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https://www.readbyqxmd.com/read/28942418/clinical-trial-transparency-a-reassessment-of-industry-compliance-with-clinical-trial-registration-and-reporting-requirements-in-the-united-states
#1
Scott M Lassman, Olivia M Shopshear, Ina Jazic, Jocelyn Ulrich, Jeffrey Francer
OBJECTIVE: To evaluate the accuracy of a 2015 cross-sectional analysis published in the BMJ Open which reported that pharmaceutical industry compliance with clinical trial registration and results reporting requirements under US law was suboptimal and varied widely among companies. DESIGN: We performed a reassessment of the data reported in Miller et al to evaluate whether statutory compliance analyses and conclusions were valid. DATA SOURCES: Information from the Dryad Digital Repository, ClinicalTrials...
September 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28935653/consider-corticosteroids-for-acute-sore-throat-says-bmj-review
#2
Gareth Iacobucci
No abstract text is available yet for this article.
September 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28931508/corticosteroids-for-treatment-of-sore-throat-systematic-review-and-meta-analysis-of-randomised-trials
#3
REVIEW
Behnam Sadeghirad, Reed A C Siemieniuk, Romina Brignardello-Petersen, Davide Papola, Lyubov Lytvyn, Per Olav Vandvik, Arnaud Merglen, Gordon H Guyatt, Thomas Agoritsas
Objective To estimate the benefits and harms of using corticosteroids as an adjunct treatment for sore throat.Design Systematic review and meta-analysis of randomised control trials.Data sources Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), trial registries up to May 2017, reference lists of eligible trials, related reviews.Study selection Randomised controlled trials of the addition of corticosteroids to standard clinical care for patients aged 5 or older in emergency department and primary care settings with clinical signs of acute tonsillitis, pharyngitis, or the clinical syndrome of sore throat...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#4
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28898961/the-economic-impact-of-workplace-wellness-programmes-in-canada
#5
J C Jacobs, E Yaquian, S M Burke, M Rouse, G Zaric
Background: The economic benefits of workplace wellness programmes (WWPs) are commonly cited as a reason for employers to implement such programmes; however, there is limited evidence outside of the US context exploring their economic impact. US evidence is less relevant in countries such as Canada with universal publicly funded health systems because of the lower potential employer savings from WWPs. Aims: To conduct a systematic review of the Canadian literature investigating the economic impact of WWPs from an employer perspective...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28893759/values-and-preferences-of-women-living-with-hiv-who-are-pregnant-postpartum-or-considering-pregnancy-on-choice-of-antiretroviral-therapy-during-pregnancy
#6
Lyubov Lytvyn, Reed A Siemieniuk, Sophie Dilmitis, Allyson Ion, Yaping Chang, Malgorzata M Bala, Veena Manja, Reza Mirza, Rene Rodriguez-Gutierrez, Hassan Mir, Laura Banfield, Per Olav Vandvik, Susan Bewley
OBJECTIVE: To investigate women's values and preferences regarding antiretroviral therapy (ART) during pregnancy to inform a BMJ Rapid Recommendation. SETTING: Primary studies reporting patient-reported outcomes relevant to decision-making regarding ART in any clinical and geographical setting. PARTICIPANTS: Women living with HIV who are pregnant, postpartum or considering pregnancy. OUTCOME MEASURES: Quantitative measurements and qualitative descriptions of values and preferences in relation to ART during pregnancy...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28842548/thank-you-to-our-reviewers-2016
#7
Bmj Production
No abstract text is available yet for this article.
September 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28768629/gripp2-reporting-checklists-tools-to-improve-reporting-of-patient-and-public-involvement-in-research
#8
S Staniszewska, J Brett, I Simera, K Seers, C Mockford, S Goodlad, D G Altman, D Moher, R Barber, S Denegri, A Entwistle, P Littlejohns, C Morris, R Suleman, V Thomas, C Tysall
Background While the patient and public involvement (PPI) evidence base has expanded over the past decade, the quality of reporting within papers is often inconsistent, limiting our understanding of how it works, in what context, for whom, and why.Objective To develop international consensus on the key items to report to enhance the quality, transparency, and consistency of the PPI evidence base. To collaboratively involve patients as research partners at all stages in the development of GRIPP2.Methods The EQUATOR method for developing reporting guidelines was used...
August 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28667229/corticosteroids-in-sepsis-an-updated-systematic-review-and-meta-analysis-protocol
#9
Bram Rochwerg, Simon Oczkowski, Reed Alexander Siemieniuk, Kusum Menon, Wojciech Szczeklik, Shane English, Thomas Agoritsas, Emilie Belley-Cote, Frédérick D'Aragon, Waleed Alhazzani, Erick Duan, Kira Gossack-Keenan, Jon Sevransky, Per Vandvik, Bala Venkatesh, Gordon Guyatt, Djillali Annane
INTRODUCTION: Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28618323/a-systematic-review-of-trends-in-the-selective-exclusion-of-older-participant-from-randomised-clinical-trials
#10
REVIEW
Miriam Thake, Andrew Lowry
INTRODUCTION: The unjustified exclusion of older participants from clinical trials creates research populations that are non-representative, in turn creating difficulties applying research to the target populations. The aim of this study was to assess the proportion of randomised control trials (RCTs) that have unexplained upper age limits and review whether this proportion is reducing over time. METHODS: All RCTs in BMJ, Lancet, JAMA and NEJM from 1998 to 2015 were reviewed to identify any specified upper-age cut off and, if so, whether this exclusion criterion had an explanation in the text...
September 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28570411/review-of-medical-error-the-third-leading-cause-of-death-in-the-us-by-makary-ma-and-daniel-m-in-bmj-353-i2139-2016
#11
Kristina P Marsack, Larry H Hollier
No abstract text is available yet for this article.
July 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28495819/knee-arthroscopy-versus-conservative-management-in-patients-with-degenerative-knee-disease-a-systematic-review
#12
Romina Brignardello-Petersen, Gordon H Guyatt, Rachelle Buchbinder, Rudolf W Poolman, Stefan Schandelmaier, Yaping Chang, Behnam Sadeghirad, Nathan Evaniew, Per O Vandvik
OBJECTIVE: To determine the effects and complications of arthroscopic surgery compared with conservative management strategies in patients with degenerative knee disease. DESIGN: Systematic review. MAIN OUTCOME MEASURES: Pain, function, adverse events. DATA SOURCES: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar and Open Grey up to August 2016. ELIGIBILITY CRITERIA: For effects, randomised clinical trials (RCTs) comparing arthroscopic surgery with a conservative management strategy (including sham surgery) in patients with degenerative knee disease...
May 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28495818/application-of-minimal-important-differences-in-degenerative-knee-disease-outcomes-a-systematic-review-and-case-study-to-inform-bmj-rapid-recommendations
#13
Tahira Devji, Gordon H Guyatt, Lyubov Lytvyn, Romina Brignardello-Petersen, Farid Foroutan, Behnam Sadeghirad, Rachelle Buchbinder, Rudolf W Poolman, Ian A Harris, Alonso Carrasco-Labra, Reed A C Siemieniuk, Per O Vandvik
OBJECTIVES: To identify the most credible anchor-based minimal important differences (MIDs) for patient important outcomes in patients with degenerative knee disease, and to inform BMJ Rapid Recommendations for arthroscopic surgery versus conservative management DESIGN: Systematic review. OUTCOME MEASURES: Estimates of anchor-based MIDs, and their credibility, for knee symptoms and health-related quality of life (HRQoL). DATA SOURCES: MEDLINE, EMBASE and PsycINFO...
May 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28396612/efficacy-of-nucleot-s-ide-analogs-therapy-in-patients-with-unresectable-hbv-related-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#14
REVIEW
Lingling He, Xiaoli Liu, Yalin Zhao, Shuan Zhang, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
Aim. To determine whether nucleot(s)ide analogs therapy has survival benefit for patients with HBV-related HCC after unresectable treatment. Method. A systematic search was conducted through seven electronic databases including PubMed, OVID, EMBASE, Cochrane Databases, Elsevier, Wiley Online Library, and BMJ Best Practice. All studies comparing NA combined with unresectable treatment versus unresectable treatment alone were considered for inclusion. The primary outcome was the overall survival (OS) after unresectable treatment for patients with HBV-related HCC...
2017: Disease Markers
https://www.readbyqxmd.com/read/28372534/panel-7-otitis-media-treatment-and-complications
#15
REVIEW
Anne G M Schilder, Tal Marom, Mahmood F Bhutta, Margaretha L Casselbrant, Harvey Coates, Marie Gisselsson-Solén, Amanda J Hall, Paola Marchisio, Aino Ruohola, Roderick P Venekamp, Ellen M Mandel
Objective We aimed to summarize key articles published between 2011 and 2015 on the treatment of (recurrent) acute otitis media, otitis media with effusion, tympanostomy tube otorrhea, chronic suppurative otitis media and complications of otitis media, and their implications for clinical practice. Data Sources PubMed, Ovid Medline, the Cochrane Library, and Clinical Evidence (BMJ Publishing). Review Methods All types of articles related to otitis media treatment and complications between June 2011 and March 2015 were identified...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28372469/the-influence-of-zinc-sulfate-on-neonatal-jaundice-a-systematic-review-and-meta-analysis
#16
Li Yang, De Wu, Baotian Wang, Xiaosong Bu, Jiulai Tang
INTRODUCTION: Zinc sulfate may be a promising approach to treat neonatal jaundice. However, the results remain controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of zinc sulfate on hyperbilirubinemia among neonates. METHODS: PubMed, EMbase, Web of science, EBSCO, Cochrane library databases, Ovid, BMJ database, and CINAHL were systematically searched. Randomized controlled trials (RCTs) assessing the effect of zinc sulfate versus placebo on the prevention of jaundice in neonates were included...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28348110/low-intensity-pulsed-ultrasound-for-bone-healing-systematic-review-of-randomized-controlled-trials
#17
REVIEW
Stefan Schandelmaier, Alka Kaushal, Lyubov Lytvyn, Diane Heels-Ansdell, Reed A C Siemieniuk, Thomas Agoritsas, Gordon H Guyatt, Per O Vandvik, Rachel Couban, Brent Mollon, Jason W Busse
Objective To determine the efficacy of low intensity pulsed ultrasound (LIPUS) for healing of fracture or osteotomy.Design Systematic review and meta-analysis.Data sources Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials, and trial registries up to November 2016.Study selection Randomized controlled trials of LIPUS compared with sham device or no device in patients with any kind of fracture or osteotomy.Review methods Two independent reviewers identified studies, extracted data, and assessed risk of bias...
February 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28264797/standards-for-reporting-implementation-studies-stari-statement
#18
Hilary Pinnock, Melanie Barwick, Christopher R Carpenter, Sandra Eldridge, Gonzalo Grandes, Chris J Griffiths, Jo Rycroft-Malone, Paul Meissner, Elizabeth Murray, Anita Patel, Aziz Sheikh, Stephanie J C Taylor
Implementation studies are often poorly reported and indexed, reducing their potential to inform initiatives to improve healthcare services. The Standards for Reporting Implementation Studies (StaRI) initiative aimed to develop guidelines for transparent and accurate reporting of implementation studies. Informed by the findings of a systematic review and a consensus-building e-Delphi exercise, an international working group of implementation science experts discussed and agreed the StaRI Checklist comprising 27 items...
March 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28159431/cost-effectiveness-of-ambulatory-blood-pressure-monitoring-in-the-management-of-hypertension
#19
Diogo Costa, Ricardo Peixoto Lima
INTRODUCTION AND OBJECTIVES: The prevalence of hypertension in Portugal is between 29.1% and 42.2%. International studies show that 13% of individuals have masked hypertension and 13% of diagnoses based on office blood pressure measurements are in fact white coat hypertension. More sensitive and specific blood pressure measuring methods could avoid costs associated with misdiagnosis. The aim of this study was to review the cost-effectiveness of ambulatory blood pressure monitoring (ABPM) compared to other methods in the management of hypertension...
February 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28126598/reporting-of-data-monitoring-boards-in-publications-of-randomized-clinical-trials-is-often-deficient-acttion-systematic-review
#20
REVIEW
Jennifer S Gewandter, Rachel A Kitt, Matthew R Hunsinger, Joseph Poku, Jacqueline Lozano, Jenna Chaudari, Scott Evans, Robert A Gross, Michael P McDermott, Michael C Rowbotham, Dennis C Turk, Robert H Dworkin
OBJECTIVE: To examine whether primary reports of randomized clinical trials (RCTs) in six high-impact, general medical journals reported (1) whether or not a Data Monitoring Committee/Data and Safety Monitoring Board (DMC/DSMB) was used and (2) the composition of the responsibilities of the reported DSMB/DMCs. STUDY DESIGN AND SETTING: Systematic review of RCTs published in 2014 in Annals of Internal Medicine, BMJ, NEJM, JAMA, JAMA Internal Medicine, and Lancet...
March 2017: Journal of Clinical Epidemiology
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