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L Jefferson, C Fairhurst, E Cooper, C Hewitt, T Torgerson, L Cook, P Tharmanathan, S Cockayne, D Torgerson
OBJECTIVE: Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DESIGN: Literature searches were carried out in four general medical journals from June 2013 to June 2014 inclusive (BMJ, JAMA, the Lancet and the New England Journal of Medicine)...
October 2016: JRSM Open
Anisa Rowhani-Farid, Adrian G Barnett
OBJECTIVE: To quantify data sharing trends and data sharing policy compliance at the British Medical Journal (BMJ) by analysing the rate of data sharing practices, and investigate attitudes and examine barriers towards data sharing. DESIGN: Observational study. SETTING: The BMJ research archive. PARTICIPANTS: 160 randomly sampled BMJ research articles from 2009 to 2015, excluding meta-analysis and systematic reviews...
October 13, 2016: BMJ Open
Romain Rivoirard, Vianney Duplay, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Nicolas Magne, Aurelie Bourmaud
BACKGROUND: Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. METHODS: From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC)...
2016: PloS One
Lun Li, Ferrán Catalá-López, Adolfo Alonso-Arroyo, Jinhui Tian, Rafael Aleixandre-Benavent, Dawid Pieper, Long Ge, Liang Yao, Quan Wang, Kehu Yang
BACKGROUND AND OBJECTIVE: Research collaborations in biomedical research have evolved over time. No studies have addressed research collaboration in network meta-analysis (NMA). In this study, we used social network analysis methods to characterize global collaboration patterns of published NMAs over the past decades. METHODS: PubMed, EMBASE, Web of Science and the Cochrane Library were searched (at 9th July, 2015) to include systematic reviews incorporating NMA...
2016: PloS One
Farzaneh Agha-Hosseini, Nafiseh Sheykhbahaei, Maryam-Sadat SadrZadeh-Afshar
AIM: Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. INTRODUCTION: World Health Organization (WHO) classifies OLP as a "potentially malignant disorder" with unspecified malignant transformation risk, and suggests that OLP patients should be closely monitored...
2016: Journal of Contemporary Dental Practice
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
September 20, 2016: Quality of Life Research
Chezhan Hall, Maria Murphy, Andrew Scanlon
BACKGROUND: Phase one cardiac rehabilitation (CR) is an essential component of care for patients with coronary heart disease. With optimal program delivery, health outcomes can be improved. OBJECTIVES: To conduct an integrative review that explores Phase one CR for patients hospitalised with coronary heart disease. DESIGN: Integrative literature review (2003-2014) Data sources: The literature search included Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Experta Medica Database (EMBASE), Psycinfo, Clinical Practice Guidelines Portal, Cochrane Library, Clinical Evidence (BMJ) and Google Scholar...
September 7, 2016: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Meredith Hays, Mary Andrews, Ramey Wilson, David Callender, Patrick G O'Malley, Kevin Douglas
OBJECTIVE: The aim of this study was to assess adherence to the Consolidated Standards of Reporting Trials (CONSORT) for Abstracts by five high-impact general medical journals and to assess whether the quality of reporting was homogeneous across these journals. DESIGN: This is a descriptive, cross-sectional study. SETTING: Randomised controlled trial (RCT) abstracts in five high-impact general medical journals. PARTICIPANTS: We used up to 100 RCT abstracts published between 2011 and 2014 from each of the following journals: The New England Journal of Medicine (NEJM), the Annals of Internal Medicine (Annals IM), The Lancet, the British Medical Journal (The BMJ) and the Journal of the American Medical Association (JAMA)...
July 28, 2016: BMJ Open
Roberto Sorrentino, Maria Irene Di Mauro, Marco Ferrari, Renato Leone, Fernando Zarone
OBJECTIVE: The present systematic review aimed at assessing data from the literature on endodontic and prosthetic complications in endodontically treated teeth restored with fiber posts and single crowns (SCs) or fixed dental prostheses (FDPs). MATERIALS AND METHODS: Available randomized controlled clinical trials evaluating endodontic and prosthetic complications in the teeth treated with fiber posts and restored with different prosthetic restorations were reviewed...
September 2016: Clinical Oral Investigations
Olga Meulenbroek, Sarah O'Dwyer, Daan de Jong, Gerrita van Spijker, Sean Kennelly, Fiona Cregg, Marcel Olde Rikkert, Laila Abdullah, Anders Wallin, Cathal Walsh, Robert Coen, Rose Anne Kenny, Leslie Daly, Ricardo Segurado, Anne Borjesson-Hanson, Fiona Crawford, Michael Mullan, Ugo Lucca, Rita Banzi, Florence Pasquier, Laetitia Breuilh, Matthias Riepe, Janos Kalman, William Molloy, Magda Tsolaki, Robert Howard, Jessica Adams, Siobhan Gaynor, Brian Lawlor
INTRODUCTION: In conjunction with the NILVAD trial, a European Multicentre Double-Blind Placebo Controlled trial of Nilvadipine in Mild-to-Moderate Alzheimer's disease (AD), there are four NILVAD substudies in which eligible NILVAD patients are also invited to participate. The main NILVAD protocol was previously published in BMJ Open (2014). The objectives of the NILVAD substudies are to determine whether frailty, cerebrospinal fluid (CSF), blood biomarker profile and Apolipoprotein E (APOE) status predict response to Nilvadipine, and to investigate the effect of Nilvadipine on cerebral blood flow and blood biomarkers...
2016: BMJ Open
Adriaan Louw, Ina Diener, César Fernández-de-Las-Peñas, Emilio J Puentedura
OBJECTIVE: To evaluate the evidence for the effectiveness of sham surgery in orthopedics by conducting a systematic review of literature. METHODS: Systematic searches were conducted on Biomed Central,, CINAHL, the Cochrane Library, NLM Central Gateway, OVID, ProQuest (Digital Dissertations), PsycInfo, PubMed/Medline, ScienceDirect and Web of Science. Secondary searching (PEARLing) was undertaken, whereby reference lists of the selected articles were reviewed for additional references not identified in the primary search...
July 11, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
D Stengel, S Kirschner, A Ekkernkamp, C Bartl
The article "Evidence based medicine: what it is and what it isn't" published in the BMJ in 1996, is regarded as the foundation of the evidence-based medicine (EbM) movement. Approximately 5 years later David L. Sackett, one of the leaders of the movement, requested all experts to voluntarily abandon their position to make way for young researchers and fresh ideas. Since the term was first coined and the establishment of organizations and platforms fostering the idea, EbM has polarized clinicians and scientists around the world...
September 2016: Der Unfallchirurg
Chelsey M Toney, Kenneth E Games, Zachary K Winkelmann, Lindsey E Eberman
REFERENCE/CITATION: Mugunthan K, Doust J, Kurz B, Glasziou P. Is there sufficient evidence for tuning fork tests in diagnosing fractures? A systematic review. BMJ Open. 2014;4(8):e005238. CLINICAL QUESTION: Does evidence support the use of tuning-fork tests in the diagnosis of fractures in clinical practice? DATA SOURCES: The authors performed a comprehensive literature search of AMED, CAB Abstracts, CINAHL, EMBASE, MEDLINE, SPORTDiscus, and Web of Science from each database's start to November 2012...
June 2, 2016: Journal of Athletic Training
David B Clark
Hollands et al recently published a systematic review in the BMJ on the impact of communicating genetic risk of disease on risk-reducing behavior. (Hollands, 2016) The basic premise was to ask if communicating genetic risk factors for certain diseases would be sufficient to cause behavior change in individuals. Specifically, would this be sufficient to cause a change in behaviors related to the development of the disease at risk. This article is protected by copyright. All rights reserved.
May 26, 2016: Oral Diseases
J P Windfuhr
BACKGROUND: One of the most significant clinical trials, demonstrating the efficacy of tonsillectomy (TE) for recurrent throat infection in severely affected children, was published in 1984. This systematic review was undertaken to compile various indications for TE as suggested in the literature after 1984 and to stratify the papers according to the current concept of Evidence-based Medicine. MATERIAL AND METHODS: A systematic Medline research was performed using the key word "tonsillectomy" in combination with different filters such as "systematic reviews", "meta-analysis", "English", "German" and "from 1984/01/01 to 2015/05/31"...
April 2016: Laryngo- Rhino- Otologie
Jennifer Weston, Kerry Dwan, Douglas Altman, Mike Clarke, Carrol Gamble, Sara Schroter, Paula Williamson, Jamie Kirkham
OBJECTIVES: Adding, omitting or changing prespecified outcomes can result in bias because it increases the potential for unacknowledged or post hoc revisions of the planned analyses. Journals have adopted initiatives such as requiring the prospective registration of trials and the submission of study protocols to promote the transparency of reporting in clinical trials. The main objective of this feasibility study was to document the frequency and types of outcome discrepancy between prespecified outcomes in the protocol and reported outcomes in trials submitted to The BMJ...
2016: BMJ Open
Lauren Porras, Jonathan Drezner, Andrea Dotson, Harry Stafford, David Berkoff, Eugene H Chung
INTRODUCTION: It is not known whether there is a specific training method that improves the accuracy of physician interpretations of pre-participation electrocardiograms (ECGs). METHODS: Participants took an online test and interpreted a series of normal, normal variant and abnormal ECGs. They then reviewed the BMJ's ECG interpretation online learning module and completed a post-test and a follow-up examination three months later. RESULTS: 28 fellows enrolled...
May 2016: Journal of Electrocardiology
Nadia Elia, Erik von Elm, Alexandra Chatagner, Daniel M Pöpping, Martin R Tramèr
OBJECTIVES: To study whether systematic reviewers apply procedures to counter-balance some common forms of research malpractice such as not publishing completed research, duplicate publications, or selective reporting of outcomes, and to see whether they identify and report misconduct. DESIGN: Cross-sectional analysis of systematic reviews and survey of their authors. PARTICIPANTS: 118 systematic reviews published in four journals (Ann Int Med, BMJ, JAMA, Lancet), and the Cochrane Library, in 2013...
2016: BMJ Open
Koffi Alouki, Hélène Delisle, Clara Bermúdez-Tamayo, Mira Johri
Objective. To summarize key findings of economic evaluations of lifestyle interventions for the primary prevention of type 2 diabetes (T2D) in high-risk subjects. Methods. We conducted a systematic review of peer-reviewed original studies published since January 2009 in English, French, and Spanish. Eligible studies were identified through relevant databases including PubMed, Medline, National Health Services Economic Evaluation, CINHAL, EconLit, Web of sciences, EMBASE, and the Latin American and Caribbean Health Sciences Literature...
2016: Journal of Diabetes Research
Reema Harrison, Merrilyn Walton, Judith Healy, Jennifer Smith-Merry, Coletta Hobbs
OBJECTIVE: To explore the applicability of a patient complaint taxonomy to data on serious complaint cases. DESIGN: Qualitative descriptive study. SETTING: Complaints made to the New South Wales (NSW) Health Care Complaints Commission, Australia between 2005 and 2010. PARTICIPANTS: All 138 cases of serious complaints by patients about public hospitals and other health facilities investigated in the 5-year period. MAIN OUTCOME MEASURE: A thematic analysis of the complaints was conducted to identify particular complaint issues and the Reader et al...
April 2016: International Journal for Quality in Health Care
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