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Vmat nodes "breast cancer"

Alba Fiorentino, Umberto Tebano, Ruggero Ruggieri, Francesco Ricchetti, Filippo Alongi
AIM: For simultaneous bilateral breast cancer (SBBC) treatment, conventional radiotherapy (RT) has a number of critical shortcomings. Thus, the usefulness of volumetric arc therapy (VMAT) for SBBC is undeniable. CASE REPORT: A 34-year-old woman with SBBC received neoadjuvant chemotherapy followed by breast-conserving surgery and bilateral lymph node dissection. Given the conservative surgery and the nodal involvement after neoadjuvant chemotherapy, bilateral adjuvant RT to the breasts and regional nodes with doses of 50 Gy in 25 fractions and a simultaneous integrated boost (SIB) of 60 Gy to the surgical bed was proposed...
September 27, 2016: Tumori
Olivier Lauche, Youlia M Kirova, Pascal Fenoglietto, Emilie Costa, Claire Lemanski, Celine Bourgier, Olivier Riou, David Tiberi, Francois Campana, Alain Fourquet, David Azria
AIM: To analyse clinical and dosimetric results of helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT) in complex adjuvant breast and nodes irradiation. METHODS: Seventy-three patients were included (31 HT and 42 VMAT). Dose were 63.8 Gy (HT) and 63.2 Gy (VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes (SCN) and internal mammary chain (IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions...
August 28, 2016: World Journal of Radiology
Yi-Jun Kim, Kyubo Kim, Rena Lee, Jiyoung Kim, Wonguen Jung, Nam-Sun Paik, Byung-In Moon, Woosung Lim, Jihae Lee
BACKGROUND/AIM: We evaluated dosimetric and clinical results of volumetric-modulated arc therapy (VMAT) treating internal mammary nodes (IMNs) in patients with locally advanced breast cancer. PATIENTS AND METHODS: Between July 2012 and December 2013, treatment outcomes of 31 patients with stage III breast cancer treated with postoperative radiotherapy including the IMN field using VMAT were analyzed. RESULTS: The median follow-up was 25.2 months...
September 2016: Anticancer Research
Maria Carmen De Santis, Francesca Bonfantini, Michela Dispinzieri, Silvia Meroni, Barbara Diletto, Elisa D Mantero, Marzia Franceschini, Fulvia Soncini, Serena Di Cosimo, Vito Cosentino, Emanuele Pignoli, Laura Lozza
PURPOSE: To evaluate the dosimetric coverage of axillary levels I, II, and III obtained with standard whole breast irradiation in 1 to 2 positive sentinel lymph nodes (SLNs) patients not submitted to axillary lymph nodes dissection (ALND), and to compare the lymph nodes areas coverage obtained with 3D conformal radiation therapy, intensity-modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT). METHODS: Patients with 1 to 2 positive SLNs undergoing breast-conserving therapy, without ALND, were included in the analysis...
August 3, 2016: Tumori
Jan Seppälä, Janne Heikkilä, Kimmo Myllyoja, Kristiina Koskela
PURPOSE: The treatment planning of bilateral breast irradiation (BBI) is a challenging task. The overlapping of tangential fields is usually unavoidable without compromising the target coverage. The purpose of this study was to investigate the technical feasibility and benefits of a single isocentre volumetric modulated arc therapy (VMAT) in BBI. METHODS AND MATERIALS: Two women with bilateral breast cancer were included in this case study. The first patient (Pat#1) underwent a bilateral breast-conserving surgery and sentinel lymph node biopsy...
September 2015: Reports of Practical Oncology and Radiotherapy
Marguerite Tyran, Hugues Mailleux, Agnes Tallet, Pierre Fau, Laurence Gonzague, Mathieu Minsat, Laurence Moureau-Zabotto, Michel Resbeut
We compared two intensity-modulated radiotherapy techniques for left-sided breast treatment, involving lymph node irradiation including the internal mammary chain. Inverse planned arc-therapy (VMAT) was compared with a forward-planned multi-segment technique with a mono-isocenter (MONOISO). Ten files were planned per technique, delivering a 50-Gy dose to the breast and 46.95 Gy to nodes, within 25 fractions. Comparative endpoints were planning target volume (PTV) coverage, dose to surrounding structures, and treatment delivery time...
November 2015: Journal of Radiation Research
Andrea Riccardo Filippi, Riccardo Ragona, Cristina Piva, Davide Scafa, Christian Fiandra, Marco Fusella, Francesca Romana Giglioli, Frank Lohr, Umberto Ricardi
PURPOSE: The purpose of this study was to evaluate the risks of second cancers and cardiovascular diseases associated with an optimized volumetric modulated arc therapy (VMAT) planning solution in a selected cohort of stage I/II Hodgkin lymphoma (HL) patients treated with either involved-node or involved-site radiation therapy in comparison with 3-dimensional conformal radiation therapy (3D-CRT). METHODS AND MATERIALS: Thirty-eight patients (13 males and 25 females) were included...
May 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Qian Zhang, Xiao Li Yu, Wei Gang Hu, Jia Yi Chen, Jia Zhou Wang, Jin Song Ye, Xiao Mao Guo
BACKGROUND: The aim of the study was to evaluate the dosimetric benefit of applying volumetric modulated arc therapy (VMAT) on the post-mastectomy left-sided breast cancer patients, with the involvement of internal mammary nodes (IMN). PATIENTS AND METHODS: The prescription dose was 50 Gy delivered in 25 fractions, and the clinical target volume included the left chest wall (CW) and IMN. VMAT plans were created and compared with intensity-modulated radiotherapy (IMRT) plans on Pinnacle treatment planning system...
March 2015: Radiology and Oncology
Sonya Sergieva, Iglika Mihaylova, Elena Alexandrova, Milena Dimcheva, Luigi Mansi
The aim of modern intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) is to define the target areas including the smallest non-invaded margins, thus reducing the radiation dose to radiosensitive organs. To reach this goal, these methods require a more precise target delineation by imaging to better define the viable part of the tumor. Image-guided selection and demarcation of Gross Tumor Volume (GTV), Clinical Target Volume (CTV) and Organs at Risk (OAR) are the main steps to reach a satisfactory radiation treatment plan...
2015: Current Radiopharmaceuticals
Shanmugam Thirumalai Swamy, Chandrasekaran Anu Radha, Murugesan Kathirvel, Gandhi Arun, Shanmuga Subramanian
BACKGROUND: The purpose of this study was to assess the feasibility of deep inspiration breath-hold (DIBH) based volumetric modulated arc therapy (VMAT) for locally advanced left sided breast cancer patients undergoing radical mastectomy. DIBH immobilizes the tumor bed providing dosimetric benefits over free breathing (FB). MATERIALS AND METHODS: Ten left sided post mastectomy patients were immobilized in a supine position with both the arms lifted above the head on a hemi-body vaclock...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
X Sharon Qi, Tian X Liu, Arthur K Liu, Francis Newman, Rachel Rabinovitch, Brian Kavanagh, Y Angie Hu
The 3-dimensional conformal radiotherapy (3DCRT) technique is the standard for breast cancer radiotherapy. During treatment planning, not only the coverage of the planning target volume (PTV) but also the minimization of the dose to critical structures, such as the lung, heart, and contralateral breast tissue, need to be considered. Because of the complexity and variations of patient anatomy, more advanced radiotherapy techniques are sometimes desired to better meet the planning goals. In this study, we evaluated external-beam radiation treatment techniques for left breast cancer using various delivery platforms: fixed-field including TomoDirect (TD), static intensity-modulated radiotherapy (sIMRT), and rotational radiotherapy including Elekta volumetric-modulated arc therapy (VMAT) and tomotherapy helical (TH)...
2014: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Sarah O S Osman, Sandra Hol, Philip M Poortmans, Marion Essers
PURPOSE: To investigate the effects of using volumetric modulated arc therapy (VMAT) and/or voluntary moderate deep inspiration breath-hold (vmDIBH) in the radiation therapy (RT) of left-sided breast cancer including the regional lymph nodes. MATERIALS AND METHODS: For 13 patients, four treatment combinations were compared; 3D-conformal RT (i.e., forward IMRT) in free-breathing 3D-CRT(FB), 3D-CRT(vmDIBH), 2 partial arcs VMAT(FB), and VMAT(vmDIBH). Prescribed dose was 42...
July 2014: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Marlies Pasler, Johannes Lutterbach, Mari Björnsgard, Ursula Reichmann, Susanne Bartelt, Dietmar Georg
PURPOSE: To investigate the plan quality of two different volumetric modulated arc therapy (VMAT) techniques for lymph node-positive left-sided breast cancer. METHODS: Two VMAT plans were generated for 10 lymph node-positive left-sided breast cancer patients: one plan using one single segment of a full rotation, typically an arc segment of 230° (1s-VMAT); and a second plan consisting of 2 small tangential arc segments of about 50° (2s-VMAT). For plan comparison, various dose and dose volume metrics (Dmean, D98%, D2% for target volumes, D2%, Dmean and Vx% for organs at risk (OAR)) were evaluated...
June 2015: Zeitschrift Für Medizinische Physik
Uwe Schneider, Marcin Sumila, Judith Robotka, Damien Weber, Günther Gruber
BACKGROUND: To estimate the risk of radiation induced second cancers after radiotherapy using deep-inspiration breath-hold (DI) technique with three-dimensional conformal (3DCRT) and volumetric arc therapy (VMAT) for patients with Hodgkin's lymphoma (HL). METHODS: Early-stage HL with mediastinal and supraclavicular involvement was studied using an Alderson phantom. A whole body CT was performed and all tissues were delineated. The clinical target volumes and planning target volumes (PTV) were determined according to the German Hodgkin study group guidelines...
2014: Radiation Oncology
H Badakhshi, D Kaul, J Nadobny, B Wille, J Sehouli, V Budach
OBJECTIVE: To test the feasibility of volumetric modulated arc therapy (VMAT) in breast cancer and to compare it with three-dimensional conformal radiotherapy (3D-CRT) as conventional tangential field radiotheraphy (conTFRT). METHODS: 12 patients (Stage I, 8: 6 left breast cancer and 2 right breast cancer; Stage II, 4: 2 on each side). Three plans were calculated for each case after breast-conserving surgery. Breast was treated with 50 Gy in four patients with supraclavicular lymph node inclusion, and in eight patients without the node inclusion...
December 2013: British Journal of Radiology
M V Maraldo, N P Brodin, M C Aznar, I R Vogelius, P Munck af Rosenschöld, P M Petersen, L Specht
BACKGROUND: Hodgkin lymphoma (HL) survivors have an increased morbidity and mortality from secondary cancers and cardiovascular disease (CD). We evaluate doses with involved node radiotherapy (INRT) delivered as 3D conformal radiotherapy (3D CRT), volumetric modulated arc therapy (VMAT), or proton therapy (PT), compared with the extensive Mantle Field (MF). PATIENTS AND METHODS: For 27 patients with early-stage, mediastinal HL, treated with chemotherapy and INRT delivered as 3D CRT (30 Gy), we simulated an MF (36 Gy), INRT-VMAT and INRT-PT (30 Gy)...
August 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
M Pasler, D Georg, S Bartelt, J Lutterbach
PURPOSE: The aim of the present work was to explore plan quality and dosimetric accuracy of intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for lymph node-positive left-sided breast cancer. METHODS: VMAT and IMRT plans were generated with the Pinnacle(3) V9.0 treatment planning system for 10 lymph node-positive left-sided breast cancer patients. VMAT plans were created using a single arc and IMRT was performed with 4 beams using 6, 10, and 15 MV photon energy, respectively...
May 2013: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Akira Sakumi, Kenshiro Shiraishi, Tsuyoshi Onoe, Kentaro Yamamoto, Akihiro Haga, Kiyoshi Yoda, Kuni Ohtomo, Keiichi Nakagawa
We have successfully created a single arc volumetric modulated arc therapy (VMAT) plan for treating post-surgical left breast/chest wall and regional nodes using Elekta multileaf collimator (MLC). Dose volume histograms (DVHs) were compared between the VMAT plans and conventional tangential beam plans using a field-in-field technique, leading to significant DVH advantages in the VMAT plans. The difference between Elekta VMAT and Varian RapidArc due to different MLC designs was discussed in terms of the number of arcs required to cover a large target, highlighting a single arc capability of Elekta VMAT for a large target volume which may be less sensitive to unexpected organ motion during dose delivery...
2012: Journal of Radiation Research
Carmen C Popescu, Ivo A Olivotto, Wayne A Beckham, Will Ansbacher, Sergei Zavgorodni, Richard Shaffer, Elaine S Wai, Karl Otto
PURPOSE: Volumetric modulated arc therapy (VMAT) is a novel extension of conventional intensity-modulated radiotherapy (cIMRT), in which an optimized three-dimensional dose distribution may be delivered in a single gantry rotation. VMAT is the predecessor to RapidArc (Varian Medical System). This study compared VMAT with cIMRT and with conventional modified wide-tangent (MWT) techniques for locoregional radiotherapy for left-sided breast cancer, including internal mammary nodes. METHODS AND MATERIALS: Therapy for 5 patients previously treated with 50 Gy/25 fractions using nine-field cIMRT was replanned with VMAT and MWT...
January 1, 2010: International Journal of Radiation Oncology, Biology, Physics
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