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https://www.readbyqxmd.com/read/27717876/programmed-death-pd-1-attenuates-macrophage-activation-and-brain-inflammation-via-regulation-of-fibrinogen-like-protein-2-fgl-2-after-intracerebral-hemorrhage-in-mice
#1
Bangqing Yuan, Shaokuan Huang, Shuangfeng Gong, Feihong Wang, Li Lin, Tonggang Su, Hanchao Sheng, Hui Shi, Kunlong Ma, Zhao Yang
Neuroinflammation plays an important role in the recovery of brain injury in ICH. Macrophage is the major executor in the neuroinflammation and initiates neurological defects. Programmed death 1 (PD-1) delivers inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. PD-1 expression by macrophages plays a pathologic role in the innate inflammatory response. However, the exact role of PD-1 on inflammatory responses following ICH has not been well identified. In this experiment, PD-1 KO (PD-1 -/-) ICH mice and Wild-type (WT) ICH mice were caused by intracranial injection of type IV collagenase...
October 4, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27709492/c5a-c5ar-pathway-plays-a-vital-role-in-brain-inflammatory-injury-via-initiating-fgl-2-in-intracerebral-hemorrhage
#2
Bangqing Yuan, Fenlan Fu, Shaokuan Huang, Chuangan Lin, Guang Yang, Kunlong Ma, Hui Shi, Zhao Yang
Intracerebral hemorrhage (ICH) is a serious emergency with high mortality and morbidity. Up to date, a limited understanding of ICH pathogenesis is difficult to implement effective therapeutic strategy. Much evidence demonstrates that the complement cascade is activated after experimental ICH. However, the exact mechanism has not been well studied in ICH. In the current study, C57BL/6J mice were injected with autologous whole blood. C5a/C5aR levels, microglia infiltration, inflammatory cytokine, and fibrinogen-like protein 2 (Fgl-2) expression in the perihematomal region were analyzed following ICH...
October 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27507539/structural-basis-for-myf-and-psa-fimbriae-mediated-tropism-of-pathogenic-strains-of-yersinia-for-host-tissues
#3
Natalia Pakharukova, Saumendra Roy, Minna Tuittila, Mohammad M Rahman, Sari Paavilainen, Anna-Karin Ingars, Maksym Skaldin, Urpo Lamminmäki, Torleif Härd, Susann Teneberg, Anton V Zavialov
Three pathogenic species of the genus Yersinia assemble adhesive fimbriae via the FGL-chaperone/usher pathway. Closely related Y. pestis and Y. pseudotuberculosis elaborate the pH6 antigen (Psa), which mediates bacterial attachment to alveolar cells of the lung. Y. enterocolitica, instead, assembles the homologous fimbriae Myf of unknown function. Here, we discovered that Myf, like Psa, specifically recognizes β1-3- or β1-4-linked galactose in glycosphingolipids, but completely lacks affinity for phosphatidylcholine, the main receptor for Psa in alveolar cells...
November 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27352075/the-neural-cell-adhesion-molecule-derived-ncam-peptide-fg-loop-fgl-mobilizes-endogenous-neural-stem-cells-and-promotes-endogenous-regenerative-capacity-after-stroke
#4
Rebecca Klein, Nicolas Mahlberg, Maurice Ohren, Anne Ladwig, Bernd Neumaier, Rudolf Graf, Mathias Hoehn, Morten Albrechtsen, Stephen Rees, Gereon Rudolf Fink, Maria Adele Rueger, Michael Schroeter
The neural cell adhesion molecule (NCAM)-derived peptide FG loop (FGL) modulates synaptogenesis, neurogenesis, and stem cell proliferation, enhances cognitive capacities, and conveys neuroprotection after stroke. Here we investigated the effect of subcutaneously injected FGL on cellular compartments affected by degeneration and regeneration after stroke due to middle cerebral artery occlusion (MCAO), namely endogenous neural stem cells (NSC), oligodendrocytes, and microglia. In addition to immunohistochemistry, we used non-invasive positron emission tomography (PET) imaging with the tracer [(18)F]-fluoro-L-thymidine ([(18)F]FLT) to visualize endogenous NSC in vivo...
June 28, 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/27132874/functional-organization-of-the-fusiform-gyrus-revealed-with-connectivity-profiles
#5
Wen Zhang, Jiaojian Wang, Lingzhong Fan, Yuanchao Zhang, Peter T Fox, Simon B Eickhoff, Chunshui Yu, Tianzi Jiang
Within the object recognition-related ventral visual stream, the human fusiform gyrus (FG), which topographically connects the striate cortex to the inferior temporal lobe, plays a pivotal role in high-level visual/cognitive functions. However, though there are many previous investigations of distinct functional modules within the FG, the functional organization of the whole FG in its full functional heterogeneity has not yet been established. In the current study, a replicable functional organization of the FG based on distinct anatomical connectivity patterns was identified...
August 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27113684/utsa-74-a-mof-74-isomer-with-two-accessible-binding-sites-per-metal-center-for-highly-selective-gas-separation
#6
Feng Luo, Changsheng Yan, Lilong Dang, Rajamani Krishna, Wei Zhou, Hui Wu, Xinglong Dong, Yu Han, Tong-Liang Hu, Michael O'Keeffe, Lingling Wang, Mingbiao Luo, Rui-Biao Lin, Banglin Chen
A new metal-organic framework Zn2(H2O)(dobdc)·0.5(H2O) (UTSA-74, H4dobdc = 2,5-dioxido-1,4-benzenedicarboxylic acid), Zn-MOF-74/CPO-27-Zn isomer, has been synthesized and structurally characterized. It has a novel four coordinated fgl topology with one-dimensional channels of about 8.0 Å. Unlike metal sites in the well-established MOF-74 with a rod-packing structure in which each of them is in a five coordinate square pyramidal coordination geometry, there are two different Zn(2+) sites within the binuclear secondary building units in UTSA-74 in which one of them (Zn1) is in a tetrahedral while another (Zn2) in an octahedral coordination geometry...
May 4, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27095082/pharmacological-approach-for-targeting-dysfunctional-brain-plasticity-focus-on-neural-cell-adhesion-molecule-ncam
#7
REVIEW
Anu Aonurm-Helm, Külli Jaako, Monika Jürgenson, Alexander Zharkovsky
Brain plasticity refers to the ability of the brain to undergo functionally relevant adaptations in response to external and internal stimuli. Alterations in brain plasticity have been associated with several neuropsychiatric disorders, and current theories suggest that dysfunctions in neuronal circuits and synaptogenesis have a major impact in the development of these diseases. Among the molecules that regulate brain plasticity, neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM have been of particular interest for years because alterations in NCAM and PSA-NCAM levels have been associated with memory impairment, depression, autistic spectrum disorders and schizophrenia...
November 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27073463/preparation-of-a-novel-composite-nanofiber-gel-encapsulated-human-placental-extract-through-layer-by-layer-self-assembly
#8
Guohui Liu, X I Chen, W U Zhou, Shuhua Yang, Shunan Ye, Faqi Cao, Y I Liu, Yuan Xiong
Aqueous human placenta extract (HPE) has been previously used to treat chronic soft tissue ulcer; however, the optimal dosage of HPE has yet to be elucidated. The present study investigated a novel nanofiber gel composed through layer-by-layer (LbL) self-assembly, in which HPE was encapsulated. IKVAV, RGD, RAD16 and FGL-PA were screened and combined to produce an optimal vehicle nanofiber gel through LbL assembly. Subsequently, the aqueous HPE was encapsulated into this nanofiber at the appropriate concentration, and the morphology, particle size, drug loading efficacy, encapsulation rate, release efficiency and structure validation were detected...
April 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26862043/ameliorative-effects-of-curcumin-on-fibrinogen-like-protein-2-gene-expression-some-oxido-inflammatory-and-apoptotic-markers-in-a-rat-model-of-l-arginine-induced-acute-pancreatitis
#9
Noha M Shafik, Ghada M Abou-Fard
The aim of the study was to investigate the ameliorative effects of curcumin on fibrinogen like protein-2 (fgl-2), some oxido-inflammatory and apoptotic markers in rat-induced acute pancreatitis (AP). Seventy-five albino rats were divided into control group, l-arginine (l-Arg)-induced AP group, curcumin pre-treated group before AP induction, curcumin post-treated group after AP induction, and curcumin injected group only. AP group showed severe necrotizing pancreatitis confirmed by histopathological changes and elevations in serum amylase and lipase activities, levels of epithelial neutrophil-activating peptide 78, tissue content of protein carbonyls, levels of tumor necrosis factor α, and caspase-3 as well as myeloperoxidase activity...
June 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/26513739/identification-of-the-fgl-amide-allatostatin-gene-of-the-primitive-termite-mastotermes-darwiniensis-and-the-woodroach-cryptocercus-darwini
#10
Franziska Wende, Martina Meyering-Vos, Klaus H Hoffmann
Allatostatins with the C-terminal ending Tyr/Phe-Xaa-Phe-Gly-Leu/Ile-amide (FGLa/ASTs) are widespread neuropeptides with multiple functions. The gene encoding the FGLa/AST polypeptide precursor was first isolated from cockroaches and since then could be identified in many insects and crustaceans. With its strictly conserved regions in combination with variable regions the gene seems to be a good candidate for phylogenetic analyses between closely and distantly related species. Here, the structure of the FGLa/AST gene of the most primitive termite, the giant northern termite Mastotermes darwiniensis Froggatt, was identified...
February 2016: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/26279369/forced-degradation-of-fingolimod-effect-of-co-solvent-and-characterization-of-degradation-products-by-uhplc-q-tof-ms-ms-and-1h-nmr
#11
Prinesh N Patel, Pradipbhai D Kalariya, S Gananadhamu, R Srinivas
Fingolimod (FGL), an immunomodulator drug for treating multiple sclerosis, was subjected to hydrolysis (acidic, alkaline and neutral), oxidation, photolysis and thermal stress, as per International Conference on Harmonization specified conditions. The drug showed extensive degradation under base hydrolysis, however, it was stable under all other conditions. A total of three degradation products (DPs) were observed. The chromatographic separation of the drug and its degradation products was achieved on a Fortis C18 (100×2...
November 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26135459/unravelling-the-evolution-of-the-allatostatin-type-a-kiss-and-galanin-peptide-receptor-gene-families-in-bilaterians-insights-from-anopheles-mosquitoes
#12
Rute C Felix, Marlene Trindade, Isa R P Pires, Vera G Fonseca, Rute S Martins, Henrique Silveira, Deborah M Power, João C R Cardoso
UNLABELLED: Allatostatin type A receptors (AST-ARs) are a group of G-protein coupled receptors activated by members of the FGL-amide (AST-A) peptide family that inhibit food intake and development in arthropods. Despite their physiological importance the evolution of the AST-A system is poorly described and relatively few receptors have been isolated and functionally characterised in insects. The present study provides a comprehensive analysis of the origin and comparative evolution of the AST-A system...
2015: PloS One
https://www.readbyqxmd.com/read/25967873/effects-of-synthetic-neural-adhesion-molecule-mimetic-peptides-and-related-proteins-on-the-cardiomyogenic-differentiation-of-mouse-embryonic-stem-cells
#13
Ruodan Xu, Sureshkumar Perumal Srinivasan, Poornima Sureshkumar, Erastus Nembu Nembo, Christoph Schäfer, Judith Semmler, Matthias Matzkies, Morten Albrechtsen, Jürgen Hescheler, Filomain Nguemo
BACKGROUND/AIMS: Pluripotent stem cells differentiating into cardiomyocyte-like cells in an appropriate cellular environment have attracted significant attention, given the potential use of such cells for regenerative medicine. However, the precise mechanisms of lineage specification of pluripotent stem cells are still largely to be explored. Identifying the role of various small synthetic peptides involved in cardiomyogenesis may provide new insights into pathways promoting cardiomyogenesis...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/25955764/deletion-of-fibrinogen-like-protein-2-fgl-2-a-novel-cd4-cd25-treg-effector-molecule-leads-to-improved-control-of-echinococcus-multilocularis-infection-in-mice
#14
Junhua Wang, Dominique A Vuitton, Norbert Müller, Andrew Hemphill, Markus Spiliotis, Oleg Blagosklonov, Denis Grandgirard, Stephen L Leib, Itay Shalev, Gary Levy, Xiaomei Lu, Renyong Lin, Hao Wen, Bruno Gottstein
BACKGROUND: The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. We previously showed that Fibrinogen-like-protein 2 (FGL2), a novel CD4+CD25+ Treg effector molecule, was over-expressed in the liver of mice experimentally infected with E. multilocularis. However, little is known about its contribution to the control of this chronic helminth infection...
May 2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25921036/comparative-analysis-of-first-year-fingolimod-and-natalizumab-drug-discontinuation-among-swedish-patients-with-multiple-sclerosis
#15
COMPARATIVE STUDY
T Frisell, L Forsberg, N Nordin, C Kiesel, L Alfredsson, J Askling, J Hillert, T Olsson, F Piehl
BACKGROUND: Natalizumab (NTZ) and fingolimod (FGL) are mainly used second line in relapsing-remitting multiple sclerosis (MS), although pivotal trials included mainly treatment-naïve patients. OBJECTIVE: This study aims to provide real-world data on safety and discontinuation rates. METHODS: Using IMSE, a drug monitoring registry for all newer MS drugs in Sweden, we analysed differences in baseline characteristics and 1-year drug survival for patients registered 2011-2013, initiating treatment with NTZ (n=640) or FGL (n=876)...
January 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/25868615/effects-of-dietary-supplementation-with-fermented-ginkgo-leaves-on-antioxidant-capacity-intestinal-morphology-and-microbial-ecology-in-broiler-chicks
#16
X H Zhang, Z Y Sun, F L Cao, H Ahmad, X H Yang, L G Zhao, T Wang
1. The purpose of this study was to evaluate the effects of supplementing diets with three types of fermented Ginkgo-leaves (FGL) on growth, antioxidant capacity, intestinal morphology and microbial ecology in broiler chicks. 2. A total of 300 d-old broilers were randomly allocated to 4 dietary treatments with 6 replications of 10 birds each. Birds were fed on basal diets (Control) or basal diets supplemented with 0.5% FGL with Candida utilis (CF group), Aspergillus niger (AF group) or their combined fermentation (CAF group), respectively, for a 42 d feeding trial...
2015: British Poultry Science
https://www.readbyqxmd.com/read/25496996/the-cell-membrane-prothrombinase-fibrinogen-like-protein-2-promotes-angiogenesis-and-tumor-development
#17
Esther Rabizadeh, Izhack Cherny, Doron Lederfein, Shany Sherman, Natalia Binkovsky, Yevgenia Rosenblat, Aida Inbal
The aim of the study was to further investigate the role of fibrinogen-like protein 2 (FGL-2), a transmembrane prothrombinase that directly cleaves prothrombin to thrombin, in angiogenesis and tumor development and the mechanism(s) underlying these processes. To study angiogenesis HUVEC clones with decreased fgl-2 mRNA were generated by specific siRNA. To study tumorigenesis SCID mice were implanted with intact (wild type) and fgl-2-silenced PC-3 clones. IFN-γ treated HUVEC expressing increased fgl-2 mRNA exhibited significant capillary sprouting that was not inhibited by hirudin, whereas fgl-2 silencing completely inhibited blood-vessel formation...
July 2015: Thrombosis Research
https://www.readbyqxmd.com/read/25491970/fgl-functionalized-self-assembling-nanofiber-hydrogel-as-a-scaffold-for-spinal-cord-derived-neural-stem-cells
#18
Jian Wang, Jin Zheng, Qixin Zheng, Yongchao Wu, Bin Wu, Shuai Huang, Weizhi Fang, Xiaodong Guo
A class of designed self-assembling peptide nanofiber scaffolds has been shown to be a good biomimetic material in tissue engineering. Here, we specifically made a new peptide hydrogel scaffold FGLmx by mixing the pure RADA16 and designer functional peptide RADA16-FGL solution, and we analyzed the physiochemical properties of each peptide with atomic force microscopy (AFM) and circular dichroism (CD). In addition, we examined the biocompatibility and bioactivity of FGLmx as well as RADA16 scaffold on spinal cord-derived neural stem cells (SC-NSCs) isolated from neonatal rats...
January 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/25303152/increased-activity-of-cell-membrane-associated-prothrombinase-fibrinogen-like-protein-2-in-peripheral-blood-mononuclear-cells-of-b-cell-lymphoma-patients
#19
Esther Rabizadeh, Izhack Cherny, Ofir Wolach, Shany Sherman, Natalia Binkovski, Alon Peretz, Doron Lederfein, Aida Inbal
Fibrinogen-like protein 2, FGL-2, was reported to be overexpressed in various cancer tissues, where it acts as a transmembrane prothrombinase. This study aims to determine the prothrombinase activity of FGL-2 in peripheral blood mononuclear cells (PBMC) of patients with B-cell lymphoma. FGL-2 activity was determined in patients with B-cell lymphoma (n = 53), and healthy controls (n = 145). FGL-2 activity in patients at diagnosis increased 3 ± 0.3 fold (p < 0.001). Sensitivity and specificity of the test was established at 73...
2014: PloS One
https://www.readbyqxmd.com/read/25218044/mode-of-action-of-allatostatins-in-the-regulation-of-juvenile-hormone-biosynthesis-in-the-cockroach-diploptera-punctata
#20
Juan Huang, Elisabeth Marchal, Ekaterina F Hult, Sven Zels, Jozef Vanden Broeck, Stephen S Tobe
The FGLamide allatostatins (FGL/ASTs) are a family of neuropeptides with pleiotropic functions, including the inhibition of juvenile hormone (JH) biosynthesis, vitellogenesis and muscle contraction. In the cockroach, Diploptera punctata, thirteen FGLa/ASTs and one allatostatin receptor (AstR) have been identified. However, the mode of action of ASTs in regulation of JH biosynthesis remains unclear. Here, we determined the tissue distribution of Dippu-AstR. And we expressed Dippu-AstR in vertebrate cell lines, and activated the receptor with the Dippu-ASTs...
November 2014: Insect Biochemistry and Molecular Biology
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