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https://www.readbyqxmd.com/read/27894951/a-pilot-study-of-cxcl8-levels-in-crystal-proven-gout-patients-during-allopurinol-treatment-and-their-association-with-cardiovascular-disease
#1
Laura Kienhorst, Hein Janssens, Tim Radstake, Piet van Riel, Hans Jacobs, Elly van Koolwijk, Ellen van Lochem, Matthijs Janssen
OBJECTIVES: Gout is associated with cardiovascular diseases, and systemic inflammation has a role in this. CXCL8 (interleukin 8) levels were increased in synovial fluid of gout patients, and in serum in gout patients irrespective of their disease activity. We hypothesized that the well-known cardiovascular protective effects of allopurinol could be related to effects of this drug on CXCL8 levels. METHODS: Patients with a crystal proven gout diagnosis, who newly started allopurinol treatment, were included in this prospective cohort study...
November 25, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27878500/anti-inflammatory-and-antioxidant-effect-of-kerabala-a-value-added-ayurvedic-formulation-from-virgin-coconut-oil-inhibits-pathogenesis-in-adjuvant-induced-arthritis
#2
M Ratheesh, S Sandya, C Pramod, S Asha, Jose P Svenia, S Premlal, B GrishKumar
Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-induced acute and adjuvant-induced chronic experimental models. 5 mg/kg bwt was found to be potent dose from carrageenan model and evaluated its effect in adjuvant-induced chronic arthritic model...
November 22, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27852377/-predictive-value-of-dynamic-enhanced-mr-synovial-wash-in-rate-in-progression-to-rheumatoid-arthritis-in-patients-with-undifferentiated-arthritis
#3
H X Li, J Qu, Y Zhan, X W Lei
Objective: To investigate the predictive value of dynamic enhanced MR synovial wash in rate (WASHIN) in progression to rheumatoid arthritis (RA) in patients with undifferentiated arthritis (UA). Methods: The data of dynamic enhanced MR synovial WASHIN and C- reactive protein (CRP) of 33 patients with UA were analyzed between October 2014 and January 2016 from Tianjin First Center Hospital, so as to evaluate the correlation between the two indicators. According to the value of CRP, the patients were divided into two groups, the CRP>8 mg/L for CRP positive group (18 cases), CRP≤8 mg/L for CRP negative group (15 cases)...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27832086/serum-calprotectin-discriminates-subclinical-disease-activity-from-ultrasound-defined-remission-in-patients-with-rheumatoid-arthritis-in-clinical-remission
#4
Jana Hurnakova, Hana Hulejova, Jakub Zavada, Martin Komarc, Petra Hanova, Martin Klein, Herman Mann, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt
OBJECTIVE: Clinical remission in some patients with rheumatoid arthritis (RA) may be associated with ongoing synovial inflammation that is not always detectable on clinical examination or reflected by laboratory tests but can be visualized by musculoskeletal ultrasound. The goal of our study was to determine the levels of serum calprotectin, a major leukocyte protein, in patients with RA in clinical remission and to investigate the ability of serum calprotectin levels to distinguish patients in ultrasound-defined remission from those with residual ultrasound subclinical inflammation...
2016: PloS One
https://www.readbyqxmd.com/read/27826220/chitinase-3-like-1-is-produced-by-human-th17-cells-and-correlates-with-the-level-of-inflammation-in-juvenile-idiopathic-arthritis-patients
#5
Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato, Lorenzo Cosmi
BACKGROUND: CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that chitinases are important in inflammatory processes and tissue remodeling, but their production by human T cells, has never been reported. METHODS: A microarray analysis of gene expression profile was performed on Th17 and classic Th1 cell clones and CHI3L1 was found among the up-regulated genes on Th17 cells...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27793205/measurement-of-serum-c-reactive-protein-concentration-for-discriminating-between-suppurative-arthritis-and-osteoarthritis-in-dogs
#6
Anna Hillström, Jonas Bylin, Ragnvi Hagman, Karin Björhall, Harold Tvedten, Kristian Königsson, Tove Fall, Mads Kjelgaard-Hansen
BACKGROUND: In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations...
October 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27784336/a-proof-of-concept-study-with-the-tyrosine-kinase-inhibitor-nilotinib-in-spondyloarthritis
#7
Jacqueline E Paramarta, Maureen C Turina, Troy Noordenbos, Tanja F Heijda, Iris C Blijdorp, Nataliya Yeremenko, Dominique Baeten
BACKGROUND: To evaluate the immunomodulating and clinical effects of nilotinib, a tyrosine kinase inhibitor, in a proof-of-concept study in spondyloarthritis (SpA) assessing the mast cell as potential novel therapeutic target in this disease. METHODS: Twenty eight patients with active peripheral (pSpA) and/or axial SpA (axSpA) were included in a randomized, double-blind, placebo-controlled clinical trial (Trial registration: Trialregister.nl NTR2834). Patients were treated 1:1 with nilotinib or placebo for 12 weeks, followed by an open label extension for another 12 weeks...
October 27, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27763638/1-25-dihydroxy-vitamin-d3-with-tumor-necrosis-factor-alpha-protects-against-rheumatoid-arthritis-by-promoting-p53-acetylation-mediated-apoptosis-via-sirt1-in-synoviocytes
#8
Xin Gu, Bingjie Gu, Xianhui Lv, Zhenzhen Yu, Rong Wang, Xiaoli Zhou, Wanxin Qiao, Zhiyuan Mao, Guoping Zuo, Qing Li, Dengshun Miao, Jianliang Jin
Impaired apoptosis of fibroblast-like synoviocytes (FLSs) causes synovial hyperplasia, facilitating destruction of cartilage and bone in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α, a dominant inflammatory mediator in RA pathogenesis, promotes progression of RA symptoms. Prevalence of 1, 25-dihydroxy-vitamin D3 (hereafter termed VD) deficiency is 30-63% in patients with RA. Whether VD leads to apoptosis or enhances TNF-α-mediated apoptosis in FLSs to ameliorate RA is unclear. To determine this, 10-week-old CYP27B1-deficient (CYP27B1(-/-)) mice with collagen-induced arthritis (CIA) were intraperitoneally treated with 1 μg/kg VD every other day for 9 weeks...
October 20, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27747452/sesame-oil-and-rice-bran-oil-ameliorates-adjuvant-induced-arthritis-in-rats-distinguishing-the-role-of-minor-components-and-fatty-acids
#9
Nayana Venugopal Yadav, Sadashivaiah, Breetha Ramaiyan, Pooja Acharya, Lokesh Belur, Ramaprasad Ravichandra Talahalli
Though present in small amounts, the minor constituents of dietary oils may supplement the dietary therapies for rheumatoid arthritis (RA). Hence, in the present study, we assessed the effect of minor constituents from sesame oil (SO) and rice bran oil (RBO) and their fatty acids on the severity of adjuvant-induced arthritis in experimental rats. Rats were gavaged with 1 mL of SO or RBO or groundnut oil (GNO, control) with or without its minor components for a period 15 days before and 15 days after the induction of arthritis...
October 17, 2016: Lipids
https://www.readbyqxmd.com/read/27720413/neer-award-2015-analysis-of-cytokine-profiles-in-the-diagnosis-of-periprosthetic-joint-infections-of-the-shoulder
#10
Salvatore J Frangiamore, Anas Saleh, Matthew J Grosso, Mario Farias Kovac, Xiaochun Zhang, Thomas M Daly, Thomas W Bauer, Kathleen A Derwin, Joseph P Iannotti, Eric T Ricchetti
BACKGROUND: Periprosthetic joint infection (PJI) after shoulder arthroplasty can present a diagnostic and therapeutic challenge. This study evaluated the diagnostic utility of broader synovial fluid cytokine analysis for identifying PJI in patients undergoing revision shoulder arthroplasty. METHODS: Synovial fluid levels of 9 cytokines (interleukin [IL] 6, granulocyte-macrophage colony-stimulating factor, IL-1β, IL-12, IL-2, IL-8, interferon-γ, IL-10, and tumor necrosis factor-α) were measured in 75 cases of revision shoulder arthroplasty with a multiplex immunoassay...
October 5, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27694589/the-diagnostic-thresholds-for-synovial-fluid-analysis-in-late-periprosthetic-infection-of-the-hip-depend-on-the-duration-of-symptoms
#11
H-R Choi, K Agrawal, H Bedair
AIMS: We hypothesised that the synovial white blood cell (WBC) count in patients with a late periprosthetic joint infection (PJI) of the hip would depend on the duration of a patient's symptoms, and that the optimal diagnostic threshold would also depend on this period of time. PATIENTS AND METHODS: The synovial WBC count and percentage of polymorphonuclear cells (%PMN), and the serum CRP and ESR levels obtained > six weeks after primary THA were compared between 50 infected and 88 non-infected THAs, and in patients with symptoms for more than or less than two weeks...
October 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27692392/a-new-musculoskeletal-ultrasound-scoring-system-us10-of-the-hands-and-wrist-joints-for-evaluation-of-early-rheumatoid-arthritis-patients
#12
Karine R Luz, Marcelo M Pinheiro, Giovanna S Petterle, Marla F Dos Santos, Artur R C Fernandes, Jamil Natour, Rita N V Furtado
OBJECTIVE: To propose a novel ultrasound scoring system for hand and wrist joints (US10) for evaluation of patients with early rheumatoid arthritis (RA) and to correlate the US10 with clinical, laboratory and functional variables. METHODS: Forty-eight early RA patients underwent clinical and laboratory evaluations as well as blinded ultrasound (US) examinations at baseline, three, six and 12 months. The proposed US10 system involved the assessment of the wrist, second and third metacarpophalangeal and proximal interphalangeal joints...
September 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27688601/prospective-clinical-trial-for-septic-arthritis-cartilage-degradation-and-inflammation-are-associated-with-upregulation-of-cartilage-metabolites
#13
Hagen Schmal, Anke Bernstein, Matthias J Feucht, Benjamin Erdle, Jan M Pestka, That Minh Pham, Eva Johanna Kubosch
Background. Intra-articular infections can rapidly lead to osteoarthritic degradation. The aim of this clinical biomarker analysis was to investigate the influence of inflammation on cartilage destruction and metabolism. Methods. Patients with acute joint infections were enrolled in a prospective clinical trial and the cytokine composition of effusions (n = 76) was analyzed. Characteristics of epidemiology and disease severity were correlated with levels of cytokines with known roles in cartilage turnover and degradation...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27687651/-correlation-of-dnase-i-in-serum-and-synovial-fluid-with-inflammatory-activity-in-patients-with-rheumatoid-arthritis
#14
Xia-Yu Xu, Wen-Fang Yang, Si-Gong Zhang, Qin Zhao, Li-Jun Linag, Xin Wang, Hai-Li Shen
OBJECTIVE: To investigate the potential role of deoxyribonuclease I (DNase I) in the pathogenesis of rheumatoid arthritis (RA). METHODS: DNase I activity was measured by radial enzyme-diffusion method in serum samples from 83 RA patients and 60 healthy volunteers and in the synovial fluid (SF) from 27 RA patients and 38 patients with other inflammatory arthritis. SF cfDNA level was measured with Pico Green Kit, and the correlation among DNase I activity, cfDNA level and clinical parameters of RA patients was analyzed...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27672013/what-is-the-diagnostic-accuracy-of-aspirations-performed-on-hips-with-antibiotic-cement-spacers
#15
Jared M Newman, Jaiben George, Alison K Klika, Stephen F Hatem, Wael K Barsoum, W Trevor North, Carlos A Higuera
BACKGROUND: Periprosthetic joint infection is a serious complication after THA and commonly is treated with a two-stage revision. Antibiotic-eluting cement spacers are placed for local delivery of antibiotics. Aspirations may be performed before the second-stage reimplantation for identification of persistent infection. However, limited data exist regarding the diagnostic parameters of synovial fluid aspiration with or without saline lavage from a hip with an antibiotic-loaded cement spacer...
September 26, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27637855/eka-survey-diagnosis-of-prosthetic-knee-joint-infection
#16
Sufian S Ahmad, Roland Becker, Antonia F Chen, Sandro Kohl
PURPOSE: Due to the juvenility of research in the field of periprosthetic joint infection (PJI), approaches employed for diagnosis of PJI vary amongst surgeons in different geographic regions. The aim of this study was to determine common diagnostic approaches utilized by European knee arthroplasty surgeons for the diagnosis of PJI. METHODS: A task force was established for questionnaire development, consisting of surgeons and clinical researchers who each had a record of publishing in the field of PJI...
October 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27629533/synovial-fluid-adipokines-are-associated-with-clinical-severity-in-knee-osteoarthritis-a-cross-sectional-study-in-female-patients-with-joint-effusion
#17
Joan Calvet, Cristóbal Orellana, Jordi Gratacós, Antoni Berenguer-Llergo, Assumpta Caixàs, Juan José Chillarón, Juan Pedro-Botet, María García-Manrique, Noemí Navarro, Marta Larrosa
BACKGROUND: Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. METHODS: Cross-sectional study with systematic inclusion of female patients with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, physical exercise, knee osteoarthritis symptoms duration, classical cardiovascular risk factors and different anthropometric measurements were collected...
September 15, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27609563/aspergillus-arthritis-analysis-of-clinical-manifestations-diagnosis-and-treatment-of-31-reported-cases
#18
Maria N Gamaletsou, Blandine Rammaert, Marimelle A Bueno, Nikolaos V Sipsas, Brad Moriyama, Dimitrios P Kontoyiannis, Emmanuel Roilides, Valerie Zeller, Saad J Taj-Aldeen, Michael Henry, Vidmantas Petraitis, David W Denning, Olivier Lortholary, Thomas J Walsh
Aspergillus arthritis is a debilitating form of invasive aspergillosis. Little is known about its epidemiology, clinical manifestations, laboratory features, treatment, and prognosis. Cases of Aspergillus arthritis were reviewed in the English literature from 1967 through 2015 for variables of arthritis with Aspergillus spp. recovered from joint and/or adjacent bone, underlying conditions, symptoms, signs, inflammatory biomarkers, diagnostic imaging, management, and outcome. Among 31 evaluable cases, 87% were males and 13% pediatric...
September 8, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27575050/autologous-bone-marrow-derived-mesenchymal-stem-cells-modulate-molecular-markers-of-inflammation-in-dogs-with-cruciate-ligament-rupture
#19
Peter Muir, Eric C Hans, Molly Racette, Nicola Volstad, Susannah J Sample, Caitlin Heaton, Gerianne Holzman, Susan L Schaefer, Debra D Bloom, Jason A Bleedorn, Zhengling Hao, Ermias Amene, M Suresh, Peiman Hematti
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR...
2016: PloS One
https://www.readbyqxmd.com/read/27573797/sonography-is-superior-to-serum-based-biomarkers-for-measuring-disease-status-in-experimental-rheumatoid-arthritis
#20
Shuqiang Chen, Qing Zheng, Hui Liu, Jinshu Zeng, Zhen Ye, Yiming Su, Guorong Lv
OBJECTIVES: Progress in developing novel rational treatments for rheumatoid arthritis (RA) critically depends on preclinical work in experimental animals. However, there is lack of insight into the most appropriate mode of noninvasive measurement of disease status in experimental RA. This study compared sonography with serum biomarkers in a rabbit model of RA. METHODS: Six-month-old male New Zealand White rabbits were randomized into 2 groups: antigen-induced arthritis group (n = 25), which was subjected to ovalbumin immunization and intra-articular injection; and control group (n = 5)...
October 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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