluded volume interactions between the active particles. Experimental systems in which the mobile entities interact over long distances in a well-defined and controllable manner are valuable so that new modes of multiparticle dynamics can be studied systematically in the laboratory. Here, a system of self-propelled microscale Janus particles is engineered to have contactless particle-particle interactions that lead to long-range attraction, short-range repulsion, and mutual alignment between adjacent swimmers...
December 2017: Advanced Materials
https://www.readbyqxmd.com/read/29239234/adoption-of-in-vitro-systems-and-zebrafish-embryos-as-alternative-models-for-reducing-rodent-use-in-assessments-of-immunological-and-oxidative-stress-responses-to-nanomaterials
#10
Helinor J Johnston, Rachel Verdon, Suzanne Gillies, David M Brown, Teresa F Fernandes, Theodore B Henry, Adriano G Rossi, Lang Tran, Carl Tucker, Charles R Tyler, Vicki Stone
Assessing the safety of engineered nanomaterials (NMs) is paramount to the responsible and sustainable development of nanotechnology, which provides huge societal benefits. Currently, there is no evidence that engineered NMs cause detrimental health effects in humans. However, investigation of NM toxicity using in vivo, in vitro, in chemico, and in silico models has demonstrated that some NMs stimulate oxidative stress and inflammation, which may lead to adverse health effects. Accordingly, investigation of these responses currently dominates NM safety assessments...
December 14, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29239133/simplicity-at-the-cost-of-predictive-accuracy-in-diffuse-large-b-cell-lymphoma-a-critical-assessment-of-the-r-ipi-ipi-and-nccn-ipi
#11
Jorne Biccler, Sandra Eloranta, Peter de Nully Brown, Henrik Frederiksen, Mats Jerkeman, Karin E Smedby, Martin Bøgsted, Tarec C El-Galaly
The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI) to a Cox proportional hazards (CPH) model using the same covariates in nondichotomized form. All models were tested in 4863 newly diagnosed DLBCL patients from population-based Nordic registers...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29239038/gastroenteropancreatic-neuroendocrine-neoplasms-selected-pathology-review-and-molecular-updates
#12
REVIEW
Siaw M Chai, Ian S Brown, M Priyanthi Kumarasinghe
Gastroenteropancreatic (GEP) neuroendocrine neoplasms can be broadly separated into well- and poorly differentiated categories. Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology of these differences is multifactorial. Site of origin, mucosal milieu and hereditary influences are some of the currently known factors. Given these differences, staging and grading systems continue to evolve, and the most recent World Health Organization classification of pancreatic neuroendocrine neoplasms reflects this by introducing a grade 3 neuroendocrine tumour category for morphologically well-differentiated tumours with an elevated Ki-67 proliferation index and/or mitotic count...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238866/validation-of-goose-liver-fat-measurement-by-qct-and-cse-mri-with-biochemical-extraction-and-pathology-as-reference
#13
Li Xu, Yangyang Duanmu, Glen M Blake, Chenxin Zhang, Yong Zhang, Keenan Brown, Xiaoqi Wang, Peng Wang, Xingang Zhou, Manling Zhang, Chao Wang, Zhe Guo, Giuseppe Guglielmi, Xiaoguang Cheng
OBJECTIVES: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. METHODS: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical measurement and histology...
December 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29238848/biology-of-bone-sarcomas-and-new-therapeutic-developments
#14
REVIEW
Hannah K Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis...
December 13, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29238745/dye-based-mito-thermometry-and-its-application-in-thermogenesis-of-brown-adipocytes
#15
Tao-Rong Xie, Chun-Feng Liu, Jian-Sheng Kang
Mitochondrion is the main intracellular site for thermogenesis and attractive energy expenditure targeting for obesity therapy. Here, we develop a method of mitochondrial thermometry based on Rhodamine B methyl ester, which equilibrates as a thermosensitive mixture of nonfluorescent and fluorescent resonance forms. Using this approach, we are able to demonstrate that the efficacy of norepinephrine-induced thermogenesis is low, and measure the maximum transient rate of temperature increase in brown adipocytes...
2017: Biophysics Reports
https://www.readbyqxmd.com/read/29238578/bone-eating-kidney-disease
#16
Abhilash Koratala, Muhannad Leghrouz, Amir Kazory
In the current era of early detection of chronic kidney disease and efficient therapeutic options for management of its complications, skeletal manifestations of renal hyperparathyroidism are increasingly rare. A 31-year-old female patient presented for evaluation of severe pain in the left forearm, right hand, right knee, right hip, and lower back following a fall sustained 3 days prior to presentation. She had a history of end-stage renal disease and received maintenance hemodialysis. Review of the medical records revealed that she had poor compliance with her diet, medications, and dialysis treatments...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29238562/colorful-seashells-identification-of-haem-pathway-genes-associated-with-the-synthesis-of-porphyrin-shell-color-in-marine-snails
#17
Suzanne T Williams, Anne E Lockyer, Patricia Dyal, Tomoyuki Nakano, Celia K C Churchill, Daniel I Speiser
Very little is known about the evolution of molluskan shell pigments, although Mollusca is a highly diverse, species rich, and ecologically important group of animals comprised of many brightly colored taxa. The marine snail genus Clanculus was chosen as an exceptional model for studying the evolution of shell color, first, because in Clanculus margaritarius and Clanculus pharaonius both shell and foot share similar colors and patterns; and second, because recent studies have identified the pigments, trochopuniceus (pink-red), and trochoxouthos (yellow-brown), both comprised of uroporphyrin I and uroporphyrin III, in both shell and colored foot tissue of these species...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238313/differential-neural-processing-of-social-exclusion-and-inclusion-in-adolescents-with-non-suicidal-self-injury-and-young-adults-with-borderline-personality-disorder
#18
Rebecca C Brown, Paul L Plener, Georg Groen, Dominik Neff, Martina Bonenberger, Birgit Abler
Introduction: Non-suicidal self-injury (NSSI) is a symptom of borderline personality disorder (BPD). However, NSSI often occurs independently of BPD. Altered neural processing of social exclusion has been shown in adolescents with NSSI and adults with BPD with additional alterations during social inclusion in BPD patients. Aims of this study were to investigate differences in neural processing of social inclusion and exclusion situations between adolescents with NSSI and young adults with BPD and NSSI...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29237913/the-clinical-significance-of-secreted-protein-acidic-and-rich-in-cysteine-expression-in-breast-cancer-tissue-and-its-association-with-prognosis
#19
Wei Guo, Mingliang Zhang, Yong Chen, Suyang Guo
OBJECTIVE: The aim of this study was to evaluate the secreted protein acidic and rich in cysteine (SPARC) expression in breast cancer tissue and its association with patients' clinical pathology characteristics and prognosis. MATERIALS AND METHODS: Eight-eight cases with confirmed diagnosis of breast cancer who received operation from January 2010 to February 2016 were included in this study. The SPARC expression in cancer tissue was examined by immunohistochemical method...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237818/mps1-promotes-chromosome-meiotic-chromosome-bi-orientation-through-dam1
#20
Régis E Meyer, Jamin Brown, Lindsay Beck, Dean S Dawson
In budding yeast meiosis, homologous chromosomes become linked by chiasmata and then move back and forth on the spindle until they are bi-oriented - with the kinetochores of the partners attached to microtubules from opposite spindle poles. Certain mutations in the conserved kinase, Mps1, result in catastrophic meiotic segregation errors but mild mitotic defects. We tested whether Dam1, a known substrate of Mps1 was necessary for its critical meiotic role. We found that kinetochore-microtubule attachments are established even when Dam1 is not phosphorylated by Mps1, but that Mps1 phosphorylation of Dam1 sustains those connections...
December 13, 2017: Molecular Biology of the Cell
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