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https://www.readbyqxmd.com/read/29772394/antimicrobial-resistance-and-genetic-lineages-of-faecal-enterococci-of-wild-birds-emergence-of-vana-and-vanb2-harboring-enterococcus-faecalis
#1
Houssem Ben Yahia, Sarra Chairat, Nabil Hamdi, Haythem Gharsa, Rym Ben Sallem, Sara Ceballos, Carmen Torres, Karim Ben Slama
Migrating birds have been implicated in pathogen dissemination over long-distances. The lack of data on birds' intestinal microbiota makes these animals a promising path to understand their potential role in the transmission of antibiotic resistant bacteria. This work aims to study the diversity of enterococci species and to analyze the antimicrobial resistant phenotypes/genotypes, as well as the genetic lineages of isolates obtained from faecal and pellet samples of colonial wild birds in Tunisia. Seventy-nine enterococci were recovered of 150 wild bird, after inoculation of samples in Slanetz-Bartley agar, and were identified as E...
May 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29745166/-seasonal-changes-of-optical-absorption-properties-of-river-and-lake-in-east-liaohe-river-basin-northeast-china
#2
Yan Yan Song, Dong Hui Su, Tian Tian Shao
The absorption characteristics of optically active constituents (OACs) in water column are important optical properties and basic parameters of establishing the inverse analysis model. Comparative analyses about seasonal variability of the optical absorption characteristics (phytoplankton, non-algal particles and chromophoric dissolved organic matter absorption characteristics) and water quality status of East Liaohe River basin were conducted based on the water samples in Erlong-hu Reservoir collected in June, September and October of 2011 and samples in East Liaohe River in October of 2012...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29741998/serotype-and-antimicrobial-resistance-of-escherichia-coli-isolated-from-feces-of-wild-giant-pandas-ailuropoda-melanoleuca-in-sichuan-province-china
#3
Danyu Chen, Wencheng Zou, Shengze Xie, Linghan Kong, Yanpeng Chen, Xiuzhong Zhang, Jianan Li, Hongning Wang, Guangyang Cheng, Yue Qin, Xingyu Mu, Xin Yang
Escherichia coli is a major pathogen leading to systemic and enteric illnesses in wild giant pandas ( Ailuropoda melanoleuca). To investigate the characteristics and distribution of E. coli in wild giant pandas across four different nature reserves in Sichuan, Republic of China, we researched serotypes, phylogenetic groups, antimicrobial resistance, and resistance genes of E. coli not previously reported for wild giant pandas. A total of 82 E. coli isolates were identified from 40 fecal samples in August 2016 to May 2017...
May 9, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29735825/high-level-aminoglycoside-resistance-in-acinetobacter-baumannii-recovered-from-intensive-care-unit-patients-in-northeastern-india
#4
Supriya Upadhyay, Annie Bakorlin Khyriem, Prithwis Bhattacharya, Amitabha Bhattacharjee, Santa Ram Joshi
Background: Acinetobacter baumannii has emerged as an important nosocomial pathogen, its ability to acquire resistance to carbapenems and aminoglycosides, has complicated their treatment regimen. The present study investigates the prevalence and diversity of aminoglycoside-modifying enzymes and 16S methyltransferases in A. baumannii isolates recovered from patients admitted in Intensive Care Unit (ICU) of a tertiary referral hospital in Northeastern India. Materials and Methods: We investigated the high-level aminoglycoside-resistance (HLAR) (gentamicin and amikacin minimum inhibitory concentration ≥ 512 μg/ml) among 164 multidrug-resistant A...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29727265/prevalence-of-aminoglycoside-modifying-enzymes-in-escherichia-coli-and-klebsiella-pneumoniae-producing-extended-spectrum-%C3%AE-lactamases-collected-in-two-multicenter-studies-in-spain
#5
Marta Fernández-Martínez, Belén Ruiz Del Castillo, Maria Jesús Lecea-Cuello, Jesús Rodríguez-Baño, Álvaro Pascual, Luis Martínez-Martínez
The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated...
May 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708846/distribution-of-aminoglycoside-modifying-enzymes-and-molecular-analysis-of-the-coagulase-gene-in-clinical-isolates-of-methicillin-resistant-and-methicillin-susceptible-staphylococcus-aureus
#6
Farhad Seyedi-Marghaki, Davood Kalantar-Neyestanaki, Fereshteh Saffari, Hossein Hosseini-Nave, Mohammad Moradi
Enzymatic alteration of aminoglycosides by aminoglycoside-modifying enzymes (AMEs) is the major mechanism of resistance to aminoglycosides. The purpose of this study was to determine the frequency of AME genes, staphylococcal chromosomal cassette mec (SCCmec) types, and molecular analysis of the coagulase (coa) gene in Staphylococcus aureus strains isolated from clinical specimens. Totally, 102 S. aureus were tested by disk diffusion and microbroth dilution methods for susceptibility to aminoglycosides. AMEs genes and SCCmec types were determined by multiplex polymerase chain reaction (PCR)...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29687766/identification-and-prevalence-of-rnd-family-multidrug-efflux-pump-oqxab-genes-in-enterococci-isolates-from-swine-manure-in-china
#7
Li Yuan, Ya-Jun Zhai, Hua Wu, Hua-Run Sun, Zhi-Pei He, Ya-Bin Wang, Yu-Shan Pan, Nan-Nan Kuang, Gong-Zheng Hu
PURPOSE: The resistance/nodulation/cell division (RND) family multidrug efflux pump, OqxAB, has been identified as one of the leading mechanisms of plasmid-mediated quinolone resistance and has become increasingly prevalent among Enterobacteriaceae in recent years. However, oqxAB genes have not yet been reported in Enterococcus isolates. The aim of the present study was to identify the oqxAB genes and investigate their prevalence among Enterococcus from swine manure in China. METHODOLOGY: The oqxAB genes were screened in 87 Enterococcus isolates by PCR...
April 23, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29678910/serotype-diversity-and-antimicrobial-resistance-among-salmonella-enterica-isolated-from-patients-at-an-equine-referral-hospital
#8
I M Leon, S D Lawhon, K N Norman, D S Threadgill, N Ohta, J Vinasco, H M Scott
Although Salmonella enterica can produce life-threatening colitis in horses, certain serotypes are more commonly associated with clinical disease. Our aim was to evaluate the proportional morbidity attributed to different serotypes, as well as phenotypic and genotypic antimicrobial resistance (AMR) of Salmonella isolated from patients at an equine referral hospital in the southern United States. Two-hundred-fifty-five Salmonella isolates were obtained from clinical samples of patients admitted to the hospital between 2007 and 2015...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29676483/molecular-characteristics-of-antimicrobial-resistance-and-virulence-determinants-of-staphylococcus-aureus-isolates-derived-from-clinical-infection-and-food
#9
Kui Luo, Fuye Shao, Kadijatu N Kamara, Shuaiyin Chen, Rongguang Zhang, Guangcai Duan, Haiyan Yang
BACKGROUND: Staphylococcus aureus (S. aureus) is an important human etiologic agent. An investigation of the characteristics of common genotypes of S. aureus relating to pathogenicity and antibiotic resistance may provide a foundation to prevent infection. METHODS: This study collected 275 S. aureus isolates from Zhengzhou city in China, including 148 isolates from patient samples and 127 isolates from ready-to-eat food samples. Antimicrobial susceptibility testing was performed using the broth dilution method...
April 20, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29673307/the-pathology-of-wobbly-hedgehog-syndrome
#10
Josué Díaz-Delgado, Derick B Whitley, Ralph W Storts, Jill J Heatley, Sharman Hoppes, Brian F Porter
Wobbly hedgehog syndrome (WHS) is a leading cause of neurologic disease in African pygmy hedgehogs (APHs; Atelerix albiventris). This study describes the signalment, clinical signs, gross, microscopic, and ultrastructural lesions of WHS in a cohort of 12 pet APHs. Microscopically, lesions consisted of status spongiosus of the white matter, typically bilateral and symmetrical, with myelin degeneration and loss that was accompanied by neuronal/axonal degeneration plus reactive microgliosis and mild, focal astrocytosis and astrogliosis...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29668724/the-somatostatin-receptor-2-antagonist-64cu-nodaga-jr11-outperforms-64cu-dota-tate-in-a-mouse-xenograft-model
#11
Svetlana N Rylova, Christian Stoykow, Luigi Del Pozzo, Keelara Abiraj, Maria Luisa Tamma, Yvonne Kiefer, Melpomeni Fani, Helmut R Maecke
Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical applications. The aim of this study was to perform a side-by-side comparison of the in vitro and in vivo performance of 64Cu-NODAGA-JR11 (NODAGA = 1,4,7-triazacyclononane,1-glutaric acid,4,7-acetic acid, JR11 = p-Cl-Phe-cyclo(D-Cys-Aph(Hor)-D-Aph(cbm)-Lys-Thr-Cys)D-Tyr-NH2), a somatostatin receptor 2 antagonist, with the clinically used sst2 agonist 64Cu-DOTA-TATE ((TATE = D-Phe-cyclo(Cys-Tyr-D-Trp-Lys-Thr-Cys)Thr). In vitro studies demonstrated Kd values of 5...
2018: PloS One
https://www.readbyqxmd.com/read/29665444/ndm-1-and-oxa-23-producing-acinetobacter-baumannii-isolated-from-intensive-care-unit-patients-in-tunisia
#12
Elaa Maamar, Carla Andrea Alonso, Sana Ferjani, Ali Jendoubi, Zaineb Hamzaoui, Alia Jebri, Mabrouka Saidani, Salma Ghedira, Carmen Torres, Ilhem Boutiba-Ben Boubaker
Gastrointestinal colonization by carbapenem-resistant Acinetobacter baumannii (CRAB), is a critical step before nosocomial infection. Our objective was to evaluate CRAB intestinal carriage in patients admitted in the intensive care unit (ICU) of a Tunisian Hospital and to determine the antimicrobial resistance mechanisms involved. From December-2014 to February-2015, all 63 patients admitted at the ICU were screened for rectal CRAB-colonization upon admission and once weekly thereafter. ICU-patients who acquired a CRAB-nosocomial-infection were also included...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29661878/plasticity-of-aminoglycoside-binding-to-antibiotic-kinase-aph-2-ia
#13
Shane J Caldwell, Albert M Berghuis
APH(2")-Ia aminoglycoside resistance enzyme forms the C-terminal domain of the bifunctional AAC(6')-Ie/APH(2")-Ia enzyme and confers high-level resistance to natural 4,6-disubstituted aminoglycosides. In addition, reports have suggested that the enzyme can phosphorylate 4,5-disubstituted compounds and aminoglycosides with substitutions at the N1-position. Previously determined structures of the enzyme with aminoglycosides bound have not indicated how these non-canonical substrates could bind and be modified by the enzyme...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29629773/conformational-plasticity-in-tki-kinase-interactions-revealed-with-fluorescence-spectroscopy-and-theoretical-calculations
#14
Muhammad Khattab, Feng Wang, Andrew Harry A Clayton
To understand drug-protein dynamics, it is necessary to account for drug molecular flexibility and binding site plasticity. Herein, we exploit fluorescence from a tyrosine kinase inhibitor, AG1478, as a reporter of its conformation and binding-site environment when complexed with its cognate kinase. Water-soluble kinases, aminoglycoside phosphotransferase APH(3`)-Ia and mitogen activated protein kinase 14 (MAPK 14), were chosen for this study. Based on our prior work, the AG1478 conformation (planar or twisted) was inferred from the fluorescence excitation spectrum, the polarity of the AG1478 binding site was deduced from the fluorescence emission spectrum, while red-edge excitation shift (REES) probed the heterogeneity of the binding site (protein conformation and hydration) distributions in the protein conformational ensemble...
April 9, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29625607/asparagus-cochinchinensis-stimulates-release-of-nerve-growth-factor-and-abrogates-oxidative-stress-in-the-tg2576-model-for-alzheimer-s-disease
#15
Hyun Ah Lee, Ji Eun Kim, Ji Eun Sung, Woo Bin Yun, Dong Seob Kim, Hee Seob Lee, Jin Tae Hong, Dae Youn Hwang
BACKGROUD: Use of multifunctional drugs with neurotrophic supporting and oxidative stress suppressing activity may be considered a therapeutic strategy to protect or repair cellular damage caused during the progression of Alzheimer's disease (AD). In this study, we investigated the therapeutic effects of aqueous extract of A. cochinchinesis root (AEAC), particularly its role as a nerve growth factor (NGF) stimulator and anti-oxidant in Tg2576 mice showing AD phenotypes of human. METHODS: Tg2576 mice were received 100 mg/kg/day AEAC via oral administration, while mice in the Vehicle treated group received dH2 O for 4 weeks...
April 6, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29615891/catalpol-inhibits-amyloid-%C3%AE-generation-through-promoting-%C3%AE-cleavage-of-app-in-swedish-mutant-app-overexpressed-n2a-cells
#16
Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan-You Wang
Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer's disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD. The natural product catalpol, isolated from Rehmannia glutinosa , has shown neuroprotective activities through inhibiting soluble Aβ production, degrading Aβ peptide, and attenuating Aβ toxicity and neuroinflammatory responses. In the present study, we aimed to evaluate whether catalpol reduce Aβ generation associated with regulating amyloid precursor protein (APP) proteolytic processing...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29575062/restored-response-to-adp-downstream-of-purinergic-p2y-12-receptor-in-apheresis-platelets-after-pathogen-reducing-xenon-flash-treatment
#17
Hideki Abe, Takaaki Abe, Masayuki Shiba, Masahiro Satake
BACKGROUND: Our previous study revealed that pathogen-reducing filtered xenon flash-treated platelets (fXe-PLTs) showed sustained aggregation in response to adenosine diphosphate (ADP), but apheresis-collected PLTs (Aph-PLTs) showed reversible aggregation. STUDY DESIGN AND METHODS: Aph-PLTs, fXe-PLTs, and freshly prepared PLTs (PRP-PLTs) from whole blood were used to investigate the following responses to ADP: concentration response and effects of ADP receptor antagonists on aggregation, the cytosolic calcium (Ca2+ ) flux downstream of P2Y1 receptor signaling, and phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and signaling intermediate protein Akt downstream of the P2Y12 receptor...
March 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29570453/anencephaly-and-obstetric-outcome-beyond-the-age-of-viability
#18
Sawsan Al-Obaidly, Jis Thomas, Mahmoud Abu Jubara, Abdullah Al Ibrahim, Mariam Al-Belushi, Najah Saleh, Zeena Al-Mansouri, Najat Khenyab
OBJECTIVE: To review the obstetric impact and natural history of anencephalic pregnancies beyond the age of viability. STUDY DESIGN: A retrospective chart review of all cases with a prenatal diagnosis of anencephaly who delivered after 24 weeks' gestation during the period 1990 until 2016. Obstetric outcomes including mode of delivery, live births, shoulder dystocia, antepartum haemorrhage (APH), postpartum haemorrhage (PPH) and uterine rupture were studied. RESULTS: A total of 42 cases were studied...
March 23, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29526197/use-of-whole-genome-sequencing-for-campylobacter-surveillance-from-narms-retail-poultry-in-the-united-states-in-2015
#19
Chris A Whitehouse, Shenia Young, Cong Li, Chih-Hao Hsu, Gordon Martin, Shaohua Zhao
Whole genome sequencing (WGS) has become a rapid and affordable tool for public health surveillance and outbreak detection. In this study, we used the Illuminia MiSeq® to sequence 589 Campylobacter isolates obtained in 2015 from retail poultry meats as part of the National Antimicrobial Resistance Monitoring System (NARMS). WGS data were used to identify the Campylobacter species and to compare the concordance between resistance genotypes and phenotypes. WGS accurately identified 386 C. jejuni and 203 C. coli using gyrA sequence information...
August 2018: Food Microbiology
https://www.readbyqxmd.com/read/29515558/htlv-deregulation-of-the-nf-%C3%AE%C2%BAb-pathway-an-update-on-tax-and-antisense-proteins-role
#20
REVIEW
Stefania Fochi, Simona Mutascio, Umberto Bertazzoni, Donato Zipeto, Maria G Romanelli
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL), an aggressive CD4+ /CD25+ T-cell malignancy and of a severe neurodegenerative disease, HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The chronic activation or deregulation of the canonical and non-canonical nuclear factor kappa B (NF-κB) pathways play a crucial role in tumorigenesis. The HTLV-1 Tax-1 oncoprotein is a potent activator of the NF-κB transcription factors and the NF-κB response is required for promoting the development of HTLV-1 transformed cell lines...
2018: Frontiers in Microbiology
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