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https://www.readbyqxmd.com/read/29104376/anti-tnf-alpha-adalimumab-therapy-had-time-lag-of-improvement-in-synovial-hypertrophy-compared-to-rapid-response-in-power-doppler-synovial-vascularity
#1
Ying-Chou Chen, Chi-Hua Ko, Jia-Feng Chen, Chung-Yuan Hsu, Wen-Chan Chiu, Tien-Tsai Cheng
Objectives: The quantification of synovitis is of great significance for follow-up in patients with rheumatoid arthritis (RA). This study aimed to validate the use of power Doppler ultrasonography (PDUS) for evaluating synovial vascularity and synovial hypertrophy for synovitis in patients with rheumatoid arthritis treated with adalimumab. Materials and Methods: The synovial disease activity and vascularity of RA on both wrists (radio-carpal joint) were assessed using GS and PDUS to derive the composite US scores based on abnormal counts and severity...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29096980/arthroscopic-management-of-septic-arthritis-of-the-native-shoulder-a-systematic-review
#2
REVIEW
Muzammil Memon, Jeffrey Kay, Lydia Ginsberg, Darren de Sa, Nicole Simunovic, Kristian Samuelsson, George S Athwal, Olufemi R Ayeni
PURPOSE: To investigate arthroscopic management of native shoulder joint septic arthritis-specifically, indications, patient outcomes, and complications. METHODS: PubMed, MEDLINE, and Embase were used to search the literature, and data abstraction was performed independently and in duplicate. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist guided reporting and data abstraction. The quality of all included studies was assessed with the Methodological Index for Non-randomized Studies (MINORS) criteria...
October 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29059113/the-diagnostic-utility-of-synovial-fluid-markers-in-periprosthetic-joint-infection-a-systematic-review-and-meta-analysis
#3
Anas Saleh, Deepak Ramanathan, Marcelo Bogliolo P Siqueira, Alison K Klika, Wael K Barsoum, Carlos A Higuera Rueda
INTRODUCTION: This study is a systematic review of all reported synovial fluid markers for the diagnosis of periprosthetic joint infection and a meta-analysis of the most frequently reported markers to identify those of greatest diagnostic utility. METHODS: A search of six databases was conducted to identify all studies evaluating the utility of synovial fluid markers in the diagnosis of periprosthetic joint infection. Two observers assessed methodologic quality and extracted data independently...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28988303/high-performance-of-%C3%AE-defensin-lateral-flow-assay-synovasure-in-the-diagnosis-of-chronic-knee-prosthetic-infections
#4
Giovanni Balato, Vincenzo Franceschini, Tiziana Ascione, Alfredo Lamberti, Michele D'Amato, Andrea Ensini, Andrea Baldini
PURPOSE: This prospective study was undertaken to evaluate the diagnostic accuracy of the Synovasure™ α-defensin lateral flow assay to detect or exclude infection and to compare it to the sensitivity and specificity of other diagnostic criteria according to the International Consensus Group on Periprosthetic Joint Infection (PJI). METHODS: All patients who have undergone revision total knee arthroplasty (TKA) from September 2015 to July 2016 were included: 16 chronic (more than 3 months after performing arthroplasty) infections and 35 aseptic joints were identified...
October 7, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28939030/positive-blood-cultures-in-periprosthetic-joint-infection-decrease-rate-of-treatment-success
#5
Mitchell R Klement, Ahmed Siddiqi, Justin M Rock, Antonia F Chen, Michael P Bolognesi, Thorsten M Seyler
BACKGROUND: Blood cultures are often obtained at the time of periprosthetic joint infection (PJI) diagnosis yet they are not considered part of the diagnostic criteria and the effects of a positive result on surgical outcome are unknown. The purposes of this study are to characterize the use of blood cultures when diagnosing PJI and to determine the association of positive blood cultures with PJI treatment success. METHODS: A retrospective chart review on 320 patients surgically treated for primary hip and knee PJIs was performed from 2006-2013 at 2 academic medical centers with minimum 12-month follow-up...
September 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#6
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28918785/-algorithm-for-workup-of-acute-swollen-knee-without-previous-trauma
#7
Jens Olesen, Finn Elkjær Johannsen
Acute non-traumatic swelling of the knee is a common clinical challenge. The reason for the swelling has to be explored in order to give the correct treatment. This article gives an overview of possible diagnoses and suggests an algorithm for an approach to non-traumatic knee arthritis. Fundamental in the examination is a thorough patient anamnesis, which will help to differentiate between inflammatory and non-inflammatory arthritis. If there is not an obvious degenerative reason for the knee effusion, a joint aspiration followed by synovial fluid white cell count (WCC), microscopy and/or culture will add valuable information...
September 18, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28912428/il-37-is-associated-with-osteoarthritis-disease-activity-and-suppresses-proinflammatory-cytokines-production-in-synovial-cells
#8
Liping Ding, Xiaoping Hong, Baodong Sun, Qin Huang, Xiaoqi Wang, Xiaokai Liu, Lingyun Li, Zhong Huang, Dongzhou Liu
The objective of this study is to investigate the correlation between IL-37 level and osteoarthritis activity and to determine the anti-inflammatory effects of IL-37 in peripheral blood mononuclear cells (PBMCs) and synovial cells (SCs) from osteoarthritis (OA) patients, which including 32 patients with erosive inflammatory OA (EIOA) and 40 patients with primary generalized OA (PGOA), 40 age and sex matched healthy volunteers were recruited as healthy controls (HCs). The protein and relative mRNA levels of IL-37 were significant increased in the blood of EIOA patients compared with those of PGOA patients and HCs...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901397/beneficial-effect-of-20%C3%A2-hydroxyecdysone-exerted-by-modulating-antioxidants-and-inflammatory-cytokine-levels-in-collagen%C3%A2-induced-arthritis-a-model-for-rheumatoid-arthritis
#9
You Sun, De-Li Zhao, Zi-Xuan Liu, Xue-Hui Sun, Yang Li
Rheumatoid arthritis is a chronic autoimmune disease characterized by an elevated synovial inflammatory response, with destruction or erosion of articular cartilage in major joints. The aim of the present study was to examine whether 20‑hydroxyecdysone (HES) is able to ameliorate oxidative stress and inflammatory responses in a collagen‑induced rheumatoid arthritis (CIA) rat model. A total of 40 healthy male rats were selected arbitrarily and separated into four groups. Rats treated with saline served as a control (group I), rats subjected to CIA induction by intradermal injection of bovine collagen II type served as the induced group (group II), while rats induced with CIA and administered with 10 and 20 mg/kg bodyweight HES for 28 days served as treatment groups (groups III and IV)...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28894708/hepatic-proteins-and-inflammatory-markers-in-rheumatoid-arthritis-patients
#10
Manel Ben-Hadj-Mohamed, Souhir Khelil, Mokhles Ben Dbibis, Latifa Khlifi, Hend Chahed, Salima Ferchichi, Elyes Bouajina, Abdelhédi Miled
BACKGROUND: Rheumatoid arthritis is an autoimmune inflammatory rheumatic disease that causes chronic synovial inflammation eventually leading to joint destruction and disability. The aim of this study was to determine the variations of hepatic proteins, myeloperoxidase, and iron in rheumatoid arthritis Tunisian patients and their implications in inflammation and in iron metabolism. METHODS: Overall, 172 patients from the Rheumatology Department of the University Hospital "Farhat Hached", Sousse-Tunisia between 2011 and 2012, with rheumatoid arthritis (97...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28875126/postoperative-deep-shoulder-infections-following-rotator-cuff-repair
#11
REVIEW
Kivanc Atesok, Peter MacDonald, Jeff Leiter, Sheila McRae, Greg Stranges, Jason Old
Rotator cuff repair (RCR) is one of the most commonly performed surgical procedures in orthopaedic surgery. The reported incidence of deep soft-tissue infections after RCR ranges between 0.3% and 1.9%. Deep shoulder infection after RCR appears uncommon, but the actual incidence may be higher as many cases may go unreported. Clinical presentation may include increasing shoulder pain and stiffness, high temperature, local erythema, swelling, warmth, and fibrinous exudate. Generalized fatigue and signs of sepsis may be present in severe cases...
August 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28871338/comparison-of-the-effectiveness-on-intra-articular-and-subcutaneous-tnf-inhibitor-in-rheumatoid-arthritis-patients
#12
Fangze Zhang, Cuili Ma
The objective of this study is to evaluate the efficacy of single intra-articular (IA) injection of tumor necrosis factor α (TNFα) inhibitor in knee joints comparing with subcutaneous injection in rheumatoid arthritis (RA) patients. Forty-eight RA patients with 73 knee arthritis were divided into three groups, group A: received a single injection of TNF inhibitor into knee joints; group B: received regular subcutaneous injection; and group C: received both of the regimen as groups A and B. Ultrasound, erythrocyte sedimentation rate, C-reactive protein (CRP), patients' global visual analogue scale (VAS), and 28-joint Disease Activity Score (DAS28) were collected pre- and post-therapy 4 weeks...
September 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28841913/accuracy-of-different-diagnostic-tests-for-early-delayed-and-late-prosthetic-joint-infection
#13
M Fernández-Sampedro, C Fariñas-Alvarez, C Garces-Zarzalejo, M A Alonso-Aguirre, C Salas-Venero, L Martínez-Martínez, M C Fariñas
BACKGROUND: A combination of laboratory, histopathological and microbiological tests for diagnosis of prosthetic joint infection (PJI) have been strongly recommended. This study aims to characterize the accuracy of individual or group tests, such as culture of sonicate fluid, synovial fluid and peri-implant tissue, C-reactive protein (CRP) and histopathology for detection of early, delayed and late PJI. METHODS: A prospective study of patients undergoing hip or knee arthroplasty from February 2009 to February 2014 was performed in a Spanish tertiary health care hospital...
August 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28826781/clitoria-ternatea-flower-petals-effect-on-tnfr1-neutralization-via-downregulation-of-synovial-matrix-metalloproteases
#14
Rana Adhikary, Sahin Sultana, Biswadev Bishayi
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea Linn. (C. ternatea) is a traditionally used herb in arthritis, and its anti-arthritic activity has been attributed to polyphenols (e.g. quercetins) from its flower petal. AIM OF THE STUDY: The present study was designed to investigate whether C. ternatea or quercetin-3ß-D-glucoside (QG) support the antibody mediated TNFα-receptor 1 (TNFR1) neutralization to ameliorate arthritis in mice. MATERIALS AND METHODS: Development of collagen-induced arthritis (CIA) in male Swiss mice (20-22g, 3-4 weeks of age) was followed by estimation of synovial polymorphonuclear cell (PMN) accumulation (in terms of myeloperoxidase activity), synovial and systemic release of cytokines, chemokines and C-reactive protein (CRP) by enzyme-linked immunosorbent assay (ELISA), biochemical estimation of synovial free radical generation and antioxidant status, as well as immunoblot assessment of synovial TNFR1, toll-like receptor 2(TLR2), cyclooxygenase-2(COX-2) and inducible nitric oxide synthase (iNOS) expression; and zymographic analysis of synovial matrix-metalloprotease-2 (MMP-2) activity...
August 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28804921/serum-thymidine-kinase-1-canine-c-reactive-protein-haptoglobin-and-vitamin-d-concentrations-in-dogs-with-immune-mediated-hemolytic-anemia-thrombocytopenia-and-polyarthropathy
#15
M Grobman, H Outi, H Rindt, C Reinero
BACKGROUND: Relapses of immune-mediated hemolytic anemia (IMHA), thrombocytopenia (ITP), or polyarthropathy (IMPA) occur despite normal hematologic and cytologic parameters. Thymidine kinase 1 (TK1), canine C-reactive protein (c-CRP), haptoglobin (HPT), and 25-Hydroxyvitamin-D (25(OH)D) might be adjunct to current monitoring strategies. HYPOTHESIS/OBJECTIVES: Compare serum concentrations of TK1, c-CRP, HPT, and 25(OH)D in dogs with well- and poorly controlled primary IMHA, ITP, or IMPA...
September 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28800858/diagnostic-value-of-synovial-white-blood-cell-count-and-serum-c-reactive-protein-for-acute-periprosthetic-joint-infection-after-knee-arthroplasty
#16
Sang-Gyun Kim, Jae-Gyoon Kim, Ki-Mo Jang, Seung-Bum Han, Hong-Chul Lim, Ji-Hoon Bae
BACKGROUND: The diagnosis of periprosthetic joint infection (PJI) remains difficult, particularly in acute postoperative stage. The purpose of this study was to investigate the optimal cutoff value of synovial white blood cell (WBC) count, percentage of polymorphonuclear cells, erythrocyte sedimentation rate, and C-reactive protein (CRP) for diagnosing early postoperative infection after knee joint arthroplasty. METHODS: We retrospectively reviewed primary total knee arthroplasties and unicompartmental knee arthroplasties, with a knee aspiration within 3 weeks of surgery, from January 2006 to November 2016...
July 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28762203/power-color-doppler-and-spectral-doppler-ultrasonography-to-evaluate-response-to-intra-articular-steroid-injection-in-knee-joints-in-juvenile-idiopathic-arthritis
#17
Tapas Baikar, Amieleena Chhabra, Tribhuvan Pal Yadav, Namrita Sachdev, Vivek Dewan
OBJECTIVE: To evaluate the role of ultrasonographic indices (Color Fraction and Resistive Index) in assessing the effect of intra-articular steroid (IAS) injection on synovial inflammation in knee joints of Juvenile Idiopathic Arthritis (JIA) patients and to determine the correlation between these ultrasonographic indices and clinical and laboratory parameters in JIA patients after IAS. METHODS: Twenty seven patients of JIA and equal number of age and sex matched healthy controls were enrolled...
November 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28740214/compensatory-anabolic-signaling-in-the-sarcopenia-of-experimental-chronic-arthritis
#18
Robert D Little, Iván Prieto-Potin, Sandra Pérez-Baos, Amanda Villalvilla, Paula Gratal, Flavia Cicuttini, Raquel Largo, Gabriel Herrero-Beaumont
Inflammatory activity in rheumatoid arthritis may alter the regulation of muscle mass leading to a secondary sarcopenia, commonly termed rheumatoid cachexia (RC). We characterized alterations to muscle structure and various pro-inflammatory, catabolic and regenerative markers in an animal model of RC. Antigen induced arthritis (AiA) was performed in 20 male adult rabbits. AiA animals exhibited significantly less weight gain, a markedly elevated serum C-reactive protein (CRP), lighter muscles with shorter cross-sectional diameter and increased myonuclei when compared to controls...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717843/septic-arthritis-associated-with-systemic-sepsis
#19
Sung-Weon Jung, Dong-Hee Kim, Sung-Jin Shin, Byoung-Youl Kang, Yil-Ju Eho, Seong-Wook Yang
PURPOSE: Septic arthritis presents with good joint function, but sometimes leads to poor outcomes. Concurrent systemic sepsis has been regarded as the poor outcome, and the exact cause remains unclear. This paper was performed to identify factors associated with concurrent systemic sepsis and to research results to predict poor outcomes in patients with septic arthritis. METHODS: Laboratory and medical data were reviewed for 137 adults with acute septic arthritis who underwent open or arthroscopic surgical debridement at our institution between January 2005 and December 2014...
July 17, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28712799/diagnosing-periprosthetic-joint-infection-and-the-winner-is
#20
Alisina Shahi, Timothy L Tan, Michael M Kheir, Dean D Tan, Javad Parvizi
BACKGROUND: Diagnosis of periprosthetic joint infection (PJI) remains a challenge despite a wide variety of available diagnostic tests. The question that arises is which of these tests has a better performance for diagnosing PJI. Diagnostic odds ratio (DOR) has been described as the best indicator for test performance. METHODS: To compare the performance of the standard diagnostic tests, the DOR of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), synovial fluid (SF) white blood cell (WBC) count, SF polymorphonuclear (PMN%), and leukocyte esterase (LE) were calculated...
June 10, 2017: Journal of Arthroplasty
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