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Majid Maybody, David C Madoff, Raymond H Thornton, Steven A Morales, Chaya S Moskowitz, Meier Hsu, Lynn A Brody, Karen T Brown, Anne M Covey
PURPOSE: To report 3 new cases of catheter-directed endovascular application of thrombin and explore trends by analysis of published case series. MATERIALS AND METHODS: Institutional Review Board approved this retrospective study. All cases of non-tumoral arterial embolization performed from January 2003 to January 2015 at our institution were retrospectively reviewed. Thrombin was used in 7 of 589 cases. In 3 cases intra arterial thrombin was injected via catheter to treat active hemorrhage...
November 29, 2016: Clinical Imaging
Nisha Shabnam, P Sharmila, Hyunook Kim, P Pardha-Saradhi
The unique potential of chloroplasts/thylakoids to harness light energy to transport electrons from H2O to various entities was exploited for reduction of Ag+ to generate nanoparticles (NPs). Spinach thylakoids/chloroplasts turned AgNO3 solutions brown in light, but not in dark. Besides showing Ag-NPs specific surface plasmon resonance band, these brown solutions showed presence of 5-30 nm crystalline NPs composed of Ag. Powder X-ray diffraction (PXRD) analysis revealed that Ag-NPs were biphasic composed of face-centered cubic Ag0 and cubic Ag2O...
2016: PloS One
Elizabeth M Brown, Lisa R McTaggart, Sean X Zhang, Donald E Low, David A Stevens, Susan E Richardson
[This corrects the article DOI: 10.1371/journal.pone.0059237.].
2016: PloS One
Liping Luo, Meilian Liu
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity...
December 2016: Journal of Endocrinology
Manuvesh Sangwan, Lei Zhu
2-Nitrophenol is an important component of "brown carbon" in the atmosphere. Photolysis is its dominant gas phase removal process. We have determined the gas phase absorption cross sections of 2-nitrophenol in the 295-400 nm region by using cavity ring-down spectroscopy. 2-Nitrophenol exhibits a broad absorption band over the wavelength region studied, with the peak absorption located at 345 nm. Absorption cross section values range between (2.86 ± 0.18) × 10(-18) and (2.63 ± 0.31) × 10(-20) cm(2)/molecule over the 295-400 nm range...
December 9, 2016: Journal of Physical Chemistry. A
Xiuquan Zhou, Brandon Wilfong, Hector Vivanco, Johnpierre Paglione, Craig M Brown, Efrain E Rodriguez
We present a general strategy to synthesize metastable layered materials via topochemical deintercalation of thermodynamically stable phases. Through kinetic control of the deintercalation reaction, we have prepared two hypothesized metastable compounds, CoSe and CoS, with the anti-PbO type structure from the starting compounds KCo2Se2 and KCo2S2, respectively. Thermal stability, crystal structure from X-ray and neutron diffraction, magnetic susceptibility, magnetization, and electrical resistivity are studied for these new layered chalcogenides; both CoSe and CoS are found to be weak itinerant ferromagnets with Curie temperatures close to 10 K...
December 9, 2016: Journal of the American Chemical Society
Duenpen Unjaroen, Marcel Swart, Wesley R Browne
Phenolato moieties impart redox flexibility to metal complexes due their accessible (oxidative) redox chemistry and have been proposed as functional ligand moieties in redox non-innocent ligand based transition metal catalysis. Here, the electro- and spectroelectrochemistry of phenolato based μ-oxo-diiron(III) complexes [(L(1))Fe(μ-O)Fe(L(1))](2+) (1) and [(L(2))Fe(μ-O)Fe(L(2))](2+) (2), where L(1) = 2-(((di(pyridin-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)phenol and L(2) = 3,5-di-tert-butyl-2-(((di(pyridin-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)phenol, is described...
December 9, 2016: Inorganic Chemistry
Weida Gong, Jamie Browne, Nathan Hall, David Schruth, Hans Paerl, Adrian Marchetti
In coastal waters worldwide, an increase in frequency and intensity of algal blooms has been attributed to eutrophication, with further increases predicted because of climate change. Yet, the cellular-level changes that occur in blooming algae remain largely unknown. Comparative metatranscriptomics was used to investigate the underlying molecular mechanisms associated with a dinoflagellate bloom in a eutrophied estuary. Here we show that under bloom conditions, there is increased expression of metabolic pathways indicative of rapidly growing cells, including energy production, carbon metabolism, transporters and synthesis of cellular membrane components...
December 9, 2016: ISME Journal
(no author information available yet)
This article has been prepared by Helen Roberts and colleagues from Defra's International Disease Monitoring Team with Jane Clark, Richard Irvine and Ian Brown of the APHA.
December 3, 2016: Veterinary Record
Steven A Bloomer, Alicia K Olivier, Ottar M Bergmann, M Meleah Mathahs, Kimberly A Broadhurst, Hasan Hicsasmaz, Kyle E Brown
: Nonalcoholic steatohepatitis is a common liver disease that is often accompanied by dysregulated iron metabolism. The aim of the study was to test the hypothesis that aberrant iron metabolism in nonalcoholic steatohepatitis is modulated by genetic susceptibility to inflammation and oxidative stress. Hepatic histology and iron content were assessed in 3 inbred strains of mice (C57BL/6, BALB/c, and C3H/HeJ) fed an atherogenic diet (AD). Hepatic expression of genes relevant to iron metabolism, inflammation, and oxidative stress were quantitated by real-time reverse transcription-polymerase chain reaction...
December 2016: Cell Biochemistry and Function
Hiroki Asano, Ryosuke Kida, Kengo Muto, Takayuki Y Nara, Ken Kato, Osamu Hashimoto, Teruo Kawada, Tohru Matsui, Masayuki Funaba
Brown adipocytes dissipate chemical energy in the form of heat through the expression of mitochondrial uncoupling protein 1 (Ucp1); Ucp1 expression is further upregulated by the stimulation of β-adrenergic receptors in brown adipocytes. An increase in energy expenditure by activated brown adipocytes potentially contributes to the prevention of or therapeutics for obesity. The present study examined the effects of milk by-products, buttermilk and butter oil, on brown adipogenesis and the function of brown adipocytes...
December 2016: Cell Biochemistry and Function
N Haskins, A Mumo, P H Brown, M Tuchman, H Morizono, L Caldovic
N-acetylglutamate synthase (NAGS; E.C. catalyzes the formation of N-acetylglutamate (NAG) from acetyl coenzyme A and glutamate. In microorganisms and plants, NAG is the first intermediate of the L-arginine biosynthesis; in animals, NAG is an allosteric activator of carbamylphosphate synthetase I and III. In some bacteria bifunctional N-acetylglutamate synthase-kinase (NAGS-K) catalyzes the first two steps of L-arginine biosynthesis. L-arginine inhibits NAGS in bacteria, fungi, and plants and activates NAGS in mammals...
December 9, 2016: Scientific Reports
Sam Stephenson, P D Brown
INTRODUCTION: Uropathogenic Escherichia coli (UPEC) rely on the correlation of virulence expression with antimicrobial resistance to persist and cause severe urinary tract infections (UTIs). OBJECTIVES: We assessed the virulence pattern and prevalence among UPEC strains susceptible and resistant to multiple antimicrobial classes. METHODS: A total of 174 non-duplicate UPEC strains from patients with clinically significant UTIs were analysed for susceptibility to aminoglycoside, antifolate, cephalosporin, nitrofuran and quinolone antibiotics for the production of extended-spectrum β-lactamases and for the presence of six virulence determinants encoding adhesins (afimbrial, Type 1 fimbriae, P and S-fimbriae) and toxins (cytotoxic necrotising factor and haemolysin)...
October 2016: Indian Journal of Medical Microbiology
Nathan R James, Alan Brown, Yuliya Gordiyenko, V Ramakrishnan
Ribosomes stall when they encounter the end of mRNA without an in-frame stop codon. In bacteria, these nonstop complexes can be rescued by alternative ribosome-rescue factor A (ArfA). Here, using electron cryomicroscopy, we have determined structures of ArfA bound to the ribosome with 3'-truncated mRNA to resolutions from 3.0 to 3.4 Å. ArfA binds within the ribosomal mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting release factor 2 (RF2), initially in a compact pre-accommodated state...
December 1, 2016: Science
Paula Camacho-Basallo, Rosa-María Yáñez-Vico, Enrique Solano-Reina, Alejandro Iglesias-Linares
OBJECTIVES: The need for accurate techniques of estimating age has sharply increased in line with the rise in illegal migration and the political, economic and socio-demographic problems that this poses in developed countries today. The methods routinely employed for determining chronological age are mainly based on determining skeletal maturation using radiological techniques. The objective of this study was to correlate five different methods for assessing skeletal maturation. MATERIALS AND METHODS: 606 radiographs of growing patients were analyzed, and each patient was classified according to two cervical vertebral-based methods, two hand-wrist-based methods and one tooth-based method...
December 9, 2016: Acta Odontologica Scandinavica
Yi Chen, Joop L M Hermens, Michiel T O Jonker, Jon A Arnot, James M Armitage, Trevor Brown, John W Nichols, Kellie A Fay, Steven T J Droge
Greater knowledge of biotransformation rates for ionizable organic compounds (IOCs) in fish is required to properly assess the bioaccumulation potential of many environmentally relevant contaminants. In this study, we measured in vitro hepatic clearance rates for 50 IOCs using a pooled batch of liver S9 fractions isolated from rainbow trout (Oncorhynchus mykiss). The IOCs included four types of strongly ionized acids (carboxylates, phenolates, sulfonates, and sulfates), three types of strongly ionized bases (primary, secondary, tertiary amines), and a pair of quaternary ammonium compounds (QACs)...
December 6, 2016: Environmental Science & Technology
Alissa Cordner, Lauren Richter, Phil Brown
Concern about the toxicity and exposure of per- and polyfluoroalkyl substances (PFASs) is growing among scientists, regulators, and residents of contaminated communities. In 2016, the United States Food and Drug Administration (FDA) removed three food contact substances (FCSs) containing perfluorinated chemicals from the list of approved FCSs due to concerns regarding chemical safety. To investigate the significance and limitations of the FDA's regulatory action for environmental health research, advocacy, and regulation, we conducted a media analysis and qualitative interviews with a range of involved stakeholders...
December 6, 2016: Environmental Science & Technology
Tak H Kim, Alan R White, Joseph P Sirdaarta, Wenyu Ji, Ian E Cock, James St John, Sue E Boyd, Christopher L Brown, Qin Li
We report carbon nanodots that can be utilized as effective color converting phosphors for the production of white light-emitting diodes (LEDs). Blue-excitable and yellow-emitting carbon nanodots, functionalized with 3-(imidazolidin-2-on-1-yl)propylmethyldimethoxysilane (IPMDS)-derived moieties (IS-CDs), are synthesized by a novel one-pot reaction in which the products from the initial reaction occurring between urea and 3-(2-aminoethylamino)propylmethyl-dimethoxysilane (AEPMDS) are further treated with citric acid...
December 7, 2016: ACS Applied Materials & Interfaces
Yujie Ke, Igal Balin, Ning Wang, Qi Lu, Alfred Iing Yoong Tok, Timothy J White, Shlomo Magdassi, Ibrahim Abdulhalim, Yi Long
Two-dimensional (2D) photonic structures, widely used for generating photonic band gaps (PBG) in a variety of materials, are for the first time integrated with the temperature-dependent phase change of vanadium dioxide (VO2). VO2 possesses thermochromic properties, whose potential remains unrealized due to an undesirable yellow-brown color. Here, a SiO2/VO2 core/shell 2D photonic crystal is demonstrated to exhibit static visible light tunability and dynamic near-infrared (NIR) modulation. Three-dimensional (3D) finite difference time domain (FDTD) simulations predict that the transmittance can be tuned across the visible spectrum, while maintaining good solar regulation efficiency (ΔTsol = 11...
December 7, 2016: ACS Applied Materials & Interfaces
Heajin Lee, Wenjun Liu, Adrienne S Brown, Ralf Landgraf, James N Wilson
The human epidermal growth factor receptor, EGFR/ERBB/HER, family of receptor tyrosine kinases is central to many signaling pathways and a validated chemotherapy target in multiple cancers. While EGFR/ERBB-targeted therapies, including monoclonal antibodies, e.g., trastuzumab, and small molecule kinase inhibitors, such as lapatinib, have been developed, rapid identification and classification of cancer cells is key to identifying the best treatment regime. We report ERBB2 (also HER2) targeting kinase probes that exhibit a "turn-on" emission response upon binding...
December 6, 2016: Analytical Chemistry
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