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https://www.readbyqxmd.com/read/29442380/marketing-medicines-charting-the-rise-of-modern-therapeutics-through-a-systematic-review-of-adverts-in-uk-medical-journals-1950-1980
#1
REVIEW
A Richard Green, Peter M Haddad, Jeffrey K Aronson
AIMS: To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS: We systematically reviewed advertisements promoting drugs for specific therapeutic areas, namely central nervous system disorders (anxiety and sleep disorders, depression, psychoses, and Parkinson's disease), respiratory disorders, cardiovascular disorders, and gastrointestinal disorders...
February 14, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29437689/antibiotics-for-uncomplicated-skin-abscesses-systematic-review-and-network-meta-analysis
#2
Wen Wang, Wenwen Chen, Yanmei Liu, Reed Alexander C Siemieniuk, Ling Li, Juan Pablo Díaz Martínez, Gordon H Guyatt, Xin Sun
OBJECTIVE: To assess the impact of adjunctive antibiotic therapy on uncomplicated skin abscesses. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medline, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov. STUDY SELECTION: A BMJ Rapid Recommendation panel provided input on design, important outcomes and the interpretation of the results. Eligible randomised controlled trials (RCTs) included a comparison of antibiotics against no antibiotics or a comparison of different antibiotics in patients with uncomplicated skin abscesses, and reported outcomes prespecified by the linked guideline panel...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29436489/-cryptogenic-drop-attacks-revisited-evidence-of-overlap-with-functional-neurological-disorder
#3
Ingrid Hoeritzauer, Alan J Carson, Jon Stone
OBJECTIVE: In their 1973 BMJ paper 'Cryptogenic Drop Attacks', Stevens and Matthews described 40, mostly middle-aged, female patients with drop attacks of unknown cause. Although clinically common, there has been little on this topic since. We aimed to determine clinical features, comorbidity and outcome of patients with drop attacks. METHODS: We carried out a retrospective review of patients with cryptogenic drop attacks seen consecutively by one clinician (JS) between 2006 and 2016...
February 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29358889/systematic-review-of-colorectal-cancer-screening-guidelines-for-average-risk-adults-summarizing-the-current-global-recommendations
#4
Florence Bénard, Alan N Barkun, Myriam Martel, Daniel von Renteln
AIM: To summarize and compare worldwide colorectal cancer (CRC) screening recommendations in order to identify similarities and disparities. METHODS: A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website, Google and Google Scholar was performed...
January 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29351763/an-overview-of-the-impact-of-rare-disease-characteristics-on-research-methodology
#5
REVIEW
Danielle Whicher, Sarah Philbin, Naomi Aronson
BACKGROUND: About 30 million individuals in the United States are living with a rare disease, which by definition have a prevalence of 200,000 or fewer cases in the United States ([National Organization for Rare Disorders], [About NORD], [2016]). Disease heterogeneity and geographic dispersion add to the difficulty of completing robust studies in small populations. Improving the ability to conduct research on rare diseases would have a significant impact on population health. The purpose of this paper is to raise awareness of methodological approaches that can address the challenges to conducting robust research on rare diseases...
January 19, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29335899/the-ultrasonographic-whirlpool-sign-in-testicular-torsion-valuable-tool-or-waste-of-valuable-time-a-systematic-review-and-meta-analysis
#6
Jared McDowall, Ahmed Adam, Louis Gerber, Callistus O A Enyuma, Sunday J Aigbodion, Sean Buchanan, Abdullah E Laher
PURPOSE: A positive whirlpool sign (WS) is defined as the presence of a spiral-like pattern when the spermatic cord is assessed during ultrasonography (US), using standard, high-resolution ultrasonography (HRUS) and/or color Doppler sonography (CDS), in the presence of testicular torsion. The objective of this review was to assess the validity and accuracy of this sign by performing a comprehensive systematic literature review and meta-analysis. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, a comprehensive literature search was performed (August, 2017), using the following databases: BMJ Best Practice, Cochrane Library, Embase, PubMed, Scopus, and Web of Science...
January 15, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29329525/reporting-of-heterogeneity-of-treatment-effect-in-cohort-studies-a-review-of-the-literature
#7
Meryl Dahan, Caroline Scemama, Raphael Porcher, David J Biau
BACKGROUND: This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis. METHODS: prospective cohort studies, in English language, measuring the effect of a treatment (pharmacological, interventional, or other) published among 119 core clinical journals (defined by the National Library of Medicine) in the last 16 years were selected in the following data source: Medline...
January 12, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29281975/a-survey-of-prevalence-of-narrative-and-systematic-reviews-in-five-major-medical-journals
#8
Clovis Mariano Faggion, Nikolaos P Bakas, Jason Wasiak
BACKGROUND: Systematic reviews may provide less biased evidence than narrative reviews because they observe a strict methodology, similarly to primary studies. Hence, for clinical research questions, systematic reviews should be the study design of choice. It would be important to evaluate the prevalence and characteristics of narrative and systematic reviews published in prominent medical journals. Researchers and clinicians give great value to articles published in such scientific journals...
December 28, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29167735/a-review-of-data-sharing-statements-in-observational-studies-published-in-the-bmj-a-cross-sectional-study
#9
Laura McDonald, Anna Schultze, Alex Simpson, Sophie Graham, Radek Wasiak, Sreeram V Ramagopalan
In order to understand the current state of data sharing in observational research studies, we reviewed data sharing statements of observational studies published in a general medical journal, the British Medical Journal. We found that the majority (63%) of observational studies published between 2015 and 2017 included a statement that implied that data used in the study could not be shared. If the findings of our exploratory study are confirmed, room for improvement in the sharing of real-world or observational research data exists...
2017: F1000Research
https://www.readbyqxmd.com/read/29062538/gripp2-reporting-checklists-tools-to-improve-reporting-of-patient-and-public-involvement-in-research
#10
S Staniszewska, J Brett, I Simera, K Seers, C Mockford, S Goodlad, D G Altman, D Moher, R Barber, S Denegri, A Entwistle, P Littlejohns, C Morris, R Suleman, V Thomas, C Tysall
BACKGROUND: While the patient and public involvement (PPI) evidence base has expanded over the past decade, the quality of reporting within papers is often inconsistent, limiting our understanding of how it works, in what context, for whom, and why. OBJECTIVE: To develop international consensus on the key items to report to enhance the quality, transparency, and consistency of the PPI evidence base. To collaboratively involve patients as research partners at all stages in the development of GRIPP2...
2017: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29046090/is-the-number-of-new-trauma-and-orthopaedic-consultant-posts-increasing-or-decreasing
#11
REVIEW
S Wilson, Npm Jain, D S Johnson
Introduction Trauma and orthopaedics is a popular surgical specialty in the UK. Recent changes to the National Health Service have suggested an imbalance with fewer jobs yet more trainees. Furthermore, subspecialisation is emerging within all surgical disciplines. The aim of this study was to examine whether there were decreasing numbers of trauma and orthopaedic (T&O) consultant appointments in the UK, and to determine the frequency of subspecialisation. Methods All 51 issues of the British Medical Journal (BMJ) careers supplement from the year 2000 were reviewed as well as the 51 issues from 2010...
November 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28942418/clinical-trial-transparency-a-reassessment-of-industry-compliance-with-clinical-trial-registration-and-reporting-requirements-in-the-united-states
#12
Scott M Lassman, Olivia M Shopshear, Ina Jazic, Jocelyn Ulrich, Jeffrey Francer
OBJECTIVE: To evaluate the accuracy of a 2015 cross-sectional analysis published in the BMJ Open which reported that pharmaceutical industry compliance with clinical trial registration and results reporting requirements under US law was suboptimal and varied widely among companies. DESIGN: We performed a reassessment of the data reported in Miller et al to evaluate whether statutory compliance analyses and conclusions were valid. DATA SOURCES: Information from the Dryad Digital Repository, ClinicalTrials...
September 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28935653/consider-corticosteroids-for-acute-sore-throat-says-bmj-review
#13
Gareth Iacobucci
No abstract text is available yet for this article.
September 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28931508/corticosteroids-for-treatment-of-sore-throat-systematic-review-and-meta-analysis-of-randomised-trials
#14
REVIEW
Behnam Sadeghirad, Reed A C Siemieniuk, Romina Brignardello-Petersen, Davide Papola, Lyubov Lytvyn, Per Olav Vandvik, Arnaud Merglen, Gordon H Guyatt, Thomas Agoritsas
Objective To estimate the benefits and harms of using corticosteroids as an adjunct treatment for sore throat. Design Systematic review and meta-analysis of randomised control trials. Data sources Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), trial registries up to May 2017, reference lists of eligible trials, related reviews. Study selection Randomised controlled trials of the addition of corticosteroids to standard clinical care for patients aged 5 or older in emergency department and primary care settings with clinical signs of acute tonsillitis, pharyngitis, or the clinical syndrome of sore throat...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#15
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28898961/the-economic-impact-of-workplace-wellness-programmes-in-canada
#16
J C Jacobs, E Yaquian, S M Burke, M Rouse, G Zaric
Background: The economic benefits of workplace wellness programmes (WWPs) are commonly cited as a reason for employers to implement such programmes; however, there is limited evidence outside of the US context exploring their economic impact. US evidence is less relevant in countries such as Canada with universal publicly funded health systems because of the lower potential employer savings from WWPs. Aims: To conduct a systematic review of the Canadian literature investigating the economic impact of WWPs from an employer perspective...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28893759/values-and-preferences-of-women-living-with-hiv-who-are-pregnant-postpartum-or-considering-pregnancy-on-choice-of-antiretroviral-therapy-during-pregnancy
#17
Lyubov Lytvyn, Reed A Siemieniuk, Sophie Dilmitis, Allyson Ion, Yaping Chang, Malgorzata M Bala, Veena Manja, Reza Mirza, Rene Rodriguez-Gutierrez, Hassan Mir, Laura Banfield, Per Olav Vandvik, Susan Bewley
OBJECTIVE: To investigate women's values and preferences regarding antiretroviral therapy (ART) during pregnancy to inform a BMJ Rapid Recommendation. SETTING: Primary studies reporting patient-reported outcomes relevant to decision-making regarding ART in any clinical and geographical setting. PARTICIPANTS: Women living with HIV who are pregnant, postpartum or considering pregnancy. OUTCOME MEASURES: Quantitative measurements and qualitative descriptions of values and preferences in relation to ART during pregnancy...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28842548/thank-you-to-our-reviewers-2016
#18
Bmj Production
No abstract text is available yet for this article.
September 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28768629/gripp2-reporting-checklists-tools-to-improve-reporting-of-patient-and-public-involvement-in-research
#19
S Staniszewska, J Brett, I Simera, K Seers, C Mockford, S Goodlad, D G Altman, D Moher, R Barber, S Denegri, A Entwistle, P Littlejohns, C Morris, R Suleman, V Thomas, C Tysall
Background While the patient and public involvement (PPI) evidence base has expanded over the past decade, the quality of reporting within papers is often inconsistent, limiting our understanding of how it works, in what context, for whom, and why.Objective To develop international consensus on the key items to report to enhance the quality, transparency, and consistency of the PPI evidence base. To collaboratively involve patients as research partners at all stages in the development of GRIPP2.Methods The EQUATOR method for developing reporting guidelines was used...
August 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28667229/corticosteroids-in-sepsis-an-updated-systematic-review-and-meta-analysis-protocol
#20
Bram Rochwerg, Simon Oczkowski, Reed Alexander Siemieniuk, Kusum Menon, Wojciech Szczeklik, Shane English, Thomas Agoritsas, Emilie Belley-Cote, Frédérick D'Aragon, Waleed Alhazzani, Erick Duan, Kira Gossack-Keenan, Jon Sevransky, Per Vandvik, Bala Venkatesh, Gordon Guyatt, Djillali Annane
INTRODUCTION: Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature...
June 30, 2017: BMJ Open
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